2021 Lexus RX350 Cooling and Climate Controls

Essential Cooling and Climate Controls for 2021 Lexus RX350s

Carquest – A/C Compressor Clutch Relay (Part No.R3130)

A/C Compressor Clutch Relay

from

$40.99
Product Features:
  • Our units are all pre-aligned & pre-adjusted to save installation time and ensure proper switching.
  • A lubricated felt pad that lubricates the cam lobes on the vehicles distributor. This reduces wear on the point set rubbing block, extending the usable life of the part.
  • Ventilated where available, tungsten contacts, which run cooler and exhibit less erosion.
  • The copper-alloy shunt provides superior resistance to breakage, due to the flexing of the moving arm on the point set. It also significantly increases current conductivity over typical steel, shunts.
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Carquest Premium – Radiator Cap Tester Adapter (Part No.12024)

Radiator Cap Tester Adapter

from

$16.49
Tester adapter for the MT-300 cooling system pressure testers. Professional grade test equipment to ensure an automotive cooling system is operating at the correct pressure. Made from high quality materials to ensure durability. Designed to test automotive coolant caps.

Product Features:
  • Machined metal construction
  • Works with MT-300 pressure tester
  • Tests coolant caps
  • Professional quality
See More

Santech – Aux. Fan Control Uni (Part No.G5007755207SII)

Aux. Fan Control Uni

from

$199.49
Aux. Fan Control Uni

Stant – THERMOSTAT SEAL (Part No.27286)

THERMOSTAT SEAL

from

$1.49
THERMOSTAT SEAL

Koyo Cooling – Radiator (Part No.G1000337108KCS)

Radiator

from

$289.69
Plastic Tank / Aluminum Core Radiator Koyo radiators are available in plastic tank and aluminum core. The Nocolok brazing line keeps the highest quality standards, bringing you superior products you can rely on. The Koyo Cooling radiator has been engineered to the highest standards and incorporates application specific mounting locations for all fan shrouds, inlet-outlet hoses and top-bottom mounting pins, ensuring quick and pain-free installs.

Product Features:
  • All Aluminum Core and Plastic Tank
  • OE Style mounting brackets and hose connections
  • Integrated transmission oil cooler when applicable
  • Compact and lightweight
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Carquest Premium – Radiator: With Transmission Oil Cooler (Part No.813207)

Radiator: With Transmission Oil Cooler

from

$294.99
Carquest Premium radiators are designed and engineered for maximum performance, using the highest-grade materials to ensure all radiators meet or exceed original equipment (O.E.) fit, form and function. Carquest Premium radiators are built by manufacturers that meet IATF 16949 certified framework, an internationally recognized proof of quality in the automotive industry. Most modern vehicles use radiators with plastic tanks and our parts are engineered with integrated ribbing to prevent damage during thermal cycling. Carquest Premium radiators are also 100% tested to ensure a durable, leak-free cooling system repair.

Product Features:
  • Thermal tested under real-life temperature simulations
  • High tensile strength aluminum for maximum crimp strength
  • Plastic tanks are engineeredáwith integrated ribbingáfor addedástrength to withstand cracks, bowing and distortion during thermal cycles
  • Thermal expansion slots extend core life and reduce failure rates by allowing improved core expansion and contraction during systematic heat cycles
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Driveworks Water Pumps – Water Pump: New, Installation Gasket Included (Part No.57-1671)

Water Pump: New, Installation Gasket Included

from

$69.99
Driveworks Water Pumps offer a complete replacement part solution, with application coverage that spans from antique to present-day vehicles. All units are 100% tested and engineered to meet or exceed OEM performance, providing you a quality product you and your vehicle can rely on. All units are manufacturered with brand new components and are packaged with all gaskets required for replacement.

Product Features:
  • 100% Factory tested for leakage and dimensional precision
  • Manufactured to original casting specifications to ensure a proper fit and proper water flow for efficient cooling
  • Bearings made of heat-treated carbon or carburized steel are sealed and lubricated to ensure smooth performance throughout units life
  • Assembled with new, high-quality unitized shaft seals to prevent premature leakage
  • Supplied with gasket and other seals/gaskets as applicable per application to help complete the job
  • This pump is driven by the accessory belt and we recommend replacement if nearing service recommendation
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Carquest Premium – Engine Water Pump: New, Gasket/Seals Included (Part No.T3130)

Engine Water Pump: New, Gasket/Seals Included

from

$134.99
Carquest Premium drive motor inverter cooler water pumps are 100% new, high-quality parts that meet or exceed original equipment (O.E.) specifications. All components, including the housing, impeller, controller, gaskets, and seals are designed for long-lasting service life. These electric water pumps are supplied with the gaskets or seals necessary for installation. Our Carquest Premium auxiliary water pumps undergo stringent testing to ensure superior performance that we stand behind with an industry-leading warranty.

Product Features:
  • Built to meet or exceed OE fit, form and function
  • All components necessary for installation are supplied with pump
  • 100% tested for reliable performance
  • Follow all enclosed instructions to maximize pump life and validate warranty
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Dorman – Thermostat Assembly: Includes Housing and Thermostat, 189 Degrees (Part No.902-5216)

Thermostat Assembly: Includes Housing and Thermostat, 189 Degrees

from

$162.99
This replacement engine coolant thermostat housing assembly is engineered to match the fit and durability of the stock housing assembly on specified vehicles. It is designed to withstand extreme temperature changes to extend service life.

Product Features:
  • Ideal replacement – this engine coolant thermostat housing assembly directly replaces the original water outlet on specified vehicle years, makes and models.
  • Durable construction – this part is specifically designed to withstand extreme temperature changes and resist cracking and leaking.
  • Cost-effective and reliable – offers original manufacturer quality at lower cost than getting replacement at dealer
  • Industry-leading design – professionally engineered by the aftermarket leader in replacement thermostat housing assemblies
See More

Motorad – Integrated Thermostat Housing: With Sensor, With Seal, 188 Degrees (Part No.1049-188)

Integrated Thermostat Housing: With Sensor, With Seal, 188 Degrees

from

$229.99
Manufactured with OEM quality materials and safety standards by an OE Supplier. This integrated thermostat housing will meet and exceed the expectations of the OE thermostat to insure the best product for your cooling system. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant as well as the design and function of the housing. Offset design, air relief valve, and OEM style seals included where applicable.

Product Features:
  • High grade stainless steel and copper construction
  • Meets or exceeds OEM standards
  • Consistent and precise response to cooling system needs
  • Original equipment design for worry-free direct fit replacement
  • 100% tested and calibrated
See More

DENSO – New Compressor With Clutch (Part No.471-1017)

New Compressor With Clutch

from

$589.99
As one of the world’s largest OE suppliers of A/C compressors, DENSO units are specified by most major vehicle manufacturers. DENSO First Time Fit A/C compressors are manufactured and tested to the strictest OE standards for unparalleled performance. At DENSO, we bring together everything we know as an air conditioning systems manufacturer to bring you the highest quality line of factory-new compressors available. When it comes to new compressors, you can’t do better than going with a unit manufactured by the OE supplier. At DENSO we know these units better than anyone because we originally designed them. Our compressors are built to meet DENSO’s unsurpassed reputation for technological superiority. You can relax knowing DENSO will give you the right part and the right fit the first time.

Product Features:
  • DENSO is the world’s largest OE supplier of A/C compressors
  • Each compressor is precision manufactured for exact replacement
  • Designed for high output and extended durability
  • Highest quality in the Aftermarket
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DENSO – New Compressor With Clutch (Part No.471-1575)

New Compressor With Clutch

from

$552.99
As one of the world’s largest OE suppliers of A/C compressors, DENSO units are specified by most major vehicle manufacturers. DENSO First Time Fit A/C compressors are manufactured and tested to the strictest OE standards for unparalleled performance. At DENSO, we bring together everything we know as an air conditioning systems manufacturer to bring you the highest quality line of factory-new compressors available. When it comes to new compressors, you can’t do better than going with a unit manufactured by the OE supplier. At DENSO we know these units better than anyone because we originally designed them. Our compressors are built to meet DENSO’s unsurpassed reputation for technological superiority. You can relax knowing DENSO will give you the right part and the right fit the first time.

Product Features:
  • DENSO is the world’s largest OE supplier of A/C compressors
  • Each compressor is precision manufactured for exact replacement
  • Designed for high output and extended durability
  • Highest quality in the Aftermarket
See More

Felpro – Engine Coolant Outlet Gasket (Part No.35801)

Engine Coolant Outlet Gasket

from

$3.99
Fel-Pro gaskets offer 100% vehicle sealing with application-specific materials to give you sealing solutions with the performance and durability professionals trust

Product Features:
  • Meets or exceeds all original equipment specifications
  • Application specific design to ensure a perfect fit
  • Engineered and manufactured specifically for the repair environment
  • Unsurpassed quality you can trust
  • Validated for fit, form, and function
See More

Felpro – WATER OUTLET GASKET (Part No.35767)

WATER OUTLET GASKET

from

$2.29
Fel-Pro gaskets offer 100% vehicle sealing with application-specific materials to give you sealing solutions with the performance and durability professionals trust

Product Features:
  • Meets or exceeds all original equipment specifications
  • Application specific design
  • Manufactured for the sealing repair environment
  • Validated for fit, form, and function
  • Quality that you can trust
See More

Dorman – Radiator Filler Neck (Part No.G1011719777DOR)

Radiator Filler Neck

from

$61.95
Re-engineered to address common failure points in the original equipment, Dorman’s Engine Coolant Filler Neck has improved durability and resistance. It withstands the extreme changes in temperature that frequently cause housing to become brittle, crack and leak. This is more than a replacement; it’s an upgrade. Maintain the steady flow of coolant and lessen the chances of overheating.

Product Features:
  • Direct replacement for a proper fit every time
  • Quality tested to ensure a trouble-free installation and conformance to product standards
  • High-quality plastic or metal construction
  • Includes all hardware necessary for a complete repair (where applicable)
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Carquest Premium – OUTLET FLANGE (Part No.CH2093)

OUTLET FLANGE

from

$74.99
OUTLET FLANGE

Autopart International Inc – A/C Compressor (Part No.R10003200404API)

A/C Compressor

from

$414.16
A/C Compressor

Carquest Premium – New Compressor with Clutch, Nippondenso 7SAS17C (Part No.T168348)

New Compressor with Clutch, Nippondenso 7SAS17C

from

$465.99
High quality OE replacement part with all components needed to complete the job.

Product Features:
  • Endurance tested the equivalent of 50k miles
  • Includes specific electrical connector to eliminate splicing
  • Charged with lubricant to reduce internal friction promoting enhanced system performance and longevity
  • For ease of installation this compressor includes a direct fit OE style connector as well as all gaskets, O-rings, or seals needed to repair your car
  • Each unit is individually leak, vacuum and pressure tested prior to packaging to ensure leak free performance
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DENSO – Engine Coolant Temperature Sensor (Part No.193-1000)

Engine Coolant Temperature Sensor

from

$82.99
DENSO’s engine coolant temperatures sensors are manufactured to the strictest OE standards resulting in superior efficiency. OE quality with precise sensing elements. Exact fit which controls fuel injection ignition timing and transmission shifting.

Product Features:
  • OE technology adapted for the aftermarket
  • Reduces emissions, increased performance
  • Delivers the highest reliability and detection accuracy
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Carquest Premium – Coolant Temperature Sensor with O-Ring (Part No.WTC2071)

Coolant Temperature Sensor with O-Ring

from

$8.99
Approved materials for increased durability in even the most extreme temperatures. All MotoRad Coolant Temperature Sensors are designed to meet or exceed OEM specifications at our ISO TS16949 manufacturing facilities.

Product Features:
  • 100% factory resistance calibrated to ensure precision tolerances, resulting in extremely accurate temperature for optimal performance
  • Thread Sealant and/or O-ring pre-installed on applicable sensors to ensure leak free performance
  • Brass sensor housing precision machined to meet or exceed OE thermal conductivity
  • OE precision matched thermistor position for correct output parameters
  • Extensive product testing includes salt spray, high/low temperature impact, thermal vibration, durability, static electricity, and micro tension, among other tests, to ensure all sensors meet or exceed OEM specifications.
See More

Carquest Premium – Radiator Cap: 16 PSI (Part No.10242)

Radiator Cap: 16 PSI

from

$14.99
Crafted to meet the exact specifications set by Original Equipment Manufacturers (OEM), these products are engineered for effortless installation and removal. Constructed from premium-grade components, incorporating proper relief and vacuum valves, they ensure optimal performance even in the most demanding automotive cooling systems. Rigorously quality-tested, these components provide exceptional, out-of-the-box performance and superior durability to meet or exceed the highest standards of today’s vehicles.

Product Features:
  • Maintains proper cooling system pressure
  • Easy installation and removal
  • 100% tested to ensure proper pressure and longevity
  • Meets all OEM specifications
See More

Carquest Premium – Radiator Cap: 13 PSI (Part No.10241)

Radiator Cap: 13 PSI

from

$14.99
Crafted to meet the exact specifications set by Original Equipment Manufacturers (OEM), these products are engineered for effortless installation and removal. Constructed from premium-grade components, incorporating proper relief and vacuum valves, they ensure optimal performance even in the most demanding automotive cooling systems. Rigorously quality-tested, these components provide exceptional, out-of-the-box performance and superior durability to meet or exceed the highest standards of today’s vehicles.

Product Features:
  • Maintains proper cooling system pressure
  • Easy installation and removal
  • 100% tested to ensure proper pressure and longevity
  • Meets all OEM specifications
See More

Santech – Drier Desiccant Elem (Part No.R10432105970SII)

Drier Desiccant Elem

from

$20.54
Drier Desiccant Elem

KAI – A/C Desiccant Element (Part No.ARD010152)

A/C Desiccant Element

from

$10.99
New Standard Replacement A/C Receiver Drier/Desiccant Element

Product Features:
  • Meets All Federal Motor Safety Standards
  • No Drilling Needed For Installation
  • No Modifications Needed For Installation
  • Direct Fit Replacement For Your Vehicle
  • Same Form Fit And Function As OE
  • Check Out The Large Selection Of Parts Available For Your Vehicle
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Carquest Premium – Blower Motor: With Wheel (Part No.75076)

Blower Motor: With Wheel

from

$123.99
Carquest Premium Blower Motors are engineered and tested to provide years of trouble free operation. Backed by over 50 years of mobile A/C experience, fix it once and fix it right with Carquest Premium Blower Motors. Meets or exceeds OE design. Magnetic size and properties compare or exceed OEM. Windings meet or exceed OEM Specifications. Motor RPM equivalent to or exceeds OEM motor.

Product Features:
  • Meets or exceeds OE design and performance
  • Magnetic size and properties compare or exceed OEM
  • Windings meet or exceed OEM specifications
  • Motor RPM equivalent to or exceeds OEM motor
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Carquest Premium – Blower Motor: With Wheel (Part No.76513)

Blower Motor: With Wheel

from

$304.99
Carquest Premium Blower Motors are engineered and tested to provide years of trouble free operation. Backed by over 50 years of mobile A/C experience, fix it once and fix it right with Carquest Premium Blower Motors. Meets or exceeds OE design. Magnetic size and properties compare or exceed OEM. Windings meet or exceed OEM Specifications. Motor RPM equivalent to or exceeds OEM motor.

Product Features:
  • Meets or exceeds OE design and performance
  • Magnetic size and properties compare or exceed OEM
  • Windings meet or exceed OEM specifications
  • Motor RPM equivalent to or exceeds OEM motor
  • Functionally Equivalent to OE Design
  • Magnetic size and properties compare or exceed OEM
  • Hermetically Sealed & Thermally Protected Electronics
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Santech – A/C Pressure Switch (Part No.R1054261110SII)

A/C Pressure Switch

from

$44.70
A/C Pressure Switch

Carquest Premium – A/C Refrigerant Pressure Sensor (Part No.ACA1745)

A/C Refrigerant Pressure Sensor

from

$83.99
The Carquest Premium line of vehicle electronics are designed for OE form, fit and function for both import and domestic vehicles. The A/C Pressure Sensor reports system pressures to the on-board computer, in turn allowing the computer to properly and efficiently control the compressor, fans and system levels. An improperly functioning A/C Pressure Sensor will provide erratic or inaccurate readings to on-board computers severely affecting system performance and function. Without reliable and accurate data from a properly functioning A/C Pressure Sensor, on-board computers are unable to protect the safety of critical components and the system as a whole which can lead to excessive wear and tear on critical components and costly system damage.

Product Features:
  • Designed and manufactured with high quality materials, industry leading electronic components and strict quality controls. Engineered to exceed OE performance and to meet the uncompromising demands of service professionals.
  • Direct fit replacement matches proper OE fit, form, and function and ensures trouble free installation of your A/C Pressure Sensor.
  • All units are helium leak tested on fully automated mass spectrometer equipment before end-of-line testing.
  • All units are tested using automated end-of-line testing equipment that pressurizes the A/C Pressure Sensor and checks full-spectrum functionality and electrical output to ensure each A/C Pressure Sensor meets manufacturing specifications before packaging
See More

Upgrade your 2021 Lexus RX350 with Top-Quality Cooling and Climate Controls

When it comes to maintaining or upgrading your 2021 Lexus RX350, nothing is more important than using high-quality OEM or aftermarket parts that you can trust. Whether you’re repairing damage to your Lexus or enhancing its overall performance, Cooling and Climate Controls are key to keeping your RX350 functioning at its best. At Advance Auto Parts, we offer a wide selection of 21 Cooling and Climate Controls for the 2021 Lexus RX350, designed to meet your needs without breaking the bank. From Engine Cooling Part replacements to Air Conditioning Parts upgrades, we’ve got you covered with parts that fit your vehicle perfectly and ensure long-lasting performance.

Affordable Prices and Wide Selection

Shopping for Cooling and Climate Controls for any vehicle can be a hassle, especially if you’re on a budget. But with Advance Auto Parts, you can find high-quality Cooling and Climate Controls for your 2021 Lexus RX350 at great prices. Our Cooling and Climate Controls inventory for this model ranges from just $5.49 to $465.99, with an average price of $137.02. Our 21 Cooling and Climate Controls in stock come from 9 trusted brands, so you’re sure to find the right part for your 2021 Lexus RX350 without overspending.

Top Brands and High Customer Satisfaction

Advance Auto Parts takes pride in offering only the best brands in the automotive industry. For your 2021 Lexus RX350, we stock popular OEM and aftermarket Cooling and Climate Controls from top names like FELPRO Carquest Premium, and more. FELPRO Cooling and Climate Controls start at just $5.49 and boast an impressive 5 stars average rating from customers. With 436 customer reviews and counting, our 2021 Lexus RX350 Cooling and Climate Controls have a strong track record of reliability, ensuring you can trust your purchase.

Explore Related Parts and More

While you’re here, don’t forget to check out other essential categories that go hand in hand with Cooling and Climate Control upgrades. Explore related part types like Batteries and Chargers, Oil and Lubricants and more to make sure your 2021 Lexus RX350 is always ready to roll. We’re committed to providing you with everything you need to keep your RX350 in top shape, all in one place. Start shopping confidently below for your 2021 Lexus RX350!

Best-Selling Engine Cooling Parts for 2021 Lexus RX350s

Enhance the driving experience in your Lexus with 13 quality Engine Cooling Part components, starting at $5.49.

Felpro – Engine Coolant Thermostat Seal (Part No.35445)

Engine Coolant Thermostat Seal

from

$5.49
Fel-Pro gaskets offer 100% vehicle sealing with application-specific materials to give you sealing solutions with the performance and durability professionals trust

Product Features:
  • Meets or exceeds all original equipment specifications
  • Application specific design to ensure a perfect fit
  • Engineered and manufactured specifically for the repair environment
  • Unsurpassed quality you can trust
  • Validated for fit, form, and function
See More

Sankei Switches – Sankei Switches Radiator Cap (Part No.G101045813SAK)

Sankei Switches Radiator Cap

from

$11.27
The Sankei Switches radiator cap range has been developed to operate within original equipment manufacturer’s specifications. A faulty radiator cap can cause your car to boil-over at a lower temperature. Test or replace the coolant cap when servicing the cooling system.

Product Features:
  • Meets Original Equipment specifications.
  • Made from premium materials.
  • Designed to function on open cooling systems and overflow reservoir type systems.
See More

Felpro – Engine Coolant Thermostat Housing Gasket (Part No.35809)

Engine Coolant Thermostat Housing Gasket

from

$5.49
Fel-Pro gaskets offer 100% vehicle sealing with application-specific materials to give you sealing solutions with the performance and durability professionals trust

Product Features:
  • Meets or exceeds all original equipment specifications
  • Application specific design
  • Validated for fit, form, and function
  • Quality that you can trust
  • Each Fel-Pro gasket, no matter how small, is engineered to exacting standards with proprietary design, engineering and manufacturing processes
See More

Carquest Premium – Radiator Cap: 16 PSI (Part No.10242)

Radiator Cap: 16 PSI

from

$14.99
Crafted to meet the exact specifications set by Original Equipment Manufacturers (OEM), these products are engineered for effortless installation and removal. Constructed from premium-grade components, incorporating proper relief and vacuum valves, they ensure optimal performance even in the most demanding automotive cooling systems. Rigorously quality-tested, these components provide exceptional, out-of-the-box performance and superior durability to meet or exceed the highest standards of today’s vehicles.

Product Features:
  • Maintains proper cooling system pressure
  • Easy installation and removal
  • 100% tested to ensure proper pressure and longevity
  • Meets all OEM specifications
See More

Carquest Premium – Radiator Cap Tester Adapter (Part No.12024)

Radiator Cap Tester Adapter

from

$16.49
Tester adapter for the MT-300 cooling system pressure testers. Professional grade test equipment to ensure an automotive cooling system is operating at the correct pressure. Made from high quality materials to ensure durability. Designed to test automotive coolant caps.

Product Features:
  • Machined metal construction
  • Works with MT-300 pressure tester
  • Tests coolant caps
  • Professional quality
See More

DENSO – First Time Fit Relay (Part No.P2020194560ND)

First Time Fit Relay

from

$25.84
An electrical relay is sort of a magical device: it takes a small electrical signal and uses it to manage a much more powerful current, permitting electrical systems to be both lighter and more dependable at the same time. DENSO has supplied quality relays to the OE automotive world for over 60 years. The very same performance and dependability are available across the replacement aftermarket with DENSO First Time Fit® relays. Engineered to meet the most stringent automaker standards for shock resistance, arcing, and thermal protection, DENSO auto relays feature the lowest return rates in the industry; that equals value for car owners and repair facilities alike

Product Features:
  • Lead-free, solderless construction prevents heat shock and arcing
  • Controlled contact force, self-adjusting air gap increase longevity of the internal parts
  • Industry-standard packaging and footprint
  • Low heat generation
  • Reduced electrical loads
  • Built to last
See More

Motorad – Integrated Thermostat Housing: With Sensor, With Seal, 188 Degrees (Part No.1049-188)

Integrated Thermostat Housing: With Sensor, With Seal, 188 Degrees

from

$229.99
Manufactured with OEM quality materials and safety standards by an OE Supplier. This integrated thermostat housing will meet and exceed the expectations of the OE thermostat to insure the best product for your cooling system. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant as well as the design and function of the housing. Offset design, air relief valve, and OEM style seals included where applicable.

Product Features:
  • High grade stainless steel and copper construction
  • Meets or exceeds OEM standards
  • Consistent and precise response to cooling system needs
  • Original equipment design for worry-free direct fit replacement
  • 100% tested and calibrated
See More

Carquest Premium – Radiator: With Transmission Oil Cooler (Part No.813596)

Radiator: With Transmission Oil Cooler

from

$259.99
Carquest Premium radiators are designed and engineered for maximum performance, using the highest-grade materials to ensure all radiators meet or exceed original equipment (O.E.) fit, form and function. Carquest Premium radiators are built by manufacturers that meet IATF 16949 certified framework, an internationally recognized proof of quality in the automotive industry. Most modern vehicles use radiators with plastic tanks and our parts are engineered with integrated ribbing to prevent damage during thermal cycling. Carquest Premium radiators are also 100% tested to ensure a durable, leak-free cooling system repair.

Product Features:
  • Thermal tested under real-life temperature simulations
  • High tensile strength aluminum for maximum crimp strength
  • Plastic tanks are engineeredáwith integrated ribbingáfor addedástrength to withstand cracks, bowing and distortion during thermal cycles
  • Thermal expansion slots extend core life and reduce failure rates by allowing improved core expansion and contraction during systematic heat cycles
See More

Santech – Aux. Fan Control Uni (Part No.G5007755207SII)

Aux. Fan Control Uni

from

$199.49
Aux. Fan Control Uni

Dorman – Thermostat Assembly: Includes Housing and Thermostat, 189 Degrees (Part No.902-5216)

Thermostat Assembly: Includes Housing and Thermostat, 189 Degrees

from

$162.99
This replacement engine coolant thermostat housing assembly is engineered to match the fit and durability of the stock housing assembly on specified vehicles. It is designed to withstand extreme temperature changes to extend service life.

Product Features:
  • Ideal replacement – this engine coolant thermostat housing assembly directly replaces the original water outlet on specified vehicle years, makes and models.
  • Durable construction – this part is specifically designed to withstand extreme temperature changes and resist cracking and leaking.
  • Cost-effective and reliable – offers original manufacturer quality at lower cost than getting replacement at dealer
  • Industry-leading design – professionally engineered by the aftermarket leader in replacement thermostat housing assemblies
See More

Aisan – Water Pump (Part No.G3000838456ASC)

Water Pump

from

$134.77
Water Pump

Carquest Premium – OUTLET FLANGE (Part No.CH2093)

OUTLET FLANGE

from

$74.99
OUTLET FLANGE

Carquest Premium – Coolant Temperature Sensor with O-Ring (Part No.WTC2071)

Coolant Temperature Sensor with O-Ring

from

$8.99
Approved materials for increased durability in even the most extreme temperatures. All MotoRad Coolant Temperature Sensors are designed to meet or exceed OEM specifications at our ISO TS16949 manufacturing facilities.

Product Features:
  • 100% factory resistance calibrated to ensure precision tolerances, resulting in extremely accurate temperature for optimal performance
  • Thread Sealant and/or O-ring pre-installed on applicable sensors to ensure leak free performance
  • Brass sensor housing precision machined to meet or exceed OE thermal conductivity
  • OE precision matched thermistor position for correct output parameters
  • Extensive product testing includes salt spray, high/low temperature impact, thermal vibration, durability, static electricity, and micro tension, among other tests, to ensure all sensors meet or exceed OEM specifications.
See More

Most Popular 2021 Lexus RX350 Air Conditioning Parts

Customize your Lexus with 6 Air Conditioning Parts products like AC Compressor Without Clutch, AC Compressor With Clutch, and Accumulator and Receiver Driers, all priced under $465.99.

Carquest Premium – A/C Refrigerant Pressure Sensor (Part No.ACA1745)

A/C Refrigerant Pressure Sensor

from

$83.99
The Carquest Premium line of vehicle electronics are designed for OE form, fit and function for both import and domestic vehicles. The A/C Pressure Sensor reports system pressures to the on-board computer, in turn allowing the computer to properly and efficiently control the compressor, fans and system levels. An improperly functioning A/C Pressure Sensor will provide erratic or inaccurate readings to on-board computers severely affecting system performance and function. Without reliable and accurate data from a properly functioning A/C Pressure Sensor, on-board computers are unable to protect the safety of critical components and the system as a whole which can lead to excessive wear and tear on critical components and costly system damage.

Product Features:
  • Designed and manufactured with high quality materials, industry leading electronic components and strict quality controls. Engineered to exceed OE performance and to meet the uncompromising demands of service professionals.
  • Direct fit replacement matches proper OE fit, form, and function and ensures trouble free installation of your A/C Pressure Sensor.
  • All units are helium leak tested on fully automated mass spectrometer equipment before end-of-line testing.
  • All units are tested using automated end-of-line testing equipment that pressurizes the A/C Pressure Sensor and checks full-spectrum functionality and electrical output to ensure each A/C Pressure Sensor meets manufacturing specifications before packaging
See More

Carquest Premium – New Compressor with Clutch, Nippondenso 7SAS17C (Part No.T168348)

New Compressor with Clutch, Nippondenso 7SAS17C

from

$465.99
High quality OE replacement part with all components needed to complete the job.

Product Features:
  • Endurance tested the equivalent of 50k miles
  • Includes specific electrical connector to eliminate splicing
  • Charged with lubricant to reduce internal friction promoting enhanced system performance and longevity
  • For ease of installation this compressor includes a direct fit OE style connector as well as all gaskets, O-rings, or seals needed to repair your car
  • Each unit is individually leak, vacuum and pressure tested prior to packaging to ensure leak free performance
See More

Carquest Premium – New Compressor (Part No.T168367)

New Compressor

from

$462.99
Carquest Premium A/C compressors are 100% new units that are manufactured to the highest quality to meet or exceed OE specifications.

Product Features:
  • Every unit is 100% function and leak tested
  • Tested for noise, vibration, durability, vacuum decay and pressure decay to ensure no leaks and longer life
  • Very low friction coating used on swash plate to improve durability
  • PTFE coated pistons improve performance and reduce wear
  • Rubber dampened clutch plate ensures smooth clutch engagement and reduces wear
  • Matched high-quality needle-roller bearing ensures low friction and high load capability
  • Limited Lifetime Warranty when following warranty requirements: Flush A/C System, replace accumulator/receiver dryer, replace orifice tube/expansion device, and filling with correct oil and refrigerant
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Carquest Standard – Reman Nippondenso 7SAS17C Compressor w/ Clutch (Part No.DW167348)

Reman Nippondenso 7SAS17C Compressor w/ Clutch

from

$219.99
Our products are engineered and tested to provide years of trouble free operation. Backed by over 50 years of mobile a/c experience, fix it once and fix it right with Carquest.

Product Features:
  • Remanufactured compressors are 100 percent tested to ensure compressor function and noise level meets or exceeds OE specifications
  • Remanufactured compressors come pre-charged with 3 ounces of PAG oil for R134a or R1234yf applications
  • Remanufactured compressors are individually vacuum and pressure tested to ensure no leaks
  • Remanufactured compressors come with the R12/R134A/1234yf required O-rings /sealing washers to install the compressor
  • Remanufactured Compressors are built in a ISO9001:2015 Certified facility to ensure consistent quality standards in the Re-manufacturing process
  • Remanufactured compressors are 100 percent tested to ensure compressor function and noise level meets or exceeds OE specifications
  • Remanufactured compressors come pre-charged with 3 ounces of PAG oil for R134a or R1234yf applications
  • Remanufactured compressors are individually vacuum and pressure tested to ensure no leaks
  • Remanufactured compressors come with the R12/R134A/1234yf required O-rings /sealing washers to install the compressor
  • Remanufactured Compressors are built in a ISO9001:2015 Certified facility to ensure consistent quality standards in the Re-manufacturing process
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Santech – A/C Pressure Switch (Part No.R1054261110SII)

A/C Pressure Switch

from

$44.70
A/C Pressure Switch

Carquest Premium – A/C Desiccant Bag Kit (Part No.T83233)

A/C Desiccant Bag Kit

from

$19.99
Carquest Accumulators and Receiver Driers are designed to store, filter and dry the air conditioning refrigerant to provide proper performance and durability for the air conditioning system. They are manufactured to meet or exceed original equipment specifications.

Product Features:
  • All parts meet or exceed original equipment standards for moisture absorption, pressure and temperature resistance, air tightness, vibration resistance, corrosiveness, and pulse pressure.
  • Desiccant is 100% tested and assembled in a controlled environment to ensure performance meets or exceeds original equipment standards.
  • All accumulators and receiver driers are helium leak tested prior to packaging.
  • O-Rings necessary for installation are included.
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Top Picks for 2021 Lexus RX350 Blower Motor and Related Products

Upgrade Lexus RX350s with top-quality Blower Motor and Related Products parts, including 2 OEM and aftermarket selections for your 2021 model.

Carquest Premium – Blower Motor: With Wheel (Part No.76513)

Blower Motor: With Wheel

from

$304.99
Carquest Premium Blower Motors are engineered and tested to provide years of trouble free operation. Backed by over 50 years of mobile A/C experience, fix it once and fix it right with Carquest Premium Blower Motors. Meets or exceeds OE design. Magnetic size and properties compare or exceed OEM. Windings meet or exceed OEM Specifications. Motor RPM equivalent to or exceeds OEM motor.

Product Features:
  • Meets or exceeds OE design and performance
  • Magnetic size and properties compare or exceed OEM
  • Windings meet or exceed OEM specifications
  • Motor RPM equivalent to or exceeds OEM motor
  • Functionally Equivalent to OE Design
  • Magnetic size and properties compare or exceed OEM
  • Hermetically Sealed & Thermally Protected Electronics
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Carquest Premium – Blower Motor: With Wheel (Part No.75076)

Blower Motor: With Wheel

from

$123.99
Carquest Premium Blower Motors are engineered and tested to provide years of trouble free operation. Backed by over 50 years of mobile A/C experience, fix it once and fix it right with Carquest Premium Blower Motors. Meets or exceeds OE design. Magnetic size and properties compare or exceed OEM. Windings meet or exceed OEM Specifications. Motor RPM equivalent to or exceeds OEM motor.

Product Features:
  • Meets or exceeds OE design and performance
  • Magnetic size and properties compare or exceed OEM
  • Windings meet or exceed OEM specifications
  • Motor RPM equivalent to or exceeds OEM motor
See More

Top-Rated Cooling and Climate Controls Brands For Your 2021 Lexus RX350

Shop for the best-rated brands offering Cooling and Climate Controls and other products for your 2021 Lexus RX350s. Below you’ll find some of our best rated Cooling and Climate Controls from FELPRO and Carquest Premium, and more. Cooling and Climate Controls from these brands that fit a 2021 RX350 start at just $5.49 and are rated as high as 5 stars. OEM and aftermarket Cooling and Climate Controls don’t get more top quality, durable, and affordable than from the brands below.

Popular FELPRO 2021 Lexus RX350 Cooling and Climate Controls

When it comes to maintaining or upgrading your 2021 Lexus RX350, using quality Cooling and Climate Controls is essential to ensure durability and a perfect fit. FELPRO ticks all of those boxes. We offer a wide selection of FELPRO Cooling and Climate Controls, specifically designed for the 2021 Lexus RX350. With over 2 FELPRO brand Cooling and Climate Controls in stock, you’re sure to find what you need. The prices for these top-notch parts start as low as $5.49. Plus, with over 79 customer reviews and an average rating of 5 stars, you can trust that our FELPRO Cooling and Climate Controls will get the job done right. Choose Advance Auto Parts for reliability, quality, and expert-approved parts that keep your vehicle running strong.

Engine Coolant Thermostat Seal
from
$5.49

(76)

Engine Coolant Thermostat Seal

“quality product.”

Engine Coolant Thermostat Housing Gasket
from
$5.49

(3)

Engine Coolant Thermostat Housing Gasket

“Just what I needed”

Popular Carquest Premium 2021 Lexus RX350 Cooling and Climate Controls

Carquest Premium auto parts is one of the highest quality Cooling and Climate Control brands in the market. Any 2021 Lexus RX350 owner should feel confident when installing genuine Carquest Premium parts in their vehicle. To ensure the best fit and performance for your 2021 RX350, Advance Auto Parts carries a full inventory of 11 Carquest Premium Cooling and Climate Controls. Plus you will be keeping your Lexus in peak condition while saving money because prices on these Carquest Premium Cooling and Climate Controls range from $8.99 to $465.99, plus, with more than 138 customer reviews and an impressive 4 stars average rating, you can be confident the Fram Cooling and Climate Controls below will deliver on both quality and value.

New Compressor with Clutch, Nippondenso 7SAS17C
from
$465.99
This product is not rated

New Compressor with Clutch, Nippondenso 7SAS17C

“”

A/C Refrigerant Pressure Sensor
from
$83.99
This product is not rated

A/C Refrigerant Pressure Sensor

“”

New Compressor
from
$462.99
This product is not rated

New Compressor

“”

FAQs for 2021 Lexus RX350 Cooling and Climate Controls

Which Cooling and Climate Controls are best-sellers for 2021 Lexus RX350s?

Out of 21 Cooling and Climate Controls that fit 2021 Lexus RX350s, the following parts are the top sellers:

What’s the price range for 2021 Lexus RX350 Cooling and Climate Controls?

Cooling and Climate Control prices for the 2021 Lexus RX350 start at $5.49 and go up to $465.99 for the most premium parts.

What’s the average price of a Cooling and Climate Control for a 2021 Lexus RX350?

The average price for Cooling and Climate Controls for the 2021 Lexus RX350 is $137.02. Keep in mind the variety of part types within our Cooling and Climate Control category so you are likely to find a wide range of prices across a variety of parts and components.

Does Advance Auto Parts sell Cooling and Climate Controls for other Lexus RX350 model years?

Yes, we currently carry Cooling and Climate Controls for 17 model years of Lexus RX350s between 2007 and 2024. Cooling and Climate Controls are bought most frequently for the following model years: 2022, 2020, 2019, 2018, 2017, 2016, 2015, 2014, and 2013.

What are the cheapest Cooling and Climate Controls for my 2021 Lexus RX350?

The cheapest 2021 Lexus RX350 Cooling and Climate Controls we carry in stock are:

What are the top-rated Cooling and Climate Controls that fit the 2021 Lexus RX350?

Out of 436 reviews by customers, our 2021 Lexus RX350 Cooling and Climate Controls have an average customer rating of . These are some of the highest-rated Cooling and Climate Control types for the 2021 Lexus RX350 and their top-rated products:

What types of Cooling and Climate Controls do you sell for my 2021 Lexus RX350?

Can I get help with 2021 Lexus RX350 Cooling and Climate Control orders?

Contact our customer support team, by chat or phone, through the help desk page, where you can find instant answers about Lexus Cooling and Climate Controls and more.

What is your return policy for Lexus RX350 Cooling and Climate Controls?

Advance Auto Parts keeps returns simple. For new Lexus RX350 Cooling and Climate Controls and accessories, your online orders can be returned, in their original condition, within 45 days. For requirements, see the returns page.