2010 Lexus RX350 Differentials

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Keep Your 2010 Lexus RX350 in Top Shape with Quality Differentials

Whether you’re repairing or upgrading your Differential, using high-quality parts is key to keeping your 2010 Lexus RX350 looking sharp and performing at its best. At Advance Auto Parts we carry a wide selection of dependable options, including Front Differential Pinion Bearings, Differential Pinion Pilot Bearings, and Differential Oil. Whether you’re replacing a damaged part or enhancing your truck’s style and protection, you’ll find exactly what you need to get the job done right.

Explore Related Parts

While you’re upgrading or replacing your Differential, don’t forget to check out other key components like Drive Shafts and Axles and Hubs and Hub Assemblies. At Advance Auto Parts, we’re here to help you keep your 2010 Lexus RX350 in peak condition, inside and out.

Essential 2010 Lexus RX350 Differentials

Valvoline – Valvoline Extended Protection Full Synthetic Automatic Transmission Fluid ATF 1 QT, 904976 (Part No.904976)

Valvoline Extended Protection Full Synthetic Automatic Transmission Fluid ATF 1 QT, 904976

from

$15.99
Modern transmissions are better than ever, with more gears to help improve fuel efficiency and acceleration. Greater performance calls for greater protection. Valvoline Extended Protection Full Synthetic ATF features our exclusive Dual Defense Additive Technology for two layers of protection against metal-on-metal contact and thermal breakdown, all while minimizing wear on clutch components. In fact, Valvoline Extended Protection Full Synthetic ATF is 45% stronger against breakdown compared to major brand DEX/MERC oxidative PDSC performance. Proven to maximize transmission life, our patented formula keeps your modern vehicle shifting smoothly, mile after mile, with the ultimate protection you can only expect from Valvoline, the #1 ATF brand.
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Valvoline – Valvoline Multi-Vehicle (ATF) Full Synthetic Automatic Transmission Fluid 1 GA, 904891 (Part No.904891)

Valvoline Multi-Vehicle (ATF) Full Synthetic Automatic Transmission Fluid 1 GA, 904891

from

$35.99
Choosing an automatic transmission fluid just got easier. Valvoline Full Synthetic MaxLife Multi-Vehicle ATF, the #1 ATF product, is suitable for use in 95% of ATF vehicles in operation with US registered light duty applications. And now, it€™s also recommended for most belt and chain-driven continuously variable transmissions (CVT). Featuring advanced additives to prevent the major causes of transmission breakdown, it€™s designed to help prevent leaks, reduce wear and tear, and maximize performance €“ all for much longer than conventional fluids. It has improved thermal stability for longer fluid life, better viscosity stability for consistent transmission operation, and frictional enhancements for smooth gear engagements. Whether your vehicle has a CVT or traditional automatic, Valvoline MaxLife Multi-Vehicle ATF is suitable for a broad range of transmissions including Ford, GM, Toyota, Honda, Nissan, Hyundai, Subaru, BMW, Mercedes, Volvo, VW and Audi vehicles. It€™s specifically recommended for use in the following applications: GM DEXRON-II, DEXRON-III, DEXRON-VI, and DEX-CVT; Ford MERCON LV; Toyota/Lexus Type T, T-II, T-IV, WS, CVTF FE, and CVTF TC. For the many miles ahead, trust your transmission with Valvoline, the #1 automatic transmission fluid brand.
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National – National Tapered Roller Bearing Cone, HM88649 (Part No.HM88649)

National Tapered Roller Bearing Cone, HM88649

from

$20.79
Manufactured with premium-grade steel, National taper bearing cones feature crowned raceways and rollers to ensure even load distribution.
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Driveworks – Driveworks Taper Bearing Cone, S-HM-88649 (Part No.S-HM-88649)

Driveworks Taper Bearing Cone, S-HM-88649

from

$19.49
Value-priced bearing meets all cataloged application requirements.
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National – National Differential Pinion Seal, 711098 (Part No.711098)

National Differential Pinion Seal, 711098

from

$12.99
National has built a reputation as one of the most respected names in the industry. We have offered premium sealing solutions for more than 75 years. Our design team keeps pace with the industry and provides advanced solutions for today’s vehicles.
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National – National Shaft Repair Sleeve, 99166 (Part No.99166)

National Shaft Repair Sleeve, 99166

from

$36.49
National has built a reputation as one of the most respected names in the industry. We have offered premium sealing solutions for more than 75 years. Our design team keeps pace with the industry and provides advanced solutions for today’s vehicles.
See More

National – National Shaft Repair Sleeve, 99215 (Part No.99215)

National Shaft Repair Sleeve, 99215

from

$48.99
National has built a reputation as one of the most respected names in the industry. We have offered premium sealing solutions for more than 75 years. Our design team keeps pace with the industry and provides advanced solutions for today’s vehicles.
See More

National – National Shaft Repair Sleeve, 99210 (Part No.99210)

National Shaft Repair Sleeve, 99210

from

$49.49
National has built a reputation as one of the most respected names in the industry. We have offered premium sealing solutions for more than 75 years. Our design team keeps pace with the industry and provides advanced solutions for today’s vehicles.
See More

Most Popular Front Differential Pinion Bearing for 2010 Lexus RX350s

Enhance your 2010 Lexus RX350 with this popular Front Differential Pinion Bearing we have in stock, for $19.49.

Driveworks – Driveworks Taper Bearing Cone, S-HM-88649 (Part No.S-HM-88649)

Driveworks Taper Bearing Cone, S-HM-88649

from

$19.49
Value-priced bearing meets all cataloged application requirements.
See More

Best-Selling 2010 Lexus RX350 Differential Pinion Pilot Bearings

Upgrade your RX350 with one of our 3 best-selling Differential Pinion Pilot Bearings.

National – National Shaft Repair Sleeve, 99166 (Part No.99166)

National Shaft Repair Sleeve, 99166

from

$36.49
National has built a reputation as one of the most respected names in the industry. We have offered premium sealing solutions for more than 75 years. Our design team keeps pace with the industry and provides advanced solutions for today’s vehicles.
See More

National – National Shaft Repair Sleeve, 99210 (Part No.99210)

National Shaft Repair Sleeve, 99210

from

$49.49
National has built a reputation as one of the most respected names in the industry. We have offered premium sealing solutions for more than 75 years. Our design team keeps pace with the industry and provides advanced solutions for today’s vehicles.
See More

National – National Shaft Repair Sleeve, 99215 (Part No.99215)

National Shaft Repair Sleeve, 99215

from

$48.99
National has built a reputation as one of the most respected names in the industry. We have offered premium sealing solutions for more than 75 years. Our design team keeps pace with the industry and provides advanced solutions for today’s vehicles.
See More

Top-Quality Differential Oil for 2010 Lexus RX350s

Choose a high-quality OEM or aftermarket Differential Oil for Lexus RX350s and enjoy top-notch performance from $15.99.

Valvoline – Valvoline Multi-Vehicle (ATF) Full Synthetic Automatic Transmission Fluid 1 GA, 904891 (Part No.904891)

Valvoline Multi-Vehicle (ATF) Full Synthetic Automatic Transmission Fluid 1 GA, 904891

from

$35.99
Choosing an automatic transmission fluid just got easier. Valvoline Full Synthetic MaxLife Multi-Vehicle ATF, the #1 ATF product, is suitable for use in 95% of ATF vehicles in operation with US registered light duty applications. And now, it€™s also recommended for most belt and chain-driven continuously variable transmissions (CVT). Featuring advanced additives to prevent the major causes of transmission breakdown, it€™s designed to help prevent leaks, reduce wear and tear, and maximize performance €“ all for much longer than conventional fluids. It has improved thermal stability for longer fluid life, better viscosity stability for consistent transmission operation, and frictional enhancements for smooth gear engagements. Whether your vehicle has a CVT or traditional automatic, Valvoline MaxLife Multi-Vehicle ATF is suitable for a broad range of transmissions including Ford, GM, Toyota, Honda, Nissan, Hyundai, Subaru, BMW, Mercedes, Volvo, VW and Audi vehicles. It€™s specifically recommended for use in the following applications: GM DEXRON-II, DEXRON-III, DEXRON-VI, and DEX-CVT; Ford MERCON LV; Toyota/Lexus Type T, T-II, T-IV, WS, CVTF FE, and CVTF TC. For the many miles ahead, trust your transmission with Valvoline, the #1 automatic transmission fluid brand.
See More

Valvoline – Valvoline Extended Protection Full Synthetic Automatic Transmission Fluid ATF 1 QT, 904976 (Part No.904976)

Valvoline Extended Protection Full Synthetic Automatic Transmission Fluid ATF 1 QT, 904976

from

$15.99
Modern transmissions are better than ever, with more gears to help improve fuel efficiency and acceleration. Greater performance calls for greater protection. Valvoline Extended Protection Full Synthetic ATF features our exclusive Dual Defense Additive Technology for two layers of protection against metal-on-metal contact and thermal breakdown, all while minimizing wear on clutch components. In fact, Valvoline Extended Protection Full Synthetic ATF is 45% stronger against breakdown compared to major brand DEX/MERC oxidative PDSC performance. Proven to maximize transmission life, our patented formula keeps your modern vehicle shifting smoothly, mile after mile, with the ultimate protection you can only expect from Valvoline, the #1 ATF brand.
See More

Our Top Pick for a 2010 Lexus RX350 Differential Pinion Seal

Invest in a durable Differential Pinion Seal for your 2010 Lexus, knowing you’re getting trusted brands and expert craftsmanship.

National – National Differential Pinion Seal, 711098 (Part No.711098)

National Differential Pinion Seal, 711098

from

$12.99
National has built a reputation as one of the most respected names in the industry. We have offered premium sealing solutions for more than 75 years. Our design team keeps pace with the industry and provides advanced solutions for today’s vehicles.
See More

FAQs for 2010 Lexus RX350 Differentials

What are the best-selling Differentials for 2010 Lexus RX350s?

Out of 7 Differentials that fit 2010 Lexus RX350s, the following parts are the top sellers:

What’s the price range for 2010 Lexus RX350 Differentials?

The prices of Differentials for the 2010 Lexus RX350 range from $12.99 up to $49.49 for the most premium parts.

What is the average price of a Differential for a 2010 Lexus RX350?

The average price for Differentials for the 2010 Lexus RX350 is $31.35. Keep in mind the variety of part types within our Differential category, where you are likely to find a wide range of prices across a variety of parts and components.

Does Advance Auto Parts sell Differentials for other Lexus RX350 model years?

Yes, we carry Differentials for 18 model years of Lexus RX350s between 2007 and 2026. The following model years are the most popular for Differential purchases: 2022, 2021, 2020, 2019, 2018, 2017, 2016, 2015, and 2014.

What are the cheapest Differentials for my 2010 Lexus RX350?

Does Advance Auto Parts sell Differentials for any other 2010 Lexus models?

Yes. We stock Differentials for 12 other popular 2010 Lexus models. Some of the most popular are 2010 ES350 Differentials, 2010 GX460 Differentials, 2010 SC430 Differentials, 2010 IS250 Differentials, and 2010 IS350 Differentials.

What types of Differentials do you sell for my 2010 Lexus RX350?

As of 8/2/26, these are some of the most in-demand types of Differentials for a 2010 Lexus RX350:

Can I get help with 2010 Lexus RX350 Differential orders?

Contact our customer support team by chat or phone, through the help desk page, where you can find instant answers about Lexus Differentials and more.

What is your return policy for Lexus RX350 Differentials?

Advance Auto Parts keeps returns simple. For new Lexus RX350 Differentials and accessories, your online orders can be returned, in their original condition, within 45 days. For requirements, see the returns page.