2022 Ford E-350 Super Duty Engine Cooling Parts
Keep Your 2022 Ford E-350 Super Duty in Top Shape with Quality Engine Cooling Parts
Whether you’re repairing or upgrading your Engine Cooling Part, using high-quality parts is key to keeping your 2022 Ford E-350 Super Duty looking sharp and performing at its best. At Advance Auto Parts we carry a wide selection of dependable options, including Coolant Reservoir Caps, Thermostats, and Radiators. Whether you’re replacing a damaged part or enhancing your truck’s style and protection, you’ll find exactly what you need to get the job done right.
Top-Rated Engine Cooling Parts from Trusted Brands
Looking for a reliable Engine Cooling Part? We’ve got you covered with options from brands you know and trust like FELPRO, Dorman, and Carquest Premium. For example, FELPRO Engine Cooling Parts start at just $10.99 with an average 4.6 star rating. Dorman and Carquest Premium offer similar pricing and quality, backed by strong customer feedback. With over 142 reviews and a solid 4 star average, you can shop with confidence knowing other Ford E-350 Super Duty owners approve.
Competitive Prices and Extensive Inventory
The average price for a 2022 Ford E-350 Super Duty Engine Cooling Part at Advance Auto Parts is around $81.03, with a range that starts at $2.99 and goes up to $449.99. With 7 options in stock from 4 trusted brands, finding the right fit is easy. Popular picks like Standard Reservoir Cap: 16 PSI, Radiator Cap, and Standard Thermostat: With Seal, 192 Degrees start at just $10.99 and offer a great balance of form and function.
Explore Related Parts
While you’re upgrading or replacing your Engine Cooling Part, don’t forget to check out other key components like Blend Doors and Blower Motor and Related Products. At Advance Auto Parts, we’re here to help you keep your 2022 Ford E-350 Super Duty in peak condition, inside and out.
Find Your Specific 2022 Ford E-350 Super Duty Engine Cooling Parts
Looking for the perfect Engine Cooling Part for your 2022 Ford E-350 Super Duty? You’re in the right place. Below, you’ll find links to various types of Engine Cooling Parts that fit your vehicle. At Advance Auto Parts, we offer only the highest quality OEM and aftermarket Engine Cooling Parts, ensuring durability and a precise fit for your Ford E-350 Super Duty. Whether you’re driving a 2022 model or another popular model year like
2012,
2013,
2014,
2015,
2016,
2017,
2018,
2019, and
2021, we’ve got you covered. Purchasing Engine Cooling Parts from Advance Auto Parts is a smart choice, giving you access to trusted brands and parts built to perform. Below, you’ll find links to various types of Engine Cooling Parts that fit your vehicle.
Essential 2022 Ford E-350 Super Duty Engine Cooling Parts
Carquest Premium – Standard Thermostat: 192 Degrees (Part No.14269)
from
$17.99
Carquest Premium Thermostats are manufactured with OEM quality materials and safety standards by an OE Supplier. This thermostat will meet and exceed the expectations of the OE thermostat to insure the best product for your cooling system. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant. Offset design, air relief valve, and OEM style seals included where applicable.
Product Features:
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Product Features:
- High grade stainless steel and copper construction
- Meets or exceeds OEM standards
- Consistent and precise response to cooling system needs
- Original equipment design for worry-free direct fit replacement
- 100% tested and calibrated
Motorcraft – ORIGINAL EQUIPMENT THERMOSTAT (Part No.RT-1169)
from
$45.99
ORIGINAL EQUIPMENT THERMOSTAT
Carquest Premium – Standard Thermostat: With Seal, 192 Degrees (Part No.1121-192)
from
$62.99
Carquest Premium Thermostats are manufactured with OEM quality materials and safety standards by an OE Supplier. This thermostat will meet and exceed the expectations of the OE thermostat to insure the best product for your cooling system. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant. Offset design, air relief valve, and OEM style seals included where applicable.
Product Features:
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Product Features:
- High grade stainless steel and copper construction
- Meets or exceeds OEM standards
- Consistent and precise response to cooling system needs
- Original equipment design for worry-free direct fit replacement
- 100% tested and calibrated
Carquest Premium – Standard Thermostat: 195 Degrees (Part No.14989)
from
$16.99
Carquest Premium Thermostats are manufactured with OEM quality materials and safety standards by an OE Supplier. This thermostat will meet and exceed the expectations of the OE thermostat to insure the best product for your cooling system. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant. Offset design, air relief valve, and OEM style seals included where applicable.
Product Features:
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Product Features:
- High grade stainless steel and copper construction
- Meets or exceeds OEM standards
- Consistent and precise response to cooling system needs
- Original equipment design for worry-free direct fit replacement
- 100% tested and calibrated
Carquest Premium – Radiator: With Transmission Oil Cooler (Part No.431359)
from
$311.99
Carquest Premium radiators are designed and engineered for maximum performance, using the highest-grade materials to ensure all radiators meet or exceed original equipment (O.E.) fit, form and function. Carquest Premium radiators are built by manufacturers that meet IATF 16949 certified framework, an internationally recognized proof of quality in the automotive industry. Most modern vehicles use radiators with plastic tanks and our parts are engineered with integrated ribbing to prevent damage during thermal cycling. Carquest Premium radiators are also 100% tested to ensure a durable, leak-free cooling system repair.
Product Features:
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Product Features:
- Thermal tested under real-life temperature simulations
- High tensile strength aluminum for maximum crimp strength
- Plastic tanks are engineered with integrated ribbing for added strength to withstand cracks, bowing and distortion during thermal cycles
- Thermal expansion slots extend core life and reduce failure rates by allowing improved core expansion and contraction during systematic heat cycles
- Oil cooler designs meet or exceed OE standards, keeping the vehicle¿s engine and transmission performing at optimal conditions
- OEM grade, premium fittings for transmission or engine oil coolers (where applicable)
Carquest Premium – Radiator: With Transmission Oil Cooler (Part No.434080)
from
$416.99
Carquest Premium radiators are designed and engineered for maximum performance, using the highest-grade materials to ensure all radiators meet or exceed original equipment (O.E.) fit, form and function. Carquest Premium radiators are built by manufacturers that meet IATF 16949 certified framework, an internationally recognized proof of quality in the automotive industry. Most modern vehicles use radiators with plastic tanks and our parts are engineered with integrated ribbing to prevent damage during thermal cycling. Carquest Premium radiators are also 100% tested to ensure a durable, leak-free cooling system repair.
Product Features:
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Product Features:
- Thermal tested under real-life temperature simulations
- High tensile strength aluminum for maximum crimp strength
- Plastic tanks are engineered with integrated ribbing for added strength to withstand cracks, bowing and distortion during thermal cycles
- Thermal expansion slots extend core life and reduce failure rates by allowing improved core expansion and contraction during systematic heat cycles
- Oil cooler designs meet or exceed OE standards, keeping the vehicle¿s engine and transmission performing at optimal conditions
- OEM grade, premium fittings for transmission or engine oil coolers (where applicable)
Carquest Premium – Radiator: With Transmission Oil Cooler (Part No.434081)
from
$315.99
Carquest Premium radiators are designed and engineered for maximum performance, using the highest-grade materials to ensure all radiators meet or exceed original equipment (O.E.) fit, form and function. Carquest Premium radiators are built by manufacturers that meet IATF 16949 certified framework, an internationally recognized proof of quality in the automotive industry. Most modern vehicles use radiators with plastic tanks and our parts are engineered with integrated ribbing to prevent damage during thermal cycling. Carquest Premium radiators are also 100% tested to ensure a durable, leak-free cooling system repair.
Product Features:
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Product Features:
- Thermal tested under real-life temperature simulations
- High tensile strength aluminum for maximum crimp strength
- Plastic tanks are engineeredáwith integrated ribbingáfor addedástrength to withstand cracks, bowing and distortion during thermal cycles
- Thermal expansion slots extend core life and reduce failure rates by allowing improved core expansion and contraction during systematic heat cycles
KAI – Radiator (Part No.RAD13083)
from
$278.99
New Platinum Pro Radiator, 5.4 Liter V8 Engine With Automatic Transmission, From Production Date 12/04/07
Product Features:
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Product Features:
- 5.4 Liter V8 Engine With Automatic Transmission, From Production Date 12/04/07, Made Of Plastic and Aluminum
- Meets All Federal Motor Safety Standards
- No Drilling Needed For Installation
- No Modifications Needed For Installation
- Direct Fit Replacement For Your Vehicle
- Same Form Fit And Function As OE
- Radiator Cap Not Included
- Check Out The Large Selection Of Parts Available For Your Vehicle
Dorman – Help – Engine Coolant Reservoir Cap: Twist, Plastic, 1 Pack (Part No.54208)
from
$16.99
Cracked or lost the original engine coolant reservoir cap? Replace it seamlessly and effectively with this precisely engineered, direct replacement cap.
Product Features:
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Product Features:
- Direct replacement – this engine coolant reservoir cap directly replaces a cracked or lost original cap
- Application specific – made to match dimensions of reservoir cap on only certain vehicle years, makes and models
- Seamless fit – reverse-engineered from the original equipment to fit perfectly
- Excellent value – a quick, easy replacement that’s less expensive than going back to the dealership
Carquest Premium – Standard Reservoir Cap: 16 PSI (Part No.10238)
from
$10.99
Crafted to meet the exact specifications set by Original Equipment Manufacturers (OEM), these products are engineered for effortless installation and removal. Constructed from premium-grade components, incorporating proper relief and vacuum valves, they ensure optimal performance even in the most demanding automotive cooling systems. Rigorously quality-tested, these components provide exceptional, out-of-the-box performance and superior durability to meet or exceed the highest standards of today’s vehicles.
Product Features:
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Product Features:
- Maintains proper cooling system pressure
- Easy installation and removal
- 100% tested to ensure proper pressure and longevity
- Meets all OEM specifications
Motorcraft – THERMOSTAT O-RING (Part No.RG-571)
from
$2.99
THERMOSTAT O-RING
Felpro – Multi-Purpose O-Ring (Part No.35489)
from
$10.99
Fel-Pro gaskets are specifically designed for the repair environment to deliver a reliable seal on even the most troublesome applications. Designed for imperfect sealing surfaces and manufactured with proprietary materials, you can count on Fel-Pro for innovative sealing solutions for the real-world repair environment.
Product Features:
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Product Features:
- Meets or exceeds all original equipment specifications
- Application specific design
- Manufactured for the sealing repair environment
- Validated for fit, form, and function
- Quality that you can trust
Felpro – Engine Coolant Thermostat Housing Gasket (Part No.35702)
from
$4.79
Fel-Pro gaskets offer 100% vehicle sealing with application-specific materials to give you sealing solutions with the performance and durability professionals trust.
Product Features:
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Product Features:
- Meets or exceeds all original equipment specifications
- Application specific design to ensure a perfect fit
- Engineered and manufactured specifically for the repair environment
- Unsurpassed quality you can trust
- Validated for fit, form, and function
Felpro – Engine Coolant Thermostat Housing Gasket (Part No.35610-1)
from
$6.49
Fel-Pro gaskets are specifically designed for the repair environment to deliver a reliable seal on even the most troublesome applications. Designed for imperfect sealing surfaces and manufactured with proprietary materials, you can count on Fel-Pro for innovative sealing solutions for the real-world repair environment.
Product Features:
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Product Features:
- Meets or exceeds all original equipment specifications
- Application specific design to ensure a perfect fit
- Engineered and manufactured specifically for the repair environment
- Unsurpassed quality you can trust
- Validated for fit, form, and function
Motorcraft – Radiator Cap (Part No.RS-527)
from
$12.29
Radiator Cap
Popular 2022 Ford E-350 Super Duty Engine Cooling Parts Categories
Most Popular Coolant Reservoir Caps for 2022 Ford E-350 Super Duties
Enhance your 2022 Ford E-350 Super Duty with one of the 2 Coolant Reservoir Caps we have in stock, starting at just $10.99.
Dorman – Help – Engine Coolant Reservoir Cap: Twist, Plastic, 1 Pack (Part No.54208)
from
$16.99
Cracked or lost the original engine coolant reservoir cap? Replace it seamlessly and effectively with this precisely engineered, direct replacement cap.
Product Features:
See More
Product Features:
- Direct replacement – this engine coolant reservoir cap directly replaces a cracked or lost original cap
- Application specific – made to match dimensions of reservoir cap on only certain vehicle years, makes and models
- Seamless fit – reverse-engineered from the original equipment to fit perfectly
- Excellent value – a quick, easy replacement that’s less expensive than going back to the dealership
Carquest Premium – Standard Reservoir Cap: 16 PSI (Part No.10238)
from
$10.99
Crafted to meet the exact specifications set by Original Equipment Manufacturers (OEM), these products are engineered for effortless installation and removal. Constructed from premium-grade components, incorporating proper relief and vacuum valves, they ensure optimal performance even in the most demanding automotive cooling systems. Rigorously quality-tested, these components provide exceptional, out-of-the-box performance and superior durability to meet or exceed the highest standards of today’s vehicles.
Product Features:
See More
Product Features:
- Maintains proper cooling system pressure
- Easy installation and removal
- 100% tested to ensure proper pressure and longevity
- Meets all OEM specifications
Best-Selling 2022 Ford E-350 Super Duty Thermostat
Upgrade your E-350 Super Duty with our best-selling Thermostat.
Carquest Premium – Standard Thermostat: With Seal, 192 Degrees (Part No.1121-192)
from
$62.99
Carquest Premium Thermostats are manufactured with OEM quality materials and safety standards by an OE Supplier. This thermostat will meet and exceed the expectations of the OE thermostat to insure the best product for your cooling system. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant. Offset design, air relief valve, and OEM style seals included where applicable.
Product Features:
See More
Product Features:
- High grade stainless steel and copper construction
- Meets or exceeds OEM standards
- Consistent and precise response to cooling system needs
- Original equipment design for worry-free direct fit replacement
- 100% tested and calibrated
Top-Quality Radiators for 2022 Ford E-350 Super Duties
Choose a high-quality OEM or aftermarket Radiator for Ford E-350 Super Duties and enjoy top-notch performance from $449.99.
Carquest Premium – Radiator (Part No.4113917)
from
$449.99
Reach Radiators offer one of the largest product ranges in the aftermarket, covering more than 95% of the popular automotive and light truck applications. Reach Radiators meet or exceed original equipment specifications, ensuring that products fit and perform just as well or better than the original parts, providing you peace of mind.
Product Features:
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Product Features:
- We design and manufacture all our radiators to meet or even exceed Original Equipment specifications. We take pride in producing the most reliable replacement parts in the market.
- Thermal expansion cuts allow for longer life and reduced failure rates by allowing improved core expansion and contraction during normal heat cycles.
- Our B-Type tubes feature central reinforcement to provide greater tolerance to pressure. Stronger tube design means drastically reduced probability of tube failure.
- We use longer header tabs for increased pressure resistance. This reduces the potential for tank to header leaks.
- Our deep extrusion header provides a stronger tube to header joint which is more resistant to the effects of vibration and thermal tube expansion, virtually eliminating tube to header leaks.
- Our fin edges are folded for increased stability and heat disbursement properties.
- Our included “multi-fit” attachments allow one radiator to cover multiple vehicle applications without sacrificing OE fit. This results in wider vehicle coverage with substantially less inventory.
Our Top Pick for a 2022 Ford E-350 Super Duty Radiator Cap
Invest in a
durable Radiator Cap for your 2022 Ford, knowing you’re getting trusted brands and expert craftsmanship.
Motorcraft – Radiator Cap (Part No.RS-527)
from
$12.29
Radiator Cap
Our Top-Rated Thermostat and Water Outlet Gaskets for 2022 Ford E-350 Super Duties
Make a smart move for your 2022 Ford E-350 Super Duty with our Thermostat and Water Outlet Gasket for $10.99.
Felpro – Multi-Purpose O-Ring (Part No.35489)
from
$10.99
Fel-Pro gaskets are specifically designed for the repair environment to deliver a reliable seal on even the most troublesome applications. Designed for imperfect sealing surfaces and manufactured with proprietary materials, you can count on Fel-Pro for innovative sealing solutions for the real-world repair environment.
Product Features:
See More
Product Features:
- Meets or exceeds all original equipment specifications
- Application specific design
- Manufactured for the sealing repair environment
- Validated for fit, form, and function
- Quality that you can trust
Top-Rated Engine Cooling Part Brands For Your 2022 Ford E-350 Super Duty
When it comes to finding the perfect Engine Cooling Part for your 2022 Ford E-350 Super Duty, Advance Auto Parts has you covered with a wide selection of high-quality OEM and aftermarket options from 4 trusted brands. We carry the most popular Engine Cooling Part brands including FELPRO, Carquest Premium, and Dorman, and more, all known for their exceptional customer ratings (average brand rating of 4.6 stars) and competitive prices, as low as $10.99. Purchasing a Engine Cooling Part from us here at Advance Auto Parts is a smart move for both you and your 2022 Ford E-350 Super Duty, providing peace of mind with parts that meet or exceed OEM standards.
Popular FELPRO 2022 Ford E-350 Super Duty Engine Cooling Parts
If you’re looking for a top-quality Engine Cooling Part for your 2022 Ford E-350 Super Duty, Advance Auto Parts has exactly what you need with our selection of FELPRO Engine Cooling Parts. We have 1 FELPRO Engine Cooling Parts in stock for this fitment, all known for their durability and precision fit. With prices starting at just $10.99, you’ll find the perfect Engine Cooling Part for your needs and budget. FELPRO Engine Cooling Parts for the 2022 Ford E-350 Super Duty come highly rated, with over 110 customer reviews and an impressive average rating of 4.6 stars. Choosing a FELPRO Engine Cooling Part from Advance Auto Parts is a smart move to ensure quality and value for your vehicle.
Top-Quality Carquest Premium 2022 Ford E-350 Super Duty Engine Cooling Parts
For those in search of a high-quality Engine Cooling Part for their 2022 Ford E-350 Super Duty, Advance Auto Parts offers a great selection of Carquest Premium Engine Cooling Parts. With 1 Carquest Premium Engine Cooling Parts in stock, you can trust you’re getting top-tier parts designed for durability and a perfect fit. Prices for these Engine Cooling Parts start at just $10.99, giving you a range of options to suit your budget. Backed by over 26 customer ratings and an average rating of 4.4 stars, Carquest Premium Engine Cooling Parts provide both reliability and excellent performance. Choosing a Carquest Premium Engine Cooling Part from Advance Auto Parts is a smart investment in your vehicle’s performance and longevity.
FAQs for 2022 Ford E-350 Super Duty Engine Cooling Parts
What are the best-selling Engine Cooling Parts for 2022 Ford E-350 Super Duties?
Out of 7 Engine Cooling Parts that fit 2022 Ford E-350 Super Duties, the following parts are the top sellers:
- Standard Reservoir Cap: 16 PSI (17110025) – $10.99
- Radiator Cap (50154701) – $12.29
- Standard Thermostat: With Seal, 192 Degrees (50042428) – $62.99
What’s the price range for 2022 Ford E-350 Super Duty Engine Cooling Parts?
The prices of Engine Cooling Parts for the 2022 Ford E-350 Super Duty range from $2.99 up to $449.99 for the most premium parts.
What is the average price of an Engine Cooling Part for a 2022 Ford E-350 Super Duty?
The average price for Engine Cooling Parts for the 2022 Ford E-350 Super Duty is $81.03. Keep in mind the variety of part types within our Engine Cooling Part category, where you are likely to find a wide range of prices across a variety of parts and components.
Does Advance Auto Parts sell Engine Cooling Parts for other Ford E-350 Super Duty model years?
What are the cheapest Engine Cooling Parts for my 2022 Ford E-350 Super Duty?
The cheapest 2022 Ford E-350 Super Duty Engine Cooling Parts we carry are:
- THERMOSTAT O-RING (50213631) – $2.99
- Multi-Purpose O-Ring (5180902) – $10.99
- Standard Reservoir Cap: 16 PSI (17110025) – $10.99
- Radiator Cap (50154701) – $12.29
- Engine Coolant Reservoir Cap: Twist, Plastic, 1 Pack (11153252) – $16.99
Does Advance Auto Parts sell Engine Cooling Parts for any other 2022 Ford models?
Yes. We stock Engine Cooling Parts for 23 other popular 2022 Ford models. Some of the most popular are 2022 F-150 Engine Cooling Parts, 2022 Mustang Engine Cooling Parts, 2022 Explorer Engine Cooling Parts, 2022 Bronco Engine Cooling Parts, and 2022 F-250 Super Duty Engine Cooling Parts.
What are the top-rated Engine Cooling Parts that fit the 2022 Ford E-350 Super Duty?
The one 2022 Ford E-350 Super Duty Engine Cooling Part we have in stock is the THERMOSTAT O-RING. It costs $2.99.
What types of Engine Cooling Parts do you sell for my 2022 Ford E-350 Super Duty?
As of 11/2/25, these are some of the most in-demand types of Engine Cooling Parts for a 2022 Ford E-350 Super Duty:
Can I get help with 2022 Ford E-350 Super Duty Engine Cooling Part orders?
Contact our customer support team by chat or phone, through the help desk page, where you can find instant answers about Ford Engine Cooling Parts and more.
What is your return policy for Ford E-350 Super Duty Engine Cooling Parts?
Advance Auto Parts keeps returns simple. For new Ford E-350 Super Duty Engine Cooling Parts and accessories, your online orders can be returned, in their original condition, within 45 days. For requirements, see the returns page.