2021 Lexus RX350 Drivetrains

Please Select your Vehicle to See Exact Fit Parts

Essential Drivetrains for 2021 Lexus RX350s

Dorman – Dorman Spindle Nut M22-1.50 Hex Star Pattern (Sold by each), 615-224 (Part No.615-224)

Dorman Spindle Nut M22-1.50 Hex Star Pattern (Sold by each), 615-224

from

$11.99
This spindle nut is designed to match the fit and function of the original part on specified vehicles. Made of quality materials, it is engineered for reliable performance.
See More

Valvoline – Valvoline Extended Protection Full Synthetic Automatic Transmission Fluid ATF 1 QT, 904976 (Part No.904976)

Valvoline Extended Protection Full Synthetic Automatic Transmission Fluid ATF 1 QT, 904976

from

$15.99
Modern transmissions are better than ever, with more gears to help improve fuel efficiency and acceleration. Greater performance calls for greater protection. Valvoline Extended Protection Full Synthetic ATF features our exclusive Dual Defense Additive Technology for two layers of protection against metal-on-metal contact and thermal breakdown, all while minimizing wear on clutch components. In fact, Valvoline Extended Protection Full Synthetic ATF is 45% stronger against breakdown compared to major brand DEX/MERC oxidative PDSC performance. Proven to maximize transmission life, our patented formula keeps your modern vehicle shifting smoothly, mile after mile, with the ultimate protection you can only expect from Valvoline, the #1 ATF brand.
See More

Valvoline – Valvoline Multi-Vehicle (ATF) Full Synthetic Automatic Transmission Fluid 1 GA, 904891 (Part No.904891)

Valvoline Multi-Vehicle (ATF) Full Synthetic Automatic Transmission Fluid 1 GA, 904891

from

$35.99
Choosing an automatic transmission fluid just got easier. Valvoline Full Synthetic MaxLife Multi-Vehicle ATF, the #1 ATF product, is suitable for use in 95% of ATF vehicles in operation with US registered light duty applications. And now, it€™s also recommended for most belt and chain-driven continuously variable transmissions (CVT). Featuring advanced additives to prevent the major causes of transmission breakdown, it€™s designed to help prevent leaks, reduce wear and tear, and maximize performance €“ all for much longer than conventional fluids. It has improved thermal stability for longer fluid life, better viscosity stability for consistent transmission operation, and frictional enhancements for smooth gear engagements. Whether your vehicle has a CVT or traditional automatic, Valvoline MaxLife Multi-Vehicle ATF is suitable for a broad range of transmissions including Ford, GM, Toyota, Honda, Nissan, Hyundai, Subaru, BMW, Mercedes, Volvo, VW and Audi vehicles. It€™s specifically recommended for use in the following applications: GM DEXRON-II, DEXRON-III, DEXRON-VI, and DEX-CVT; Ford MERCON LV; Toyota/Lexus Type T, T-II, T-IV, WS, CVTF FE, and CVTF TC. For the many miles ahead, trust your transmission with Valvoline, the #1 automatic transmission fluid brand.
See More

Carquest Premium – Carquest CV Axle Shaft Assembly, NCV905671 (Part No.NCV905671)

Carquest CV Axle Shaft Assembly, NCV905671

from

$114.99
Carquest Premium constant velocity (C.V.) axle shaft assemblies are 100% new units that are designed to meet or exceed OE specifications. Every part number is tested to guarantee a proper fit and reliable performance. Carquest Premium CV axles are assembled with a specially formulated high-temperature moly grease to resist friction and wear of the bearings and joints. Our strict engineering and quality specifications ensure a long-lasting repair that is guaranteed with an industry-leading warranty.
See More

Carquest Premium – Carquest New CV Axle Shaft Assembly, NCV69500 (Part No.NCV69500)

Carquest New CV Axle Shaft Assembly, NCV69500

from

$126.99
Carquest Premium constant velocity (C.V.) axle shaft assemblies are 100% new units that are designed to meet or exceed OE specifications. Every part number is tested to guarantee a proper fit and reliable performance. Carquest Premium CV axles are assembled with a specially formulated high-temperature moly grease to resist friction and wear of the bearings and joints. Our strict engineering and quality specifications ensure a long-lasting repair that is guaranteed with an industry-leading warranty.
See More

Carquest Premium – Carquest C/V Axle, NCV901911 (Part No.NCV901911)

Carquest C/V Axle, NCV901911

from

$151.99
Carquest C/V Axle, NCV901911. DRIVELINE – SHAFTS>SHAFTS & BOOT KITS>SHAFTS>CV SHAFTS – NEW from Carquest Premium
See More

Carquest Premium – Carquest New CV Axle Shaft Assembly, NCV329863 (Part No.NCV329863)

Carquest New CV Axle Shaft Assembly, NCV329863

from

$131.99
Carquest Premium constant velocity (C.V.) axle shaft assemblies are 100% new units that are designed to meet or exceed OE specifications. Every part number is tested to guarantee a proper fit and reliable performance. Carquest Premium CV axles are assembled with a specially formulated high-temperature moly grease to resist friction and wear of the bearings and joints. Our strict engineering and quality specifications ensure a long-lasting repair that is guaranteed with an industry-leading warranty.
See More

Carquest Premium – Carquest New CV Axle Assembly, NCV518618 (Part No.NCV518618)

Carquest New CV Axle Assembly, NCV518618

from

$106.99
Manufactured to be an OE replacement, CV axles use 100% new materials and are engineered for ease of installation and long service.
See More

Carquest Premium – Carquest CV Axle Shaft Assembly, NCV69582 (Part No.NCV69582)

Carquest CV Axle Shaft Assembly, NCV69582

from

$131.99
Carquest Premium constant velocity (C.V.) axle shaft assemblies are 100% new units that are designed to meet or exceed OE specifications. Every part number is tested to guarantee a proper fit and reliable performance. Carquest Premium CV axles are assembled with a specially formulated high-temperature moly grease to resist friction and wear of the bearings and joints. Our strict engineering and quality specifications ensure a long-lasting repair that is guaranteed with an industry-leading warranty.
See More

Carquest Premium – Carquest CV Axle Shaft Assembly, NCV69569 (Part No.NCV69569)

Carquest CV Axle Shaft Assembly, NCV69569

from

$119.99
Carquest Premium constant velocity (C.V.) axle shaft assemblies are 100% new units that are designed to meet or exceed OE specifications. Every part number is tested to guarantee a proper fit and reliable performance. Carquest Premium CV axles are assembled with a specially formulated high-temperature moly grease to resist friction and wear of the bearings and joints. Our strict engineering and quality specifications ensure a long-lasting repair that is guaranteed with an industry-leading warranty.
See More

Carquest Premium – Carquest CV Axle Shaft Assembly, NCV519483 (Part No.NCV519483)

Carquest CV Axle Shaft Assembly, NCV519483

from

$196.99
Carquest Premium constant velocity (C.V.) axle shaft assemblies are 100% new units that are designed to meet or exceed OE specifications. Every part number is tested to guarantee a proper fit and reliable performance. Carquest Premium CV axles are assembled with a specially formulated high-temperature moly grease to resist friction and wear of the bearings and joints. Our strict engineering and quality specifications ensure a long-lasting repair that is guaranteed with an industry-leading warranty.
See More

Carquest Premium – Carquest CV Axle Shaft Assembly, NCV517433 (Part No.NCV517433)

Carquest CV Axle Shaft Assembly, NCV517433

from

$146.99
Carquest Premium constant velocity (C.V.) axle shaft assemblies are 100% new units that are designed to meet or exceed OE specifications. Every part number is tested to guarantee a proper fit and reliable performance. Carquest Premium CV axles are assembled with a specially formulated high-temperature moly grease to resist friction and wear of the bearings and joints. Our strict engineering and quality specifications ensure a long-lasting repair that is guaranteed with an industry-leading warranty.
See More

Carquest Premium – Carquest CV Axle Shaft Assembly, NCV69535 (Part No.NCV69535)

Carquest CV Axle Shaft Assembly, NCV69535

from

$115.99
Carquest CV Axle Shaft Assembly, NCV69535. N
See More

Carquest Premium – Carquest CV Axle Assembly, NCV69108 (Part No.NCV69108)

Carquest CV Axle Assembly, NCV69108

from

$127.99
Carquest Premium constant velocity (C.V.) axle shaft assemblies are 100% new units that are designed to meet or exceed OE specifications. Every part number is tested to guarantee a proper fit and reliable performance. Carquest Premium CV axles are assembled with a specially formulated high-temperature moly grease to resist friction and wear of the bearings and joints. Our strict engineering and quality specifications ensure a long-lasting repair that is guaranteed with an industry-leading warranty.
See More

Carquest Premium – Carquest CV Axle Assembly, NCV69109 (Part No.NCV69109)

Carquest CV Axle Assembly, NCV69109

from

$126.99
Carquest Premium constant velocity (C.V.) axle shaft assemblies are 100% new units that are designed to meet or exceed OE specifications. Every part number is tested to guarantee a proper fit and reliable performance. Carquest Premium CV axles are assembled with a specially formulated high-temperature moly grease to resist friction and wear of the bearings and joints. Our strict engineering and quality specifications ensure a long-lasting repair that is guaranteed with an industry-leading warranty.
See More

Carquest Premium – Carquest New CV Axle Shaft Assembly, NCV69527 (Part No.NCV69527)

Carquest New CV Axle Shaft Assembly, NCV69527

from

$124.99
Carquest Premium constant velocity (C.V.) axle shaft assemblies are 100% new units that are designed to meet or exceed OE specifications. Every part number is tested to guarantee a proper fit and reliable performance. Carquest Premium CV axles are assembled with a specially formulated high-temperature moly grease to resist friction and wear of the bearings and joints. Our strict engineering and quality specifications ensure a long-lasting repair that is guaranteed with an industry-leading warranty.
See More

Carquest Premium – Carquest CV Axle Assembly, NCV69086 (Part No.NCV69086)

Carquest CV Axle Assembly, NCV69086

from

$183.99
Carquest Premium constant velocity (C.V.) axle shaft assemblies are 100% new units that are designed to meet or exceed OE specifications. Every part number is tested to guarantee a proper fit and reliable performance. Carquest Premium CV axles are assembled with a specially formulated high-temperature moly grease to resist friction and wear of the bearings and joints. Our strict engineering and quality specifications ensure a long-lasting repair that is guaranteed with an industry-leading warranty.
See More

Upgrade your 2021 Lexus RX350 with Top-Quality Drivetrains

When it comes to maintaining or upgrading your 2021 Lexus RX350, nothing is more important than using high-quality OEM or aftermarket parts that you can trust. Whether you’re repairing damage to your Lexus or enhancing its overall performance, Drivetrains are key to keeping your RX350 functioning at its best. At Advance Auto Parts, we offer a wide selection of 7 Drivetrains for the 2021 Lexus RX350, designed to meet your needs without breaking the bank. From Spindle replacements to Drive Shafts and Axles upgrades, we’ve got you covered with parts that fit your vehicle perfectly and ensure long-lasting performance.

Affordable Prices and Wide Selection

Shopping for Drivetrains for any vehicle can be a hassle, especially if you’re on a budget. But with Advance Auto Parts, you can find high-quality Drivetrains for your 2021 Lexus RX350 at great prices. Our Drivetrains inventory for this model ranges from just $11.99 to $196.99, with an average price of $99.99. Our 7 Drivetrains in stock come from 3 trusted brands, so you’re sure to find the right part for your 2021 Lexus RX350 without overspending.

Explore Related Parts and More

While you’re here, don’t forget to check out other essential categories that go hand in hand with Drivetrain upgrades. Explore related part types like Batteries and Chargers, Oil and Lubricants and more to make sure your 2021 Lexus RX350 is always ready to roll. We’re committed to providing you with everything you need to keep your RX350 in top shape, all in one place. Start shopping confidently below for your 2021 Lexus RX350!

Best-Selling Spindles for 2021 Lexus RX350s

Enhance the driving experience in your Lexus with 1 quality Spindle components, starting at $11.99.

Dorman – Dorman Spindle Nut M22-1.50 Hex Star Pattern (Sold by each), 615-224 (Part No.615-224)

Dorman Spindle Nut M22-1.50 Hex Star Pattern (Sold by each), 615-224

from

$11.99
This spindle nut is designed to match the fit and function of the original part on specified vehicles. Made of quality materials, it is engineered for reliable performance.
See More

Most Popular 2021 Lexus RX350 Drive Shafts and Axles

Customize your Lexus with 4 Drive Shafts and Axles products like Drive Shaft and Axles, all priced under $196.99.

Carquest Premium – Carquest CV Axle Shaft Assembly, NCV519483 (Part No.NCV519483)

Carquest CV Axle Shaft Assembly, NCV519483

from

$196.99
Carquest Premium constant velocity (C.V.) axle shaft assemblies are 100% new units that are designed to meet or exceed OE specifications. Every part number is tested to guarantee a proper fit and reliable performance. Carquest Premium CV axles are assembled with a specially formulated high-temperature moly grease to resist friction and wear of the bearings and joints. Our strict engineering and quality specifications ensure a long-lasting repair that is guaranteed with an industry-leading warranty.
See More

Carquest Premium – Carquest CV Axle Assembly, NCV69086 (Part No.NCV69086)

Carquest CV Axle Assembly, NCV69086

from

$183.99
Carquest Premium constant velocity (C.V.) axle shaft assemblies are 100% new units that are designed to meet or exceed OE specifications. Every part number is tested to guarantee a proper fit and reliable performance. Carquest Premium CV axles are assembled with a specially formulated high-temperature moly grease to resist friction and wear of the bearings and joints. Our strict engineering and quality specifications ensure a long-lasting repair that is guaranteed with an industry-leading warranty.
See More

Carquest Premium – Carquest CV Axle Assembly, NCV69108 (Part No.NCV69108)

Carquest CV Axle Assembly, NCV69108

from

$127.99
Carquest Premium constant velocity (C.V.) axle shaft assemblies are 100% new units that are designed to meet or exceed OE specifications. Every part number is tested to guarantee a proper fit and reliable performance. Carquest Premium CV axles are assembled with a specially formulated high-temperature moly grease to resist friction and wear of the bearings and joints. Our strict engineering and quality specifications ensure a long-lasting repair that is guaranteed with an industry-leading warranty.
See More

Carquest Premium – Carquest CV Axle Assembly, NCV69109 (Part No.NCV69109)

Carquest CV Axle Assembly, NCV69109

from

$126.99
Carquest Premium constant velocity (C.V.) axle shaft assemblies are 100% new units that are designed to meet or exceed OE specifications. Every part number is tested to guarantee a proper fit and reliable performance. Carquest Premium CV axles are assembled with a specially formulated high-temperature moly grease to resist friction and wear of the bearings and joints. Our strict engineering and quality specifications ensure a long-lasting repair that is guaranteed with an industry-leading warranty.
See More

Top Picks for 2021 Lexus RX350 Differentials

Upgrade Lexus RX350s with top-quality Differentials parts, including 2 OEM and aftermarket selections for your 2021 model.

Valvoline – Valvoline Multi-Vehicle (ATF) Full Synthetic Automatic Transmission Fluid 1 GA, 904891 (Part No.904891)

Valvoline Multi-Vehicle (ATF) Full Synthetic Automatic Transmission Fluid 1 GA, 904891

from

$35.99
Choosing an automatic transmission fluid just got easier. Valvoline Full Synthetic MaxLife Multi-Vehicle ATF, the #1 ATF product, is suitable for use in 95% of ATF vehicles in operation with US registered light duty applications. And now, it€™s also recommended for most belt and chain-driven continuously variable transmissions (CVT). Featuring advanced additives to prevent the major causes of transmission breakdown, it€™s designed to help prevent leaks, reduce wear and tear, and maximize performance €“ all for much longer than conventional fluids. It has improved thermal stability for longer fluid life, better viscosity stability for consistent transmission operation, and frictional enhancements for smooth gear engagements. Whether your vehicle has a CVT or traditional automatic, Valvoline MaxLife Multi-Vehicle ATF is suitable for a broad range of transmissions including Ford, GM, Toyota, Honda, Nissan, Hyundai, Subaru, BMW, Mercedes, Volvo, VW and Audi vehicles. It€™s specifically recommended for use in the following applications: GM DEXRON-II, DEXRON-III, DEXRON-VI, and DEX-CVT; Ford MERCON LV; Toyota/Lexus Type T, T-II, T-IV, WS, CVTF FE, and CVTF TC. For the many miles ahead, trust your transmission with Valvoline, the #1 automatic transmission fluid brand.
See More

Valvoline – Valvoline Extended Protection Full Synthetic Automatic Transmission Fluid ATF 1 QT, 904976 (Part No.904976)

Valvoline Extended Protection Full Synthetic Automatic Transmission Fluid ATF 1 QT, 904976

from

$15.99
Modern transmissions are better than ever, with more gears to help improve fuel efficiency and acceleration. Greater performance calls for greater protection. Valvoline Extended Protection Full Synthetic ATF features our exclusive Dual Defense Additive Technology for two layers of protection against metal-on-metal contact and thermal breakdown, all while minimizing wear on clutch components. In fact, Valvoline Extended Protection Full Synthetic ATF is 45% stronger against breakdown compared to major brand DEX/MERC oxidative PDSC performance. Proven to maximize transmission life, our patented formula keeps your modern vehicle shifting smoothly, mile after mile, with the ultimate protection you can only expect from Valvoline, the #1 ATF brand.
See More

FAQs for 2021 Lexus RX350 Drivetrains

Which Drivetrains are best-sellers for 2021 Lexus RX350s?

Out of 7 Drivetrains that fit 2021 Lexus RX350s, the following parts are the top sellers:

What’s the price range for 2021 Lexus RX350 Drivetrains?

Drivetrain prices for the 2021 Lexus RX350 start at $11.99 and go up to $196.99 for the most premium parts.

What’s the average price of a Drivetrain for a 2021 Lexus RX350?

The average price for Drivetrains for the 2021 Lexus RX350 is $99.99. Keep in mind the variety of part types within our Drivetrain category so you are likely to find a wide range of prices across a variety of parts and components.

Does Advance Auto Parts sell Drivetrains for other Lexus RX350 model years?

Yes, we currently carry Drivetrains for 18 model years of Lexus RX350s between 2007 and 2026. Drivetrains are bought most frequently for the following model years: 2022, 2020, 2019, 2018, 2017, 2016, 2015, 2014, and 2013.

What are the cheapest Drivetrains for my 2021 Lexus RX350?

What types of Drivetrains do you sell for my 2021 Lexus RX350?

As of 8/2/26, these are some of the most in-demand types of Drivetrains for a 2021 Lexus RX350:

Can I get help with 2021 Lexus RX350 Drivetrain orders?

Contact our customer support team, by chat or phone, through the help desk page, where you can find instant answers about Lexus Drivetrains and more.

What is your return policy for Lexus RX350 Drivetrains?

Advance Auto Parts keeps returns simple. For new Lexus RX350 Drivetrains and accessories, your online orders can be returned, in their original condition, within 45 days. For requirements, see the returns page.