2021 GMC Sierra 2500 HD Drivetrains

Below you will find various in-demand GMC Drivetrains, components and accessories for your 2021 Sierra 2500 HD. Advance Auto Parts has popular Sierra 2500 HD parts like Differentials, Universal Joints, Drive Shafts and Axles and more. You’ll also find aftermarket and OEM Drivetrains for other Sierra 2500 HD model years including 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2022, 2023 and more. Select a category of 2021 GMC Sierra 2500 HD Drivetrains below and start saving instantly.

Popular 2021 GMC Sierra 2500 HD Drivetrains Categories

Differential Oil

U-Joints

Axle Shaft Seals

Transfer Case Output Shaft Seals

Axle Flange Gaskets

Essential Drivetrains for 2021 GMC Sierra 2500 HDs

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$17.99

Ensure a leak-free repair when servicing axle bearings or parking brake shoes. This axle shaft flange seal is a direct replacement for the original gasket and should be replaced every time work is performed at the axle flange.

Product Features:

Ideal replacement – this axle shaft flange seal directly replaces the original gasket without having to visit the dealer.
Required for routine service – this gasket should be replaced every time work is performed at the axle flange.
Durable construction – this axle shaft flange gasket is made of tough, durable materials for leak-free performance
Quality tested – this flange gasket has been designed and tested for a guaranteed fit

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$4.79

Fel-Pro gaskets offer 100% vehicle sealing with application-specific materials to give you sealing solutions with the performance and durability professionals trust

Product Features:

Meets or exceeds all original equipment specifications
Application specific design to ensure a perfect fit
Unsurpassed quality you can trust
Validated for fit, form and function
Each Fel-Pro gasket, no matter how small, is engineered to exacting standards with proprietary design, engineering and manufacturing processes

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$15.99

DRIVEWORKS Universal Joints are designed to meet or exceed OE fit, form, and function. These universal joints are set to provide superior quality and easy installation. DRIVEWORKS Universal Joints are constructed from quality materials for extended durability. DRIVEWORKS Universal Joints are pre-lubricated with premium grease to provide a longer service life. The grease fittings are pre-installed to allow for easy maintenance (where applicable).

Product Features:

The cross is hot forged for the higher torque and horsepower
The bearing cups are made by cold forging, having higher strength and better rigidity
Bearig cups allow 360 lubricant distribution to bearing surfaces, and are precision-ground for maximum load-carrying capabilities
Lubrication grooves designed to ensure grease penetration to entire journal and needle bearings
Grease fitting in the cross allows for easy maintenance and the flexible use of the whole assembly
Snap rings are held to strict tolerances to ensure proper cup position and retention
Nitrile rubber seals to optimize grease retention and reduce contamination

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$106.99

When you see the Spicer name, you know you are buying the highest quality product available. Spicer universal joints are no exception. Dana manufactures a full line of Spicer universal joints that are engineered to ensure longer life for vehicles in a wide variety of applications, from light vehicle to commercial and off-highway.

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$7.19

Universal Joint

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$26.99

Backed by superior materials and rigorous testing, MOOG Premium universal joints deliver reliable performance you can count on. MOOG problem-solving innovations ensure fast, hassle-free installation.

Product Features:

COMPREHENSIVE COVERAGE — Available for foreign and domestic nameplates
GREASABLE DESIGN — Greasable u-joints allow for new grease to flush out contaminants and moisture
KEEPS DIRT OUT — Nitrile rubber grease seals use a compressed double lip design for effective protection against contaminants
RIGOROUS TESTING — Comprehensive testing throughout design and development processes by MOOG engineers for quality you can count on
STRONG AND DURABLE — Bearing cups are cold-forged, case-hardened and precision ground while steel cross is forged and carburized heat treated for strength and durability
Cross forging shape and flash provide easier installation and high strength

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$62.36

Designed and built by GMB to handle the highest loads and excessive torque found in pickups, SUVs, 4x4s and off road vehicles.

Product Features:

Elliptical bearing design delivers reliable performance under the heaviest of loads
Exclusive GMB Ultra-select bearing design exceeds OE specification
Precision finish trunnions and bearing surfaces ensure durability
Proven reliability in off-road conditions and harsh environments

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$41.99

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$28.51

Axle Seal

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$91.57

Timken understands how important seals are in the automotive industry. Leveraging our knowledge and experience with bearings, we offer a broad line of light-duty oil seals made exclusively for Timken in some of the world’s most advanced manufacturing plants.

Product Features:

Machined rubber sealing edge provides greater accuracy and consistency, as well as a better sealing surface.
The flanged design allows for easier and proper installation and helps avoid cocking.
The latex bore coat seals the outer diameter leak path and helps compensate for minor bore imperfections.
Extra dust lip helps keep harmful contaminants, such as dirt, out of the bearing and protects against rust and corrosion.

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$11.99

National has built a reputation as one of the most respected names in the industry. We have offered premium sealing solutions for more than 75 years. Our design team keeps pace with the industry and provides advanced solutions for today’s vehicles.

Product Features:

Low swell in hydrocarbon fluids
Design type: spring loaded; multi-lip
Provides good low temperature capability
Temperature range: -40°F to 225°F; -40°C to 107°C
Delivers quality and reliable performance for every type of repair

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$24.99

GM 9.25 IFS side seal, 1998 & up.Yukon Mighty seal.

Product Features:

Stub axle seal
Fits 1998 and up GM 9.25″ IFS
2.40″ O.D.

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$59.99

GM Genuine Parts Axle Shaft Seals are designed, engineered, and tested to rigorous standards, and are backed by General Motors. These seals help keep dirt and water out of your axle shaft assembly and seal in lubricant. They conform to the rotating surface to help provide leak-free operation. GM Genuine Parts are the true OE parts installed during the production of or validated by General Motors for GM vehicles. Some GM Genuine Parts may have formerly appeared as ACDelco GM Original Equipment (OE).

Product Features:

Helps keep dirt and water out of your axle shaft assembly
Conforms to the rotating surface to help provide leak-free operation
Some GM Genuine Parts may have formerly appeared as ACDelco GM Original Equipment (OE)
GM Genuine Parts are designed, engineered and tested to rigorous standards, and are backed by General Motors
GM Engineers design and validate OE parts specifically for your Chevrolet, Buick, GMC, or Cadillac vehicle
GM regularly updates production and service part designs to integrate new materials and technologies

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$123.99

Wheel Bearing Seal

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$23.99

Product Features:

Brand may vary by location

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$48.49

Low swell in hydrocarbon fluids
Design type: spring loaded; multi-lip
Provides good low temperature capability
Temperature range: -40°F to 225°F; -40°C to 107°C
Delivers quality and reliable performance for every type of repair

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$64.30

AT Rear Seal

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$37.49

Low swell in hydrocarbon fluids
Design type: spring loaded; multi-lip
Provides good low temperature capability
Temperature range: -40°F to 225°F; -40°C to 107°C
Delivers quality and reliable performance for every type of repair

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$39.99

Low swell in hydrocarbon fluids
Design type: spring loaded; multi-lip
Provides good low temperature capability
Temperature range: -40°F to 225°F; -40°C to 107°C
Delivers quality and reliable performance for every type of repair

from

$28.99

Product Features:

Brand may vary by location

from

$32.99

Low swell in hydrocarbon fluids
Design type: spring loaded; multi-lip
Provides good low temperature capability
Temperature range: -40°F to 225°F; -40°C to 107°C
Delivers quality and reliable performance for every type of repair

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$12.49

Valvoline High Performance Synthetic Gear Oil is the thermally stabile extreme pressure lubricant that offers outstanding protection for gearboxes and differentials in passenger cars, light trucks, and sport utility vehicles. Combined with high quality synthetic base oils, our formula’s superior additives help reliably safeguard against severe temperatures, shock loads, foaming, scuffing, scouring, corrosion and pitting in high load, high torque and high horsepower conditions. Can be used in conventional and limited slip hypoid differentials where GL-5 is specified as well as non-synchronized manual transmissions that require GL-4. Protect your gears with Valvoline, the #1 gear oil brand.

Product Features:

HIGH PERFORMANCE EXTREME-PRESSURE ADDITIVES HELP MINIMIZE WEAR in high pressure and high temperature conditions
EXCEPTIONAL HIGH AND LOW TEMPERATURE PROTECTION can easily handle both winter and summer conditions for dependable coverage and protection year-round
REDUCES CHATTERING AND PROTECTS GEAR TEETH from oxidation, rust, and wear
FIGHTS CORROSION AND RUST with emulsifying agents and safeguards against impurities, oxidation and thermal breakdown
SUPERIOR ADDITIVES help reliably safeguard against severe temperatures, shock loads, foaming, scuffing, scouring, corrosion and pitting in high load, high torque and high horsepower conditions

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$12.99

Royal Purple HMX SAE 5W-30 High-Mileage Synthetic Motor Oil, 1 quart is specifically designed to minimize wear and restore lost performance in engines with more than 75,000 miles. Formulated with robust zinc/phosphorus anti-wear compounds combined with Royal Purple’s proprietary additive technology Synerlec, HMX is chemically enhanced to revitalize hardened seals, reducing oil consumption common in high-mileage engines. In addition, HMX is fortified with stout detergents to remove engine build-up and deposits, maintain cleanliness and promote engine longevity.

Product Features:

Specifically designed to minimize wear and restore lost performance in engines with more than 75,000 miles
Formulated with robust zinc/phosphorus anti-wear compounds combined with royal purple’s proprietary additive technology
Hmx is chemically enhanced to revitalize hardened seals, reducing oil consumption common in high-mileage engines
Reduces friction and metal-to-metal contact for peak engine performance
Also provides outstanding oxidation resistance to safely extend oil drain intervals, and an ionic attraction to metal surfaces, providing protection and minimizing wear at start-up
High-Mileage Formula: Specifically designed for engines with more than 75,000 miles, this full synthetic engine oil helps minimize wear and restore lost performance.

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$57.99

3 Qt. Penzoil 80W90 conventional gear Oil. W/ bottle of Posi additive.

Product Features:

Includes three quarts of conventional oil and one 4oz bottle of Yukon positraction additive

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$18.29

Valvoline ULV is a full synthetic, ultra low viscosity transmission fluid specifically engineered for high speed automatic transmissions. Formulated to meet the performance requirements of the latest 9 & 10 speed transmission designs, including the Ford/GM 10R80 found in select Ford F-150 and Raptor trucks.

Product Features:

Formulated with premium synthetic base oils to achieve low viscosity and minimize deposits
Provides excellent thermal and oxidation performance
Durable friction modifiers help prevent shudder
Advanced anti-wear technology to better prevent gear wear

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$137.99

Redline Synthetic “Shock Proof” Oil. 4 Quarts.

Product Features:

Includes four quarts of Redline Shockproof oil

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$35.99

Valvoline DEX/MERC ATF is a high-quality transmission fluid formulated to meet the challenging demands many automatic transmissions. Its responsive low-temperature fluidity is beneficial in both electronic and hydraulic controlled transmissions and transaxles. Recommended for use in the following applications: MERCON®, DEXRON®-III, Ford M2C138-CJ and M2C166-H, Allison C-4 and TES-389, and Caterpillar TO-2.

Product Features:

Formulated with premium base stocks and advanced additive technology to meet the challenging demands of automatic transmissions.
Enhanced anti-shudder protection for smooth shifting and maximum power transfer
Developed with anti-wear technology to help improve transmission durability
Engineered with a proprietary blend of base oils and advanced additives to provide better oil flow at low temperatures and greater film protection at higher temperatures

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$148.99

Redline Synthetic “Shock Proof” Oil with positraction Additive. 4 Quarts.

Product Features:

Includes four quarts of Redline Shockproof oil and one 4oz bottle of Yukon positraction additive

Upgrade your 2021 GMC Sierra 2500 HD with Top-Quality Drivetrains

When it comes to maintaining or upgrading your 2021 GMC Sierra 2500 HD, nothing is more important than using high-quality OEM or aftermarket parts that you can trust. Whether you’re repairing damage to your GMC or enhancing its overall performance, Drivetrains are key to keeping your Sierra 2500 HD functioning at its best. At Advance Auto Parts, we offer a wide selection of 17 Drivetrains for the 2021 GMC Sierra 2500 HD, designed to meet your needs without breaking the bank. From Differential replacements to Universal Joints upgrades, we’ve got you covered with parts that fit your vehicle perfectly and ensure long-lasting performance.

Affordable Prices and Wide Selection

Shopping for Drivetrains for any vehicle can be a hassle, especially if you’re on a budget. But with Advance Auto Parts, you can find high-quality Drivetrains for your 2021 GMC Sierra 2500 HD at great prices. Our Drivetrains inventory for this model ranges from just $8.37 to $62.36, with an average price of $36.47. Our 17 Drivetrains in stock come from 9 trusted brands, so you’re sure to find the right part for your 2021 GMC Sierra 2500 HD without overspending.

Top Brands and High Customer Satisfaction

Advance Auto Parts takes pride in offering only the best brands in the automotive industry. For your 2021 GMC Sierra 2500 HD, we stock popular OEM and aftermarket Drivetrains from top names like Valvoline Royal Purple, and more. Valvoline Drivetrains start at just $12.49 and boast an impressive 5 stars average rating from customers. With 428 customer reviews and counting, our 2021 GMC Sierra 2500 HD Drivetrains have a strong track record of reliability, ensuring you can trust your purchase.

Explore Related Parts and More

While you’re here, don’t forget to check out other essential categories that go hand in hand with Drivetrain upgrades. Explore related part types like Batteries and Chargers, Oil and Lubricants and more to make sure your 2021 GMC Sierra 2500 HD is always ready to roll. We’re committed to providing you with everything you need to keep your Sierra 2500 HD in top shape, all in one place. Start shopping confidently below for your 2021 GMC Sierra 2500 HD!

Best-Selling Differentials for 2021 GMC Sierra 2500 HDs

Enhance the driving experience in your GMC with 4 quality Differential components, starting at $12.49.

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$14.49

Valvoline DEXRON-VI/MERCON LV ATF is a full-synthetic transmission fluid formulated with advanced additive technology to meet and exceed the requirements of the General Motors DEXRON-VI specification. It is officially licensed and approved by GM and is fully back-serviceable and can be used wherever DEXRON-II and/or DEXRON-III are recommended. Recommended for use in the following applications: DEXRON-VI, DEXRON-III, DEXRON-II, and Allison C-4.

Product Features:

Formulated with full-synthetic base stocks and advanced additive technology to meet the challenging demands of automatic transmissions
Enhanced anti-shudder protection for smooth shifting and maximum power transfer
Developed with anti-wear technology to help improve transmission durability
Engineered with a proprietary blend of base oils and advanced additives to provide better oil flow at low temperatures and greater film protection at higher temperatures

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$12.99

High Performance Motor Oil API LICENSED MOTOR OIL Royal Purple High Performance Motor Oil combines premium base oils with proprietary additive technologies to create a high performance synthetic engine oil that optimizes performance and protection. Royal Purple High Performance Motor Oils carry the current API and ILSAC engine oil licenses, as well as the GM dexos1 gasoline engine oil approval. ILSAC GF-6 AND GM DEXOS1 Modern gasoline direct injection (GDI) engines have achieved levels of power and fuel economy never before possible in passenger car engines. As a result, smaller engines operate at much higher loads across all engine speeds. This has caused increased wear in critical areas of the engine, and created a destructive phenomenon called low-speed pre-ignition (LSPI). The unique, state-of-the-art additive technology in Royal Purple High Performance engine oils is designed specifically to address these issues, and help engines maintain performance and reliability.

Product Features:

Better Wear Protection
Increased Protection against Low Speed Pre-Ignition
Increased Fuel Efficiency
Better Protection for Vehicle Exhaust Emissions Equipment
Improved Compatibility with Fuels Containing Ethanol
Superior Corrosion Protection
Made in USA

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$18.29

Formulated with premium synthetic base oils to achieve low viscosity and minimize deposits
Provides excellent thermal and oxidation performance
Durable friction modifiers help prevent shudder
Advanced anti-wear technology to better prevent gear wear

from

$12.49

HIGH PERFORMANCE EXTREME-PRESSURE ADDITIVES HELP MINIMIZE WEAR in high pressure and high temperature conditions
EXCEPTIONAL HIGH AND LOW TEMPERATURE PROTECTION can easily handle both winter and summer conditions for dependable coverage and protection year-round
REDUCES CHATTERING AND PROTECTS GEAR TEETH from oxidation, rust, and wear
FIGHTS CORROSION AND RUST with emulsifying agents and safeguards against impurities, oxidation and thermal breakdown
SUPERIOR ADDITIVES help reliably safeguard against severe temperatures, shock loads, foaming, scuffing, scouring, corrosion and pitting in high load, high torque and high horsepower conditions

Most Popular 2021 GMC Sierra 2500 HD Universal Joints

Customize your GMC with 10 Universal Joints products like U-Joints, all priced under $62.36.

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$54.99

Backed by superior materials and rigorous testing, MOOG Heavy Duty universal joints deliver reliable performance you can count on. MOOG problem-solving innovations ensure fast, hassle-free installation.

Product Features:

BUILT TO LAST — Rugged design specifically engineered for fleets, off-highway and commercial vehicles
STRONG AND DURABLE — Bearing cups are cold-formed, case-hardened and precision ground for strength and durability
KEEPS DIRT OUT — Abrasion-resistant nitrile seals provide ideal grease retention and protection from under-vehicle contaminants
GREASEABLE DESIGN — Drilled and tapped grease fitting holes for easy servicing and cross trunnions with large grease reservoirs with radial grease channels for grease distribution
INHIBITS PREMATURE WEAR — Cross trunnions ground to a 15-25 RMS finish for a smooth surface free of microscopic grooves that can cause premature wear
RELIABLE PERFORMANCE — Internal anti-drainback valve integrated into thrust washer controls lubrication flow and prevents dry startup
RIGOROUS TESTING — Comprehensive testing throughout design and development processes by MOOG engineers for quality you can count on

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$52.99

BUILT TO LAST — Rugged design specifically engineered for fleets, off-highway and commercial vehicles
STRONG AND DURABLE — Bearing cups are cold-formed, case-hardened and precision ground for strength and durability
KEEPS DIRT OUT — Abrasion-resistant nitrile seals provide ideal grease retention and protection from under-vehicle contaminants
GREASEABLE DESIGN — Drilled and tapped grease fitting holes for easy servicing and cross trunnions with large grease reservoirs with radial grease channels for grease distribution
INHIBITS PREMATURE WEAR — Cross trunnions ground to a 15-25 RMS finish for a smooth surface free of microscopic grooves that can cause premature wear
RELIABLE PERFORMANCE — Internal anti-drainback valve integrated into thrust washer controls lubrication flow and prevents dry startup
RIGOROUS TESTING — Comprehensive testing throughout design and development processes by MOOG engineers for quality you can count on

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$54.99

Backed by superior materials and rigorous testing, MOOG Super Strength® universal joints deliver reliable performance you can count on. MOOG problem-solving innovations ensure fast, hassle-free installation.

Product Features:

BUILT TO LAST — Rugged design specifically engineered for applications with higher torque and horsepower
CORROSION PROTECTION — Exclusive MICRO SHIELD coating protects against rust and corrosion
STRONG AND DURABLE — Cold-forged, case-hardened and precision-ground alloy steel crosses for durability
KEEPS DIRT OUT — Abrasion-resistant nitrile seals provide ideal grease retention and protection from under-vehicle contaminants
RIGOROUS TESTING — Comprehensive testing throughout design and development processes by MOOG engineers for quality you can count on
COMPREHENSIVE COVERAGE — Available for foreign and domestic nameplates

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$54.03

Spicer Drivetrain Products light-duty U-joints feature journal crosses that are manufactured from high-quality alloy forgings and heat-treated for maximum life. The bearing cups are case-hardened for strength and durability, while the seals are crafted from nitrile rubber for optimum grease retention and contaminant exclusion. Ample grease reservoirs in each trunnion assure effective lubrication; they’re pre-filled with high-quality synthetic lithium grease, providing superior friction-reduction and resistance to higher temperatures. These replacement universal joints are available for dozens of positions, as well as greasable and non-greasable styles. Order the model designed for fitment with your vehicle and engine type.

Product Features:

Forged cross
Lubeable
O.E.M replacement
Snap rings

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$62.36

Designed and built by GMB to handle the highest loads and excessive torque found in pickups, SUVs, 4x4s and off road vehicles.

Product Features:

Elliptical bearing design delivers reliable performance under the heaviest of loads
Exclusive GMB Ultra-select bearing design exceeds OE specification
Precision finish trunnions and bearing surfaces ensure durability
Proven reliability in off-road conditions and harsh environments

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$55.99

BUILT TO LAST — Rugged design specifically engineered for applications with higher torque and horsepower
CORROSION PROTECTION — Exclusive MICRO SHIELD coating protects against rust and corrosion
STRONG AND DURABLE — Cold-forged, case-hardened and precision-ground alloy steel crosses for durability
KEEPS DIRT OUT — Abrasion-resistant nitrile seals provide ideal grease retention and protection from under-vehicle contaminants
RIGOROUS TESTING — Comprehensive testing throughout design and development processes by MOOG engineers for quality you can count on
COMPREHENSIVE COVERAGE — Available for foreign and domestic nameplates

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$49.45

An ACDelco Professional, premium aftermarket Universal Joint provides pivot points for driveshafts and is the ideal high-quality aftermarket replacement component for many vehicles on the road today. A universal joint is comprised of a pair of hinges connected at a right angle that transmits power between two driveshafts. This premium aftermarket replacement universal joint is manufactured to meet your expectations for fit, form, and function. ACDelco offers a full line of Professional, premium aftermarket Chassis Parts to keep vehicles riding and handling like new. With competitive warranty coverage and products covering all major chassis systems and alignment products for many vehicles on the road today, it’s no wonder the pros rely on ACDelco Professional, premium aftermarket Chassis Parts.

Product Features:

Pivot points for driveshafts in your vehicle
Comprised of a pair of hinges connected at a right angle
Premium, high-quality aftermarket part
Thoroughly engineered to meet or exceed your expectations for fit, form, and function
Provides the performance and dependability you expect from ACDelco

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$38.93

Pivot points for driveshafts in your vehicle
Comprised of a pair of hinges connected at a right angle
Premium, high-quality aftermarket part
Thoroughly engineered to meet or exceed your expectations for fit, form, and function
Provides the performance and dependability you expect from ACDelco

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$28.30

U Joint

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$18.10

U Joint

Top Picks for 2021 GMC Sierra 2500 HD Drive Shafts and Axles

Upgrade GMC Sierra 2500 HDs with top-quality Drive Shafts and Axles parts, including 2 OEM and aftermarket selections for your 2021 model.

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$59.99

Helps keep dirt and water out of your axle shaft assembly
Conforms to the rotating surface to help provide leak-free operation
Some GM Genuine Parts may have formerly appeared as ACDelco GM Original Equipment (OE)
GM Genuine Parts are designed, engineered and tested to rigorous standards, and are backed by General Motors
GM Engineers design and validate OE parts specifically for your Chevrolet, Buick, GMC, or Cadillac vehicle
GM regularly updates production and service part designs to integrate new materials and technologies

from

$17.99

Ideal replacement – this axle shaft flange seal directly replaces the original gasket without having to visit the dealer.
Required for routine service – this gasket should be replaced every time work is performed at the axle flange.
Durable construction – this axle shaft flange gasket is made of tough, durable materials for leak-free performance
Quality tested – this flange gasket has been designed and tested for a guaranteed fit

In-Demand Transfer Cases for 2021 GMC Sierra 2500 HDs

Select from 1 premium Transfer Cases parts for your 2021 GMC Sierra 2500 HD.

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$8.37

AT Extension Housing

Top-Rated Drivetrains Brands For Your 2021 GMC Sierra 2500 HD

Shop for the best-rated brands offering Drivetrains and other products for your 2021 GMC Sierra 2500 HDs. Below you’ll find some of our best rated Drivetrains from Valvoline and Royal Purple, and more. Drivetrains from these brands that fit a 2021 Sierra 2500 HD start at just $12.49 and are rated as high as 5 stars. OEM and aftermarket Drivetrains don’t get more top quality, durable, and affordable than from the brands below.

Popular Valvoline 2021 GMC Sierra 2500 HD Drivetrains

When it comes to maintaining or upgrading your 2021 GMC Sierra 2500 HD, using quality Drivetrains is essential to ensure durability and a perfect fit. Valvoline ticks all of those boxes. We offer a wide selection of Valvoline Drivetrains, specifically designed for the 2021 GMC Sierra 2500 HD. With over 3 Valvoline brand Drivetrains in stock, you’re sure to find what you need. The prices for these top-notch parts start as low as $12.49, with an average price of just $15.09. Plus, with over 2 customer reviews and an average rating of 5 stars, you can trust that our Valvoline Drivetrains will get the job done right. Choose Advance Auto Parts for reliability, quality, and expert-approved parts that keep your vehicle running strong.

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$12.49

This product is not rated

High Performance Transmission & Differential Gear Oil: Conventional 75W-90, 1 Quart

“”

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$14.49

(2)

DEXRON – VI ATF Full Synthetic Automatic Transmission Fluid, 1 Quart

“I’ve used this in my 2005 2500HD since I bought the truck with 20k on it now at 280k changed every other year maybe 40k I’d put on in two years,
I pu”

from
$18.29

This product is not rated

ULV ATF Full Synthetic Ultra Low Viscosity Automatic Transmission Fluid, 1 Quart

“”

Popular Royal Purple 2021 GMC Sierra 2500 HD Drivetrains

Royal Purple auto parts is one of the highest quality Drivetrain brands in the market. Any 2021 GMC Sierra 2500 HD owner should feel confident when installing genuine Royal Purple parts in their vehicle. To ensure the best fit and performance for your 2021 Sierra 2500 HD, Advance Auto Parts carries a full inventory of 1 Royal Purple Drivetrains. Plus you will be keeping your GMC in peak condition while saving money because prices on these Royal Purple Drivetrains range up to $12.99, plus, with more than 82 customer reviews and an impressive 5 stars average rating, you can be confident the Fram Drivetrains below will deliver on both quality and value.

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$12.99

(82)

High Performance SAE 5W30 Synthetic Motor Oil, API Certified, 1 QT

“best oil”

FAQs for 2021 GMC Sierra 2500 HD Drivetrains

Which Drivetrains are best-sellers for 2021 GMC Sierra 2500 HDs?

Out of 17 Drivetrains that fit 2021 GMC Sierra 2500 HDs, the following parts are the top sellers:

DEXRON – VI ATF Full Synthetic Automatic Transmission Fluid, 1 Quart (12079201) – $14.49
Greaseable Premium Universal Joint (10086977) – $54.99
Rear Axle Shaft Seal (11403343) – $59.99

What’s the price range for 2021 GMC Sierra 2500 HD Drivetrains?

Drivetrain prices for the 2021 GMC Sierra 2500 HD start at $8.37 and go up to $62.36 for the most premium parts.

What’s the average price of a Drivetrain for a 2021 GMC Sierra 2500 HD?

The average price for Drivetrains for the 2021 GMC Sierra 2500 HD is $36.47. Keep in mind the variety of part types within our Drivetrain category so you are likely to find a wide range of prices across a variety of parts and components.

Does Advance Auto Parts sell Drivetrains for other GMC Sierra 2500 HD model years?

Yes, we currently carry Drivetrains for 24 model years of GMC Sierra 2500 HDs between 2001 and 2025. Drivetrains are bought most frequently for the following model years: 2023, 2022, 2020, 2019, 2018, 2017, 2016, 2015, and 2014.

What are the cheapest Drivetrains for my 2021 GMC Sierra 2500 HD?

The cheapest 2021 GMC Sierra 2500 HD Drivetrains we carry in stock are:

AT Extension Housing (12094600) – $8.37
High Performance Transmission & Differential Gear Oil: Conventional 75W-90, 1 Quart (11301050) – $12.49
High Performance SAE 5W30 Synthetic Motor Oil, API Certified, 1 QT (8070001) – $12.99
DEXRON – VI ATF Full Synthetic Automatic Transmission Fluid, 1 Quart (12079201) – $14.49
Axle Flange Gasket Kit (12351842) – $17.99

What are the top-rated Drivetrains that fit the 2021 GMC Sierra 2500 HD?

Out of 428 reviews by customers, our 2021 GMC Sierra 2500 HD Drivetrains have an average customer rating of . These are some of the highest-rated Drivetrain types for the 2021 GMC Sierra 2500 HD and their top-rated products:

Differentials
- High Performance SAE 5W30 Synthetic Motor Oil, API Certified, 1 QT (8070001) – $12.99
- DEXRON – VI ATF Full Synthetic Automatic Transmission Fluid, 1 Quart (12079201) – $14.49

What types of Drivetrains do you sell for my 2021 GMC Sierra 2500 HD?

As of 2/5/25, these are some of the most in-demand types of Drivetrains for a 2021 GMC Sierra 2500 HD:

Can I get help with 2021 GMC Sierra 2500 HD Drivetrain orders?

Contact our customer support team, by chat or phone, through the help desk page, where you can find instant answers about GMC Drivetrains and more.

What is your return policy for GMC Sierra 2500 HD Drivetrains?

Advance Auto Parts keeps returns simple. For new GMC Sierra 2500 HD Drivetrains and accessories, your online orders can be returned, in their original condition, within 45 days. For requirements, see the returns page.

2021 GMC Sierra 2500 HD Drivetrains

Dorman – Axle Flange Gasket Kit (Part No.926-573)

Felpro – Drive Axle Shaft Flange Gasket (Part No.55350)

Driveworks – Universal Joint (Part No.DW-235)

Spicer – Universal Joint (Part No.5-3206X)

Neapco – Universal Joint (Part No.2-0054)

MOOG Driveline Products – Greaseable Premium Universal Joint (Part No.534G)

GMB – Universal Joint – Greasable (Part No.K1010222698GMB)

Spicer – Universal Joint (Part No.5-188X)

SKF – Axle Seal (Part No.K4021403278SKF)

Timken – Axle Shaft Seal (Part No.K4021473870TIM)

National – Multi Purpose Seal (Part No.710497)

Yukon Gear – GM 9.25 IFS Side Seal, 1998 & Up (Part No.30161)

GM Genuine Parts – Rear Axle Shaft Seal (Part No.291-336)

Yukon Gear – Wheel Bearing Seal (Part No.30357)

Driveworks – Transfer Case Output Shaft Seal (Part No.S-710496)

National – Multi Purpose Seal (Part No.710495)

ACDelco – AT Rear Seal (Part No.J5071366799ACD)

National – Multi Purpose Seal (Part No.710645)

National – Multi Purpose Seal (Part No.710496)

Driveworks – Transfer Case Output Shaft Seal (Part No.S-710495)

National – Multi Purpose Seal (Part No.710647)

Valvoline – High Performance Transmission & Differential Gear Oil: Conventional 75W-90, 1 Quart (Part No.VV820)

Royal Purple – HMX SAE 5W-30 High-Mileage Synthetic Engine Oil (1 Quart) (Part No.11744)

Yukon Gear – 3 Qt – 80W90 Conventional Gear Oil With Posi Additive (Part No.15003)

Valvoline – ULV ATF Full Synthetic Ultra Low Viscosity Automatic Transmission Fluid, 1 Quart (Part No.888460)

Yukon Gear – Redline Synthetic "Shock Proof" Oil – 4 Quarts (Part No.15004)

Valvoline – DEX/MERC Automatic Transmission Fluid, 1 Gallon (Part No.773636)

Yukon Gear – Redline Synthetic "Shock Proof" Oil With Positraction Additive – 4 Quarts (Part No.15005)

Valvoline – DEXRON – VI ATF Full Synthetic Automatic Transmission Fluid, 1 Quart (Part No.822405)

Royal Purple – High Performance SAE 5W30 Synthetic Motor Oil, API Certified, 1 QT (Part No.01530)

Valvoline – ULV ATF Full Synthetic Ultra Low Viscosity Automatic Transmission Fluid, 1 Quart (Part No.888460)

Valvoline – High Performance Transmission & Differential Gear Oil: Conventional 75W-90, 1 Quart (Part No.VV820)

MOOG Driveline Products – Greaseable Premium Universal Joint (Part No.351)

MOOG Driveline Products – Greaseable Premium Universal Joint (Part No.358)

MOOG Driveline Products – Non-Greaseable Super Strength Universal Joint (Part No.282)

Spicer – Lube For Life Non Greasable U-Joint (Part No.K1010991357SPI)

GMB – Universal Joint – Greasable (Part No.K1010222698GMB)

MOOG Driveline Products – Non-Greaseable Super Strength Universal Joint (Part No.262)

ACDelco – Professional U-Joint (Part No.K1010577100ACD)

ACDelco – Professional U-Joint (Part No.K1010577082ACD)

Autopart International Inc – U Joint (Part No.K10102026981API)

Autopart International Inc – U Joint (Part No.K10102054143API)

GM Genuine Parts – Rear Axle Shaft Seal (Part No.291-336)

Dorman – Axle Flange Gasket Kit (Part No.926-573)

ACDelco – AT Extension Housing (Part No.J5071587500ACD)