2021 Ford E-350 Super Duty Drivetrains

Name: Bearings
Brand: National
SKU: 15101
Price: 17.49 USD
Rating: 4.5 (17 reviews)

Below you will find various in-demand Ford Drivetrains, components and accessories for your 2021 E-350 Super Duty. Advance Auto Parts has popular E-350 Super Duty parts like Transfer Cases, Universal Joints, Drive Shafts and Axles and more. You’ll also find aftermarket and OEM Drivetrains for other E-350 Super Duty model years including 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2022 and more. Select a category of 2021 Ford E-350 Super Duty Drivetrains below and start saving instantly.

Popular 2021 Ford E-350 Super Duty Drivetrains Categories

Differential Oil

Axle Shaft Universal Joints

Drive Shaft Support Bolts

U-Joints

Center Support Bearings

Differential Bearings

Drive Shaft Bearings

Differential Bearing Kits

Input Shaft Bearings

Front Differential Pinion Bearings

Axle Flange Gaskets

Spindle Lock Nuts

Transfer Case Differential Bearings

Essential Drivetrains for 2021 Ford E-350 Super Duties

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$17.49

National Oil Seals & Bearings offer a full line of premium oil seals and bearings.

Product Features:

Premium bearing design matches OEM specifications
Precision manufactured using premium-grade steel for outstanding durability and performance
Crowned raceways and rollers to ensure even load distribution for maximum life
Industry leading coverage
Professional technicians know they can depend on National

from

$45.99

You expect a lot from your vehicle, and Spicer Life Series (SPL) universal joints deliver. SPL universal joints consistently outperform competitors, so you can hit the road or trail with confidence. Check out the difference that SPL universal joints can make in your vehicle, and make sure you are getting the longer life, increased bearing capacity and lower maintenance costs that Spicer Life Series (SPL) can provide.

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$44.99

When you see the Spicer name, you know you are buying the highest quality product available. Spicer universal joints are no exception. Dana manufactures a full line of Spicer universal joints that are engineered to ensure longer life for vehicles in a wide variety of applications, from light vehicle to commercial and off-highway.

Product Features:

OE engineering and field tested experience is why the Spicer brand is the most trusted in the industry.
Forged with high-quality steel, these u-joints are heat treated and case-hardened with precision to specific levels, ensuring optimal strength and durability.
The process of precision grinding the seal and bearing surfaces helps to improve the life of the seal and bearing.
Zerk allows for lubricating at regular intervals to help extend the life of the part.

from

$46.99

Product Features:

COMPREHENSIVE COVERAGE – Available for foreign and domestic nameplates
GREASABLE DESIGN – Greasable u-joints allow for new grease to flush out contaminants and moisture
KEEPS DIRT OUT – Nitrile rubber grease seals use a compressed double lip design for effective protection against contaminants
RIGOROUS TESTING – Comprehensive testing throughout design and development processes by MOOG engineers for quality you can count on
STRONG AND DURABLE – Bearing cups are cold-forged, case-hardened and precision ground while steel cross is forged and carburized heat treated for strength and durability
Cross forging shape and flash provide easier installation and high strength

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$61.99

Yukon 1410 U/Joint with zerk fitting. 4.188″ snap ring span, 1.118″ cap diameter. Outside snap ring.

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$27.99

Ensure a leak-free repair when servicing axle bearings or parking brake shoes. This axle shaft flange seal is a direct replacement for the original gasket and should be replaced every time work is performed at the axle flange.

Product Features:

Product Features:

Ideal replacement – this axle shaft flange seal directly replaces the original gasket without having to visit the dealer
Required for routine service – this gasket should be replaced every time work is performed at the axle flange
Durable construction – this axle shaft flange gasket is made of tough, durable materials for leak-free performance
Quality tested – this flange gasket has been designed and tested for a guaranteed fit

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$22.49

This drive shaft bolt is designed to match the fit and function of the original part on specified vehicles. Made of quality materials, it is engineered for reliable performance.

Product Features:

Direct replacement – this engine mount bolt matches the fit and function of the factory part on specified years, makes and models
Ideal solution – this drive shaft bolt is a reliable replacement for an original part that is missing or has failed due to fatigue
Durable construction – this part is made from quality materials to ensure reliable performance and long service life
Trustworthy quality – backed by team of product experts in the United States and more than a century of automotive experience

from

$148.99

Redline Synthetic “Shock Proof” Oil with positraction Additive. 4 Quarts.

Product Features:

Includes four quarts of Redline Shockproof oil and one 4oz bottle of Yukon positraction additive

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$11.99

Valvoline DEX/MERC ATF is a high-quality transmission fluid formulated to meet the challenging demands of many automatic transmissions. Its responsive low-temperature fluidity is beneficial in both electronic and hydraulic controlled transmissions and transaxles. Recommended for use in the following applications: MERCON*, DEXRON*-III, Ford M2C138-CJ and M2C166-H, Allison C-4 and TES-389, and Caterpillar TO-2.

Product Features:

Formulated with premium base stocks and advanced additive technology to meet the challenging demands of automatic transmissions
Enhanced anti-shudder protection for smooth shifting and maximum power transfer
Developed with anti-wear technology to help improve transmission durability
Engineered with a proprietary blend of base oils and advanced additives to provide better oil flow at low temperatures and greater film protection at higher temperatures

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$38.99

Center support bearings or Carrier Support Bearings are used when the driveshaft is split into two sections. It serves as a junction on the drive shaft between the transmission and the differential allowing the driveshaft to flex, relieving stress on other drive line components. Each part is engineered and designed to OE Standards. Applicable to CHEV 60-02; DODGE 64-66; FORD 75-15; GMC 60-02;. Please verify your application.

Product Features:

MAXIMUM VIBRATION DAMPENING: Rubber cushion is made of high grade rubber that ensures maximum dampening of vibration and the ability to absorb over loads.
HEAVY GAUGE STEEL FRAME: The housing frame is made from heavy gauge steel with durability that extends the service life.
READY TO INSTALL: Most center supports include a sealed bearing and dust shield and are ready to install.
For Years: 1960-2015
Weight approx: 3 Lbs
BEARING ID / BORE: 1.5750 INCH / 40 MM
CENTERLINE: 2.28 INCH / 58 MM
MOUNT WIDTH: 6.62 INCH / 168 MM
NO STUDS

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$21.49

Center support bearings or Carrier Support Bearings are used when the driveshaft is split into two sections. It serves as a junction on the drive shaft between the transmission and the differential allowing the driveshaft to flex, relieving stress on other drive line components. Each part is engineered and designed to OE Standards. Applicable to AUTOCAR 84-88; CHECKER 55-82; CHEV 60-12; DODGE 57-02; FORD 55-10; GMC 63-07; INTL 57-02; ISUZU 96-01; KW 81-18; MACK 80-90; MAZDA 87-94; MITS 87-09; OLDS 90-01; PLYM 80-83; PTRB 65-83; WHGM 88-95; WHIT 81-88;. Please verify your application.

Product Features:

MAXIMUM VIBRATION DAMPENING: Rubber cushion is made of high grade rubber that ensures maximum dampening of vibration and the ability to absorb over loads.
HEAVY GAUGE STEEL FRAME: The housing frame is made from heavy gauge steel with durability that extends the service life.
READY TO INSTALL: Most center supports include a sealed bearing and dust shield and are ready to install.
For Years: 1955-2018
Weight approx: 3 Lbs
BEARING ID / BORE: 1.3780 INCH / 35 MM
CENTERLINE: 2.28 INCH / 58 MM
MOUNT WIDTH: 6.62 INCH / 168 MM
STYLE: ROUND FRAME
COMPLETE MOUNT

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$556.99

Product Features:

Each LuK GearBOX contains all the OE quality bearings needed for a professional transmission repair
LuK Differential Bearing Kits are designed to meet or exceed OEM requirements. This will ensure customer satisfaction.
LuK Differential Bearing Kits contain the bearings and seals needed to complete the job.
LuK Differential Bearing Kits include wear parts such as seals, O-rings, shaft sealing rings, support bearings and spare parts where necessary for eliminating the specific cause of failure.

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$191.99

Motive Gear Differential Bearing Kits Include Front & Rear Pinion Bearing, Pinion Seal, Carrier Bearings, Pilot Bearing Where Applicable, Gear Marking Compound, Crush Sleeve, Pinion Nut, Brush, Thread Locking Compound And Cover Gasket Or Rtv

Product Features:

BRG. MSTR KIT – DANA 70 U

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$152.99

Set-up bearing (one bearing). HM803149. No return.

Product Features:

Set up bearing
Fits HM803149 pinion bearing
Easily slips on and off pinion journal to allow for pinion depth adjustment

from

$153.99

Set-up bearing (one bearing). HM803146. No return.

Product Features:

Set up bearing
Fits HM803146 pinion bearing
Easily slips on and off pinion journal to allow for pinion depth adjustment

from

$36.99

Manufactured with premium-grade steel, National taper bearing cones feature crowned raceways and rollers to ensure even load distribution.

Product Features:

PREMIUM MATERIALS – Precision manufactured using premium-grade steel for outstanding durability and performance
SMOOTH ROTATION – Crowned raceways and rollers for even load distribution
OE-STYLE DESIGN – Engineered to meet OE specifications
COMPREHENSIVE COVERAGE – Industry-leading coverage for domestic and import applications
RIGOROUS TESTING – Comprehensive testing throughout design and development processes by National engineers for quality you can count on

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$9.99

Product Features:

Cross pin bolt for Dana Spicer 60 with c-clip axles

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$7.79

Manufactured with premium-grade steel, National taper bearing cups feature crowned raceways to ensure even load distribution.

Product Features:

PREMIUM MATERIALS – Precision manufactured using premium-grade steel for outstanding durability and performance
SMOOTH ROTATION – Crowned raceways for even load distribution
OE-STYLE DESIGN – Engineered to meet OE specifications
COMPREHENSIVE COVERAGE – Industry-leading coverage for domestic and import applications
RIGOROUS TESTING – Comprehensive testing throughout design and development processes by National engineers for quality you can count on

from

$18.49

Value-priced bearing meets all cataloged application requirements.

Product Features:

Brand may vary by location

from

$9.99

National Oil Seals & Bearings offer a full line of premium oil seals and bearings.

Product Features:

Premium bearing design matches OEM specifications
Precision manufactured using premium-grade steel for outstanding durability and performance
Crowned raceways and rollers to ensure even load distribution for maximum life
Industry leading coverage
Professional technicians know they can depend on National

from

$27.99

Spindle nut, 2.065″ I.D., six slots. This replaces Spicer part number 36635.

Product Features:

Spindle nut
6 slots
2.065″ I.D.

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$40.49

This spindle nut is designed to match the fit and function of the original part on specified vehicles. Made of quality materials, it is engineered for reliable performance.

Product Features:

Direct replacement – this spindle nut matches the fit and function of the factory part on specified years, makes and models
Ideal solution – this nut is a reliable replacement for an original part that is missing or has failed due to fatigue
Durable construction – this part is made from quality materials to ensure reliable performance and long service life
Trustworthy quality – backed by team of product experts in the United States and more than a century of automotive experience

from

$39.99

This spindle nut is designed to match the fit and function of the original part on specified vehicles. Made of quality materials, it is engineered for reliable performance.

Product Features:

Direct replacement – this spindle nut matches the fit and function of the factory part on specified years, makes and models
Ideal solution – this nut is a reliable replacement for an original part that is missing or has failed due to fatigue
Durable construction – this part is made from quality materials to ensure reliable performance and long service life
Trustworthy quality – backed by team of product experts in the United States and more than a century of automotive experience

from

$3.49

This spindle nut is designed to match the fit and function of the original part on specified vehicles. Made of quality materials, it is engineered for reliable performance.

Product Features:

Direct replacement – this spindle nut matches the fit and function of the factory part on specified years, makes and models
Ideal solution – this nut is a reliable replacement for an original part that is missing or has failed due to fatigue
Durable construction – this part is made from quality materials to ensure reliable performance and long service life
Trustworthy quality – backed by team of product experts in the United States and more than a century of automotive experience

from

$16.99

With advanced load-carrying capacity and compact design, tapered roller bearings are used in wheel bearings, transmissions, differentials, transfer cases and other miscellanous applications. FAG manufacturers over 100 million tapered roller bearings annually.

Product Features:

High-precision and High-quality components used in all KITs
Coverage of classic and new high-tech solutions for the best system coverage

Upgrade your 2021 Ford E-350 Super Duty with Top-Quality Drivetrains

When it comes to maintaining or upgrading your 2021 Ford E-350 Super Duty, nothing is more important than using high-quality OEM or aftermarket parts that you can trust. Whether you’re repairing damage to your Ford or enhancing its overall performance, Drivetrains are key to keeping your E-350 Super Duty functioning at its best. At Advance Auto Parts, we offer a wide selection of 27 Drivetrains for the 2021 Ford E-350 Super Duty, designed to meet your needs without breaking the bank. From Transfer Case replacements to Universal Joints upgrades, we’ve got you covered with parts that fit your vehicle perfectly and ensure long-lasting performance.

Affordable Prices and Wide Selection

Shopping for Drivetrains for any vehicle can be a hassle, especially if you’re on a budget. But with Advance Auto Parts, you can find high-quality Drivetrains for your 2021 Ford E-350 Super Duty at great prices. Our Drivetrains inventory for this model ranges from just $3.49 to $556.99, with an average price of $51.52. Our 27 Drivetrains in stock come from 10 trusted brands, so you’re sure to find the right part for your 2021 Ford E-350 Super Duty without overspending.

Top Brands and High Customer Satisfaction

Advance Auto Parts takes pride in offering only the best brands in the automotive industry. For your 2021 Ford E-350 Super Duty, we stock popular OEM and aftermarket Drivetrains from top names like Valvoline, Moog, Dorman, and more. Valvoline Drivetrains start at just $14.49 and boast an impressive 4.8 stars average rating from customers. Moog and Dorman also bring quality to the table, with Drivetrains available starting at $3.49, and at an average 4.5 stars rating. With 1,430 customer reviews and counting, our 2021 Ford E-350 Super Duty Drivetrains have a strong track record of reliability, ensuring you can trust your purchase.

Explore Related Parts and More

While you’re here, don’t forget to check out other essential categories that go hand in hand with Drivetrain upgrades. Explore related part types like Batteries and Chargers, Oil and Lubricants and more to make sure your 2021 Ford E-350 Super Duty is always ready to roll. We’re committed to providing you with everything you need to keep your E-350 Super Duty in top shape, all in one place. Start shopping confidently below for your 2021 Ford E-350 Super Duty!

Best-Selling Transfer Cases for 2021 Ford E-350 Super Duties

Enhance the driving experience in your Ford with 2 quality Transfer Case components, starting at $16.99.

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from

$17.49

National Oil Seals & Bearings offer a full line of premium oil seals and bearings.

Product Features:

Premium bearing design matches OEM specifications
Precision manufactured using premium-grade steel for outstanding durability and performance
Crowned raceways and rollers to ensure even load distribution for maximum life
Industry leading coverage
Professional technicians know they can depend on National

from

$16.99

High-precision and High-quality components used in all KITs
Coverage of classic and new high-tech solutions for the best system coverage

Most Popular 2021 Ford E-350 Super Duty Universal Joints

Customize your Ford with 9 Universal Joints products like U-Joints, all priced under $59.99.

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from

$54.99

from

$59.99

Product Features:

BUILT TO LAST – Rugged design specifically engineered for applications with higher torque and horsepower
COMPREHENSIVE COVERAGE – Available for foreign and domestic nameplates
CORROSION PROTECTION – Exclusive MICRO SHIELD coating protects against rust and corrosion
GREASABLE DESIGN – Bearing cups feature a radial design to allow 360 Degrees lubricant distribution to all bearing surfaces
KEEPS DIRT OUT – Abrasion-resistant nitrile seals provide ideal grease retention and protection from under-vehicle contaminants
RIGOROUS TESTING – Comprehensive testing throughout design and development processes by MOOG engineers for quality you can count on
STRONG AND DURABLE – Bearing cups are cold-forged, case-hardened and precision ground while steel cross is forged and carburized heat treated for strength and durability

from

$46.99

Product Features:

COMPREHENSIVE COVERAGE – Available for foreign and domestic nameplates
GREASABLE DESIGN – Greasable u-joints allow for new grease to flush out contaminants and moisture
KEEPS DIRT OUT – Nitrile rubber grease seals use a compressed double lip design for effective protection against contaminants
RIGOROUS TESTING – Comprehensive testing throughout design and development processes by MOOG engineers for quality you can count on
STRONG AND DURABLE – Bearing cups are cold-forged, case-hardened and precision ground while steel cross is forged and carburized heat treated for strength and durability
Cross forging shape and flash provide easier installation and high strength

from

$37.99

Product Features:

BUILT TO LAST – Rugged design specifically engineered for applications with higher torque and horsepower
COMPREHENSIVE COVERAGE – Available for foreign and domestic nameplates
CORROSION PROTECTION – Exclusive MICRO SHIELD coating protects against rust and corrosion
GREASABLE DESIGN – Bearing cups feature a radial design to allow 360 Degrees lubricant distribution to all bearing surfaces
KEEPS DIRT OUT – Abrasion-resistant nitrile seals provide ideal grease retention and protection from under-vehicle contaminants
RIGOROUS TESTING – Comprehensive testing throughout design and development processes by MOOG engineers for quality you can count on
STRONG AND DURABLE – Bearing cups are cold-forged, case-hardened and precision ground while steel cross is forged and carburized heat treated for strength and durability

from

$15.99

Driveworks Universal Joints are designed to meet or exceed OE fit, form, and function. These universal joints are set to provide superior quality and easy installation. Driveworks Universal Joints are constructed from quality materials for extended durability. Driveworks Universal Joints are pre-lubricated with premium grease to provide a longer service life. The grease fittings are pre-installed to allow for easy maintenance (where applicable).

Product Features:

The cross is hot forged for the higher torque and horsepower
The bearing cups are made by cold forging, having higher strength and better rigidity
Bearing cups allow 360 lubricant distribution to bearing surfaces, and are precision-ground for maximum load-carrying capabilities
Lubrication grooves are designed to ensure grease penetration to entire journal and needle bearings
Grease fitting in the cross allows for easy maintenance and the flexible use of the whole assembly
Snap rings are held to strict tolerances to ensure proper cup position and retention
Nitrile rubber seals to optimize grease retention and reduce contamination

from

$37.99

Product Features:

BUILT TO LAST – Rugged design specifically engineered for applications with higher torque and horsepower
COMPREHENSIVE COVERAGE – Available for foreign and domestic nameplates
CORROSION PROTECTION – Exclusive MICRO SHIELD coating protects against rust and corrosion
KEEPS DIRT OUT – Abrasion-resistant nitrile seals provide ideal grease retention and protection from under-vehicle contaminants
RIGOROUS TESTING – Comprehensive testing throughout design and development processes by MOOG engineers for quality you can count on
STRONG AND DURABLE – Bearing cups are cold-forged, case-hardened and precision ground while steel cross is forged and carburized heat treated for strength and durability

from

$41.99

Product Features:

BUILT TO LAST – Rugged design specifically engineered for fleets, off-highway and commercial vehicles
STRONG AND DURABLE – Bearing cups are cold-formed, case-hardened and precision ground for strength and durability
KEEPS DIRT OUT – Abrasion-resistant nitrile seals provide ideal grease retention and protection from under-vehicle contaminants
GREASEABLE DESIGN – Drilled and tapped grease fitting holes for easy servicing and cross trunnions with large grease reservoirs with radial grease channels for grease distribution
INHIBITS PREMATURE WEAR – Cross trunnions ground to a 15-25 RMS finish for a smooth surface free of microscopic grooves that can cause premature wear
RELIABLE PERFORMANCE – Internal anti-drainback valve integrated into thrust washer controls lubrication flow and prevents dry startup
RIGOROUS TESTING – Comprehensive testing throughout design and development processes by MOOG engineers for quality you can count on

from

$46.99

The cross is hot forged for the higher torque and horsepower
The bearing cups are made by cold forging, having higher strength and better rigidity
Bearing cups allow 360 lubricant distribution to bearing surfaces, and are precision-ground for maximum load-carrying capabilities
Lubrication grooves are designed to ensure grease penetration to entire journal and needle bearings
Grease fitting in the cross allows for easy maintenance and the flexible use of the whole assembly
Snap rings are held to strict tolerances to ensure proper cup position and retention
Nitrile rubber seals to optimize grease retention and reduce contamination

from

$55.99

Top Picks for 2021 Ford E-350 Super Duty Drive Shafts and Axles

Upgrade Ford E-350 Super Duties with top-quality Drive Shafts and Axles parts, including 5 OEM and aftermarket selections for your 2021 model.

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from

$45.99

OE engineering and field tested experience is why the Spicer brand is the most trusted in the industry.
Forged with high-quality steel, these u-joints are heat treated and case-hardened with precision to specific levels, ensuring optimal strength and durability.
The process of precision grinding the seal and bearing surfaces helps to improve the life of the seal and bearing.
Zerk allows for lubricating at regular intervals to help extend the life of the part.

from

$22.49

Direct replacement – this engine mount bolt matches the fit and function of the factory part on specified years, makes and models
Ideal solution – this drive shaft bolt is a reliable replacement for an original part that is missing or has failed due to fatigue
Durable construction – this part is made from quality materials to ensure reliable performance and long service life
Trustworthy quality – backed by team of product experts in the United States and more than a century of automotive experience

from

$9.99

National Oil Seals & Bearings offer a full line of premium oil seals and bearings.

Product Features:

Premium bearing design matches OEM specifications
Precision manufactured using premium-grade steel for outstanding durability and performance
Crowned raceways and rollers to ensure even load distribution for maximum life
Industry leading coverage
Professional technicians know they can depend on National

from

$38.99

MAXIMUM VIBRATION DAMPENING: Rubber cushion is made of high grade rubber that ensures maximum dampening of vibration and the ability to absorb over loads.
HEAVY GAUGE STEEL FRAME: The housing frame is made from heavy gauge steel with durability that extends the service life.
READY TO INSTALL: Most center supports include a sealed bearing and dust shield and are ready to install.
For Years: 1960-2015
Weight approx: 3 Lbs
BEARING ID / BORE: 1.5750 INCH / 40 MM
CENTERLINE: 2.28 INCH / 58 MM
MOUNT WIDTH: 6.62 INCH / 168 MM
NO STUDS

from

$27.99

Product Features:

Ideal replacement – this axle shaft flange seal directly replaces the original gasket without having to visit the dealer
Required for routine service – this gasket should be replaced every time work is performed at the axle flange
Durable construction – this axle shaft flange gasket is made of tough, durable materials for leak-free performance
Quality tested – this flange gasket has been designed and tested for a guaranteed fit

In-Demand Spindles for 2021 Ford E-350 Super Duties

Select from 4 premium Spindles parts for your 2021 Ford E-350 Super Duty, with prices ranging from $3.49 to $40.49.

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$3.49

This spindle nut is designed to match the fit and function of the original part on specified vehicles. Made of quality materials, it is engineered for reliable performance.

Product Features:

Direct replacement – this spindle nut matches the fit and function of the factory part on specified years, makes and models
Ideal solution – this nut is a reliable replacement for an original part that is missing or has failed due to fatigue
Durable construction – this part is made from quality materials to ensure reliable performance and long service life
Trustworthy quality – backed by team of product experts in the United States and more than a century of automotive experience

from

$4.79

This spindle nut is designed to match the fit and function of the original part on specified vehicles. Made of quality materials, it is engineered for reliable performance.

Product Features:

Direct replacement – this spindle nut matches the fit and function of the factory part on specified years, makes and models
Ideal solution – this nut is a reliable replacement for an original part that is missing or has failed due to fatigue
Durable construction – this part is made from quality materials to ensure reliable performance and long service life
Trustworthy quality – backed by team of product experts in the United States and more than a century of automotive experience

from

$40.49

This spindle nut is designed to match the fit and function of the original part on specified vehicles. Made of quality materials, it is engineered for reliable performance.

Product Features:

Direct replacement – this spindle nut matches the fit and function of the factory part on specified years, makes and models
Ideal solution – this nut is a reliable replacement for an original part that is missing or has failed due to fatigue
Durable construction – this part is made from quality materials to ensure reliable performance and long service life
Trustworthy quality – backed by team of product experts in the United States and more than a century of automotive experience

from

$39.99

This spindle nut is designed to match the fit and function of the original part on specified vehicles. Made of quality materials, it is engineered for reliable performance.

Product Features:

Direct replacement – this spindle nut matches the fit and function of the factory part on specified years, makes and models
Ideal solution – this nut is a reliable replacement for an original part that is missing or has failed due to fatigue
Durable construction – this part is made from quality materials to ensure reliable performance and long service life
Trustworthy quality – backed by team of product experts in the United States and more than a century of automotive experience

Most Sold 2021 Ford E-350 Super Duty Differentials

Explore our best-selling Ford parts for the 2021 E-350 Super Duty among 7 OEM and aftermarket options starting from $8.89.

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from

$41.99

Royal Purple Motor Oil is a specially formulated multi viscocity oil for use in gasoline and diesel engines of all types from cars and trucks to SUVs, motorcycles and boats. Royal Purple(R) Motor Oil with Synerlec(R) additive technology reduces friction, which results in a 1-3 percent increase in horsepower, lowers operating temperatures, provides superior corrosion protection, improves fuel economy, reduces emissions and extends oil life. A.P.I. Certified.

Product Features:

Better wear protection
Increased fuel efficiency
Better protection of the expensive catalytic emission system
Improved compatibility with fuels containing ethanol
Superior corrosion protection
Meets ILSAC GF-5 and Dexos1 performance requirements

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$14.49

Valvoline DEXRON-VI/MERCON LV ATF is a full-synthetic transmission fluid formulated with advanced additive technology to meet and exceed the requirements of the General Motors DEXRON-VI specification. It is officially licensed and approved by GM and is fully back-serviceable and can be used wherever DEXRON-II and/or DEXRON-III are recommended. Recommended for use in the following applications: DEXRON-VI, DEXRON-III, DEXRON-II, and Allison C-4.

Product Features:

Formulated with full-synthetic base stocks and advanced additive technology to meet the challenging demands of automatic transmissions
Enhanced anti-shudder protection for smooth shifting and maximum power transfer
Developed with anti-wear technology to help improve transmission durability
Engineered with a proprietary blend of base oils and advanced additives to provide better oil flow at low temperatures and greater film protection at higher temperatures

from

$69.99

Valvoline SAE 75W-140 Full Synthetic Gear Oil provides the ultimate gear protection in hypoid rear differentials and non-synchronized manual transmissions. Engineered to outperform, our formulation provides exceptional high and low temperature protection and excellent thermal stability, especially in demanding driving situations such as towing and off-roading. It contains an extreme pressure additive for better load carrying capacity and wear resistance, a limited slip additive for optimal clutch pack performance, and an anti-foaming agent for better lubrication and service life. It’s recommended for conventional rear axles and transmissions requiring EP gear lubes under high speed, high load, high torque and high horsepower conditions.

Product Features:

EXCEPTIONAL HIGH AND LOW TEMPERATURE PROTECTION ranging from -22F to 390F degrees
REDUCES CHATTERING AND PROTECTS GEAR TEETH from oxidation, rust, and wear
FIGHTS CORROSION AND RUST with emulsifying agents and safeguards against impurities, oxidation and thermal breakdown
MEETS THE DEMANDS OF CONVENTIONAL AND LIMITED SLIP REAR DIFFERENTIALS where API GL-5 is specified, as well as non-synchronized manual transmissions that require API GL-4
MEETS OR EXCEEDS PERFORMANCE REQUIREMENTS for Ford M2C-192A, GM 12346140, Chrysler MS-8985 and API GL-5

from

$11.99

Value-priced bearing meets all cataloged application requirements.

Product Features:

Brand may vary by location

from

$18.99

We’ve squeezed innovation into every ounce of Valvoline FlexFill SAE 75W-90 Full Synthetic Gear Oil, the ultimate gear protection in hypoid rear differentials and non-synchronized manual transmissions. Our unique new flexible pouch makes getting into the tightest places to lubricate gears easier than ever and with less waste. The superior detergent package-based formulation contains fully synthetic basestocks and special additives that help protect parts from rust and corrosion while providing exceptional high and low temperature protection and excellent thermal stability, especially in demanding driving situations such as towing and off-roading. It contains an extreme pressure additive for better load carrying capacity, wear resistance additives that assist in protecting gear teeth, a limited slip additive for optimal clutch pack performance, and an anti-foaming agent for better lubrication and service life. Valvoline FlexFill SAE 75W-90 Full Synthetic Gear Oil is recommended for use in axle applications requiring factory-fill or drain-and-fill levels for limited slip performance.

Product Features:

FLEXIBLE POUCH FOR EASIER USE WITH LESS WASTE in tight, hard to reach undercarriage situations.
EXCEPTIONAL HIGH AND LOW TEMPERATURE PROTECTION ranging from -30F to 300F degrees for dependable coverage year-round
REDUCES CHATTERING AND PROTECTS GEAR TEETH from oxidation, rust, and wear
MEETS THE DEMANDS OF CONVENTIONAL AND LIMITED SLIP REAR DIFFERENTIALS where API GL-5 is specified, as well as non-synchronized manual transmissions that require API GL-4 or MT-1 fluid
MEETS OR EXCEEDS PERFORMANCE REQUIREMENTS for Mack GO-H and GO-J; API GL-5 and API MT-1; MIL-PRF-2105E; and SAE J2360

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$556.99

Product Features:

Each LuK GearBOX contains all the OE quality bearings needed for a professional transmission repair
LuK Differential Bearing Kits are designed to meet or exceed OEM requirements. This will ensure customer satisfaction.
LuK Differential Bearing Kits contain the bearings and seals needed to complete the job.
LuK Differential Bearing Kits include wear parts such as seals, O-rings, shaft sealing rings, support bearings and spare parts where necessary for eliminating the specific cause of failure.

from

$8.89

High-precision and High-quality components used in all KITs
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Top-Rated Drivetrains Brands For Your 2021 Ford E-350 Super Duty

Shop for the best-rated brands offering Drivetrains and other products for your 2021 Ford E-350 Super Duties. Below you’ll find some of our best rated Drivetrains from Valvoline, Moog, and Dorman, and more. Drivetrains from these brands that fit a 2021 E-350 Super Duty start at just $3.49 and are rated as high as 4.8 stars. OEM and aftermarket Drivetrains don’t get more top quality, durable, and affordable than from the brands below.

Popular Valvoline 2021 Ford E-350 Super Duty Drivetrains

When it comes to maintaining or upgrading your 2021 Ford E-350 Super Duty, using quality Drivetrains is essential to ensure durability and a perfect fit. Valvoline ticks all of those boxes. We offer a wide selection of Valvoline Drivetrains, specifically designed for the 2021 Ford E-350 Super Duty. With over 2 Valvoline brand Drivetrains in stock, you’re sure to find what you need. The prices for these top-notch parts start as low as $14.49, with an average price of just $42.24. Plus, with over 366 customer reviews and an average rating of 4.8 stars, you can trust that our Valvoline Drivetrains will get the job done right. Choose Advance Auto Parts for reliability, quality, and expert-approved parts that keep your vehicle running strong.

from $69.99

(364)

SynPower Transmission & Differential Gear Oil: Full Synthetic 75W-140, 1 Gallon

“Happy with purchase”

from $14.49

(2)

DEXRON – VI ATF Full Synthetic Automatic Transmission Fluid, 1 Quart

“I’ve used this in my 2005 2500HD since I bought the truck with 20k on it now at 280k changed every other year maybe 40k I’d put on in two years, I pu”

Popular Moog 2021 Ford E-350 Super Duty Drivetrains

Moog auto parts is one of the highest quality Drivetrain brands in the market. Any 2021 Ford E-350 Super Duty owner should feel confident when installing genuine Moog parts in their vehicle. To ensure the best fit and performance for your 2021 E-350 Super Duty, Advance Auto Parts carries a full inventory of 3 Moog Drivetrains. Plus you will be keeping your Ford in peak condition while saving money because prices on these Moog Drivetrains range from $37.99 to $59.99, plus, with more than 100 customer reviews and an impressive 4.5 stars average rating, you can be confident the Fram Drivetrains below will deliver on both quality and value.

from $59.99

(39)

Greaseable Super Strength Universal Joint

“quality product”

from $46.99

(20)

Greaseable Premium Universal Joint

“Great!”

from $37.99

(41)

Greaseable Super Strength Universal Joint

“Easy install and great way to have sting durability with access to grease points”

FAQs for 2021 Ford E-350 Super Duty Drivetrains

Which Drivetrains are best-sellers for 2021 Ford E-350 Super Duties?

Out of 27 Drivetrains that fit 2021 Ford E-350 Super Duties, the following parts are the top sellers:

High Performance 5W-30 Synthetic Engine Oil, Better Wear Protection, 5 Quart (11150912) – $41.99
Flex Fill Transmission & Differential Gear Oil: Full Synthetic 75W-90, 1 Quart (12507273) – $18.99
Greaseable Super Strength Universal Joint (10086981) – $59.99

What’s the price range for 2021 Ford E-350 Super Duty Drivetrains?

Drivetrain prices for the 2021 Ford E-350 Super Duty start at $3.49 and go up to $556.99 for the most premium parts.

What’s the average price of a Drivetrain for a 2021 Ford E-350 Super Duty?

The average price for Drivetrains for the 2021 Ford E-350 Super Duty is $51.52. Keep in mind the variety of part types within our Drivetrain category so you are likely to find a wide range of prices across a variety of parts and components.

Does Advance Auto Parts sell Drivetrains for other Ford E-350 Super Duty model years?

Yes, we currently carry Drivetrains for 23 model years of Ford E-350 Super Duties between 2000 and 2025. Drivetrains are bought most frequently for the following model years: 2022, 2019, 2018, 2017, 2016, 2015, 2014, 2013, and 2012.

What are the cheapest Drivetrains for my 2021 Ford E-350 Super Duty?

The cheapest 2021 Ford E-350 Super Duty Drivetrains we carry in stock are:

Standard Spindle Nut 3/4 In.-16 Hex Size 1-1/16 In. (21260547) – $3.49
Standard Spindle Nut 3/4 In.-16 Hex Size 1-1/16 In. (sold by each) (22149122) – $4.79
Cup (50206233) – $8.89
Bearings (3272400) – $9.99
Taper Bearing Cone (5050049) – $11.99

What are the top-rated Drivetrains that fit the 2021 Ford E-350 Super Duty?

Out of 1,430 reviews by customers, our 2021 Ford E-350 Super Duty Drivetrains have an average customer rating of . These are some of the highest-rated Drivetrain types for the 2021 Ford E-350 Super Duty and their top-rated products:

Universal Joints
- Universal Joint (10855000) – $54.99
- Greaseable Premium Universal Joint (10086907) – $46.99
- Greaseable Super Strength Universal Joint (10086981) – $59.99
Spindles
- Universal Joint (10855000) – $54.99
- Greaseable Premium Universal Joint (10086907) – $46.99
- Greaseable Super Strength Universal Joint (10086981) – $59.99
Differentials
- Universal Joint (10855000) – $54.99
- Greaseable Premium Universal Joint (10086907) – $46.99
- Greaseable Super Strength Universal Joint (10086981) – $59.99

What types of Drivetrains do you sell for my 2021 Ford E-350 Super Duty?

As of 11/2/25, these are some of the most in-demand types of Drivetrains for a 2021 Ford E-350 Super Duty:

Can I get help with 2021 Ford E-350 Super Duty Drivetrain orders?

Contact our customer support team, by chat or phone, through the help desk page, where you can find instant answers about Ford Drivetrains and more.

What is your return policy for Ford E-350 Super Duty Drivetrains?

Advance Auto Parts keeps returns simple. For new Ford E-350 Super Duty Drivetrains and accessories, your online orders can be returned, in their original condition, within 45 days. For requirements, see the returns page.

2021 Ford E-350 Super Duty Drivetrains

National – Bearings (Part No.15101)

Spicer – Universal Joint (Part No.5-1350X)

Spicer – Universal Joint, Greaseable 1350 Series (Part No.5-178X)

MOOG Driveline Products – Greaseable Premium Universal Joint (Part No.330)

Yukon Gear – 1410 U/Joint With Zerk Fitting (Part No.42009)

Dorman – Axle Flange Gasket Kit (Part No.926-880)

Dorman – Help – Driveshaft Flange Bolts (Part No.80992)

Yukon Gear – Redline Synthetic "Shock Proof" Oil With Positraction Additive – 4 Quarts (Part No.15005)

Valvoline – DEX/MERC ATF Conventional Automatic Transmission Fluid, 1 Quart (Part No.798153)

Anchor – Center Support Bearing Motor Mount: Center, 1 Piece (Part No.6053)

Anchor – Center Support Bearing Motor Mount: Center, 1 Piece (Part No.6056)

LuK – Differential Repair Kit (Part No.GDK332-HD)

Motive Gear – Differential Master Bearing Kit – Koyo (Part No.R70URMK)

Yukon Gear – Set Up Bearing (Part No.56041)

Yukon Gear – Set Up Bearing (Part No.56067)

National – Tapered Roller Bearing Cone (Part No.HM803149)

Yukon Gear – 9.25" Chrysler, Dana 60 Semi-Float X/P Bolt, 80 & Up, 5/16" Head, Tapered Shoulder (Part No.33238)

National – Bearing Race (Part No.LM102910)

Driveworks – Tapered Cone Wheel Bearing Assembly (Part No.S-387-AS)

National – Bearings (Part No.15245)

Yukon Gear – Spindle Nut, 2.065" I.D., Six Slots (Part No.33484)

Dorman – Spindle Nut 2 In.-16 Hex Size 3 In. (sold by each) (Part No.615-133)

Dorman – Spindle Nut 2 In.-16 Hex Size 3 In. (Part No.615-133.1)

Dorman – Standard Spindle Nut 3/4 In.-16 Hex Size 1-1/16 In. (Part No.615-072.1)

FAG US – Cup (Part No.LM104911)

National – Bearings (Part No.15101)

FAG US – Cup (Part No.LM104911)

Spicer – Universal Joint (Part No.5-1410X)

MOOG Driveline Products – Greaseable Super Strength Universal Joint (Part No.295)

MOOG Driveline Products – Greaseable Premium Universal Joint (Part No.330)

MOOG Driveline Products – Greaseable Super Strength Universal Joint (Part No.232)

Driveworks – Universal Joint (Part No.DW-331)

MOOG Driveline Products – Non-Greaseable Super Strength Universal Joint (Part No.231)

MOOG Driveline Products – Greaseable Premium Universal Joint (Part No.331)

Driveworks – Universal Joint (Part No.DW-330)

Spicer – Universal Joint (Part No.5-1410-1X)

Spicer – Universal Joint, Greaseable 1410 Series (Part No.5-160X)

Dorman – Help – Driveshaft Flange Bolts (Part No.80992)

National – Bearings (Part No.15245)

Anchor – Center Support Bearing Motor Mount: Center, 1 Piece (Part No.6053)

Dorman – Axle Flange Gasket Kit (Part No.926-880)

Dorman – Standard Spindle Nut 3/4 In.-16 Hex Size 1-1/16 In. (Part No.615-072.1)

Dorman – Standard Spindle Nut 3/4 In.-16 Hex Size 1-1/16 In. (sold by each) (Part No.615-072)

Dorman – Spindle Nut 2 In.-16 Hex Size 3 In. (sold by each) (Part No.615-133)

Dorman – Spindle Nut 2 In.-16 Hex Size 3 In. (Part No.615-133.1)

Royal Purple – High Performance 5W-30 Synthetic Engine Oil, Better Wear Protection, 5 Quart (Part No.51530)

Valvoline – DEXRON – VI ATF Full Synthetic Automatic Transmission Fluid, 1 Quart (Part No.822405)

Valvoline – SynPower Transmission & Differential Gear Oil: Full Synthetic 75W-140, 1 Gallon (Part No.887344)

Driveworks – Taper Bearing Cone (Part No.S-LM-104949)

Valvoline – Flex Fill Transmission & Differential Gear Oil: Full Synthetic 75W-90, 1 Quart (Part No.889785)

LuK – Differential Repair Kit (Part No.GDK332-HD)

FAG US – Cup (Part No.15245)