2010 Ford E-350 Super Duty Thermostats

Your 2010 Ford E-350 Super Duty might be the best vehicle you’ve ever owned. Or you may just be struggling to keep it highway-approved. No matter the situation, Advance Auto Parts has the Thermostats you desperately need.

We currently carry 13 Thermostats to choose from for your 2010 Ford E-350 Super Duty, and our inventory prices range from as little as $6.99 up to $48.65.

On top of low prices, Advance Auto Parts offers 4 different trusted brands of Thermostats for the 2010 Ford E-350 Super Duty. We only sell parts from trusted brands like Carquest Premium so that you can find quality parts you can count on.

Don’t take our word for it – check out customer ratings and reviews to buy with confidence. We have 1,281 reviews on our Thermostats for the 2010 Ford E-350 Super Duty from previous customers.

Have parts delivered straight to your home, or find the nearest Advance Auto Parts store to check out our Thermostats stock in-person!

Thermostats for Your 2010 Ford E-350 Super Duty

Carquest Premium – Standard Thermostat: 195 Degrees (Part No.13779)

Standard Thermostat: 195 Degrees

from

$15.79
Carquest Premium Thermostats are manufactured with OEM quality materials and safety standards by an OE Supplier. This thermostat will meet and exceed the expectations of the OE thermostat to insure the best product for your cooling system. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant. Offset design, air relief valve, and OEM style seals included where applicable.

Product Features:
  • High grade stainless steel and copper construction
  • Meets or exceeds OEM standards
  • Consistent and precise response to cooling system needs
  • Original equipment design for worry-free direct fit replacement
  • 100% tested and calibrated
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Carquest Premium – High Flow Thermostat: 170 Degrees (Part No.13967)

High Flow Thermostat: 170 Degrees

from

$14.29
Carquest Premium Thermostats are manufactured with OEM quality materials and safety standards by an OE Supplier. This thermostat will meet and exceed the expectations of the OE thermostat to insure the best product for your cooling system. With the enlarged Orpheus opening, this high flowing thermostat will allow for more gallons per second to flow. This will allow for the engine to cool down at a faster rate compared to the OE to allow for quick and precise cooling for your engine. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant. Offset design, air relief valve, and OEM style seals included where applicable.

Product Features:
  • Larger opening for increased coolant flow
  • Increased strength and durability
  • High grade stainless steel and copper construction
  • Meets or exceeds OEM standards
  • Consistent and precise response to cooling system needs
  • 100% tested and calibrated
See More

Carquest Premium – Standard Thermostat: 180 Degrees (Part No.13778)

Standard Thermostat: 180 Degrees

from

$15.79
Carquest Premium Thermostats are manufactured with OEM quality materials and safety standards by an OE Supplier. This thermostat will meet and exceed the expectations of the OE thermostat to insure the best product for your cooling system. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant. Offset design, air relief valve, and OEM style seals included where applicable.

Product Features:
  • High grade stainless steel and copper construction
  • Meets or exceeds OEM standards
  • Consistent and precise response to cooling system needs
  • Original equipment design for worry-free direct fit replacement
  • 100% tested and calibrated
See More

Motorad UltraStats – Thermostat: 180 Degrees (Part No.5228-180JV)

Thermostat: 180 Degrees

from

$18.29
This premium upgraded thermostat is everything you were looking for. UltraStat Thermostats are the toughest thermostats on the market. All heavy gauge stainless steel construction provides long-life durability, as well as complete corrosion resistance. Exclusive BLVT Valve technology minimizes thermal shock to cooling system components. This is the perfect upgrade to help insure your cooling system is working exactly as you need and expect it to for longevity.

Product Features:
  • Heavy gauge stainless steel components offer increased reliability and long-lasting durability
  • Exclusive BLVT Valve Technology minimizes thermal shock to cooling system components
  • Stainless steel thermal element for unmatched corrosion resistance and revolutionary REAX wax mixture provides quicker reaction time
  • AccuSpring Design for stable temperature control and increased cabin comfort
See More

Carquest Premium – High Flow Thermostat: 180 Degrees (Part No.13968)

High Flow Thermostat: 180 Degrees

from

$12.49
Carquest Premium Thermostats are manufactured with OEM quality materials and safety standards by an OE Supplier. This thermostat will meet and exceed the expectations of the OE thermostat to insure the best product for your cooling system. With the enlarged Orpheus opening, this high flowing thermostat will allow for more gallons per second to flow. This will allow for the engine to cool down at a faster rate compared to the OE to allow for quick and precise cooling for your engine. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant. Offset design, air relief valve, and OEM style seals included where applicable.

Product Features:
  • Larger opening for increased coolant flow
  • Increased strength and durability
  • High grade stainless steel and copper construction
  • Meets or exceeds OEM standards
  • Consistent and precise response to cooling system needs
  • 100% tested and calibrated
See More

Carquest Premium – Standard Thermostat: 195 Degrees (Part No.14989)

Standard Thermostat: 195 Degrees

from

$15.79
Carquest Premium Thermostats are manufactured with OEM quality materials and safety standards by an OE Supplier. This thermostat will meet and exceed the expectations of the OE thermostat to insure the best product for your cooling system. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant. Offset design, air relief valve, and OEM style seals included where applicable.

Product Features:
  • High grade stainless steel and copper construction
  • Meets or exceeds OEM standards
  • Consistent and precise response to cooling system needs
  • Original equipment design for worry-free direct fit replacement
  • 100% tested and calibrated
See More

Carquest Premium Stats – High Flow Thermostat: 180 Degrees (Part No.45778)

High Flow Thermostat: 180 Degrees

from

$15.79
Manufactured with OEM quality materials and safety standards by an OE Supplier. This thermostat will meet and exceed the expectations of the OE thermostat to insure the best product for your cooling system. With the enlarged Orpheus opening, this high flowing thermostat will allow for more gallons per second to flow. This will allow for the engine to cool down at a faster rate compared to the OE to allow for quick and precise cooling for your engine. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant. Offset design, air relief valve, and OEM style seals included where applicable.

Product Features:
  • High grade stainless steel and copper construction
  • Meets or exceeds OEM standards
  • Consistent and precise response to cooling system needs
  • Original equipment design for worry-free direct fit replacement
  • 100% tested and calibrated
See More

Motorad UltraStats – Thermostat: 195 Degrees (Part No.5228-195JV)

Thermostat: 195 Degrees

from

$18.29
This premium upgraded thermostat is everything you were looking for. UltraStat Thermostats are the toughest thermostats on the market. All heavy gauge stainless steel construction provides long-life durability, as well as complete corrosion resistance. Exclusive BLVT Valve technology minimizes thermal shock to cooling system components. This is the perfect upgrade to help insure your cooling system is working exactly as you need and expect it to for longevity.

Product Features:
  • Heavy gauge stainless steel components offer increased reliability and long-lasting durability
  • Exclusive BLVT Valve Technology minimizes thermal shock to cooling system components
  • Stainless steel thermal element for unmatched corrosion resistance and revolutionary REAX wax mixture provides quicker reaction time
  • AccuSpring Design for stable temperature control and increased cabin comfort
See More

Motorcraft – Thermostat (Part No.G4000212055MTR)

Thermostat

from

$48.65
The Motorcraft Thermostat is a direct fit OEM replacement that guarantees the same performance and quality provided by the vehicle manufacturer.

Product Features:
  • Heavy-duty quality for long life
  • Stainless steel or brass bridge and spring frame, channel-constructed for strength and rigidity
  • Stainless steel, tapered-end pistons with flexible elastomeric boots
  • Streamlined venturi nozzle for maximum coolant flow
  • Brass cover and guide for heat motor piston
  • Mounting flange designed to properly fit and seat the thermostat in the housing
  • Stainless steel spring offers precise operating compression
  • Heat motor in high-strength brass housing
  • Rulon seal for heat motor piston
  • Specially formulated expansive wax compound
See More

Motorcraft – Motorcraft Thermostat (Part No.G4000349158MTR)

Motorcraft Thermostat

from

$19.78
The Motorcraft Thermostat is a direct fit OEM replacement that guarantees the same performance and quality provided by the vehicle manufacturer.

Product Features:
  • Heavy-duty quality for long life
  • Stainless steel or brass bridge and spring frame, channel-constructed for strength and rigidity
  • Stainless steel, tapered-end pistons with flexible elastomeric boots
  • Streamlined venturi nozzle for maximum coolant flow
  • Brass cover and guide for heat motor piston
  • Mounting flange designed to properly fit and seat the thermostat in the housing
  • Stainless steel spring offers precise operating compression
  • Heat motor in high-strength brass housing
  • Rulon seal for heat motor piston
  • Specially formulated expansive wax compound
See More

Motorcraft – ORIGINAL EQUIPMENT THERMOSTAT (Part No.RT-1169)

ORIGINAL EQUIPMENT THERMOSTAT

from

$45.99
ORIGINAL EQUIPMENT THERMOSTAT

Motorcraft – ENG COOLANT THRMSTAT (Part No.RT-1195)

ENG COOLANT THRMSTAT

from

$20.99
ENG COOLANT THRMSTAT

Carquest Premium – Thermostat (Part No.48447)

Thermostat

from

$6.99
Original equipment design provides exact fit and performance.

Product Features:
  • Precise fitting sealing edges prevent leakage and premature cooling.
  • Self-cleaning and self-aligning thermostat valve.
  • Stainless steel assembly and springs are engineered for long life and smooth performance.
See More

FAQs for 2010 Ford E-350 Super Duty Thermostats

What are the most popular Thermostats for the 2010 Ford E-350 Super Duty?

With 4 brands you can trust, our most popular Thermostats for the 2010 Ford E-350 Super Duty parts are:
Standard Thermostat: 195 Degrees
from $15.79
(56)
Standard Thermostat: 195 Degrees
Thermostats
High Flow Thermostat: 170 Degrees
from $14.29
(16)
High Flow Thermostat: 170 Degrees
Thermostats
Thermostat: 195 Degrees
from $18.29
This product is not rated
Thermostat: 195 Degrees
Thermostats

What are the best aftermarket Thermostats for the 2010 Ford E-350 Super Duty?

See what past customers had to say about our highest-rated Thermostats for the 2010 Ford E-350 Super Duty:
High Flow Thermostat: 180 Degrees
from $15.79
(6)
High Flow Thermostat: 180 Degrees
“good quality”
High Flow Thermostat: 180 Degrees
from $12.49
(2)
High Flow Thermostat: 180 Degrees
“It fit my 94 town car and works affordable”