2021 Ford E-350 Super Duty Ignition and Tune-Up Products

Name: Single Lead Spark Plug Wire
Brand: Motorcraft
SKU: WR-6170
Price: 39.99 USD

Below you will find various in-demand Ford Ignition and Tune-Up Products, components and accessories for your 2021 E-350 Super Duty. Advance Auto Parts has popular E-350 Super Duty parts like Ignition Switches, Ignition Boots, Ignition Coils and Boots and more. You’ll also find aftermarket and OEM Ignition and Tune-Up Products for other E-350 Super Duty model years including 2014, 2015, 2016, 2017, 2018, 2019, 2022, 2023, 2024 and more. Select a category of 2021 Ford E-350 Super Duty Ignition and Tune-Up Products below and start saving instantly.

Popular 2021 Ford E-350 Super Duty Ignition and Tune-Up Products Categories

Ignition Switch Bulbs

Ignition Starter Switches

Single Spark Plug Wires

Essential Ignition and Tune-Up Products for 2021 Ford E-350 Super Duties

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$39.99

Motorcraft Single Lead Spark Plug Wires must endure a series of punishing tests including a series of demanding test-to-failure endurance and materials durability tests to ensure their long-lasting quality and operation.

Product Features:

The only parts recommended by Ford Motor Company for Ford, Lincoln and Mercury vehicles.
Motorcraft ignition system components create and control the electrical functions of engine operation in Ford-built vehicles.
The ignition includes the Ignition Coil and modules that generate up to 46,000 volts for spark plug firing as well as the crankshaft position monitor and Power Train Control module or PCM.
Motorcraft Ignition components are manufactured to exacting Ford OE specifications and quality standards.
As with all Motorcraft aftermarket parts, any engineering innovations or product improvements developed since the vehicle’s manufacture are added to these Ignition components, ensuring the most current technology.

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$26.99

Carquest Premium knock sensors are designed to perform in harsh engine environments and meet or exceed original equipment (O.E.) specifications. Carquest Premium knock sensors are built by manufacturers that meet IATF 16949 certified framework, an internationally recognized proof of quality in the automotive industry. We utilize advanced technology to design sensors that are, in many cases, stronger than OE parts. Carquest Premium knock sensors undergo extensive validation testing to ensure long-lasting performance and reliability. Carquest Premium knock sensors are part of our Carquest Vehicle Solutions, which is a full line of engine management and electronics products that help control ignition, fuel delivery and emission systems. Carquest Vehicle Solutions are OE-quality parts designed, engineered and tested by world-class manufacturers to ensure a reliable and long-lasting repair.

Product Features:

Designed to meet or exceed OE specifications for fit, form and function
Trivalent iridescent chromate plating prevents corrosion
Silicone seals prevent moisture intrusion preventing false codes and sensor failure
Wiring harnesses utilize high-temperature insulation when applicable
Extensive design validation testing and 100% end-of-line tested
Carquest Vehicle Solutions Technical Support available from ASE certified technicians: 1-866-687-5413

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$35.99

Carquest Knock Sensors respond to a wide range of engine knock frequencies providing accurate engine condition to the ECM for optimal ignition timing. Highest quality piezoceramic element manufactured to tight tolerances for increased durability. All Carquest Knock Sensors are designed to meet or exceed OEM specifications at our ISO TS16949 manufacturing facilities.

Product Features:

Precision piezoceramic element ensures accurate response to a wide range of engine vibrations
Manufactured using the highest quality OEM materials to ensure optimal performance and rugged durability
Designed to meet or exceed all OEM specifications in fit, form & function
Extensive product testing includes salt spray, high/low temperature impact, thermal cycling, vibration, drop among other tests, to ensure all sensors meet or exceed OEM specifications.

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$66.99

The Ignition Knock (Detonation) Sensor monitors vibrations caused by engine knock or detonation to alter the ignition timing and prevent detonation. A piezoelectric crystal generates a varying voltage based upon engine vibration intensity to delay ignition timing to help prevent severe and costly engine damage. Reasons for replacement include check engine light illumination, engine hesitation, poor fuel economy or failed emissions test.

Product Features:

ADVANCED TECHNOLOGY: Manufactured to operation performance standards to meet or exceed OE fit, form, and function to ensure proper ignition timing.
INSTALLATION AND SUPPORT: Mounting threads, harness length and wire gauge match OE for easy, worry free installation.
THE DIFFERENCE: Reinforced components are used to reduce the chance of part failure and prevent corrosion and moisture penetration. Shielded harness prevents electrical interference.

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$28.99

Bosch OE quality knock sensors for optimum engine protection and fuel consumption reduction up to 9%.

Product Features:

Bosch OE quality knock sensors for optimum engine protection
Bosch OE quality knock sensors increase torque up to 5%
Bosch OE quality knock sensors enable the use of multiple quality fuels with various anti-knock properties

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$47.99

Carquest Premium Vehicle Solutions provides high-quality solutions for a wide range of applications. The Ignition Switch allows for reliable control of the vehicle’s electrical systems and engine start-up, enhancing convenience and ensuring consistent performance during operation. Engineered for maximum performance and durability, our products are built to excel in even the most demanding conditions, ensuring reliable operation and long-lasting value.

Product Features:

Durable Construction: Designed with high-quality materials to withstand harsh environmental conditions, ensuring long-lasting performance in extreme temperatures, vibrations, and moisture exposure.
Precision Engineering: Accurate sensing and switching capabilities provide reliable performance, reducing the risk of malfunctions and improving vehicle safety and efficiency.
Easy Installation & Maintenance: Designed for quick installation and minimal upkeep, reducing downtime and repair costs for both manufacturers and consumers.
Fit/Form/Function: Each vehicle electronic component is engineered to meet or surpass OEM standards, ensuring precise fit, optimal functionality, and reliable performance.

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$99.99

The only parts recommended by Ford Motor Company for Ford, Lincoln and Mercury vehicles.

Product Features:

Direct-fit, OE replacement parts – identical to factory installed parts. Robust design helps provide long operating life and excellent performance.
All OE switch functions are maintained. Factory connectors help ensure a solid, positive connection. Provided factory mounting points ensure easy installation – new gaskets and attaching hardware is included, where applicable.

from

$62.99

Durable Construction: Designed with high-quality materials to withstand harsh environmental conditions, ensuring long-lasting performance in extreme temperatures, vibrations, and moisture exposure.
Precision Engineering: Accurate sensing and switching capabilities provide reliable performance, reducing the risk of malfunctions and improving vehicle safety and efficiency.
Easy Installation & Maintenance: Designed for quick installation and minimal upkeep, reducing downtime and repair costs for both manufacturers and consumers.
Fit/Form/Function: Each vehicle electronic component is engineered to meet or surpass OEM standards, ensuring precise fit, optimal functionality, and reliable performance.

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$70.99

Durable Construction: Designed with high-quality materials to withstand harsh environmental conditions, ensuring long-lasting performance in extreme temperatures, vibrations, and moisture exposure.
Precision Engineering: Accurate sensing and switching capabilities provide reliable performance, reducing the risk of malfunctions and improving vehicle safety and efficiency.
Easy Installation & Maintenance: Designed for quick installation and minimal upkeep, reducing downtime and repair costs for both manufacturers and consumers.
Fit/Form/Function: Each vehicle electronic component is engineered to meet or surpass OEM standards, ensuring precise fit, optimal functionality, and reliable performance.

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$157.99

As the innovator and leader in stick coil technology DENSO has conducted superior testing and inspection processes to insure the highest quality ignition coil. Don’t be fooled by imitations – look for the DENSO name to be sure you’re getting the best.

Product Features:

First Time Fit
Built to DENSO Original Equipment Standards

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$153.99

Every single Delphi ignition coil is designed and endurance tested using high quality materials. This ensures fast starts, consistent engine performance and optimized fuel efficiency. We makes more than 10 million ignition coils for North America each year, and each one is engineered to OE design specifications for vehicles from Ford, Toyota, Nissan, Lexus, GM, Mazda, Chrysler, Subaru, Acura and more.

Product Features:

Delphi coils provide OE performance, durability and electromagnetic capacity level requirements
Delphi ignition coils are designed to operate as part of an integral engine management system to insert power into spark plugs and ensure fast starts; consistent engine performance and optimized fuel efficiency
Delphi uses winding process techniques to control the length of wire between adjacent windings; that’s important since more length means greater voltage differences and can create more pressure that could break down the insulation and wire coating
We back our ignition coil design with proven materials, such as high quality wires and wire coating that resists the cracks, pin holes and imperfections that most often lead to failure issues

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$128.99

Carquest Premium ignition coils meet or exceed original equipment (OE) specifications and are developed by top OE/OES manufacturers to ensure superior performance. All of our Carquest Premium ignition coils are developed by IATF 16949 certified manufacturers for consistent durability and long-lasting performance. These ignition coils use high-quality components and will utilize optimized designs on applications where the OE ignition coil had frequent failures. We require stringent testing standards to ensure proper fit and performance for each application and stand behind our Carquest Premium ignition coils with an industry-leading warranty. Carquest Premium ignition coils are part of our Carquest Vehicle Solutions, which is a full line of engine management and electronics products that help control ignition, fuel delivery and emission systems. Carquest Vehicle Solutions are OE-quality parts designed, engineered and tested by world-class manufacturers to ensure a reliable and long-lasting repair.

Product Features:

Built by IATF 16949 certified manufacturers for consistent durability
Coil drivers match OE for current limit, electrostatic discharge (ESD) protection and multi-spark
Segmented secondary bobbins to distribute high voltage and prevent shorting
100% end-of-line tested to ensure proper performance
Carquest Vehicle Solutions Technical Support available from ASE certified technicians: 1-866-687-5413

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$153.99

NGK ignition coils are manufactured to meet or exceed OE standards for the highest durability and operational performance, so they can be installed with confidence. NGK and their family of automotive products have over 80 years’ experience and are driven by extreme dedication to innovation, performance and quality. With state-of-the-art manufacturing, inventory and distribution facilities in North America and globally, NGK is dedicated to providing customers with world-class products and services. Developed and rigorously tested in our ISO 17025 accredited test lab under the most extreme conditions, NGK’s coil designs will outperform all others – far beyond operational environments a vehicle would actually experience. NGK ignition coils have vast coverage including late-model domestic and import vehicles. NGK’s OE legacy, unsurpassed quality and leading vehicles in operation coverage reinforces NGK as The Ignition Specialist.

Product Features:

OE QUALITY: Vacuum-sealed premium epoxy resin and thermoplastic coil housings provide superior dielectric strength, voltage insulation and durability
OPTIMAL PERFORMANCE: Precision coil windings and laminations maximize outputs, custom NGK ASIC chipset optimizes efficiency, prevents component damage
EASE OF INSTALLATION: NGK Ignition Coils include ignition control module, premium high temperature coil boot, and jumper harnesses where required
THE NGK DIFFERENCE: Featuring superior materials and design enhancements
EXTENSIVE TESTING: NGK ignition coils must pass extreme testing during manufacturing to ensure the highest quality and durability standards are met
PRODUCT ENGINEERING: Advanced flow and stress modeling systems preemptively identify and avoid common failure points found in OE and competitor coils

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$14.99

NGK Iridium IX spark plugs are specifically designed for the performance enthusiast. Iridium IX provides outstanding acceleration, high fuel efficiency and durability. NGK Iridium IX plugs offer extreme ignitability and exceptional anti-fouling. Tapered c

Product Features:

SINGLE IRIDIUM TIP: Fine wire 0.6 millimeter iridium tip center electrode ensures high durability and a consistently stable spark
IRIDIUM ALLOY CENTER ELECTRODE: Iridium’s density (6x that of platinum) and extremely high melting point is perfect for modern high efficiency engines
TAPERED CUT GROUND ELECTRODE: Reduced quenching design produces outstanding ignitability, improved acceleration, fuel efficiency and durability
SOLID COPPER CORE: 98% pure copper core offers superior heat dissipation, conductivity and ultra wide heat ranges
TRIVALENT METAL PLATING: Delivers superior anti-corrosion and anti-seizing properties, ensuring ease of installation and removal
RECOMMENDED USAGE: Modified or high performance applications, or as an upgrade to OE nickel alloy spark plugs

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$10.49

The Fine Wire Spark Plug is engineered for optimal ignition performance, featuring a platinum center electrode tip for exceptional durability and consistent spark delivery. Its fine wire design ensures enhanced ignition efficiency, promoting better fuel combustion and improved engine performance. The nickel ground electrode tip adds to its robust construction, ensuring reliable operation under demanding conditions. Designed with a tapered seat type, this spark plug provides a secure fit and effective sealing, reducing the risk of gas leakage. Built to last, it offers excellent resistance to wear and high temperatures, making it a dependable choice for maintaining your vehicle’s performance. Whether you’re looking to replace a worn-out spark plug or upgrade for better efficiency, this part delivers outstanding value and reliability.

Product Features:

Fine wire design enhances ignition efficiency, promoting better fuel combustion and improved engine performance.
Platinum center electrode tip ensures exceptional durability and consistent spark delivery over time.
Nickel ground electrode tip provides robust construction for reliable operation under demanding conditions.
Tapered seat type ensures a secure fit and effective sealing, reducing the risk of gas leakage.
Excellent resistance to wear and high temperatures ensures long-lasting performance and reliability.

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$3.49

The U-Groove Spark Plug with its patented U-groove ground electrode design ensures superior ignitability, allowing your engine to fire leaner mixtures for enhanced efficiency and performance. Built with a durable nickel center electrode tip, it delivers long-lasting performance while improving fuel consumption and emission gas purification. Precision machine-rolled threads minimize the risk of seizing or cross-threading, making it ideal for use in delicate aluminum heads. Designed to last twice as long as most conventional plugs, this spark plug is 100% pre-fired to guarantee reliable operation from the start. Its tapered seat type ensures a secure fit, and with a wide range of part numbers available, its compatible with thousands of applications, including classic and collector cars. Whether you’re maintaining a daily driver or restoring a vintage vehicle, this spark plug offers OE performance and exceptional value.

Product Features:

Patented U-groove ground electrode design fires leaner mixtures than conventional plugs
Precision machine-rolled threads reduce seizing and cross-threading in delicate aluminum heads
Wide range of part numbers for thousands of applications, including classic and collector cars
Lasts twice as long as most conventional plugs
100 percent pre-fired to assure reliable operation
U-Groove Conventional
Durable Nickel Center Electrode Tip: Provides long-lasting performance and improved efficiency in emission gas purification and fuel consumption.

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$14.99

NGK Ruthenium HX High Ignitability spark plugs are the best in class plug for todays modern vehicles. Patented Ruthenium technology offers the most advance tip technology and delivers the highest performance and life expectancy. Created from advanced OE technology as a high ignitability plug, Ruthenium HX spark plugs come with patented, specialized OEM DFE and PSPE tip designs. NGK Ruthenium HX High Ignitability spark plugs provide a more complete fuel burn resulting in a quicker throttle response, smoother idle and better cold starts. Ruthenium center electrode provides industry leading durability.

Product Features:

HIGH IGNITABILITY PROJECTED SQUARE PLATINUM ELECTRODE DESIGN: Combines 0.6 millimeter ruthenium center with a unique cut-back PSPE ground electrode
RUTHENIUM ALLOY CENTER ELECTRODE: NGK’s patented ruthenium technology produces maximum performance, ignitability & durability at high temperatures
PSPE DESIGN: Projected square platinum electrode shape of the ground electrode provides the best ignitability and service life for high heat engines
SOLID COPPER CORE: 98% pure copper core offers superior heat dissipation, conductivity and ultra wide heat ranges
TRIVALENT METAL PLATING: Delivers superior anti-corrosion and anti-seizing properties, ensuring ease of installation and removal
RECOMMENDED USAGE: Modern vehicles using OE PSPE type spark plugs or for those seeking an aftermarket plug with the latest OE technology
Enhanced Fuel Burn: Provides a more complete fuel burn, resulting in quicker throttle response, smoother idle, and better cold starts.
Industry-Leading Durability: Ruthenium center electrode ensures exceptional durability and longevity.

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$166.99

ACCEL HP Spark Plugs are made with a Copper core which is a better conductor than Platinum and Iridium. They deliver a stronger spark especially in high performance applications where high combustion pressures are present. Copper is much better at dissipating heat than other materials which lessens the chance of a misfire. ACCEL HP Spark Plugs are capable allowing you to open the gap exposing a larger flame kernel or close it if needed for high boost applications. All ACCEL HP Spark Plugs have machine rolled threads allowing for a more precise thread engagement and torque retention.

Product Features:

The Copper core is a better conductor than Iridium or Platinum plugs
Copper dissipates heat much better than other materials
C – Cut Design un-shrouds the spark kernel for a better burn
Unlike Iridium or Platinum plugs, the ACCEL HP plugs are capable
Machine rolled threads for precise thread engagement
One step colder than stock
Whether using on the street or on the strip, ACCEL HP Copper Core spark plugs deliver.

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$23.99

Upgrade your vehicle with ZEVO® LED miniature bulbs for added style, performance, and the many benefits of LEDs. Instantly enhance the interior and exterior lighting applications of your vehicle with a modern bright white light for head-turning style and increased visibility by other motorists. Easy-to-install with a robust design and high-quality components, ZEVO replacement bulbs are backed by a limited warranty to provide exceptional performance through the life of the vehicle. Also available in an array of colors to update your car or truck.

Product Features:

HIGH EFFICIENY: Delivers greater clarity with less power consumption and longer bulb life when compared to standard incandescent bulbs
RELIABLE: Thermal management to maximize life, matched with robust design that withstands temperature and shock for optimal performance
NON-POLARITY DESIGN: Plug & play easy installation; SYLVANIA ZEVO LED bulbs light on two sides and can be installed either direction
INSTANT ON: Provide full brightness instantly, giving drivers around you more time to react, compared to the slower light-up with Incandescent bulbs
BRIGHT WHITE LIGHT: Ideal for use in Daytime running lights (DRL), back up/reverse, map, dome, trunk, cargo and license plate light bulb replacement
HYPERFLASH: For some vehicles, installing a load equalizer may be required to eliminate hyper flash or dashboard error messages
EASY DIY INSTALLATION: A direct replacement for the factory bulbs in your vehicle, no modification required
SMART MAINTENANCE: Always replace bulbs in pairs to ensure equal brightness and color.
SAFETY: High-quality SYLVANIA bulbs are designed to perform to all relevant safety standards set for the lighting application.
TRUSTED BRAND: SYLVANIA is a trusted OEM automotive lighting manufacturer, with over 100 years of superior optical engineering experience

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$21.79

Motorcraft Ignition Boots are engineered to provide original equipment performance and reliability. All Motorcraft parts undergo rigorous lab and real-world tests in order to meet strict Ford engineering standards. Terminal ends are designed to help ensure they do not separate from the cable under normal service conditions. High dialectic insulation helps maintain and control voltage delivery while reducing radio frequency interference. The only parts recommended by Ford Motor Company for Ford, Lincoln and Mercury vehicles

Product Features:

Backed by Motorcraft’s Service Parts Warranty
Designed for long life – key life durability testing (equivalent to 10 years/150,000 miles) is conducted in addition to on-vehicle durability testing.
Boots must pass submerged and pressurized leak tests, as well as low temperature cycle tests.
Durability tests subject boots to 225,000 performance cycles including temperature extremes from minus 40 degrees F to 275 degrees F.
Motorcraft ignition components help prevent false check engine lights.

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$56.99

Pc Cop Boots 97-11 Ford 8-Cyl

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$38.99

Carquest Premium spark plug boot sets are engineered to restore ignition boot reliability and performance. They are designed to meet or exceed original equipment (O.E.) specifications for fit, form and function. Our spark plug boots offer excellent heat resistance as well as maximum protection against spark loss. Carquest Premium spark plug boot sets are built with a durable silicone compound for resistance to high heat and abrasion, resulting in a longer-lasting ignition repair. Carquest Premium spark plug boot sets include all boots needed for each vehicle application for a complete tune-up repair.

Product Features:

Product Features:

Complete set of boots for a complete tune-up and better value
OE design provides an exact fit for your application
Provides excellent heat resistance as well as maximum protection against spark loss
Durable silicone compound for resistance to high heat or abrasion
Spring included with the coil boot
Design for direct compatibility

Upgrade your 2021 Ford E-350 Super Duty with Top-Quality Ignition and Tune-Up Products

When it comes to maintaining or upgrading your 2021 Ford E-350 Super Duty, nothing is more important than using high-quality OEM or aftermarket parts that you can trust. Whether you’re repairing damage to your Ford or enhancing its overall performance, Ignition and Tune-Up Products are key to keeping your E-350 Super Duty functioning at its best. At Advance Auto Parts, we offer a wide selection of 14 Ignition and Tune-Up Products for the 2021 Ford E-350 Super Duty, designed to meet your needs without breaking the bank. From Ignition Switch replacements to Ignition Boots upgrades, we’ve got you covered with parts that fit your vehicle perfectly and ensure long-lasting performance.

Affordable Prices and Wide Selection

Shopping for Ignition and Tune-Up Products for any vehicle can be a hassle, especially if you’re on a budget. But with Advance Auto Parts, you can find high-quality Ignition and Tune-Up Products for your 2021 Ford E-350 Super Duty at great prices. Our Ignition and Tune-Up Products inventory for this model ranges from just $7.99 to $201.99, with an average price of $45.08. Our 14 Ignition and Tune-Up Products in stock come from 6 trusted brands, so you’re sure to find the right part for your 2021 Ford E-350 Super Duty without overspending.

Top Brands and High Customer Satisfaction

Advance Auto Parts takes pride in offering only the best brands in the automotive industry. For your 2021 Ford E-350 Super Duty, we stock popular OEM and aftermarket Ignition and Tune-Up Products from top names like NGK, Sylvania, E3, and more. NGK Ignition and Tune-Up Products start at just $14.99 and boast an impressive 4.8 stars average rating from customers. Sylvania and E3 also bring quality to the table, with Ignition and Tune-Up Products available starting at $8.49, and at an average 4.3 stars rating. With 358 customer reviews and counting, our 2021 Ford E-350 Super Duty Ignition and Tune-Up Products have a strong track record of reliability, ensuring you can trust your purchase.

Explore Related Parts and More

While you’re here, don’t forget to check out other essential categories that go hand in hand with Ignition and Tune-Up Product upgrades. Explore related part types like Batteries and Chargers, Oil and Lubricants and more to make sure your 2021 Ford E-350 Super Duty is always ready to roll. We’re committed to providing you with everything you need to keep your E-350 Super Duty in top shape, all in one place. Start shopping confidently below for your 2021 Ford E-350 Super Duty!

Best-Selling Ignition Switches for 2021 Ford E-350 Super Duties

Enhance the driving experience in your Ford with 4 quality Ignition Switch components, starting at $23.99.

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$23.99

HIGH EFFICIENY: Delivers greater clarity with less power consumption and longer bulb life when compared to standard incandescent bulbs
RELIABLE: Thermal management to maximize life, matched with robust design that withstands temperature and shock for optimal performance
NON-POLARITY DESIGN: Plug & play easy installation; SYLVANIA ZEVO LED bulbs light on two sides and can be installed either direction
INSTANT ON: Provide full brightness instantly, giving drivers around you more time to react, compared to the slower light-up with Incandescent bulbs
BRIGHT WHITE LIGHT: Ideal for use in Daytime running lights (DRL), back up/reverse, map, dome, trunk, cargo and license plate light bulb replacement
HYPERFLASH: For some vehicles, installing a load equalizer may be required to eliminate hyper flash or dashboard error messages
EASY DIY INSTALLATION: A direct replacement for the factory bulbs in your vehicle, no modification required
SMART MAINTENANCE: Always replace bulbs in pairs to ensure equal brightness and color.
SAFETY: High-quality SYLVANIA bulbs are designed to perform to all relevant safety standards set for the lighting application.
TRUSTED BRAND: SYLVANIA is a trusted OEM automotive lighting manufacturer, with over 100 years of superior optical engineering experience

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$83.99

The only parts recommended by Ford Motor Company for Ford, Lincoln and Mercury vehicles.

Product Features:

Direct-fit, OE replacement parts – identical to factory installed parts. Robust design helps provide long operating life and excellent performance.
All OE switch functions are maintained. Factory connectors help ensure a solid, positive connection. Provided factory mounting points ensure easy installation – new gaskets and attaching hardware is included, where applicable.

from

$99.99

The only parts recommended by Ford Motor Company for Ford, Lincoln and Mercury vehicles.

Product Features:

Direct-fit, OE replacement parts – identical to factory installed parts. Robust design helps provide long operating life and excellent performance.
All OE switch functions are maintained. Factory connectors help ensure a solid, positive connection. Provided factory mounting points ensure easy installation – new gaskets and attaching hardware is included, where applicable.

from

$62.99

Durable Construction: Designed with high-quality materials to withstand harsh environmental conditions, ensuring long-lasting performance in extreme temperatures, vibrations, and moisture exposure.
Precision Engineering: Accurate sensing and switching capabilities provide reliable performance, reducing the risk of malfunctions and improving vehicle safety and efficiency.
Easy Installation & Maintenance: Designed for quick installation and minimal upkeep, reducing downtime and repair costs for both manufacturers and consumers.
Fit/Form/Function: Each vehicle electronic component is engineered to meet or surpass OEM standards, ensuring precise fit, optimal functionality, and reliable performance.

Top Picks for 2021 Ford E-350 Super Duty Ignition Coils and Boots

Upgrade Ford E-350 Super Duties with top-quality Ignition Coils and Boots parts, including 1 OEM and aftermarket selections for your 2021 model.

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$201.99

Built by IATF 16949 certified manufacturers for consistent durability
Coil drivers match OE for current limit, electrostatic discharge (ESD) protection and multi-spark
Segmented secondary bobbins to distribute high voltage and prevent shorting
100% end-of-line tested to ensure proper performance
Carquest Vehicle Solutions Technical Support available from ASE certified technicians: 1-866-687-5413

In-Demand Ignition Sensors for 2021 Ford E-350 Super Duties

Select from 1 premium Ignition Sensors parts for your 2021 Ford E-350 Super Duty.

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$26.99

Designed to meet or exceed OE specifications for fit, form and function
Trivalent iridescent chromate plating prevents corrosion
Silicone seals prevent moisture intrusion preventing false codes and sensor failure
Wiring harnesses utilize high-temperature insulation when applicable
Extensive design validation testing and 100% end-of-line tested
Carquest Vehicle Solutions Technical Support available from ASE certified technicians: 1-866-687-5413

Most Sold 2021 Ford E-350 Super Duty Spark Plugs

Explore our best-selling Ford parts for the 2021 E-350 Super Duty among 7 OEM and aftermarket options starting from $7.99.

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$14.99

HIGH IGNITABILITY PROJECTED SQUARE PLATINUM ELECTRODE DESIGN: Combines 0.6 millimeter ruthenium center with a unique cut-back PSPE ground electrode
RUTHENIUM ALLOY CENTER ELECTRODE: NGK’s patented ruthenium technology produces maximum performance, ignitability & durability at high temperatures
PSPE DESIGN: Projected square platinum electrode shape of the ground electrode provides the best ignitability and service life for high heat engines
SOLID COPPER CORE: 98% pure copper core offers superior heat dissipation, conductivity and ultra wide heat ranges
TRIVALENT METAL PLATING: Delivers superior anti-corrosion and anti-seizing properties, ensuring ease of installation and removal
RECOMMENDED USAGE: Modern vehicles using OE PSPE type spark plugs or for those seeking an aftermarket plug with the latest OE technology
Enhanced Fuel Burn: Provides a more complete fuel burn, resulting in quicker throttle response, smoother idle, and better cold starts.
Industry-Leading Durability: Ruthenium center electrode ensures exceptional durability and longevity.

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$8.49

The Spark Plugs are the product of years of fundamental research in the combustion field. The unique patented electrode configuration of these new The spark plugs increases the amount of combustion pressure created during each power stroke of an engine, which results in a marked increase in power output, fuel economy, and reduced emissions in all gasoline engines. E3.74 is a 14mm, 1.000 reach plug with a taper seat. It fits a wide variety of late model applications, especially Ford applications. The automotive plugs have three legs securing the Diamond FIRE electrode to the shell. This allows for excellent heat transfer, and helps to create more turbulence in the cylinder. The patented Diamond FIRE side wire is proven to increase power, reduce fuel consumption and improve hydrocarbon emissions in long-term use.

Product Features:

E3’s Diamond Fire edge to edge ground electrode provides maximum performance with increased efficiency and a faster more complete burn
Smoother Acceleration & Idle – The faster flame initiated by the spark plug results in a more complete burn of the ingested fuel charge. More pressure is created against the piston more fuel is put to work
Energy – Power output improved up to 6% on average in the typical operating ranges. Results will vary.
Efficiency – The “diamond shaped” side wire electrode projects the combustion spark in a way that more quickly ignites the air/fuel mixture, thereby creating a significantly faster and larger flame kernel. The result is that more fuel is put to work durin
E3’s patented Diamond Fire Technology provides a cleaner burning combustion, which translates into fuel savings and reduced engine carbon deposits
The Spark Plugs are pre-gapped at the factory and cannot be adjusted.
Enhanced Heat Transfer: Three legs securing the Diamond FIRE electrode to the shell ensure excellent heat transfer and create more turbulence in the cylinder.
Wide Compatibility: The E3.74 spark plug is a 14mm, 1.000 reach plug with a taper seat, fitting a wide variety of late model applications, especially Ford vehicles.
Eco-Friendly Performance: Proven to reduce fuel consumption and improve hydrocarbon emissions, contributing to a cleaner environment.
Long-Term Efficiency: The Diamond FIRE side wire is designed for long-term use, maintaining increased power and reduced fuel consumption over time.

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$18.99

NGK Laser Platinum spark plugs provide high ignitability and longer service life compared to conventional nickel spark plugs. Laser Platinum plugs are tested to the highest standards to ensure quality and durability. Engineered specifically for OE applications. Laser platinum plugs provide stable idling, superior anti-fouling, improved fuel efficiency and lower emissions. High-grade pure alumina ceramic and 98% pure copper core prevents spark plug from overheating and provides reliable starts. Most Laser Platinum spark plugs feature a platinum pad on the ground electrode for even wear in distributorless ignition systems.

Product Features:

ACTUAL OE or EQUIVALENT DESIGN: OEM quality construction fine wire platinum alloy center electrode provides consistent performance
PLATINUM ALLOY CENTER ELECTRODE: Longer wearing and higher temperature resistance compared to traditional nickel spark plugs
PLATINUM TIP GROUND ELECTRODE: Unless OE specified, platinum protection at the ground electrode provides excellent ignitability and service life
SOLID COPPER CORE: 98% pure copper core offers superior heat dissipation, conductivity and ultra wide heat ranges
TRIVALENT METAL PLATING: Delivers superior anti-corrosion and anti-seizing properties, ensuring ease of installation and removal
RECOMMENDED USAGE: Best for vehicles with OE fine wire platinum alloy plugs

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$39.99

The only parts recommended by Ford Motor Company for Ford, Lincoln and Mercury vehicles.
Motorcraft ignition system components create and control the electrical functions of engine operation in Ford-built vehicles.
The ignition includes the Ignition Coil and modules that generate up to 46,000 volts for spark plug firing as well as the crankshaft position monitor and Power Train Control module or PCM.
Motorcraft Ignition components are manufactured to exacting Ford OE specifications and quality standards.
As with all Motorcraft aftermarket parts, any engineering innovations or product improvements developed since the vehicle’s manufacture are added to these Ignition components, ensuring the most current technology.

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$10.99

The Autolite Iridium Ultra Fine wire Spark Plug is a premium OE replacement designed to deliver exceptional performance and reliability. Featuring a laser-welded proprietary iridium alloy finewire center electrode, it ensures optimal fuel efficiency, improved acceleration, and precise ignitability. The nickel-plated shell offers superior corrosion resistance, while the high-alumina ceramic insulator enhances strength and durability under extreme conditions. With advanced platinum sidewire technology, this spark plug provides long-lasting performance and consistent ignition. Engineered for excellence, its the perfect choice for drivers seeking enhanced engine efficiency and dependable operation.

Product Features:

Autolite Iridium Ultra is an engineered OE replacement iridium spark plug.
A laser-welded proprietary iridium alloy finewire center electrode provides optimal fuel efficiency, acceleration and focused ignitability.
Nickel-plated shell to resist corrosion.
High-alumina ceramic insulator for increased strength.
Laser welded Iridium finewire center electrode.
Proprietary platinum sidewire technology.

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$7.99

Autolite has over 100 years of engineering experience and has sold over 11 billion plugs. Designed and engineered in the USA, the Autolite Iridium XP spark plugs feature an iridium-enhanced 0.6mm finewire design and patented platinum sidewire technology to provide better overall durability and a more focused ignition for enhanced ignitability and performance. Features double Iridium-enhanced alloy technology center electrode for improved durability and wear resistance.

Product Features:

0.6 mm finewire design improves ignitability
Patented V-trimmed platinum sidewire technology resists wear
OE equivalent design is engineered for every engine
Designed for better overall durability with virtually no gap erosion
Double Iridium-enhanced alloy technology center electrode ensures superior wear resistance for long-lasting performance.

from

$7.99

The Motorcraft High-Performance Spark Plug is expertly crafted to deliver superior ignition performance and optimize fuel efficiency, ensuring reliable starts and smoother engine operation. Featuring a standard center electrode design with an iridium tip and a nickel ground electrode tip, this spark plug is built for exceptional durability and long-lasting performance. Its tapered seat type ensures a secure fit, making it a dependable choice for maintaining your vehicle’s peak performance. Designed to enhance engine responsiveness and improve overall fuel economy, this spark plug is an excellent upgrade for drivers seeking consistent and efficient performance. With precision engineering and high-quality materials, the Motorcraft High-Performance Spark Plug offers unmatched value, helping you save on fuel costs while keeping your engine running at its best.

Product Features:

Enhances Fuel Efficiency: The Motorcraft High-Performance Spark Plug is specifically designed to optimize fuel efficiency, helping you save on fuel costs.
Superior Ignition Performance: Engineered for superior ignition performance, this spark plug ensures reliable starts every time.
Exceptional Durability: Crafted with precision, the Motorcraft High-Performance Spark Plug offers exceptional durability, providing long-lasting performance.
Consistent Performance: This spark plug delivers consistent performance, making it an ideal choice for maintaining your vehicle’s peak performance.
Improved Engine Responsiveness: Upgrade to Motorcraft and experience a noticeable difference in your engine’s responsiveness and overall fuel economy.
Enhances Fuel Efficiency: The Motorcraft High-Performance Spark Plug is specifically designed to optimize fuel efficiency, helping you save on fuel costs.
Superior Ignition Performance: Engineered for superior ignition performance, this spark plug ensures reliable starts every time.
Exceptional Durability: Crafted with precision, the Motorcraft High-Performance Spark Plug offers exceptional durability, providing long-lasting performance.
Consistent Performance: This spark plug delivers consistent performance, making it an ideal choice for maintaining your vehicle’s peak performance.
Improved Engine Responsiveness: Upgrade to Motorcraft and experience a noticeable difference in your engine’s responsiveness and overall fuel economy.

Top-Rated Ignition and Tune-Up Products Brands For Your 2021 Ford E-350 Super Duty

Shop for the best-rated brands offering Ignition and Tune-Up Products and other products for your 2021 Ford E-350 Super Duties. Below you’ll find some of our best rated Ignition and Tune-Up Products from NGK, Sylvania, and E3, and more. Ignition and Tune-Up Products from these brands that fit a 2021 E-350 Super Duty start at just $8.49 and are rated as high as 4.8 stars. OEM and aftermarket Ignition and Tune-Up Products don’t get more top quality, durable, and affordable than from the brands below.

Popular NGK 2021 Ford E-350 Super Duty Ignition and Tune-Up Products

When it comes to maintaining or upgrading your 2021 Ford E-350 Super Duty, using quality Ignition and Tune-Up Products is essential to ensure durability and a perfect fit. NGK ticks all of those boxes. We offer a wide selection of NGK Ignition and Tune-Up Products, specifically designed for the 2021 Ford E-350 Super Duty. With over 1 NGK brand Ignition and Tune-Up Products in stock, you’re sure to find what you need. The prices for these top-notch parts start as low as $14.99. Plus, with over 1 customer reviews and an average rating of 4.8 stars, you can trust that our NGK Ignition and Tune-Up Products will get the job done right. Choose Advance Auto Parts for reliability, quality, and expert-approved parts that keep your vehicle running strong.

from $14.99

(1)

Ruthenium HX Spark Plug (LTR7BHX): High Ignitability & Durability

“I got these for my 2019 Mustang Ecoboost and these were way better spark plugs then anything i have tried definitely a performance oriented, spark plu”

Popular Sylvania 2021 Ford E-350 Super Duty Ignition and Tune-Up Products

Sylvania auto parts is one of the highest quality Ignition and Tune-Up Product brands in the market. Any 2021 Ford E-350 Super Duty owner should feel confident when installing genuine Sylvania parts in their vehicle. To ensure the best fit and performance for your 2021 E-350 Super Duty, Advance Auto Parts carries a full inventory of 1 Sylvania Ignition and Tune-Up Products. Plus you will be keeping your Ford in peak condition while saving money because prices on these Sylvania Ignition and Tune-Up Products range up to $23.99, plus, with more than 1 customer reviews and an impressive 4.3 stars average rating, you can be confident the Fram Ignition and Tune-Up Products below will deliver on both quality and value.

from $23.99

(1)

194 ZEVO: White LED Mini Bulb, Super Bright, 2 Pack

“Every bit as bright as I had hoped.”

FAQs for 2021 Ford E-350 Super Duty Ignition and Tune-Up Products

Which Ignition and Tune-Up Products are best-sellers for 2021 Ford E-350 Super Duties?

Out of 14 Ignition and Tune-Up Products that fit 2021 Ford E-350 Super Duties, the following parts are the top sellers:

194 ZEVO: White LED Mini Bulb, Super Bright, 2 Pack (11920742) – $23.99
Original Equipment Spark Plug Boot: No core (outer material Rubber) Core, Qty of 1 (11333712) – $21.79
Laser Platinum Spark Plug (LTR7CP13): Fine Wire Tip for High Ignitability (12101952) – $18.99

What’s the price range for 2021 Ford E-350 Super Duty Ignition and Tune-Up Products?

Ignition and Tune-Up Product prices for the 2021 Ford E-350 Super Duty start at $7.99 and go up to $201.99 for the most premium parts.

What’s the average price of a Ignition and Tune-Up Product for a 2021 Ford E-350 Super Duty?

The average price for Ignition and Tune-Up Products for the 2021 Ford E-350 Super Duty is $45.08. Keep in mind the variety of part types within our Ignition and Tune-Up Product category so you are likely to find a wide range of prices across a variety of parts and components.

Does Advance Auto Parts sell Ignition and Tune-Up Products for other Ford E-350 Super Duty model years?

Yes, we currently carry Ignition and Tune-Up Products for 24 model years of Ford E-350 Super Duties between 2000 and 2026. Ignition and Tune-Up Products are bought most frequently for the following model years: 2023, 2022, 2024, 2019, 2018, 2017, 2016, 2015, and 2014.

What are the cheapest Ignition and Tune-Up Products for my 2021 Ford E-350 Super Duty?

The cheapest 2021 Ford E-350 Super Duty Ignition and Tune-Up Products we carry in stock are:

Iridium XP Fine wire Spark Plug: Improved Durability, More Focused Ignition (50031864) – $7.99
High-Performance Spark Plug: Enhances Fuel Efficiency (50011448) – $7.99
DiamondFIRE Automotive Spark Plug: More Power, Saves Gas (11333297) – $8.49
Iridium Ultra Fine wire Spark Plug: Optimal Fuel Efficiency & Ignitability (50046207) – $10.99
Ruthenium HX Spark Plug (LTR7BHX): High Ignitability & Durability (12069657) – $14.99

What are the top-rated Ignition and Tune-Up Products that fit the 2021 Ford E-350 Super Duty?

Out of 358 reviews by customers, our 2021 Ford E-350 Super Duty Ignition and Tune-Up Products have an average customer rating of . These are some of the highest-rated Ignition and Tune-Up Product types for the 2021 Ford E-350 Super Duty and their top-rated products:

Spark Plugs
- Ruthenium HX Spark Plug (LTR7BHX): High Ignitability & Durability (12069657) – $14.99
- DiamondFIRE Automotive Spark Plug: More Power, Saves Gas (11333297) – $8.49
Ignition Switches
- Ruthenium HX Spark Plug (LTR7BHX): High Ignitability & Durability (12069657) – $14.99
- DiamondFIRE Automotive Spark Plug: More Power, Saves Gas (11333297) – $8.49

What types of Ignition and Tune-Up Products do you sell for my 2021 Ford E-350 Super Duty?

As of 11/2/25, these are some of the most in-demand types of Ignition and Tune-Up Products for a 2021 Ford E-350 Super Duty:

Can I get help with 2021 Ford E-350 Super Duty Ignition and Tune-Up Product orders?

Contact our customer support team, by chat or phone, through the help desk page, where you can find instant answers about Ford Ignition and Tune-Up Products and more.

What is your return policy for Ford E-350 Super Duty Ignition and Tune-Up Products?

Advance Auto Parts keeps returns simple. For new Ford E-350 Super Duty Ignition and Tune-Up Products and accessories, your online orders can be returned, in their original condition, within 45 days. For requirements, see the returns page.

2021 Ford E-350 Super Duty Ignition and Tune-Up Products

Motorcraft – Single Lead Spark Plug Wire (Part No.WR-6170)

Carquest Premium – Ignition Knock (Detonation) Sensor (Part No.SBA3805)

Carquest Premium – Ignition Knock (Detonation) Sensor (Part No.SBC3679)

NTK – Ignition Knock (Detonation) Sensor (Part No.ID0141)

Bosch – Knock Sensor (Part No.0261231316)

Carquest Premium – Ignition Switch (Part No.CSC2484)

Motorcraft – Original Equipment (O.E.) Switch Assembly – Ignition (Part No.SW-6573)

Carquest Premium – Ignition Switch (Part No.CSC3797)

Carquest Premium – Ignition Switch (Part No.CSC1044)

DENSO – Direct Ignition Coil – Original Equipment Quality (Part No.673-6301)

Delphi – Ignition Coil (Part No.GN10619)

Carquest Premium – Ignition Coil (Part No.EBE1962)

NGK – Premium COP Waste Spark Type Ignition Coil: Meets or Exceeds OE Specifications (Part No.48761)

NGK – Iridium IX Spark Plug (TR55IX): Outstanding Acceleration & Durability (Part No.7164)

Motorcraft – Spark Plug: Fine Wire Design for Enhanced Ignition Efficiency (Part No.SP-521-X)

DENSO – U-Groove Spark Plug: OE Performance, T16EPR-U15 (Part No.5023)

NGK – Ruthenium HX Spark Plug (LTR7BHX): High Ignitability & Durability (Part No.95605)

Accel – Spark Plug: Ford Late V8 3-V, 1 Range Colder, 8 Pack (Part No.8161C1)

Sylvania – 194 ZEVO: White LED Mini Bulb, Super Bright, 2 Pack (Part No.194LED.BP2)

Motorcraft – Original Equipment Spark Plug Boot: No core (outer material Rubber) Core, Qty of 1 (Part No.WR-6128)

Accel – Pc Cop Boots 97-11 Ford 8-Cyl (Part No.128041)

Carquest Premium – Spark Plug Boot Set: 8 Boots, Meets or Exceeds OE Specifications (Part No.38-001FMP)

Sylvania – 194 ZEVO: White LED Mini Bulb, Super Bright, 2 Pack (Part No.194LED.BP2)

Motorcraft – Original Equipment (O.E.) Switch Assembly – Ignition (Part No.SW-6958)

Motorcraft – Original Equipment (O.E.) Switch Assembly – Ignition (Part No.SW-6573)

Carquest Premium – Ignition Switch (Part No.CSC3797)

Motorcraft – Original Equipment Spark Plug Boot: No core (outer material Rubber) Core, Qty of 1 (Part No.WR-6128)

Carquest Premium – Ignition Coil (Part No.EBA2001)

Carquest Premium – Ignition Knock (Detonation) Sensor (Part No.SBA3805)

NGK – Ruthenium HX Spark Plug (LTR7BHX): High Ignitability & Durability (Part No.95605)

E3 – DiamondFIRE Automotive Spark Plug: More Power, Saves Gas (Part No.E3.74)

NGK – Laser Platinum Spark Plug (LTR7CP13): Fine Wire Tip for High Ignitability (Part No.94862)

Motorcraft – Single Lead Spark Plug Wire (Part No.WR-6170)

Autolite Iridium – Iridium Ultra Fine wire Spark Plug: Optimal Fuel Efficiency & Ignitability (Part No.AI5862)

Autolite Iridium – Iridium XP Fine wire Spark Plug: Improved Durability, More Focused Ignition (Part No.XP5862)

Motorcraft – High-Performance Spark Plug: Enhances Fuel Efficiency (Part No.SP-589)