2010 Lexus RX450h Drivetrains

Essential Drivetrains for 2010 Lexus RX450hs

National – Transfer Case Output Shaft Seal (Part No.711075)

Transfer Case Output Shaft Seal

from

$12.99
National has built a reputation as one of the most respected names in the industry. We have offered premium sealing solutions for more than 75 years. Our design team keeps pace with the industry and provides advanced solutions for today’s vehicles.

Product Features:
  • Design type: spring loaded; multi-lip
  • Temperature range: -20 Deg. F to 300 Deg. F / -29 Deg. C to 49 Deg. C
  • Resistance to EP lubricants
  • Low swell in hydrocarbon fluids
  • Delivers quality and reliable performance for every type of repair
See More

National – Transfer Case Output Shaft Seal (Part No.710954)

Transfer Case Output Shaft Seal

from

$12.79
National has built a reputation as one of the most respected names in the industry. We have offered premium sealing solutions for more than 75 years. Our design team keeps pace with the industry and provides advanced solutions for today’s vehicles.

Product Features:
  • Design type: spring loaded; multi-lip
  • Temperature range: -20 Deg. F to 300 Deg. F / -29 Deg. C to 49 Deg. C
  • Resistance to EP lubricants
  • Low swell in hydrocarbon fluids
  • Delivers quality and reliable performance for every type of repair
See More

Dorman – Spindle Nut M22-1.50 Hex Star Pattern (sold by each) (Part No.615-224)

Spindle Nut M22-1.50 Hex Star Pattern (sold by each)

from

$10.99
This spindle nut is designed to match the fit and function of the original part on specified vehicles. Made of quality materials, it is engineered for reliable performance.

Product Features:
  • Direct replacement – this spindle nut matches the fit and function of the factory part on specified years, makes and models
  • Ideal solution – this nut is a reliable replacement for an original part that is missing or has failed due to fatigue
  • Durable construction – this part is made from quality materials to ensure reliable performance and long service life
  • Trustworthy quality – backed by team of product experts in the United States and more than a century of automotive experience
See More

Anchor – Center Support Bearing Motor Mount: Front, 1 Piece (Part No.6083)

Center Support Bearing Motor Mount: Front, 1 Piece

from

$108.99
Center support bearings or Carrier Support Bearings are used when the driveshaft is split into two sections. It serves as a junction on the drive shaft between the transmission and the differential allowing the driveshaft to flex, relieving stress on other drive line components. Each part is engineered and designed to OE Standards. Applicable to LEXUS 01-20; TOYOTA 01-19;. Please verify your application.

Product Features:
  • MAXIMUM VIBRATION DAMPENING: Rubber cushion is made of high grade rubber that ensures maximum dampening of vibration and the ability to absorb over loads.
  • HEAVY GAUGE STEEL FRAME: The housing frame is made from heavy gauge steel with durability that extends the service life.
  • READY TO INSTALL: Most center supports include a sealed bearing and dust shield and are ready to install.
  • For Years: 2001-2020
  • Weight approx: 2 Lbs
  • BEARING ID / BORE: 1.1811 INCH / 30 MM
  • CENTERLINE: 0.10 INCH / 3 MM
  • MOUNT WIDTH: 7.00 INCH / 178 MM
  • STYLE: ROUND FRAME
  • WITH WINGS
See More

Anchor – Center Support Bearing Motor Mount: Rear, Center, 1 Piece (Part No.6082)

Center Support Bearing Motor Mount: Rear, Center, 1 Piece

from

$119.99
Center support bearings or Carrier Support Bearings are used when the driveshaft is split into two sections. It serves as a junction on the drive shaft between the transmission and the differential allowing the driveshaft to flex, relieving stress on other drive line components. Each part is engineered and designed to OE Standards. Applicable to LEXUS 99-20; TOYOTA 01-20;. Please verify your application.

Product Features:
  • MAXIMUM VIBRATION DAMPENING: Rubber cushion is made of high grade rubber that ensures maximum dampening of vibration and the ability to absorb over loads.
  • HEAVY GAUGE STEEL FRAME: The housing frame is made from heavy gauge steel with durability that extends the service life.
  • READY TO INSTALL: Most center supports include a sealed bearing and dust shield and are ready to install.
  • For Years: 1999-2020
  • Weight approx: 2 Lbs
  • BEARING ID / BORE: 1.1811 INCH / 30 MM
  • CENTERLINE: 0.10 INCH / 3 MM
  • MOUNT WIDTH: 7.00 INCH / 178 MM
  • STYLE: ROUND FRAME
  • WITH WINGS
  • WITH ELEVATED MOUNTING PLATFORM
See More

National – Shaft Repair Sleeve (Part No.99210)

Shaft Repair Sleeve

from

$47.99
National has built a reputation as one of the most respected names in the industry. We have offered premium sealing solutions for more than 75 years. Our design team keeps pace with the industry and provides advanced solutions for today’s vehicles.

Product Features:
  • Designed to repair damaged, grooved or worn shafts
  • Durable stainless steel construction for corrosion-free sealing surface that surpasses most original shaft specifications
  • Ideal for a shaft where indications of seal wear, such as tracks or grooves have developed
  • Ultra-thin construction (0.01/0.25mm wall thickness) allows original seal size to be used with minimal additional lip loading
  • Easy to install with removable flange and installation tool
See More

Carquest Premium – New CV Axle Assembly (Part No.NCV902651)

New CV Axle Assembly

from

$119.99
Manufactured to be an OE replacement, CV axles use 100% new materials and are engineered for ease of installation and long service.

Product Features:
  • All New Materials
  • Engineered for OE Fitment
  • -40 Degree Rated CV Boots
  • Moly-Blend Grease in inner and outer joints
  • New nut and mounting hardware included if required
See More

National – Drive Axle Shaft Seal (Part No.711097)

Drive Axle Shaft Seal

from

$16.99
National has built a reputation as one of the most respected names in the industry. We have offered premium sealing solutions for more than 75 years. Our design team keeps pace with the industry and provides advanced solutions for today’s vehicles.

Product Features:
  • Design type: spring loaded; multi-lip
  • Temperature range: -20 Deg. F to 300 Deg. F / -29 Deg. C to 49 Deg. C
  • Resistance to EP lubricants
  • Low swell in hydrocarbon fluids
  • Delivers quality and reliable performance for every type of repair
See More

Valvoline – Hybrid ATF Full Synthetic Automatic Transmission Fluid, 1 Quart (Part No.898795)

Hybrid ATF Full Synthetic Automatic Transmission Fluid, 1 Quart

from

$14.99
Valvoline is the No. 1 ATF brand, and now we’ve taken it to the next level with our hybrid performance fluid: Valvoline Full Synthetic Hybrid Automatic Transmission Fluid. Specifically designed for hardworking hybrids, Valvoline Full Synthetic Hybrid ATF is suitable for use in more than 95% of hybrid vehicles in operation with registered US ATF full hybrid vehicles (not including mild hybrids, traditional CVT or DCT hybrid models). Valvoline Full Synthetic Hybrid ATF is proven to maximize transmission life, and it’s compatible with copper and the coatings on copper in hybrid transmission, providing greater oxidation stability, insulation for the electrical current, and increased heat transfer capabilities to protect against transmission failure. Look for Valvoline’s complete lineup of hybrid performance fluids, including motor oil and antifreeze/coolant ¿ from the brand trusted for over 150 years.

Product Features:
  • Full synthetic hybrid ATF with Copper Care Technology, from the No. 1 ATF brand
  • Enhanced protection against corrosion that can result in hybrid transmission failure
  • Protects electrical systems maximizing transmission efficiency
  • Increased heat transfer capabilities to protect against higher temperatures produced by hybrids
See More

Idemitsu – Type TLS-LV Automatic Transmission Fluid, 1 Quart (Part No.30040096-75000C)

Type TLS-LV Automatic Transmission Fluid, 1 Quart

from

$14.49
Formulated to meet the specific requirements of Toyota, Lexus, and Scion vehicles equipped with conventional (non-CVT) transmissions that require the use of Toyota ATF WS. Recommended for service-fill in all Toyota, Lexus, and Scion automatic transmissions where ATF WS is specified. Fuel economy demands and more sophisticated electronic controls have made automatic transmissions not only more complex, but also unique to each vehicle manufacturer. Long gone are the days of having just a couple choices of automatic transmission fluid type. IDEMITSU is the factory fill Automatic Transmission Fluid (ATF) supplier to most Asian imports. IDEMITSU application-specific ATF products match the exact friction materials and performance requirements of each different vehicle model for which they are made.

Product Features:
  • Precisely engineered frictional characteristics guarantee smooth shifting and outstanding anti-shudder performance
  • Optimized viscosity and advanced friction reducing additive technology provide exceptional fuel economy performance
  • Excellent resistance to oxidation and thermal breakdown provide long fluid life and extended protection
  • Exceptional wear protection of gears and bearings
  • Provides superior deposit control and protects metal surfaces from rust and corrosion
  • Excellent seal compatibility and conditioning reduces risk of fluid leaks due to seal shrinkage, hardening and cracking
See More

Upgrade your 2010 Lexus RX450h with Top-Quality Drivetrains

When it comes to maintaining or upgrading your 2010 Lexus RX450h, nothing is more important than using high-quality OEM or aftermarket parts that you can trust. Whether you’re repairing damage to your Lexus or enhancing its overall performance, Drivetrains are key to keeping your RX450h functioning at its best. At Advance Auto Parts, we offer a wide selection of 10 Drivetrains for the 2010 Lexus RX450h, designed to meet your needs without breaking the bank. From Differential replacements to Drive Shafts and Axles upgrades, we’ve got you covered with parts that fit your vehicle perfectly and ensure long-lasting performance.

Affordable Prices and Wide Selection

Shopping for Drivetrains for any vehicle can be a hassle, especially if you’re on a budget. But with Advance Auto Parts, you can find high-quality Drivetrains for your 2010 Lexus RX450h at great prices. Our Drivetrains inventory for this model ranges from just $10.99 to $119.99, with an average price of $48.02. Our 10 Drivetrains in stock come from 6 trusted brands, so you’re sure to find the right part for your 2010 Lexus RX450h without overspending.

Explore Related Parts and More

While you’re here, don’t forget to check out other essential categories that go hand in hand with Drivetrain upgrades. Explore related part types like Oil and Lubricants, Fluids and Chemicals and more to make sure your 2010 Lexus RX450h is always ready to roll. We’re committed to providing you with everything you need to keep your RX450h in top shape, all in one place. Start shopping confidently below for your 2010 Lexus RX450h!

Best-Selling Differentials for 2010 Lexus RX450hs

Enhance the driving experience in your Lexus with 2 quality Differential components, starting at $14.49.

Idemitsu – Type TLS-LV Automatic Transmission Fluid, 1 Quart (Part No.30040096-75000C)

Type TLS-LV Automatic Transmission Fluid, 1 Quart

from

$14.49
Formulated to meet the specific requirements of Toyota, Lexus, and Scion vehicles equipped with conventional (non-CVT) transmissions that require the use of Toyota ATF WS. Recommended for service-fill in all Toyota, Lexus, and Scion automatic transmissions where ATF WS is specified. Fuel economy demands and more sophisticated electronic controls have made automatic transmissions not only more complex, but also unique to each vehicle manufacturer. Long gone are the days of having just a couple choices of automatic transmission fluid type. IDEMITSU is the factory fill Automatic Transmission Fluid (ATF) supplier to most Asian imports. IDEMITSU application-specific ATF products match the exact friction materials and performance requirements of each different vehicle model for which they are made.

Product Features:
  • Precisely engineered frictional characteristics guarantee smooth shifting and outstanding anti-shudder performance
  • Optimized viscosity and advanced friction reducing additive technology provide exceptional fuel economy performance
  • Excellent resistance to oxidation and thermal breakdown provide long fluid life and extended protection
  • Exceptional wear protection of gears and bearings
  • Provides superior deposit control and protects metal surfaces from rust and corrosion
  • Excellent seal compatibility and conditioning reduces risk of fluid leaks due to seal shrinkage, hardening and cracking
See More

Valvoline – Hybrid ATF Full Synthetic Automatic Transmission Fluid, 1 Quart (Part No.898795)

Hybrid ATF Full Synthetic Automatic Transmission Fluid, 1 Quart

from

$14.99
Valvoline is the No. 1 ATF brand, and now we’ve taken it to the next level with our hybrid performance fluid: Valvoline Full Synthetic Hybrid Automatic Transmission Fluid. Specifically designed for hardworking hybrids, Valvoline Full Synthetic Hybrid ATF is suitable for use in more than 95% of hybrid vehicles in operation with registered US ATF full hybrid vehicles (not including mild hybrids, traditional CVT or DCT hybrid models). Valvoline Full Synthetic Hybrid ATF is proven to maximize transmission life, and it’s compatible with copper and the coatings on copper in hybrid transmission, providing greater oxidation stability, insulation for the electrical current, and increased heat transfer capabilities to protect against transmission failure. Look for Valvoline’s complete lineup of hybrid performance fluids, including motor oil and antifreeze/coolant ¿ from the brand trusted for over 150 years.

Product Features:
  • Full synthetic hybrid ATF with Copper Care Technology, from the No. 1 ATF brand
  • Enhanced protection against corrosion that can result in hybrid transmission failure
  • Protects electrical systems maximizing transmission efficiency
  • Increased heat transfer capabilities to protect against higher temperatures produced by hybrids
See More

Most Popular 2010 Lexus RX450h Drive Shafts and Axles

Customize your Lexus with 4 Drive Shafts and Axles products like Drive Shaft and Axles, Axle Shaft Seals, and Center Support Bearings, all priced under $119.99.

Carquest Premium – New CV Axle Assembly (Part No.NCV902651)

New CV Axle Assembly

from

$119.99
Manufactured to be an OE replacement, CV axles use 100% new materials and are engineered for ease of installation and long service.

Product Features:
  • All New Materials
  • Engineered for OE Fitment
  • -40 Degree Rated CV Boots
  • Moly-Blend Grease in inner and outer joints
  • New nut and mounting hardware included if required
See More

Anchor – Center Support Bearing Motor Mount: Rear, Center, 1 Piece (Part No.6082)

Center Support Bearing Motor Mount: Rear, Center, 1 Piece

from

$119.99
Center support bearings or Carrier Support Bearings are used when the driveshaft is split into two sections. It serves as a junction on the drive shaft between the transmission and the differential allowing the driveshaft to flex, relieving stress on other drive line components. Each part is engineered and designed to OE Standards. Applicable to LEXUS 99-20; TOYOTA 01-20;. Please verify your application.

Product Features:
  • MAXIMUM VIBRATION DAMPENING: Rubber cushion is made of high grade rubber that ensures maximum dampening of vibration and the ability to absorb over loads.
  • HEAVY GAUGE STEEL FRAME: The housing frame is made from heavy gauge steel with durability that extends the service life.
  • READY TO INSTALL: Most center supports include a sealed bearing and dust shield and are ready to install.
  • For Years: 1999-2020
  • Weight approx: 2 Lbs
  • BEARING ID / BORE: 1.1811 INCH / 30 MM
  • CENTERLINE: 0.10 INCH / 3 MM
  • MOUNT WIDTH: 7.00 INCH / 178 MM
  • STYLE: ROUND FRAME
  • WITH WINGS
  • WITH ELEVATED MOUNTING PLATFORM
See More

National – Drive Axle Shaft Seal (Part No.711097)

Drive Axle Shaft Seal

from

$16.99
National has built a reputation as one of the most respected names in the industry. We have offered premium sealing solutions for more than 75 years. Our design team keeps pace with the industry and provides advanced solutions for today’s vehicles.

Product Features:
  • Design type: spring loaded; multi-lip
  • Temperature range: -20 Deg. F to 300 Deg. F / -29 Deg. C to 49 Deg. C
  • Resistance to EP lubricants
  • Low swell in hydrocarbon fluids
  • Delivers quality and reliable performance for every type of repair
See More

Anchor – Center Support Bearing Motor Mount: Front, 1 Piece (Part No.6083)

Center Support Bearing Motor Mount: Front, 1 Piece

from

$108.99
Center support bearings or Carrier Support Bearings are used when the driveshaft is split into two sections. It serves as a junction on the drive shaft between the transmission and the differential allowing the driveshaft to flex, relieving stress on other drive line components. Each part is engineered and designed to OE Standards. Applicable to LEXUS 01-20; TOYOTA 01-19;. Please verify your application.

Product Features:
  • MAXIMUM VIBRATION DAMPENING: Rubber cushion is made of high grade rubber that ensures maximum dampening of vibration and the ability to absorb over loads.
  • HEAVY GAUGE STEEL FRAME: The housing frame is made from heavy gauge steel with durability that extends the service life.
  • READY TO INSTALL: Most center supports include a sealed bearing and dust shield and are ready to install.
  • For Years: 2001-2020
  • Weight approx: 2 Lbs
  • BEARING ID / BORE: 1.1811 INCH / 30 MM
  • CENTERLINE: 0.10 INCH / 3 MM
  • MOUNT WIDTH: 7.00 INCH / 178 MM
  • STYLE: ROUND FRAME
  • WITH WINGS
See More

Top Picks for 2010 Lexus RX450h Transfer Cases

Upgrade Lexus RX450hs with top-quality Transfer Cases parts, including 3 OEM and aftermarket selections for your 2010 model.

National – Shaft Repair Sleeve (Part No.99210)

Shaft Repair Sleeve

from

$47.99
National has built a reputation as one of the most respected names in the industry. We have offered premium sealing solutions for more than 75 years. Our design team keeps pace with the industry and provides advanced solutions for today’s vehicles.

Product Features:
  • Designed to repair damaged, grooved or worn shafts
  • Durable stainless steel construction for corrosion-free sealing surface that surpasses most original shaft specifications
  • Ideal for a shaft where indications of seal wear, such as tracks or grooves have developed
  • Ultra-thin construction (0.01/0.25mm wall thickness) allows original seal size to be used with minimal additional lip loading
  • Easy to install with removable flange and installation tool
See More

National – Transfer Case Output Shaft Seal (Part No.711075)

Transfer Case Output Shaft Seal

from

$12.99
National has built a reputation as one of the most respected names in the industry. We have offered premium sealing solutions for more than 75 years. Our design team keeps pace with the industry and provides advanced solutions for today’s vehicles.

Product Features:
  • Design type: spring loaded; multi-lip
  • Temperature range: -20 Deg. F to 300 Deg. F / -29 Deg. C to 49 Deg. C
  • Resistance to EP lubricants
  • Low swell in hydrocarbon fluids
  • Delivers quality and reliable performance for every type of repair
See More

National – Transfer Case Output Shaft Seal (Part No.710954)

Transfer Case Output Shaft Seal

from

$12.79
National has built a reputation as one of the most respected names in the industry. We have offered premium sealing solutions for more than 75 years. Our design team keeps pace with the industry and provides advanced solutions for today’s vehicles.

Product Features:
  • Design type: spring loaded; multi-lip
  • Temperature range: -20 Deg. F to 300 Deg. F / -29 Deg. C to 49 Deg. C
  • Resistance to EP lubricants
  • Low swell in hydrocarbon fluids
  • Delivers quality and reliable performance for every type of repair
See More

In-Demand Spindles for 2010 Lexus RX450hs

Select from 1 premium Spindles parts for your 2010 Lexus RX450h.

Dorman – Spindle Nut M22-1.50 Hex Star Pattern (sold by each) (Part No.615-224)

Spindle Nut M22-1.50 Hex Star Pattern (sold by each)

from

$10.99
This spindle nut is designed to match the fit and function of the original part on specified vehicles. Made of quality materials, it is engineered for reliable performance.

Product Features:
  • Direct replacement – this spindle nut matches the fit and function of the factory part on specified years, makes and models
  • Ideal solution – this nut is a reliable replacement for an original part that is missing or has failed due to fatigue
  • Durable construction – this part is made from quality materials to ensure reliable performance and long service life
  • Trustworthy quality – backed by team of product experts in the United States and more than a century of automotive experience
See More

FAQs for 2010 Lexus RX450h Drivetrains

Which Drivetrains are best-sellers for 2010 Lexus RX450hs?

Out of 10 Drivetrains that fit 2010 Lexus RX450hs, the following parts are the top sellers:

What’s the price range for 2010 Lexus RX450h Drivetrains?

Drivetrain prices for the 2010 Lexus RX450h start at $10.99 and go up to $119.99 for the most premium parts.

What’s the average price of a Drivetrain for a 2010 Lexus RX450h?

The average price for Drivetrains for the 2010 Lexus RX450h is $48.02. Keep in mind the variety of part types within our Drivetrain category so you are likely to find a wide range of prices across a variety of parts and components.

Does Advance Auto Parts sell Drivetrains for other Lexus RX450h model years?

Yes, we currently carry Drivetrains for 11 model years of Lexus RX450hs between 2011 and 2022. Drivetrains are bought most frequently for the following model years: 2022, 2021, 2020, 2019, 2018, 2017, 2016, 2015, and 2014.

What are the cheapest Drivetrains for my 2010 Lexus RX450h?

The cheapest 2010 Lexus RX450h Drivetrains we carry in stock are:

What types of Drivetrains do you sell for my 2010 Lexus RX450h?

As of 11/2/25, these are some of the most in-demand types of Drivetrains for a 2010 Lexus RX450h:

Can I get help with 2010 Lexus RX450h Drivetrain orders?

Contact our customer support team, by chat or phone, through the help desk page, where you can find instant answers about Lexus Drivetrains and more.

What is your return policy for Lexus RX450h Drivetrains?

Advance Auto Parts keeps returns simple. For new Lexus RX450h Drivetrains and accessories, your online orders can be returned, in their original condition, within 45 days. For requirements, see the returns page.