2022 Lexus RX350 Drivetrains

Essential Drivetrains for 2022 Lexus RX350s

Carquest Premium – CV Axle Shaft Assembly (Part No.NCV69535)

CV Axle Shaft Assembly

from

$104.99
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Product Features:
  • Designed to meet or exceed OE specifications for fit, form and function
  • 100% new axle and components
  • New axle nut or attaching hardware included when applicable
  • Bearings, races and housings are heat-treated for longer life
  • Precision-engineered seal mating surfaces for leak-free performance
  • High moly CV joint grease with stainless-steel boot bands
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Carquest Premium – New CV Axle Assembly (Part No.NCV518618)

New CV Axle Assembly

from

$95.99
Manufactured to be an OE replacement, CV axles use 100% new materials and are engineered for ease of installation and long service.

Product Features:
  • All New Materials
  • Engineered for OE Fitment
  • -40 Degree Rated CV Boots
  • Moly-Blend Grease in inner and outer joints
  • New nut and mounting hardware included if required
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Carquest Premium – CV Axle Shaft Assembly (Part No.NCV69500)

CV Axle Shaft Assembly

from

$109.99
Carquest Premium constant velocity (C.V.) axle shaft assemblies are 100% new units that are designed to meet or exceed OE specifications. Every part number is tested to guarantee a proper fit and reliable performance. Carquest Premium CV axles are assembled with a specially formulated high-temperature moly grease to resist friction and wear of the bearings and joints. Our strict engineering and quality specifications ensure a long-lasting repair that is guaranteed with an industry-leading warranty.

Product Features:
  • Designed to meet or exceed OE specifications for fit, form and function
  • 100% new axle and components
  • New axle nut or attaching hardware included when applicable
  • Bearings, races and housings are heat-treated for longer life
  • Precision-engineered seal mating surfaces for leak-free performance
  • High moly CV joint grease with stainless-steel boot bands
See More

Carquest Premium – CV Axle Shaft Assembly (Part No.NCV905671)

CV Axle Shaft Assembly

from

$103.99
Carquest Premium constant velocity (C.V.) axle shaft assemblies are 100% new units that are designed to meet or exceed OE specifications. Every part number is tested to guarantee a proper fit and reliable performance. Carquest Premium CV axles are assembled with a specially formulated high-temperature moly grease to resist friction and wear of the bearings and joints. Our strict engineering and quality specifications ensure a long-lasting repair that is guaranteed with an industry-leading warranty.

Product Features:
  • Designed to meet or exceed OE specifications for fit, form and function
  • 100% new axle and components
  • New axle nut or attaching hardware included when applicable
  • Bearings, races and housings are heat-treated for longer life
  • Precision-engineered seal mating surfaces for leak-free performance
  • High moly CV joint grease with stainless-steel boot bands
See More

EMPI – Axle Shaft Nut (Part No.K403059357EMP)

Axle Shaft Nut

from

$5.11
The EMPI Axle Shaft Nut is an ideal high quality aftermarket replacement that is manufactured to meet or exceed OE specifications for fit, form, and function.

Product Features:
  • Premium aftermarket replacement
  • Provides performance and dependability
  • Manufactured to meet OE specifications
See More

Dorman – Spindle Nut (Part No.K1002751713DOR)

Spindle Nut

from

$17.46
Spindle Nut

Dorman – Spindle Nut M22-1.50 Hex Star Pattern (sold by each) (Part No.615-224)

Spindle Nut M22-1.50 Hex Star Pattern (sold by each)

from

$8.49
This spindle nut is designed to match the fit and function of the original part on specified vehicles. Made of quality materials, it is engineered for reliable performance.

Product Features:
  • Direct replacement – this spindle nut matches the fit and function of the factory part on specified years, makes and models.
  • Ideal solution – this nut is a reliable replacement for an original part that is missing or has failed due to fatigue
  • Durable construction – this part is made from quality materials to ensure reliable performance and long service life
  • Trustworthy quality – backed by team of product experts in the United States and more than a century of automotive experience
See More

National – Multi Purpose Seal (Part No.710807)

Multi Purpose Seal

from

$25.49
National has built a reputation as one of the most respected names in the industry. We have offered premium sealing solutions for more than 75 years. Our design team keeps pace with the industry and provides advanced solutions for today’s vehicles.

Product Features:
  • Low swell in hydrocarbon fluids
  • Design type: spring loaded; multi-lip
  • Provides good low temperature capability
  • Temperature range: -40°F to 225°F; -40°C to 107°C
  • Delivers quality and reliable performance for every type of repair
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National – Multi Purpose Seal (Part No.711075)

Multi Purpose Seal

from

$11.79
Multi Purpose Seal

National – Oil Seal (Part No.710954)

Oil Seal

from

$11.49
National has built a reputation as one of the most respected names in the industry. We have offered premium sealing solutions for more than 75 years. Our design team keeps pace with the industry and provides advanced solutions for today’s vehicles.
See More

Ishino Stone – TRANS CASE OUTPUT SF (Part No.J7121452626ISH)

TRANS CASE OUTPUT SF

from

$11.16
TRANS CASE OUTPUT SF

National – Multi Purpose Seal (Part No.710870)

Multi Purpose Seal

from

$11.99
National has built a reputation as one of the most respected names in the industry. We have offered premium sealing solutions for more than 75 years. Our design team keeps pace with the industry and provides advanced solutions for today’s vehicles.

Product Features:
  • Low swell in hydrocarbon fluids
  • Design type: spring loaded; multi-lip
  • Provides good low temperature capability
  • Temperature range: -40°F to 225°F; -40°C to 107°C
  • Delivers quality and reliable performance for every type of repair
See More

Driveworks – Manual Transmission Output Shaft Seal (Part No.S-710319)

Manual Transmission Output Shaft Seal

from

$3.49
Product Features:
  • Brand may vary by location
See More

Dorman – Driveshaft Center Support Bearing (Part No.934-404)

Driveshaft Center Support Bearing

from

$95.99
This drive shaft center bearing is designed to match the fit and function of the original bearing on specified vehicles, and is engineered for durability and reliable performance.

Product Features:
  • Direct replacement – this drive shaft center bearing is designed to match the fit and function of the original bearing on specified vehicles.
  • Restores functionality – this bearing is made to fit and fully restore part functionality after the original bearing fails.
  • Durable construction – this part is made from quality materials to ensure reliable performance and long service life
  • Trustworthy quality – backed by team of product experts in the United States and more than a century of automotive experience
See More

Dorman – Driveshaft Center Support Bearing (Part No.934-405)

Driveshaft Center Support Bearing

from

$94.99
This drive shaft center bearing is designed to match the fit and function of the original bearing on specified vehicles, and is engineered for durability and reliable performance.

Product Features:
  • Direct replacement – this drive shaft center bearing is designed to match the fit and function of the original bearing on specified vehicles.
  • Restores functionality – this bearing is made to fit and fully restore part functionality after the original bearing fails.
  • Durable construction – this part is made from quality materials to ensure reliable performance and long service life
  • Trustworthy quality – backed by team of product experts in the United States and more than a century of automotive experience
See More

Anchor – Center Support Bearing Motor Mount: Rear, Center, 1 Piece (Part No.6082)

Center Support Bearing Motor Mount: Rear, Center, 1 Piece

from

$119.99
Center support bearings or Carrier Support Bearings are used when the driveshaft is split into two sections. It serves as a junction on the drive shaft between the transmission and the differential allowing the driveshaft to flex, relieving stress on other drive line components. Each part is engineered and designed to OE Standards. Applicable to LEXUS 99-20; TOYOTA 01-20;. Please verify your application.

Product Features:
  • MAXIMUM VIBRATION DAMPENING: Rubber cushion is made of high grade rubber that ensures maximum dampening of vibration and the ability to absorb over loads.
  • HEAVY GAUGE STEEL FRAME: The housing frame is made from heavy gauge steel with durability that extends the service life.
  • READY TO INSTALL: Most center supports include a sealed bearing and dust shield and are ready to install.
  • For Years: 1999-2020
  • Weight approx: 2 Lbs
  • BEARING ID / BORE: 1.1811 INCH / 30 MM
  • CENTERLINE: 0.10 INCH / 3 MM
  • MOUNT WIDTH: 7.00 INCH / 178 MM
  • STYLE: ROUND FRAME
  • WITH WINGS
  • WITH ELEVATED MOUNTING PLATFORM
See More

SKF – Driveshaft Support with Bearing (Part No.K1030158090SKF)

Driveshaft Support with Bearing

from

$228.02
Rugged SKF drive shaft support bearings are built to meet or exceed OE specifications. They are also built on the years of experience that SKF has earned designing and supplying bearings to the world’s largest OE manufacturers. Engineered and manufactured to specific application requirements that deliver precise drive shaft alignment and support. Center support bearings are pre-lubricated and sealed with metal reinforced seals to prevent contamination. Rubber support cushions are manufactured from durable rubber compounds that provide maximum support while isolating the driveline shaft from damaging vibration. Drive shaft support frames are constructed from high quality steel or aluminum that provides additional strength and long life in harsh environments.

Product Features:
  • OE Quality, fit and performance
  • Precise driveshaft alignment and support
  • Pre-lubricated and sealed
  • Metal reinforced seals to prevent contamination
  • Manufactured from durable rubber compounds
See More

Anchor – Center Support Bearing Motor Mount: Front, 1 Piece (Part No.6083)

Center Support Bearing Motor Mount: Front, 1 Piece

from

$108.99
Center support bearings or Carrier Support Bearings are used when the driveshaft is split into two sections. It serves as a junction on the drive shaft between the transmission and the differential allowing the driveshaft to flex, relieving stress on other drive line components. Each part is engineered and designed to OE Standards. Applicable to LEXUS 01-20; TOYOTA 01-19;. Please verify your application.

Product Features:
  • MAXIMUM VIBRATION DAMPENING: Rubber cushion is made of high grade rubber that ensures maximum dampening of vibration and the ability to absorb over loads.
  • HEAVY GAUGE STEEL FRAME: The housing frame is made from heavy gauge steel with durability that extends the service life.
  • READY TO INSTALL: Most center supports include a sealed bearing and dust shield and are ready to install.
  • For Years: 2001-2020
  • Weight approx: 2 Lbs
  • BEARING ID / BORE: 1.1811 INCH / 30 MM
  • CENTERLINE: 0.10 INCH / 3 MM
  • MOUNT WIDTH: 7.00 INCH / 178 MM
  • STYLE: ROUND FRAME
  • WITH WINGS
See More

Dorman – Rear Drive Shaft (Part No.946-164)

Rear Drive Shaft

from

$1185.99
Replacing a drive shaft doesn’t have to be complicated. This complete drive shaft assembly is pre-balanced and ready to install with 100% new yokes, tubes, constant velocity (CV) joints and universal joints.

Product Features:
  • Direct replacement – this drive shaft is made to the original equipment dimensions for dependable fit and performance.
  • 100% new – this drive shaft is made from all new components so there’s no core charge or return hassle.
  • Ready to install – this drive shaft arrives pre-balanced to make installation quick and simple
  • Serviceable construction – non-staked universal joints are designed for future serviceability
See More

Dorman – Rear Drive Shaft: Adjustable (Part No.976-535)

Rear Drive Shaft: Adjustable

from

$1676.99
Replacing a drive shaft doesn’t have to be complicated. This complete drive shaft assembly is pre-balanced and ready to install with 100% new yokes, tubes, constant velocity (CV) joints and universal joints.

Product Features:
  • Direct replacement – this drive shaft is made to the original equipment dimensions for dependable fit and performance.
  • 100% new – this drive shaft is made from all new components so there’s no core charge or return hassle.
  • Ready to install – this drive shaft arrives pre-balanced to make installation quick and simple
  • Serviceable construction – non-staked universal joints are designed for future serviceability
See More

Cardone – Drive Shaft: Not Greasable, Direct Replacement (Part No.65-5042)

Drive Shaft: Not Greasable, Direct Replacement

from

$818.99
CARDONE Remanufactured Prop Shafts are engineered using the most stringent quality processes to deliver smooth, consistent performance in any driving condition. Original designs are scrutinized for potential improvement, and where applicable, design upgrades are implemented to produce a more durable part than the original. All critical components are tested to ensure proper function. Additionally, all CARDONE Prop Shafts are 100% dynamically balanced, resulting in vibration-free performance at all speeds.

Product Features:
  • Built to match O.E. form, fit and function.
  • 100% NEW universal joints are installed to ensure proper fit and optimal performance.
  • All slip yokes are lubricated to prevent premature wear.
  • Units are 100% dynamically balanced at 3200 RPMs for vibration-free operation and increased joint life.
See More

Cardone – Drive Shaft: Not Greasable, Direct Replacement (Part No.65-5036)

Drive Shaft: Not Greasable, Direct Replacement

from

$1257.99
CARDONE Remanufactured Prop Shafts are engineered using the most stringent quality processes to deliver smooth, consistent performance in any driving condition. Original designs are scrutinized for potential improvement, and where applicable, design upgrades are implemented to produce a more durable part than the original. All critical components are tested to ensure proper function. Additionally, all CARDONE Prop Shafts are 100% dynamically balanced, resulting in vibration-free performance at all speeds.

Product Features:
  • Built to match O.E. form, fit and function.
  • 100% NEW universal joints are installed to ensure proper fit and optimal performance.
  • All slip yokes are lubricated to prevent premature wear.
  • Units are 100% dynamically balanced at 3200 RPMs for vibration-free operation and increased joint life.
See More

Cardone – Drive Shaft: Not Greasable, Direct Replacement (Part No.65-5008)

Drive Shaft: Not Greasable, Direct Replacement

from

$1169.99
CARDONE Remanufactured Prop Shafts are engineered using the most stringent quality processes to deliver smooth, consistent performance in any driving condition. Original designs are scrutinized for potential improvement, and where applicable, design upgrades are implemented to produce a more durable part than the original. All critical components are tested to ensure proper function. Additionally, all CARDONE Prop Shafts are 100% dynamically balanced, resulting in vibration-free performance at all speeds.

Product Features:
  • Built to match O.E. form, fit and function.
  • 100% NEW universal joints are installed to ensure proper fit and optimal performance.
  • All slip yokes are lubricated to prevent premature wear.
  • Units are 100% dynamically balanced at 3200 RPMs for vibration-free operation and increased joint life.
See More

Upgrade your 2022 Lexus RX350 with Top-Quality Drivetrains

When it comes to maintaining or upgrading your 2022 Lexus RX350, nothing is more important than using high-quality OEM or aftermarket parts that you can trust. Whether you’re repairing damage to your Lexus or enhancing its overall performance, Drivetrains are key to keeping your RX350 functioning at its best. At Advance Auto Parts, we offer a wide selection of 7 Drivetrains for the 2022 Lexus RX350, designed to meet your needs without breaking the bank. From Spindle replacements to Drive Shafts and Axles upgrades, we’ve got you covered with parts that fit your vehicle perfectly and ensure long-lasting performance.

Affordable Prices and Wide Selection

Shopping for Drivetrains for any vehicle can be a hassle, especially if you’re on a budget. But with Advance Auto Parts, you can find high-quality Drivetrains for your 2022 Lexus RX350 at great prices. Our Drivetrains inventory for this model ranges from just $5.11 to $818.99, with an average price of $181.75. Our 7 Drivetrains in stock come from 6 trusted brands, so you’re sure to find the right part for your 2022 Lexus RX350 without overspending.

Explore Related Parts and More

While you’re here, don’t forget to check out other essential categories that go hand in hand with Drivetrain upgrades. Explore related part types like Batteries and Chargers, Oil and Lubricants and more to make sure your 2022 Lexus RX350 is always ready to roll. We’re committed to providing you with everything you need to keep your RX350 in top shape, all in one place. Start shopping confidently below for your 2022 Lexus RX350!

Best-Selling Spindles for 2022 Lexus RX350s

Enhance the driving experience in your Lexus with 1 quality Spindle components, starting at $8.49.

Dorman – Spindle Nut M22-1.50 Hex Star Pattern (sold by each) (Part No.615-224)

Spindle Nut M22-1.50 Hex Star Pattern (sold by each)

from

$8.49
This spindle nut is designed to match the fit and function of the original part on specified vehicles. Made of quality materials, it is engineered for reliable performance.

Product Features:
  • Direct replacement – this spindle nut matches the fit and function of the factory part on specified years, makes and models.
  • Ideal solution – this nut is a reliable replacement for an original part that is missing or has failed due to fatigue
  • Durable construction – this part is made from quality materials to ensure reliable performance and long service life
  • Trustworthy quality – backed by team of product experts in the United States and more than a century of automotive experience
See More

Most Popular 2022 Lexus RX350 Drive Shafts and Axles

Customize your Lexus with 5 Drive Shafts and Axles products like Drive Shaft and Axles, Center Support Bearings, and Drive and Prop Shaft Assemblies, all priced under $818.99.

Carquest Premium – CV Axle Shaft Assembly (Part No.NCV519483)

CV Axle Shaft Assembly

from

$182.99
Carquest Premium constant velocity (C.V.) axle shaft assemblies are 100% new units that are designed to meet or exceed OE specifications. Every part number is tested to guarantee a proper fit and reliable performance. Carquest Premium CV axles are assembled with a specially formulated high-temperature moly grease to resist friction and wear of the bearings and joints. Our strict engineering and quality specifications ensure a long-lasting repair that is guaranteed with an industry-leading warranty.

Product Features:
  • Designed to meet or exceed OE specifications for fit, form and function
  • 100% new axle and components
  • New axle nut or attaching hardware included when applicable
  • Bearings, races and housings are heat-treated for longer life
  • Precision-engineered seal mating surfaces for leak-free performance
  • High moly CV joint grease with stainless-steel boot bands
See More

Dorman – Spindle Nut (Part No.K1002751713DOR)

Spindle Nut

from

$17.46
Spindle Nut

Cardone – Drive Shaft: Not Greasable, Direct Replacement (Part No.65-5042)

Drive Shaft: Not Greasable, Direct Replacement

from

$818.99
CARDONE Remanufactured Prop Shafts are engineered using the most stringent quality processes to deliver smooth, consistent performance in any driving condition. Original designs are scrutinized for potential improvement, and where applicable, design upgrades are implemented to produce a more durable part than the original. All critical components are tested to ensure proper function. Additionally, all CARDONE Prop Shafts are 100% dynamically balanced, resulting in vibration-free performance at all speeds.

Product Features:
  • Built to match O.E. form, fit and function.
  • 100% NEW universal joints are installed to ensure proper fit and optimal performance.
  • All slip yokes are lubricated to prevent premature wear.
  • Units are 100% dynamically balanced at 3200 RPMs for vibration-free operation and increased joint life.
See More

SKF – Driveshaft Support with Bearing (Part No.K1030158090SKF)

Driveshaft Support with Bearing

from

$228.02
Rugged SKF drive shaft support bearings are built to meet or exceed OE specifications. They are also built on the years of experience that SKF has earned designing and supplying bearings to the world’s largest OE manufacturers. Engineered and manufactured to specific application requirements that deliver precise drive shaft alignment and support. Center support bearings are pre-lubricated and sealed with metal reinforced seals to prevent contamination. Rubber support cushions are manufactured from durable rubber compounds that provide maximum support while isolating the driveline shaft from damaging vibration. Drive shaft support frames are constructed from high quality steel or aluminum that provides additional strength and long life in harsh environments.

Product Features:
  • OE Quality, fit and performance
  • Precise driveshaft alignment and support
  • Pre-lubricated and sealed
  • Metal reinforced seals to prevent contamination
  • Manufactured from durable rubber compounds
See More

EMPI – Axle Shaft Nut (Part No.K403059357EMP)

Axle Shaft Nut

from

$5.11
The EMPI Axle Shaft Nut is an ideal high quality aftermarket replacement that is manufactured to meet or exceed OE specifications for fit, form, and function.

Product Features:
  • Premium aftermarket replacement
  • Provides performance and dependability
  • Manufactured to meet OE specifications
See More

Top Picks for 2022 Lexus RX350 Transfer Cases

Upgrade Lexus RX350s with top-quality Transfer Cases parts, including 1 OEM and aftermarket selections for your 2022 model.

Ishino Stone – TRANS CASE OUTPUT SF (Part No.J7121452626ISH)

TRANS CASE OUTPUT SF

from

$11.16
TRANS CASE OUTPUT SF

FAQs for 2022 Lexus RX350 Drivetrains

Which Drivetrains are best-sellers for 2022 Lexus RX350s?

Out of 7 Drivetrains that fit 2022 Lexus RX350s, the following parts are the top sellers:

What’s the price range for 2022 Lexus RX350 Drivetrains?

Drivetrain prices for the 2022 Lexus RX350 start at $5.11 and go up to $818.99 for the most premium parts.

What’s the average price of a Drivetrain for a 2022 Lexus RX350?

The average price for Drivetrains for the 2022 Lexus RX350 is $181.75. Keep in mind the variety of part types within our Drivetrain category so you are likely to find a wide range of prices across a variety of parts and components.

Does Advance Auto Parts sell Drivetrains for other Lexus RX350 model years?

Yes, we currently carry Drivetrains for 18 model years of Lexus RX350s between 2007 and 2025. Drivetrains are bought most frequently for the following model years: 2021, 2020, 2019, 2018, 2017, 2016, 2015, 2014, and 2013.

What are the cheapest Drivetrains for my 2022 Lexus RX350?

The cheapest 2022 Lexus RX350 Drivetrains we carry in stock are:

What types of Drivetrains do you sell for my 2022 Lexus RX350?

As of 2/5/25, these are some of the most in-demand types of Drivetrains for a 2022 Lexus RX350:

Can I get help with 2022 Lexus RX350 Drivetrain orders?

Contact our customer support team, by chat or phone, through the help desk page, where you can find instant answers about Lexus Drivetrains and more.

What is your return policy for Lexus RX350 Drivetrains?

Advance Auto Parts keeps returns simple. For new Lexus RX350 Drivetrains and accessories, your online orders can be returned, in their original condition, within 45 days. For requirements, see the returns page.