2021 Lexus RX350 Engine Cooling Parts

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Keep Your 2021 Lexus RX350 in Top Shape with Quality Engine Cooling Parts

Whether you’re repairing or upgrading your Engine Cooling Part, using high-quality parts is key to keeping your 2021 Lexus RX350 looking sharp and performing at its best. At Advance Auto Parts we carry a wide selection of dependable options, including Thermostat and Water Outlet Gaskets, Coolant Temperature Sensors, and Radiators. Whether you’re replacing a damaged part or enhancing your truck’s style and protection, you’ll find exactly what you need to get the job done right.

Top-Rated Engine Cooling Parts from Trusted Brands

Looking for a reliable Engine Cooling Part? We’ve got you covered with options from brands you know and trust like Felpro and Carquest Premium. For example, Felpro Engine Cooling Parts start at just $6.49 with an average 4.6 star rating. Carquest Premium offer similar pricing and quality, backed by strong customer feedback. With over 434 reviews and a solid 4.4 star average, you can shop with confidence knowing other Lexus RX350 owners approve.

Competitive Prices and Extensive Inventory

The average price for a 2021 Lexus RX350 Engine Cooling Part at Advance Auto Parts is around $75.38, with a range that starts at $6.49 and goes up to $288.99. With 14 options in stock from 5 trusted brands, finding the right fit is easy. Popular picks like Carquest Multi-Purpose Relay, RAA1733, Motorad Integrated Thermostat Housing: With Sensor, With Seal, 188 Degrees, 1049-188, and Dorman Thermostat Assembly: Includes Housing and Thermostat, 189 Degrees, 902-5216 start at just $25.99 and offer a great balance of form and function.

Explore Related Parts

While you’re upgrading or replacing your Engine Cooling Part, don’t forget to check out other key components like Air Conditioning Parts and Blower Motor and Related Products. At Advance Auto Parts, we’re here to help you keep your 2021 Lexus RX350 in peak condition, inside and out.

Essential 2021 Lexus RX350 Engine Cooling Parts

DENSO – DENSO Relay, 567-0005 (Part No.567-0005)

DENSO Relay, 567-0005

from

$16.49
Relay IGNITION/EMISSION – ELECTRICAL COMPONENTS>SWITCHES & RELAYS>RELAYS>RELAYS from DENSO
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Carquest Premium – Carquest Multi-Purpose Relay, RAA1733 (Part No.RAA1733)

Carquest Multi-Purpose Relay, RAA1733

from

$25.99
Relays are electrical switches used to convert a small electrical load into a circuit capable of handling a high amperage load. Computers and small switches are not designed to carry the higher amperage requirement of a circuit that may have an electric motor, solenoid, or high amperage lighting fixture. Within a relay are contacts that are controlled with electromagnetism, when the circuit switch commands the device on or off, magnetism will pull or release the contact arm closing or opening the contacts within the relay that carry the voltage.
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Factory Air – Factory Air Coolant Temp Sensor Switch, 36424 (Part No.36424)

Factory Air Coolant Temp Sensor Switch, 36424

from

$34.05
High quality OE replacement part with all components needed to complete the job
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Carquest Premium – Carquest Engine Coolant Temperature Sensor, WTA2332 (Part No.WTA2332)

Carquest Engine Coolant Temperature Sensor, WTA2332

from

$96.99
Carquest Premium coolant temperature sensors and switches are designed to perform in harsh engine environments and meet or exceed original equipment (O.E.) specifications. Built by manufacturers that meet IATF 16949 certified framework, an internationally recognized proof of quality in the automotive industry, Carquest Premium coolant temperature sensors and switches undergo extensive validation testing to ensure long-lasting performance and reliability. Carquest Premium coolant temperature sensors and switches are part of our Carquest Vehicle Solutions, which is a full line of engine management and electronics products that help control ignition, fuel delivery and emission systems. Carquest Vehicle Solutions are OE-quality parts designed, engineered and tested by world-class manufacturers to ensure a reliable and long-lasting repair.
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Felpro – Felpro Engine Coolant Thermostat Seal, 35445 (Part No.35445)

Felpro Engine Coolant Thermostat Seal, 35445

from

$6.99
Fel-Pro gaskets are specifically designed for the repair environment to deliver a reliable seal on even the most troublesome applications. Designed for imperfect sealing surfaces and manufactured with proprietary materials, you can count on Fel-Pro for innovative sealing solutions for the real-world repair environment.
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Carquest Premium – Carquest Radiator Cap Tester Adapter, 12021 (Part No.12021)

Carquest Radiator Cap Tester Adapter, 12021

from

$18.99
Tester adapter for the MT-300 cooling system pressure testers. Professional grade test equipment to ensure an automotive cooling system is operating at the correct pressure. Made from high quality materials to ensure durability. Designed to test automotive coolant caps.
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Carquest Premium – Carquest Radiator Cap Tester Adapter, 12024 (Part No.12024)

Carquest Radiator Cap Tester Adapter, 12024

from

$17.99
Tester adapter for the MT-300 cooling system pressure testers. Professional grade test equipment to ensure an automotive cooling system is operating at the correct pressure. Made from high quality materials to ensure durability. Designed to test automotive coolant caps.
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Motorad – Motorad Integrated Thermostat Housing: With Sensor, With Seal, 188 Degrees, 1049-188 (Part No.1049-188)

Motorad Integrated Thermostat Housing: With Sensor, With Seal, 188 Degrees, 1049-188

from

$199.99
Manufactured with OEM quality materials and safety standards by an OE Supplier. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant.
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Dorman – Dorman Thermostat Assembly: Includes Housing and Thermostat, 189 Degrees, 902-5216 (Part No.902-5216)

Dorman Thermostat Assembly: Includes Housing and Thermostat, 189 Degrees, 902-5216

from

$147.99
This replacement engine coolant thermostat housing is engineered to match the fit and durability of the stock thermostat housing on specified vehicles. It is designed to withstand extreme temperature changes to extend service life.
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Victor Reinz – Victor Reinz Engine Coolant Thermostat Gasket, 71-12150-00 (Part No.71-12150-00)

Victor Reinz Engine Coolant Thermostat Gasket, 71-12150-00

from

$6.99
With Victor Reinz gaskets, you can be sure you are getting sealing solutions that deliver OE quality gasket technology and engineering. That is because Victor Reinz is an original equipment supplier and the trusted choice of manufacturers the world over, offering broad coverage for foreign and domestic cars and trucks. In Victor Reinz gasket sets, you get the right combination of components needed for fast, long-lasting repairs.
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Felpro – Felpro Engine Coolant Outlet Gasket, 35801 (Part No.35801)

Felpro Engine Coolant Outlet Gasket, 35801

from

$4.99
Fel-Pro gaskets offer 100% vehicle sealing with application-specific materials to give you sealing solutions with the performance and durability professionals trust.
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Carquest Premium – Carquest Cooling System Tester Adapter, 12025 (Part No.12025)

Carquest Cooling System Tester Adapter, 12025

from

$98.99
Tester adapter for the MT-300 cooling system pressure testers. Professional grade test equipment to ensure an automotive cooling system is operating at the correct pressure. Made from high quality materials to ensure durability. Designed to test automotive cooling systems.
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Carquest Premium – Carquest Fuel Cap Tester Adapter:, 12427 (Part No.12427)

Carquest Fuel Cap Tester Adapter:, 12427

from

$34.99
Fuel Cap Tester Adaper for use with Stant fuel cap testers. Color coded for easy identification. Made of durable plastic.
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Carquest Premium – Carquest Cooling System Tester Adapter, 12027 (Part No.12027)

Carquest Cooling System Tester Adapter, 12027

from

$31.99
Tester adapter for the MT-300 cooling system pressure testers. Professional grade test equipment to ensure an automotive cooling system is operating at the correct pressure. Made from high quality materials to ensure durability. Designed to test automotive cooling systems.
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Carquest Premium – Carquest Radiator Cap: 16 PSI, 10242 (Part No.10242)

Carquest Radiator Cap: 16 PSI, 10242

from

$16.99
Crafted to meet the exact specifications set by Original Equipment Manufacturers (OEM), these products are engineered for effortless installation and removal. Constructed from premium-grade components, incorporating proper relief and vacuum valves, they ensure optimal performance even in the most demanding automotive cooling systems. Rigorously quality-tested, these components provide exceptional, out-of-the-box performance and superior durability to meet or exceed the highest standards of today’s vehicles.
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Carquest Premium – Carquest Radiator Cap: 16 PSI, 10233 (Part No.10233)

Carquest Radiator Cap: 16 PSI, 10233

from

$14.99
Crafted to meet the exact specifications set by Original Equipment Manufacturers (OEM), these products are engineered for effortless installation and removal. Constructed from premium-grade components, incorporating proper relief and vacuum valves, they ensure optimal performance even in the most demanding automotive cooling systems. Rigorously quality-tested, these components provide exceptional, out-of-the-box performance and superior durability to meet or exceed the highest standards of today’s vehicles.
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Carquest Premium – Carquest Radiator Cap: 16 PSI, 10333 (Part No.10333)

Carquest Radiator Cap: 16 PSI, 10333

from

$21.99
Crafted to meet the exact specifications set by Original Equipment Manufacturers (OEM), these products are engineered for effortless installation and removal. Constructed from premium-grade components, incorporating proper relief and vacuum valves, they ensure optimal performance even in the most demanding automotive cooling systems. Rigorously quality-tested, these components provide exceptional, out-of-the-box performance and superior durability to meet or exceed the highest standards of today’s vehicles.
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Carquest Premium – Carquest Standard Reservoir Cap, T136 (Part No.T136)

Carquest Standard Reservoir Cap, T136

from

$37.49
Crafted to meet the exact specifications set by Original Equipment Manufacturers (OEM), these products are engineered for effortless installation and removal. Constructed from premium-grade components, incorporating proper relief and vacuum valves, they ensure optimal performance even in the most demanding automotive cooling systems. Rigorously quality-tested, these components provide exceptional, out-of-the-box performance and superior durability to meet or exceed the highest standards of today’s vehicles.
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Carquest Premium – Carquest Engine Coolant Reservoir Cap, T127 (Part No.T127)

Carquest Engine Coolant Reservoir Cap, T127

from

$11.99
Crafted to meet the exact specifications set by Original Equipment Manufacturers (OEM), these products are engineered for effortless installation and removal. Constructed from premium-grade components, incorporating proper relief and vacuum valves, they ensure optimal performance even in the most demanding automotive cooling systems. Rigorously quality-tested, these components provide exceptional, out-of-the-box performance and superior durability to meet or exceed the highest standards of today’s vehicles.
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Carquest Premium – Carquest Standard Reservoir Cap:, T118 (Part No.T118)

Carquest Standard Reservoir Cap:, T118

from

$6.99
Crafted to meet the exact specifications set by Original Equipment Manufacturers (OEM), these products are engineered for effortless installation and removal. Constructed from premium-grade components, incorporating proper relief and vacuum valves, they ensure optimal performance even in the most demanding automotive cooling systems. Rigorously quality-tested, these components provide exceptional, out-of-the-box performance and superior durability to meet or exceed the highest standards of today’s vehicles.
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Carquest Premium – Carquest Outlet Flange: With Gasket, CH2093 (Part No.CH2093)

Carquest Outlet Flange: With Gasket, CH2093

from

$74.99
Manufactured with OEM quality materials and safety standards by an OE Supplier. This housing will meet and exceed the expectations of the OE thermostat to insure the best product for your cooling system. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. The construction of this housing is improved over the OE design to fix and update any issues that the OE design may have had.
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Carquest Premium – Carquest Radiator: With Transmission Oil Cooler, 813116 (Part No.813116)

Carquest Radiator: With Transmission Oil Cooler, 813116

from

$247.99
A global leader in the manufacture and distribution of aftermarket cooling products for automotive, heavy truck, and industrial applications. Specialized in the production of OE-quality Radiators, Condensers, and Charge Air Coolers for US and international markets, covering over 10,000 part numbers worldwide. Reach Cooling is headquartered in Miami, Florida, with additional distribution centers in Los Angeles, California and a manufacturing plant in Shanghai, China.
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KAI – KAI Radiator, RAD13019 (Part No.RAD13019)

KAI Radiator, RAD13019

from

$148.99
New Platinum Pro Radiator, 3.5 Liter V6 Engine With Automatic Transmission
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KAI – KAI Radiator, RAD13116 (Part No.RAD13116)

KAI Radiator, RAD13116

from

$142.99
New Platinum Pro Radiator, 3.5 Liter Engine With Automatic Transmission, Without Tow Package, With A/C, USA/Japan Built Models
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Carquest Premium – Carquest Radiator, 813019 (Part No.813019)

Carquest Radiator, 813019

from

$416.99
A global leader in the manufacture and distribution of aftermarket cooling products for automotive, heavy truck, and industrial applications. Specialized in the production of OE-quality Radiators, Condensers, and Charge Air Coolers for US and international markets, covering over 10,000 part numbers worldwide. Reach Cooling is headquartered in Miami, Florida, with additional distribution centers in Los Angeles, California and a manufacturing plant in Shanghai, China.
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Carquest Premium – Carquest Radiator, 813596 (Part No.813596)

Carquest Radiator, 813596

from

$288.99
Reach Radiators offer one of the largest product ranges in the aftermarket, covering more than 95% of the popular automotive and light truck applications. Reach Radiators meet or exceed original equipment specifications, ensuring that products fit and perform just as well or better than the original parts, providing you peace of mind.
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Carquest Premium – Carquest Radiator: With Transmission Oil Cooler, 813207 (Part No.813207)

Carquest Radiator: With Transmission Oil Cooler, 813207

from

$320.99
A global leader in the manufacture and distribution of aftermarket cooling products for automotive, heavy truck, and industrial applications. Specialized in the production of OE-quality Radiators, Condensers, and Charge Air Coolers for US and international markets, covering over 10,000 part numbers worldwide. Reach Cooling is headquartered in Miami, Florida, with additional distribution centers in Los Angeles, California and a manufacturing plant in Shanghai, China.
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Most Popular Thermostat and Water Outlet Gaskets for 2021 Lexus RX350s

Enhance your 2021 Lexus RX350 with one of the 2 Thermostat and Water Outlet Gaskets we have in stock, starting at just $6.49.

Felpro – Felpro Engine Coolant Thermostat Housing Gasket, 35809 (Part No.35809)

Felpro Engine Coolant Thermostat Housing Gasket, 35809

from

$6.49
Fel-Pro gaskets are specifically designed for the repair environment to deliver a reliable seal on even the most troublesome applications. Designed for imperfect sealing surfaces and manufactured with proprietary materials, you can count on Fel-Pro for innovative sealing solutions for the real-world repair environment.
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Victor Reinz – Victor Reinz Engine Coolant Thermostat Gasket, 71-12150-00 (Part No.71-12150-00)

Victor Reinz Engine Coolant Thermostat Gasket, 71-12150-00

from

$6.99
With Victor Reinz gaskets, you can be sure you are getting sealing solutions that deliver OE quality gasket technology and engineering. That is because Victor Reinz is an original equipment supplier and the trusted choice of manufacturers the world over, offering broad coverage for foreign and domestic cars and trucks. In Victor Reinz gasket sets, you get the right combination of components needed for fast, long-lasting repairs.
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Best-Selling 2021 Lexus RX350 Coolant Temperature Sensor

Upgrade your RX350 with our best-selling Coolant Temperature Sensor.

Carquest Premium – Carquest Coolant Temperature Sensor 1TS1172, WTC2071 (Part No.WTC2071)

Carquest Coolant Temperature Sensor 1TS1172, WTC2071

from

$65.99
Carquest Premium coolant temperature sensors and switches are designed to perform in harsh engine environments and meet or exceed original equipment (O.E.) specifications. Built by manufacturers that meet IATF 16949 certified framework, an internationally recognized proof of quality in the automotive industry, Carquest Premium coolant temperature sensors and switches undergo extensive validation testing to ensure long-lasting performance and reliability. Carquest Premium coolant temperature sensors and switches are part of our Carquest Vehicle Solutions, which is a full line of engine management and electronics products that help control ignition, fuel delivery and emission systems. Carquest Vehicle Solutions are OE-quality parts designed, engineered and tested by world-class manufacturers to ensure a reliable and long-lasting repair.
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Top-Quality Radiators for 2021 Lexus RX350s

Choose a high-quality OEM or aftermarket Radiator for Lexus RX350s and enjoy top-notch performance from $288.99.

Carquest Premium – Carquest Radiator, 813596 (Part No.813596)

Carquest Radiator, 813596

from

$288.99
Reach Radiators offer one of the largest product ranges in the aftermarket, covering more than 95% of the popular automotive and light truck applications. Reach Radiators meet or exceed original equipment specifications, ensuring that products fit and perform just as well or better than the original parts, providing you peace of mind.
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Our Top Pick for a 2021 Lexus RX350 Engine Coolant Thermostat Housing Cap

Invest in a durable Engine Coolant Thermostat Housing Cap for your 2021 Lexus, knowing you’re getting trusted brands and expert craftsmanship.

Carquest Premium – Carquest Radiator Cap: 16 PSI, 10242 (Part No.10242)

Carquest Radiator Cap: 16 PSI, 10242

from

$16.99
Crafted to meet the exact specifications set by Original Equipment Manufacturers (OEM), these products are engineered for effortless installation and removal. Constructed from premium-grade components, incorporating proper relief and vacuum valves, they ensure optimal performance even in the most demanding automotive cooling systems. Rigorously quality-tested, these components provide exceptional, out-of-the-box performance and superior durability to meet or exceed the highest standards of today’s vehicles.
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Our Coolant Reservoir Caps for 2021 Lexus RX350s

Make a smart move for your 2021 Lexus RX350 with our Coolant Reservoir Cap for $61.99.

Carquest Premium – Carquest Reservoir Cap, T162 (Part No.T162)

Carquest Reservoir Cap, T162

from

$61.99
Crafted to meet the exact specifications set by Original Equipment Manufacturers (OEM), these products are engineered for effortless installation and removal. Constructed from premium-grade components, incorporating proper relief and vacuum valves, they ensure optimal performance even in the most demanding automotive cooling systems. Rigorously quality-tested, these components provide exceptional, out-of-the-box performance and superior durability to meet or exceed the highest standards of today’s vehicles.
See More

Top-Rated Engine Cooling Part Brands For Your 2021 Lexus RX350

When it comes to finding the perfect Engine Cooling Part for your 2021 Lexus RX350, Advance Auto Parts has you covered with a wide selection of high-quality OEM and aftermarket options from 5 trusted brands. We carry the most popular Engine Cooling Part brands including Felpro and Carquest Premium, and more, all known for their exceptional customer ratings (average brand rating of 4.6 stars) and competitive prices, as low as $6.49. Purchasing a Engine Cooling Part from us here at Advance Auto Parts is a smart move for both you and your 2021 Lexus RX350, providing peace of mind with parts that meet or exceed OEM standards.

Popular Felpro 2021 Lexus RX350 Engine Cooling Parts

If you’re looking for a top-quality Engine Cooling Part for your 2021 Lexus RX350, Advance Auto Parts has exactly what you need with our selection of Felpro Engine Cooling Parts. We have 2 Felpro Engine Cooling Parts in stock for this fitment, all known for their durability and precision fit. With prices starting at just $6.49 and an average cost of $6.74, you’ll find the perfect Engine Cooling Part for your needs and budget. Felpro Engine Cooling Parts for the 2021 Lexus RX350 come highly rated, with over 79 customer reviews and an impressive average rating of 4.6 stars. Choosing a Felpro Engine Cooling Part from Advance Auto Parts is a smart move to ensure quality and value for your vehicle.
Felpro Engine Coolant Thermostat Housing Gasket, 35809
from $6.49
(3)
Felpro Engine Coolant Thermostat Housing Gasket, 35809
“Fits perfectly fine”

Top-Quality Carquest Premium 2021 Lexus RX350 Engine Cooling Parts

For those in search of a high-quality Engine Cooling Part for their 2021 Lexus RX350, Advance Auto Parts offers a great selection of Carquest Premium Engine Cooling Parts. With 2 Carquest Premium Engine Cooling Parts in stock, you can trust you’re getting top-tier parts designed for durability and a perfect fit. Prices for these Engine Cooling Parts start at just $16.99, with an average price of $17.49, giving you a range of options to suit your budget. Backed by over 138 customer ratings and an average rating of 4.5 stars, Carquest Premium Engine Cooling Parts provide both reliability and excellent performance. Choosing a Carquest Premium Engine Cooling Part from Advance Auto Parts is a smart investment in your vehicle’s performance and longevity.
Carquest Radiator Cap Tester Adapter, 12024
from $17.99
(1)
Carquest Radiator Cap Tester Adapter, 12024
“Works well.”
Carquest Radiator Cap: 16 PSI, 10242
from $16.99
(137)
Carquest Radiator Cap: 16 PSI, 10242
“This product fixed the problem.”

FAQs for 2021 Lexus RX350 Engine Cooling Parts

What are the best-selling Engine Cooling Parts for 2021 Lexus RX350s?

Out of 14 Engine Cooling Parts that fit 2021 Lexus RX350s, the following parts are the top sellers:

What’s the price range for 2021 Lexus RX350 Engine Cooling Parts?

The prices of Engine Cooling Parts for the 2021 Lexus RX350 range from $6.49 up to $288.99 for the most premium parts.

What is the average price of an Engine Cooling Part for a 2021 Lexus RX350?

The average price for Engine Cooling Parts for the 2021 Lexus RX350 is $75.38. Keep in mind the variety of part types within our Engine Cooling Part category, where you are likely to find a wide range of prices across a variety of parts and components.

Does Advance Auto Parts sell Engine Cooling Parts for other Lexus RX350 model years?

Yes, we carry Engine Cooling Parts for 18 model years of Lexus RX350s between 2007 and 2026. The following model years are the most popular for Engine Cooling Part purchases: 2022, 2020, 2019, 2018, 2017, 2016, 2015, 2014, and 2013.

What are the cheapest Engine Cooling Parts for my 2021 Lexus RX350?

The cheapest 2021 Lexus RX350 Engine Cooling Parts we carry are:

Does Advance Auto Parts sell Engine Cooling Parts for any other 2021 Lexus models?

Yes. We stock Engine Cooling Parts for 11 other popular 2021 Lexus models. Some of the most popular are 2021 ES350 Engine Cooling Parts, 2021 GX460 Engine Cooling Parts, 2021 ES250 Engine Cooling Parts, 2021 IS300 Engine Cooling Parts, and 2021 IS350 Engine Cooling Parts.

What are the top-rated Engine Cooling Parts that fit the 2021 Lexus RX350?

Based on 434 reviews by customers, our 2021 Lexus RX350 Engine Cooling Parts have an average customer rating of 4.4 stars. These are the highest-rated categories of Engine Cooling Parts for the 2021 Lexus RX350 and their top-rated products:

What types of Engine Cooling Parts do you sell for my 2021 Lexus RX350?

As of 8/2/26, these are some of the most in-demand types of Engine Cooling Parts for a 2021 Lexus RX350:

Can I get help with 2021 Lexus RX350 Engine Cooling Part orders?

Contact our customer support team by chat or phone, through the help desk page, where you can find instant answers about Lexus Engine Cooling Parts and more.

What is your return policy for Lexus RX350 Engine Cooling Parts?

Advance Auto Parts keeps returns simple. For new Lexus RX350 Engine Cooling Parts and accessories, your online orders can be returned, in their original condition, within 45 days. For requirements, see the returns page.