2021 Ford E-350 Super Duty Drive Shafts and Axles

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Keep Your 2021 Ford E-350 Super Duty in Top Shape with Quality Drive Shafts and Axles

Whether you’re repairing or upgrading your Drive Shafts and Axle, using high-quality parts is key to keeping your 2021 Ford E-350 Super Duty looking sharp and performing at its best. At Advance Auto Parts we carry a wide selection of dependable options, including Axle Shaft Universal Joints, Axle Flange Gaskets, and Drive Shaft Support Bolts. Whether you’re replacing a damaged part or enhancing your truck’s style and protection, you’ll find exactly what you need to get the job done right.

Top-Rated Drive Shafts and Axles from Trusted Brands

Looking for a reliable Drive Shafts and Axle? We’ve got you covered with options from brands you know and trust like Spicer and Dorman. For example, Spicer Drive Shafts and Axles start at just $45.99 with an average 4.6 star rating. Dorman offer similar pricing and quality, backed by strong customer feedback. With over 24 reviews and a solid 5 star average, you can shop with confidence knowing other Ford E-350 Super Duty owners approve.

Explore Related Parts

While you’re upgrading or replacing your Drive Shafts and Axle, don’t forget to check out other key components like Differentials and Universal Joints. At Advance Auto Parts, we’re here to help you keep your 2021 Ford E-350 Super Duty in peak condition, inside and out.

Essential 2021 Ford E-350 Super Duty Drive Shafts and Axles

Dorman – BEAM AXLE (Part No.526-022)

BEAM AXLE

from

$249.99
BEAM AXLE

Dorman – Axle Flange Gasket Kit (Part No.926-880)

Axle Flange Gasket Kit

from

$27.99
Ensure a leak-free repair when servicing axle bearings or parking brake shoes. This axle shaft flange seal is a direct replacement for the original gasket and should be replaced every time work is performed at the axle flange.

Product Features:


    Product Features:
    • Ideal replacement – this axle shaft flange seal directly replaces the original gasket without having to visit the dealer
    • Required for routine service – this gasket should be replaced every time work is performed at the axle flange
    • Durable construction – this axle shaft flange gasket is made of tough, durable materials for leak-free performance
    • Quality tested – this flange gasket has been designed and tested for a guaranteed fit
See More

Anchor – Center Support Bearing Motor Mount: Center, 1 Piece (Part No.6053)

Center Support Bearing Motor Mount: Center, 1 Piece

from

$38.99
Anchor 6053 Center support bearings support a driveshaft between transmission and differential. This mount relieves stress on driveline components. Each part is engineered and designed to OE Standards. Natural and SBR rubber provide maximum life and performance. Steel fasteners are heat treated grade 5 bolts. A special bonding agent is used to ensure a rubber to metal bond. Rubber material is mixed to specific Durometer, hardness.

Product Features:
  • MAXIMUM VIBRATION DAMPENING: Rubber cushion is made of high grade rubber that ensures maximum dampening of vibration and the ability to absorb over loads.
  • HEAVY GAUGE STEEL FRAME: The housing frame is made from heavy gauge steel with durability that extends the service life.
  • READY TO INSTALL: Most center supports include a sealed bearing and dust shield and are ready to install.
  • For Years: 1960-2015
  • Weight approx: 3 Lbs
  • BEARING ID / BORE: 1.5750 In. / 40 mm
  • CENTERLINE: 2.28 In. / 58 mm
  • Mount Width: 6.62 In. / 168 mm
  • No Studs
See More

Dorman – CNTR SUPPORT BEARING (Part No.934-007)

CNTR SUPPORT BEARING

from

$83.99
CNTR SUPPORT BEARING

Spicer – Drive Shaft Center Support Bearing (Part No.211359X)

Drive Shaft Center Support Bearing

from

$83.99
The part you need. The name you trust. Spicer driveline components deliver top performance and value. These center bearing kits are manufactured to the same genuine standards you’ve come to expect from the most reliable name in driveshaft parts.

Product Features:
  • Dana manufactured Spicer center bearing kit
  • Interchangeable with OE component
  • Comes as a complete kit to replace, repair, or refurbish
  • Latest production upgrades ensure genuine Spicer parts are as good or better than the OE parts they replace
See More

Anchor – Center Support Bearing Motor Mount: Center, 1 Piece (Part No.6038)

Center Support Bearing Motor Mount: Center, 1 Piece

from

$40.99
Anchor 6038 Center support bearings support a driveshaft between transmission and differential. This mount relieves stress on driveline components. Each part is engineered and designed to OE Standards. Natural and SBR rubber provide maximum life and performance. Steel fasteners are heat treated grade 5 bolts. A special bonding agent is used to ensure a rubber to metal bond. Rubber material is mixed to specific Durometer, hardness.

Product Features:
  • MAXIMUM VIBRATION DAMPENING: Rubber cushion is made of high grade rubber that ensures maximum dampening of vibration and the ability to absorb over loads.
  • HEAVY GAUGE STEEL FRAME: The housing frame is made from heavy gauge steel with durability that extends the service life.
  • READY TO INSTALL: Most center supports include a sealed bearing and dust shield and are ready to install.
  • For Years: 1955-2018
  • Weight approx: 4 Lbs
  • BEARING ID / BORE: 1.5750 In. / 40 mm
  • CENTERLINE: 2.48 In. / 63 mm
  • Mount Width: 6.62 In. / 168 mm
  • Style: Round Frame
  • Not Pictured: Two Dust Shields
See More

Spicer – Drive Shaft Center Support Bearing (Part No.211499X)

Drive Shaft Center Support Bearing

from

$96.99
The part you need. The name you trust. Spicer driveline components deliver top performance and value. These center bearing kits are manufactured to the same genuine standards you’ve come to expect from the most reliable name in driveshaft parts.

Product Features:
  • Dana manufactured Spicer center bearing kit
  • Interchangeable with OE component
  • Comes as a complete kit to replace, repair, or refurbish
  • Latest production upgrades ensure genuine Spicer parts are as good or better than the OE parts they replace
See More

Anchor – Center Support Bearing Motor Mount: Center, 1 Piece (Part No.6056)

Center Support Bearing Motor Mount: Center, 1 Piece

from

$21.99
Anchor 6056 Center support bearings support a driveshaft between transmission and differential. This mount relieves stress on driveline components. Each part is engineered and designed to OE Standards. Natural and SBR rubber provide maximum life and performance. Steel fasteners are heat treated grade 5 bolts. A special bonding agent is used to ensure a rubber to metal bond. Rubber material is mixed to specific Durometer, hardness.

Product Features:
  • MAXIMUM VIBRATION DAMPENING: Rubber cushion is made of high grade rubber that ensures maximum dampening of vibration and the ability to absorb over loads.
  • HEAVY GAUGE STEEL FRAME: The housing frame is made from heavy gauge steel with durability that extends the service life.
  • READY TO INSTALL: Most center supports include a sealed bearing and dust shield and are ready to install.
  • For Years: 1955-2018
  • Weight approx: 3 Lbs
  • BEARING ID / BORE: 1.3780 In. / 35 mm
  • CENTERLINE: 2.28 In. / 58 mm
  • Mount Width: 6.62 In. / 168 mm
  • Style: Round Frame
  • Complete Mount
See More

Driveworks – Ball Bearing (Part No.S-HB-88107-A)

Ball Bearing

from

$19.99
Value-priced bearing meets all cataloged application requirements.
See More

Spicer – Drive Shaft Center Support Bearing (Part No.211175X)

Drive Shaft Center Support Bearing

from

$55.99
The part you need. The name you trust. Spicer driveline components deliver top performance and value. These center bearing kits are manufactured to the same genuine standards you’ve come to expect from the most reliable name in driveshaft parts.

Product Features:
  • Dana manufactured Spicer center bearing kit
  • Interchangeable with OE component
  • Comes as a complete kit to replace, repair, or refurbish
  • Latest production upgrades ensure genuine Spicer parts are as good or better than the OE parts they replace
See More

Spicer – Universal Joint, Greaseable 1410 Series (Part No.5-160X)

Universal Joint, Greaseable 1410 Series

from

$45.99
When you see the Spicer name, you know you are buying the highest quality product available. Spicer universal joints are no exception. Dana manufactures a full line of Spicer universal joints that are engineered to ensure longer life for vehicles in a wide variety of applications, from light vehicle to commercial and off-highway.

Product Features:
  • OE engineering and field tested experience is why the Spicer brand is the most trusted in the industry.
  • Forged with high-quality steel, these u-joints are heat treated and case-hardened with precision to specific levels, ensuring optimal strength and durability.
  • The process of precision grinding the seal and bearing surfaces helps to improve the life of the seal and bearing.
  • Zerk allows for lubricating at regular intervals to help extend the life of the part.
See More

Spicer – Universal Joint, Greaseable 1350 Series (Part No.5-178X)

Universal Joint, Greaseable 1350 Series

from

$44.99
When you see the Spicer name, you know you are buying the highest quality product available. Spicer universal joints are no exception. Dana manufactures a full line of Spicer universal joints that are engineered to ensure longer life for vehicles in a wide variety of applications, from light vehicle to commercial and off-highway.

Product Features:
  • OE engineering and field tested experience is why the Spicer brand is the most trusted in the industry.
  • Forged with high-quality steel, these u-joints are heat treated and case-hardened with precision to specific levels, ensuring optimal strength and durability.
  • The process of precision grinding the seal and bearing surfaces helps to improve the life of the seal and bearing.
  • Zerk allows for lubricating at regular intervals to help extend the life of the part.
See More

Spicer – Universal Joint (Part No.5-1350X)

Universal Joint

from

$45.99
You expect a lot from your vehicle, and Spicer Life Series (SPL) universal joints deliver. SPL universal joints consistently outperform competitors, so you can hit the road or trail with confidence. Check out the difference that SPL universal joints can make in your vehicle, and make sure you are getting the longer life, increased bearing capacity and lower maintenance costs that Spicer Life Series (SPL) can provide.
See More

Spicer – Universal Joint (Part No.5-1410X)

Universal Joint

from

$54.99
You expect a lot from your vehicle, and Spicer Life Series (SPL) universal joints deliver. SPL universal joints consistently outperform competitors, so you can hit the road or trail with confidence. Check out the difference that SPL universal joints can make in your vehicle, and make sure you are getting the longer life, increased bearing capacity and lower maintenance costs that Spicer Life Series (SPL) can provide.
See More

Dorman – Help – Driveshaft Flange Bolts (Part No.80992)

Driveshaft Flange Bolts

from

$22.49
This drive shaft bolt is designed to match the fit and function of the original part on specified vehicles. Made of quality materials, it is engineered for reliable performance.

Product Features:
  • Direct replacement – this engine mount bolt matches the fit and function of the factory part on specified years, makes and models
  • Ideal solution – this drive shaft bolt is a reliable replacement for an original part that is missing or has failed due to fatigue
  • Durable construction – this part is made from quality materials to ensure reliable performance and long service life
  • Trustworthy quality – backed by team of product experts in the United States and more than a century of automotive experience
See More

Most Popular Axle Shaft Universal Joints for 2021 Ford E-350 Super Duties

Enhance your 2021 Ford E-350 Super Duty with one of the 2 Axle Shaft Universal Joints we have in stock, starting at just $45.99.

Spicer – Universal Joint, Greaseable 1410 Series (Part No.5-160X)

Universal Joint, Greaseable 1410 Series

from

$45.99
When you see the Spicer name, you know you are buying the highest quality product available. Spicer universal joints are no exception. Dana manufactures a full line of Spicer universal joints that are engineered to ensure longer life for vehicles in a wide variety of applications, from light vehicle to commercial and off-highway.

Product Features:
  • OE engineering and field tested experience is why the Spicer brand is the most trusted in the industry.
  • Forged with high-quality steel, these u-joints are heat treated and case-hardened with precision to specific levels, ensuring optimal strength and durability.
  • The process of precision grinding the seal and bearing surfaces helps to improve the life of the seal and bearing.
  • Zerk allows for lubricating at regular intervals to help extend the life of the part.
See More

Spicer – Universal Joint (Part No.5-1410X)

Universal Joint

from

$54.99
You expect a lot from your vehicle, and Spicer Life Series (SPL) universal joints deliver. SPL universal joints consistently outperform competitors, so you can hit the road or trail with confidence. Check out the difference that SPL universal joints can make in your vehicle, and make sure you are getting the longer life, increased bearing capacity and lower maintenance costs that Spicer Life Series (SPL) can provide.
See More

Best-Selling 2021 Ford E-350 Super Duty Axle Flange Gasket

Upgrade your E-350 Super Duty with our best-selling Axle Flange Gasket.

Dorman – Axle Flange Gasket Kit (Part No.926-880)

Axle Flange Gasket Kit

from

$27.99
Ensure a leak-free repair when servicing axle bearings or parking brake shoes. This axle shaft flange seal is a direct replacement for the original gasket and should be replaced every time work is performed at the axle flange.

Product Features:


Product Features:
  • Ideal replacement – this axle shaft flange seal directly replaces the original gasket without having to visit the dealer
  • Required for routine service – this gasket should be replaced every time work is performed at the axle flange
  • Durable construction – this axle shaft flange gasket is made of tough, durable materials for leak-free performance
  • Quality tested – this flange gasket has been designed and tested for a guaranteed fit
See More

Top-Quality Drive Shaft Support Bolts for 2021 Ford E-350 Super Duties

Choose a high-quality OEM or aftermarket Drive Shaft Support Bolt for Ford E-350 Super Duties and enjoy top-notch performance from $22.49.

Dorman – Help – Driveshaft Flange Bolts (Part No.80992)

Driveshaft Flange Bolts

from

$22.49
This drive shaft bolt is designed to match the fit and function of the original part on specified vehicles. Made of quality materials, it is engineered for reliable performance.

Product Features:
  • Direct replacement – this engine mount bolt matches the fit and function of the factory part on specified years, makes and models
  • Ideal solution – this drive shaft bolt is a reliable replacement for an original part that is missing or has failed due to fatigue
  • Durable construction – this part is made from quality materials to ensure reliable performance and long service life
  • Trustworthy quality – backed by team of product experts in the United States and more than a century of automotive experience
See More

Top Picks for 2021 Ford E-350 Super Duty Center Support Bearings

Invest in one of our 3 durable Center Support Bearings for your 2021 Ford, knowing you’re getting trusted brands and expert craftsmanship.

Anchor – Center Support Bearing Motor Mount: Center, 1 Piece (Part No.6053)

Center Support Bearing Motor Mount: Center, 1 Piece

from

$38.99
Anchor 6053 Center support bearings support a driveshaft between transmission and differential. This mount relieves stress on driveline components. Each part is engineered and designed to OE Standards. Natural and SBR rubber provide maximum life and performance. Steel fasteners are heat treated grade 5 bolts. A special bonding agent is used to ensure a rubber to metal bond. Rubber material is mixed to specific Durometer, hardness.

Product Features:
  • MAXIMUM VIBRATION DAMPENING: Rubber cushion is made of high grade rubber that ensures maximum dampening of vibration and the ability to absorb over loads.
  • HEAVY GAUGE STEEL FRAME: The housing frame is made from heavy gauge steel with durability that extends the service life.
  • READY TO INSTALL: Most center supports include a sealed bearing and dust shield and are ready to install.
  • For Years: 1960-2015
  • Weight approx: 3 Lbs
  • BEARING ID / BORE: 1.5750 In. / 40 mm
  • CENTERLINE: 2.28 In. / 58 mm
  • Mount Width: 6.62 In. / 168 mm
  • No Studs
See More

Dorman – CNTR SUPPORT BEARING (Part No.934-007)

CNTR SUPPORT BEARING

from

$83.99
CNTR SUPPORT BEARING

Spicer – Drive Shaft Center Support Bearing (Part No.211359X)

Drive Shaft Center Support Bearing

from

$83.99
The part you need. The name you trust. Spicer driveline components deliver top performance and value. These center bearing kits are manufactured to the same genuine standards you’ve come to expect from the most reliable name in driveshaft parts.

Product Features:
  • Dana manufactured Spicer center bearing kit
  • Interchangeable with OE component
  • Comes as a complete kit to replace, repair, or refurbish
  • Latest production upgrades ensure genuine Spicer parts are as good or better than the OE parts they replace
See More

Suspension I-Beam Axle for 2021 Ford E-350 Super Duties

Make a smart move for your 2021 Ford E-350 Super Duty with products all priced from $249.99.

Dorman – BEAM AXLE (Part No.526-022)

BEAM AXLE

from

$249.99
BEAM AXLE

Dorman – BEAM AXLE (Part No.526-021)

BEAM AXLE

from

$249.99
BEAM AXLE

Top-Rated Drive Shafts and Axle Brands For Your 2021 Ford E-350 Super Duty

When it comes to finding the perfect Drive Shafts and Axle for your 2021 Ford E-350 Super Duty, Advance Auto Parts has you covered with a wide selection of high-quality OEM and aftermarket options from 3 trusted brands. We carry the most popular Drive Shafts and Axle brands including Spicer and Dorman, and more, all known for their exceptional customer ratings (average brand rating of 4.6 stars) and competitive prices, as low as $22.49. Purchasing a Drive Shafts and Axle from us here at Advance Auto Parts is a smart move for both you and your 2021 Ford E-350 Super Duty, providing peace of mind with parts that meet or exceed OEM standards.

Popular Spicer 2021 Ford E-350 Super Duty Drive Shafts and Axles

If you’re looking for a top-quality Drive Shafts and Axle for your 2021 Ford E-350 Super Duty, Advance Auto Parts has exactly what you need with our selection of Spicer Drive Shafts and Axles. We have 2 Spicer Drive Shafts and Axles in stock for this fitment, all known for their durability and precision fit. With prices starting at just $45.99 and an average cost of $50.49, you’ll find the perfect Drive Shafts and Axle for your needs and budget. Spicer Drive Shafts and Axles for the 2021 Ford E-350 Super Duty come highly rated, with over 11 customer reviews and an impressive average rating of 4.6 stars. Choosing a Spicer Drive Shafts and Axle from Advance Auto Parts is a smart move to ensure quality and value for your vehicle.
Universal Joint, Greaseable 1410 Series
from $45.99
(10)
Universal Joint, Greaseable 1410 Series
“Went in perfect”
Universal Joint
from $54.99
(1)
Universal Joint
“Spicer U joints are great. These are actual OE parts on my truck.”

Top-Quality Dorman 2021 Ford E-350 Super Duty Drive Shafts and Axles

For those in search of a high-quality Drive Shafts and Axle for their 2021 Ford E-350 Super Duty, Advance Auto Parts offers a great selection of Dorman Drive Shafts and Axles. With 1 Dorman Drive Shafts and Axles in stock, you can trust you’re getting top-tier parts designed for durability and a perfect fit. Prices for these Drive Shafts and Axles start at just $22.49, giving you a range of options to suit your budget. Backed by over 1 customer ratings and an average rating of 4.2 stars, Dorman Drive Shafts and Axles provide both reliability and excellent performance. Choosing a Dorman Drive Shafts and Axle from Advance Auto Parts is a smart investment in your vehicle’s performance and longevity.
Driveshaft Flange Bolts
from $22.49
(1)
Driveshaft Flange Bolts
“This item appears to be correct and my review is more of a bashing of AA help desk who apparently does not answer questions as you are lead to believe”

FAQs for 2021 Ford E-350 Super Duty Drive Shafts and Axles

What are the best-selling Drive Shafts and Axles for 2021 Ford E-350 Super Duties?

Out of 9 Drive Shafts and Axles that fit 2021 Ford E-350 Super Duties, the following parts are the top sellers:

What’s the price range for 2021 Ford E-350 Super Duty Drive Shafts and Axles?

The prices of Drive Shafts and Axles for the 2021 Ford E-350 Super Duty range from $22.49 up to $249.99 for the most premium parts.

What is the average price of a Drive Shafts and Axle for a 2021 Ford E-350 Super Duty?

The average price for Drive Shafts and Axles for the 2021 Ford E-350 Super Duty is $95.38. Keep in mind the variety of part types within our Drive Shafts and Axle category, where you are likely to find a wide range of prices across a variety of parts and components.

Does Advance Auto Parts sell Drive Shafts and Axles for other Ford E-350 Super Duty model years?

Yes, we carry Drive Shafts and Axles for 23 model years of Ford E-350 Super Duties between 2000 and 2025. The following model years are the most popular for Drive Shafts and Axle purchases: 2022, 2019, 2018, 2017, 2016, 2015, 2014, 2013, and 2012.

What are the cheapest Drive Shafts and Axles for my 2021 Ford E-350 Super Duty?

The cheapest 2021 Ford E-350 Super Duty Drive Shafts and Axles we carry are:

Does Advance Auto Parts sell Drive Shafts and Axles for any other 2021 Ford models?

What are the top-rated Drive Shafts and Axles that fit the 2021 Ford E-350 Super Duty?

Based on 24 reviews by customers, our 2021 Ford E-350 Super Duty Drive Shafts and Axles have an average customer rating of 5 stars. These are the highest-rated categories of Drive Shafts and Axles for the 2021 Ford E-350 Super Duty and their top-rated products:

What types of Drive Shafts and Axles do you sell for my 2021 Ford E-350 Super Duty?

As of 3/1/26, these are some of the most in-demand types of Drive Shafts and Axles for a 2021 Ford E-350 Super Duty:

Can I get help with 2021 Ford E-350 Super Duty Drive Shafts and Axle orders?

Contact our customer support team by chat or phone, through the help desk page, where you can find instant answers about Ford Drive Shafts and Axles and more.

What is your return policy for Ford E-350 Super Duty Drive Shafts and Axles?

Advance Auto Parts keeps returns simple. For new Ford E-350 Super Duty Drive Shafts and Axles and accessories, your online orders can be returned, in their original condition, within 45 days. For requirements, see the returns page.