2022 Ford E-350 Super Duty Drivetrains

Name: Universal Joint
Brand: Driveworks
SKU: DW-331
Price: 15.99 USD
Rating: 4.0 (28 reviews)

Below you will find various in-demand Ford Drivetrains, components and accessories for your 2022 E-350 Super Duty. Advance Auto Parts has popular E-350 Super Duty parts like Universal Joints, Transfer Cases, Differentials and more. You’ll also find aftermarket and OEM Drivetrains for other E-350 Super Duty model years including 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2021 and more. Select a category of 2022 Ford E-350 Super Duty Drivetrains below and start saving instantly.

Popular 2022 Ford E-350 Super Duty Drivetrains Categories

Differential Oil

Axle Shaft Universal Joints

Drive Shaft Support Bolts

U-Joints

Center Support Bearings

Differential Bearings

Drive Shaft Bearings

Differential Bearing Kits

Input Shaft Bearings

Axle Flange Gaskets

Spindle Lock Nuts

Essential Drivetrains for 2022 Ford E-350 Super Duties

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$15.99

Driveworks Universal Joints are designed to meet or exceed OE fit, form, and function. These universal joints are set to provide superior quality and easy installation. Driveworks Universal Joints are constructed from quality materials for extended durability. Driveworks Universal Joints are pre-lubricated with premium grease to provide a longer service life. The grease fittings are pre-installed to allow for easy maintenance (where applicable).

Product Features:

The cross is hot forged for the higher torque and horsepower
The bearing cups are made by cold forging, having higher strength and better rigidity
Bearing cups allow 360 lubricant distribution to bearing surfaces, and are precision-ground for maximum load-carrying capabilities
Lubrication grooves are designed to ensure grease penetration to entire journal and needle bearings
Grease fitting in the cross allows for easy maintenance and the flexible use of the whole assembly
Snap rings are held to strict tolerances to ensure proper cup position and retention
Nitrile rubber seals to optimize grease retention and reduce contamination

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$124.99

Are your U-joints making noise? Or has one broken? When they do break, they usually damage the axle shafts or driveshafts too. That’s a lot of unnecessary work and expense. U-joint replacement is a routine maintenance chore.

Product Features:

Front
OE Style
Direct Fit

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$19.99

Value-priced bearing meets all cataloged application requirements.

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$38.99

Center support bearings or Carrier Support Bearings are used when the driveshaft is split into two sections. It serves as a junction on the drive shaft between the transmission and the differential allowing the driveshaft to flex, relieving stress on other drive line components. Each part is engineered and designed to OE Standards. Applicable to CHEV 60-02; DODGE 64-66; FORD 75-15; GMC 60-02;. Please verify your application.

Product Features:

MAXIMUM VIBRATION DAMPENING: Rubber cushion is made of high grade rubber that ensures maximum dampening of vibration and the ability to absorb over loads.
HEAVY GAUGE STEEL FRAME: The housing frame is made from heavy gauge steel with durability that extends the service life.
READY TO INSTALL: Most center supports include a sealed bearing and dust shield and are ready to install.
For Years: 1960-2015
Weight approx: 3 Lbs
BEARING ID / BORE: 1.5750 INCH / 40 MM
CENTERLINE: 2.28 INCH / 58 MM
MOUNT WIDTH: 6.62 INCH / 168 MM
NO STUDS

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$17.49

National Oil Seals & Bearings offer a full line of premium oil seals and bearings.

Product Features:

Premium bearing design matches OEM specifications
Precision manufactured using premium-grade steel for outstanding durability and performance
Crowned raceways and rollers to ensure even load distribution for maximum life
Industry leading coverage
Professional technicians know they can depend on National

from

$15.99

The cross is hot forged for the higher torque and horsepower
The bearing cups are made by cold forging, having higher strength and better rigidity
Bearing cups allow 360 lubricant distribution to bearing surfaces, and are precision-ground for maximum load-carrying capabilities
Lubrication grooves are designed to ensure grease penetration to entire journal and needle bearings
Grease fitting in the cross allows for easy maintenance and the flexible use of the whole assembly
Snap rings are held to strict tolerances to ensure proper cup position and retention
Nitrile rubber seals to optimize grease retention and reduce contamination

from

$49.99

When you see the Spicer name, you know you are buying the highest quality product available. Spicer universal joints are no exception. Dana manufactures a full line of Spicer universal joints that are engineered to ensure longer life for vehicles in a wide variety of applications, from light vehicle to commercial and off-highway.

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$10.29

Formulated to meet the specific requirements of Subaru vehicles equipped with conventional (non-CVT) transmissions up to model year 2005. Recommended for service-fill in all Subaru automatic transmissions where SUBARU ATF HP is specified. Fuel economy demands and more sophisticated electronic controls have made automatic transmissions not only more complex, but also unique to each vehicle manufacturer. Long gone are the days of having just a couple choices of automatic transmission fluid type. Idemitsu is the factory fill Automatic Transmission Fluid (ATF) supplier to most Asian imports. Idemitsu application-specific ATF products match the exact friction materials and performance requirements of each different vehicle model for which they are made.

Product Features:

Excellent resistance to oxidation and thermal breakdown provide long fluid life and extended protection
Precisely engineered frictional characteristics guarantee smooth shifting and outstanding anti-shudder performance
Excellent resistance to oxidation and thermal breakdown provide long fluid life and extended protection
Excellent seal compatibility and conditioning reduces risk of fluid leaks due to seal shrinkage, hardening and cracking
Advanced anti-wear technology provides maximum protection to gears and bearings
Precisely engineered frictional characteristics guarantee smooth shifting and outstanding anti-shudder performance
Provides superior cleanliness, maintaining the transmission free of sludge and varnish deposits
Excellent seal compatibility and conditioning reduces risk of fluid leaks due to seal shrinkage, hardening and cracking
Advanced anti-wear technology provides maximum protection to gears and bearings

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$14.49

Valvoline DEXRON-VI/MERCON LV ATF is a full-synthetic transmission fluid formulated with advanced additive technology to meet and exceed the requirements of the General Motors DEXRON-VI specification. It is officially licensed and approved by GM and is fully back-serviceable and can be used wherever DEXRON-II and/or DEXRON-III are recommended. Recommended for use in the following applications: DEXRON-VI, DEXRON-III, DEXRON-II, and Allison C-4.

Product Features:

Formulated with full-synthetic base stocks and advanced additive technology to meet the challenging demands of automatic transmissions
Enhanced anti-shudder protection for smooth shifting and maximum power transfer
Developed with anti-wear technology to help improve transmission durability
Engineered with a proprietary blend of base oils and advanced additives to provide better oil flow at low temperatures and greater film protection at higher temperatures

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$137.99

Redline Synthetic “Shock Proof” Oil. 4 Quarts.

Product Features:

Includes four quarts of Redline Shockproof oil

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$9.99

National Oil Seals & Bearings offer a full line of premium oil seals and bearings.

Product Features:

Premium bearing design matches OEM specifications
Precision manufactured using premium-grade steel for outstanding durability and performance
Crowned raceways and rollers to ensure even load distribution for maximum life
Industry leading coverage
Professional technicians know they can depend on National

from

$27.99

Ensure a leak-free repair when servicing axle bearings or parking brake shoes. This axle shaft flange seal is a direct replacement for the original gasket and should be replaced every time work is performed at the axle flange.

Product Features:

Product Features:

Ideal replacement – this axle shaft flange seal directly replaces the original gasket without having to visit the dealer
Required for routine service – this gasket should be replaced every time work is performed at the axle flange
Durable construction – this axle shaft flange gasket is made of tough, durable materials for leak-free performance
Quality tested – this flange gasket has been designed and tested for a guaranteed fit

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$539.99

Yukon Bearing installation kits are perfect for shops & builders who have shims on the shelf and are looking to save cost over a Master Overhaul kit. This kit uses Timken bearings and races along with all high quality small parts. kit includes carrier bearings and races, pinion bearings and races, pinion seal, crush sleeve (if applicable), oil baffles and slingers (if applicable), marking compound and brush. Yukon does extensive research for each application to make sure your kit will arrive with all the correct parts you need to install your ring & pinion set.

Product Features:

Fits Dana Spicer 70HD
Fits Dana Spicer Super 70
Included are carrier bearings and races, pinion bearings and races, pinion seal, marking compound and brush.

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$384.99

This kit uses Koyo bearings and races along with all high quality small parts. kit includes carrier bearings and races, pinion bearings and races, pinion seal, crush sleeve (if applicable), oil baffles and slingers (if applicable), marking compound and brush. USA Standard Gear does extensive research for each application to make sure your kit will arrive with all the correct parts you need to install your ring & pinion set.

Product Features:

Fits Dana Spicer 70HD
Fits Dana Spicer Super 70
Uses Koyo bearings and races
Included are carrier bearings and races, pinion bearings and races, pinion seal, pinion nut, marking compound and brush.

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$544.99

Fits 1999-2007 Ford 10.5″
Included are carrier bearings and races, pinion bearings and races, pinion seal, crush sleeve , marking compound and brush.

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$454.99

Yukon Master Overhaul kits give you all the high quality parts you need to start & finish every differential job. Yukon offers more tailor-made kits than any other manufacturer in the industry to meet your specific installation needs. This kit uses Timken bearings and races along with high quality seals and small parts. Included in this kit are carrier bearings and races, pinion bearings and races, pinion seal, complete shim kit, ring gear bolts, pinion nut, crush sleeve (if applicable), oil baffles and slingers (if applicable), Thread locking compound, marking compound with brush, and gasket. Yukon’s Master Overhaul kits are the most comprehensive and complete kits on the market. They do extensive research to ensure that every kit is specially tailored to your application.

Product Features:

Fits Dana Spicer 70U
Included are Timken bearings and races, pinion bearings and races, pinion seal, complete shim kit, ring gear bolts, pinion nut, oil baffles and slingers , thread locker, marking compound with brush, and gasket.

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$40.49

This spindle nut is designed to match the fit and function of the original part on specified vehicles. Made of quality materials, it is engineered for reliable performance.

Product Features:

Direct replacement – this spindle nut matches the fit and function of the factory part on specified years, makes and models
Ideal solution – this nut is a reliable replacement for an original part that is missing or has failed due to fatigue
Durable construction – this part is made from quality materials to ensure reliable performance and long service life
Trustworthy quality – backed by team of product experts in the United States and more than a century of automotive experience

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$10.99

Spindle nut retainer for Dana 60 & 70, 1.830″ I.D., 10 outer tabs. This replaces Spicer part number 30637.

Product Features:

Spindle nut retainer for Dana Spicer 60, 70, 70U and 70HD
1.830″ I.D.
10 outer tabs

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$40.99

Spindle nut for Dana 70, 1.940″ I.D., 6 slots. This replaces Spicer part number 33732.

Product Features:

Spindle nut for Dana Spicer 70, 70U and 70HD
1.940″ I.D.
6 slots

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$26.99

Spindle nut for Dana 60 & 70, 1.940″ I.D., with plastic ring. This replaces Spicer part number 39695.

Product Features:

Spindle nut
Fits Dana Spicer 60 and 70
1.940″ I.D.
Has plastic inner ring

from

$22.49

This drive shaft bolt is designed to match the fit and function of the original part on specified vehicles. Made of quality materials, it is engineered for reliable performance.

Product Features:

Direct replacement – this engine mount bolt matches the fit and function of the factory part on specified years, makes and models
Ideal solution – this drive shaft bolt is a reliable replacement for an original part that is missing or has failed due to fatigue
Durable construction – this part is made from quality materials to ensure reliable performance and long service life
Trustworthy quality – backed by team of product experts in the United States and more than a century of automotive experience

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$18.49

Value-priced bearing meets all cataloged application requirements.

Product Features:

Brand may vary by location

from

$10.99

Manufactured with premium-grade steel, National taper bearing cups feature crowned raceways to ensure even load distribution.

Product Features:

PREMIUM MATERIALS – Precision manufactured using premium-grade steel for outstanding durability and performance
SMOOTH ROTATION – Crowned raceways for even load distribution
OE-STYLE DESIGN – Engineered to meet OE specifications
COMPREHENSIVE COVERAGE – Industry-leading coverage for domestic and import applications
RIGOROUS TESTING – Comprehensive testing throughout design and development processes by National engineers for quality you can count on

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$7.79

Manufactured with premium-grade steel, National taper bearing cups feature crowned raceways to ensure even load distribution.

Product Features:

PREMIUM MATERIALS – Precision manufactured using premium-grade steel for outstanding durability and performance
SMOOTH ROTATION – Crowned raceways for even load distribution
OE-STYLE DESIGN – Engineered to meet OE specifications
COMPREHENSIVE COVERAGE – Industry-leading coverage for domestic and import applications
RIGOROUS TESTING – Comprehensive testing throughout design and development processes by National engineers for quality you can count on

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$11.99

Value-priced bearing meets all cataloged application requirements.

Product Features:

Brand may vary by location

from

$9.99

Product Features:

Cross pin bolt for Dana Spicer 60 with c-clip axles

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$66.99

Product Features:

CONSISTENT PERFORMANCE: Matched cup and cone components ensure consistent performance
PREMIUM MATERIALS: Precision manufactured using premium-grade steel for outstanding durability and performance
SMOOTH ROTATION: Crowned raceways and rollers for even load distribution
OE-STYLE DESIGN: Engineered to meet OE specifications
COMPREHENSIVE COVERAGE: Industry-leading coverage for domestic and import applications
RIGOROUS TESTING: Comprehensive testing throughout design and development processes by National engineers for quality you can count on

Upgrade your 2022 Ford E-350 Super Duty with Top-Quality Drivetrains

When it comes to maintaining or upgrading your 2022 Ford E-350 Super Duty, nothing is more important than using high-quality OEM or aftermarket parts that you can trust. Whether you’re repairing damage to your Ford or enhancing its overall performance, Drivetrains are key to keeping your E-350 Super Duty functioning at its best. At Advance Auto Parts, we offer a wide selection of 24 Drivetrains for the 2022 Ford E-350 Super Duty, designed to meet your needs without breaking the bank. From Universal Joint replacements to Transfer Cases upgrades, we’ve got you covered with parts that fit your vehicle perfectly and ensure long-lasting performance.

Affordable Prices and Wide Selection

Shopping for Drivetrains for any vehicle can be a hassle, especially if you’re on a budget. But with Advance Auto Parts, you can find high-quality Drivetrains for your 2022 Ford E-350 Super Duty at great prices. Our Drivetrains inventory for this model ranges from just $3.49 to $556.99, with an average price of $55.13. Our 24 Drivetrains in stock come from 8 trusted brands, so you’re sure to find the right part for your 2022 Ford E-350 Super Duty without overspending.

Top Brands and High Customer Satisfaction

Advance Auto Parts takes pride in offering only the best brands in the automotive industry. For your 2022 Ford E-350 Super Duty, we stock popular OEM and aftermarket Drivetrains from top names like Spicer, Moog, Dorman, and more. Spicer Drivetrains start at just $45.99 and boast an impressive 4.6 stars average rating from customers. Moog and Dorman also bring quality to the table, with Drivetrains available starting at $3.49, and at an average 4.5 stars rating. With 582 customer reviews and counting, our 2022 Ford E-350 Super Duty Drivetrains have a strong track record of reliability, ensuring you can trust your purchase.

Explore Related Parts and More

While you’re here, don’t forget to check out other essential categories that go hand in hand with Drivetrain upgrades. Explore related part types like Batteries and Chargers, Oil and Lubricants and more to make sure your 2022 Ford E-350 Super Duty is always ready to roll. We’re committed to providing you with everything you need to keep your E-350 Super Duty in top shape, all in one place. Start shopping confidently below for your 2022 Ford E-350 Super Duty!

Best-Selling Universal Joints for 2022 Ford E-350 Super Duties

Enhance the driving experience in your Ford with 9 quality Universal Joint components, starting at $15.99.

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$54.99

You expect a lot from your vehicle, and Spicer Life Series (SPL) universal joints deliver. SPL universal joints consistently outperform competitors, so you can hit the road or trail with confidence. Check out the difference that SPL universal joints can make in your vehicle, and make sure you are getting the longer life, increased bearing capacity and lower maintenance costs that Spicer Life Series (SPL) can provide.

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$59.99

Product Features:

BUILT TO LAST – Rugged design specifically engineered for applications with higher torque and horsepower
COMPREHENSIVE COVERAGE – Available for foreign and domestic nameplates
CORROSION PROTECTION – Exclusive MICRO SHIELD coating protects against rust and corrosion
GREASABLE DESIGN – Bearing cups feature a radial design to allow 360 Degrees lubricant distribution to all bearing surfaces
KEEPS DIRT OUT – Abrasion-resistant nitrile seals provide ideal grease retention and protection from under-vehicle contaminants
RIGOROUS TESTING – Comprehensive testing throughout design and development processes by MOOG engineers for quality you can count on
STRONG AND DURABLE – Bearing cups are cold-forged, case-hardened and precision ground while steel cross is forged and carburized heat treated for strength and durability

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$46.99

Product Features:

COMPREHENSIVE COVERAGE – Available for foreign and domestic nameplates
GREASABLE DESIGN – Greasable u-joints allow for new grease to flush out contaminants and moisture
KEEPS DIRT OUT – Nitrile rubber grease seals use a compressed double lip design for effective protection against contaminants
RIGOROUS TESTING – Comprehensive testing throughout design and development processes by MOOG engineers for quality you can count on
STRONG AND DURABLE – Bearing cups are cold-forged, case-hardened and precision ground while steel cross is forged and carburized heat treated for strength and durability
Cross forging shape and flash provide easier installation and high strength

from

$37.99

Product Features:

BUILT TO LAST – Rugged design specifically engineered for applications with higher torque and horsepower
COMPREHENSIVE COVERAGE – Available for foreign and domestic nameplates
CORROSION PROTECTION – Exclusive MICRO SHIELD coating protects against rust and corrosion
GREASABLE DESIGN – Bearing cups feature a radial design to allow 360 Degrees lubricant distribution to all bearing surfaces
KEEPS DIRT OUT – Abrasion-resistant nitrile seals provide ideal grease retention and protection from under-vehicle contaminants
RIGOROUS TESTING – Comprehensive testing throughout design and development processes by MOOG engineers for quality you can count on
STRONG AND DURABLE – Bearing cups are cold-forged, case-hardened and precision ground while steel cross is forged and carburized heat treated for strength and durability

from

$15.99

The cross is hot forged for the higher torque and horsepower
The bearing cups are made by cold forging, having higher strength and better rigidity
Bearing cups allow 360 lubricant distribution to bearing surfaces, and are precision-ground for maximum load-carrying capabilities
Lubrication grooves are designed to ensure grease penetration to entire journal and needle bearings
Grease fitting in the cross allows for easy maintenance and the flexible use of the whole assembly
Snap rings are held to strict tolerances to ensure proper cup position and retention
Nitrile rubber seals to optimize grease retention and reduce contamination

from

$37.99

Product Features:

BUILT TO LAST – Rugged design specifically engineered for applications with higher torque and horsepower
COMPREHENSIVE COVERAGE – Available for foreign and domestic nameplates
CORROSION PROTECTION – Exclusive MICRO SHIELD coating protects against rust and corrosion
KEEPS DIRT OUT – Abrasion-resistant nitrile seals provide ideal grease retention and protection from under-vehicle contaminants
RIGOROUS TESTING – Comprehensive testing throughout design and development processes by MOOG engineers for quality you can count on
STRONG AND DURABLE – Bearing cups are cold-forged, case-hardened and precision ground while steel cross is forged and carburized heat treated for strength and durability

from

$41.99

Product Features:

BUILT TO LAST – Rugged design specifically engineered for fleets, off-highway and commercial vehicles
STRONG AND DURABLE – Bearing cups are cold-formed, case-hardened and precision ground for strength and durability
KEEPS DIRT OUT – Abrasion-resistant nitrile seals provide ideal grease retention and protection from under-vehicle contaminants
GREASEABLE DESIGN – Drilled and tapped grease fitting holes for easy servicing and cross trunnions with large grease reservoirs with radial grease channels for grease distribution
INHIBITS PREMATURE WEAR – Cross trunnions ground to a 15-25 RMS finish for a smooth surface free of microscopic grooves that can cause premature wear
RELIABLE PERFORMANCE – Internal anti-drainback valve integrated into thrust washer controls lubrication flow and prevents dry startup
RIGOROUS TESTING – Comprehensive testing throughout design and development processes by MOOG engineers for quality you can count on

from

$46.99

The cross is hot forged for the higher torque and horsepower
The bearing cups are made by cold forging, having higher strength and better rigidity
Bearing cups allow 360 lubricant distribution to bearing surfaces, and are precision-ground for maximum load-carrying capabilities
Lubrication grooves are designed to ensure grease penetration to entire journal and needle bearings
Grease fitting in the cross allows for easy maintenance and the flexible use of the whole assembly
Snap rings are held to strict tolerances to ensure proper cup position and retention
Nitrile rubber seals to optimize grease retention and reduce contamination

from

$55.99

Top Picks for 2022 Ford E-350 Super Duty Differentials

Upgrade Ford E-350 Super Duties with top-quality Differentials parts, including 5 OEM and aftermarket selections for your 2022 model.

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from

$14.49

Formulated with full-synthetic base stocks and advanced additive technology to meet the challenging demands of automatic transmissions
Enhanced anti-shudder protection for smooth shifting and maximum power transfer
Developed with anti-wear technology to help improve transmission durability
Engineered with a proprietary blend of base oils and advanced additives to provide better oil flow at low temperatures and greater film protection at higher temperatures

from

$69.99

Valvoline SAE 75W-140 Full Synthetic Gear Oil provides the ultimate gear protection in hypoid rear differentials and non-synchronized manual transmissions. Engineered to outperform, our formulation provides exceptional high and low temperature protection and excellent thermal stability, especially in demanding driving situations such as towing and off-roading. It contains an extreme pressure additive for better load carrying capacity and wear resistance, a limited slip additive for optimal clutch pack performance, and an anti-foaming agent for better lubrication and service life. It’s recommended for conventional rear axles and transmissions requiring EP gear lubes under high speed, high load, high torque and high horsepower conditions.

Product Features:

EXCEPTIONAL HIGH AND LOW TEMPERATURE PROTECTION ranging from -22F to 390F degrees
REDUCES CHATTERING AND PROTECTS GEAR TEETH from oxidation, rust, and wear
FIGHTS CORROSION AND RUST with emulsifying agents and safeguards against impurities, oxidation and thermal breakdown
MEETS THE DEMANDS OF CONVENTIONAL AND LIMITED SLIP REAR DIFFERENTIALS where API GL-5 is specified, as well as non-synchronized manual transmissions that require API GL-4
MEETS OR EXCEEDS PERFORMANCE REQUIREMENTS for Ford M2C-192A, GM 12346140, Chrysler MS-8985 and API GL-5

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$11.99

Value-priced bearing meets all cataloged application requirements.

Product Features:

Brand may vary by location

from

$18.99

We’ve squeezed innovation into every ounce of Valvoline FlexFill SAE 75W-90 Full Synthetic Gear Oil, the ultimate gear protection in hypoid rear differentials and non-synchronized manual transmissions. Our unique new flexible pouch makes getting into the tightest places to lubricate gears easier than ever and with less waste. The superior detergent package-based formulation contains fully synthetic basestocks and special additives that help protect parts from rust and corrosion while providing exceptional high and low temperature protection and excellent thermal stability, especially in demanding driving situations such as towing and off-roading. It contains an extreme pressure additive for better load carrying capacity, wear resistance additives that assist in protecting gear teeth, a limited slip additive for optimal clutch pack performance, and an anti-foaming agent for better lubrication and service life. Valvoline FlexFill SAE 75W-90 Full Synthetic Gear Oil is recommended for use in axle applications requiring factory-fill or drain-and-fill levels for limited slip performance.

Product Features:

FLEXIBLE POUCH FOR EASIER USE WITH LESS WASTE in tight, hard to reach undercarriage situations.
EXCEPTIONAL HIGH AND LOW TEMPERATURE PROTECTION ranging from -30F to 300F degrees for dependable coverage year-round
REDUCES CHATTERING AND PROTECTS GEAR TEETH from oxidation, rust, and wear
MEETS THE DEMANDS OF CONVENTIONAL AND LIMITED SLIP REAR DIFFERENTIALS where API GL-5 is specified, as well as non-synchronized manual transmissions that require API GL-4 or MT-1 fluid
MEETS OR EXCEEDS PERFORMANCE REQUIREMENTS for Mack GO-H and GO-J; API GL-5 and API MT-1; MIL-PRF-2105E; and SAE J2360

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$556.99

Product Features:

Each LuK GearBOX contains all the OE quality bearings needed for a professional transmission repair
LuK Differential Bearing Kits are designed to meet or exceed OEM requirements. This will ensure customer satisfaction.
LuK Differential Bearing Kits contain the bearings and seals needed to complete the job.
LuK Differential Bearing Kits include wear parts such as seals, O-rings, shaft sealing rings, support bearings and spare parts where necessary for eliminating the specific cause of failure.

In-Demand Drive Shafts and Axles for 2022 Ford E-350 Super Duties

Select from 5 premium Drive Shafts and Axles parts for your 2022 Ford E-350 Super Duty, with prices ranging from $9.99 to $45.99.

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$45.99

OE engineering and field tested experience is why the Spicer brand is the most trusted in the industry.
Forged with high-quality steel, these u-joints are heat treated and case-hardened with precision to specific levels, ensuring optimal strength and durability.
The process of precision grinding the seal and bearing surfaces helps to improve the life of the seal and bearing.
Zerk allows for lubricating at regular intervals to help extend the life of the part.

from

$22.49

Direct replacement – this engine mount bolt matches the fit and function of the factory part on specified years, makes and models
Ideal solution – this drive shaft bolt is a reliable replacement for an original part that is missing or has failed due to fatigue
Durable construction – this part is made from quality materials to ensure reliable performance and long service life
Trustworthy quality – backed by team of product experts in the United States and more than a century of automotive experience

from

$9.99

National Oil Seals & Bearings offer a full line of premium oil seals and bearings.

Product Features:

Premium bearing design matches OEM specifications
Precision manufactured using premium-grade steel for outstanding durability and performance
Crowned raceways and rollers to ensure even load distribution for maximum life
Industry leading coverage
Professional technicians know they can depend on National

from

$38.99

MAXIMUM VIBRATION DAMPENING: Rubber cushion is made of high grade rubber that ensures maximum dampening of vibration and the ability to absorb over loads.
HEAVY GAUGE STEEL FRAME: The housing frame is made from heavy gauge steel with durability that extends the service life.
READY TO INSTALL: Most center supports include a sealed bearing and dust shield and are ready to install.
For Years: 1960-2015
Weight approx: 3 Lbs
BEARING ID / BORE: 1.5750 INCH / 40 MM
CENTERLINE: 2.28 INCH / 58 MM
MOUNT WIDTH: 6.62 INCH / 168 MM
NO STUDS

from

$27.99

Product Features:

Ideal replacement – this axle shaft flange seal directly replaces the original gasket without having to visit the dealer
Required for routine service – this gasket should be replaced every time work is performed at the axle flange
Durable construction – this axle shaft flange gasket is made of tough, durable materials for leak-free performance
Quality tested – this flange gasket has been designed and tested for a guaranteed fit

Most Sold 2022 Ford E-350 Super Duty Spindles

Explore our best-selling Ford parts for the 2022 E-350 Super Duty among 4 OEM and aftermarket options starting from $3.49.

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from

$3.49

This spindle nut is designed to match the fit and function of the original part on specified vehicles. Made of quality materials, it is engineered for reliable performance.

Product Features:

Direct replacement – this spindle nut matches the fit and function of the factory part on specified years, makes and models
Ideal solution – this nut is a reliable replacement for an original part that is missing or has failed due to fatigue
Durable construction – this part is made from quality materials to ensure reliable performance and long service life
Trustworthy quality – backed by team of product experts in the United States and more than a century of automotive experience

from

$4.79

This spindle nut is designed to match the fit and function of the original part on specified vehicles. Made of quality materials, it is engineered for reliable performance.

Product Features:

Direct replacement – this spindle nut matches the fit and function of the factory part on specified years, makes and models
Ideal solution – this nut is a reliable replacement for an original part that is missing or has failed due to fatigue
Durable construction – this part is made from quality materials to ensure reliable performance and long service life
Trustworthy quality – backed by team of product experts in the United States and more than a century of automotive experience

from

$40.49

This spindle nut is designed to match the fit and function of the original part on specified vehicles. Made of quality materials, it is engineered for reliable performance.

Product Features:

Direct replacement – this spindle nut matches the fit and function of the factory part on specified years, makes and models
Ideal solution – this nut is a reliable replacement for an original part that is missing or has failed due to fatigue
Durable construction – this part is made from quality materials to ensure reliable performance and long service life
Trustworthy quality – backed by team of product experts in the United States and more than a century of automotive experience

from

$39.99

This spindle nut is designed to match the fit and function of the original part on specified vehicles. Made of quality materials, it is engineered for reliable performance.

Product Features:

Direct replacement – this spindle nut matches the fit and function of the factory part on specified years, makes and models
Ideal solution – this nut is a reliable replacement for an original part that is missing or has failed due to fatigue
Durable construction – this part is made from quality materials to ensure reliable performance and long service life
Trustworthy quality – backed by team of product experts in the United States and more than a century of automotive experience

Top-Rated Drivetrains Brands For Your 2022 Ford E-350 Super Duty

Shop for the best-rated brands offering Drivetrains and other products for your 2022 Ford E-350 Super Duties. Below you’ll find some of our best rated Drivetrains from Spicer, Moog, and Dorman, and more. Drivetrains from these brands that fit a 2022 E-350 Super Duty start at just $3.49 and are rated as high as 4.6 stars. OEM and aftermarket Drivetrains don’t get more top quality, durable, and affordable than from the brands below.

Popular Spicer 2022 Ford E-350 Super Duty Drivetrains

When it comes to maintaining or upgrading your 2022 Ford E-350 Super Duty, using quality Drivetrains is essential to ensure durability and a perfect fit. Spicer ticks all of those boxes. We offer a wide selection of Spicer Drivetrains, specifically designed for the 2022 Ford E-350 Super Duty. With over 2 Spicer brand Drivetrains in stock, you’re sure to find what you need. The prices for these top-notch parts start as low as $45.99, with an average price of just $50.49. Plus, with over 11 customer reviews and an average rating of 4.6 stars, you can trust that our Spicer Drivetrains will get the job done right. Choose Advance Auto Parts for reliability, quality, and expert-approved parts that keep your vehicle running strong.

from $45.99

(10)

Universal Joint, Greaseable 1410 Series

“Went in perfect”

from $54.99

(1)

Universal Joint

“Spicer U joints are great. These are actual OE parts on my truck.”

Popular Moog 2022 Ford E-350 Super Duty Drivetrains

Moog auto parts is one of the highest quality Drivetrain brands in the market. Any 2022 Ford E-350 Super Duty owner should feel confident when installing genuine Moog parts in their vehicle. To ensure the best fit and performance for your 2022 E-350 Super Duty, Advance Auto Parts carries a full inventory of 3 Moog Drivetrains. Plus you will be keeping your Ford in peak condition while saving money because prices on these Moog Drivetrains range from $37.99 to $59.99, plus, with more than 100 customer reviews and an impressive 4.5 stars average rating, you can be confident the Fram Drivetrains below will deliver on both quality and value.

from $59.99

(39)

Greaseable Super Strength Universal Joint

“quality product”

from $46.99

(20)

Greaseable Premium Universal Joint

“Great!”

from $37.99

(41)

Greaseable Super Strength Universal Joint

“Easy install and great way to have sting durability with access to grease points”

FAQs for 2022 Ford E-350 Super Duty Drivetrains

Which Drivetrains are best-sellers for 2022 Ford E-350 Super Duties?

Out of 24 Drivetrains that fit 2022 Ford E-350 Super Duties, the following parts are the top sellers:

Flex Fill Transmission & Differential Gear Oil: Full Synthetic 75W-90, 1 Quart (12507273) – $18.99
Greaseable Super Strength Universal Joint (10086981) – $59.99
Greaseable Super Strength Universal Joint (10086947) – $37.99

What’s the price range for 2022 Ford E-350 Super Duty Drivetrains?

Drivetrain prices for the 2022 Ford E-350 Super Duty start at $3.49 and go up to $556.99 for the most premium parts.

What’s the average price of a Drivetrain for a 2022 Ford E-350 Super Duty?

The average price for Drivetrains for the 2022 Ford E-350 Super Duty is $55.13. Keep in mind the variety of part types within our Drivetrain category so you are likely to find a wide range of prices across a variety of parts and components.

Does Advance Auto Parts sell Drivetrains for other Ford E-350 Super Duty model years?

Yes, we currently carry Drivetrains for 23 model years of Ford E-350 Super Duties between 2000 and 2025. Drivetrains are bought most frequently for the following model years: 2021, 2019, 2018, 2017, 2016, 2015, 2014, 2013, and 2012.

What are the cheapest Drivetrains for my 2022 Ford E-350 Super Duty?

The cheapest 2022 Ford E-350 Super Duty Drivetrains we carry in stock are:

Standard Spindle Nut 3/4 In.-16 Hex Size 1-1/16 In. (21260547) – $3.49
Standard Spindle Nut 3/4 In.-16 Hex Size 1-1/16 In. (sold by each) (22149122) – $4.79
Bearings (3272400) – $9.99
Taper Bearing Cone (5050049) – $11.99
DEXRON – VI ATF Full Synthetic Automatic Transmission Fluid, 1 Quart (12079201) – $14.49

What are the top-rated Drivetrains that fit the 2022 Ford E-350 Super Duty?

Out of 582 reviews by customers, our 2022 Ford E-350 Super Duty Drivetrains have an average customer rating of . These are some of the highest-rated Drivetrain types for the 2022 Ford E-350 Super Duty and their top-rated products:

Universal Joints
- Universal Joint (10855000) – $54.99
- Greaseable Super Strength Universal Joint (10086981) – $59.99
- Greaseable Premium Universal Joint (10086907) – $46.99
Differentials
- Universal Joint (10855000) – $54.99
- Greaseable Super Strength Universal Joint (10086981) – $59.99
- Greaseable Premium Universal Joint (10086907) – $46.99
Spindles
- Universal Joint (10855000) – $54.99
- Greaseable Super Strength Universal Joint (10086981) – $59.99
- Greaseable Premium Universal Joint (10086907) – $46.99

What types of Drivetrains do you sell for my 2022 Ford E-350 Super Duty?

As of 11/2/25, these are some of the most in-demand types of Drivetrains for a 2022 Ford E-350 Super Duty:

Can I get help with 2022 Ford E-350 Super Duty Drivetrain orders?

Contact our customer support team, by chat or phone, through the help desk page, where you can find instant answers about Ford Drivetrains and more.

What is your return policy for Ford E-350 Super Duty Drivetrains?

Advance Auto Parts keeps returns simple. For new Ford E-350 Super Duty Drivetrains and accessories, your online orders can be returned, in their original condition, within 45 days. For requirements, see the returns page.

2022 Ford E-350 Super Duty Drivetrains

Driveworks – Universal Joint (Part No.DW-331)

Omix – U-Joint; 1480 Series (Part No.5-806X)

Driveworks – Ball Bearing (Part No.S-HB-88107-A)

Anchor – Center Support Bearing Motor Mount: Center, 1 Piece (Part No.6053)

National – Bearings (Part No.15101)

Driveworks – Universal Joint (Part No.DW-331BL)

Spicer – Universal Joint (Part No.5-1350-1X)

Idemitsu – Type HP Automatic Transmission Fluid , 1 Quart (Part No.10107-042F)

Valvoline – DEXRON – VI ATF Full Synthetic Automatic Transmission Fluid, 1 Quart (Part No.822405)

Yukon Gear – Redline Synthetic "Shock Proof" Oil – 4 Quarts (Part No.15004)

National – Bearings (Part No.15245)

Dorman – Axle Flange Gasket Kit (Part No.926-880)

Yukon Gear – Bearing Install Kit For Dana 70-HD & Super-70 Differential (Part No.11033)

USA Standard Gear – Bearing Kit For Dana 70HD & Super-70 (Part No.58002)

Yukon Gear – Bearing Install Kit For ’99-’07 Ford 10.5" Differential (Part No.11038)

Yukon Gear – Master Overhaul Kit For Dana 70-U Differential (Part No.14040)

Dorman – Spindle Nut 2 In.-16 Hex Size 3 In. (sold by each) (Part No.615-133)

Yukon Gear – Spindle Nut Retainer For Dana 60 & 70, 1.830" I.D., 10 Outer TABS (Part No.33477)

Yukon Gear – Spindle Nut For Dana 70, 1.940" I.D., 6 Slots (Part No.33479)

Yukon Gear – Spindle Nut For Dana 60 & 70, 1.940" I.D., With Plastic Ring (Part No.33486)

Dorman – Help – Driveshaft Flange Bolts (Part No.80992)

Driveworks – Tapered Cone Wheel Bearing Assembly (Part No.S-387-AS)

National – Bearing Race (Part No.382A)

National – Bearing Race (Part No.LM102910)

Driveworks – Taper Bearing Cone (Part No.S-LM-104949)

Yukon Gear – 9.25" Chrysler, Dana 60 Semi-Float X/P Bolt, 80 & Up, 5/16" Head, Tapered Shoulder (Part No.33238)

National – Multi-Purpose Bearing (Part No.A-50)

Spicer – Universal Joint (Part No.5-1410X)

MOOG Driveline Products – Greaseable Super Strength Universal Joint (Part No.295)

MOOG Driveline Products – Greaseable Premium Universal Joint (Part No.330)

MOOG Driveline Products – Greaseable Super Strength Universal Joint (Part No.232)

Driveworks – Universal Joint (Part No.DW-331)

MOOG Driveline Products – Non-Greaseable Super Strength Universal Joint (Part No.231)

MOOG Driveline Products – Greaseable Premium Universal Joint (Part No.331)

Driveworks – Universal Joint (Part No.DW-330)

Spicer – Universal Joint (Part No.5-1410-1X)

National – Bearings (Part No.15101)

Valvoline – DEXRON – VI ATF Full Synthetic Automatic Transmission Fluid, 1 Quart (Part No.822405)

Valvoline – SynPower Transmission & Differential Gear Oil: Full Synthetic 75W-140, 1 Gallon (Part No.887344)

Driveworks – Taper Bearing Cone (Part No.S-LM-104949)

Valvoline – Flex Fill Transmission & Differential Gear Oil: Full Synthetic 75W-90, 1 Quart (Part No.889785)

LuK – Differential Repair Kit (Part No.GDK332-HD)

Spicer – Universal Joint, Greaseable 1410 Series (Part No.5-160X)

Dorman – Help – Driveshaft Flange Bolts (Part No.80992)

National – Bearings (Part No.15245)

Anchor – Center Support Bearing Motor Mount: Center, 1 Piece (Part No.6053)

Dorman – Axle Flange Gasket Kit (Part No.926-880)

Dorman – Standard Spindle Nut 3/4 In.-16 Hex Size 1-1/16 In. (Part No.615-072.1)

Dorman – Standard Spindle Nut 3/4 In.-16 Hex Size 1-1/16 In. (sold by each) (Part No.615-072)

Dorman – Spindle Nut 2 In.-16 Hex Size 3 In. (sold by each) (Part No.615-133)

Dorman – Spindle Nut 2 In.-16 Hex Size 3 In. (Part No.615-133.1)