GMC C25/C2500 Pickup Cylinder Heads

Your GMC C25/C2500 Pickup will be happy to know that the search for the right Cylinder Heads you’ve been looking for is over! Advance Auto Parts has 20 different Cylinder Heads for your vehicle, ready for shipping or in-store pick up. The best part is, our GMC C25/C2500 Pickup Cylinder Heads start from as little as $341.99.

When it comes to your GMC C25/C2500 Pickup, you want parts and products from only trusted brands. Here at Advance Auto Parts, we work with only top reliable Cylinder Heads brands so you can shop with complete confidence. Some of our top Cylinder Heads brands are Edelbrock and Spartan. We’re sure you will get the right product to keep that C25/C2500 Pickup running for a long time.

We even have reviews of our OEM and aftermarket Cylinder Heads products to help you buy with confidence. Hear from other customers via the 164 reviews on parts for your GMC C25/C2500 Pickup.

Shop online, find the best price on the right product, and have it shipped right to your door. If you prefer to shop in person for the right Cylinder Heads for your C25/C2500 Pickup, visit one of our local Advance Auto Parts locations and you’ll be back on the road in no time!

Compare 25 GMC Cylinder Heads

Edelbrock – RPM Small-Block Chevy Cylinder Head SBC 70cc Hydraulic Flat Tappet Cam (Part No.60739)

RPM Small-Block Chevy Cylinder Head SBC 70cc Hydraulic Flat Tappet Cam

from

$990.99
Product Features:
  • Out-of-the-Box Bolt-On Performance
  • With Straight Plugs
  • 70cc Combustion Chambers Improve Performance
  • Retain Stock Compression Ratio
See More

Edelbrock – E-Tec-200 Small-Block Chevy Cylinder Head Hydraulic Flat Tappet Cam (Part No.60989)

E-Tec-200 Small-Block Chevy Cylinder Head Hydraulic Flat Tappet Cam

from

$891.99
Product Features:
  • 64cc combustion chamber with 200cc intake runner
  • 2.02 in. intake and 1.60 in. exhaust valves
  • Flat Tappet Camshaft Type
  • Exhaust And Intake 45 Degree Seat Angle
  • Sold as one complete head
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Spartan – Engine Cylinder Head; Chev 2.4 11-13 Cyl Head (Part No.2CEW)

Engine Cylinder Head; Chev 2.4 11-13 Cyl Head

from

$755.99
Remanufactured Cylinder Heads are complete rebuild & include new valve stem seals, soft plugs & verified camshafts. All threads are checked and repaired if necessary. Cylinder Heads are packaged in heavy plastic to protect the unit.

Product Features:
  • All cylinder heads are both vacuum and pressure tested to verify valve seating, & integrity of water passages.
  • All cylinder heads are packaged in environmentally safe and recyclable containers that are the perfect size for returning your original core
  • All threads and machined surfaces are and repaired with technology that exceeds the original metal
  • Non-sealing iron surfaces painted to prevent oxidization
See More

Edelbrock – Small-Block Chevy E-Series Cylinder Head E-210 Flat Tappet Camshaft (Part No.5085)

Small-Block Chevy E-Series Cylinder Head E-210 Flat Tappet Camshaft

from

$1575.99
The Edelbrock #5085 E-210 Cylinder heads are designed for use with 1955-1986 Small-Block Chevy applications. The Edelbrock E-Series cylinder heads are a step up in affordable performance from our E-Street line. They feature larger runners for increased ai

Product Features:
  • Complete Pair For Hydraulic Flat Tappet
  • 64cc Combustion Chamber Volume
  • 210cc Intake/75cc Exhaust Runner Volume
  • 2.08 in. Intake/1.6 in. Exhaust Valve Diameter
  • 0.562 in. Deck Thickness
See More

Edelbrock – Small-Block Chevy E-Series Cylinder Head E-210 Hydraulic Roller Cam (Part No.5087)

Small-Block Chevy E-Series Cylinder Head E-210 Hydraulic Roller Cam

from

$1575.99
The Edelbrock #5087 E-210 Cylinder heads are designed for use with 1955-1986 Small-Block Chevy applications. The Edelbrock E-Series cylinder heads are a step up in affordable performance from our E-Street line. They feature larger runners for increased ai

Product Features:
  • Complete Pair For Mechanical Flat Tappet
  • 64cc Combustion Chamber Volume
  • 210cc Intake/75cc Exhaust Runner Volume
  • 2.08 in. Intake/1.6 in. Exhaust Valve Diameter
  • 0.562 in. Deck Thickness
See More

Edelbrock – E-Street Big-Block ChevyHead Cylinder Head Oval COMPLETE Single (Part No.50459)

E-Street Big-Block ChevyHead Cylinder Head Oval COMPLETE Single

from

$1279.99
The Edelbrock #50459 E-Street cylinder 290 Oval Port head is designed for Big-Block applications. The Edelbrock E-Street cylinder head offers American made quality and affordable performance. E-Street cylinder head features as-cast ports and are designed

Product Features:
  • Oval Port Complete Single For Hydraulic Flat Tappet
  • 110cc Combustion Chamber Volume
  • 220cc Intake/110cc Exhaust Runner Volume
  • 2.19 in. Intake/1.88 in. Exhaust Valve Diameter
  • 0.562 in. Deck Thickness
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Edelbrock – Small-Block Chevy E-Street Cylinder Head 70cc Pair (Part No.5073)

Small-Block Chevy E-Street Cylinder Head 70cc Pair

from

$1268.99
The Edelbrock #5073 E-Street cylinder heads are designed for use with 1955-1986 Small-Block Chevy applications. The Edelbrock E-Street cylinder heads offer American made quality and affordable performance. E-Street cylinder heads feature as-cast ports and

Product Features:
  • Complete Pair For Hydraulic Flat Tappet
  • 70cc Combustion Chamber Volume
  • 2.02cc Intake/60cc Exhaust Runner Volume
  • 2.02 in. Intake/1.6 in. Exhaust Valve Diameter
  • 0.562 in. Deck Thickness
See More

Edelbrock – Small-Block Chevy E-Street Cylinder Heads 64cc (Part No.5089)

Small-Block Chevy E-Street Cylinder Heads 64cc

from

$1229.99
The Edelbrock #5089 E-Street cylinder heads are designed for use with 1955-1986 Small-Block Chevy applications. The Edelbrock E-Street cylinder heads offer American made quality and affordable performance. E-Street cylinder heads feature as-cast ports and

Product Features:
  • Complete Pair For Hydraulic Flat Tappet
  • 64cc Combustion Chamber Volume
  • 2.02cc Intake/60cc Exhaust Runner Volume
  • 2.02 in. Intake/1.6 in. Exhaust Valve Diameter
  • 0.562 in. Deck Thickness
See More

Edelbrock – RPM Big-Block Chevy Rectangular Port Cylinder Head Hydraulic Roller Cam (Part No.60555)

RPM Big-Block Chevy Rectangular Port Cylinder Head Hydraulic Roller Cam

from

$1216.99
The Edelbrock #60555 Performer RPM Rectangle Port cylinder head is designed for Big-Block Chevy applications. The Edelbrock #60555 Performer RPM head is perfect for street performance, daily drivers, street rods and muscle cars where seat-of-the-pants per

Product Features:
  • Complete Single For Hydraulic Roller
  • 118cc Combustion Chamber Volume
  • 315cc Intake/110cc Exhaust Runner Volume
  • 2.19 in. Intake/1.88 in. Exhaust Valve Diameter
  • 0.562 in. Deck Thickness
See More

Edelbrock – RPM Small-Block Chevy Cylinder Head 64cc Hydraulic Flat Tappet Cam (Part No.60899)

RPM Small-Block Chevy Cylinder Head 64cc Hydraulic Flat Tappet Cam

from

$1192.99
Product Features:
  • Out-of-the-Box Bolt-On Performance
  • With Straight Plugs
  • 64cc Combustion Chambers Improve Performance
  • Retain Stock Compression Ratio
See More

Edelbrock – Performer Big-Block Chevy Oval Port Hydraulic Flat Tappet Cam (Part No.60499)

Performer Big-Block Chevy Oval Port Hydraulic Flat Tappet Cam

from

$1191.99
Product Features:
  • Complete Single For Flat Tappet
  • 100cc Combustion Chamber Volume
  • 290cc Intake/110cc Exhaust Runner Volume
  • 2.19 in. Intake/1.88 in. Exhaust Valve Diameter
  • 0.562 in. Deck Thickness
See More

Spartan – Engine Cylinder Head; Chev 6.6 DRMX Head (Part No.2CFM)

Engine Cylinder Head; Chev 6.6 DRMX Head

from

$1183.99
Remanufactured Cylinder Heads are complete rebuild & include new valve stem seals, soft plugs & verified camshafts. All threads are checked and repaired if necessary. Cylinder Heads are packaged in heavy plastic to protect the unit.

Product Features:
  • All cylinder heads are both vacuum and pressure tested to verify valve seating, & integrity of water passages.
  • All cylinder heads are packaged in environmentally safe and recyclable containers that are the perfect size for returning your original core
  • All threads and machined surfaces are and repaired with technology that exceeds the original metal
  • Non-sealing iron surfaces painted to prevent oxidization
See More

Edelbrock – RPM Big-Block Chevy Rectangular Port Cylinder Head Flat Tappet Cam (Part No.60559)

RPM Big-Block Chevy Rectangular Port Cylinder Head Flat Tappet Cam

from

$1180.99
Product Features:
  • Out-of-the-Box Bolt-On Performance
  • Designed For Street/High Performance Big Blocks
  • Specially Designed Ports
  • Increased Flow And Velocity
  • Highly Efficient Open Style Chamber
  • High Velocity Short Intake Ports
  • Rectangular Intake Ports
See More

Edelbrock – RPM Big-Block Chevy Oval Port Cylinder Head Hydraulic Flat Tappet Cam (Part No.60439)

RPM Big-Block Chevy Oval Port Cylinder Head Hydraulic Flat Tappet Cam

from

$1156.99
The Edelbrock #60439 Performer RPM High-Compression O-Port cylinder head is designed for Big-Block Chevy applications. The Edelbrock #60439 Performer RPM head is perfect for street performance, daily drivers, street rods and muscle cars where seat-of-the-

Product Features:
  • Complete Single High Compression 454-0
  • 100cc Combustion Chamber Volume
  • 290cc Intake/110cc Exhaust Runner Volume
  • 2.19 in. Intake/1.88 in. Exhaust Valve Diameter
  • 0.562 in. Deck Thickness
See More

Spartan – Engine Cylinder Head; Chev 6.6 04-09 DISEL Head (Part No.2CX6)

Engine Cylinder Head; Chev 6.6 04-09 DISEL Head

from

$1150.99
Remanufactured Cylinder Heads are complete rebuild & include new valve stem seals, soft plugs & verified camshafts. All threads are checked and repaired if necessary. Cylinder Heads are packaged in heavy plastic to protect the unit.

Product Features:
  • All cylinder heads are both vacuum and pressure tested to verify valve seating, & integrity of water passages.
  • All cylinder heads are packaged in environmentally safe and recyclable containers that are the perfect size for returning your original core
  • All threads and machined surfaces are and repaired with technology that exceeds the original metal
  • Non-sealing iron surfaces painted to prevent oxidization
See More

Spartan – Engine Cylinder Head; Chev 6.6 06-10 DRMX Head (Part No.2CX7)

Engine Cylinder Head; Chev 6.6 06-10 DRMX Head

from

$1134.99
Remanufactured Cylinder Heads are complete rebuild & include new valve stem seals, soft plugs & verified camshafts. All threads are checked and repaired if necessary. Cylinder Heads are packaged in heavy plastic to protect the unit.

Product Features:
  • All cylinder heads are both vacuum and pressure tested to verify valve seating, & integrity of water passages.
  • All cylinder heads are packaged in environmentally safe and recyclable containers that are the perfect size for returning your original core
  • All threads and machined surfaces are and repaired with technology that exceeds the original metal
  • Non-sealing iron surfaces painted to prevent oxidization
See More

Spartan – Engine Cylinder Head; Chev 6.6 10-16 Duramx Head (Part No.2CX10)

Engine Cylinder Head; Chev 6.6 10-16 Duramx Head

from

$1125.99
Remanufactured Cylinder Heads are complete rebuild & include new valve stem seals, soft plugs & verified camshafts. All threads are checked and repaired if necessary. Cylinder Heads are packaged in heavy plastic to protect the unit.

Product Features:
  • All cylinder heads are both vacuum and pressure tested to verify valve seating, & integrity of water passages.
  • All cylinder heads are packaged in environmentally safe and recyclable containers that are the perfect size for returning your original core
  • All threads and machined surfaces are and repaired with technology that exceeds the original metal
  • Non-sealing iron surfaces painted to prevent oxidization
See More

Edelbrock – RPM Small-Block Chevy Cylinder Head SBC 70cc Hydraulic Flat Tappet Cam (Part No.60759)

RPM Small-Block Chevy Cylinder Head SBC 70cc Hydraulic Flat Tappet Cam

from

$1014.99
Product Features:
  • 50-State Street Legal Aluminum Cylinder Head
  • Out-of-the-Box Bolt-On Performance
  • 70cc Combustion Chambers Improve Performance
  • Retain Stock Compression Ratio
See More

Spartan – Engine Cylinder Head; GM 6.0/6.2 10-19 CNG Head (Part No.2CT13CNG)

Engine Cylinder Head; GM 6.0/6.2 10-19 CNG Head

from

$986.99
Remanufactured Cylinder Heads are complete rebuild & include new valve stem seals, soft plugs & verified camshafts. All threads are checked and repaired if necessary. Cylinder Heads are packaged in heavy plastic to protect the unit.

Product Features:
  • All cylinder heads are both vacuum and pressure tested to verify valve seating, & integrity of water passages.
  • All cylinder heads are packaged in environmentally safe and recyclable containers that are the perfect size for returning your original core
  • All threads and machined surfaces are and repaired with technology that exceeds the original metal
  • Non-sealing iron surfaces painted to prevent oxidization
See More

Spartan – Engine Cylinder Head; Chev 6.6 10-16 Duramx Head (Part No.2CX11)

Engine Cylinder Head; Chev 6.6 10-16 Duramx Head

from

$956.99
Remanufactured Cylinder Heads are complete rebuild & include new valve stem seals, soft plugs & verified camshafts. All threads are checked and repaired if necessary. Cylinder Heads are packaged in heavy plastic to protect the unit.

Product Features:
  • All cylinder heads are both vacuum and pressure tested to verify valve seating, & integrity of water passages.
  • All cylinder heads are packaged in environmentally safe and recyclable containers that are the perfect size for returning your original core
  • All threads and machined surfaces are and repaired with technology that exceeds the original metal
  • Non-sealing iron surfaces painted to prevent oxidization
See More

Spartan – Engine Cylinder Head; Chev 6.5 92-00 Cyl Head (Part No.2CE2)

Engine Cylinder Head; Chev 6.5 92-00 Cyl Head

from

$945.99
Remanufactured Cylinder Heads are complete rebuild & include new valve stem seals, soft plugs & verified camshafts. All threads are checked and repaired if necessary. Cylinder Heads are packaged in heavy plastic to protect the unit.

Product Features:
  • All cylinder heads are both vacuum and pressure tested to verify valve seating, & integrity of water passages.
  • All cylinder heads are packaged in environmentally safe and recyclable containers that are the perfect size for returning your original core
  • All threads and machined surfaces are and repaired with technology that exceeds the original metal
  • Non-sealing iron surfaces painted to prevent oxidization
See More

Spartan – Engine Cylinder Head; Chev 6.6 DRMX Head (Part No.2CFN)

Engine Cylinder Head; Chev 6.6 DRMX Head

from

$920.99
Remanufactured Cylinder Heads are complete rebuild & include new valve stem seals, soft plugs & verified camshafts. All threads are checked and repaired if necessary. Cylinder Heads are packaged in heavy plastic to protect the unit.

Product Features:
  • All cylinder heads are both vacuum and pressure tested to verify valve seating, & integrity of water passages.
  • All cylinder heads are packaged in environmentally safe and recyclable containers that are the perfect size for returning your original core
  • All threads and machined surfaces are and repaired with technology that exceeds the original metal
  • Non-sealing iron surfaces painted to prevent oxidization
See More

Edelbrock – E-CNC Small-Block Chevy 64cc Cylinder Head Hydraulic Flat Tappet Cam (Part No.79899)

E-CNC Small-Block Chevy 64cc Cylinder Head Hydraulic Flat Tappet Cam

from

$873.99
The Edelbrock part #79899 Small Block Chevy E-CNC cylinder heads offer the ultimate performance. These cylinder heads are fully CNC ported for maximum horsepower and torque, making them ideal for high-performance’s street and racing applications. They als

Product Features:
  • Complete Single For Hydraulic Flat Tappet
  • 64cc Combustion Chamber Volume
  • 185cc Intake/75cc Exhaust Runner Volume
  • 2.02 in. Intake/1.6 in. Exhaust Valve Diameter
  • 0.562 in. Deck Thickness
See More

Spartan – Engine Cylinder Head; Chev 2.0 13-15 LTG Head (Part No.2CAD)

Engine Cylinder Head; Chev 2.0 13-15 LTG Head

from

$868.99
Remanufactured Cylinder Heads are complete rebuild & include new valve stem seals, soft plugs & verified camshafts. All threads are checked and repaired if necessary. Cylinder Heads are packaged in heavy plastic to protect the unit.

Product Features:
  • All cylinder heads are both vacuum and pressure tested to verify valve seating, & integrity of water passages.
  • All cylinder heads are packaged in environmentally safe and recyclable containers that are the perfect size for returning your original core
  • All threads and machined surfaces are and repaired with technology that exceeds the original metal
  • Non-sealing iron surfaces painted to prevent oxidization
See More

Spartan – Engine Cylinder Head; Chev 2.9L 07-11 Cyl Head (Part No.2CT29)

Engine Cylinder Head; Chev 2.9L 07-11 Cyl Head

from

$856.99
Remanufactured Cylinder Heads are complete rebuild & include new valve stem seals, soft plugs & verified camshafts. All threads are checked and repaired if necessary. Cylinder Heads are packaged in heavy plastic to protect the unit.

Product Features:
  • All cylinder heads are both vacuum and pressure tested to verify valve seating, & integrity of water passages.
  • All cylinder heads are packaged in environmentally safe and recyclable containers that are the perfect size for returning your original core
  • All threads and machined surfaces are and repaired with technology that exceeds the original metal
  • Non-sealing iron surfaces painted to prevent oxidization
See More

FAQs for GMC C25/C2500 Pickup Cylinder Heads

What are the most popular Cylinder Heads for the GMC C25/C2500 Pickup?

With 2 brands you can trust, our most popular Cylinder Heads for the GMC C25/C2500 Pickup are:
Small-Block Chevy E-Series Cylinder Head E-210 Hydraulic Roller Cam
from $1575.99
This product is not rated
Small-Block Chevy E-Series Cylinder Head E-210 Hydraulic Roller Cam
Cylinder Heads
Small-Block Chevy E-Street Cylinder Heads 64cc
from $1229.99
This product is not rated
Small-Block Chevy E-Street Cylinder Heads 64cc
Cylinder Heads
RPM Big-Block Chevy Rectangular Port Cylinder Head Hydraulic Roller Cam
from $1216.99
This product is not rated
RPM Big-Block Chevy Rectangular Port Cylinder Head Hydraulic Roller Cam
Cylinder Heads