2021 GMC Sierra 2500 HD Air Conditioning Parts

Essential 2021 GMC Sierra 2500 HD Air Conditioning Parts

Santech – A/C Service Valve Fi (Part No.R11491515863SII)

A/C Service Valve Fi

from

$3.77
A/C Service Valve Fi

KAI – Valve Core/Cap Kit (Part No.FTT010103)

Valve Core/Cap Kit

from

$12.99
New Standard Replacement A/C System Valve Core And Cap Kit

Product Features:
  • Meets All Federal Motor Safety Standards
  • No Drilling Needed For Installation
  • No Modifications Needed For Installation
  • Direct Fit Replacement For Your Vehicle
  • Same Form Fit And Function As OE
  • Check Out The Large Selection Of Parts Available For Your Vehicle
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Factory Air – Cap & Valve A/C System Seal Kit (Part No.26775)

Cap & Valve A/C System Seal Kit

from

$14.99
High quality OE replacement part with all components needed to complete the job

Product Features:
  • All the seals needed to complete the job
  • Compatible with both R12 and R134a refrigerants
  • SUV and rear air applications
  • Application specific
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KAI – A/C Service Valve (Part No.FJC2576)

A/C Service Valve

from

$10.99
New Standard Replacement 2610 Service Port W/2615 Cap

Product Features:
  • Meets All Federal Motor Safety Standards
  • No Drilling Needed For Installation
  • No Modifications Needed For Installation
  • Direct Fit Replacement For Your Vehicle
  • Same Form Fit And Function As OE
  • Check Out The Large Selection Of Parts Available For Your Vehicle
See More

GM Genuine Parts – Air Conditioning System Valve Core (Part No.15-1119)

Air Conditioning System Valve Core

from

$10.99
GM Genuine Parts A/C System Valve Cores are designed, engineered, and tested to rigorous standards, and are backed by General Motors. These A/C system valve cores are components of the A/C service valve through which your vehicle’s refrigerant can be accessed and serviced. The valve core is a spring-loaded poppet valve that is opened when the service technician connects the A/C service machine hose couplers. GM Genuine Parts are the true OE parts installed during the production of or validated by General Motors for GM vehicles. Some GM Genuine Parts may have formerly appeared as ACDelco GM Original Equipment (OE).

Product Features:
  • Repair leaking A/C system, restore A/C function
  • Helps restore A/C Function
  • Some GM Genuine Parts may have formerly appeared as ACDelco GM Original Equipment (OE)
  • GM Engineers design and validate OE parts specifically for your Chevrolet, Buick, GMC, or Cadillac vehicle
  • Original equipment parts are designed to work with your GM vehicle safety systems — aftermarket replacement parts may not meet the same OE safety regulations, depending on the part type
  • GM regularly updates production and service part designs to integrate new materials and technologies
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GM Genuine Parts – Air Conditioning Service Valve (Part No.15-5438)

Air Conditioning Service Valve

from

$6.99
GM Genuine Parts A/C Service Valves are designed, engineered, and tested to rigorous standards, and are backed by General Motors. These spring-loaded valves allow service access to the A/C system. The service valves allow the service technician to evacuate and recharge the refrigerant in the A/C system. GM Genuine Parts are the true OE parts installed during the production of or validated by General Motors for GM vehicles. Some GM Genuine Parts may have formerly appeared as ACDelco GM Original Equipment (OE).

Product Features:
  • Repairs leaking A/C system
  • Restores A/C function
  • Some GM Genuine Parts may have formerly appeared as ACDelco GM Original Equipment (OE)
  • GM Engineers design and validate OE parts specifically for your Chevrolet, Buick, GMC, or Cadillac vehicle
  • Original equipment parts are designed to work with your GM vehicle safety systems — aftermarket replacement parts may not meet the same OE safety regulations, depending on the part type
  • GM regularly updates production and service part designs to integrate new materials and technologies
See More

ACDelco – A/C Service Valve (Part No.R1129578442ACD)

A/C Service Valve

from

$10.18
A/C Service Valve

ACDelco – A/C Service Valve (Part No.R1129947779ACD)

A/C Service Valve

from

$13.13
A/C Service Valve

Carquest Premium – A/C Premium OEM Improved; New; w/ Clutch; w/ HU6 Compressor (Part No.T58901)

A/C Premium OEM Improved; New; w/ Clutch; w/ HU6 Compressor

from

$296.99
This premium new compressor improves upon the original equipment design by providing two additional pistons and a center seal lip to prevent a center seal leak created by road conditions. CARQUEST New Compressors are designed, manufactured and tested to meet or exceed strict original equipment specifications for superior quality and performance. Each new compressor is tested to provide durable life to the vehicle’s air conditioning system. All new compressor components are assembled using state of the art equipment and techniques to ensure a smooth operation. Each part is equipped with a clutch and connector that matches the original equipment part and provides an exact replacement to your vehicle’s part. All compressors are supplied with the necessary gaskets and o-rings for installation.

Product Features:
  • Each new compressor design undergoes rigorous life cycle testing at high RPMs and pressures to ensure that they can withstand years in the harshest conditions.
  • New compressors are designed with utmost precision using 3D coordinate measuring machines to ensure a perfect fit.
  • The production process contains automated controls at every stage that alerts and halts production in case of an error, assuring that the finished product will always be flawless.
  • All new compressors must pass a helium leak test and pump up function test prior to packaging.
  • O-Rings and gaskets necessary for installation are included.
  • Matched high-quality needle-roller bearing ensures low friction and high load capability.
  • Light weight aluminum energy-saving casting used for construction.
See More

Carquest Standard – Reman Nippondenso 10S17F Compressor w/ Clutch (Part No.DW77362)

Reman Nippondenso 10S17F Compressor w/ Clutch

from

$258.99
Carquest Standard compressors offer reliable, long-lasting performance for a leak-free, dependable repair.

Product Features:
  • Built in a TS16949 certified manufacturing environment to ensure consistent quality that meets or exceeds OE specifications for fit, form, function and durability
  • All remanufactured compressors are built using the latest compressor technology available today and using strict remanufacturing processes
  • All units have new seals, O-rings, gaskets and clutch bearings
  • Tested for noise, vibration, durability, vacuum decay and pressure decay to ensure no leaks and longer life
See More

Carquest Premium – A/C New; w/ Clutch; w/ 10S20F Compressor (Part No.T78363)

A/C New; w/ Clutch; w/ 10S20F Compressor

from

$279.99
Carquest New Compressors are designed, manufactured and tested to meet or exceed strict original equipment specifications for superior quality and performance. Each new compressor is tested to provide durable life to the vehicle’s air conditioning system. All new compressor components are assembled using state of the art equipment and techniques to ensure smooth operation. Each part is equipped with a clutch and connector that matches the original equipment part and provides an exact replacement to your vehicle’s part. All compressors are supplied with the necessary gaskets and o-rings for installation.

Product Features:
  • Each new compressor design undergoes rigorous life cycle testing at high RPMs and pressures to ensure that they can withstand years in the harshest conditions.
  • New compressors are designed with utmost precision using 3D coordinate measuring machines to ensure a perfect fit.
  • The production process contains automated controls at every stage that alerts and halts production in case of an error, assuring that the finished product will always be flawless.
  • All new compressors must pass a helium leak test and pump up function test prior to packaging.
  • O-Rings and gaskets necessary for installation are included.
  • Matched high-quality needle-roller bearing ensures low friction and high load capability.
  • Light weight aluminum energy-saving casting used for construction.
See More

Autopart International Inc – A/C Compressor (Part No.R10003199103API)

A/C Compressor

from

$350.66
A/C Compressor

Delphi – A/C Compressor (Part No.CS20039)

A/C Compressor

from

$274.99
100 years of OE experience, supplier to the world’s top automakers, OE Heritage and knowledge built into every aftermarket part.

Product Features:
  • All Delphi compressors are an exact fit
  • Sealing washers are included (where applicable) with all Delphi compressors and no extra parts to purchase
  • All Delphi compressors are 100% leak tested
  • Delphi compressors are constructed with high-quality corrosion resistant aluminum alloy not often found in aftermarket products
  • Low torque demand results in better engine performance and increased fuel economy
  • All Delphi compressors meet or exceed OE specifications
See More

Carquest Premium – A/C New; w/ Clutch; w/ 10S20F Compressor (Part No.T78362)

A/C New; w/ Clutch; w/ 10S20F Compressor

from

$267.99
Carquest New Compressors are designed, manufactured and tested to meet or exceed strict original equipment specifications for superior quality and performance. Each new compressor is tested to provide durable life to the vehicle’s air conditioning system. All new compressor components are assembled using state of the art equipment and techniques to ensure smooth operation. Each part is equipped with a clutch and connector that matches the original equipment part and provides an exact replacement to your vehicle’s part. All compressors are supplied with the necessary gaskets and o-rings for installation.

Product Features:
  • Each new compressor design undergoes rigorous life cycle testing at high RPMs and pressures to ensure that they can withstand years in the harshest conditions.
  • New compressors are designed with utmost precision using 3D coordinate measuring machines to ensure a perfect fit.
  • The production process contains automated controls at every stage that alerts and halts production in case of an error, assuring that the finished product will always be flawless.
  • All new compressors must pass a helium leak test and pump up function test prior to packaging.
  • O-Rings and gaskets necessary for installation are included.
  • Matched high-quality needle-roller bearing ensures low friction and high load capability.
  • Light weight aluminum energy-saving casting used for construction.
See More

Carquest Standard – Reman Nippondenso 10S17F Compressor w/ Clutch (Part No.DW77348)

Reman Nippondenso 10S17F Compressor w/ Clutch

from

$249.99
Remanufactured Compressors are built in a ISO9001:2015 Certified facility to ensure consistent quality stAndards in the Re-manufacturing process
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KAI – A/C Compressor (Part No.ACP010581)

A/C Compressor

from

$349.99
New Standard Replacement A/C Compressor, H6, 4 Groove, V8 Engine

Product Features:
  • H6, 4 Groove, V8 Engine
  • Meets All Federal Motor Safety Standards
  • No Drilling Needed For Installation
  • No Modifications Needed For Installation
  • Direct Fit Replacement For Your Vehicle
  • Same Form Fit And Function As OE
  • Check Out The Large Selection Of Parts Available For Your Vehicle
See More

Carquest Premium – A/C New; w/ Clutch; w/ 7SAS17F Compressor (Part No.T178363)

A/C New; w/ Clutch; w/ 7SAS17F Compressor

from

$463.99
Carquest New Compressors are designed, manufactured and tested to meet or exceed strict original equipment specifications for superior quality and performance. Each new compressor is tested to provide durable life to the vehicle’s air conditioning system. All new compressor components are assembled using state of the art equipment and techniques to ensure smooth operation. Each part is equipped with a clutch and connector that matches the original equipment part and provides an exact replacement to your vehicle’s part. All compressors are supplied with the necessary gaskets and o-rings for installation.

Product Features:
  • Each new compressor design undergoes rigorous life cycle testing at high RPMs and pressures to ensure that they can withstand years in the harshest conditions.
  • New compressors are designed with utmost precision using 3D coordinate measuring machines to ensure a perfect fit.
  • The production process contains automated controls at every stage that alerts and halts production in case of an error, assuring that the finished product will always be flawless.
  • All new compressors must pass a helium leak test and pump up function test prior to packaging.
  • O-Rings and gaskets necessary for installation are included.
See More

KAI – A/C Compressor, Denso, V8 Engine (Part No.ACP010583)

A/C Compressor, Denso, V8 Engine

from

$302.99
New Standard Replacement A/C Compressor, Denso, V8 Engine

Product Features:
  • Denso, V8 Engine
  • Meets All Federal Motor Safety Standards
  • No Drilling Needed For Installation
  • No Modifications Needed For Installation
  • Direct Fit Replacement For Your Vehicle
  • Same Form Fit And Function As OE
  • Check Out The Large Selection Of Parts Available For Your Vehicle
See More

Carquest Standard – Reman Nippondenso 10S20F Compressor w/ Clutch (Part No.DW77363)

Reman Nippondenso 10S20F Compressor w/ Clutch

from

$314.99
Carquest Standard compressors offer reliable, long-lasting performance for a leak-free, dependable repair.

Product Features:
  • Built in a TS16949 certified manufacturing environment to ensure consistent quality that meets or exceeds OE specifications for fit, form, function and durability
  • All remanufactured compressors are built using the latest compressor technology available today and using strict remanufacturing processes
  • All units have new seals, O-rings, gaskets and clutch bearings
  • Tested for noise, vibration, durability, vacuum decay and pressure decay to ensure no leaks and longer life
See More

Carquest Standard – A/C Remanufactured; w/ Clutch; w/ 10S20F Compressor (Part No.DW77376)

A/C Remanufactured; w/ Clutch; w/ 10S20F Compressor

from

$289.99
Carquest Standard Remanufactured Compressors are manufactured to meet original equipment specifications. All components are either remanufactured to strict standards or are replaced with new components to ensure performance and durability. All compressors are 100% end of line tested.

Product Features:
  • O-Rings and gaskets necessary for installation are included.
  • All remanufactured compressors are built using the latest compressor technology available today and using strict remanufacturing processes
  • All units have new seals, O-rings, gaskets and clutch bearings
  • Tested for noise, vibration, durability, vacuum decay and pressure decay to ensure no leaks and longer life
See More

DENSO – New Compressor With Clutch (Part No.471-0316)

New Compressor With Clutch

from

$419.99
As one of the world+s largest OE suppliers of A/C compressors DENSO units are specified by most major vehicle manufacturers. DENSO First Time Fit A/C compressors are manufactured and tested to the strictest OE standards for unparalleled performance. At DENSO we bring together everything we know as an air conditioning systems manufacturer to bring you the highest quality line of factory-new compressors available. When it comes to new compressors you can’t do better than going with a unit manufactured by the OE supplier. At DENSO we know these units better than anyone because we originally designed them. Our compressors are built to meet DENSO+s unsurpassed reputation for technological superiority. You can relax knowing DENSO will give you the right part and the right fit the first time.

Product Features:
  • DENSO is the world’s largest OE supplier of A/C compressors
  • Each compressor is precision manufactured for exact replacement
  • Designed for high output and extended durability
  • Highest quality in the Aftermarket
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Carquest Premium – A/C New; w/ Clutch; w/ 7SAS17F Compressor (Part No.T168305)

A/C New; w/ Clutch; w/ 7SAS17F Compressor

from

$576.99
Carquest New Compressors are designed, manufactured and tested to meet or exceed strict original equipment specifications for superior quality and performance. Each new compressor is tested to provide durable life to the vehicle’s air conditioning system. All new compressor components are assembled using state of the art equipment and techniques to ensure smooth operation. Each part is equipped with a clutch and connector that matches the original equipment part and provides an exact replacement to your vehicle’s part. All compressors are supplied with the necessary gaskets and o-rings for installation.

Product Features:
  • Each new compressor design undergoes rigorous life cycle testing at high RPMs and pressures to ensure that they can withstand years in the harshest conditions.
  • New compressors are designed with utmost precision using 3D coordinate measuring machines to ensure a perfect fit.
  • The production process contains automated controls at every stage that alerts and halts production in case of an error, assuring that the finished product will always be flawless.
  • All new compressors must pass a helium leak test and pump up function test prior to packaging.
  • O-Rings and gaskets necessary for installation are included.
See More

GM Genuine Parts – Air Conditioning Compressor and Clutch Assembly (Part No.15-20940)

Air Conditioning Compressor and Clutch Assembly

from

$577.99
GM Genuine Parts A/C Compressors are designed, engineered, and tested to rigorous standards, and are backed by General Motors. These compressors pump refrigerant through the system. The compressor is typically engine driven via the accessory belt, and a clutch on the compressor is used to engage and disengage the compressor. Hybrid vehicles are typically equipped with an electric motor driven compressor. The compressor is lubricated by refrigerant oil. GM Genuine Parts are the true OE parts installed during the production of or validated by General Motors for GM vehicles. Some GM Genuine Parts may have formerly appeared as ACDelco GM Original Equipment (OE). Product contains Decabromodiphenyl ether (decaBDE): Not for sale in Washington D.C.

Product Features:
  • Visual and leak-tested to help ensure the component’s quality and durability
  • The oil separator is part of the compressor and removes oil from the refrigerant to help keep system efficiency
  • GM meets an aggressive engineering requirement for compressor clutch durability and corrosion resistance. Together, these help ensure long-term quality and durability
  • Some GM Genuine Parts may have formerly appeared as ACDelco GM Original Equipment (OE)
  • GM Genuine Parts are designed, engineered and tested to rigorous standards, and are backed by General Motors
  • GM Engineers design and validate OE parts specifically for your Chevrolet, Buick, GMC, or Cadillac vehicle
  • GM regularly updates production and service part designs to integrate new materials and technologies
See More

Delphi – A/C Compressor (Part No.CS20011)

A/C Compressor

from

$259.99
100 years of OE experience, supplier to the world’s top automakers, OE Heritage and knowledge built into every aftermarket part.

Product Features:
  • All Delphi compressors are an exact fit
  • Sealing washers are included (where applicable) with all Delphi compressors and no extra parts to purchase
  • All Delphi compressors are 100% leak tested
  • Delphi compressors are constructed with high-quality corrosion resistant aluminum alloy not often found in aftermarket products
  • Low torque demand results in better engine performance and increased fuel economy
  • All Delphi compressors meet or exceed OE specifications
See More

KAI – A/C Compressor (Part No.ACP011417)

A/C Compressor

from

$354.99
New Standard Replacement A/C Compressor, Model 10S17F, 4 Groove, With Switch Port 115MM Clutch Diameter

Product Features:
  • Model 10S17F, 4 Groove, With Switch Port 115MM Clutch Diameter
  • Meets All Federal Motor Safety Standards
  • No Drilling Needed For Installation
  • No Modifications Needed For Installation
  • Direct Fit Replacement For Your Vehicle
  • Same Form Fit And Function As OE
  • Check Out The Large Selection Of Parts Available For Your Vehicle
See More

Carquest Standard – Remanufactured Compressor with Clutch (Part No.DW77377)

Remanufactured Compressor with Clutch

from

$284.99
Carquest Standard compressors offer reliable, long-lasting performance for a leak-free, dependable repair.

Product Features:
  • Built in a TS16949 certified manufacturing environment to ensure consistent quality that meets or exceeds OE specifications for fit, form, function and durability
  • All remanufactured compressors are built using the latest compressor technology available today and using strict remanufacturing processes
  • All units have new seals, O-rings, gaskets and clutch bearings
  • Tested for noise, vibration, durability, vacuum decay and pressure decay to ensure no leaks and longer life
See More

Carquest Premium – A/C New; w/ Clutch; w/ 10SE18 Compressor (Part No.T198353)

A/C New; w/ Clutch; w/ 10SE18 Compressor

from

$294.99
Carquest New Compressors are designed, manufactured and tested to meet or exceed strict original equipment specifications for superior quality and performance. Each new compressor is tested to provide durable life to the vehicle’s air conditioning system. All new compressor components are assembled using state of the art equipment and techniques to ensure smooth operation. Each part is equipped with a clutch and connector that matches the original equipment part and provides an exact replacement to your vehicle’s part. All compressors are supplied with the necessary gaskets and o-rings for installation.

Product Features:
  • Each new compressor design undergoes rigorous life cycle testing at high RPMs and pressures to ensure that they can withstand years in the harshest conditions.
  • New compressors are designed with utmost precision using 3D coordinate measuring machines to ensure a perfect fit.
  • The production process contains automated controls at every stage that alerts and halts production in case of an error, assuring that the finished product will always be flawless.
  • All new compressors must pass a helium leak test and pump up function test prior to packaging.
  • O-Rings and gaskets necessary for installation are included.
  • O-Rings and gaskets necessary for installation are included.
See More

Carquest Premium – A/C New; w/ Clutch; w/ HT6 Compressor (Part No.T88931)

A/C New; w/ Clutch; w/ HT6 Compressor

from

$349.99
Carquest New Compressors are designed, manufactured and tested to meet or exceed strict original equipment specifications for superior quality and performance. Each new compressor is tested to provide durable life to the vehicle’s air conditioning system. All new compressor components are assembled using state of the art equipment and techniques to ensure smooth operation. Each part is equipped with a clutch and connector that matches the original equipment part and provides an exact replacement to your vehicle’s part. All compressors are supplied with the necessary gaskets and o-rings for installation.

Product Features:
  • Each new compressor design undergoes rigorous life cycle testing at high RPMs and pressures to ensure that they can withstand years in the harshest conditions.
  • New compressors are designed with utmost precision using 3D coordinate measuring machines to ensure a perfect fit.
  • The production process contains automated controls at every stage that alerts and halts production in case of an error, assuring that the finished product will always be flawless.
  • All new compressors must pass a helium leak test and pump up function test prior to packaging.
  • O-Rings and gaskets necessary for installation are included.
  • O-Rings and gaskets necessary for installation are included.
See More

2021 GMC Sierra 2500 HD Air Conditioning Parts

Maybe you’re in the middle of a full rebuild of that 2021 GMC Sierra 2500 HD. Maybe you just need a couple of Air Conditioning Parts. Either way, Advance Auto Parts has 5 different Air Conditioning Parts in our inventory ranging from $10.99 to $350.66. That means you can find the exact parts or products you need to keep that 2021 GMC Sierra 2500 HD running smoothly.

Air Conditioning Parts are only as good as their brand. We stock 4 different brands to make sure you have plenty of trusted parts to choose from for your 2021 GMC Sierra 2500 HD. GM Genuine, ACDelco, and Autopart International Inc are just some of the brands we stock. Search for brands you know or compare prices and reviews to help you decide!

We know you’ll find the perfect Air Conditioning Parts for your 2021 GMC Sierra 2500 HD, but don’t take our word for it – read our customer ratings and reviews and buy with confidence.

So if you’re in the market for aftermarket Air Conditioning Parts to keep your 2021 GMC Sierra 2500 HD rolling for years to come, look no further. Shop online and have your products shipped direct to your door, or pick up at the nearest Advance Auto Parts location today!

Air Conditioning Parts Brands To Make Your 2021 GMC Sierra 2500 HD Last

Simple repair, complete replacement, or a full rebuild. No matter the job, your 2021 GMC Sierra 2500 HD demands trusted brand parts and products to keep it running. Many trusted brands of Air Conditioning Parts make up Advance Auto Parts’ inventory, and all are ready to help make your Sierra 2500 HD the best it can be. Be sure to browse some of our top Air Conditioning Parts brands and parts.

Popular GM Genuine Parts Air Conditioning Parts

We carry GM Genuine Parts parts in our stock across AC Caps and Valve Core Kits categories, plus more. For a 2021 GMC Sierra 2500 HD, our most popular GM Genuine Parts Air Conditioning Parts include:
Air Conditioning System Valve Core
from $10.99
(6)
Air Conditioning System Valve Core
AC Caps and Valve Core Kits

FAQs for 2021 GMC Sierra 2500 HD Air Conditioning Parts

What are the most purchased Air Conditioning Parts for the 2021 GMC Sierra 2500 HD?

Out of 5 Air Conditioning Parts for the 2021 GMC Sierra 2500 HD, the most popular in our inventory are:
A/C Compressor
from $350.66
This product is not rated
A/C Compressor
AC Compressor Without Clutch
New; w/ Clutch; w/ 7SAS17A Compressor
from $284.99
This product is not rated
New; w/ Clutch; w/ 7SAS17A Compressor
AC Compressor Without Clutch
A/C Service Valve
from $13.13
This product is not rated
A/C Service Valve
AC Low Side Charging Adapters