2022 Mercedes-Benz E350 Cooling and Climate Controls
Find Your Specific 2022 Mercedes-Benz E350 Cooling and Climate Controls
Below you will find various in-demand Mercedes-Benz Cooling and Climate Controls, components and accessories for your 2022 E350. Advance Auto Parts has popular E350 parts like Heating Parts, Engine Cooling Parts, Air Conditioning Parts and more. You’ll also find aftermarket and OEM Cooling and Climate Controls for other E350 model years including
2011,
2012,
2013,
2014,
2015,
2016,
2020,
2021,
2023 and more. Select a category of 2022 Mercedes-Benz E350 Cooling and Climate Controls below and start saving instantly.
Popular 2022 Mercedes-Benz E350 Cooling and Climate Controls Categories
Essential Cooling and Climate Controls for 2022 Mercedes-Benz E350s
Carquest Premium – Heater Core (Part No.910568)
from
$76.99
Carquest Premium offers a complete line of automotive heater cores covering 94% of all North American vehicle applications. Carquest Premium provides value in several ways, including increased thermal performance and resistance to corrosion using enhanced design features, such as the latest fin and tube technology and design standardization for maximum availability. Carquest Premium offers certified heater cores that meet or exceed OE specifications and are all fitment checked in the actual vehicle’s HVAC heater module and are, thus, ready to be installed right out of the box for a “Drop-In Fit”. Carquest Premium heater cores are engineered and manufactured under ISO TS16949 quality systems and are 100% leak tested.
Product Features:
See More
Product Features:
- All heater cores are designed and tested to match or exceed OE specifications for form, fit and performance with a clear focus on obtaining the highest heat transfer performance possible through use of quality materials and manufacturing processes to ensu
- Carquest Premium heater cores are engineered and manufactured under ISO TS16949 quality systems and are 100% leak tested.
- Provides value in several ways, including increased thermal performance and resistance to corrosion using enhanced design features, such as the latest fin and tube technology and design standardization for maximum availability.
- Carquest Premium offers a complete line of automotive heater cores covering 94% of all North American vehicle applications.
- Our advanced engineering methods coupled with our innovative manufacturing technology provides products to the aftermarket that meet or exceed form, fit, and function of OEM Parts
Carquest Premium – Heater Core (Part No.910677)
from
$73.99
Carquest Premium offers a complete line of automotive heater cores covering 94% of all North American vehicle applications. Carquest Premium provides value in several ways, including increased thermal performance and resistance to corrosion using enhanced design features, such as the latest fin and tube technology and design standardization for maximum availability. Carquest Premium offers certified heater cores that meet or exceed OE specifications and are all fitment checked in the actual vehicle’s HVAC heater module and are, thus, ready to be installed right out of the box for a “Drop-In Fit”. Carquest Premium heater cores are engineered and manufactured under ISO TS16949 quality systems and are 100% leak tested.
Product Features:
See More
Product Features:
- All heater cores are designed and tested to match or exceed OE specifications for form, fit and performance with a clear focus on obtaining the highest heat transfer performance possible through use of quality materials and manufacturing processes to ensu
- Carquest Premium heater cores are engineered and manufactured under ISO TS16949 quality systems and are 100% leak tested.
- Provides value in several ways, including increased thermal performance and resistance to corrosion using enhanced design features, such as the latest fin and tube technology and design standardization for maximum availability.
- Carquest Premium offers a complete line of automotive heater cores covering 94% of all North American vehicle applications.
- Our advanced engineering methods coupled with our innovative manufacturing technology provides products to the aftermarket that meet or exceed form, fit, and function of OEM Parts
Carquest Premium – Radiator: With Transmission Oil Cooler (Part No.812868)
from
$249.99
Carquest Premium radiators are designed and engineered for maximum performance, using the highest-grade materials to ensure all radiators meet or exceed original equipment (O.E.) fit, form and function. Carquest Premium radiators are built by manufacturers that meet IATF 16949 certified framework, an internationally recognized proof of quality in the automotive industry. Most modern vehicles use radiators with plastic tanks and our parts are engineered with integrated ribbing to prevent damage during thermal cycling. Carquest Premium radiators are also 100% tested to ensure a durable, leak-free cooling system repair.
Product Features:
See More
Product Features:
- Thermal tested under real-life temperature simulations
- High tensile strength aluminum for maximum crimp strength
- Plastic tanks are engineeredáwith integrated ribbingáfor addedástrength to withstand cracks, bowing and distortion during thermal cycles
- Thermal expansion slots extend core life and reduce failure rates by allowing improved core expansion and contraction during systematic heat cycles
Carquest Premium – Radiator: With Transmission Oil Cooler (Part No.813162)
from
$276.99
Carquest Premium radiators are designed and engineered for maximum performance, using the highest-grade materials to ensure all radiators meet or exceed original equipment (O.E.) fit, form and function. Carquest Premium radiators are built by manufacturers that meet IATF 16949 certified framework, an internationally recognized proof of quality in the automotive industry. Most modern vehicles use radiators with plastic tanks and our parts are engineered with integrated ribbing to prevent damage during thermal cycling. Carquest Premium radiators are also 100% tested to ensure a durable, leak-free cooling system repair.
Product Features:
See More
Product Features:
- Thermal tested under real-life temperature simulations
- High tensile strength aluminum for maximum crimp strength
- Plastic tanks are engineeredáwith integrated ribbingáfor addedástrength to withstand cracks, bowing and distortion during thermal cycles
- Thermal expansion slots extend core life and reduce failure rates by allowing improved core expansion and contraction during systematic heat cycles
Rein – RADIATOR MOUNT (Part No.AVM0738)
from
$4.99
Anti-vibration parts dampen vibration harmonics from the engine and drive line components to rest of the vehicle. This in turn reduces vibration and noise which can be felt and heard while the vehicle is in operation. Rein Automotive anti-vibration parts are application specific and match the design and function of the OE parts.
Product Features:
See More
Product Features:
- Rubber components match the shore hardness of the original equipment bushing to ensure maximum performance and product longevity.
- Part has a high corrosion resistance for maximum life.
- Produced with high quality materials to ensure maximum life and a smooth ride.
- Made by the OE manufacturer.
Dorman – RAD MOUNT BUSHING (Part No.927-245)
from
$17.99
RAD MOUNT BUSHING
Rein – Radiator Mount (Part No.AVM0699)
from
$22.99
Anti-vibration parts dampen vibration harmonics from the engine and drive line components to rest of the vehicle. This in turn reduces vibration and noise which can be felt and heard while the vehicle is in operation. Rein Automotive anti-vibration parts are application specific and match the design and function of the OE parts.
Product Features:
See More
Product Features:
- Rubber components match the shore hardness of the original equipment bushing to ensure maximum performance and product longevity.
- Part has a high corrosion resistance for maximum life.
- Produced with high quality materials to ensure maximum life and a smooth ride.
- Made by the OE manufacturer.
Rein – Expansion Tank (Part No.EPT0029)
from
$63.99
Rein Automotive OE quality expansion tanks, install, fit and perform the way the original manufacturer intended. These tanks are designed to match or exceed the OE materials used and are produced from virgin plastic with no regrind to prevent cracking from heat cycles and ensure the plastic is durable and will have a long service life.
Product Features:
See More
Product Features:
- Produced from virgin plastic meeting/exceeding OE specifications and ensuring long life
- Resistant to cracking and wear from heat cycles preventing coolant loss
- Direct fitment allows easy installation
- Manufactured to strict engineering standards/specifications in materials and tolerances
Dorman – Pressurized Coolant Reservoir: Black and Clear, Plastic, Original Equipment Replacement (Part No.603-257)
from
$65.99
This replacement engine coolant reservoir is manufactured from quality materials to withstand the stresses of underhood heat and engine vibration. It is engineered and manufactured to match the fit and function of the original part.
Product Features:
See More
Product Features:
- Direct replacement – this engine coolant reservoir matches the fit and function of the original part
- Ideal solution – engineered for a seamless installation
- Durable construction – manufactured from quality materials to withstand underhood heat and vibration
- Trustworthy design – backed by 100 years of automotive aftermarket experience
Rein – Expansion Tank (Part No.EPT0132)
from
$63.99
Rein Automotive OE quality expansion tanks, install, fit and perform the way the original manufacturer intended. These tanks are designed to match or exceed the OE materials used and are produced from virgin plastic with no regrind to prevent cracking from heat cycles and ensure the plastic is durable and will have a long service life.
Product Features:
See More
Product Features:
- Produced from virgin plastic meeting/exceeding OE specifications and ensuring long life
- Resistant to cracking and wear from heat cycles preventing coolant loss
- Direct fitment allows easy installation
- Manufactured to strict engineering standards/specifications in materials and tolerances
Carquest Premium – Standard Reservoir Cap: 21 PSI (Part No.10253)
from
$19.99
Crafted to meet the exact specifications set by Original Equipment Manufacturers (OEM), these products are engineered for effortless installation and removal. Constructed from premium-grade components, incorporating proper relief and vacuum valves, they ensure optimal performance even in the most demanding automotive cooling systems. Rigorously quality-tested, these components provide exceptional, out-of-the-box performance and superior durability to meet or exceed the highest standards of today’s vehicles.
Product Features:
See More
Product Features:
- Maintains proper cooling system pressure
- Easy installation and removal
- 100% tested to ensure proper pressure and longevity
- Meets all OEM specifications
Carquest Premium – A/C Desiccant Bag Kit (Part No.T83380)
from
$33.99
Carquest Accumulators and Receiver Driers are designed to store, filter and dry the air conditioning refrigerant to provide proper performance and durability for the air conditioning system. They are manufactured to meet or exceed original equipment specifications.
Product Features:
See More
Product Features:
- All parts meet or exceed original equipment standards for moisture absorption, pressure and temperature resistance, air tightness, vibration resistance, corrosiveness, and pulse pressure.
- Desiccant is 100% tested and assembled in a controlled environment to ensure performance meets or exceeds original equipment standards.
- All accumulators and receiver driers are helium leak tested prior to packaging.
- O-Rings necessary for installation are included.
Carquest Premium – A/C Desiccant Bag Kit (Part No.T83063)
from
$29.99
Carquest Accumulators and Receiver Driers are designed to store, filter and dry the air conditioning refrigerant to provide proper performance and durability for the air conditioning system. They are manufactured to meet or exceed original equipment specifications.
Product Features:
See More
Product Features:
- All parts meet or exceed original equipment standards for moisture absorption, pressure and temperature resistance, air tightness, vibration resistance, corrosiveness, and pulse pressure.
- Desiccant is 100% tested and assembled in a controlled environment to ensure performance meets or exceeds original equipment standards.
- All accumulators and receiver driers are helium leak tested prior to packaging.
- O-Rings necessary for installation are included.
KAI – A/C Condenser (Part No.CND3760)
from
$115.99
New Platinum Pro A/C Condenser, C300/C350/C63 GLK350
Product Features:
See More
Product Features:
- C300/C350/C63 GLK350, Made Of Aluminum
- Meets All Federal Motor Safety Standards
- No Drilling Needed For Installation
- No Modifications Needed For Installation
- Direct Fit Replacement For Your Vehicle
- Same Form Fit And Function As OE
- Check Out The Large Selection Of Parts Available For Your Vehicle
KAI – A/C Condenser (Part No.CNDDPI3159)
from
$97.99
New Platinum Pro A/C Condenser, E Class With Receiver Drier
Product Features:
See More
Product Features:
- E Class With Receiver Drier, Made Of Aluminum
- Meets All Federal Motor Safety Standards
- No Drilling Needed For Installation
- No Modifications Needed For Installation
- Direct Fit Replacement For Your Vehicle
- Same Form Fit And Function As OE
- Check Out The Large Selection Of Parts Available For Your Vehicle
Carquest Premium – New Water Pump (Part No.T3124)
from
$265.99
Carquest Premium water pumps are 100% new, high-quality parts that meet or exceed original equipment (O.E.) specifications. All components, including the housing, hub, bearings, gaskets and seals are designed for long-lasting service life. These water pumps are supplied with the gaskets or seals necessary for installation. Our Carquest Premium water pumps undergo stringent testing to ensure superior performance that we stand behind with an industry-leading warranty.
Product Features:
See More
Product Features:
- 100% tested for reliable performance
- Durable housing features precisely machined mounting surface for proper sealing and fitment
- Equipped with weep chamber or similar feature to help prevent unnecessary replacement
- Included heavy-duty unitized bearings, pressed-on hubs and optimal impeller clearance for a long-lasting water pump
- All gaskets or seals necessary for water pump are included
- This pump is driven by the accessory belt and we recommend replacement if nearing service recommendation
Carquest Premium – New Auxiliary Water Pump (Part No.T1380)
from
$247.99
This new pump is 100% tested to ensure the highest quality. Each unit is built to meet or exceed all OE specifications and is validated for fit, form, and function. Application specific design to ensure a perfect fit and correct operation for unsurpassed quality.
Product Features:
See More
Product Features:
- Electric water pump
- Specialized for vehicles using supplemented cooling for the engine or components
- Plastic housing
- All components necessary for installation are supplied with pump
- Follow all enclosed instructions to maximize pump life and validate warranty
Carquest Premium – Engine Water Pump: New, Gasket/Seals Included (Part No.T3128)
from
$204.99
Carquest Premium water pumps are 100% new, high-quality parts that meet or exceed original equipment (O.E.) specifications. All components, including the housing, hub, bearings, gaskets and seals are designed for long-lasting service life. These water pumps are supplied with the gaskets or seals necessary for installation. Our Carquest Premium water pumps undergo stringent testing to ensure superior performance that we stand behind with an industry-leading warranty.
Product Features:
See More
Product Features:
- 100% tested for reliable performance
- Durable housing features precisely machined mounting surface for proper sealing and fitment
- Equipped with weep chamber or similar feature to help prevent unnecessary replacement
- Included heavy-duty unitized bearings, pressed-on hubs and optimal impeller clearance for a long-lasting water pump
- All gaskets or seals necessary for water pump are included
- This pump is driven by the accessory belt and we recommend replacement if nearing service recommendation
- This pump is driven by the timing chain; see vehicle manufacturer recommendation for replacement of timing components
- This pump is driven by the timing belt; see vehicle manufacturer recommendation for replacement of timing components
Carquest Premium – Engine Water Pump: New, Gasket/Seals Included (Part No.T2288)
from
$179.99
Carquest Premium water pumps are 100% new, high-quality parts that meet or exceed original equipment (O.E.) specifications. All components, including the housing, hub, bearings, gaskets and seals are designed for long-lasting service life. These water pumps are supplied with the gaskets or seals necessary for installation. Our Carquest Premium water pumps undergo stringent testing to ensure superior performance that we stand behind with an industry-leading warranty.
Product Features:
See More
Product Features:
- 100% tested for reliable performance
- Durable housing features precisely machined mounting surface for proper sealing and fitment
- Equipped with weep chamber or similar feature to help prevent unnecessary replacement
- Included heavy-duty unitized bearings, pressed-on hubs and optimal impeller clearance for a long-lasting water pump
- All gaskets or seals necessary for water pump are included
- This pump is driven by the accessory belt and we recommend replacement if nearing service recommendation
- This pump is driven by the timing chain; see vehicle manufacturer recommendation for replacement of timing components
- This pump is driven by the timing belt; see vehicle manufacturer recommendation for replacement of timing components
Carquest Premium – New Compressor with Clutch, Nippondenso 6SAS14C (Part No.T168324)
from
$499.99
New Compressors are built in a ISO9001:2015 Certified facility. These facilities go through several audits to ensure quality standards in the manufacturing process.
Product Features:
See More
Product Features:
- Endurance tested the equivalent of 50k miles
- Includes specific electrical connector to eliminate splicing
- Charged with lubricant to reduce internal friction promoting enhanced system performance and longevity
- For ease of installation this compressor includes a direct fit OE style connector as well as all gaskets, O-rings, or seals needed to repair your car
- Each unit is individually leak, vacuum and pressure tested prior to packaging to ensure leak free performance
- New Compressors meet or exceed OE specifications
- New Compressors are validated for the equivalent of 100,000 miles
- New Compressors come pre-charged with 3 ounces of PAG oil for R134a or R1234yf applications
- New Compressors come with direct fit connectors for ease of installation and to help eliminate splicing
- New Compressors come with the R12/R134A/1234yf required O-rings /sealing washers to install the compressor
DENSO – A/C Compressor with Clutch – New (Part No.471-1593)
from
$528.99
As one of the world’s largest OE suppliers of A/C compressors DENSO units are specified by most major vehicle manufacturers. DENSO First Time Fit A/C compressors are manufactured and tested to the strictest OE standards for unparalleled performance. At DENSO we bring together everything we know as an air conditioning systems manufacturer to bring you the highest quality line of factory-new compressors available. When it comes to new compressors you can’t do better than going with a unit manufactured by the OE supplier. At DENSO we know these units better than anyone because we originally designed them. Our compressors are built to meet DENSO’s unsurpassed reputation for technological superiority. You can relax knowing DENSO will give you the right part and the right fit the first time.
Product Features:
See More
Product Features:
- DENSO is the world’s largest OE supplier of A/C compressors
- Each compressor is precision manufactured for exact replacement
- Designed for high output and extended durability
- Highest quality in the Aftermarket
KAI – A/C Compressor (Part No.ACP012185)
from
$506.99
New Standard Replacement A/C Compressor, V6 Engine
Product Features:
See More
Product Features:
- V6 Engine
- Meets All Federal Motor Safety Standards
- No Drilling Needed For Installation
- No Modifications Needed For Installation
- Direct Fit Replacement For Your Vehicle
- Same Form Fit And Function As OE
- Check Out The Large Selection Of Parts Available For Your Vehicle
Carquest Standard – A/C Remanufactured; w/ Clutch; w/ 7SEU17C Compressor (Part No.DW157360)
from
$453.99
Carquest Standard Remanufactured Compressors are manufactured to meet original equipment specifications. All components are either remanufactured to strict standards or are replaced with new components to ensure performance and durability. All compressors are 100% end of line tested.
Product Features:
See More
Product Features:
- O-Rings and gaskets necessary for installation are included.
- All remanufactured compressors are built using the latest compressor technology available today and using strict remanufacturing processes
- All units have new seals, O-rings, gaskets and clutch bearings
- Tested for noise, vibration, durability, vacuum decay and pressure decay to ensure no leaks and longer life
Carquest Premium – A/C Refrigerant Pressure Sensor (Part No.ACA2004)
from
$41.99
The Carquest Premium line of vehicle electronics are designed for OE form, fit and function for both import and domestic vehicles. The A/C Pressure Sensor reports system pressures to the on-board computer, in turn allowing the computer to properly and efficiently control the compressor, fans and system levels. An improperly functioning A/C Pressure Sensor will provide erratic or inaccurate readings to on-board computers severely affecting system performance and function. Without reliable and accurate data from a properly functioning A/C Pressure Sensor, on-board computers are unable to protect the safety of critical components and the system as a whole which can lead to excessive wear and tear on critical components and costly system damage.
Product Features:
See More
Product Features:
- Designed and manufactured with high quality materials, industry leading electronic components and strict quality controls. Engineered to exceed OE performance and to meet the uncompromising demands of service professionals.
- Direct fit replacement matches proper OE fit, form, and function and ensures trouble free installation of your A/C Pressure Sensor.
- All units are helium leak tested on fully automated mass spectrometer equipment before end-of-line testing.
- All units are tested using automated end-of-line testing equipment that pressurizes the sensor and checks full-spectrum functionality and electrical output to ensure each part meets manufacturing specifications before packaging.
Upgrade your 2022 Mercedes-Benz E350 with Top-Quality Cooling and Climate Controls
When it comes to maintaining or upgrading your 2022 Mercedes-Benz E350, nothing is more important than using high-quality OEM or aftermarket parts that you can trust. Whether you’re repairing damage to your Mercedes-Benz or enhancing its overall performance, Cooling and Climate Controls are key to keeping your E350 functioning at its best. At Advance Auto Parts, we offer a wide selection of 11 Cooling and Climate Controls for the 2022 Mercedes-Benz E350, designed to meet your needs without breaking the bank.
From
Heating Part
replacements to
Engine Cooling Parts
upgrades, we’ve got you covered with parts that fit your vehicle perfectly and ensure long-lasting performance.
Affordable Prices and Wide Selection
Shopping for Cooling and Climate Controls for any vehicle can be a hassle, especially if you’re on a budget. But with Advance Auto Parts, you can find high-quality Cooling and Climate Controls for your 2022 Mercedes-Benz E350 at great prices.
Our Cooling and Climate Controls inventory for this model
ranges from just $17.99 to $499.99, with
an average price of $136.81.
Our 11 Cooling and Climate Controls in stock come from 4 trusted brands, so you’re sure to find the right part for your 2022 Mercedes-Benz E350 without overspending.
Top Brands and High Customer Satisfaction
Advance Auto Parts takes pride in offering only the best brands in the automotive industry. For your 2022 Mercedes-Benz E350, we stock popular OEM and aftermarket Cooling and Climate Controls from top names
like Carquest Premium, and more.
Carquest Premium Cooling and Climate Controls
start at just $19.99 and boast an impressive 4.4 stars average rating from customers.
With 10 customer reviews and counting, our 2022 Mercedes-Benz E350 Cooling and Climate Controls have a strong track record of reliability, ensuring you can trust your purchase.
Explore Related Parts and More
While you’re here, don’t forget to check out other essential categories that go hand in hand with Cooling and Climate Control upgrades. Explore related part types like Oil and Lubricants, Fluids and Chemicals
and more to make sure your 2022 Mercedes-Benz E350 is always ready to roll. We’re committed to providing you with everything you need to keep your E350 in top shape, all in one place.
Start shopping confidently below for your 2022 Mercedes-Benz E350!
Best-Selling Heating Parts for 2022 Mercedes-Benz E350s
Enhance the driving experience in your Mercedes-Benz with 1 quality Heating Part components, starting at $76.99.
Carquest Premium – Heater Core (Part No.910568)
from
$76.99
Carquest Premium offers a complete line of automotive heater cores covering 94% of all North American vehicle applications. Carquest Premium provides value in several ways, including increased thermal performance and resistance to corrosion using enhanced design features, such as the latest fin and tube technology and design standardization for maximum availability. Carquest Premium offers certified heater cores that meet or exceed OE specifications and are all fitment checked in the actual vehicle’s HVAC heater module and are, thus, ready to be installed right out of the box for a “Drop-In Fit”. Carquest Premium heater cores are engineered and manufactured under ISO TS16949 quality systems and are 100% leak tested.
Product Features:
See More
Product Features:
- All heater cores are designed and tested to match or exceed OE specifications for form, fit and performance with a clear focus on obtaining the highest heat transfer performance possible through use of quality materials and manufacturing processes to ensu
- Carquest Premium heater cores are engineered and manufactured under ISO TS16949 quality systems and are 100% leak tested.
- Provides value in several ways, including increased thermal performance and resistance to corrosion using enhanced design features, such as the latest fin and tube technology and design standardization for maximum availability.
- Carquest Premium offers a complete line of automotive heater cores covering 94% of all North American vehicle applications.
- Our advanced engineering methods coupled with our innovative manufacturing technology provides products to the aftermarket that meet or exceed form, fit, and function of OEM Parts
Most Popular 2022 Mercedes-Benz E350 Engine Cooling Parts
Customize your Mercedes-Benz with 6 Engine Cooling Parts products
like Radiators,
Water Pumps, and
Coolant Reservoir Caps, all
priced under $399.99.
Carquest Premium – Standard Reservoir Cap: 21 PSI (Part No.10253)
from
$19.99
Crafted to meet the exact specifications set by Original Equipment Manufacturers (OEM), these products are engineered for effortless installation and removal. Constructed from premium-grade components, incorporating proper relief and vacuum valves, they ensure optimal performance even in the most demanding automotive cooling systems. Rigorously quality-tested, these components provide exceptional, out-of-the-box performance and superior durability to meet or exceed the highest standards of today’s vehicles.
Product Features:
See More
Product Features:
- Maintains proper cooling system pressure
- Easy installation and removal
- 100% tested to ensure proper pressure and longevity
- Meets all OEM specifications
Carquest Premium – Radiator (Part No.4113975)
from
$399.99
A global leader in the manufacture and distribution of aftermarket cooling products for automotive, heavy truck, and industrial applications. Specialized in the production of OE-quality Radiators, Condensers, and Charge Air Coolers for US and international markets, covering over 10,000 part numbers worldwide.
Product Features:
See More
Product Features:
- We design and manufacture all our radiators to meet or even exceed Original Equipment specifications. We take pride in producing the most reliable replacement parts in the market.
- Thermal expansion cuts allow for longer life and reduced failure rates by allowing improved core expansion and contraction during normal heat cycles.
- Our B-Type tubes feature central reinforcement to provide greater tolerance to pressure. Stronger tube design means drastically reduced probability of tube failure.
- We use longer header tabs for increased pressure resistance. This reduces the potential for tank to header leaks.
- Our deep extrusion header provides a stronger tube to header joint which is more resistant to the effects of vibration and thermal tube expansion, virtually eliminating tube to header leaks.
- Our fin edges are folded for increased stability and heat disbursement properties.
- Our included “multi-fit” attachments allow one radiator to cover multiple vehicle applications without sacrificing OE fit. This results in wider vehicle coverage with substantially less inventory.
Carquest Premium – New Auxiliary Water Pump (Part No.T1380)
from
$247.99
This new pump is 100% tested to ensure the highest quality. Each unit is built to meet or exceed all OE specifications and is validated for fit, form, and function. Application specific design to ensure a perfect fit and correct operation for unsurpassed quality.
Product Features:
See More
Product Features:
- Electric water pump
- Specialized for vehicles using supplemented cooling for the engine or components
- Plastic housing
- All components necessary for installation are supplied with pump
- Follow all enclosed instructions to maximize pump life and validate warranty
Rein – Expansion Tank (Part No.EPT0132)
from
$63.99
Rein Automotive OE quality expansion tanks, install, fit and perform the way the original manufacturer intended. These tanks are designed to match or exceed the OE materials used and are produced from virgin plastic with no regrind to prevent cracking from heat cycles and ensure the plastic is durable and will have a long service life.
Product Features:
See More
Product Features:
- Produced from virgin plastic meeting/exceeding OE specifications and ensuring long life
- Resistant to cracking and wear from heat cycles preventing coolant loss
- Direct fitment allows easy installation
- Manufactured to strict engineering standards/specifications in materials and tolerances
Rein – Radiator Mount (Part No.AVM0699)
from
$22.99
Anti-vibration parts dampen vibration harmonics from the engine and drive line components to rest of the vehicle. This in turn reduces vibration and noise which can be felt and heard while the vehicle is in operation. Rein Automotive anti-vibration parts are application specific and match the design and function of the OE parts.
Product Features:
See More
Product Features:
- Rubber components match the shore hardness of the original equipment bushing to ensure maximum performance and product longevity.
- Part has a high corrosion resistance for maximum life.
- Produced with high quality materials to ensure maximum life and a smooth ride.
- Made by the OE manufacturer.
Dorman – RAD MOUNT BUSHING (Part No.927-245)
from
$17.99
RAD MOUNT BUSHING
Top Picks for 2022 Mercedes-Benz E350 Air Conditioning Parts
Upgrade Mercedes-Benz E350s with top-quality Air Conditioning Parts parts, including 4 OEM and aftermarket selections for your 2022 model.
Carquest Premium – New Compressor with Clutch, Nippondenso 6SAS14C (Part No.T168324)
from
$499.99
New Compressors are built in a ISO9001:2015 Certified facility. These facilities go through several audits to ensure quality standards in the manufacturing process.
Product Features:
See More
Product Features:
- Endurance tested the equivalent of 50k miles
- Includes specific electrical connector to eliminate splicing
- Charged with lubricant to reduce internal friction promoting enhanced system performance and longevity
- For ease of installation this compressor includes a direct fit OE style connector as well as all gaskets, O-rings, or seals needed to repair your car
- Each unit is individually leak, vacuum and pressure tested prior to packaging to ensure leak free performance
- New Compressors meet or exceed OE specifications
- New Compressors are validated for the equivalent of 100,000 miles
- New Compressors come pre-charged with 3 ounces of PAG oil for R134a or R1234yf applications
- New Compressors come with direct fit connectors for ease of installation and to help eliminate splicing
- New Compressors come with the R12/R134A/1234yf required O-rings /sealing washers to install the compressor
KAI – A/C Condenser (Part No.CND4742)
from
$78.99
New Platinum Pro A/C Condenser
Product Features:
See More
Product Features:
- Made Of Aluminum
- Meets All Federal Motor Safety Standards
- No Drilling Needed For Installation
- No Modifications Needed For Installation
- Direct Fit Replacement For Your Vehicle
- Same Form Fit And Function As OE
- Check Out The Large Selection Of Parts Available For Your Vehicle
Carquest Premium – A/C Refrigerant Pressure Sensor (Part No.ACA2004)
from
$41.99
The Carquest Premium line of vehicle electronics are designed for OE form, fit and function for both import and domestic vehicles. The A/C Pressure Sensor reports system pressures to the on-board computer, in turn allowing the computer to properly and efficiently control the compressor, fans and system levels. An improperly functioning A/C Pressure Sensor will provide erratic or inaccurate readings to on-board computers severely affecting system performance and function. Without reliable and accurate data from a properly functioning A/C Pressure Sensor, on-board computers are unable to protect the safety of critical components and the system as a whole which can lead to excessive wear and tear on critical components and costly system damage.
Product Features:
See More
Product Features:
- Designed and manufactured with high quality materials, industry leading electronic components and strict quality controls. Engineered to exceed OE performance and to meet the uncompromising demands of service professionals.
- Direct fit replacement matches proper OE fit, form, and function and ensures trouble free installation of your A/C Pressure Sensor.
- All units are helium leak tested on fully automated mass spectrometer equipment before end-of-line testing.
- All units are tested using automated end-of-line testing equipment that pressurizes the sensor and checks full-spectrum functionality and electrical output to ensure each part meets manufacturing specifications before packaging.
Carquest Premium – A/C Desiccant Bag Kit (Part No.T83380)
from
$33.99
Carquest Accumulators and Receiver Driers are designed to store, filter and dry the air conditioning refrigerant to provide proper performance and durability for the air conditioning system. They are manufactured to meet or exceed original equipment specifications.
Product Features:
See More
Product Features:
- All parts meet or exceed original equipment standards for moisture absorption, pressure and temperature resistance, air tightness, vibration resistance, corrosiveness, and pulse pressure.
- Desiccant is 100% tested and assembled in a controlled environment to ensure performance meets or exceeds original equipment standards.
- All accumulators and receiver driers are helium leak tested prior to packaging.
- O-Rings necessary for installation are included.
Top-Rated Cooling and Climate Controls Brands For Your 2022 Mercedes-Benz E350
Shop for the best-rated brands offering Cooling and Climate Controls and other products for your 2022 Mercedes-Benz E350s. Below you’ll find some of our best rated Cooling and Climate Controls from Carquest Premium, and more. Cooling and Climate Controls from these brands that fit a 2022 E350 start at just $19.99 and are rated as high as 4.4 stars. OEM and aftermarket Cooling and Climate Controls don’t get more top quality, durable, and affordable than from the brands below.
Popular Carquest Premium 2022 Mercedes-Benz E350 Cooling and Climate Controls
When it comes to maintaining or upgrading your 2022 Mercedes-Benz E350, using quality Cooling and Climate Controls is essential to ensure durability and a perfect fit. Carquest Premium ticks all of those boxes. We offer a wide selection of Carquest Premium Cooling and Climate Controls, specifically designed for the 2022 Mercedes-Benz E350. With over 1 Carquest Premium brand Cooling and Climate Controls in stock, you’re sure to find what you need. The prices for these top-notch parts start as low as $19.99. Plus, with over 1 customer reviews and an average rating of 4.4 stars, you can trust that our Carquest Premium Cooling and Climate Controls will get the job done right. Choose Advance Auto Parts for reliability, quality, and expert-approved parts that keep your vehicle running strong.
FAQs for 2022 Mercedes-Benz E350 Cooling and Climate Controls
Which Cooling and Climate Controls are best-sellers for 2022 Mercedes-Benz E350s?
Out of 11 Cooling and Climate Controls that fit 2022 Mercedes-Benz E350s, the following parts are the top sellers:
- A/C Desiccant Bag Kit (12092891) – $33.99
- Radiator Mount (11909827) – $22.99
- RAD MOUNT BUSHING (50232604) – $17.99
What’s the price range for 2022 Mercedes-Benz E350 Cooling and Climate Controls?
Cooling and Climate Control prices for the 2022 Mercedes-Benz E350 start at $17.99 and go up to $499.99 for the most premium parts.
What’s the average price of a Cooling and Climate Control for a 2022 Mercedes-Benz E350?
The average price for Cooling and Climate Controls for the 2022 Mercedes-Benz E350 is $136.81. Keep in mind the variety of part types within our Cooling and Climate Control category so you are likely to find a wide range of prices across a variety of parts and components.
Does Advance Auto Parts sell Cooling and Climate Controls for other Mercedes-Benz E350 model years?
What are the cheapest Cooling and Climate Controls for my 2022 Mercedes-Benz E350?
The cheapest 2022 Mercedes-Benz E350 Cooling and Climate Controls we carry in stock are:
- RAD MOUNT BUSHING (50232604) – $17.99
- Standard Reservoir Cap: 21 PSI (15480047) – $19.99
- Radiator Mount (11909827) – $22.99
- A/C Desiccant Bag Kit (12092891) – $33.99
- A/C Refrigerant Pressure Sensor (12541630) – $41.99
What are the top-rated Cooling and Climate Controls that fit the 2022 Mercedes-Benz E350?
Out of 10 reviews by customers, our 2022 Mercedes-Benz E350 Cooling and Climate Controls have an average customer rating of . These are some of the highest-rated Cooling and Climate Control types for the 2022 Mercedes-Benz E350 and their top-rated products:
- Engine Cooling Parts
- Standard Reservoir Cap: 21 PSI (15480047) – $19.99
- Heating Parts
- Standard Reservoir Cap: 21 PSI (15480047) – $19.99
What types of Cooling and Climate Controls do you sell for my 2022 Mercedes-Benz E350?
As of 11/2/25, these are some of the most in-demand types of Cooling and Climate Controls for a 2022 Mercedes-Benz E350:
Can I get help with 2022 Mercedes-Benz E350 Cooling and Climate Control orders?
Contact our customer support team, by chat or phone, through the help desk page, where you can find instant answers about Mercedes-Benz Cooling and Climate Controls and more.
What is your return policy for Mercedes-Benz E350 Cooling and Climate Controls?
Advance Auto Parts keeps returns simple. For new Mercedes-Benz E350 Cooling and Climate Controls and accessories, your online orders can be returned, in their original condition, within 45 days. For requirements, see the returns page.
