2021 Ford E-450 Super Duty Spindles

Keep Your 2021 Ford E-450 Super Duty in Top Shape with Quality Spindles

Whether you’re repairing or upgrading your Spindle, using high-quality parts is key to keeping your 2021 Ford E-450 Super Duty looking sharp and performing at its best. At Advance Auto Parts we carry a wide selection of dependable options, including Spindle Lock Nuts. Whether you’re replacing a damaged part or enhancing your truck’s style and protection, you’ll find exactly what you need to get the job done right.

Top-Rated Spindles from Trusted Brands

Looking for a reliable Spindle? We’ve got you covered with options from brands you know and trust like Dorman. For example, Dorman Spindles start at just $3.49 with an average 4.2 star rating. With over 3 reviews and a solid 5 star average, you can shop with confidence knowing other Ford E-450 Super Duty owners approve.

Competitive Prices and Extensive Inventory

The average price for a 2021 Ford E-450 Super Duty Spindle at Advance Auto Parts is around $22.19, with a range that starts at $3.49 and goes up to $40.49. With 4 options in stock from one trusted brand, finding the right fit is easy. Popular picks like Standard Spindle Nut 3/4 In.-16 Hex Size 1-1/16 In. (sold by each), Spindle Nut 2 In.-16 Hex Size 3 In. (sold by each), and Spindle Nut 2 In.-16 Hex Size 3 In. start at just $4.79 and offer a great balance of form and function.

Explore Related Parts

While you’re upgrading or replacing your Spindle, don’t forget to check out other key components like Differentials and Drive Shafts and Axles. At Advance Auto Parts, we’re here to help you keep your 2021 Ford E-450 Super Duty in peak condition, inside and out.

Essential 2021 Ford E-450 Super Duty Spindles

Dorman – Spindle Nut 2 In.-16 Hex Size 3 In. (Part No.615-133.1)

Spindle Nut 2 In.-16 Hex Size 3 In.

from

$39.99
This spindle nut is designed to match the fit and function of the original part on specified vehicles. Made of quality materials, it is engineered for reliable performance.

Product Features:
  • Direct replacement – this spindle nut matches the fit and function of the factory part on specified years, makes and models
  • Ideal solution – this nut is a reliable replacement for an original part that is missing or has failed due to fatigue
  • Durable construction – this part is made from quality materials to ensure reliable performance and long service life
  • Trustworthy quality – backed by team of product experts in the United States and more than a century of automotive experience
See More

Dorman – Spindle Nut 2 In.-16 Hex Size 3 In. (sold by each) (Part No.615-133)

Spindle Nut 2 In.-16 Hex Size 3 In. (sold by each)

from

$40.49
This spindle nut is designed to match the fit and function of the original part on specified vehicles. Made of quality materials, it is engineered for reliable performance.

Product Features:
  • Direct replacement – this spindle nut matches the fit and function of the factory part on specified years, makes and models
  • Ideal solution – this nut is a reliable replacement for an original part that is missing or has failed due to fatigue
  • Durable construction – this part is made from quality materials to ensure reliable performance and long service life
  • Trustworthy quality – backed by team of product experts in the United States and more than a century of automotive experience
See More

Dorman – Standard Spindle Nut 3/4 In.-16 Hex Size 1-1/16 In. (Part No.615-072.1)

Standard Spindle Nut 3/4 In.-16 Hex Size 1-1/16 In.

from

$3.49
This spindle nut is designed to match the fit and function of the original part on specified vehicles. Made of quality materials, it is engineered for reliable performance.

Product Features:
  • Direct replacement – this spindle nut matches the fit and function of the factory part on specified years, makes and models
  • Ideal solution – this nut is a reliable replacement for an original part that is missing or has failed due to fatigue
  • Durable construction – this part is made from quality materials to ensure reliable performance and long service life
  • Trustworthy quality – backed by team of product experts in the United States and more than a century of automotive experience
See More

Yukon Gear – Spindle Nut, 2.065" I.D., Six Slots (Part No.33484)

Spindle Nut, 2.065" I.D., Six Slots

from

$27.99
Spindle nut, 2.065″ I.D., six slots. This replaces Spicer part number 36635.

Product Features:
  • Spindle nut
  • 6 slots
  • 2.065″ I.D.
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Dorman – Standard Spindle Nut 3/4 In.-16 Hex Size 1-1/16 In. (sold by each) (Part No.615-072)

Standard Spindle Nut 3/4 In.-16 Hex Size 1-1/16 In. (sold by each)

from

$4.79
This spindle nut is designed to match the fit and function of the original part on specified vehicles. Made of quality materials, it is engineered for reliable performance.

Product Features:
  • Direct replacement – this spindle nut matches the fit and function of the factory part on specified years, makes and models
  • Ideal solution – this nut is a reliable replacement for an original part that is missing or has failed due to fatigue
  • Durable construction – this part is made from quality materials to ensure reliable performance and long service life
  • Trustworthy quality – backed by team of product experts in the United States and more than a century of automotive experience
See More

Yukon Gear – Spindle Nut Retainer For Dana 60 & 70, 1.830" I.D., 10 Outer TABS (Part No.33477)

Spindle Nut Retainer For Dana 60 & 70, 1.830" I.D., 10 Outer TABS

from

$10.99
Spindle nut retainer for Dana 60 & 70, 1.830″ I.D., 10 outer tabs. This replaces Spicer part number 30637.

Product Features:
  • Spindle nut retainer for Dana Spicer 60, 70, 70U and 70HD
  • 1.830″ I.D.
  • 10 outer tabs
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Most Popular Spindle Lock Nuts for 2021 Ford E-450 Super Duties

Enhance your 2021 Ford E-450 Super Duty with one of the 4 Spindle Lock Nuts we have in stock, starting at just $3.49.

Dorman – Standard Spindle Nut 3/4 In.-16 Hex Size 1-1/16 In. (Part No.615-072.1)

Standard Spindle Nut 3/4 In.-16 Hex Size 1-1/16 In.

from

$3.49
This spindle nut is designed to match the fit and function of the original part on specified vehicles. Made of quality materials, it is engineered for reliable performance.

Product Features:
  • Direct replacement – this spindle nut matches the fit and function of the factory part on specified years, makes and models
  • Ideal solution – this nut is a reliable replacement for an original part that is missing or has failed due to fatigue
  • Durable construction – this part is made from quality materials to ensure reliable performance and long service life
  • Trustworthy quality – backed by team of product experts in the United States and more than a century of automotive experience
See More

Dorman – Standard Spindle Nut 3/4 In.-16 Hex Size 1-1/16 In. (sold by each) (Part No.615-072)

Standard Spindle Nut 3/4 In.-16 Hex Size 1-1/16 In. (sold by each)

from

$4.79
This spindle nut is designed to match the fit and function of the original part on specified vehicles. Made of quality materials, it is engineered for reliable performance.

Product Features:
  • Direct replacement – this spindle nut matches the fit and function of the factory part on specified years, makes and models
  • Ideal solution – this nut is a reliable replacement for an original part that is missing or has failed due to fatigue
  • Durable construction – this part is made from quality materials to ensure reliable performance and long service life
  • Trustworthy quality – backed by team of product experts in the United States and more than a century of automotive experience
See More

Dorman – Spindle Nut 2 In.-16 Hex Size 3 In. (sold by each) (Part No.615-133)

Spindle Nut 2 In.-16 Hex Size 3 In. (sold by each)

from

$40.49
This spindle nut is designed to match the fit and function of the original part on specified vehicles. Made of quality materials, it is engineered for reliable performance.

Product Features:
  • Direct replacement – this spindle nut matches the fit and function of the factory part on specified years, makes and models
  • Ideal solution – this nut is a reliable replacement for an original part that is missing or has failed due to fatigue
  • Durable construction – this part is made from quality materials to ensure reliable performance and long service life
  • Trustworthy quality – backed by team of product experts in the United States and more than a century of automotive experience
See More

Dorman – Spindle Nut 2 In.-16 Hex Size 3 In. (Part No.615-133.1)

Spindle Nut 2 In.-16 Hex Size 3 In.

from

$39.99
This spindle nut is designed to match the fit and function of the original part on specified vehicles. Made of quality materials, it is engineered for reliable performance.

Product Features:
  • Direct replacement – this spindle nut matches the fit and function of the factory part on specified years, makes and models
  • Ideal solution – this nut is a reliable replacement for an original part that is missing or has failed due to fatigue
  • Durable construction – this part is made from quality materials to ensure reliable performance and long service life
  • Trustworthy quality – backed by team of product experts in the United States and more than a century of automotive experience
See More

Top-Rated Spindle Brands For Your 2021 Ford E-450 Super Duty

When it comes to finding the perfect Spindle for your 2021 Ford E-450 Super Duty, Advance Auto Parts has you covered with a wide selection of high-quality OEM and aftermarket options from 1 trusted brands. We carry the most popular Spindle brands including Dorman, and more, all known for their exceptional customer ratings (average brand rating of 4.2 stars) and competitive prices, as low as $3.49. Purchasing a Spindle from us here at Advance Auto Parts is a smart move for both you and your 2021 Ford E-450 Super Duty, providing peace of mind with parts that meet or exceed OEM standards.

Popular Dorman 2021 Ford E-450 Super Duty Spindles

If you’re looking for a top-quality Spindle for your 2021 Ford E-450 Super Duty, Advance Auto Parts has exactly what you need with our selection of Dorman Spindles. We have 1 Dorman Spindles in stock for this fitment, all known for their durability and precision fit. With prices starting at just $3.49, you’ll find the perfect Spindle for your needs and budget. Dorman Spindles for the 2021 Ford E-450 Super Duty come highly rated, with over 3 customer reviews and an impressive average rating of 4.2 stars. Choosing a Dorman Spindle from Advance Auto Parts is a smart move to ensure quality and value for your vehicle.
Standard Spindle Nut 3/4 In.-16 Hex Size 1-1/16 In.
from $3.49
(3)
Standard Spindle Nut 3/4 In.-16 Hex Size 1-1/16 In.
“Same as oem”

FAQs for 2021 Ford E-450 Super Duty Spindles

What are the best-selling Spindles for 2021 Ford E-450 Super Duties?

Out of 4 Spindles that fit 2021 Ford E-450 Super Duties, the following parts are the top sellers:

What’s the price range for 2021 Ford E-450 Super Duty Spindles?

The prices of Spindles for the 2021 Ford E-450 Super Duty range from $3.49 up to $40.49 for the most premium parts.

What is the average price of a Spindle for a 2021 Ford E-450 Super Duty?

The average price for Spindles for the 2021 Ford E-450 Super Duty is $22.19. Keep in mind the variety of part types within our Spindle category, where you are likely to find a wide range of prices across a variety of parts and components.

Does Advance Auto Parts sell Spindles for other Ford E-450 Super Duty model years?

Yes, we carry Spindles for 18 model years of Ford E-450 Super Duties between 2003 and 2024. The following model years are the most popular for Spindle purchases: 2019, 2018, 2017, 2016, 2015, 2014, 2013, 2012, and 2011.

What are the cheapest Spindles for my 2021 Ford E-450 Super Duty?

The cheapest 2021 Ford E-450 Super Duty Spindles we carry are:

Does Advance Auto Parts sell Spindles for any other 2021 Ford models?

Yes. We stock Spindles for 8 other popular 2021 Ford models. Some of the most popular are 2021 E-350 Super Duty Spindles, 2021 Expedition Spindles, 2021 F-150 Spindles, 2021 F-250 Super Duty Spindles, and 2021 F-350 Super Duty Spindles.

What are the top-rated Spindles that fit the 2021 Ford E-450 Super Duty?

The one 2021 Ford E-450 Super Duty Spindle we have in stock is the Standard Spindle Nut 3/4 In.-16 Hex Size 1-1/16 In.. It is rated 5 stars and costs $3.49.

What types of Spindles do you sell for my 2021 Ford E-450 Super Duty?

We currently have just 1 Spindle in stock for a 2021 Ford E-450 Super Duty, and as of 11/2/25, it is a Spindle Lock Nut.

Can I get help with 2021 Ford E-450 Super Duty Spindle orders?

Contact our customer support team by chat or phone, through the help desk page, where you can find instant answers about Ford Spindles and more.

What is your return policy for Ford E-450 Super Duty Spindles?

Advance Auto Parts keeps returns simple. For new Ford E-450 Super Duty Spindles and accessories, your online orders can be returned, in their original condition, within 45 days. For requirements, see the returns page.