GMC Sierra 2500 Climate Control Modules

Your GMC Sierra 2500 will be happy to know that the search for the right Climate Control Modules you’ve been looking for is over! Advance Auto Parts has 9 different Climate Control Modules for your vehicle, ready for shipping or in-store pick up. The best part is, our GMC Sierra 2500 Climate Control Modules start from as little as $216.99.

When it comes to your GMC Sierra 2500, you want parts and products from only trusted brands. Here at Advance Auto Parts, we work with only top reliable Climate Control Modules brands so you can shop with complete confidence. Some of our top Climate Control Modules brands are Dorman. We’re sure you will get the right product to keep that Sierra 2500 running for a long time.

We even have reviews of our OEM and aftermarket Climate Control Modules products to help you buy with confidence. Hear from other customers via the 71 reviews on parts for your GMC Sierra 2500.

Shop online, find the best price on the right product, and have it shipped right to your door. If you prefer to shop in person for the right Climate Control Modules for your Sierra 2500, visit one of our local Advance Auto Parts locations and you’ll be back on the road in no time!

Compare 25 GMC Climate Control Modules

Dorman – Remanufactured Climate Control Module (Part No.599-013)

Remanufactured Climate Control Module

from

$324.99
This replacement HVAC control module is specifically designed to provide optimal performance at a more affordable price than replacement at the dealer. It has undergone extensive testing to ensure proper function in specific vehicle applications.

Product Features:
  • Remanufactured Climate Control Module
  • Remanufactured Climate Control Module
  • This replacement HVAC control module is specifically designed to provide optimal performance at a more affordable price than replacement at the dealer. It has undergone extensive testing to ensure proper function in specific vehicle applications.
  • Direct replacement – this HVAC control module was specifically designed to match the performance of the original equipment
  • Functionality-tested – modules has been tested to ensure the same operation as the stock module
See More

Dorman – Remanufactured Climate Control Module (Part No.599-004)

Remanufactured Climate Control Module

from

$205.99
This replacement HVAC control module is specifically designed to provide optimal performance at a more affordable price than replacement at the dealer. It has undergone extensive testing to ensure proper function in specific vehicle applications.

Product Features:
  • Remanufactured Climate Control Module
  • Remanufactured Climate Control Module
  • This replacement HVAC control module is specifically designed to provide optimal performance at a more affordable price than replacement at the dealer. It has undergone extensive testing to ensure proper function in specific vehicle applications.
  • Direct replacement – this HVAC control module was specifically designed to match the performance of the original equipment
  • Functionality-tested – modules has been tested to ensure the same operation as the stock module
See More

Dorman – Remanufactured Climate Control Module (Part No.599-025)

Remanufactured Climate Control Module

from

$271.99
Climate controls stopped working? Seamlessly restore operation by easily swapping the malfunctioning original module with this fully tested replacement unit.

Product Features:
  • Remanufactured Climate Control Module
  • Remanufactured Climate Control Module
  • Climate controls stopped working? Seamlessly restore operation by easily swapping the malfunctioning original module with this fully tested replacement unit.
  • Direct replacement – this HVAC control module matches the appearance and function of the original unit on specific vehicles
  • Function tested – module has been tested to ensure the same operation as the stock module
See More

Dorman – Remanufactured Climate Control Module (Part No.599-001)

Remanufactured Climate Control Module

from

$241.99
This replacement HVAC control module is specifically designed to provide optimal performance at a more affordable price than replacement at the dealer. It has undergone extensive testing to ensure proper function in specific vehicle applications.

Product Features:
  • Remanufactured Climate Control Module
  • Remanufactured Climate Control Module
  • This replacement HVAC control module is specifically designed to provide optimal performance at a more affordable price than replacement at the dealer. It has undergone extensive testing to ensure proper function in specific vehicle applications.
  • Direct replacement – this HVAC control module was specifically designed to match the performance of the original equipment
  • Functionality-tested – modules has been tested to ensure the same operation as the stock module
See More

Dorman – Remanufactured Climate Control Module (Part No.599-009)

Remanufactured Climate Control Module

from

$296.99
This replacement HVAC control module is specifically designed to provide optimal performance at a more affordable price than replacement at the dealer. It has undergone extensive testing to ensure proper function in specific vehicle applications.

Product Features:
  • Remanufactured Climate Control Module
  • Remanufactured Climate Control Module
  • This replacement HVAC control module is specifically designed to provide optimal performance at a more affordable price than replacement at the dealer. It has undergone extensive testing to ensure proper function in specific vehicle applications.
  • Direct replacement – this HVAC control module was specifically designed to match the performance of the original equipment
  • Functionality-tested – modules has been tested to ensure the same operation as the stock module
See More

Dorman – Remanufactured Climate Control Module (Part No.599-266)

Remanufactured Climate Control Module

from

$234.99
Climate controls stopped working? Seamlessly restore operation by easily swapping the malfunctioning original module with this fully tested replacement unit.

Product Features:
  • Direct replacement – this HVAC control module matches the appearance and function of the original unit on specific vehicles
  • Functionality-tested – module has been tested to ensure the same operation as the stock module
  • Simple installation – no advanced vehicle knowledge is required for proper installation and setup
  • Trustworthy quality – backed by team of engineers and inspectors in the United States
See More

Dorman – Remanufactured Climate Control Module (Part No.599-003)

Remanufactured Climate Control Module

from

$282.99
This replacement HVAC control module is specifically designed to provide optimal performance at a more affordable price than replacement at the dealer. It has undergone extensive testing to ensure proper function in specific vehicle applications.

Product Features:
  • Remanufactured Climate Control Module
  • Remanufactured Climate Control Module
  • This replacement HVAC control module is specifically designed to provide optimal performance at a more affordable price than replacement at the dealer. It has undergone extensive testing to ensure proper function in specific vehicle applications.
  • Direct replacement – this HVAC control module was specifically designed to match the performance of the original equipment
  • Functionality-tested – modules has been tested to ensure the same operation as the stock module
See More

Dorman – Remanufactured Climate Control Module (Part No.599-260)

Remanufactured Climate Control Module

from

$372.99
This replacement HVAC control module is specifically designed to provide optimal performance at a more affordable price than replacement at the dealer. It has undergone extensive testing to ensure proper function in specific vehicle applications.

Product Features:
  • Remanufactured Climate Control Module
  • Remanufactured Climate Control Module
  • This replacement HVAC control module is specifically designed to provide optimal performance at a more affordable price than replacement at the dealer. It has undergone extensive testing to ensure proper function in specific vehicle applications.
  • Direct replacement – this HVAC control module was specifically designed to match the performance of the original equipment
  • Functionality-tested – modules has been tested to ensure the same operation as the stock module
See More

Dorman – Remanufactured Climate Control Module (Part No.599-261)

Remanufactured Climate Control Module

from

$132.99
Climate controls stopped working? Seamlessly restore operation by easily swapping the malfunctioning original module with this fully tested replacement unit.

Product Features:
  • Direct replacement – this HVAC control module matches the appearance and function of the original unit on specific vehicles
  • Functionality-tested – module has been tested to ensure the same operation as the stock module
  • Simple installation – no advanced vehicle knowledge is required for proper installation and setup
  • Trustworthy quality – backed by team of engineers and inspectors in the United States
See More

Dorman – Climate Control Module (Part No.599-007)

Climate Control Module

from

$255.99
Climate controls stopped working? Seamlessly restore operation by easily swapping the malfunctioning original module with this fully tested replacement unit.

Product Features:
  • Direct replacement – this module is designed to match the fit and function of an factory module on specified General Motors pickup trucks and SUVs that were not originally equipped with a rear window defroster feature
  • Leading-edge technology – assembled in our sophisticated electronics manufacturing facility in Lewisberry, Pennsylvania, using the most advanced processes and testing
  • All-new construction – engineered with quality components and thoroughly validated to restore the same functions as the factory module
  • Trustworthy quality – backed by team of product experts in the United States and more than a century of automotive experience
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Dorman – HVAC Control Module (Part No.601-036)

HVAC Control Module

from

$156.99
Climate controls stopped working? Seamlessly restore operation by easily swapping the malfunctioning original module with this fully tested replacement unit.

Product Features:
  • Direct replacement – this HVAC control module matches the appearance and function of the original unit on specific vehicles
  • Functionality-tested – module has been tested to ensure the same operation as the stock module
  • Simple installation – no advanced vehicle knowledge is required for proper installation and setup
  • Trustworthy quality – backed by team of engineers and inspectors in the United States
See More

Dorman – Climate Control Module (Part No.599-006)

Climate Control Module

from

$208.99
Climate controls stopped working? Seamlessly restore operation by easily swapping the malfunctioning original module with this fully tested replacement unit.

Product Features:
  • Direct replacement – this module is designed to match the fit and function of an original module on specified General Motors pickup trucks and SUVs with a factory-installed rear window defroster feature
  • Leading-edge technology – assembled in our IATF-certified electronics manufacturing facility in Lewisberry, Pennsylvania, using the most advanced processes and testing
  • All-new construction – engineered with quality components and thoroughly validated to restore the same functions as the factory module
  • Trustworthy quality – backed by team of product experts in the United States and more than a century of automotive experience
See More

Dorman – Climate Control Module (Part No.599-218)

Climate Control Module

from

$216.99
Climate controls stopped working? Seamlessly restore operation by easily swapping the malfunctioning original module with this fully tested replacement unit.

Product Features:
  • Direct replacement – this HVAC control module matches the appearance and function of the original unit on specific vehicles
  • Functionality-tested – module has been tested to ensure the same operation as the stock module
  • Simple installation – no advanced vehicle knowledge is required for proper installation and setup
  • Trustworthy quality – backed by team of engineers and inspectors in the United States
See More

Dorman – Climate Control Module (Part No.599-217)

Climate Control Module

from

$249.99
Climate controls stopped working in your Chevy Express or GMC Savana van? This brand new direct replacement restores performance and maintains the original look and feel of certain model years, for a seamless, reliable repair.

Product Features:
  • Direct replacement – this HVAC control module is specially designed to match the appearance and function of the original unit in select vehicles
  • Plug-and-play installation – just remove the old module, plug in new module, and vehicle performs automatic recalibration
  • Design options – module comes with both older and newer knob designs so you can pick your preference
  • 100% new – module is newly manufactured, not remanufactured, with state-of-the-art components
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Dorman – Climate Control Module (Part No.599-211XD)

Climate Control Module

from

$269.99
Climate controls stopped working? Easily replace your unit with this brand new Dorman OE FIX HVAC control module assembled and tested in the USA. This unit contains proprietary software that eliminates the need for programming with GM-specific software like SPS (Service Programming System). Because of this, one OE FIX module fits a wide range of General Motors, Isuzu and Saab vehicles that have automatic air conditioning controls. After installation, the unit is automatically configured to the vehicle, making installation quick and easy.

Product Features:
  • Easy installation – this climate control module features unique software that automatically configures the unit to the vehicle as soon as you plug it in, requiring no manual setup
  • Assembled in America – this 100% new unit is finished and tested at an advanced facility in Pennsylvania to ensure stringent quality control
  • Restores functionality – unit restores primary operations of original equipment (control functions on some models may vary from original)
  • Seamless fit – unit is identical in appearance to the factory module, retaining original look and feel
See More

Dorman – Climate Control Module (Part No.599-210XD)

Climate Control Module

from

$233.99
Climate controls stopped working? Easily replace your unit with this brand new Dorman OE FIX HVAC control module assembled and tested in the USA. This unit contains proprietary software that eliminates the need for programming with GM-specific software like SPS (Service Programming System). Because of this, one OE FIX module fits a wide range of General Motors, Isuzu and Saab vehicles that have manual air conditioning controls. After installation, the unit is automatically configured to the vehicle, making installation quick and easy.

Product Features:
  • Easy installation – this climate control module features unique software that automatically configures the unit to the vehicle as soon as you plug it in, requiring no manual setup
  • Assembled in America – this 100% new unit is finished and tested at an advanced facility in Pennsylvania to ensure stringent quality control
  • Restores functionality – unit restores primary operations of original equipment (control functions on some models may vary from original)
  • Seamless fit – unit is identical in appearance to the factory module, retaining original look and feel
See More

Dorman – Remanufactured Climate Control Module (Part No.599-138)

Remanufactured Climate Control Module

from

$309.99
Affordable and a proper fit – our remanufactured Climate Control Module offers all this and more. A direct replacement, our renewed module will blend in with the interior design of your vehicle.

Product Features:
  • Remanufactured Climate Control Module
  • Remanufactured Climate Control Module
  • Affordable and a proper fit – our remanufactured Climate Control Module offers all this and more. A direct replacement, our renewed module will blend in with the interior design of your vehicle.
  • 100% replacement of backlight bulbs
  • 100% O-Ring replacement (where applicable)
See More

Dorman – Remanufactured Climate Control Module (Part No.599-020)

Remanufactured Climate Control Module

from

$321.99
Climate controls stopped working? Seamlessly restore operation by easily swapping the malfunctioning original module with this fully tested replacement unit.

Product Features:
  • Remanufactured Climate Control Module
  • Remanufactured Climate Control Module
  • Climate controls stopped working? Seamlessly restore operation by easily swapping the malfunctioning original module with this fully tested replacement unit.
  • Direct replacement – this HVAC control module matches the appearance and function of the original unit on specific vehicles
  • Function tested – module has been tested to ensure the same operation as the stock module
See More

Dorman – Remanufactured Climate Control Module (Part No.599-018)

Remanufactured Climate Control Module

from

$297.99
Climate controls stopped working? Seamlessly restore operation by easily swapping the malfunctioning original module with this fully tested replacement unit.

Product Features:
  • Remanufactured Climate Control Module
  • Remanufactured Climate Control Module
  • Climate controls stopped working? Seamlessly restore operation by easily swapping the malfunctioning original module with this fully tested replacement unit.
  • Direct replacement – this HVAC control module matches the appearance and function of the original unit on specific vehicles
  • Function tested – module has been tested to ensure the same operation as the stock module
See More

Dorman – Climate Control Module (Part No.599-215)

Climate Control Module

from

$556.99
Climate controls stopped working? Seamlessly restore operation by easily swapping the malfunctioning original module with this fully tested replacement unit.

Product Features:
  • Direct replacement – this HVAC control module matches the appearance and function of the original unit on specific vehicles
  • Functionality-tested – module has been tested to ensure the same operation as the stock module
  • Simple installation – no advanced vehicle knowledge is required for proper installation and setup
  • Trustworthy quality – backed by team of engineers and inspectors in the United States
See More

Dorman – Remanufactured Climate Control Module (Part No.599-017)

Remanufactured Climate Control Module

from

$453.99
Climate controls stopped working? Seamlessly restore operation by easily swapping the malfunctioning original module with this fully tested replacement unit.

Product Features:
  • Remanufactured Climate Control Module
  • Remanufactured Climate Control Module
  • Climate controls stopped working? Seamlessly restore operation by easily swapping the malfunctioning original module with this fully tested replacement unit.
  • Direct replacement – this HVAC control module matches the appearance and function of the original unit on specific vehicles
  • Function tested – module has been tested to ensure the same operation as the stock module
See More

Dorman – Remanufactured Climate Control Module (Part No.599-019)

Remanufactured Climate Control Module

from

$432.99
Climate controls stopped working? Seamlessly restore operation by easily swapping the malfunctioning original module with this fully tested replacement unit.

Product Features:
  • Direct replacement – this HVAC control module matches the appearance and function of the original unit on specific vehicles
  • Function tested – module has been tested to ensure the same operation as the stock module
  • Simple installation – advanced vehicle knowledge is not required for proper installation
  • Trustworthy quality – backed by team of engineers and inspectors in the United States
See More

Dorman – Remanufactured Climate Control Module (Part No.599-190)

Remanufactured Climate Control Module

from

$369.99
Affordable, a proper fit, and optimal performance – our remanufactured HVAC control module offers all this and more. A direct replacement, our cosmetically renewed module will blend in with the overall interior design of your vehicle.

Product Features:
  • Remanufactured Climate Control Module
  • Remanufactured Climate Control Module
  • Affordable, a proper fit, and optimal performance – our remanufactured HVAC control module offers all this and more. A direct replacement, our cosmetically renewed module will blend in with the overall interior design of your vehicle.
  • 100% replacement of backlight bulbs
  • High-quality replacement and renewed parts ensure long-lasting service
See More

GM Genuine Parts – Heater, Air Conditioning, and Radio Control Module (Part No.15881861)

Heater, Air Conditioning, and Radio Control Module

from

$338.99
GM Genuine Parts HVAC Control Modules are designed, engineered, and tested to rigorous standards, and are backed by General Motors. These HVAC control modules manage the temperature, air distribution, blower fan, and air conditioning functions in automatic climate control systems. In certain applications, the control module may encompass the control panel. GM Genuine Parts are the true OE parts installed during the production of or validated by General Motors for GM vehicles. Some GM Genuine Parts may have formerly appeared as ACDelco GM Original Equipment (OE).

Product Features:
  • This part requires programming and/or special setup procedures. GM Service Information describes the procedures and special tools needed to ensure proper operation in the vehicle
  • Enables you to control climate control settings
  • Some GM Genuine Parts may have formerly appeared as ACDelco GM Original Equipment (OE)
  • GM Genuine Parts are designed, engineered and tested to rigorous standards, and are backed by General Motors
  • GM Engineers design and validate OE parts specifically for your Chevrolet, Buick, GMC, or Cadillac vehicle
  • GM regularly updates production and service part designs to integrate new materials and technologies
See More

Dorman – Remanufactured Climate Control Module (Part No.599-142)

Remanufactured Climate Control Module

from

$305.99
Affordable, a proper fit, and optimal performance – our remanufactured HVAC control module offers all this and more. A direct replacement, our cosmetically renewed module will blend in with the overall interior design of your vehicle.

Product Features:
  • Remanufactured Climate Control Module
  • Remanufactured Climate Control Module
  • Affordable, a proper fit, and optimal performance – our remanufactured HVAC control module offers all this and more. A direct replacement, our cosmetically renewed module will blend in with the overall interior design of your vehicle.
  • 100% replacement of backlight bulbs
  • High-quality replacement and renewed parts ensure long-lasting service
See More

FAQs for GMC Sierra 2500 Climate Control Modules

What are the most popular Climate Control Modules for the GMC Sierra 2500?

With 1 brands you can trust, our most popular Climate Control Modules for the GMC Sierra 2500 are:
Remanufactured Climate Control Module
from $241.99
(12)
Remanufactured Climate Control Module
Climate Control Modules
Remanufactured Climate Control Module
from $296.99
(10)
Remanufactured Climate Control Module
Climate Control Modules
Remanufactured Climate Control Module
from $234.99
(4)
Remanufactured Climate Control Module
Climate Control Modules

What are the best aftermarket Climate Control Modules for the GMC Sierra 2500?

See what past customers had to say about our highest-rated Climate Control Modules for the GMC Sierra 2500:
Remanufactured Climate Control Module
from $372.99
(1)
Remanufactured Climate Control Module
“I purchased the Dorman Climate Control Module part # 599-260 to install in my 2002 GMC Yukon. Although I knew going in that this mart is “remanufactur”