2022 Mercedes-Benz E350 Engine Cooling Parts

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Keep Your 2022 Mercedes-Benz E350 in Top Shape with Quality Engine Cooling Parts

Whether you’re repairing or upgrading your Engine Cooling Part, using high-quality parts is key to keeping your 2022 Mercedes-Benz E350 looking sharp and performing at its best. At Advance Auto Parts we carry a wide selection of dependable options, including Coolant Reservoir Caps, Thermostat and Water Outlet Assemblies, and Coolant Reservoirs. Whether you’re replacing a damaged part or enhancing your truck’s style and protection, you’ll find exactly what you need to get the job done right.

Top-Rated Engine Cooling Parts from Trusted Brands

Looking for a reliable Engine Cooling Part? We’ve got you covered with options from brands you know and trust like Carquest Premium. For example, Carquest Premium Engine Cooling Parts start at just $19.99 with an average 4.5 star rating. With over 2 reviews and a solid 5.0 star average, you can shop with confidence knowing other Mercedes-Benz E350 owners approve.

Competitive Prices and Extensive Inventory

The average price for a 2022 Mercedes-Benz E350 Engine Cooling Part at Advance Auto Parts is around $90.62, with a range that starts at $17.99 and goes up to $252.99. With 8 options in stock from 3 trusted brands, finding the right fit is easy. Popular picks like Rein Cap-Expansion Tank, CPE0029P, Dorman Radiator Mount Bushings, Pack of 2, 927-245, and Carquest Engine Auxiliary Water Pump_New, T1380 start at just $17.99 and offer a great balance of form and function.

Explore Related Parts

While you’re upgrading or replacing your Engine Cooling Part, don’t forget to check out other key components like Air Conditioning Parts and Blower Motor and Related Products. At Advance Auto Parts, we’re here to help you keep your 2022 Mercedes-Benz E350 in peak condition, inside and out.

Essential 2022 Mercedes-Benz E350 Engine Cooling Parts

Dorman – Dorman Auxiliary Coolant Pump, 902-065 (Part No.902-065)

Dorman Auxiliary Coolant Pump, 902-065

from

$215.99
This engine auxiliary water pump is designed to match the fit and function of the original pump on specified applications, and is engineered for reliable performance and durability.
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Carquest Premium – Carquest Engine Auxiliary Water Pump_New, T1380 (Part No.T1380)

Carquest Engine Auxiliary Water Pump_New, T1380

from

$252.99
This new pump is 100% tested to ensure the highest quality. Each unit is built to meet or exceed all OE specifications and is validated for fit, form, and function. Application specific design to ensure a perfect fit and correct operation for unsurpassed quality.
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Carquest Premium – Carquest Engine Auxiliary Water Pump_New, T1395 (Part No.T1395)

Carquest Engine Auxiliary Water Pump_New, T1395

from

$456.99
This new pump is 100% tested to ensure the highest quality. Each unit is built to meet or exceed all OE specifications and is validated for fit, form, and function. Application specific design to ensure a perfect fit and correct operation for unsurpassed quality.
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Motorad – Motorad Integrated Thermostat Housing: With Seal, 189 Degrees, 623-189 (Part No.623-189)

Motorad Integrated Thermostat Housing: With Seal, 189 Degrees, 623-189

from

$61.99
Manufactured with OEM quality materials and safety standards by an OE Supplier. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant. Offset design, air relief valve, and OEM style seals included where applicable
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Carquest Premium – Carquest Integrated Thermostat Housing: With Sensor, With Gasket, 212 Degrees, 49382 (Part No.49382)

Carquest Integrated Thermostat Housing: With Sensor, With Gasket, 212 Degrees, 49382

from

$242.99
Carquest Premium Integrated Housing Thermostats are manufactured with OEM quality materials and safety standards by an OE Supplier. This integrated thermostat housing will meet and exceed the expectations of the OE thermostat to insure the best product for your cooling system. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant as well as the design and function of the housing. Offset design, air relief valve, and OEM style seals included where applicable.
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Motorad – Motorad Integrated Thermostat Housing: With Sensor, Spring Clip, Seal, 212 Degrees, 785-212 (Part No.785-212)

Motorad Integrated Thermostat Housing: With Sensor, Spring Clip, Seal, 212 Degrees, 785-212

from

$279.99
Manufactured with OEM quality materials and safety standards by an OE Supplier. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant.
See More

Dorman – Dorman Thermostat Assembly: Includes Gasket, Housing, and Thermostat, 902-5183 (Part No.902-5183)

Dorman Thermostat Assembly: Includes Gasket, Housing, and Thermostat, 902-5183

from

$45.99
This replacement engine coolant thermostat housing is engineered to match the fit and durability of the stock thermostat housing on specified vehicles. It is designed to withstand extreme temperature changes to extend service life.
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Carquest Premium – Carquest Integrated Thermostat Housing: With Sensor, 216 Degrees, 1218-216 (Part No.1218-216)

Carquest Integrated Thermostat Housing: With Sensor, 216 Degrees, 1218-216

from

$221.99
Carquest Premium Integrated Housing Thermostats are manufactured with OEM quality materials and safety standards by an OE Supplier. This integrated thermostat housing will meet and exceed the expectations of the OE thermostat to insure the best product for your cooling system. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant as well as the design and function of the housing. Offset design, air relief valve, and OEM style seals included where applicable.
See More

URO Parts – URO Parts Radiator/Expansion Tank Cap, 2105010615 (Part No.2105010615)

URO Parts Radiator/Expansion Tank Cap, 2105010615

from

$19.99
For European vehicles, A.P.A. manufactures the URO Parts brand of quality replacement parts, which meet or exceed OEM specifications. URO Parts components are ideal for both professional and DIY vehicle repair, and are often the exclusive aftermarket alternative to overpriced €œGenuine€ components. By reducing deferred maintenance with URO Parts, you will increase the bottom line of your business. With its URO Premium line, A.P.A. offers problem-solving upgraded components that are superior to failure-prone OEM parts in design and/or materials. A.P.A. is so confident in the longevity and reliability of URO Premium products, . URO Parts also specializes in accurate reproduction parts for classic vehicles, including a huge variety of items that are no longer available from the dealer.
See More

Rein – Rein Cap-Expansion Tank, CPE0029P (Part No.CPE0029P)

Rein Cap-Expansion Tank, CPE0029P

from

$33.99
Rein Automotive OE Quality expansion tank caps are designed to be direct replacements for OE caps. Rein caps are designed to match or exceed the OE materials used and are produced to the highest standards to ensure long service life. Rein Automotive OE quality expansion tank caps keep the coolant system at the proper pressure just like the OE cap.
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Carquest Premium – Carquest Standard Reservoir Cap: 21 PSI, 10253 (Part No.10253)

Carquest Standard Reservoir Cap: 21 PSI, 10253

from

$19.99
Crafted to meet the exact specifications set by Original Equipment Manufacturers (OEM), these products are engineered for effortless installation and removal. Constructed from premium-grade components, incorporating proper relief and vacuum valves, they ensure optimal performance even in the most demanding automotive cooling systems. Rigorously quality-tested, these components provide exceptional, out-of-the-box performance and superior durability to meet or exceed the highest standards of today’s vehicles.
See More

Dorman – Dorman Radiator Mount Bushings, Pack of 2, 927-245 (Part No.927-245)

Dorman Radiator Mount Bushings, Pack of 2, 927-245

from

$17.99
This radiator mount bushing is designed to match the fit and function of the original part on specified vehicles. Made of quality materials, it is engineered for reliable performance.
See More

Rein – Rein Radiator Mount, AVM0699 (Part No.AVM0699)

Rein Radiator Mount, AVM0699

from

$23.99
Anti-vibration parts dampen vibration harmonics from the engine and drive line components to rest of the vehicle. This in turn reduces vibration and noise which can be felt and heard while the vehicle is in operation. Rein Automotive anti-vibration parts are application specific and match the design and function of the OE parts.
See More

Rein – Rein RADIATOR MOUNT, AVM0738 (Part No.AVM0738)

Rein RADIATOR MOUNT, AVM0738

from

$5.99
Anti-vibration parts dampen vibration harmonics from the engine and drive line components to rest of the vehicle. This in turn reduces vibration and noise which can be felt and heard while the vehicle is in operation. Rein Automotive anti-vibration parts are application specific and match the design and function of the OE parts.
See More

Dorman – Dorman Pressurized Coolant Reservoir: Black and White, Plastic, Original Equipment Replacement, 603-283 (Part No.603-283)

Dorman Pressurized Coolant Reservoir: Black and White, Plastic, Original Equipment Replacement, 603-283

from

$72.99
This replacement engine coolant reservoir is manufactured from quality materials to withstand the stresses of underhood heat and engine vibration. It is engineered and manufactured to match the fit and function of the original part.
See More

Rein – Rein Expansion Tank, EPT0132 (Part No.EPT0132)

Rein Expansion Tank, EPT0132

from

$64.99
Rein Automotive OE quality expansion tanks, install, fit and perform the way the original manufacturer intended. These tanks are designed to match or exceed the OE materials used and are produced from virgin plastic with no regrind to prevent cracking from heat cycles and ensure the plastic is durable and will have a long service life.
See More

Rein – Rein Expansion Tank, EPT0029 (Part No.EPT0029)

Rein Expansion Tank, EPT0029

from

$63.99
Rein Automotive OE quality expansion tanks, install, fit and perform the way the original manufacturer intended. These tanks are designed to match or exceed the OE materials used and are produced from virgin plastic with no regrind to prevent cracking from heat cycles and ensure the plastic is durable and will have a long service life.
See More

Rein – Rein Expansion Tank Kit, EPK0132 (Part No.EPK0132)

Rein Expansion Tank Kit, EPK0132

from

$88.99
Rein Automotive OE quality expansion tank kits, install, fit and perform the way the original manufacturer intended. These tanks are designed to match or exceed the OE materials used and are produced from virgin plastic with no regrind to prevent cracking from heat cycles and ensure the plastic is durable and will have a long service life
See More

URO Parts – URO Parts Expansion Tank, 2045000749 (Part No.2045000749)

URO Parts Expansion Tank, 2045000749

from

$55.99
For European vehicles, A.P.A. manufactures the URO Parts brand of quality replacement parts, which meet or exceed OEM specifications. URO Parts components are ideal for both professional and DIY vehicle repair, and are often the exclusive aftermarket alternative to overpriced €œGenuine€ components. By reducing deferred maintenance with URO Parts, you will increase the bottom line of your business. With its URO Premium line, A.P.A. offers problem-solving upgraded components that are superior to failure-prone OEM parts in design and/or materials. A.P.A. is so confident in the longevity and reliability of URO Premium products, . URO Parts also specializes in accurate reproduction parts for classic vehicles, including a huge variety of items that are no longer available from the dealer.
See More

URO Parts – URO Parts Expansion Tank w/ Sensor, 2115000049 (Part No.2115000049)

URO Parts Expansion Tank w/ Sensor, 2115000049

from

$31.49
For European vehicles, A.P.A. manufactures the URO Parts brand of quality replacement parts, which meet or exceed OEM specifications. URO Parts components are ideal for both professional and DIY vehicle repair, and are often the exclusive aftermarket alternative to overpriced €œGenuine€ components. By reducing deferred maintenance with URO Parts, you will increase the bottom line of your business. With its URO Premium line, A.P.A. offers problem-solving upgraded components that are superior to failure-prone OEM parts in design and/or materials. A.P.A. is so confident in the longevity and reliability of URO Premium products, . URO Parts also specializes in accurate reproduction parts for classic vehicles, including a huge variety of items that are no longer available from the dealer.
See More

Dorman – Dorman Pressurized Coolant Reservoir: Black and Clear, Plastic, Original Equipment Replacement, 603-257 (Part No.603-257)

Dorman Pressurized Coolant Reservoir: Black and Clear, Plastic, Original Equipment Replacement, 603-257

from

$65.99
This replacement engine coolant reservoir is manufactured from quality materials to withstand the stresses of under hood heat and engine vibration. It is engineered and manufactured to match the fit and function of the original part.
See More

Most Popular Coolant Reservoir Caps for 2022 Mercedes-Benz E350s

Enhance your 2022 Mercedes-Benz E350 with one of the 2 Coolant Reservoir Caps we have in stock, starting at just $19.99.

Carquest Premium – Carquest Standard Reservoir Cap: 21 PSI, 10253 (Part No.10253)

Carquest Standard Reservoir Cap: 21 PSI, 10253

from

$19.99
Crafted to meet the exact specifications set by Original Equipment Manufacturers (OEM), these products are engineered for effortless installation and removal. Constructed from premium-grade components, incorporating proper relief and vacuum valves, they ensure optimal performance even in the most demanding automotive cooling systems. Rigorously quality-tested, these components provide exceptional, out-of-the-box performance and superior durability to meet or exceed the highest standards of today’s vehicles.
See More

Rein – Rein Cap-Expansion Tank, CPE0029P (Part No.CPE0029P)

Rein Cap-Expansion Tank, CPE0029P

from

$33.99
Rein Automotive OE Quality expansion tank caps are designed to be direct replacements for OE caps. Rein caps are designed to match or exceed the OE materials used and are produced to the highest standards to ensure long service life. Rein Automotive OE quality expansion tank caps keep the coolant system at the proper pressure just like the OE cap.
See More

Best-Selling 2022 Mercedes-Benz E350 Thermostat and Water Outlet Assembly

Upgrade your E350 with our best-selling Thermostat and Water Outlet Assembly.

Carquest Premium – Carquest Integrated Thermostat Housing: With Sensor, 216 Degrees, 1218-216 (Part No.1218-216)

Carquest Integrated Thermostat Housing: With Sensor, 216 Degrees, 1218-216

from

$221.99
Carquest Premium Integrated Housing Thermostats are manufactured with OEM quality materials and safety standards by an OE Supplier. This integrated thermostat housing will meet and exceed the expectations of the OE thermostat to insure the best product for your cooling system. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant as well as the design and function of the housing. Offset design, air relief valve, and OEM style seals included where applicable.
See More

Top-Quality Coolant Reservoirs for 2022 Mercedes-Benz E350s

Choose a high-quality OEM or aftermarket Coolant Reservoir for Mercedes-Benz E350s and enjoy top-notch performance from $64.99.

Rein – Rein Expansion Tank Kit, EPK0132 (Part No.EPK0132)

Rein Expansion Tank Kit, EPK0132

from

$88.99
Rein Automotive OE quality expansion tank kits, install, fit and perform the way the original manufacturer intended. These tanks are designed to match or exceed the OE materials used and are produced from virgin plastic with no regrind to prevent cracking from heat cycles and ensure the plastic is durable and will have a long service life
See More

Rein – Rein Expansion Tank, EPT0132 (Part No.EPT0132)

Rein Expansion Tank, EPT0132

from

$64.99
Rein Automotive OE quality expansion tanks, install, fit and perform the way the original manufacturer intended. These tanks are designed to match or exceed the OE materials used and are produced from virgin plastic with no regrind to prevent cracking from heat cycles and ensure the plastic is durable and will have a long service life.
See More

Our Top Pick for a 2022 Mercedes-Benz E350 Engine Auxiliary Water Pump

Invest in a durable Engine Auxiliary Water Pump for your 2022 Mercedes-Benz, knowing you’re getting trusted brands and expert craftsmanship.

Carquest Premium – Carquest Engine Auxiliary Water Pump_New, T1380 (Part No.T1380)

Carquest Engine Auxiliary Water Pump_New, T1380

from

$252.99
This new pump is 100% tested to ensure the highest quality. Each unit is built to meet or exceed all OE specifications and is validated for fit, form, and function. Application specific design to ensure a perfect fit and correct operation for unsurpassed quality.
See More

Radiator Mounts for 2022 Mercedes-Benz E350s

Make a smart move for your 2022 Mercedes-Benz E350 with products all priced from $17.99 to $23.99.

Rein – Rein Radiator Mount, AVM0699 (Part No.AVM0699)

Rein Radiator Mount, AVM0699

from

$23.99
Anti-vibration parts dampen vibration harmonics from the engine and drive line components to rest of the vehicle. This in turn reduces vibration and noise which can be felt and heard while the vehicle is in operation. Rein Automotive anti-vibration parts are application specific and match the design and function of the OE parts.
See More

Dorman – Dorman Radiator Mount Bushings, Pack of 2, 927-245 (Part No.927-245)

Dorman Radiator Mount Bushings, Pack of 2, 927-245

from

$17.99
This radiator mount bushing is designed to match the fit and function of the original part on specified vehicles. Made of quality materials, it is engineered for reliable performance.
See More

Top-Rated Engine Cooling Part Brands For Your 2022 Mercedes-Benz E350

When it comes to finding the perfect Engine Cooling Part for your 2022 Mercedes-Benz E350, Advance Auto Parts has you covered with a wide selection of high-quality OEM and aftermarket options from 3 trusted brands. We carry the most popular Engine Cooling Part brands including Carquest Premium, and more, all known for their exceptional customer ratings (average brand rating of 4.5 stars) and competitive prices, as low as $19.99. Purchasing a Engine Cooling Part from us here at Advance Auto Parts is a smart move for both you and your 2022 Mercedes-Benz E350, providing peace of mind with parts that meet or exceed OEM standards.

Popular Carquest Premium 2022 Mercedes-Benz E350 Engine Cooling Parts

If you’re looking for a top-quality Engine Cooling Part for your 2022 Mercedes-Benz E350, Advance Auto Parts has exactly what you need with our selection of Carquest Premium Engine Cooling Parts. We have 1 Carquest Premium Engine Cooling Parts in stock for this fitment, all known for their durability and precision fit. With prices starting at just $19.99, you’ll find the perfect Engine Cooling Part for your needs and budget. Carquest Premium Engine Cooling Parts for the 2022 Mercedes-Benz E350 come highly rated, with over 1 customer reviews and an impressive average rating of 4.5 stars. Choosing a Carquest Premium Engine Cooling Part from Advance Auto Parts is a smart move to ensure quality and value for your vehicle.
Carquest Standard Reservoir Cap: 21 PSI, 10253
from $19.99
(1)
Carquest Standard Reservoir Cap: 21 PSI, 10253
“Works well, looks identical to OEM!”

FAQs for 2022 Mercedes-Benz E350 Engine Cooling Parts

What are the best-selling Engine Cooling Parts for 2022 Mercedes-Benz E350s?

Out of 8 Engine Cooling Parts that fit 2022 Mercedes-Benz E350s, the following parts are the top sellers:

What’s the price range for 2022 Mercedes-Benz E350 Engine Cooling Parts?

The prices of Engine Cooling Parts for the 2022 Mercedes-Benz E350 range from $17.99 up to $252.99 for the most premium parts.

What is the average price of an Engine Cooling Part for a 2022 Mercedes-Benz E350?

The average price for Engine Cooling Parts for the 2022 Mercedes-Benz E350 is $90.62. Keep in mind the variety of part types within our Engine Cooling Part category, where you are likely to find a wide range of prices across a variety of parts and components.

Does Advance Auto Parts sell Engine Cooling Parts for other Mercedes-Benz E350 model years?

Yes, we carry Engine Cooling Parts for 16 model years of Mercedes-Benz E350s between 2006 and 2026. The following model years are the most popular for Engine Cooling Part purchases: 2023, 2021, 2020, 2016, 2015, 2014, 2013, 2012, and 2011.

What are the cheapest Engine Cooling Parts for my 2022 Mercedes-Benz E350?

The cheapest 2022 Mercedes-Benz E350 Engine Cooling Parts we carry are:

Does Advance Auto Parts sell Engine Cooling Parts for any other 2022 Mercedes-Benz models?

Yes. We stock Engine Cooling Parts for 15 other popular 2022 Mercedes-Benz models. Some of the most popular are 2022 Sprinter 2500 Engine Cooling Parts, 2022 Sprinter 3500 Engine Cooling Parts, 2022 C300 Engine Cooling Parts, 2022 Metris Engine Cooling Parts, and 2022 S500 Engine Cooling Parts.

What types of Engine Cooling Parts do you sell for my 2022 Mercedes-Benz E350?

As of 8/2/26, these are some of the most in-demand types of Engine Cooling Parts for a 2022 Mercedes-Benz E350:

Can I get help with 2022 Mercedes-Benz E350 Engine Cooling Part orders?

Contact our customer support team by chat or phone, through the help desk page, where you can find instant answers about Mercedes-Benz Engine Cooling Parts and more.

What is your return policy for Mercedes-Benz E350 Engine Cooling Parts?

Advance Auto Parts keeps returns simple. For new Mercedes-Benz E350 Engine Cooling Parts and accessories, your online orders can be returned, in their original condition, within 45 days. For requirements, see the returns page.