GMC Sierra 2500 HD Differential Axle Shafts

Your GMC Sierra 2500 HD will be happy to know that the search for the right Differential Axle Shafts you’ve been looking for is over! Advance Auto Parts has 10 different Differential Axle Shafts for your vehicle, ready for shipping or in-store pick up. The best part is, our GMC Sierra 2500 HD Differential Axle Shafts start from as little as $232.99.

When it comes to your GMC Sierra 2500 HD, you want parts and products from only trusted brands. Here at Advance Auto Parts, we work with only top reliable Differential Axle Shafts brands so you can shop with complete confidence. Some of our top Differential Axle Shafts brands are Dorman and Yukon Gear. We’re sure you will get the right product to keep that Sierra 2500 HD running for a long time.

We even have reviews of our OEM and aftermarket Differential Axle Shafts products to help you buy with confidence. Hear from other customers via the 97 reviews on parts for your GMC Sierra 2500 HD.

Shop online, find the best price on the right product, and have it shipped right to your door. If you prefer to shop in person for the right Differential Axle Shafts for your Sierra 2500 HD, visit one of our local Advance Auto Parts locations and you’ll be back on the road in no time!

Compare 25 GMC Differential Axle Shafts

Dorman – Rear Axle Shaft, Left or Right (Part No.630-120)

Rear Axle Shaft, Left or Right

from

$285.99
Axle shaft damaged or bearings worn out? This axle shaft directly replaces the original equipment on certain vehicles, complete with all necessary application-specific installation components.

Product Features:
  • Direct replacement – this axle shaft replaces the original equipment on specific vehicle years, makes and models
  • Complete kit – each shaft includes critical installation hardware and components needed for specific vehicle applications
  • Durable construction – designed to rigorous standards and tested to ensure performance
  • Trustworthy solution – backed by team of engineers and quality control specialists in the United States
See More

Dorman – Rear Axle Shaft, Left or Right (Part No.630-111)

Rear Axle Shaft, Left or Right

from

$184.99
Axle shaft damaged or bearings worn out? This axle shaft directly replaces the original equipment on certain vehicles, complete with all necessary application-specific installation components.

Product Features:
  • Direct replacement – this axle shaft replaces the original equipment on specific vehicle years, makes and models
  • Complete kit – each shaft includes critical installation hardware and components needed for specific vehicle applications
  • Durable construction – designed to rigorous standards and tested to ensure performance
  • Trustworthy solution – backed by team of engineers and quality control specialists in the United States
See More

Motive Gear – Axle Shaft (Part No.12479285)

Axle Shaft

from

$119.99
The Motive Gear replacement axle shaft offers an OE-quality axle shaft at a fraction of the OE cost. Manufactured from 1541H material on high-tolerance CNC equipment, this axle shaft is designed to provide a perfect fit every time.

Product Features:
  • AXLE SHAFT GM8.6″ 30SPL. L/R 2/4WD 33 9/16″ O.A. 1999-2006
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Dorman – Rear Axle Shaft, Left or Right (Part No.630-146)

Rear Axle Shaft, Left or Right

from

$273.99
Axle shaft damaged or bearings worn out? This axle shaft directly replaces the original equipment on certain vehicles, complete with all necessary application-specific installation components.

Product Features:
  • Direct replacement – this axle shaft replaces the original equipment on specific vehicle years, makes and models
  • Complete kit – each shaft includes critical installation hardware and components needed for specific vehicle applications
  • Durable construction – designed to rigorous standards and tested to ensure performance
  • Trustworthy solution – backed by team of engineers and quality control specialists in the United States
See More

Pro-King – Rear Axle Shaft Kit (Part No.AXK-153)

Rear Axle Shaft Kit

from

$244.99
Pro-King is the leading supplier of transmission and driveline products in the aftermarket. All products are designed to meet or exceed OE quality, form, fit and funtion.

Product Features:
  • High strength steel
  • Dual heat treating process
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Motive Gear – Axle Shaft (Part No.26042818)

Axle Shaft

from

$161.99
Motive Gear offers some of the toughest drive train components on the market today. If you are looking for the largest line of performance ring and pinion gear options available with gear sets in a wide range of ratios for nearly every application, both o
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Motive Gear – Axle Shaft (Part No.26010416)

Axle Shaft

from

$149.99
The Motive Gear replacement axle shaft offers an OE-quality axle shaft at a fraction of the OE cost. Manufactured from 1541H material on high-tolerance CNC equipment, this axle shaft is designed to provide a perfect fit every time.

Product Features:
  • AXLE SHAFT 10 BOLT 4X4 ’88-98 33 1/8 OA – 30 SP 1/2 TON
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Motive Gear – Axle Shaft (Part No.26013313)

Axle Shaft

from

$124.99
This Motive Gear replacement axle shaft offers an OE-quality axle shaft at a fraction of the OE cost. Manufactured from 1541H material on high-tolerance CNC equipment, this axle shaft is designed to provide a perfect fit every time.

Product Features:
  • CNC-manufactured for exacting tolerances
  • Induction heat treating provides long life and wear resistance
  • AXLE SHAFT 88-95 GM VAN 33.31″ 30SP FULL SIZE 1/2 & 3/4 TON;L/R=8.5/8.6
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Dorman – Rear Axle Shaft, Left or Right (Part No.630-103)

Rear Axle Shaft, Left or Right

from

$195.99
Axle shaft damaged or bearings worn out? This axle shaft directly replaces the original equipment on certain vehicles, complete with all necessary application-specific installation components.

Product Features:
  • Direct replacement – this axle shaft replaces the original equipment on specific vehicle years, makes and models
  • Complete kit – each shaft includes critical installation hardware and components needed for specific vehicle applications
  • Durable construction – designed to rigorous standards and tested to ensure performance
  • Trustworthy solution – backed by team of engineers and quality control specialists in the United States
See More

Pro-King – Rear Axle Shaft Kit (Part No.AXK-166)

Rear Axle Shaft Kit

from

$137.99
Pro-King is the leading supplier of transmission and driveline products in the aftermarket. All products are designed to meet or exceed OE quality, form, fit and funtion.

Product Features:
  • High strength steel
  • Dual heat treating process
See More

Dorman – Rear Axle Shaft, Left or Right (Part No.630-102)

Rear Axle Shaft, Left or Right

from

$215.99
Axle shaft damaged or bearings worn out? This axle shaft directly replaces the original equipment on certain vehicles, complete with all necessary application-specific installation components.

Product Features:
  • Direct replacement – this axle shaft replaces the original equipment on specific vehicle years, makes and models
  • Complete kit – each shaft includes critical installation hardware and components needed for specific vehicle applications
  • Durable construction – designed to rigorous standards and tested to ensure performance
  • Trustworthy solution – backed by team of engineers and quality control specialists in the United States
See More

Dorman – Rear Axle Shaft, Left or Right (Part No.630-106)

Rear Axle Shaft, Left or Right

from

$201.99
Axle shaft damaged or bearings worn out? This axle shaft directly replaces the original equipment on certain vehicles, complete with all necessary application-specific installation components.

Product Features:
  • Direct replacement – this axle shaft replaces the original equipment on specific vehicle years, makes and models
  • Complete kit – each shaft includes critical installation hardware and components needed for specific vehicle applications
  • Durable construction – designed to rigorous standards and tested to ensure performance
  • Trustworthy solution – backed by team of engineers and quality control specialists in the United States
See More

Dorman – Rear Axle Shaft, Left or Right (Part No.630-121)

Rear Axle Shaft, Left or Right

from

$161.99
Axle shaft damaged or bearings worn out? This axle shaft directly replaces the original equipment on certain vehicles, complete with all necessary application-specific installation components.

Product Features:
  • Direct replacement – this axle shaft replaces the original equipment on specific vehicle years, makes and models
  • Complete kit – each shaft includes critical installation hardware and components needed for specific vehicle applications
  • Durable construction – designed to rigorous standards and tested to ensure performance
  • Trustworthy solution – backed by team of engineers and quality control specialists in the United States
See More

Dorman – GM 8.25 IFS Inner Axle Shaft (Part No.630-422)

GM 8.25 IFS Inner Axle Shaft

from

$173.99
Axle shaft damaged or bearings worn out? This axle shaft assembly directly replaces the original equipment on certain vehicles, ready for install right out of the box.

Product Features:
  • Direct replacement – this axle shaft assembly replaces the original equipment on specific vehicle years, makes and models
  • Ready to install – comes pre-assembled for simple installation with no further assembly required
  • Durable construction – designed to rigorous standards and tested to ensure performance
  • Trustworthy solution – backed by team of engineers and quality control specialists in the United States
See More

Dorman – Rear Axle Shaft, Left or Right (Part No.630-100)

Rear Axle Shaft, Left or Right

from

$156.99
Axle shaft damaged or bearings worn out? This axle shaft directly replaces the original equipment on certain vehicles, complete with all necessary application-specific installation components.

Product Features:
  • Direct replacement – this axle shaft replaces the original equipment on specific vehicle years, makes and models
  • Complete kit – each shaft includes critical installation hardware and components needed for specific vehicle applications
  • Durable construction – designed to rigorous standards and tested to ensure performance
  • Trustworthy solution – backed by team of engineers and quality control specialists in the United States
See More

Motive Gear – Axle Shaft (Part No.14035542)

Axle Shaft

from

$136.99
The Motive Gear replacement axle shaft offers an OE-quality axle shaft at a fraction of the OE cost. Manufactured from 1541H material on high-tolerance CNC equipment, this axle shaft is designed to provide a perfect fit every time.

Product Features:
  • AXLE SHAFT 8.5 2WD 28 SPL 31 1/2 OA EARLY 88 DOWN
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Motive Gear – Axle Shaft (Part No.14071751)

Axle Shaft

from

$129.99
The Motive Gear replacement axle shaft offers an OE-quality axle shaft at a fraction of the OE cost. Manufactured from 1541H material on high-tolerance CNC equipment, this axle shaft is designed to provide a perfect fit every time.

Product Features:
  • AXLE SHAFT 8 7/8 2 WD 31 1/4 TRK 30 SPL 5 LUG
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Yukon Gear – Axle For ’07 And Up 9.5" GM Axle, 34.02" (Part No.21586)

Axle For '07 And Up 9.5" GM Axle, 34.02"

from

$299.99
2007 and up 9.5″ GM axle, 34.02″. axle shaft for ’07 & up GM truck with 9.5″ differential, 34.02″ long, 6 lug. Yukon 1541H alloy axles offer a strength increase over stock while retaining a low cost. Yukon 1541H alloy front axles come with a one year warranty against manufacturing defects.

Product Features:
  • 33 spline
  • 34.02″ long
  • Fits GM 9.5″ in 2007 and up truck
See More

Dorman – Rear Axle Shaft – Right or Left Side (Part No.630-325)

Rear Axle Shaft - Right or Left Side

from

$386.99
Axle shaft damaged or bearings worn out? This axle shaft directly replaces the original equipment on certain vehicles, complete with all necessary application-specific installation components.

Product Features:
  • Direct replacement – this axle shaft replaces the original equipment on specific vehicle years, makes and models
  • Complete kit – each shaft includes critical installation hardware and components needed for specific vehicle applications
  • Durable construction – designed to rigorous standards and tested to ensure performance
  • Trustworthy solution – backed by team of engineers and quality control specialists in the United States
See More

Dorman – Rear Axle Shaft, Left or Right (Part No.630-145)

Rear Axle Shaft, Left or Right

from

$309.99
Axle shaft damaged or bearings worn out? This axle shaft directly replaces the original equipment on certain vehicles, complete with all necessary application-specific installation components.

Product Features:
  • Direct replacement – this axle shaft replaces the original equipment on specific vehicle years, makes and models
  • Complete kit – each shaft includes critical installation hardware and components needed for specific vehicle applications
  • Durable construction – designed to rigorous standards and tested to ensure performance
  • Trustworthy solution – backed by team of engineers and quality control specialists in the United States
See More

Dorman – General Motors Full Float Axle Shaft (Part No.630-147)

General Motors Full Float Axle Shaft

from

$243.99
Axle shaft damaged or bearings worn out? This axle shaft directly replaces the original equipment on certain vehicles, complete with all necessary application-specific installation components.

Product Features:
  • Direct replacement – this axle shaft replaces the original equipment on specific vehicle years, makes and models
  • Complete kit – each shaft includes critical installation hardware and components needed for specific vehicle applications
  • Durable construction – designed to rigorous standards and tested to ensure performance
  • Trustworthy solution – backed by team of engineers and quality control specialists in the United States
See More

USA Standard Gear – 4340 Chrome-Moly Replacement Inner Axle For ’77-’91 GM Dana 60, 35 Spline (Part No.35098)

4340 Chrome-Moly Replacement Inner Axle For '77-'91 GM Dana 60, 35 Spline

from

$203.99
Product Features:
  • Fits Dana Spicer 60 front in 1979-1991 GM and 1979-1990 Dodge trucks
  • 4340 Chromoly
  • Left hand inner axle
  • 35 spline
  • 17.67″ from end of splines to center of u-joint bore
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Dorman – Front Axle Shaft, GM 8.25IFS (Part No.630-420)

Front Axle Shaft, GM 8.25IFS

from

$303.99
Axle shaft damaged or bearings worn out? This axle shaft assembly directly replaces the original equipment on certain vehicles, ready for install right out of the box.

Product Features:
  • Direct replacement – this axle shaft assembly replaces the original equipment on specific vehicle years, makes and models
  • Ready to install – comes pre-assembled for simple installation with no further assembly required
  • Durable construction – designed to rigorous standards and tested to ensure performance
  • Trustworthy solution – backed by team of engineers and quality control specialists in the United States
See More

Motive Gear – Axle Shaft (Part No.MG1774)

Axle Shaft

from

$168.99
The Motive Gear replacement axle shaft offers an OE-quality axle shaft at a fraction of the OE cost. Manufactured from 1541H material on high-tolerance CNC equipment, this axle shaft is designed to provide a perfect fit every time.

Product Features:
  • AXLE SHAFT 10.5″ 30 SPL. 37 9/16″ R.H.
See More

Motive Gear – Axle Shaft (Part No.26050549)

Axle Shaft

from

$139.99
The Motive Gear replacement axle shaft offers an OE-quality axle shaft at a fraction of the OE cost. Manufactured from 1541H material on high-tolerance CNC equipment, this axle shaft is designed to provide a perfect fit every time.

Product Features:
  • AXLE SHAFT 98 SONOMA 4X4 DISK BRAKE ABS, 28 15/16 O.A. 7.6 28 SPLINE
See More

FAQs for GMC Sierra 2500 HD Differential Axle Shafts

What are the most popular Differential Axle Shafts for the GMC Sierra 2500 HD?

With 4 brands you can trust, our most popular Differential Axle Shafts for the GMC Sierra 2500 HD are:
Rear Axle Shaft, Left or Right
from $309.99
This product is not rated
Rear Axle Shaft, Left or Right
Differential Axle Shafts
Axle Shaft
from $256.99
This product is not rated
Axle Shaft
Differential Axle Shafts
Full-Floating, Blank 35 Spline Diameter, Non-Drilled Axle Shaft For Dana 60
from $232.99
This product is not rated
Full-Floating, Blank 35 Spline Diameter, Non-Drilled Axle Shaft For Dana 60
Differential Axle Shafts