2022 Ford E-350 Super Duty Spark Plugs

Keep Your 2022 Ford E-350 Super Duty in Top Shape with Quality Spark Plugs

Whether you’re repairing or upgrading your Spark Plug, using high-quality parts is key to keeping your 2022 Ford E-350 Super Duty looking sharp and performing at its best. At Advance Auto Parts we carry a wide selection of dependable options, including Single Spark Plug Wires and Spark Plugs. Whether you’re replacing a damaged part or enhancing your truck’s style and protection, you’ll find exactly what you need to get the job done right.

Top-Rated Spark Plugs from Trusted Brands

Looking for a reliable Spark Plug? We’ve got you covered with options from brands you know and trust like Autolite, NGK, and E3. For example, Autolite Spark Plugs start at just $10.99 with an average 4.6 star rating. NGK and E3 offer similar pricing and quality, backed by strong customer feedback. With over 218 reviews and a solid 5 star average, you can shop with confidence knowing other Ford E-350 Super Duty owners approve.

Competitive Prices and Extensive Inventory

The average price for a 2022 Ford E-350 Super Duty Spark Plug at Advance Auto Parts is around $16.06, with a range that starts at $7.99 and goes up to $39.99. With 7 options in stock from 4 trusted brands, finding the right fit is easy. Popular picks like Iridium Ultra Fine Wire Spark Plug: Laser Welded for Optimum Performance, Ruthenium HX Spark Plug (LTR7BHX): High Ignitability & Durability, and Laser Platinum Spark Plug (LTR7CP13): Fine Wire Tip for High Ignitability start at just $10.99 and offer a great balance of form and function.

Explore Related Parts

While you’re upgrading or replacing your Spark Plug, don’t forget to check out other key components like Ignition Sensors and Ignition Switches. At Advance Auto Parts, we’re here to help you keep your 2022 Ford E-350 Super Duty in peak condition, inside and out.

Essential 2022 Ford E-350 Super Duty Spark Plugs

Autolite Iridium – Iridium Ultra Fine wire Spark Plug: Optimal Fuel Efficiency & Ignitability (Part No.AI5862)

Iridium Ultra Fine wire Spark Plug: Optimal Fuel Efficiency & Ignitability

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$10.99
The Autolite Iridium Ultra Fine wire Spark Plug is a premium OE replacement designed to deliver exceptional performance and reliability. Featuring a laser-welded proprietary iridium alloy finewire center electrode, it ensures optimal fuel efficiency, improved acceleration, and precise ignitability. The nickel-plated shell offers superior corrosion resistance, while the high-alumina ceramic insulator enhances strength and durability under extreme conditions. With advanced platinum sidewire technology, this spark plug provides long-lasting performance and consistent ignition. Engineered for excellence, its the perfect choice for drivers seeking enhanced engine efficiency and dependable operation.

Product Features:
  • Autolite Iridium Ultra is an engineered OE replacement iridium spark plug.
  • A laser-welded proprietary iridium alloy finewire center electrode provides optimal fuel efficiency, acceleration and focused ignitability.
  • Nickel-plated shell to resist corrosion.
  • High-alumina ceramic insulator for increased strength.
  • Laser welded Iridium finewire center electrode.
  • Proprietary platinum sidewire technology.
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E3 – DiamondFIRE Automotive Spark Plug: More Power & Fuel Efficiency (Part No.E3.53)

DiamondFIRE Automotive Spark Plug: More Power & Fuel Efficiency

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$8.49
The Premium DiamondFire Automotive Spark Plug is engineered to deliver peak performance and efficiency for your vehicle. Featuring E3’s patented Diamond Fire edge-to-edge ground electrode, it ensures a faster, more complete burn for smoother acceleration and idle. The innovative “diamond-shaped” side wire electrode enhances combustion by quickly igniting the air/fuel mixture, resulting in a larger and faster flame kernel. This translates to improved power output – up to 6% on average – and better fuel efficiency, saving you money while reducing engine carbon deposits. Constructed with durable nickel for both the center and ground electrode tips, this spark plug is built to last. Its tapered seat design ensures a secure fit, and the pre-gapped configuration eliminates the need for adjustments, making installation hassle-free. With its advanced technology, this spark plug not only boosts performance but also promotes cleaner combustion, making it a smart upgrade for any vehicle.

Product Features:
  • E3’s Diamond Fire edge to edge ground electrode provides maximum performance with increased efficiency and a faster more complete burn
  • Smoother Acceleration & Idle – The faster flame initiated by the spark plug results in a more complete burn of the ingested fuel charge. More pressure is created against the piston more fuel is put to work
  • Energy – Power output improved up to 6% on average in the typical operating ranges. Results will vary.
  • Efficiency – The “diamond shaped” side wire electrode projects the combustion spark in a way that more quickly ignites the air/fuel mixture, thereby creating a significantly faster and larger flame kernel. The result is that more fuel is put to work durin
  • E3’s patented Diamond Fire Technology provides a cleaner burning combustion, which translates into fuel savings and reduced engine carbon deposits
  • The Spark Plugs are pre-gapped at the factory and cannot be adjusted.
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Champion – Platinum Power Spark Plug (RES8PYB5): Powerful Performance & Durability (Part No.3017)

Platinum Power Spark Plug (RES8PYB5): Powerful Performance & Durability

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$4.99
Champion Platinum Power spark plugs are engineered to deliver exceptional performance and durability, making them an ideal choice for maintaining peak engine efficiency. Featuring a platinum center electrode, these spark plugs ensure long-lasting reliability and consistent performance. The fine-wire center electrode enhances ignitability, while the V-trimmed ground electrode sharpens spark focus for optimal combustion. Constructed with the exclusive Heat-Active alloy, the electrodes quickly reach and maintain the ideal operating temperature, ensuring smooth engine operation under various conditions. The platinum-tipped center wire resists wear and helps preserve the proper gap specification throughout the plug’s lifespan, reducing the need for frequent replacements. Designed as a standard replacement with a tapered seat type, these spark plugs are built to meet or exceed OEM Standards. With a nickel ground electrode tip and integrated resistor, they provide dependable performance and value for a wide range of vehicles.

Product Features:
  • Platinum Power- Premium Spark Plug. Powerful Performance.
  • Platinum center electrode for long life
  • Fine-wire center electrode for greater ignitability
  • V-trimmed ground electrode promotes sharper spark focus
  • Heat-Active alloy allows electrodes to reach optimal temperature
  • Platinum tipped center wire resists wear and helps to maintain proper gap spec over life of the plug
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DENSO – Iridium Power Spark Plug: Maximum Spark Energy, 0.4mm Iridium Tip, IT16 (Part No.5325)

Iridium Power Spark Plug: Maximum Spark Energy, 0.4mm Iridium Tip, IT16

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$9.99
The Iridium Power Spark Plug features the world’s smallest Iridium Center Electrode at just 0.4mm, delivering unmatched spark precision for maximum combustion efficiency. Engineered with a patented 360-degree laser welding assembly process, this spark plug ensures exceptional durability and reliability under extreme conditions. Its U-groove and taper-cut ground electrode design optimizes flame propagation, enhancing engine performance and fuel efficiency. Built to withstand temperatures exceeding 4000 Deg F, it is burnished with nickel plating for superior high-temperature endurance and corrosion resistance. Designed for versatility, it offers a wide range of part numbers to fit thousands of applications, including classic and collector cars. With its Iridium tip and tapered seat type, this spark plug is the ultimate choice for drivers seeking maximum spark energy, durability, and long-lasting performance.

Product Features:
  • World’s smallest Iridium Center Electrode (0.4mm) for improved spark for maximum combustion
  • Patented 360-degree laser welding assembly process
  • U-groove and taper cut ground electrode to maximize flame propagation.
  • Withstands temperatures greater than 4000 degree Fahrenheit
  • Burnished nickel plating for high temperature endurance and superior corrosion resistance
  • Wide range of part numbers for thousands of applications, including classic and collector cars
  • Iridium Power
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NGK – G-Power Spark Plug (LTR6GP): Enhanced Durability & Fuel Efficiency (Part No.90198)

G-Power Spark Plug (LTR6GP): Enhanced Durability & Fuel Efficiency

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$8.99
NGK G-Power Platinum spark plugs are the best single platinum spark plugs at an economical price. G-Power plugs feature a fine wire platinum center electrode and a trapezoidal cut ground electrode that offers increased durability, improved fuel efficiency, lower emissions, faster starts and quicker acceleration over conventional nickel spark plugs. An excellent upgrade for vehicles which used nickel alloy spark plugs originally. For better performance consider upgrading to a NGK Iridium IX plug. For even greater performance consider upgrading to a NGK RUTHENIUM HX plug.

Product Features:
  • SINGLE PLATINUM TIP: Fine wire 0.6 millimeter platinum tip center electrode ensures improved durability and a consistently stable spark
  • PLATINUM ALLOY: G-Power platinum provides exceptional value with increased performance and longer service intervals than factory nickel plugs
  • TRAPEZOIDAL CUT GROUND ELECTRODE: Reduces quenching design produces improved ignitability and performance
  • SOLID COPPER CORE: 98% pure copper core offers superior heat dissipation, conductivity and ultra wide heat ranges
  • COLD-ROLLED THREADS: Prevents cross-threading and damage to cylinder heads
  • RECOMMENDED USAGE: Lower cost alternative to double precious metal spark plugs or as an upgrade to OE nickel alloy spark plugs
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Motorcraft – Double Platinum Spark Plug (CYFS12FP): Enhanced Durability & Reliability (Part No.SP-526)

Double Platinum Spark Plug (CYFS12FP): Enhanced Durability & Reliability

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$9.99
Double Platinum Spark Plug (CYFS12FP) offers exceptional durability and reliability, making it the ideal choice for maintaining peak engine performance. Engineered to meet strict Ford standards, these spark plugs are an exact fit for Ford, Lincoln, and Mercury vehicles, ensuring seamless compatibility. Featuring platinum center and ground electrode tips, they resist oxidation and arc erosion, delivering long-lasting performance with service intervals of up to 100,000 miles. The multi-rib insulator design protects against misfires, while the advanced engineering helps reduce fuel consumption, optimize emissions, and prevent false check engine lights. Backed by Motorcraft’s Service Parts Warranty, these spark plugs are crafted with high-quality materials to provide reliable performance across a wide range of domestic and import cars and trucks. Whether you’re replacing original equipment or upgrading, Motorcraft spark plugs deliver the confidence and reliability you need for smooth, efficient operation.

Product Features:
  • Motorcraft spark plugs are matched to specific engines to provide enhanced durability, eliminate misfires, reduce fuel consumption and optimize emissions.
  • Backed by Motorcraft’s Service Parts Warranty
  • Exact fit for Ford, Lincoln and Mercury vehicles
  • Resistant to oxidation and arc erosion.
  • Multi-rib insulator protects against misfire.
  • Service intervals of up to 100,000 miles.
  • Motorcraft Spark Plugs are designed with high quality materials to provide reliable performance for almost any application.
  • Motorcraft Spark Plugs are what was in the vehicle when it was manufactured
  • Motorcraft ignition components help prevent false check engine lights.
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Champion – Platinum Power Spark Plug (RS10PYC): Powerful Performance & Durability (Part No.3408)

Platinum Power Spark Plug (RS10PYC): Powerful Performance & Durability

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$4.49
Champion Platinum Power spark plugs are engineered to deliver exceptional performance and durability, making them an ideal choice for maintaining peak engine efficiency. Featuring a platinum center electrode, these spark plugs ensure long-lasting reliability and consistent performance. The fine-wire center electrode enhances ignitability, while the V-trimmed ground electrode sharpens spark focus for optimal combustion. Constructed with the exclusive Heat-Active alloy, these plugs quickly reach and maintain the ideal operating temperature, ensuring smooth engine operation under various conditions. The platinum-tipped center wire resists wear and helps maintain the proper gap specification throughout the plug’s lifespan, reducing the need for frequent replacements. Designed as a standard replacement with a tapered seat type, these spark plugs are compatible with a wide range of vehicles. With a nickel ground electrode tip and integrated resistor, they provide dependable performance and value, making them a smart investment for any vehicle owner seeking reliable ignition components.

Product Features:
  • Platinum Power- Premium Spark Plug. Powerful Performance.
  • Platinum center electrode for long life
  • Fine-wire center electrode for greater ignitability
  • V-trimmed ground electrode promotes sharper spark focus
  • Heat-Active alloy allows electrodes to reach optimal temperature
  • Platinum tipped center wire resists wear and helps to maintain proper gap spec over life of the plug
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DENSO – Iridium TT Spark Plug: Ultimate Endurance and Power, 0.4mm Iridium Tip, IT16TT (Part No.4713)

Iridium TT Spark Plug: Ultimate Endurance and Power, 0.4mm Iridium Tip, IT16TT

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$13.99
The Iridium TT Spark Plug combines the durability of an OE-style plug with the power and torque of high-performance engineering, making it a standout choice for drivers seeking reliability and efficiency. Featuring a 0.4mm Iridium center electrode – the world’s smallest diameter – it maximizes firing potential, while the 0.7mm needle tip ground electrode promotes higher spark energy and minimizes heat quenching. Built with DENSO’s patented Iridium-Rhodium alloy formula, it boasts the highest concentration of Iridium for unmatched durability, withstanding temperatures over 4000 Deg F. The advanced Twin-Tip Technology pairs a fine wire Iridium center electrode with a needle tip Platinum ground electrode, ensuring superior ignition and fuel efficiency. Designed to enhance fuel economy and reduce emissions, this spark plug allows you to drive farther with fewer stops. Developed to original equipment specifications and utilizing a 360-degree laser welding process, it guarantees exceptional structural strength and consistent performance. Perfect for those who demand endurance and power in every drive.

Product Features:
  • 0.4mm Iridium Center Electrode: World’s Smallest Diameter that maximizes firing potential
  • 0.7mm Needle Tip Ground Electrode: Promotes higher spark energy and less heat quenching
  • DENSO Patented Optimized Iridium-Rhodium Alloy Formula: Highest concentration of Iridium vs. competitors for greater durability
  • DENSO Patented 360 degree laser welding process: Ensuring exceptional quality bond and structural strength with the Iridium Center Electrode
  • Durability of an OE style plug combined with Power and Torque of high performance.
  • Withstands temperatures greater than 4000 degree Fahrenheit
  • Iridium TT
  • Advanced Twin-Tip Technology: Combines a Fine Wire Iridium Center Electrode with a Needle Tip Platinum Ground Electrode for superior ignition and efficiency.
  • Enhanced Fuel Economy and Lower Emissions: Designed to provide better fuel economy and reduced emissions, allowing you to drive around the Earth over 4 times.
  • Original Equipment Specification: Developed from the Super Ignition Plug (SIP) design, ensuring reliable and consistent performance.
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Accel – HP Copper Spark Plug: Superior Heat Dissipation & Stronger Spark (Part No.8160C1)

HP Copper Spark Plug: Superior Heat Dissipation & Stronger Spark

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$184.99
ACCEL HP Spark Plugs are made with a Copper core which is a better conductor than Platinum and Iridium. They deliver a stronger spark especially in high performance applications where high combustion pressures are present. Copper is much better at dissipating heat than other materials which lessens the chance of a misfire. ACCEL HP Spark Plugs are capable allowing you to open the gap exposing a larger flame kernel or close it if needed for high boost applications. All ACCEL HP Spark Plugs have machine rolled threads allowing for a more precise thread engagement and torque retention.

Product Features:
  • One Piece Design – Won’t break off in head during removal like two piece designs
  • The Copper core is a better conductor than Iridium or Platinum plugs
  • Copper dissipates heat much better than other materials
  • C – Cut Design un-shrouds the spark kernel for a better burn
  • Unlike Iridium or Platinum plugs, the ACCEL HP plugs are capable
  • Machine rolled threads for precise thread engagement
  • One step colder than stock
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NGK – G-Power Spark Plug (TR5GP): Enhanced Durability & Fuel Efficiency (Part No.3186)

G-Power Spark Plug (TR5GP): Enhanced Durability & Fuel Efficiency

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$8.49
NGK G-Power Platinum spark plugs are the best single platinum spark plugs at an economical price. G-Power plugs feature a fine wire platinum center electrode and a trapezoidal cut ground electrode that offers increased durability, improved fuel efficiency, lower emissions, faster starts and quicker acceleration over conventional nickel spark plugs. An excellent upgrade for vehicles which used nickel alloy spark plugs originally. For better performance consider upgrading to a NGK Iridium IX plug. For even greater performance consider upgrading to a NGK RUTHENIUM HX plug.

Product Features:
  • SINGLE PLATINUM TIP: Fine wire 0.6 millimeter platinum tip center electrode ensures improved durability and a consistently stable spark
  • PLATINUM ALLOY: G-Power platinum provides exceptional value with increased performance and longer service intervals than factory nickel plugs
  • TRAPEZOIDAL CUT GROUND ELECTRODE: Reduces quenching design produces improved ignitability and performance
  • SOLID COPPER CORE: 98% pure copper core offers superior heat dissipation, conductivity and ultra wide heat ranges
  • COLD-ROLLED THREADS: Prevents cross-threading and damage to cylinder heads
  • RECOMMENDED USAGE: Lower cost alternative to double precious metal spark plugs or as an upgrade to OE nickel alloy spark plugs
  • Tapered Seat Type: The tapered seat type ensures a secure fit and optimal performance in compatible vehicles.
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Motorcraft – High-Durability Spark Plug: Reduces Misfires & Fuel Consumption (Part No.SP-526-X)

High-Durability Spark Plug: Reduces Misfires & Fuel Consumption

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$9.99
Motorcraft Spark Plugs are original equipment on Ford Motor Company vehicles, engineered to meet strict Ford engineering standards for performance and reliability. These spark plugs are matched to specific engines to provide enhanced durability, eliminate misfires, reduce fuel consumption, and optimize emissions. They are resistant to oxidation and arc erosion, feature a multi-rib insulator to protect against misfire, and offer service intervals of up to 100,000 miles. Backed by Motorcraft’s Service Parts Warranty, these spark plugs are an exact fit for Ford, Lincoln, and Mercury vehicles and are designed with high-quality materials to provide reliable performance for almost any application. Motorcraft ignition components also help prevent false check engine lights, ensuring your vehicle runs smoothly.

Product Features:
  • Motorcraft spark plugs are matched to specific engines to provide enhanced durability, eliminate misfires, reduce fuel consumption and optimize emissions.
  • Backed by Motorcraft’s Service Parts Warranty
  • Exact fit for Ford, Lincoln and Mercury vehicles
  • Resistant to oxidation and arc erosion.
  • Multi-rib insulator protects against misfire.
  • Service intervals of up to 100,000 miles.
  • Motorcraft Spark Plugs are designed with high quality materials to provide reliable performance for almost any application.
  • Motorcraft Spark Plugs are what was in the vehicle when it was manufactured
  • Motorcraft ignition components help prevent false check engine lights.
  • Engineered for Ford Vehicles: Motorcraft High-Durability Spark Plugs are original equipment on Ford, Lincoln, and Mercury vehicles, ensuring a perfect fit and optimal performance.
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Motorcraft – Double Platinum Spark Plug: Enhanced Durability & Fuel Efficiency (Part No.SP-405)

Double Platinum Spark Plug: Enhanced Durability & Fuel Efficiency

from

$7.29
Motorcraft Spark Plugs are original equipment on Ford Motor Company vehicles, engineered to meet strict Ford engineering standards for performance and reliability. These spark plugs are matched to specific engines to provide enhanced durability, eliminate misfires, reduce fuel consumption, and optimize emissions. With a platinum center and ground electrode tip, they are resistant to oxidation and arc erosion, ensuring long-lasting performance. The multi-rib insulator protects against misfires, and they are backed by Motorcraft’s Service Parts Warranty. Designed for exact fit in Ford, Lincoln, and Mercury vehicles, these spark plugs offer service intervals of up to 100,000 miles and help prevent false check engine lights, making them a reliable choice for almost any application.

Product Features:
  • Motorcraft spark plugs are matched to specific engines to provide enhanced durability, eliminate misfires, reduce fuel consumption and optimize emissions.
  • Backed by Motorcraft’s Service Parts Warranty
  • Exact fit for Ford, Lincoln and Mercury vehicles
  • Resistant to oxidation and arc erosion.
  • Multi-rib insulator protects against misfire.
  • Service intervals of up to 100,000 miles.
  • Motorcraft Spark Plugs are designed with high quality materials to provide reliable performance for almost any application.
  • Motorcraft Spark Plugs are what was in the vehicle when it was manufactured
  • Motorcraft ignition components help prevent false check engine lights.
  • Enhanced Durability: Engineered to meet strict Ford engineering standards, these spark plugs feature a platinum center and ground electrode tip, providing resistance to oxidation and arc erosion for long-lasting performance.
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Champion – Copper Plus Spark Plug (RS9YC): Dependable Performance & Durability (Part No.304)

Copper Plus Spark Plug (RS9YC): Dependable Performance & Durability

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$4.99
Copper Plus spark plug delivers dependable performance and durability, making it an ideal choice for maintaining your vehicle’s efficiency. Featuring a copper core center electrode, it ensures precise heat control for extended lifespan and consistent wear. The nickel-tipped center and ground electrodes enhance conductivity while resisting corrosion, ensuring reliable ignition under various conditions. Designed to meet ISO and SAE Standards, this spark plug guarantees proven performance and compatibility with standard replacement needs. Its tapered seat type and built-in resistor further optimize functionality, making it a trusted solution for smooth engine operation. Invest in this high-quality spark plug for superior reliability and value.

Product Features:
  • Copper core center electrode allows for accurate control of heat range for longer life
  • Built to ISO and SAE standards for proven performance
  • Built to ISO and SAE standards for proven performance
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ACDelco – Double Platinum Spark Plug: Long-Lasting Performance & Durability (Part No.41-814)

Double Platinum Spark Plug: Long-Lasting Performance & Durability

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$10.99
ACDelco Gold (Professional) Double Platinum Spark Plug are a high quality alternative to Original Equipment (OE) parts. With a copper core and double platinum pads on the center electrode, these plugs are designed to deliver long-lasting performance. These premium aftermarket replacement spark plugs are manufactured to meet your expectations for fit, form, and function. ACDelco Gold (Professional) parts are manufactured to meet your expectations for fit, form, and function, making them a smart choice for General Motors vehicles, as well as most makes and models, including special applications. These high-quality parts are backed by General Motors. Some ACDelco Gold parts may have formerly appeared as ACDelco Professional.

Product Features:
  • One-piece, fired-in suppressor seal blends three glass types for a gas-tight seal that helps reduce radio frequency and engine interference, regulate spark plug energy, and protect against compression pressures for long life
  • Double platinum point pad on center and ground electrode offer excellent durability and consistent voltage demands to help reduce wear on ignition system
  • Pure copper core results in cooler electrode temperature for maximized durability and fouling resistance
  • Some ACDelco Gold parts may have formerly appeared as ACDelco Professional
  • Premium aftermarket replacement part
  • Manufactured to meet specifications for fit, form, and function for General Motors vehicles as well as most makes and models
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Motorcraft – Single Lead Spark Plug Wire (Part No.WR-6170)

Single Lead Spark Plug Wire

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$39.99
Motorcraft Single Lead Spark Plug Wires must endure a series of punishing tests including a series of demanding test-to-failure endurance and materials durability tests to ensure their long-lasting quality and operation.

Product Features:
  • The only parts recommended by Ford Motor Company for Ford, Lincoln and Mercury vehicles.
  • Motorcraft ignition system components create and control the electrical functions of engine operation in Ford-built vehicles.
  • The ignition includes the Ignition Coil and modules that generate up to 46,000 volts for spark plug firing as well as the crankshaft position monitor and Power Train Control module or PCM.
  • Motorcraft Ignition components are manufactured to exacting Ford OE specifications and quality standards.
  • As with all Motorcraft aftermarket parts, any engineering innovations or product improvements developed since the vehicle’s manufacture are added to these Ignition components, ensuring the most current technology.
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Most Popular Single Spark Plug Wire for 2022 Ford E-350 Super Duties

Enhance your 2022 Ford E-350 Super Duty with this popular Single Spark Plug Wire we have in stock, for $39.99.

Motorcraft – Single Lead Spark Plug Wire (Part No.WR-6170)

Single Lead Spark Plug Wire

from

$39.99
Motorcraft Single Lead Spark Plug Wires must endure a series of punishing tests including a series of demanding test-to-failure endurance and materials durability tests to ensure their long-lasting quality and operation.

Product Features:
  • The only parts recommended by Ford Motor Company for Ford, Lincoln and Mercury vehicles.
  • Motorcraft ignition system components create and control the electrical functions of engine operation in Ford-built vehicles.
  • The ignition includes the Ignition Coil and modules that generate up to 46,000 volts for spark plug firing as well as the crankshaft position monitor and Power Train Control module or PCM.
  • Motorcraft Ignition components are manufactured to exacting Ford OE specifications and quality standards.
  • As with all Motorcraft aftermarket parts, any engineering innovations or product improvements developed since the vehicle’s manufacture are added to these Ignition components, ensuring the most current technology.
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Best-Selling 2022 Ford E-350 Super Duty Spark Plugs

Upgrade your E-350 Super Duty with one of our 6 best-selling Spark Plugs, earning an average 4.83 stars rating across 218 reviews.

Autolite Iridium – Iridium XP Fine wire Spark Plug: Improved Durability, More Focused Ignition (Part No.XP5363)

Iridium XP Fine wire Spark Plug: Improved Durability, More Focused Ignition

from

$10.99
Autolite has over 100 years of engineering experience and has sold over 11 billion plugs. Designed and engineered in the USA, the Autolite Iridium XP spark plugs feature an iridium-enhanced 0.6mm finewire design and patented platinum sidewire technology to provide better overall durability and a more focused ignition for enhanced ignitability and performance. Features double Iridium-enhanced alloy technology center electrode for improved durability and wear resistance.

Product Features:
  • 0.6 mm finewire design improves ignitability
  • Patented V-trimmed platinum sidewire technology resists wear
  • OE equivalent design is engineered for every engine
  • Designed for better overall durability with virtually no gap erosion
  • Double Iridium-Enhanced Alloy Technology Center Electrode: Offers improved durability and wear resistance for a longer-lasting spark plug.
  • Engineered in the USA: Designed with over 100 years of Autolite’s engineering experience for superior quality and performance.
  • Proven Track Record: Part of a legacy with over 11 billion spark plugs sold, ensuring trusted performance and reliability.
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NGK – Ruthenium HX Spark Plug (LTR7BHX): High Ignitability & Durability (Part No.95605)

Ruthenium HX Spark Plug (LTR7BHX): High Ignitability & Durability

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$14.99
NGK Ruthenium HX High Ignitability spark plugs are the best in class plug for todays modern vehicles. Patented Ruthenium technology offers the most advance tip technology and delivers the highest performance and life expectancy. Created from advanced OE technology as a high ignitability plug, Ruthenium HX spark plugs come with patented, specialized OEM DFE and PSPE tip designs. NGK Ruthenium HX High Ignitability spark plugs provide a more complete fuel burn resulting in a quicker throttle response, smoother idle and better cold starts. Ruthenium center electrode provides industry leading durability.

Product Features:
  • HIGH IGNITABILITY PROJECTED SQUARE PLATINUM ELECTRODE DESIGN: Combines 0.6 millimeter ruthenium center with a unique cut-back PSPE ground electrode
  • RUTHENIUM ALLOY CENTER ELECTRODE: NGK’s patented ruthenium technology produces maximum performance, ignitability & durability at high temperatures
  • PSPE DESIGN: Projected square platinum electrode shape of the ground electrode provides the best ignitability and service life for high heat engines
  • SOLID COPPER CORE: 98% pure copper core offers superior heat dissipation, conductivity and ultra wide heat ranges
  • TRIVALENT METAL PLATING: Delivers superior anti-corrosion and anti-seizing properties, ensuring ease of installation and removal
  • RECOMMENDED USAGE: Modern vehicles using OE PSPE type spark plugs or for those seeking an aftermarket plug with the latest OE technology
  • Enhanced Fuel Burn: Provides a more complete fuel burn, resulting in quicker throttle response, smoother idle, and better cold starts.
  • Industry-Leading Durability: Ruthenium center electrode ensures exceptional durability and longevity.
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E3 – DiamondFIRE Automotive Spark Plug: More Power, Saves Gas (Part No.E3.74)

DiamondFIRE Automotive Spark Plug: More Power, Saves Gas

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$8.49
The Spark Plugs are the product of years of fundamental research in the combustion field. The unique patented electrode configuration of these new The spark plugs increases the amount of combustion pressure created during each power stroke of an engine, which results in a marked increase in power output, fuel economy, and reduced emissions in all gasoline engines. E3.74 is a 14mm, 1.000 reach plug with a taper seat. It fits a wide variety of late model applications, especially Ford applications. The automotive plugs have three legs securing the Diamond FIRE electrode to the shell. This allows for excellent heat transfer, and helps to create more turbulence in the cylinder. The patented Diamond FIRE side wire is proven to increase power, reduce fuel consumption and improve hydrocarbon emissions in long-term use.

Product Features:
  • E3’s Diamond Fire edge to edge ground electrode provides maximum performance with increased efficiency and a faster more complete burn
  • Smoother Acceleration & Idle – The faster flame initiated by the spark plug results in a more complete burn of the ingested fuel charge. More pressure is created against the piston more fuel is put to work
  • Energy – Power output improved up to 6% on average in the typical operating ranges. Results will vary.
  • Efficiency – The “diamond shaped” side wire electrode projects the combustion spark in a way that more quickly ignites the air/fuel mixture, thereby creating a significantly faster and larger flame kernel. The result is that more fuel is put to work durin
  • E3’s patented Diamond Fire Technology provides a cleaner burning combustion, which translates into fuel savings and reduced engine carbon deposits
  • The Spark Plugs are pre-gapped at the factory and cannot be adjusted.
  • Enhanced Heat Transfer: Three legs securing the Diamond FIRE electrode to the shell ensure excellent heat transfer and create more turbulence in the cylinder.
  • Wide Compatibility: The E3.74 spark plug is a 14mm, 1.000 reach plug with a taper seat, fitting a wide variety of late model applications, especially Ford vehicles.
  • Eco-Friendly Performance: Proven to reduce fuel consumption and improve hydrocarbon emissions, contributing to a cleaner environment.
  • Long-Term Efficiency: The Diamond FIRE side wire is designed for long-term use, maintaining increased power and reduced fuel consumption over time.
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Autolite Iridium – Iridium Ultra Fine Wire Spark Plug: Laser Welded for Optimum Performance (Part No.AI5363)

Iridium Ultra Fine Wire Spark Plug: Laser Welded for Optimum Performance

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$10.99
Autolite Iridium Ultra Laser Fine wire Spark Plugs are one of our brand’s most technologically advanced products. These spark plugs provide superior durability, more focused ignition with better overall ignitability for optimum performance. Autolite Spark Plugs are the best alternative to OE spark plugs, offering OE fit form and function supporting all foreign and domestic makes and models at a value price. Autolite provides the automotive aftermarket and original equipment manufacturers with the highest quality ignition products and is the leading supplier of spark plugs in the world.

Product Features:
  • Autolite Iridium Ultra is an engineered OE replacement iridium spark plug.
  • A laser-welded 0.5mm pure iridium finewire center electrode provides optimal fuel efficiency, acceleration and focused ignitability.
  • Nickel-plated shell to resist corrosion.
  • High-alumina ceramic insulator for increased strength.
  • Laser welded 0.5mm Iridium finewire center electrode.
  • Proprietary platinum sidewire technology.
  • Superior Durability: Autolite Iridium Ultra Laser Fine wire Spark Plugs are designed to last longer, providing extended service life compared to standard spark plugs.
  • OE Fit and Function: Autolite Spark Plugs are the best alternative to original equipment (OE) spark plugs, offering perfect fit, form, and function for all foreign and domestic makes and models.
  • High-Quality Construction: As a leading supplier of spark plugs globally, Autolite ensures the highest quality ignition products for both the automotive aftermarket and original equipment manufacturers.
  • Value Pricing: Despite their advanced technology and superior performance, Autolite Iridium Ultra Laser Fine wire Spark Plugs are available at a value price, making them an economical choice for vehicle maintenance.
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NGK – Laser Platinum Spark Plug (LTR7CP13): Fine Wire Tip for High Ignitability (Part No.94862)

Laser Platinum Spark Plug (LTR7CP13): Fine Wire Tip for High Ignitability

from

$18.99
NGK Laser Platinum spark plugs provide high ignitability and longer service life compared to conventional nickel spark plugs. Laser Platinum plugs are tested to the highest standards to ensure quality and durability. Engineered specifically for OE applications. Laser platinum plugs provide stable idling, superior anti-fouling, improved fuel efficiency and lower emissions. High-grade pure alumina ceramic and 98% pure copper core prevents spark plug from overheating and provides reliable starts. Most Laser Platinum spark plugs feature a platinum pad on the ground electrode for even wear in distributorless ignition systems.

Product Features:
  • ACTUAL OE or EQUIVALENT DESIGN: OEM quality construction fine wire platinum alloy center electrode provides consistent performance
  • PLATINUM ALLOY CENTER ELECTRODE: Longer wearing and higher temperature resistance compared to traditional nickel spark plugs
  • PLATINUM TIP GROUND ELECTRODE: Unless OE specified, platinum protection at the ground electrode provides excellent ignitability and service life
  • SOLID COPPER CORE: 98% pure copper core offers superior heat dissipation, conductivity and ultra wide heat ranges
  • TRIVALENT METAL PLATING: Delivers superior anti-corrosion and anti-seizing properties, ensuring ease of installation and removal
  • RECOMMENDED USAGE: Best for vehicles with OE fine wire platinum alloy plugs
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Motorcraft – High-Performance Spark Plug: Enhances Fuel Efficiency (Part No.SP-589)

High-Performance Spark Plug: Enhances Fuel Efficiency

from

$7.99
The Motorcraft High-Performance Spark Plug is expertly crafted to deliver superior ignition performance and optimize fuel efficiency, ensuring reliable starts and smoother engine operation. Featuring a standard center electrode design with an iridium tip and a nickel ground electrode tip, this spark plug is built for exceptional durability and long-lasting performance. Its tapered seat type ensures a secure fit, making it a dependable choice for maintaining your vehicle’s peak performance. Designed to enhance engine responsiveness and improve overall fuel economy, this spark plug is an excellent upgrade for drivers seeking consistent and efficient performance. With precision engineering and high-quality materials, the Motorcraft High-Performance Spark Plug offers unmatched value, helping you save on fuel costs while keeping your engine running at its best.

Product Features:
  • Enhances Fuel Efficiency: The Motorcraft High-Performance Spark Plug is specifically designed to optimize fuel efficiency, helping you save on fuel costs.
  • Superior Ignition Performance: Engineered for superior ignition performance, this spark plug ensures reliable starts every time.
  • Exceptional Durability: Crafted with precision, the Motorcraft High-Performance Spark Plug offers exceptional durability, providing long-lasting performance.
  • Consistent Performance: This spark plug delivers consistent performance, making it an ideal choice for maintaining your vehicle’s peak performance.
  • Improved Engine Responsiveness: Upgrade to Motorcraft and experience a noticeable difference in your engine’s responsiveness and overall fuel economy.
  • Enhances Fuel Efficiency: The Motorcraft High-Performance Spark Plug is specifically designed to optimize fuel efficiency, helping you save on fuel costs.
  • Superior Ignition Performance: Engineered for superior ignition performance, this spark plug ensures reliable starts every time.
  • Exceptional Durability: Crafted with precision, the Motorcraft High-Performance Spark Plug offers exceptional durability, providing long-lasting performance.
  • Consistent Performance: This spark plug delivers consistent performance, making it an ideal choice for maintaining your vehicle’s peak performance.
  • Improved Engine Responsiveness: Upgrade to Motorcraft and experience a noticeable difference in your engine’s responsiveness and overall fuel economy.
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Top-Rated Spark Plug Brands For Your 2022 Ford E-350 Super Duty

When it comes to finding the perfect Spark Plug for your 2022 Ford E-350 Super Duty, Advance Auto Parts has you covered with a wide selection of high-quality OEM and aftermarket options from 4 trusted brands. We carry the most popular Spark Plug brands including NGK, Autolite, and E3, and more, all known for their exceptional customer ratings (average brand rating of 4.8 stars) and competitive prices, as low as $8.49. Purchasing a Spark Plug from us here at Advance Auto Parts is a smart move for both you and your 2022 Ford E-350 Super Duty, providing peace of mind with parts that meet or exceed OEM standards.

Popular NGK 2022 Ford E-350 Super Duty Spark Plugs

If you’re looking for a top-quality Spark Plug for your 2022 Ford E-350 Super Duty, Advance Auto Parts has exactly what you need with our selection of NGK Spark Plugs. We have 1 NGK Spark Plugs in stock for this fitment, all known for their durability and precision fit. With prices starting at just $14.99, you’ll find the perfect Spark Plug for your needs and budget. NGK Spark Plugs for the 2022 Ford E-350 Super Duty come highly rated, with over 1 customer reviews and an impressive average rating of 4.8 stars. Choosing a NGK Spark Plug from Advance Auto Parts is a smart move to ensure quality and value for your vehicle.
Ruthenium HX Spark Plug (LTR7BHX): High Ignitability & Durability
from $14.99
(1)
Ruthenium HX Spark Plug (LTR7BHX): High Ignitability & Durability
“I got these for my 2019 Mustang Ecoboost and these were way better spark plugs then anything i have tried definitely a performance oriented, spark plu”

Top-Quality Autolite 2022 Ford E-350 Super Duty Spark Plugs

For those in search of a high-quality Spark Plug for their 2022 Ford E-350 Super Duty, Advance Auto Parts offers a great selection of Autolite Spark Plugs. With 1 Autolite Spark Plugs in stock, you can trust you’re getting top-tier parts designed for durability and a perfect fit. Prices for these Spark Plugs start at just $10.99, giving you a range of options to suit your budget. Backed by over 41 customer ratings and an average rating of 4.6 stars, Autolite Spark Plugs provide both reliability and excellent performance. Choosing a Autolite Spark Plug from Advance Auto Parts is a smart investment in your vehicle’s performance and longevity.
Iridium XP Fine wire Spark Plug: Improved Durability, More Focused Ignition
from $10.99
(41)
Iridium XP Fine wire Spark Plug: Improved Durability, More Focused Ignition
“Awesome quality plug and a decent price.”

FAQs for 2022 Ford E-350 Super Duty Spark Plugs

What are the best-selling Spark Plugs for 2022 Ford E-350 Super Duties?

Out of 7 Spark Plugs that fit 2022 Ford E-350 Super Duties, the following parts are the top sellers:

What’s the price range for 2022 Ford E-350 Super Duty Spark Plugs?

The prices of Spark Plugs for the 2022 Ford E-350 Super Duty range from $7.99 up to $39.99 for the most premium parts.

What is the average price of a Spark Plug for a 2022 Ford E-350 Super Duty?

The average price for Spark Plugs for the 2022 Ford E-350 Super Duty is $16.06. Keep in mind the variety of part types within our Spark Plug category, where you are likely to find a wide range of prices across a variety of parts and components.

Does Advance Auto Parts sell Spark Plugs for other Ford E-350 Super Duty model years?

Yes, we carry Spark Plugs for 24 model years of Ford E-350 Super Duties between 2000 and 2026. The following model years are the most popular for Spark Plug purchases: 2023, 2024, 2021, 2019, 2018, 2017, 2016, 2015, and 2014.

What are the cheapest Spark Plugs for my 2022 Ford E-350 Super Duty?

Does Advance Auto Parts sell Spark Plugs for any other 2022 Ford models?

Yes. We stock Spark Plugs for 22 other popular 2022 Ford models. Some of the most popular are 2022 F-150 Spark Plugs, 2022 Mustang Spark Plugs, 2022 Explorer Spark Plugs, 2022 Bronco Spark Plugs, and 2022 F-250 Super Duty Spark Plugs.

What are the top-rated Spark Plugs that fit the 2022 Ford E-350 Super Duty?

The one 2022 Ford E-350 Super Duty Spark Plug we have in stock is the High-Performance Spark Plug: Enhances Fuel Efficiency. It costs $7.99.

What types of Spark Plugs do you sell for my 2022 Ford E-350 Super Duty?

As of 11/2/25, these are some of the most in-demand types of Spark Plugs for a 2022 Ford E-350 Super Duty:

Can I get help with 2022 Ford E-350 Super Duty Spark Plug orders?

Contact our customer support team by chat or phone, through the help desk page, where you can find instant answers about Ford Spark Plugs and more.

What is your return policy for Ford E-350 Super Duty Spark Plugs?

Advance Auto Parts keeps returns simple. For new Ford E-350 Super Duty Spark Plugs and accessories, your online orders can be returned, in their original condition, within 45 days. For requirements, see the returns page.