2022 Lexus RX350 Engine Oils

Enhance and Protect Your 2022 Lexus RX350 with Quality Engine Oils

Maintaining the performance of your 2022 Lexus RX350 starts with choosing the right parts, and high-quality Engine Oil help ensure a reliable and efficient vehicle. At Advance Auto Parts, we offer Engine Oils specifically for the 2022 Lexus RX350, ensuring a perfect fit and lasting durability. Choosing to shop with Advance Auto Parts means you’re making a smart decision to prioritize both quality and reliability for your vehicle.

Affordable and Reliable Engine Oils for Every Budget

Finding affordable, quality Engine Oil is easy at Advance Auto Parts. With prices starting as low as $7.49 and an average price of $34.30, you can choose one that fits your budget while delivering the quality you expect. Our Engine Oils are competitively priced, ranging from $7.49 to $134.99, so you get value without compromising on strength or reliability.

Engine Oils for Your 2022 Lexus RX350

Castrol – Edge 0W-20 Full Synthetic Motor Oil, Superior Wear Protection, 5 Quart (Part No.1597B2)

Edge 0W-20 Full Synthetic Motor Oil, Superior Wear Protection, 5 Quart

from

$37.99
Castrol EDGE 0W-20 Full Synthetic Motor Oil is engineered for drivers seeking peak engine performance and unmatched protection. This advanced oil is 3X stronger against viscosity breakdown and delivers 10X better performance under high-stress conditions, ensuring your engine stays resilient even in demanding environments. With a remarkable 20,000-mile interval between oil changes or one year, it offers exceptional value and convenience. Formulated to exceed API SQ/SP/SN PLUS/SN standards and meet stringent requirements like Chrysler MS 6395 and Ford WSS-M2C945-B1, this oil is compatible with a wide range of modern engines. Its full synthetic composition ensures superior wear protection, sludge control, and thermal stability, while its SAE 0W-20 weight optimizes fuel economy and high-temperature performance. Whether you’re tackling daily commutes or long road trips, this oil is designed to maximize engine efficiency and durability, making it a reliable choice for maintaining your vehicle’s health.

Product Features:


Product Features:
  • 3X Stronger than the leading full synthetic (1)
  • 10X Better high stress performance (2)
  • 20,000 miles between oil changes (3)
  • (1) Viscosity breakdown as measured in Kurt Orbahn test on 5W-30 grade
  • (2) As measured in Seq IX test under high load/torque conditions vs. API SQ test limits
  • (3) Or one year, whichever comes first
  • Approved and Licensed Specifications:
  • Exceeds API SQ/SP/SN PLUS/SN
  • ILSAC GF-7
  • Meets engine test requirements of Chrysler MS 6395
  • Meets Ford WSS-M2C945-B1
  • Meets Ford WSS-M2C960-A1
  • Meets Ford WSS-M2C962-A1
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Valvoline – Advanced Full Synthetic 0W-20 Motor Oil, Maximizes Engine Life, 5 Quart (Part No.881150)

Advanced Full Synthetic 0W-20 Motor Oil, Maximizes Engine Life, 5 Quart

from

$36.99
Today’s advanced engine technology requires advanced protection. Valvoline Advanced Full Synthetic, the motor oil designed to protect today’s sophisticated engines, contains premium anti-wear additives, superior antioxidants and extra detergents. It protects 40% better against wear, resists oil breakdown 10-times better, and defends 25% more against deposits than industry standards for maximum performance and engine longevity. And with an exceptional range of temperature protection your engine will ready for extreme weather. Valvoline invented motor oil 150 years ago, and we’ve been reinventing it ever since. Get Valvoline Advanced Full Synthetic and give your engine the advanced protection proven to maximize engine life.

Product Features:
  • ADVANCED PROTECTION AGAINST the four main causes of engine breakdown: wear friction heat and deposits
  • 40% BETTER WEAR PROTECTION vs. industry standard as tested in the Sequence IVB engine test
  • 25% BETTER DEPOSIT PROTECTION with superior engine cleaning detergents as tested in the GMOD engine test
  • EXCEPTIONAL HIGH/LOW TEMPERATURE PROTECTION defends your motor no matter the weather conditions
  • MEETS OR EXCEEDS ALL REQUIREMENTS of ILSAC GF-6A, API SP, API SN with SN PLUS, API SN, GM dexos 1 Gen 3
  • Enhanced Oil Stability: Resists oil breakdown 10 times better than industry standards, providing consistent performance and reliability.
  • Premium Additives: Contains premium anti-wear additives, superior antioxidants, and extra detergents for maximum performance and engine longevity.
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Valvoline – Full Synthetic High Mileage 0W-20 Motor Oil, Maximizes Engine Life, 5 Quart (Part No.881168)

Full Synthetic High Mileage 0W-20 Motor Oil, Maximizes Engine Life, 5 Quart

from

$36.99
Upgrading your motor oil to Valvoline Full Synthetic High Mileage with MaxLife Technology can help you increase the longevity of your car, truck or SUV with over 75,000 miles. It’s proven to protect your high-mileage motor against wear, friction, heat, and deposits – the leading causes of engine breakdown and expensive repairs. Our exclusive formulation goes beyond industry standards to protect your engine. It’s fortified with enhanced wear additives and friction-fighting agents to safeguard critical engine components, extra detergents to clean inside your engine, and premium seal conditioners to restore aging seals and prevent leaks. Superior viscosity modifiers and high-quality base oils help it perform exceptionally in both high and low temperatures. Engineered with ingenuity, tested with tenacity, and proven with purpose, our formula was innovated in America with a century and a half of hands-on experience from the original motor oil brand.

Product Features:
  • ENHANCED MAXLIFE TECHNOLOGY PREVENTS engine breakdown in extreme conditions with 50% better wear protection than the industry standard
  • TREAT AND PREVENT LEAKS with premium seal conditioners to keep oil out of places it shouldn’t be
  • 25% EXTRA DEFENSE AGAINST DEPOSITS, sludge, corrosion and rust via interior-cleansing detergents
  • EXTREME TEMPERATURE PROTECTION through our high-quality base oils and superior viscosity modifiers
  • MEETS OR EXCEEDS ALL REQUIREMENTS of ILSAC GF-6A, API SP, API SN with SN PLUS, API SN
  • Enhanced Wear Protection: Fortified with advanced wear additives to safeguard critical engine components, ensuring longevity for vehicles with over 75,000 miles.
  • Friction-Fighting Agents: Contains friction-fighting agents to reduce engine friction, enhancing overall engine efficiency and performance.
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Castrol – Edge 0W-20 Full Synthetic Motor Oil, Maximizes Engine Performance, 1 Quart (Part No.152C7A)

Edge 0W-20 Full Synthetic Motor Oil, Maximizes Engine Performance, 1 Quart

from

$11.99
Castrol EDGE 0W-20 is an advanced full synthetic motor oil and the optimal choice for drivers who want the best combination of wear protection, viscosity control and thermal stability to maximize engine performance. It is one of Castrol’s strongest engine oils with the strength to maintain this unsurpassed level of engine protection for up to 20,000 miles between oil changes or one year.

Product Features:


Product Features:
  • 3X Stronger against viscosity breakdown than leading full synthetic (1)
  • 10X Better High Temperature performance (2)
  • 20,000 miles between oil changes (3)
  • (1) Viscosity breakdown as measured in Kurt Orbahn test on 5W-30 grade
  • (2) As measured in Seq IX test under high load/torque conditions vs. API SP test limits
  • (3) Or one year, whichever comes first
  • Approved and Licensed Specifications:
  • Exceeds API SP/SN PLUS/SN/SM
  • ILSAC GF-6
  • GM dexos1 Gen 3
  • Meets engine test requirements of Chrysler MS 6395
  • Meets Ford WSS-M2C947-B1
  • Meets Ford WSS-M2C962-A1
See More

Valvoline – Advanced Full Synthetic 0W-20 Engine Oil, Maximizes Engine Life, 1 Quart (Part No.VV916)

Advanced Full Synthetic 0W-20 Engine Oil, Maximizes Engine Life, 1 Quart

from

$11.49
The Valvoline Advanced Full Synthetic 0W-20 Motor Oil is a high-quality engine oil that is designed to maximize the life of your engine. This product is available in a 1-quart size and is formulated with conventional oil composition. The oil class is standard and the SAE oil weight is 0W-20. This engine oil is perfect for those who want to keep their engine running smoothly and efficiently. It is designed to provide superior protection against wear and tear, as well as reduce engine deposits and sludge. With its advanced formula, this motor oil is sure to keep your engine running at its best for years to come. If you want to ensure the longevity of your engine, the Valvoline Advanced Full Synthetic 0W-20 Motor Oil is an excellent choice.

Product Features:
  • ADVANCED PROTECTION AGAINST the four main causes of engine breakdown: wear friction heat and deposits
  • 40% BETTER WEAR PROTECTION vs. industry standard as tested in the Sequence IVB engine test
  • 25% BETTER DEPOSIT PROTECTION with superior engine cleaning detergents as tested in the GMOD engine test
  • EXCEPTIONAL HIGH/LOW TEMPERATURE PROTECTION defends your motor no matter the weather conditions
  • MEETS OR EXCEEDS ALL REQUIREMENTS of ILSAC GF-6A, API SP, API SN with SN PLUS, API SN, GM dexos 1 Gen 3
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Royal Purple – SAE 0W-20 Synthetic Motor Oil, Superior Protection & Performance, 5 Quart (Part No.51020)

SAE 0W-20 Synthetic Motor Oil, Superior Protection & Performance, 5 Quart

from

$41.99
Royal Purple Motor Oil is a specially formulated multi viscocity oil for use in gasoline and diesel engines of all types from cars and trucks to SUVs, motorcycles and boats. Royal Purple(R) Motor Oil with Synerlec(R) additive technology reduces friction, which results in a 1-3 percent increase in horsepower, lowers operating temperatures, provides superior corrosion protection, improves fuel economy, reduces emissions and extends oil life. A.P.I. Certified.

Product Features:
  • Better wear protection
  • Increased fuel efficiency
  • Better protection of the expensive catalytic emission system
  • Improved compatibility with fuels containing ethanol
  • Superior corrosion protection
  • High Performance: SAE 0W-20 Synthetic Engine Oil is specially formulated to provide high performance for gasoline and diesel engines of all types, including cars, trucks, SUVs, motorcycles, and boats.
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FRAM – 0W-20 Full Synthetic Motor Oil, Helps Extend Engine Life, 5 Quart (Part No.F900-5QT)

0W-20 Full Synthetic Motor Oil, Helps Extend Engine Life, 5 Quart

from

$27.99
FRAM Engine Oil Full Synthetic SAE 0W-20 is a full synthetic motor oil blended with high quality synthetic base stocks and the latest additive technology to meet the stringent API: SP, SN, SM, SL, SJ, GM dexos1 Gen 2 and ILSAC GF-6A specifications to provide the ultimate protection for your engine. Specifically formulated for the rigorous environment of gas-direct engine (GDI) and turbo gas-direct engine (TGDI) designs as well as providing increased protection for carbureted or normally fuel injected engines. FRAM Engine Oil Full Synthetic SAE 0W-20 contains additive technology designed to prevent low-speed pre-ignition (LSPI). LSPI can lead to pre-mature engine failure and is a major concern of the automotive industry for vehicles employing GDI or TGDI technology. This oil also provides increased wear protection, oxidation and shear stability over previous oil categories. FRAM Engine Oil Full Synthetic SAE 0W-20 and is a fully licensed GM dexos1 Gen 2 motor oil.

Product Features:
  • Faster oil flow at start-up
  • Fuel efficiency gains over heavier grade oils
  • Excellent sludge and varnish protection
  • Outstanding thermal and oxidation stability, lowers oil vaporization and consumption at extreme conditions
  • Always refer to your vehicles operating manual to select the correct grade oil for your engine.
  • Ultimate engine protection: FRAM Full Synthetic 0W20 5 QT is specifically formulated to meet the stringent API: SP, SN, SM, SL, SJ, GM dexos1 Gen 2 and ILSAC GF-6A specifications to provide the ultimate protection for your engine.
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Castrol – Edge 0W-20 Full Synthetic Motor Oil, Reduces Leaks & Burnoff, 5 Quart (Part No.15B0D2)

Edge 0W-20 Full Synthetic Motor Oil, Reduces Leaks & Burnoff, 5 Quart

from

$37.99
Castrol EDGE High Mileage 0W-20 is an advanced full synthetic motor oil that is specifically designed for vehicles with over 75,000 miles. It’s been engineered to reduce leaks, burnoff and power robbing deposits, but also contains a proprietary additive to protect the emission system. Our Phosphorus Replacement Technology reduces harmful phosphorus to protect the catalytic converter and extend maximum performance. It is the natural choice for drivers who demand maximum performance from their high mileage car.

Product Features:


Product Features:
  • Phosphorus Replacement Technology to help extend the life of the emission system
  • Reduces leaks, oil burnoff and power robbing deposits
  • 15,000 miles between oil changes (1)
  • (1) Or one year, whichever comes first
  • Meets or exceeds the following specifications:
  • API SP/SN PLUS/SN/SM
  • ILSAC GF-6
  • Meets Ford WSS-M2C947-B1
  • Meets engine test requirements of Chrysler MS 6395
  • Meets Ford WSS-M2C962-A1
See More

FRAM – High Mileage 0W-20 Full Synthetic Motor Oil, Reduces Oil Consumption, 5 Quart (Part No.F913-5QT)

High Mileage 0W-20 Full Synthetic Motor Oil, Reduces Oil Consumption, 5 Quart

from

$27.99
FRAM Full Synthetic High Mileage SAE 0W-20 is a full synthetic motor oil blended with high quality synthetic base stocks and and enhanced additives that meet the stringent API: SP, SN, SM, SL, SJ, and ILSAC GF-6A specifications while reducing leaks and oil consumption in worn or higher mileage engines. Formulated with synthetic base stocks, this oil offers increased oxidation inhibition performance as well as increased high and low temperature performance when compared against conventional oils. The FRAM Full Synthetic High Mileage SAE 0W-20 is formulated to help clean out sludge buildup and keep engines running clean and with increased efficiency and power. Specially designed for engines with over 75,000 miles, the FRAM Full Synthetic High Mileage SAE 0W-20 provides the ultimate protection for your higher mileage engine. Specifically formulated for the rigorous environment of gas-direct engine (GDI) and turbo gas-direct engine (TGDI) designs as well as providing increased protection for carbureted or normally fuel injected engines. FRAM Full Synthetic High Mileage SAE 0W-20 contains additive technology designed to prevent low-speed pre-ignition (LSPI). LSPI can lead to pre-mature engine failure and is a major concern of the automotive industry for vehicles employing GDI or TGDI technology. This oil also provides increased wear protection, oxidation and shear stability for higher mileage vehicles over previous oil categories.

Product Features:
  • Faster oil flow at start-up
  • Fuel efficiency gains over heavier grade oils
  • Reduces oil cumsumption
  • Excellent sludge and varnish protection
  • Slows engine leaks
  • Outstanding thermal and oxidation stability
  • Lowers oil vaporization and consumption at extreme conditions
  • Always refer to your vehicles operating manual to select the correct grade oil for your engine.
See More

FRAM – 0W-20 Full Synthetic Motor Oil, Faster Oil Flow, 1 Quart (Part No.F900)

0W-20 Full Synthetic Motor Oil, Faster Oil Flow, 1 Quart

from

$7.49
FRAM Engine Oil Full Synthetic SAE 0W-20 is a full synthetic motor oil blended with high quality synthetic base stocks and the latest additive technology to meet the stringent API: SP, SN, SM, SL, SJ, GM dexos1 Gen 2 and ILSAC GF-6A specifications to provide the ultimate protection for your engine. Specifically formulated for the rigorous environment of gas-direct engine (GDI) and turbo gas-direct engine (TGDI) designs as well as providing increased protection for carbureted or normally fuel injected engines. FRAM Engine Oil Full Synthetic SAE 0W-20 contains additive technology designed to prevent low-speed pre-ignition (LSPI). LSPI can lead to pre-mature engine failure and is a major concern of the automotive industry for vehicles employing GDI or TGDI technology. This oil also provides increased wear protection, oxidation and shear stability over previous oil categories. FRAM Engine Oil Full Synthetic SAE 0W-20 and is a fully licensed GM dexos1 Gen 2 motor oil.

Product Features:
  • Faster oil flow at start-up
  • Fuel efficiency gains over heavier grade oils
  • Excellent sludge and varnish protection
  • Outstanding thermal and oxidation stability, Lowers oil vaporization and consumption at extreme conditions
  • ALWAYS REFER TO YOUR VEHICLES OPERATING MANUAL TO SELECT THE CORRECT GRADE OIL FOR YOUR ENGINE.
  • Ultimate Engine Protection: FRAM Engine Oil Full Synthetic SAE 0W-20 is formulated with high-quality synthetic base stocks and the latest additive technology to meet stringent API and ILSAC specifications, ensuring top-tier protection for your engine.
  • Advanced LSPI Prevention: Specifically designed to prevent low-speed pre-ignition (LSPI), a major concern for GDI and TGDI engines, reducing the risk of premature engine failure.
  • Versatile Compatibility: Suitable for gas-direct engine (GDI), turbo gas-direct engine (TGDI), carbureted, and normally fuel-injected engines, offering broad application across various engine types.
  • GM dexos1 Gen 2 Licensed: Fully licensed as GM dexos1 Gen 2 motor oil, ensuring it meets the high standards required for modern engines, including those from General Motors.
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Castrol – Edge 0W-20 Full Synthetic Motor Oil, Reduces Leaks & Burnoff, 1 Quart (Part No.15B0D3)

Edge 0W-20 Full Synthetic Motor Oil, Reduces Leaks & Burnoff, 1 Quart

from

$11.99
Castrol EDGE High Mileage 0W-20 is an advanced full synthetic motor oil that is specifically designed for vehicles with over 75,000 miles. It’s been engineered to reduce leaks, burnoff and power robbing deposits, but also contains a proprietary additive to protect the emission system. Our Phosphorus Replacement Technology reduces harmful phosphorus to protect the catalytic converter and extend maximum performance. It is the natural choice for drivers who demand maximum performance from their high mileage car.

Product Features:


Product Features:
  • Phosphorus Replacement Technology to help extend the life of the emission system
  • Reduces leaks, oil burnoff and power robbing deposits
  • 15,000 miles between oil changes (1)
  • (1) Or one year, whichever comes first
  • Meets or exceeds the following specifications:
  • API SP/SN PLUS/SN/SM
  • ILSAC GF-6
  • Meets Ford WSS-M2C947-B1
  • Meets engine test requirements of Chrysler MS 6395
  • Meets Ford WSS-M2C962-A1
See More

FRAM – High Mileage 0W-20 Full Synthetic Motor Oil, Reduces Oil Consumption, 1 Quart (Part No.F913)

High Mileage 0W-20 Full Synthetic Motor Oil, Reduces Oil Consumption, 1 Quart

from

$7.49
FRAM Full Synthetic High Mileage SAE 0W-20 is a full synthetic motor oil blended with high quality synthetic base stocks and and enhanced additives that meet the stringent API: SP, SN, SM, SL, SJ, and ILSAC GF-6A specifications while reducing leaks and oil consumption in worn or higher mileage engines. Formulated with synthetic base stocks, this oil offers increased oxidation inhibition performance as well as increased high and low temperature performance when compared against conventional oils. The FRAM Full Synthetic High Mileage SAE 0W-20 is formulated to help clean out sludge buildup and keep engines running clean and with increased efficiency and power. Specially designed for engines with over 75,000 miles, the FRAM Full Synthetic High Mileage SAE 0W-20 provides the ultimate protection for your higher mileage engine. Specifically formulated for the rigorous environment of gas-direct engine (GDI) and turbo gas-direct engine (TGDI) designs as well as providing increased protection for carbureted or normally fuel injected engines. FRAM Full Synthetic High Mileage SAE 0W-20 contains additive technology designed to prevent low-speed pre-ignition (LSPI). LSPI can lead to pre-mature engine failure and is a major concern of the automotive industry for vehicles employing GDI or TGDI technology. This oil also provides increased wear protection, oxidation and shear stability for higher mileage vehicles over previous oil categories.

Product Features:
  • Faster oil flow at start-up
  • Fuel efficiency gains over heavier grade oils
  • Reduces oil cumsumption
  • Excellent sludge and varnish protection
  • Slows engine leaks
  • Outstanding thermal and oxidation stability
  • Lowers oil vaporization and consumption at extreme conditions
  • Always refer to your vehicles operating manual to select the correct grade oil for your engine.
See More

Valvoline – 0W-20 Full Synthetic Motor Oil, Superior Performance in Extremes, 5 Gallon (Part No.881663)

0W-20 Full Synthetic Motor Oil, Superior Performance in Extremes, 5 Gallon

from

$134.99
Valvoline Full Synthetic Motor Oil delivers superior engine protection by fighting the three major causes of engine stress: heat, deposits and wear. When you want to keep your engine running its best, choose the ultimate protection found in Valvoline Full Synthetic Motor Oil. Valvoline Full Synthetic Motor Oil meets the GM(1) dexos1 Gen2 and API SN PLUS specifications, helping protect gasoline direct injected engines from low-speed pre-ignition.

Product Features:


Product Features:
  • Excellent engine cleanliness through superior sludge and varnish protection
  • Outstanding high-temperature protection under severe driving conditions
  • Superior cold-temperature protection through faster oil flow at start-up
  • Is fully compatible with all conventional and leading synthetic motor oils
  • Provides advanced protection against low-speed pre-ignition (LSPI) in gasoline direct-injected engines, meeting GM dexos1 Gen2 and API SN PLUS standards.
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LIQUI MOLY – Top Tec 6600 0W-20 Full Synthetic Motor Oil, Improves Engine Efficiency, 5 Liter (Part No.22046)

Top Tec 6600 0W-20 Full Synthetic Motor Oil, Improves Engine Efficiency, 5 Liter

from

$68.99
Top Tec 6600 0W-20 Full Synthetic Motor Oil is engineered for superior performance and efficiency. Its low-friction, fully synthetic formula ensures smooth engine operation, outstanding cleanliness, and excellent wear protection. The 0W-20 viscosity grade delivers exceptional cold start performance, enhancing engine efficiency while reducing fuel consumption. Designed with innovative additive technology, this oil provides high lubrication reliability, greater oxidation stability, and extended engine life. Ideal for use with extended oil change intervals as recommended by the manufacturer, it offers unmatched value for modern engines. Perfectly suited for drivers seeking top-tier protection and performance in a 5-liter package.

Product Features:


Product Features:
  • Smooth engine running
  • Outstanding engine cleanliness
  • Excellent wear protection
  • High lubrication reliability
  • Enhanced cold start performance for improved engine efficiency and reduced fuel consumption.
See More

LIQUI MOLY – Molygen 0W-20 Full Synthetic Engine Oil, Reduces Friction & Deposits (Part No.20438)

Molygen 0W-20 Full Synthetic Engine Oil, Reduces Friction & Deposits

from

$56.99
Fully synthetic LIQUI MOLY specialty with a unique additive technology. The powerful MFC (Molecular Friction Control) technology prevents formation of deposits while simultaneously reducing frictional losses. The synergetic effect provides optimum wear protection even under tough operating conditions. Improved fuel consumption and increased engine life are some of the end results. The oils fluorescent green color is typical for the MFC formulation.

Product Features:


Product Features:
  • smooth engine running
  • optimum oil pressure under all operating conditions
  • long engine service life
  • reduces pollutant emissions
  • Enhanced fuel efficiency through advanced Molecular Friction Control technology.
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Valvoline – Hybrid Full Synthetic 0W-20 Motor Oil, Maximizes Engine Life, 5 Quart (Part No.898664)

Hybrid Full Synthetic 0W-20 Motor Oil, Maximizes Engine Life, 5 Quart

from

$39.99
Unlike conventional cars, a hybrid has different demands placed on its engine and motor oil. The frequent stop-and-start cycle and longer periods of inactivity don’t allow the engine and oil to reach optimal operating temperature for proper protection. That can lead to increased condensation and fuel dilution, causing corrosion, engine wear, and sludge. It can also hurt a hybrid vehicle’s fuel efficiency. That’s why Valvoline formulated a Hybrid Vehicle Full Synthetic Motor Oil. Engineered for the specific needs of hybrids, our exclusive Trap and Lock Technology suspends water molecules in the oil to prevent damage from fuel and water, while ensuring proper lubrication of all metal surfaces. Valvoline Hybrid Vehicle Full Synthetic features an anti-corrosion shield for enhanced protection against rust. Whether your hybrid uses 0W-20 full synthetic or another grade, Valvoline has a full synthetic motor oil to protect your hardworking hybrid. Keep your engine running efficiently mile after mile with Valvoline Full Synthetic Motor Oil. Look for Valvoline’s complete line of Hybrid Performance Fluids – from the original motor oil brand trusted for more than 150 years.

Product Features:
  • Engineered specifically for hybrid vehicles
  • Because a hybrid vehicle engine starts and stops frequently, the engine oil doesn’t reach optimal operating temperature, leading to condensation and fuel dilution
  • Valvoline’s innovative trap and lock technology suspends water molecules in the oil to prevent damage from fuel and water
  • Anti-corrosion shield provides enhanced protection against rust
  • Formulated for Hybrid Vehicles: Valvoline Hybrid Full Synthetic Engine Oil is specifically designed to meet the unique demands of hybrid engines, providing optimal protection and performance.
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LIQUI MOLY – Top Tec 6600 0W-20 Full Synthetic Motor Oil, Improves Engine Efficiency, 1 Liter (Part No.22044)

Top Tec 6600 0W-20 Full Synthetic Motor Oil, Improves Engine Efficiency, 1 Liter

from

$20.49
Top Tec 6600 0W-20 Full Synthetic Motor Oil is engineered for superior performance, offering low friction and exceptional cold start behavior to enhance engine efficiency and reduce fuel consumption. Its advanced additive technology ensures outstanding wear protection, superb engine cleanliness, and greater oxidation stability, making it ideal for modern engines. With a low viscosity formula, this motor oil promotes smooth engine running and high lubrication reliability, even under demanding conditions. Designed for use with extended oil change intervals as specified by the manufacturer, it delivers long-lasting value and optimal engine care. Perfect for drivers seeking reliability and efficiency, this 1-liter solution is a smart choice for maintaining peak engine performance.

Product Features:


Product Features:
  • Smooth engine running
  • Outstanding engine cleanliness
  • Excellent wear protection
  • High lubrication reliability
  • Enhanced cold start performance for improved engine efficiency and reduced fuel consumption.
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LIQUI MOLY – Molygen New Generation 0W-20 Full Synthetic Engine Oil, Reduces Friction & Deposits (Part No.20436)

Molygen New Generation 0W-20 Full Synthetic Engine Oil, Reduces Friction & Deposits

from

$18.99
Fully synthetic LIQUI MOLY specialty with a unique additive technology. The powerful MFC (Molecular Friction Control) technology prevents formation of deposits while simultaneously reducing frictional losses. The synergetic effect provides optimum wear protection even under tough operating conditions. Improved fuel consumption and increased engine life are some of the end results. The oils fluorescent green color is typical for the MFC formulation.

Product Features:


Product Features:
  • smooth engine running
  • optimum oil pressure under all operating conditions
  • long engine service life
  • reduces pollutant emissions
  • Improved fuel efficiency through reduced frictional losses.
See More

Valvoline – Hybrid 0W-20 Full Synthetic Motor Oil, Maximizes Engine Life, 1 Quart (Part No.888414)

Hybrid 0W-20 Full Synthetic Motor Oil, Maximizes Engine Life, 1 Quart

from

$12.79
To get the most out of the unique demands of your hybrid vehicle, you need Valvoline Hybrid Vehicle Full Synthetic. Our formulation is specially designed to shield your hybrid motor against wear, friction, heat, and deposits – the leading causes of engine breakdown and expensive repairs. It goes above and beyond to protect your hybrid motor with high-quality additives that defend against sludge and deposits, and extend the peak performance of your engine. While extra detergents and dispersants help resist oil breakdown and reduce exhaust system damage to critical engine parts. And because it performs its best in even the most difficult climate and driving conditions, you can rest assured your hybrid engine will be prepared for anything the road brings, both today and tomorrow. It’s simply the ultimate protection for your hybrid vehicle. Engineered with ingenuity, tested with tenacity, and proven with purpose, our formula was innovated in America with a century and a half of hands-on experience from the original motor oil brand.

Product Features:
  • Ultimate protection against sludge & deposits to keep your hybrid engine performing at its best
  • Cut down on costly repairs by minimizing exhaust system damage to your engine’s vital components
  • Resist oil breakdown with extra detergents allowing our oil to remain effective longer
  • Exceptional temperature protection defends your engine in even the most intense weather conditions
  • Specially designed for hybrid vehicles: Valvoline Hybrid Vehicle Full Synthetic 0W-20 Engine Oil is formulated to meet the unique demands of hybrid engines, providing ultimate protection against wear, friction, heat, and deposits.
  • High-quality additives: This engine oil is fortified with high-quality additives that defend against sludge and deposits, extending the peak performance of your engine.
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FAQs for 2022 Lexus RX350 Engine Oils

Which Engine Oils are the top sellers for the 2022 Lexus RX350?

Out of 19 Engine Oils that fit 2022 Lexus RX350s, the following parts are the top sellers:
0W-20 Full Synthetic Motor Oil, Helps Extend Engine Life, 5 Quart
from $27.99
This product is not rated
0W-20 Full Synthetic Motor Oil, Helps Extend Engine Life, 5 Quart
Engine Oil

How can I make sure that a part will be compatible with my 2022 Lexus RX350?

Our Lexus RX350 aftermarket and OEM parts are designed specifically for the 2022 model. You can always find your specific fitment and compatibility for your 2022 Lexus on an individual product page.

What is the price range for 2022 Lexus RX350 Engine Oils?

The range of prices of Engine Oils for the 2022 Lexus RX350 goes from $7.49 up to $134.99 for the most premium parts.

What is the average price of 2022 Lexus RX350 Engine Oils?

2022 Lexus RX350 Engine Oils average $34.30 for our selection of OEM and aftermarket parts.

Does Advance Auto Parts sell Engine Oils for other Lexus RX350 model years?

Yes, we currently stock Engine Oils for 17 model years of Lexus RX350s, from 2007 to 2025. Model years 2021, 2020, 2019, 2018, 2017, 2016, 2015, 2014, and 2013 are the most popular for Engine Oils purchases.

Which Engine Oils are highest rated for the 2022 Lexus RX350?

Based on 4,658 customer reviews, our 2022 Lexus RX350 Engine Oils have an average rating of 5. Explore our top-rated Engine Oils here:
SAE 0W-20 Synthetic Motor Oil, Superior Protection & Performance, 5 Quart
from $41.99
(8)
SAE 0W-20 Synthetic Motor Oil, Superior Protection & Performance, 5 Quart
“I use at every oil change”

Can I get help with 2022 Lexus RX350 Engine Oils orders?

Contact our customer support team, by chat or phone, through the help desk page, where you can find instant answers about Lexus Engine Oils and more.

What is your return policy for Lexus RX350 Engine Oils?

Advance Auto Parts keeps returns simple. For new Lexus RX350 Engine Oils and accessories, your online orders can be returned, in their original condition, within 45 days. For requirements, see the returns page.