2021 Lexus IS350 Cooling and Climate Controls

Essential Cooling and Climate Controls for 2021 Lexus IS350s

Carquest Premium – Engine Coolant Reservoir Cap (Part No.10254)

Engine Coolant Reservoir Cap

from

$10.99
Manufactured to meet all OEM specifications. Designed to be easy to install and remove. Manufactured from high quality components with proper relief and vacuum valves. Quality tested to stand up to even the most demanding automotive cooling systems.

Product Features:
  • Maintains proper cooling system pressure
  • Easy installation and removal
  • 100% tested to ensure proper pressure and longevity
  • Meets all OEM specifications
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Carquest Premium – Radiator Cap: 16 PSI (Part No.10242)

Radiator Cap: 16 PSI

from

$16.99
Crafted to meet the exact specifications set by Original Equipment Manufacturers (OEM), these products are engineered for effortless installation and removal. Constructed from premium-grade components, incorporating proper relief and vacuum valves, they ensure optimal performance even in the most demanding automotive cooling systems. Rigorously quality-tested, these components provide exceptional, out-of-the-box performance and superior durability to meet or exceed the highest standards of today’s vehicles.

Product Features:
  • Maintains proper cooling system pressure
  • Easy installation and removal
  • 100% tested to ensure proper pressure and longevity
  • Meets all OEM specifications
See More

Dorman – Radiator Fan Assembly: Dual, Cost Effective and Reliable (Part No.620-498)

Radiator Fan Assembly: Dual, Cost Effective and Reliable

from

$453.99
This engine cooling fan assembly is precision-engineered to match the fit and performance of the stock radiator fan on specific vehicle years, makes and models. It has been rigorously tested to ensure it cools as effectively as the original part.

Product Features:
  • Ideal replacement – this engine cooling fan assembly was precision-engineered to match the fit and performance of the stock radiator fan assembly on specific vehicles
  • Complete package – assembly is designed with the same materials and components as the original part
  • Quality assured – motors are tested in laboratory settings to ensure performance
  • Cost effective and reliable – trustworthy manufacturing for far less than same part at the dealership
See More

Dorman – Radiator Fan Assembly: Dual, Cost Effective and Reliable (Part No.620-576)

Radiator Fan Assembly: Dual, Cost Effective and Reliable

from

$541.99
This engine cooling fan assembly is precision-engineered to match the fit and performance of the stock radiator fan on specific vehicle years, makes and models. It has been rigorously tested to ensure it cools as effectively as the original part.

Product Features:
  • Ideal replacement – this engine cooling fan assembly was precision-engineered to match the fit and performance of the stock radiator fan assembly on specific vehicles
  • Complete package – assembly is designed with the same materials and components as the original part
  • Quality assured – motors are tested in laboratory settings to ensure performance
  • Cost effective and reliable – trustworthy manufacturing for far less than same part at the dealership
See More

Carquest Premium – Coolant Temperature Sensor 1TS1172 (Part No.WTC2071)

Coolant Temperature Sensor 1TS1172

from

$65.99
Product Features:
  • Designed to meet or exceed OE specifications for fit, form and function
  • 100% factory resistance calibrated to ensure precision tolerances, resulting in extremely accurate temperature for optimal performance
  • OE precision matched thermistor ensuring Carquest sensors match OE output resistances across all temperature positions
  • O-rings, seals or thread sealant are included if required
  • Weather-tight connectors prevent leaks and corrosion for longer life
  • Extensive design validation testing and 100% end-of-line tested
  • Carquest Vehicle Solutions Technical Support available from ASE certified technicians: 1-866-687-5413
See More

AISIN – TEMPERATURE SENSOR (Part No.THSAZ-8003)

TEMPERATURE SENSOR

from

$48.99
TEMPERATURE SENSOR

DENSO – Engine Coolant Temperature Sensor (Part No.193-1000)

Engine Coolant Temperature Sensor

from

$99.99
DENSO’s engine coolant temperatures sensors are manufactured to the strictest OE standards resulting in superior efficiency. OE quality with precise sensing elements. Exact fit which controls fuel injection ignition timing and transmission shifting.

Product Features:
  • OE technology adapted for the aftermarket
  • Reduces emissions, increased performance
  • Delivers the highest reliability and detection accuracy
See More

Factory Air – Coolant Temp Sensor Switch (Part No.36424)

Coolant Temp Sensor Switch

from

$34.05
High quality OE replacement part with all components needed to complete the job

Product Features:
  • Contains gaskets, O-rings, or seals to properly replace the product
  • Brass construction for accurate temperature sensing
  • Color coded for easy identification
  • Zinc coated terminal to resist corrosion
See More

Carquest Premium – A/C Desiccant Bag Kit (Part No.T83029)

A/C Desiccant Bag Kit

from

$43.99
Carquest Accumulators and Receiver Driers are designed to store, filter and dry the air conditioning refrigerant to provide proper performance and durability for the air conditioning system. They are manufactured to meet or exceed original equipment specifications.

Product Features:
  • All parts meet or exceed original equipment standards for moisture absorption, pressure and temperature resistance, air tightness, vibration resistance, corrosiveness, and pulse pressure.
  • Desiccant is 100% tested and assembled in a controlled environment to ensure performance meets or exceeds original equipment standards.
  • All accumulators and receiver driers are helium leak tested prior to packaging.
  • O-Rings necessary for installation are included.
See More

Carquest Premium – A/C Desiccant Bag Kit (Part No.T83233)

A/C Desiccant Bag Kit

from

$23.99
Carquest Accumulators and Receiver Driers are designed to store, filter and dry the air conditioning refrigerant to provide proper performance and durability for the air conditioning system. They are manufactured to meet or exceed original equipment specifications.

Product Features:
  • All parts meet or exceed original equipment standards for moisture absorption, pressure and temperature resistance, air tightness, vibration resistance, corrosiveness, and pulse pressure.
  • Desiccant is 100% tested and assembled in a controlled environment to ensure performance meets or exceeds original equipment standards.
  • All accumulators and receiver driers are helium leak tested prior to packaging.
  • O-Rings necessary for installation are included.
See More

KAI – A/C Desiccant Element (Part No.ARD010152)

A/C Desiccant Element

from

$10.99
New Standard Replacement A/C Receiver Drier/Desiccant Element

Product Features:
  • Meets All Federal Motor Safety Standards
  • No Drilling Needed For Installation
  • No Modifications Needed For Installation
  • Direct Fit Replacement For Your Vehicle
  • Same Form Fit And Function As OE
  • Check Out The Large Selection Of Parts Available For Your Vehicle
See More

KAI – A/C Desiccant Element (Part No.ACM010005)

A/C Desiccant Element

from

$17.99
New Standard Replacement A/C Receiver Drier And Desiccant Element

Product Features:
  • Meets All Federal Motor Safety Standards
  • No Drilling Needed For Installation
  • No Modifications Needed For Installation
  • Direct Fit Replacement For Your Vehicle
  • Same Form Fit And Function As OE
  • Check Out The Large Selection Of Parts Available For Your Vehicle
See More

Carquest Premium – New Compressor (Part No.T168367)

New Compressor

from

$511.99
New Compressors come pre-charged with 3 ounces of PAG oil for R134a or R1234yf applications.

Product Features:
  • Every unit is 100% function and leak tested
  • Tested for noise, vibration, durability, vacuum decay and pressure decay to ensure no leaks and longer life
  • Very low friction coating used on swash plate to improve durability
  • PTFE coated pistons improve performance and reduce wear
  • Rubber dampened clutch plate ensures smooth clutch engagement and reduces wear
  • Matched high-quality needle-roller bearing ensures low friction and high load capability
  • Limited Warranty when following warranty requirements: Flush A/C System, replace accumulator/receiver dryer, replace orifice tube/expansion device, and filling with correct oil and refrigerant
  • New Compressors meet or exceed OE specifications
  • New Compressors are validated for the equivalent of 100,000 miles
  • New Compressors come pre-charged with 3 ounces of PAG oil for R134a or R1234yf applications
  • New Compressors come with direct fit connectors for ease of installation and to help eliminate splicing
  • New Compressors come with the R12/R134A/1234yf required O-rings /sealing washers to install the compressor
See More

Carquest Standard – Reman Nippondenso 7SAS17C Compressor w/ Clutch (Part No.DW167348)

Reman Nippondenso 7SAS17C Compressor w/ Clutch

from

$242.99
Our products are engineered and tested to provide years of trouble free operation. Backed by over 50 years of mobile a/c experience, fix it once and fix it right with Carquest.

Product Features:
  • Remanufactured compressors are 100 percent tested to ensure compressor function and noise level meets or exceeds OE specifications
  • Remanufactured compressors come pre-charged with 3 ounces of PAG oil for R134a or R1234yf applications
  • Remanufactured compressors are individually vacuum and pressure tested to ensure no leaks
  • Remanufactured compressors come with the R12/R134A/1234yf required O-rings /sealing washers to install the compressor
  • Remanufactured Compressors are built in a ISO9001:2015 Certified facility to ensure consistent quality standards in the Re-manufacturing process
  • Remanufactured compressors are 100 percent tested to ensure compressor function and noise level meets or exceeds OE specifications
  • Remanufactured compressors come pre-charged with 3 ounces of PAG oil for R134a or R1234yf applications
  • Remanufactured compressors are individually vacuum and pressure tested to ensure no leaks
  • Remanufactured compressors come with the R12/R134A/1234yf required O-rings /sealing washers to install the compressor
  • Remanufactured Compressors are built in a ISO9001:2015 Certified facility to ensure consistent quality standards in the Re-manufacturing process
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DENSO – A/C Compressor with Clutch – New (Part No.471-1569)

A/C Compressor with Clutch - New

from

$718.99
As one of the world’s largest OE suppliers of A/C compressors DENSO units are specified by most major vehicle manufacturers. DENSO First Time Fit A/C compressors are manufactured and tested to the strictest OE standards for unparalleled performance. At DENSO we bring together everything we know as an air conditioning systems manufacturer to bring you the highest quality line of factory-new compressors available. When it comes to new compressors you can’t do better than going with a unit manufactured by the OE supplier. At DENSO we know these units better than anyone because we originally designed them. Our compressors are built to meet DENSO’s unsurpassed reputation for technological superiority. You can relax knowing DENSO will give you the right part and the right fit the first time.

Product Features:
  • DENSO is the world’s largest OE supplier of A/C compressors
  • Each compressor is precision manufactured for exact replacement
  • Designed for high output and extended durability
  • Highest quality in the Aftermarket
See More

Carquest Premium – New Compressor with Clutch, Nippondenso 6SBU16C (Part No.T158347)

New Compressor with Clutch, Nippondenso 6SBU16C

from

$694.99
New Compressors come pre-charged with 3 ounces of PAG oil for R134a or R1234yf applications.

Product Features:
  • All compressors go through sophisticated testing and leak test processes
  • Includes specific electrical connector to eliminate splicing
  • For ease of installation this compressor includes all gaskets, O-rings or sealing washers needed to repair your car
  • Validated for fit, form, and function to OE standards
  • New Compressors meet or exceed OE specifications
  • New Compressors are validated for the equivalent of 100,000 miles
  • New Compressors come pre-charged with 3 ounces of PAG oil for R134a or R1234yf applications
  • New Compressors come with direct fit connectors for ease of installation and to help eliminate splicing
  • New Compressors come with the R12/R134A/1234yf required O-rings /sealing washers to install the compressor
See More

Carquest Premium – Blower Motor: With Wheel (Part No.76501)

Blower Motor: With Wheel

from

$165.99
Carquest Premium Blower Motors are engineered and tested to provide years of trouble free operation. Backed by over 50 years of mobile A/C experience, fix it once and fix it right with Carquest Premium Blower Motors. Meets or exceeds OE design. Magnetic size and properties compare or exceed OEM. Windings meet or exceed OEM Specifications. Motor RPM equivalent to or exceeds OEM motor.

Product Features:
  • Meets or exceeds OE design and performance
  • Magnetic size and properties compare or exceed OEM
  • Windings meet or exceed OEM specifications
  • Motor RPM equivalent to or exceeds OEM motor
  • Functionally Equivalent to OE Design
  • Each unit is 100% tested for functional performance and operational noise
  • Hermetically Sealed & Thermally Protected Electronics
See More

Carquest Premium – Blower Motor: With Wheel (Part No.76526)

Blower Motor: With Wheel

from

$347.99
Carquest Premium Blower Motors are engineered and tested to provide years of trouble free operation. Backed by over 50 years of mobile A/C experience, fix it once and fix it right with Carquest Premium Blower Motors. Meets or exceeds OE design. Magnetic size and properties compare or exceed OEM. Windings meet or exceed OEM Specifications. Motor RPM equivalent to or exceeds OEM motor.

Product Features:
  • Meets or exceeds OE design and performance
  • Magnetic size and properties compare or exceed OEM
  • Windings meet or exceed OEM specifications
  • Motor RPM equivalent to or exceeds OEM motor
  • Functionally Equivalent to OE Design
  • Magnetic size and properties compare or exceed OEM
  • Hermetically Sealed & Thermally Protected Electronics
See More

Carquest Premium – A/C Condenser and Receiver Drier Assembly (Part No.6290)

A/C Condenser and Receiver Drier Assembly

from

$174.99
The Carquest condenser is an integral component of the motor vehicle air conditioning system. This part condenses the refrigerant into a liquid to prepare it for entry into the compressor. The condenser is manufactured according to OEM design specifications to ensure a long life with quality performance. Exact design standards produce a seamless fit into the engine compartment.

Product Features:
  • This is a parallel flow condenser that contains small micro-channels. It is highly recommended that this condenser be replaced if a failure has occurred in the vehicle’s air conditioning system that has resulted in debris contaminating the system.
  • This Carquest condenser has a drier attached to it with an interior desiccant bag which will provide optimal moisture removal in the a/c system to maximize cooling performance.
  • The Carquest condenser production process includes quality driven details such as using zinc-coated tubes and electrostatic paint spray at high temperatures to provide the best corrosion resistance and durability in our condensers.
  • Continuous molds, laser welding machines, semi-automatic assembly stations and other advanced equipment provide quality products.
  • Each condenser uses only the highest quality raw materials including pure aluminum (not substandard or recycled) to provide the highest quality standards from beginning to finished product.
  • All brackets are designed per OEM specifications to ensure strength and reduce vibration and movement.
  • We leak test 100% of our condensers in helium leak test chambers to ensure the product does not leak.
  • Our condensers are manufactured from rigid design standards to fit OEM dimensions.
  • Each condenser design endures a series of tests that includes performance testing, vibration testing, blast testing, and salt spray testing to simulate real world conditions.
  • Each Carquest condenser is packaged using superior box construction. This box is easy to open and seal. Each condenser is packaged in the box with internal protection to keep the part centered and away from the package edges.
See More

KAI – A/C Condenser (Part No.CND4254)

A/C Condenser

from

$72.99
New Platinum Pro A/C Condenser, 14-15 IS350/IS350

Product Features:
  • 14-15 IS350/IS350, Made Of Aluminum
  • Meets All Federal Motor Safety Standards
  • No Drilling Needed For Installation
  • No Modifications Needed For Installation
  • Direct Fit Replacement For Your Vehicle
  • Same Form Fit And Function As OE
  • Check Out The Large Selection Of Parts Available For Your Vehicle
See More

KAI – A/C Condenser (Part No.CNDDPI3523)

A/C Condenser

from

$73.99
New Platinum Pro A/C Condenser

Product Features:
  • Made Of Aluminum
  • Meets All Federal Motor Safety Standards
  • No Drilling Needed For Installation
  • No Modifications Needed For Installation
  • Direct Fit Replacement For Your Vehicle
  • Same Form Fit And Function As OE
  • Check Out The Large Selection Of Parts Available For Your Vehicle
See More

Carquest Premium – A/C Refrigerant Pressure Sensor (Part No.ACA1745)

A/C Refrigerant Pressure Sensor

from

$127.99
The Carquest Premium line of vehicle electronics are designed for OE form, fit and function for both import and domestic vehicles. The A/C Pressure Sensor reports system pressures to the on-board computer, in turn allowing the computer to properly and efficiently control the compressor, fans and system levels. An improperly functioning A/C Pressure Sensor will provide erratic or inaccurate readings to on-board computers severely affecting system performance and function. Without reliable and accurate data from a properly functioning A/C Pressure Sensor, on-board computers are unable to protect the safety of critical components and the system as a whole which can lead to excessive wear and tear on critical components and costly system damage.

Product Features:
  • Designed and manufactured with high quality materials, industry leading electronic components and strict quality controls. Engineered to exceed OE performance and to meet the uncompromising demands of service professionals.
  • Direct fit replacement matches proper OE fit, form, and function and ensures trouble free installation of your A/C Pressure Sensor.
  • All units are helium leak tested on fully automated mass spectrometer equipment before end-of-line testing.
  • All units are tested using automated end-of-line testing equipment that pressurizes the sensor and checks full-spectrum functionality and electrical output to ensure each part meets manufacturing specifications before packaging.
See More

Upgrade your 2021 Lexus IS350 with Top-Quality Cooling and Climate Controls

When it comes to maintaining or upgrading your 2021 Lexus IS350, nothing is more important than using high-quality OEM or aftermarket parts that you can trust. Whether you’re repairing damage to your Lexus or enhancing its overall performance, Cooling and Climate Controls are key to keeping your IS350 functioning at its best. At Advance Auto Parts, we offer a wide selection of 9 Cooling and Climate Controls for the 2021 Lexus IS350, designed to meet your needs without breaking the bank. From Blower Motor and Related Product replacements to Air Conditioning Parts upgrades, we’ve got you covered with parts that fit your vehicle perfectly and ensure long-lasting performance.

Affordable Prices and Wide Selection

Shopping for Cooling and Climate Controls for any vehicle can be a hassle, especially if you’re on a budget. But with Advance Auto Parts, you can find high-quality Cooling and Climate Controls for your 2021 Lexus IS350 at great prices. Our Cooling and Climate Controls inventory for this model ranges from just $10.99 to $511.99, with an average price of $213.99. Our 9 Cooling and Climate Controls in stock come from 3 trusted brands, so you’re sure to find the right part for your 2021 Lexus IS350 without overspending.

Top Brands and High Customer Satisfaction

Advance Auto Parts takes pride in offering only the best brands in the automotive industry. For your 2021 Lexus IS350, we stock popular OEM and aftermarket Cooling and Climate Controls from top names like Carquest Premium, and more. Carquest Premium Cooling and Climate Controls start at just $10.99 and boast an impressive 4.4 stars average rating from customers. With 4 customer reviews and counting, our 2021 Lexus IS350 Cooling and Climate Controls have a strong track record of reliability, ensuring you can trust your purchase.

Explore Related Parts and More

While you’re here, don’t forget to check out other essential categories that go hand in hand with Cooling and Climate Control upgrades. Explore related part types like Batteries and Chargers, Oil and Lubricants and more to make sure your 2021 Lexus IS350 is always ready to roll. We’re committed to providing you with everything you need to keep your IS350 in top shape, all in one place. Start shopping confidently below for your 2021 Lexus IS350!

Best-Selling Blower Motor and Related Products for 2021 Lexus IS350s

Enhance the driving experience in your Lexus with 1 quality Blower Motor and Related Product components, starting at $347.99.

Carquest Premium – Blower Motor: With Wheel (Part No.76526)

Blower Motor: With Wheel

from

$347.99
Carquest Premium Blower Motors are engineered and tested to provide years of trouble free operation. Backed by over 50 years of mobile A/C experience, fix it once and fix it right with Carquest Premium Blower Motors. Meets or exceeds OE design. Magnetic size and properties compare or exceed OEM. Windings meet or exceed OEM Specifications. Motor RPM equivalent to or exceeds OEM motor.

Product Features:
  • Meets or exceeds OE design and performance
  • Magnetic size and properties compare or exceed OEM
  • Windings meet or exceed OEM specifications
  • Motor RPM equivalent to or exceeds OEM motor
  • Functionally Equivalent to OE Design
  • Magnetic size and properties compare or exceed OEM
  • Hermetically Sealed & Thermally Protected Electronics
See More

Most Popular 2021 Lexus IS350 Air Conditioning Parts

Customize your Lexus with 4 Air Conditioning Parts products like AC Compressor Without Clutch, AC Condensers, and AC Receiver Drier Desiccant Elements, all priced under $511.99.

Carquest Premium – A/C Refrigerant Pressure Sensor (Part No.ACA1745)

A/C Refrigerant Pressure Sensor

from

$127.99
The Carquest Premium line of vehicle electronics are designed for OE form, fit and function for both import and domestic vehicles. The A/C Pressure Sensor reports system pressures to the on-board computer, in turn allowing the computer to properly and efficiently control the compressor, fans and system levels. An improperly functioning A/C Pressure Sensor will provide erratic or inaccurate readings to on-board computers severely affecting system performance and function. Without reliable and accurate data from a properly functioning A/C Pressure Sensor, on-board computers are unable to protect the safety of critical components and the system as a whole which can lead to excessive wear and tear on critical components and costly system damage.

Product Features:
  • Designed and manufactured with high quality materials, industry leading electronic components and strict quality controls. Engineered to exceed OE performance and to meet the uncompromising demands of service professionals.
  • Direct fit replacement matches proper OE fit, form, and function and ensures trouble free installation of your A/C Pressure Sensor.
  • All units are helium leak tested on fully automated mass spectrometer equipment before end-of-line testing.
  • All units are tested using automated end-of-line testing equipment that pressurizes the sensor and checks full-spectrum functionality and electrical output to ensure each part meets manufacturing specifications before packaging.
See More

Carquest Premium – New Compressor (Part No.T168367)

New Compressor

from

$511.99
New Compressors come pre-charged with 3 ounces of PAG oil for R134a or R1234yf applications.

Product Features:
  • Every unit is 100% function and leak tested
  • Tested for noise, vibration, durability, vacuum decay and pressure decay to ensure no leaks and longer life
  • Very low friction coating used on swash plate to improve durability
  • PTFE coated pistons improve performance and reduce wear
  • Rubber dampened clutch plate ensures smooth clutch engagement and reduces wear
  • Matched high-quality needle-roller bearing ensures low friction and high load capability
  • Limited Warranty when following warranty requirements: Flush A/C System, replace accumulator/receiver dryer, replace orifice tube/expansion device, and filling with correct oil and refrigerant
  • New Compressors meet or exceed OE specifications
  • New Compressors are validated for the equivalent of 100,000 miles
  • New Compressors come pre-charged with 3 ounces of PAG oil for R134a or R1234yf applications
  • New Compressors come with direct fit connectors for ease of installation and to help eliminate splicing
  • New Compressors come with the R12/R134A/1234yf required O-rings /sealing washers to install the compressor
See More

Carquest Premium – A/C Condenser and Receiver Drier Assembly (Part No.710022)

A/C Condenser and Receiver Drier Assembly

from

$333.99
The Carquest condenser is an integral component of the motor vehicle air conditioning system. This part condenses the refrigerant into a liquid to prepare it for entry into the compressor. The condenser is manufactured according to OEM design specifications to ensure a long life with quality performance. Exact design standards produce a seamless fit into the engine compartment.

Product Features:


Product Features:
  • This is a parallel flow condenser that contains small micro-channels. It is highly recommended that this condenser be replaced if a failure has occurred in the vehicle’s air conditioning system that has resulted in debris contaminating.
  • This Carquest condenser has a drier attached to it with an interior desiccant bag which will provide optimal moisture removal in the a/c system to maximize cooling performance.
  • The Carquest condenser production process includes quality driven details such as using zinc-coated tubes and electrostatic paint spray at high temperatures to provide the best corrosion resistance and durability in our condensers.
  • Continuous molds, laser welding machines, semi-automatic assembly stations and other advanced equipment provide quality products.
  • Each condenser uses only the highest quality raw materials including pure aluminum (not substandard or recycled) to provide the highest quality standards from beginning to finished product.
  • All brackets are designed per OEM specifications to ensure strength and reduce vibration and movement.
  • We leak test 100% of our condensers in helium leak test chambers to ensure the product does not leak.
  • Our condensers are manufactured from rigid design standards to fit with OEM dimensions.
  • Each condenser design endures a series of tests that includes performance testing, vibration testing, blast testing, and salt spray testing to simulate real world conditions.
  • Each Carquest condenser is packaged using superior box construction. This box is easy to open and seal. Each condenser is packaged in the box with internal protection to keep the part centered and away from the package edges.
See More

Carquest Premium – A/C Desiccant Bag Kit (Part No.T83233)

A/C Desiccant Bag Kit

from

$23.99
Carquest Accumulators and Receiver Driers are designed to store, filter and dry the air conditioning refrigerant to provide proper performance and durability for the air conditioning system. They are manufactured to meet or exceed original equipment specifications.

Product Features:
  • All parts meet or exceed original equipment standards for moisture absorption, pressure and temperature resistance, air tightness, vibration resistance, corrosiveness, and pulse pressure.
  • Desiccant is 100% tested and assembled in a controlled environment to ensure performance meets or exceeds original equipment standards.
  • All accumulators and receiver driers are helium leak tested prior to packaging.
  • O-Rings necessary for installation are included.
See More

Top Picks for 2021 Lexus IS350 Engine Cooling Parts

Upgrade Lexus IS350s with top-quality Engine Cooling Parts parts, including 4 OEM and aftermarket selections for your 2021 model.

Carquest Premium – Engine Coolant Reservoir Cap (Part No.10254)

Engine Coolant Reservoir Cap

from

$10.99
Manufactured to meet all OEM specifications. Designed to be easy to install and remove. Manufactured from high quality components with proper relief and vacuum valves. Quality tested to stand up to even the most demanding automotive cooling systems.

Product Features:
  • Maintains proper cooling system pressure
  • Easy installation and removal
  • 100% tested to ensure proper pressure and longevity
  • Meets all OEM specifications
See More

Dorman – Radiator Fan Assembly: Dual, Cost Effective and Reliable (Part No.620-498)

Radiator Fan Assembly: Dual, Cost Effective and Reliable

from

$453.99
This engine cooling fan assembly is precision-engineered to match the fit and performance of the stock radiator fan on specific vehicle years, makes and models. It has been rigorously tested to ensure it cools as effectively as the original part.

Product Features:
  • Ideal replacement – this engine cooling fan assembly was precision-engineered to match the fit and performance of the stock radiator fan assembly on specific vehicles
  • Complete package – assembly is designed with the same materials and components as the original part
  • Quality assured – motors are tested in laboratory settings to ensure performance
  • Cost effective and reliable – trustworthy manufacturing for far less than same part at the dealership
See More

Carquest Premium – Coolant Temperature Sensor 1TS1172 (Part No.WTC2071)

Coolant Temperature Sensor 1TS1172

from

$65.99
Product Features:
  • Designed to meet or exceed OE specifications for fit, form and function
  • 100% factory resistance calibrated to ensure precision tolerances, resulting in extremely accurate temperature for optimal performance
  • OE precision matched thermistor ensuring Carquest sensors match OE output resistances across all temperature positions
  • O-rings, seals or thread sealant are included if required
  • Weather-tight connectors prevent leaks and corrosion for longer life
  • Extensive design validation testing and 100% end-of-line tested
  • Carquest Vehicle Solutions Technical Support available from ASE certified technicians: 1-866-687-5413
See More

AISIN – TEMPERATURE SENSOR (Part No.THSAZ-8003)

TEMPERATURE SENSOR

from

$48.99
TEMPERATURE SENSOR

Top-Rated Cooling and Climate Controls Brands For Your 2021 Lexus IS350

Shop for the best-rated brands offering Cooling and Climate Controls and other products for your 2021 Lexus IS350s. Below you’ll find some of our best rated Cooling and Climate Controls from Carquest Premium, and more. Cooling and Climate Controls from these brands that fit a 2021 IS350 start at just $10.99 and are rated as high as 4.4 stars. OEM and aftermarket Cooling and Climate Controls don’t get more top quality, durable, and affordable than from the brands below.

Popular Carquest Premium 2021 Lexus IS350 Cooling and Climate Controls

When it comes to maintaining or upgrading your 2021 Lexus IS350, using quality Cooling and Climate Controls is essential to ensure durability and a perfect fit. Carquest Premium ticks all of those boxes. We offer a wide selection of Carquest Premium Cooling and Climate Controls, specifically designed for the 2021 Lexus IS350. With over 1 Carquest Premium brand Cooling and Climate Controls in stock, you’re sure to find what you need. The prices for these top-notch parts start as low as $10.99. Plus, with over 4 customer reviews and an average rating of 4.4 stars, you can trust that our Carquest Premium Cooling and Climate Controls will get the job done right. Choose Advance Auto Parts for reliability, quality, and expert-approved parts that keep your vehicle running strong.
Engine Coolant Reservoir Cap
from $10.99
(4)
Engine Coolant Reservoir Cap
“I had a difficult time finding a coolant reservoir cap for a Toyota Prius. Advance was the only place in town that carried them.”

FAQs for 2021 Lexus IS350 Cooling and Climate Controls

Which Cooling and Climate Controls are best-sellers for 2021 Lexus IS350s?

Out of 9 Cooling and Climate Controls that fit 2021 Lexus IS350s, the following parts are the top sellers:

What’s the price range for 2021 Lexus IS350 Cooling and Climate Controls?

Cooling and Climate Control prices for the 2021 Lexus IS350 start at $10.99 and go up to $511.99 for the most premium parts.

What’s the average price of a Cooling and Climate Control for a 2021 Lexus IS350?

The average price for Cooling and Climate Controls for the 2021 Lexus IS350 is $213.99. Keep in mind the variety of part types within our Cooling and Climate Control category so you are likely to find a wide range of prices across a variety of parts and components.

Does Advance Auto Parts sell Cooling and Climate Controls for other Lexus IS350 model years?

Yes, we currently carry Cooling and Climate Controls for 18 model years of Lexus IS350s between 2006 and 2025. Cooling and Climate Controls are bought most frequently for the following model years: 2023, 2022, 2020, 2019, 2018, 2017, 2016, 2015, and 2014.

What are the cheapest Cooling and Climate Controls for my 2021 Lexus IS350?

The cheapest 2021 Lexus IS350 Cooling and Climate Controls we carry in stock are:

What are the top-rated Cooling and Climate Controls that fit the 2021 Lexus IS350?

Out of 4 reviews by customers, our 2021 Lexus IS350 Cooling and Climate Controls have an average customer rating of . These are some of the highest-rated Cooling and Climate Control types for the 2021 Lexus IS350 and their top-rated products:

What types of Cooling and Climate Controls do you sell for my 2021 Lexus IS350?

As of 11/2/25, these are some of the most in-demand types of Cooling and Climate Controls for a 2021 Lexus IS350:

Can I get help with 2021 Lexus IS350 Cooling and Climate Control orders?

Contact our customer support team, by chat or phone, through the help desk page, where you can find instant answers about Lexus Cooling and Climate Controls and more.

What is your return policy for Lexus IS350 Cooling and Climate Controls?

Advance Auto Parts keeps returns simple. For new Lexus IS350 Cooling and Climate Controls and accessories, your online orders can be returned, in their original condition, within 45 days. For requirements, see the returns page.