2001 Ford E-350 Super Duty Engine Cooling Parts

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Keep Your 2001 Ford E-350 Super Duty in Top Shape with Quality Engine Cooling Parts

Whether you’re repairing or upgrading your Engine Cooling Part, using high-quality parts is key to keeping your 2001 Ford E-350 Super Duty looking sharp and performing at its best. At Advance Auto Parts we carry a wide selection of dependable options, including Water Pumps, Water Pump Gaskets, and Thermostats. Whether you’re replacing a damaged part or enhancing your truck’s style and protection, you’ll find exactly what you need to get the job done right.

Top-Rated Engine Cooling Parts from Trusted Brands

Looking for a reliable Engine Cooling Part? We’ve got you covered with options from brands you know and trust like Felpro, Carquest Premium, and Dorman. For example, Felpro Engine Cooling Parts start at just $6.99 with an average 4.6 star rating. Carquest Premium and Dorman offer similar pricing and quality, backed by strong customer feedback. With over 1,405 reviews and a solid 4 star average, you can shop with confidence knowing other Ford E-350 Super Duty owners approve.

Competitive Prices and Extensive Inventory

The average price for a 2001 Ford E-350 Super Duty Engine Cooling Part at Advance Auto Parts is around $80.72, with a range that starts at $4.79 and goes up to $416.99. With 63 options in stock from 10 trusted brands, finding the right fit is easy. Popular picks like Multi-Purpose O-Ring, High Flow Thermostat: 170 Degrees, and UltraStat Thermostat: 195 Degrees start at just $11.99 and offer a great balance of form and function.

Explore Related Parts

While you’re upgrading or replacing your Engine Cooling Part, don’t forget to check out other key components like Blend Doors and Blower Motor and Related Products. At Advance Auto Parts, we’re here to help you keep your 2001 Ford E-350 Super Duty in peak condition, inside and out.

Essential 2001 Ford E-350 Super Duty Engine Cooling Parts

US MOTOR WORKS – Water Pump with Fan Clutch (Part No.MCK1064)

Water Pump with Fan Clutch

from

$189.99
US Motor Works Professional Series Water Pump with Fan Clutch are designed to replace the mechanical components of a cooling system. A proper water pump replacement should include a new fan clutch as the two are connected to the same shaft and work together to move the air and cooling fluid. Replacing one without the other can damage the new part and cause repeat work or engine trouble. This matched set will allow your vehicle continued operation in the demanding environment of today’s engine. All components are brand new and QA inspected for perfect fit and function. Restore your cooling power by installing a US Motor Works Professional Series Water Pump with Fan Clutch.

Product Features:
  • Fan clutch mounts to the water pump and should be replaced at the same time.
  • Matched set for proper water pump or fan clutch replacement
  • Includes mounting hardware, gaskets and accessories as required.
  • Complete mechanical cooling parts replacement
  • Factory tested and 100% new product
  • Meets or exceeds OEM quality
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Carquest Premium – High Flow Thermostat: 170 Degrees (Part No.13967)

High Flow Thermostat: 170 Degrees

from

$14.99
Carquest Premium Thermostats are manufactured with OEM quality materials and safety standards by an OE Supplier. This thermostat will meet and exceed the expectations of the OE thermostat to insure the best product for your cooling system. With the enlarged Orpheus opening, this high flowing thermostat will allow for more gallons per second to flow. This will allow for the engine to cool down at a faster rate compared to the OE to allow for quick and precise cooling for your engine. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant. Offset design, air relief valve, and OEM style seals included where applicable.

Product Features:
  • Larger opening for increased coolant flow
  • Increased strength and durability
  • High grade stainless steel and copper construction
  • Meets or exceeds OEM standards
  • Consistent and precise response to cooling system needs
  • 100% tested and calibrated
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Carquest Premium – Universal Reverse Rotation Severe Duty Electronic Fan Clutch (Part No.216038)

Universal Reverse Rotation Severe Duty Electronic Fan Clutch

from

$101.99
Please note: Advance Auto Parts is proud to carry comparable exact-fit parts from multiple vendors, as such, the item you receive may be one of two quality brands. Both brands meet the same fitment requirements and are equal in their performance and specifications.

Product Features:
  • Designed, tested, and built by application
  • OE performance, fit, and appearance
  • Precision machined
  • Out of box installation
  • Designed, tested, and built by application
  • OE performance, fit, and appearance
  • Precision machined
  • Out of box installation
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Felpro – Engine Water Pump Gasket (Part No.35478)

Engine Water Pump Gasket

from

$7.99
Fel-Pro gaskets are specifically designed for the repair environment to deliver a reliable seal on even the most troublesome applications. Designed for imperfect sealing surfaces and manufactured with proprietary materials, you can count on Fel-Pro for innovative sealing solutions for the real-world repair environment.

Product Features:
  • Meets or exceeds all original equipment specifications
  • Application specific design
  • Manufactured for the sealing repair environment
  • Validated for fit, form, and function
  • Quality that you can trust
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Motorad – Engine Coolant Thermostat Housing Assembly Thermostat: With Seal, 192 Degrees (Part No.5190KT)

Engine Coolant Thermostat Housing Assembly Thermostat: With Seal, 192 Degrees

from

$44.99
Kit includes thermostat, housing, and all necessary seals/gaskets to do the complete job. These individual parts are manufactured with OEM quality materials and safety standards by an OE Supplier. This thermostat and housing will meet and exceed the expectations of the OE thermostat to insure the best product for your cooling system. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant. Offset design, air relief valve, and OEM style seals included where applicable.

Product Features:


    Product Features:
    • High grade stainless steel and copper construction
    • Meets or exceeds OEM standards
    • Consistent and precise response to cooling system needs
    • Original equipment design for worry-free direct fit replacement
    • 100% tested and calibrated
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Victor Reinz – Engine Coolant Thermostat Housing Seal (Part No.71-14045-00)

Engine Coolant Thermostat Housing Seal

from

$4.99
With Victor Reinz gaskets, you can be sure you are getting sealing solutions that deliver OE quality gasket technology and engineering. That is because Victor Reinz is an original equipment supplier and the trusted choice of manufacturers the world over, offering broad coverage for foreign and domestic cars and trucks. In Victor Reinz gasket sets, you get the right combination of components needed for fast, long-lasting repairs.

Product Features:
  • Choosing Victor Reinz assures getting OE quality parts in gaskets sets that have the coverage, contents, packaging and electronic cataloging to best meet the needs of the aftermarket.
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Imperial – Electric Fan, 14" Diameter (Part No.226114)

Electric Fan, 14" Diameter

from

$99.99
Our products are engineered and tested to provide years of trouble free operation. Backed by over 50 years of mobile a/c experience, fix it once and fix it right with Imperial.

Product Features:
  • Motors built and tested to quality specifications
  • 14 in. universal fit reversible fan
  • 1250 CFM
  • UNIVERSAL fan, NOT a direct OE replacement. Measure core and verify space.
  • Motors built and tested to quality specifications
  • 14 in. universal fit reversible fan
  • 1250 CFM
  • UNIVERSAL fan, NOT a direct OE replacement. Measure core and verify space.
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Carquest Premium – Temperature Sender With Gauge and Thread Sealant (Part No.WTC1037)

Temperature Sender With Gauge and Thread Sealant

from

$16.99
Product Features:
  • Designed to meet or exceed OE specifications for fit, form and function
  • 100% factory resistance calibrated to ensure precision tolerances, resulting in extremely accurate temperature for optimal performance
  • OE precision matched thermistor ensuring sensors match OE output resistances across all temperature positions
  • O-rings, seals or thread sealant are included if required
  • Weather-tight connectors prevent leaks and corrosion for longer life
  • Extensive design validation testing and 100% end-of-line tested
  • Carquest Vehicle Solutions Technical Support available from ASE certified technicians: 1-866-687-5413
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Dorman – Clutch Fan Blade: Plastic, Cost Effective and Reliable (Part No.620-159)

Clutch Fan Blade: Plastic, Cost Effective and Reliable

from

$101.99
Replace your damaged cooling fan blade with this direct replacement. This vehicle-specific application is engineered for a perfect fit and is made from quality materials to ensure durability and restore proper cooling system operation.

Product Features:
  • Direct replacement – this engine cooling fan blade fits and functions like the original equipment fan blade
  • Quality construction – manufactured from premium materials for a long service life
  • Excellent value – original equipment quality at a lower price
  • Quality tested – has undergone testing to ensure proper fit and performance
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Felpro – Engine Water Pump Gasket Kit (Part No.ES 73054)

Engine Water Pump Gasket Kit

from

$11.99
Fel-Pro® gaskets are specifically designed for the repair environment to deliver a reliable seal on even the most troublesome applications. Designed for imperfect sealing surfaces and manufactured with proprietary materials, you can count on Fel-Pro for innovative sealing solutions for the real-world repair environment.

Product Features:
  • Meets or exceeds all original equipment specifications
  • Application specific design to ensure a perfect fit
  • Manufactured for the sealing repair environment
  • Validated for fit, form, and function
  • Unsurpassed quality you can trust
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Dorman – Engine Coolant Water Outlet (Part No.902-1110)

Engine Coolant Water Outlet

from

$103.99
This replacement engine coolant water outlet is engineered to match the fit and durability of the stock engine coolant water outlet on specified vehicles. It is designed to withstand extreme temperature changes to extend service life.

Product Features:
  • Ideal replacement – this engine coolant water outlet directly replaces the original water outlet on specified vehicle years, makes and models
  • Durable construction – this part is specifically designed to withstand extreme temperature changes and resist cracking and leaking
  • Cost-effective and reliable – offers original manufacturer quality at lower cost than getting replacement at dealer
  • Industry-leading design – professionally engineered by the aftermarket leader in replacement water outlets
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Carquest Premium – Coolant Housing/Water Outlet (Part No.CH1108)

Coolant Housing/Water Outlet

from

$72.99
Carquest Premium Thermostat Housings are manufactured with OEM quality materials and safety standards by an OE Supplier. This housing will meet and exceed the expectations of the OE thermostat to insure the best product for your cooling system. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. The construction of this housing is improved over the OE design to fix and update any issues that the OE design may have had.

Product Features:
  • Easy, one step fit and installation
  • No special tools required
  • Meets or exceeds all OEM standards
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Felpro – Engine Coolant Thermostat Housing Gasket (Part No.35702)

Engine Coolant Thermostat Housing Gasket

from

$4.79
Fel-Pro gaskets offer 100% vehicle sealing with application-specific materials to give you sealing solutions with the performance and durability professionals trust.

Product Features:
  • Meets or exceeds all original equipment specifications
  • Application specific design to ensure a perfect fit
  • Engineered and manufactured specifically for the repair environment
  • Unsurpassed quality you can trust
  • Validated for fit, form, and function
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Driveworks Water Pumps – Water Pump: New, Installation Gasket Included (Part No.58-661)

Water Pump: New, Installation Gasket Included

from

$119.99
Driveworks Water Pumps offer a complete replacement part solution, with application coverage that spans from antique to present-day vehicles. All units are 100% tested and engineered to meet or exceed OEM performance, providing you a quality product you and your vehicle can rely on. All units are manufacturered with brand new components and are packaged with all gaskets required for replacement.

Product Features:
  • 100% Factory tested for leakage and dimensional precision
  • Manufactured to original casting specifications to ensure a proper fit and proper water flow for efficient cooling
  • Bearings made of heat-treated carbon or carburized steel are sealed and lubricated to ensure smooth performance throughout units life
  • Assembled with new, high-quality unitized shaft seals to prevent premature leakage
  • Supplied with gasket and other seals/gaskets as applicable per application to help complete the job
  • This pump is driven by the accessory belt and we recommend replacement if nearing service recommendation
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Dorman – Pressurized Coolant Reservoir: White, Plastic; Metal, Original Equipment Replacement (Part No.603-811)

Pressurized Coolant Reservoir: White, Plastic; Metal, Original Equipment Replacement

from

$111.99
This replacement engine coolant reservoir is manufactured from quality materials to withstand the stresses of underhood heat and engine vibration. It is engineered and manufactured to match the fit and function of the original part.

Product Features:
  • Direct replacement – this engine coolant reservoir matches the fit and function of the original part
  • Ideal solution – engineered for a seamless installation
  • Durable construction – manufactured from quality materials to withstand underhood heat and vibration
  • Trustworthy design – backed by 100 years of automotive aftermarket experience
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Imperial – Thermostatic Fan Control – Adjustable (Part No.226208)

Thermostatic Fan Control - Adjustable

from

$69.99
Our products are engineered and tested to provide years of trouble free operation. Backed by over 50 years of mobile a/c experience, fix it once and fix it right with Imperial.

Product Features:
  • Adjustable thermostatic fan control
  • 160 Deg. F – 210 Deg. F thread-in probe
  • For use with Imperial electric fans
  • Thread-in probe for installation in water jacket or radiator
  • Contains gaskets, O-rings, or seals to properly replace the product
  • Brass construction for accurate temperature sensing
  • Zinc coated terminal to resist corrosion
  • Vehicle specific applications
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Felpro – Engine Water Pump O-Ring (Part No.35499)

Engine Water Pump O-Ring

from

$3.29
Fel-Pro® gaskets are specifically designed for the repair environment to deliver a reliable seal on even the most troublesome applications. Designed for imperfect sealing surfaces and manufactured with proprietary materials, you can count on Fel-Pro for innovative sealing solutions for the real-world repair environment.

Product Features:
  • Meets or exceeds all original equipment specifications
  • Application specific design
  • Manufactured for the sealing repair environment
  • Validated for fit, form, and function
  • Quality that you can trust
See More

Felpro – Engine Water Pump Gasket (Part No.35812)

Engine Water Pump Gasket

from

$3.49
Fel-Pro gaskets offer 100% vehicle sealing with application-specific materials to give you sealing solutions with the performance and durability professionals trust.

Product Features:
  • Meets or exceeds all original equipment specifications
  • Application specific design
  • Manufactured for the sealing repair environment
  • Validated for fit, form, and function
  • Quality that you can trust
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Dorman – Help – Engine Coolant Reservoir Cap: Twist, Plastic, 1 Pack (Part No.54208)

Engine Coolant Reservoir Cap: Twist, Plastic, 1 Pack

from

$16.99
Cracked or lost the original engine coolant reservoir cap- Replace it seamlessly and effectively with this precisely engineered, direct replacement cap.

Product Features:
  • Direct replacement – this engine coolant reservoir cap directly replaces a cracked or lost original cap
  • Application specific – made to match dimensions of reservoir cap on only certain vehicle years, makes and models
  • Seamless fit – reverse-engineered from the original equipment to fit perfectly
  • Excellent value – a quick, easy replacement that’s less expensive than going back to the dealership
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Carquest Premium – Standard Reservoir Cap: 16 PSI (Part No.10238)

Standard Reservoir Cap: 16 PSI

from

$10.99
Crafted to meet the exact specifications set by Original Equipment Manufacturers (OEM), these products are engineered for effortless installation and removal. Constructed from premium-grade components, incorporating proper relief and vacuum valves, they ensure optimal performance even in the most demanding automotive cooling systems. Rigorously quality-tested, these components provide exceptional, out-of-the-box performance and superior durability to meet or exceed the highest standards of today’s vehicles.

Product Features:
  • Maintains proper cooling system pressure
  • Easy installation and removal
  • 100% tested to ensure proper pressure and longevity
  • Meets all OEM specifications
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Edelbrock – Waterneck for Small Block Ford (Part No.48143)

Waterneck for Small Block Ford

from

$25.49
Edelbrock part No. 48143 Waterneck is designed for use with small-block Ford V8 engine applications. This Black water neck is a great way to finish off your engine. It features a 15 deg. neck and O-ring design for an improved seal, which also allows for removal without requiring a new gasket. Fits any 1-1/2″ diameter outlet hose.
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Carquest Premium – Radiator: With Transmission Oil Cooler (Part No.434080)

Radiator: With Transmission Oil Cooler

from

$416.99
Carquest Premium Radiators offer one of the largest product ranges in the aftermarket, covering more than 95% of the popular automotive and light truck applications. Carquest Premium Radiators meet or exceed original equipment specifications, ensuring that products fit and perform just as well or better than the original parts, providing you peace of mind.

Product Features:
  • Our B-type tubes feature central reinforcement to provide greater tolerance to pressure. Stronger tube design means drastically reduced probability of tube failure.
  • Our deep extrusion header provides a stronger tube to header joint which is more resistant to the effects of vibration and thermal tube expansion, virtually eliminating tube to header leaks.
  • Our fin edges are folded for increased stability and heat disbursement properties.
  • Our included “multi-fit” attachments allow one radiator to cover multiple vehicle applications without sacrificing OE fit. This results in wider vehicle coverage with substantially less inventory.
  • Thermal expansion cuts allow for longer life and reduce failure rates by allowing improved core expansion and contraction during normal heat cycles.
  • We design and manufacture all our radiators to meet or even exceed Original Equipment specifications. We take pride in producing the most reliable replacement parts in the market.
  • We use longer header tabs for increased pressure resistance. This reduces the potential for tank to header leaks.
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Carquest Premium – Radiator (Part No.434081)

Radiator

from

$315.99
Carquest Premium Radiators offer one of the largest product ranges in the aftermarket, covering more than 95% of the popular automotive and light truck applications. Carquest Premium Radiators meet or exceed original equipment specifications, ensuring that products fit and perform just as well or better than the original parts, providing you peace of mind.

Product Features:
  • Our B-type tubes feature central reinforcement to provide greater tolerance to pressure. Stronger tube design means drastically reduced probability of tube failure.
  • Our deep extrusion header provides a stronger tube to header joint which is more resistant to the effects of vibration and thermal tube expansion, virtually eliminating tube to header leaks.
  • Our fin edges are folded for increased stability and heat disbursement properties.
  • Our included “multi-fit” attachments allow one radiator to cover multiple vehicle applications without sacrificing OE fit. This results in wider vehicle coverage with substantially less inventory.
  • Thermal expansion cuts allow for longer life and reduce failure rates by allowing improved core expansion and contraction during normal heat cycles.
  • We design and manufacture all our radiators to meet or even exceed Original Equipment specifications. We take pride in producing the most reliable replacement parts in the market.
  • We use longer header tabs for increased pressure resistance. This reduces the potential for tank to header leaks.
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Carquest Premium – Radiator Cap Tester Adapter (Part No.12029)

Radiator Cap Tester Adapter

from

$41.99
Tester adapter for the MT-300 cooling system pressure testers. Professional grade test equipment to ensure an automotive cooling system is operating at the correct pressure. Made from high quality materials to ensure durability. Designed to test automotive coolant caps.

Product Features:
  • Machined metal construction
  • Works with MT-300 pressure tester
  • Tests coolant caps
  • Professional quality
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Carquest Premium – Engine Coolant Temperature Sensor (Part No.WTA1073)

Engine Coolant Temperature Sensor

from

$27.99
Carquest Premium coolant temperature sensors and switches are designed to perform in harsh engine environments and meet or exceed original equipment (O.E.) specifications. Built by manufacturers that meet IATF 16949 certified framework, an internationally recognized proof of quality in the automotive industry, Carquest Premium coolant temperature sensors and switches undergo extensive validation testing to ensure long-lasting performance and reliability. Carquest Premium coolant temperature sensors and switches are part of our Carquest Vehicle Solutions, which is a full line of engine management and electronics products that help control ignition, fuel delivery and emission systems. Carquest Vehicle Solutions are OE-quality parts designed, engineered and tested by world-class manufacturers to ensure a reliable and long-lasting repair.

Product Features:
  • Designed to meet or exceed OE specifications for fit, form and function
  • 100% factory resistance calibrated to ensure extremely accurate temperature readings for optimal performance
  • O-rings, seals or thread sealant are included if required
  • Wires, clips and probe length match OE (where applicable)
  • Weather-tight connectors prevent leaks and corrosion for longer life
  • Extensive design validation testing and 100% end-of-line tested
  • Carquest Vehicle Solutions Technical Support available from ASE certified technicians: 1-866-687-5413
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Most Popular Water Pumps for 2001 Ford E-350 Super Duties

Enhance your 2001 Ford E-350 Super Duty with one of the 5 Water Pumps we have in stock, starting at just $56.99.

Carquest Premium – Engine Water Pump: New, Gasket/Seals Included (Part No.T4207)

Engine Water Pump: New, Gasket/Seals Included

from

$124.99
This premium water pump uses new high-quality components and is designed to meet or exceed OE specifications. This pump is 100% tested to ensure quality. Bearings, gaskets, seals, impeller, hub and housing are all designed for long-lasting service life. All necessary gaskets and seals are included.

Product Features:
  • Built to meet or exceed OE fit, form and function
  • All components necessary for installation are supplied with pump
  • 100% tested for reliable performance
  • Follow all enclosed instructions to maximize pump life and validate warranty
  • Additional Notes: Includes gasket
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Carquest Premium – Engine Water Pump: New, Gasket/Seals Included (Part No.T4196)

Engine Water Pump: New, Gasket/Seals Included

from

$56.99
This premium water pump uses new high-quality components and is designed to meet or exceed OE specifications. This pump is 100% tested to ensure quality. Bearings, gaskets, seals, impeller, hub and housing are all designed for long-lasting service life. All necessary gaskets and seals are included.

Product Features:
  • Built to meet or exceed OE fit, form and function
  • All components necessary for installation are supplied with pump
  • 100% tested for reliable performance
  • Follow all enclosed instructions to maximize pump life and validate warranty
  • Additional Notes: Includes gasket
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Carquest Premium – Engine Water Pump: New (Part No.T4194)

Engine Water Pump: New

from

$129.99
This premium water pump uses new high-quality components and is designed to meet or exceed OE specifications. This pump is 100% tested to ensure quality. Bearings, gaskets, seals, impeller, hub and housing are all designed for long-lasting service life. All necessary gaskets and seals are included.

Product Features:
  • This pump is used on accessory belt driven applications
  • Used mostly on models equipped with a fan clutch
  • It is highly recommended that the fan clutch be replaced with the water pump
  • Equipped with weep chamber or similar feature to help prevent unnecessary replacement
  • All gaskets or seals necessary for installation are supplied with pump
  • Additional Notes: Includes gasket
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Driveworks Water Pumps – Water Pump – Domestic Reman (Part No.58-554)

Water Pump - Domestic Reman

from

$108.99
100% leak testing And hub-pull testing ensures reliable performance. O.E.-supplied NEW unitized seals ensure long-lasting, trouble-free performance. Unlike other aftermarket manufacturers, CARDONE installs the proper O.E. specified bearing design to meet the specific radial And axial load requirements of each application. This ensures longer bearing life And reliable performance. Original casting specifications are strictly followed to ensure proper fit for easy installation And proper water flow for maximum cooling.

Product Features:
  • 100% leak testing and hub-pull testing ensures reliable performance.
  • O.E.-supplied NEW unitized seals ensure long-lasting, trouble-free performance.
  • The proper O.E. specified bearing design is installed to meet the specific radial and axial load requirements of each application. This ensures longer bearing life and reliable performance.
  • Thermostat seal and mounting gasket are supplied for ease of installation (where applicable).
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Carquest Premium – Engine Water Pump: New, Gasket/Seals Included (Part No.T5094)

Engine Water Pump: New, Gasket/Seals Included

from

$164.99
This premium water pump uses new high-quality components and is designed to meet or exceed OE specifications. This pump is 100% tested to ensure quality. Bearings, gaskets, seals, impeller, hub and housing are all designed for long-lasting service life. All necessary gaskets and seals are included.

Product Features:
  • Built to meet or exceed OE fit, form and function
  • All components necessary for installation are supplied with pump
  • 100% tested for reliable performance
  • Follow all enclosed instructions to maximize pump life and validate warranty
  • Additional Notes: Includes gasket
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Best-Selling 2001 Ford E-350 Super Duty Water Pump Gaskets

Upgrade your E-350 Super Duty with one of our 2 best-selling Water Pump Gaskets, earning an average 4.5 stars rating across 12 reviews.

Felpro – Engine Water Pump Gasket (Part No.35612)

Engine Water Pump Gasket

from

$10.99
Fel-Pro gaskets are specifically designed for the repair environment to deliver a reliable seal on even the most troublesome applications. Designed for imperfect sealing surfaces and manufactured with proprietary materials, you can count on Fel-Pro for innovative sealing solutions for the real-world repair environment.

Product Features:
  • Meets or exceeds all original equipment specifications
  • Application specific design
  • Manufactured for the sealing repair environment
  • Validated for fit, form, and function
  • Quality that you can trust
See More

Felpro – Engine Water Pump Gasket (Part No.35478)

Engine Water Pump Gasket

from

$7.99
Fel-Pro gaskets are specifically designed for the repair environment to deliver a reliable seal on even the most troublesome applications. Designed for imperfect sealing surfaces and manufactured with proprietary materials, you can count on Fel-Pro for innovative sealing solutions for the real-world repair environment.

Product Features:
  • Meets or exceeds all original equipment specifications
  • Application specific design
  • Manufactured for the sealing repair environment
  • Validated for fit, form, and function
  • Quality that you can trust
See More

Top-Quality Thermostats for 2001 Ford E-350 Super Duties

Choose a high-quality OEM or aftermarket Thermostat for Ford E-350 Super Duties and enjoy top-notch performance from $12.99.

Carquest Premium – Standard Thermostat: 195 Degrees (Part No.13779)

Standard Thermostat: 195 Degrees

from

$16.99
Carquest Premium Thermostats are manufactured with OEM quality materials and safety standards by an OE Supplier. This thermostat will meet and exceed the expectations of the OE thermostat to insure the best product for your cooling system. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant. Offset design, air relief valve, and OEM style seals included where applicable.

Product Features:
  • High grade stainless steel and copper construction
  • Meets or exceeds OEM standards
  • Consistent and precise response to cooling system needs
  • Original equipment design for worry-free direct fit replacement
  • 100% tested and calibrated
See More

Carquest Premium – High Flow Thermostat: 170 Degrees (Part No.13967)

High Flow Thermostat: 170 Degrees

from

$14.99
Carquest Premium Thermostats are manufactured with OEM quality materials and safety standards by an OE Supplier. This thermostat will meet and exceed the expectations of the OE thermostat to insure the best product for your cooling system. With the enlarged Orpheus opening, this high flowing thermostat will allow for more gallons per second to flow. This will allow for the engine to cool down at a faster rate compared to the OE to allow for quick and precise cooling for your engine. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant. Offset design, air relief valve, and OEM style seals included where applicable.

Product Features:
  • Larger opening for increased coolant flow
  • Increased strength and durability
  • High grade stainless steel and copper construction
  • Meets or exceeds OEM standards
  • Consistent and precise response to cooling system needs
  • 100% tested and calibrated
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Carquest Premium – Standard Thermostat: 180 Degrees (Part No.13778)

Standard Thermostat: 180 Degrees

from

$15.99
Carquest Premium Thermostats are manufactured with OEM quality materials and safety standards by an OE Supplier. This thermostat will meet and exceed the expectations of the OE thermostat to insure the best product for your cooling system. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant. Offset design, air relief valve, and OEM style seals included where applicable.

Product Features:
  • High grade stainless steel and copper construction
  • Meets or exceeds OEM standards
  • Consistent and precise response to cooling system needs
  • Original equipment design for worry-free direct fit replacement
  • 100% tested and calibrated
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Motorad UltraStats – UltraStat Thermostat: 180 Degrees (Part No.5228-180JV)

UltraStat Thermostat: 180 Degrees

from

$18.99
This premium upgraded thermostat is everything you were looking for. UltraStat Thermostats are the toughest thermostats on the market. All heavy gauge stainless steel construction provides long-life durability, as well as complete corrosion resistance. Exclusive BLVT Valve technology minimizes thermal shock to cooling system components. This is the perfect upgrade to help insure your cooling system is working exactly as you need and expect it to for longevity.

Product Features:
  • Exclusive BLVT Valve Technology minimizes thermal shock to cooling system components
  • Heavy gauge stainless steel components offer increased reliability and long-lasting durability
  • Stainless steel thermal element for unmatched corrosion resistance and revolutionary REAX wax mixture provides quicker reaction time
  • AccuSpring Design for stable temperature control and increased cabin comfort
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Carquest Premium – High Flow Thermostat: 180 Degrees (Part No.13968)

High Flow Thermostat: 180 Degrees

from

$12.99
Carquest Premium Thermostats are manufactured with OEM quality materials and safety standards by an OE Supplier. This thermostat will meet and exceed the expectations of the OE thermostat to insure the best product for your cooling system. With the enlarged Orpheus opening, this high flowing thermostat will allow for more gallons per second to flow. This will allow for the engine to cool down at a faster rate compared to the OE to allow for quick and precise cooling for your engine. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant. Offset design, air relief valve, and OEM style seals included where applicable.

Product Features:
  • Larger opening for increased coolant flow
  • Increased strength and durability
  • High grade stainless steel and copper construction
  • Meets or exceeds OEM standards
  • Consistent and precise response to cooling system needs
  • 100% tested and calibrated
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Carquest Premium – Standard Thermostat: 192 Degrees (Part No.14269)

Standard Thermostat: 192 Degrees

from

$17.99
Carquest Premium Thermostats are manufactured with OEM quality materials and safety standards by an OE Supplier. This thermostat will meet and exceed the expectations of the OE thermostat to insure the best product for your cooling system. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant. Offset design, air relief valve, and OEM style seals included where applicable.

Product Features:
  • High grade stainless steel and copper construction
  • Meets or exceeds OEM standards
  • Consistent and precise response to cooling system needs
  • Original equipment design for worry-free direct fit replacement
  • 100% tested and calibrated
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Carquest Premium – Standard Thermostat: 195 Degrees (Part No.14989)

Standard Thermostat: 195 Degrees

from

$16.99
Carquest Premium Thermostats are manufactured with OEM quality materials and safety standards by an OE Supplier. This thermostat will meet and exceed the expectations of the OE thermostat to insure the best product for your cooling system. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant. Offset design, air relief valve, and OEM style seals included where applicable.

Product Features:
  • High grade stainless steel and copper construction
  • Meets or exceeds OEM standards
  • Consistent and precise response to cooling system needs
  • Original equipment design for worry-free direct fit replacement
  • 100% tested and calibrated
See More

Motorad UltraStats – UltraStat Thermostat: 195 Degrees (Part No.5228-195JV)

UltraStat Thermostat: 195 Degrees

from

$18.99
This premium upgraded thermostat is everything you were looking for. UltraStat Thermostats are the toughest thermostats on the market. All heavy gauge stainless steel construction provides long-life durability, as well as complete corrosion resistance. Exclusive BLVT Valve technology minimizes thermal shock to cooling system components. This is the perfect upgrade to help insure your cooling system is working exactly as you need and expect it to for longevity.

Product Features:
  • Exclusive BLVT Valve Technology minimizes thermal shock to cooling system components
  • Heavy gauge stainless steel components offer increased reliability and long-lasting durability
  • Stainless steel thermal element for unmatched corrosion resistance and revolutionary REAX wax mixture provides quicker reaction time
  • AccuSpring Design for stable temperature control and increased cabin comfort
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Motorad UltraStats – Thermostat: 192 Degrees (Part No.5378-192)

Thermostat: 192 Degrees

from

$36.99
UltraStat Thermostats are the toughest thermostats on the market. All heavy gauge stainless steel construction provides long-life durability, as well as complete corrosion resitance. Exclusive BLVT Valve technology minimizes thermal shock to cooling system components.

Product Features:
  • Heavy gauge stainless steel components offer increased reliability and long-lasting durability
  • Exclusive BLVT Valve Technology minimizes thermal shock to cooling system components
  • Stainless steel thermal element for unmatched corrosion resistance and revolutionary REAX wax mixture provides quicker reaction time
  • AccuSpring Design for stable temperature control and increased cabin comfort
See More

Motorad – Engine Coolant Thermostat Housing Assembly Thermostat: With Seal, 185 Degrees (Part No.5004KT)

Engine Coolant Thermostat Housing Assembly Thermostat: With Seal, 185 Degrees

from

$40.99
Kit includes thermostat, housing, and all necessary seals/gaskets to do the complete job. These individual parts are manufactured with OEM quality materials and safety standards by an OE Supplier. This thermostat and housing will meet and exceed the expectations of the OE thermostat to insure the best product for your cooling system. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant. Offset design, air relief valve, and OEM style seals included where applicable.

Product Features:


Product Features:
  • High grade stainless steel and copper construction
  • Meets or exceeds OEM standards
  • Consistent and precise response to cooling system needs
  • Original equipment design for worry-free direct fit replacement
  • 100% tested and calibrated
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Top Picks for 2001 Ford E-350 Super Duty Radiators

Invest in one of our 2 durable Radiators for your 2001 Ford, knowing you’re getting trusted brands and expert craftsmanship.

Carquest Premium – Radiator (Part No.431359)

Radiator

from

$327.99
Carquest Premium Radiators offer one of the largest product ranges in the aftermarket, covering more than 95% of the popular automotive and light truck applications. Carquest Premium Radiators meet or exceed original equipment specifications, ensuring that products fit and perform just as well or better than the original parts, providing you peace of mind.

Product Features:
  • Our B-type tubes feature central reinforcement to provide greater tolerance to pressure. Stronger tube design means drastically reduced probability of tube failure.
  • Our deep extrusion header provides a stronger tube to header joint which is more resistant to the effects of vibration and thermal tube expansion, virtually eliminating tube to header leaks.
  • Our fin edges are folded for increased stability and heat disbursement properties.
  • Our included “multi-fit” attachments allow one radiator to cover multiple vehicle applications without sacrificing OE fit. This results in wider vehicle coverage with substantially less inventory.
  • Thermal expansion cuts allow for longer life and reduce failure rates by allowing improved core expansion and contraction during normal heat cycles.
  • We design and manufacture all our radiators to meet or even exceed Original Equipment specifications. We take pride in producing the most reliable replacement parts in the market.
  • We use longer header tabs for increased pressure resistance. This reduces the potential for tank to header leaks.
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Carquest Premium – Radiator: With Transmission Oil Cooler (Part No.434080)

Radiator: With Transmission Oil Cooler

from

$416.99
Carquest Premium Radiators offer one of the largest product ranges in the aftermarket, covering more than 95% of the popular automotive and light truck applications. Carquest Premium Radiators meet or exceed original equipment specifications, ensuring that products fit and perform just as well or better than the original parts, providing you peace of mind.

Product Features:
  • Our B-type tubes feature central reinforcement to provide greater tolerance to pressure. Stronger tube design means drastically reduced probability of tube failure.
  • Our deep extrusion header provides a stronger tube to header joint which is more resistant to the effects of vibration and thermal tube expansion, virtually eliminating tube to header leaks.
  • Our fin edges are folded for increased stability and heat disbursement properties.
  • Our included “multi-fit” attachments allow one radiator to cover multiple vehicle applications without sacrificing OE fit. This results in wider vehicle coverage with substantially less inventory.
  • Thermal expansion cuts allow for longer life and reduce failure rates by allowing improved core expansion and contraction during normal heat cycles.
  • We design and manufacture all our radiators to meet or even exceed Original Equipment specifications. We take pride in producing the most reliable replacement parts in the market.
  • We use longer header tabs for increased pressure resistance. This reduces the potential for tank to header leaks.
See More

Our Top-Rated Thermostat and Water Outlet Gaskets for 2001 Ford E-350 Super Duties

Make a smart move for your 2001 Ford E-350 Super Duty with our Thermostat and Water Outlet Gasket for $4.79.

Felpro – Engine Coolant Thermostat Housing Gasket (Part No.35702)

Engine Coolant Thermostat Housing Gasket

from

$4.79
Fel-Pro gaskets offer 100% vehicle sealing with application-specific materials to give you sealing solutions with the performance and durability professionals trust.

Product Features:
  • Meets or exceeds all original equipment specifications
  • Application specific design to ensure a perfect fit
  • Engineered and manufactured specifically for the repair environment
  • Unsurpassed quality you can trust
  • Validated for fit, form, and function
See More

Top-Rated Engine Cooling Part Brands For Your 2001 Ford E-350 Super Duty

When it comes to finding the perfect Engine Cooling Part for your 2001 Ford E-350 Super Duty, Advance Auto Parts has you covered with a wide selection of high-quality OEM and aftermarket options from 10 trusted brands. We carry the most popular Engine Cooling Part brands including Felpro, Carquest Premium, and Dorman, and more, all known for their exceptional customer ratings (average brand rating of 4.6 stars) and competitive prices, as low as $6.99. Purchasing a Engine Cooling Part from us here at Advance Auto Parts is a smart move for both you and your 2001 Ford E-350 Super Duty, providing peace of mind with parts that meet or exceed OEM standards.

Popular Felpro 2001 Ford E-350 Super Duty Engine Cooling Parts

If you’re looking for a top-quality Engine Cooling Part for your 2001 Ford E-350 Super Duty, Advance Auto Parts has exactly what you need with our selection of Felpro Engine Cooling Parts. We have 3 Felpro Engine Cooling Parts in stock for this fitment, all known for their durability and precision fit. With prices starting at just $6.99 and an average cost of $8.66, you’ll find the perfect Engine Cooling Part for your needs and budget. Felpro Engine Cooling Parts for the 2001 Ford E-350 Super Duty come highly rated, with over 6 customer reviews and an impressive average rating of 4.6 stars. Choosing a Felpro Engine Cooling Part from Advance Auto Parts is a smart move to ensure quality and value for your vehicle.
Engine Coolant Thermostat Housing Gasket
from $6.99
(4)
Engine Coolant Thermostat Housing Gasket
“Easy installation”
Engine Water Pump Gasket
from $10.99
(1)
Engine Water Pump Gasket
“Great rubber!”
Engine Water Pump Bypass Pipe O-Ring Kit
from $7.99
(1)
Engine Water Pump Bypass Pipe O-Ring Kit
“It was just what I needed”

Top-Quality Carquest Premium 2001 Ford E-350 Super Duty Engine Cooling Parts

For those in search of a high-quality Engine Cooling Part for their 2001 Ford E-350 Super Duty, Advance Auto Parts offers a great selection of Carquest Premium Engine Cooling Parts. With 3 Carquest Premium Engine Cooling Parts in stock, you can trust you’re getting top-tier parts designed for durability and a perfect fit. Prices for these Engine Cooling Parts start at just $14.99, with an average price of $15.99, giving you a range of options to suit your budget. Backed by over 88 customer ratings and an average rating of 4.4 stars, Carquest Premium Engine Cooling Parts provide both reliability and excellent performance. Choosing a Carquest Premium Engine Cooling Part from Advance Auto Parts is a smart investment in your vehicle’s performance and longevity.
High Flow Thermostat: 170 Degrees
from $14.99
(16)
High Flow Thermostat: 170 Degrees
“Great fit . Works properly so far so good”
Standard Thermostat: 195 Degrees
from $16.99
(56)
Standard Thermostat: 195 Degrees
“great”
Standard Thermostat: 180 Degrees
from $15.99
(16)
Standard Thermostat: 180 Degrees
“Car did not run hot, but lower radiator hose started leaking and was too hot to touch. Replaced and lower radiator hose temp was much cooler. Car runs”

FAQs for 2001 Ford E-350 Super Duty Engine Cooling Parts

What are the best-selling Engine Cooling Parts for 2001 Ford E-350 Super Duties?

Out of 63 Engine Cooling Parts that fit 2001 Ford E-350 Super Duties, the following parts are the top sellers:

What’s the price range for 2001 Ford E-350 Super Duty Engine Cooling Parts?

The prices of Engine Cooling Parts for the 2001 Ford E-350 Super Duty range from $4.79 up to $416.99 for the most premium parts.

What is the average price of an Engine Cooling Part for a 2001 Ford E-350 Super Duty?

The average price for Engine Cooling Parts for the 2001 Ford E-350 Super Duty is $80.72. Keep in mind the variety of part types within our Engine Cooling Part category, where you are likely to find a wide range of prices across a variety of parts and components.

Does Advance Auto Parts sell Engine Cooling Parts for other Ford E-350 Super Duty model years?

Yes, we carry Engine Cooling Parts for 24 model years of Ford E-350 Super Duties between 2000 and 2026. The following model years are the most popular for Engine Cooling Part purchases: 2022, 2021, 2019, 2018, 2017, 2016, 2015, 2014, and 2013.

What are the cheapest Engine Cooling Parts for my 2001 Ford E-350 Super Duty?

The cheapest 2001 Ford E-350 Super Duty Engine Cooling Parts we carry are:

Does Advance Auto Parts sell Engine Cooling Parts for any other 2001 Ford models?

What are the top-rated Engine Cooling Parts that fit the 2001 Ford E-350 Super Duty?

Based on 1,405 reviews by customers, our 2001 Ford E-350 Super Duty Engine Cooling Parts have an average customer rating of 4 stars. These are the highest-rated categories of Engine Cooling Parts for the 2001 Ford E-350 Super Duty and their top-rated products:

What types of Engine Cooling Parts do you sell for my 2001 Ford E-350 Super Duty?

As of 3/1/26, these are some of the most in-demand types of Engine Cooling Parts for a 2001 Ford E-350 Super Duty:

Can I get help with 2001 Ford E-350 Super Duty Engine Cooling Part orders?

Contact our customer support team by chat or phone, through the help desk page, where you can find instant answers about Ford Engine Cooling Parts and more.

What is your return policy for Ford E-350 Super Duty Engine Cooling Parts?

Advance Auto Parts keeps returns simple. For new Ford E-350 Super Duty Engine Cooling Parts and accessories, your online orders can be returned, in their original condition, within 45 days. For requirements, see the returns page.