2006 Mercedes-Benz E350 Drivetrains

Please Select your Vehicle to See Exact Fit Parts

Essential Drivetrains for 2006 Mercedes-Benz E350s

Driveworks – Tapered Roller Bearing (Part No.S-32010X)

Tapered Roller Bearing

from

$28.99
Product Features:
  • Brand may vary by location
See More

National – Multi-Purpose Bearing (Part No.A-18)

Multi-Purpose Bearing

from

$17.99
Product Features:
  • CONSISTENT PERFORMANCE: Matched cup and cone components ensure consistent performance
  • PREMIUM MATERIALS: Precision manufactured using premium-grade steel for outstanding durability and performance
  • SMOOTH ROTATION: Crowned raceways and rollers for even load distribution
  • OE-STYLE DESIGN: Engineered to meet OE specifications
  • COMPREHENSIVE COVERAGE: Industry-leading coverage for domestic and import applications
  • RIGOROUS TESTING: Comprehensive testing throughout design and development processes by National engineers for quality you can count on
See More

Dorman – Driveshaft Flex Coupler (Part No.935-511)

Driveshaft Flex Coupler

from

$333.99
This drive shaft coupler is designed to match the fit and function of the original coupler on specified vehicles, and is engineered for durability and reliable performance.

Product Features:
  • Direct replacement – this drive shaft coupler is designed to match the fit and function of the original coupler on specified vehicles
  • Restores functionality – reliable replacement for an original coupler that has failed due to wear or damaged due to collision
  • Durable construction – this part is made from quality materials to ensure reliable performance and long service life
  • Trustworthy quality – backed by team of product experts in the United States and more than a century of automotive experience
See More

Dorman – Driveshaft Flex Coupler (Part No.935-910)

Driveshaft Flex Coupler

from

$168.99
This drive shaft coupler is designed to match the fit and function of the original coupler on specified vehicles, and is engineered for durability and reliable performance.

Product Features:
  • Direct replacement – this drive shaft coupler is designed to match the fit and function of the original coupler on specified vehicles
  • Restores functionality – reliable replacement for an original coupler that has failed due to wear or damaged due to collision
  • Durable construction – this part is made from quality materials to ensure reliable performance and long service life
  • Trustworthy quality – backed by team of product experts in the United States and more than a century of automotive experience
See More

National – Multi-Purpose Bearing (Part No.A-5)

Multi-Purpose Bearing

from

$17.99
Product Features:
  • CONSISTENT PERFORMANCE: Matched cup and cone components ensure consistent performance
  • PREMIUM MATERIALS: Precision manufactured using premium-grade steel for outstanding durability and performance
  • SMOOTH ROTATION: Crowned raceways and rollers for even load distribution
  • OE-STYLE DESIGN: Engineered to meet OE specifications
  • COMPREHENSIVE COVERAGE: Industry-leading coverage for domestic and import applications
  • RIGOROUS TESTING: Comprehensive testing throughout design and development processes by National engineers for quality you can count on
See More

Dorman – Drive Shaft Repair Kit – Only Fits Dorman Driveshafts (Part No.932-985)

Drive Shaft Repair Kit - Only Fits Dorman Driveshafts

from

$57.99
This drive shaft repair kit is designed to match the original hardware required to repair the drive shaft on specified vehicles. Made of quality components, this kit is engineered for reliable performance and durability.

Product Features:
  • Direct replacement – this drive shaft repair kit is designed to match the original hardware required to repair the drive shaft on specified vehicle
  • Ideal solution – this kit is a reliable replacement for original components that have failed due to fatigue
  • Durable construction – this kit is made from quality components to ensure reliable performance and a long service life
  • Trustworthy quality – backed by team of product experts in the United States and more than a century of automotive experience
See More

National – Multi-Purpose Seal (Part No.710678)

Multi-Purpose Seal

from

$14.99
National has built a reputation as one of the most respected names in the industry. We have offered premium sealing solutions for more than 75 years. Our design team keeps pace with the industry and provides advanced solutions for today’s vehicles.

Product Features:
  • Design type: spring loaded; multi-lip
  • Temperature range: -30 Deg. F to 325 Deg. F / -34 Deg. C to 163 Deg. C
  • Superior thermal and chemical resistance
  • Good abrasion and dry running capability
  • Delivers quality and reliable performance for every type of repair
See More

National – Axle Shaft Seal (Part No.711049)

Axle Shaft Seal

from

$24.49
National has built a reputation as one of the most respected names in the industry. We have offered premium sealing solutions for more than 75 years. Our design team keeps pace with the industry and provides advanced solutions for today’s vehicles.

Product Features:
  • Design type: spring loaded; multi-lip
  • Temperature range: -40 Deg. F to 400 Deg. F / -40 Deg. C to 204 Deg. C
  • Excellent high temperature capabilities
  • Compatible with wide range of fluids
  • Delivers quality and reliable performance for every type of repair
See More

Rein – Driveshaft Boot (Part No.BKD0066R)

Driveshaft Boot

from

$6.99
Boot kits protect a joint in the car that would be destroyed by dirt, sand and other particles if left exposed, even under normal conditions so it’s important that they be properly maintained and in good condition. Rein Automotive provides application specific driveshaft boot kits that come guaranteed to fit the first time.
See More

Driveworks – Taper Bearing Set (Part No.S-A-5)

Taper Bearing Set

from

$9.99
Value-priced bearing meets all cataloged application requirements.

Product Features:
  • Brand may vary by location
See More

National – Shaft Repair Sleeve (Part No.99139)

Shaft Repair Sleeve

from

$39.99
National® has built a reputation as one of the most respected names in the industry. We have offered premium sealing solutions for more than 75 years. Our design team keeps pace with the industry and provides advanced solutions for today’s vehicles.

Product Features:
  • Designed to repair damaged, grooved or worn shafts
  • Durable stainless steel construction for corrosion-free sealing surface that surpasses most original shaft specifications
  • Ideal for a shaft where indications of seal wear, such as tracks or grooves have developed
  • Ultra-thin construction (0.01/0.25mm wall thickness) allows original seal size to be used with minimal additional lip loading
  • Easy to install with removable flange and installation tool
  • Installation tool reduces sleeve distortion and allows for installation without removal from the shaft
See More

National – Shaft Repair Sleeve (Part No.99177)

Shaft Repair Sleeve

from

$39.99
National has built a reputation as one of the most respected names in the industry. We have offered premium sealing solutions for more than 75 years. Our design team keeps pace with the industry and provides advanced solutions for today’s vehicles.

Product Features:
  • Designed to repair damaged, grooved or worn shafts
  • Durable stainless steel construction for corrosion-free sealing surface that surpasses most original shaft specifications
  • Ideal for a shaft where indications of seal wear, such as tracks or grooves have developed
  • Ultra-thin construction (0.01/0.25mm wall thickness) allows original seal size to be used with minimal additional lip loading
  • Easy to install with removable flange and installation tool
See More

Driveworks – Camshaft Seal (Part No.S-99139)

Camshaft Seal

from

$23.99
Product Features:
  • Brand may vary by location
See More

National – Multi-Purpose Bearing (Part No.106-CC)

Multi-Purpose Bearing

from

$23.99
National Oil Seals & Bearings offer a full line of premium oil seals and bearings.

Product Features:
  • BUILT TO LAST — Advanced heat treatment process for strength
  • PREMIUM MATERIALS — Precision manufactured using premium-grade steel for lasting performance and extended bearing life
  • RELIABLE PERFORMANCE — Element size and quantity are engineered to meet or exceed the load rating of OE bearings
  • COMPREHENSIVE COVERAGE — Industry-leading coverage for domestic and import applications
  • RIGOROUS TESTING — Comprehensive testing throughout design and development processes by National engineers for quality you can count on
See More

Rein – Drive Shaft Support Bearing (Part No.BEM0039P)

Drive Shaft Support Bearing

from

$15.99
Drive Shaft Support Bearing

National – Bearing Race (Part No.M86610)

Bearing Race

from

$9.99
Manufactured with premium-grade steel, National taper bearing cups feature crowned raceways to ensure even load distribution.

Product Features:
  • PREMIUM MATERIALS – Precision manufactured using premium-grade steel for outstanding durability and performance
  • SMOOTH ROTATION – Crowned raceways for even load distribution
  • OE-STYLE DESIGN – Engineered to meet OE specifications
  • COMPREHENSIVE COVERAGE – Industry-leading coverage for domestic and import applications
  • RIGOROUS TESTING – Comprehensive testing throughout design and development processes by National engineers for quality you can count on
See More

Dorman – Spindle Nut M26-1.50 – Hex Size 32mm (sold by each) (Part No.615-261)

Spindle Nut M26-1.50 - Hex Size 32mm (sold by each)

from

$78.99
Spindle Nut M26-1.50 – Hex Size 32mm (sold by each)

Dorman – Drive Shaft: Greaseable, Adjustable (Part No.976-181)

Drive Shaft: Greaseable, Adjustable

from

$1080.99
Replacing a drive shaft doesn’t have to be complicated. This complete drive shaft assembly is pre-balanced and ready to install with 100% new yokes, tubes, constant velocity (CV) joints and universal joints.

Product Features:
  • Direct replacement – this drive shaft is made to the original equipment dimensions for dependable fit and performance
  • 100% new – this drive shaft is made from all new components so there’s no core charge or return hassle
  • Ready to install – this drive shaft arrives pre-balanced to make installation quick and simple
  • Serviceable construction – non-staked universal joints are designed for future serviceability
See More

Dorman – Drive Shaft (Part No.986-036)

Drive Shaft

from

$832.99
Replacing a drive shaft doesn’t have to be complicated. This complete drive shaft assembly is pre-balanced and ready to install with 100% new yokes, tubes, constant velocity (CV) joints and universal joints.

Product Features:
  • Direct replacement – this drive shaft is made to the original equipment dimensions for dependable fit and performance
  • 100% new – this drive shaft is made from all new components so there’s no core charge or return hassle
  • Ready to install – this drive shaft arrives pre-balanced to make installation quick and simple
  • Serviceable construction – non-staked universal joints are designed for future serviceability
See More

Dorman – Drive Shaft: Adjustable (Part No.976-545)

Drive Shaft: Adjustable

from

$946.99
Replacing a drive shaft doesn’t have to be complicated. This complete drive shaft assembly is pre-balanced and ready to install with 100% new yokes, tubes, constant velocity (CV) joints and universal joints.

Product Features:
  • Direct replacement – this drive shaft is made to the original equipment dimensions for dependable fit and performance
  • 100% new – this drive shaft is made from all new components so there’s no core charge or return hassle
  • Ready to install – this drive shaft arrives pre-balanced to make installation quick and simple
  • Serviceable construction – non-staked universal joints are designed for future serviceability
See More

Valvoline – MaxLife Multi-Vehicle Automatic Transmission Fluid, 1 Gallon (Part No.773775)

MaxLife Multi-Vehicle Automatic Transmission Fluid, 1 Gallon

from

$35.99
Valvoline MaxLife Multi-Vehicle ATF is a full-synthetic formulation with advanced additives to prevent the major causes of transmission breakdown and help extend transmission life.  Developed to help prevent leaks, maximize transmission performance, reduce transmission wear, and maintain smooth shifting longer than conventional fluids. It is suitable for use in a broad range of ATF applications including most Ford, GM, Toyota, Honda, Nissan, Hyundai, BMW, Mercedes, Volvo, VW & Audi. Recommended for use in the following applications: GM DEXRON-II, DEXRON-III, DEXRON-VI, Ford MERCON LV, Toyota/Lexus Type T, T-II, T-IV, WS, Honda/Acura, ATF-Z1, Nissan/Infiniti Matic-D, Matic-J, Matric-K, Matic-S, Hyundai/Kia SP-II, SP-III, SP-IV, SPH-IV, BMW 7045E, ETL 8072B, LA2634, LT71141, Allison C-4, Mercedes Benz NAG-1, Volvo 1161521, 1161540, 97340, 1273.41, and VW/Audi G-052-025-A2, G-052-162-A1. For CVT applications Valvoline recommends Valvoline Full Synthetic CVT Fluid.

Product Features:
  • Formulated with full-synthetic base oils and long life friction modifiers to help improve smooth shifting, eliminate slippage and shudder, prevent clutch wear and improve drivability longer than conventional fluids
  • High-performance seal conditioners maintain and preserve the elasticity of seals to help prevent leaks in high mileage transmissions
  • Developed with anti-wear technology to help improve transmission durability
  • Engineered with a proprietary blend of base oils and advanced additives to provide better oil flow at low temperatures and greater film protection at higher temperatures
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Castrol – Transmax ATF/CVT Universal Transmission Fluid, Smooth Performance, 1 Gallon (Part No.15E0C8)

Transmax ATF/CVT Universal Transmission Fluid, Smooth Performance, 1 Gallon

from

$28.99
Castrol® Transmax® ATF/CVT Universal is a premium full-synthetic transmission fluid engineered for exceptional performance in both traditional step-shifting automatic transmissions and modern continuously variable transmissions (CVTs). Featuring Castrol Smooth Drive® Technology, it ensures enhanced friction durability for seamless gear shifts and superior high-temperature protection to resist oxidation. This advanced formulation offers unmatched protection against copper corrosion, extending the life of your transmission system. Its broad compatibility covers a wide range of ATF and CVT applications, including Dexron VI, Mercon LV, Toyota WS, Honda DW-1, Nissan Matic S, and many more, making it ideal for diverse vehicle types, including hybrids. Designed to improve workshop efficiency and simplify inventory management, this fluid is a versatile solution for professional mechanics and DIY enthusiasts alike. Packaged in a convenient 1-gallon size, it delivers outstanding value and reliability for maintaining optimal transmission performance.

Product Features:
  • Enhanced friction durability for smooth transmission performance
  • Superior high temperature protection to effectively resist oxidation
  • Unsurpassed protection against copper corrosion
  • Broad scope of vehicle applications improves workshop efficiency and inventory management
  • ATF Applications: Dexron VI (Dexron III, Dexron), Mercon LV (Mercon SP, Mercon V, Mercon), JASO 1A (03), JASO 1A LV (13), Toyota T IV, Toyota T III, Toyota WS, Honda/Acura DW 1/Z 1, Nissan Matic D, Matic J, Matic S, Hyundai/Kia SP IV, SP III
  • ATF Applications: Mazda ATF M-V, M-III, FZ, Mitsubishi SP IV, SP III, IIM, II, PA, J3, VW/Audi (6, 8 & 9 speed automatics), BMW/Mini (6, 8 and 9 speed automatics), Jaguar/Land Rover (6, 8 & 9 speed automatics), Porsche (6, 8 & 9 speed automatics)
  • ATF Applications: Volvo (6, 8 and 9 speed automatics), Volvo Transmission Oil 97342, AT102, Mercedes-Benz (7 and 9 speed automatics)
  • CVT Applications: Toyota CVT Fluid TC, Toyota CVT Fluid FE , Nissan CVT Fluid NS-1, Nissan CVT Fluid NS-2, Nissan CVT Fluid NS-3, Subaru i-CVT Fluid, Subaru i-CVT FG, Subaru Lineartronic High Torque Chain CVTF, Honda HCF-2
See More

National – Shaft Repair Sleeve (Part No.99157)

Shaft Repair Sleeve

from

$37.99
National® has built a reputation as one of the most respected names in the industry. We have offered premium sealing solutions for more than 75 years. Our design team keeps pace with the industry and provides advanced solutions for today’s vehicles.

Product Features:
  • Designed to repair damaged, grooved or worn shafts
  • Durable stainless steel construction for corrosion-free sealing surface that surpasses most original shaft specifications
  • Ideal for a shaft where indications of seal wear, such as tracks or grooves have developed
  • Ultra-thin construction (0.01/0.25mm wall thickness) allows original seal size to be used with minimal additional lip loading
  • Easy to install with removable flange and installation tool
  • Installation tool reduces sleeve distortion and allows for installation without removal from the shaft
See More

National – Shaft Repair Sleeve (Part No.99189)

Shaft Repair Sleeve

from

$38.99
National has built a reputation as one of the most respected names in the industry. We have offered premium sealing solutions for more than 75 years. Our design team keeps pace with the industry and provides advanced solutions for today’s vehicles.

Product Features:
  • Designed to repair damaged, grooved or worn shafts
  • Durable stainless steel construction for corrosion-free sealing surface that surpasses most original shaft specifications
  • Ideal for a shaft where indications of seal wear, such as tracks or grooves have developed
  • Ultra-thin construction (0.01/0.25mm wall thickness) allows original seal size to be used with minimal additional lip loading
  • Easy to install with removable flange and installation tool
See More

Upgrade your 2006 Mercedes-Benz E350 with Top-Quality Drivetrains

When it comes to maintaining or upgrading your 2006 Mercedes-Benz E350, nothing is more important than using high-quality OEM or aftermarket parts that you can trust. Whether you’re repairing damage to your Mercedes-Benz or enhancing its overall performance, Drivetrains are key to keeping your E350 functioning at its best. At Advance Auto Parts, we offer a wide selection of 23 Drivetrains for the 2006 Mercedes-Benz E350, designed to meet your needs without breaking the bank. From Spindle replacements to Transfer Cases upgrades, we’ve got you covered with parts that fit your vehicle perfectly and ensure long-lasting performance.

Affordable Prices and Wide Selection

Shopping for Drivetrains for any vehicle can be a hassle, especially if you’re on a budget. But with Advance Auto Parts, you can find high-quality Drivetrains for your 2006 Mercedes-Benz E350 at great prices. Our Drivetrains inventory for this model ranges from just $6.99 to $1,080.99, with an average price of $105.72. Our 23 Drivetrains in stock come from 5 trusted brands, so you’re sure to find the right part for your 2006 Mercedes-Benz E350 without overspending.

Top Brands and High Customer Satisfaction

Advance Auto Parts takes pride in offering only the best brands in the automotive industry. For your 2006 Mercedes-Benz E350, we stock popular OEM and aftermarket Drivetrains from top names like Valvoline, National, Driveworks, and more. Valvoline Drivetrains start at just $35.99 and boast an impressive 4.8 stars average rating from customers. National and Driveworks also bring quality to the table, with Drivetrains available starting at $9.99, and at an average 4.3 stars rating. With 1,111 customer reviews and counting, our 2006 Mercedes-Benz E350 Drivetrains have a strong track record of reliability, ensuring you can trust your purchase.

Explore Related Parts and More

While you’re here, don’t forget to check out other essential categories that go hand in hand with Drivetrain upgrades. Explore related part types like Batteries and Chargers, Oil and Lubricants and more to make sure your 2006 Mercedes-Benz E350 is always ready to roll. We’re committed to providing you with everything you need to keep your E350 in top shape, all in one place. Start shopping confidently below for your 2006 Mercedes-Benz E350!

Best-Selling Spindles for 2006 Mercedes-Benz E350s

Enhance the driving experience in your Mercedes-Benz with 1 quality Spindle components, starting at $78.99.

Dorman – Spindle Nut M26-1.50 – Hex Size 32mm (sold by each) (Part No.615-261)

Spindle Nut M26-1.50 - Hex Size 32mm (sold by each)

from

$78.99
Spindle Nut M26-1.50 – Hex Size 32mm (sold by each)

Most Popular 2006 Mercedes-Benz E350 Transfer Cases

Customize your Mercedes-Benz with 4 Transfer Cases products like Transfer Case Output Shaft Seals and Input Shaft Seals, all priced under $38.99.

National – Shaft Repair Sleeve (Part No.99157)

Shaft Repair Sleeve

from

$37.99
National® has built a reputation as one of the most respected names in the industry. We have offered premium sealing solutions for more than 75 years. Our design team keeps pace with the industry and provides advanced solutions for today’s vehicles.

Product Features:
  • Designed to repair damaged, grooved or worn shafts
  • Durable stainless steel construction for corrosion-free sealing surface that surpasses most original shaft specifications
  • Ideal for a shaft where indications of seal wear, such as tracks or grooves have developed
  • Ultra-thin construction (0.01/0.25mm wall thickness) allows original seal size to be used with minimal additional lip loading
  • Easy to install with removable flange and installation tool
  • Installation tool reduces sleeve distortion and allows for installation without removal from the shaft
See More

National – Shaft Repair Sleeve (Part No.99189)

Shaft Repair Sleeve

from

$38.99
National has built a reputation as one of the most respected names in the industry. We have offered premium sealing solutions for more than 75 years. Our design team keeps pace with the industry and provides advanced solutions for today’s vehicles.

Product Features:
  • Designed to repair damaged, grooved or worn shafts
  • Durable stainless steel construction for corrosion-free sealing surface that surpasses most original shaft specifications
  • Ideal for a shaft where indications of seal wear, such as tracks or grooves have developed
  • Ultra-thin construction (0.01/0.25mm wall thickness) allows original seal size to be used with minimal additional lip loading
  • Easy to install with removable flange and installation tool
See More

National – Axle Shaft Seal (Part No.711049)

Axle Shaft Seal

from

$24.49
National has built a reputation as one of the most respected names in the industry. We have offered premium sealing solutions for more than 75 years. Our design team keeps pace with the industry and provides advanced solutions for today’s vehicles.

Product Features:
  • Design type: spring loaded; multi-lip
  • Temperature range: -40 Deg. F to 400 Deg. F / -40 Deg. C to 204 Deg. C
  • Excellent high temperature capabilities
  • Compatible with wide range of fluids
  • Delivers quality and reliable performance for every type of repair
See More

National – Multi-Purpose Seal (Part No.710678)

Multi-Purpose Seal

from

$14.99
National has built a reputation as one of the most respected names in the industry. We have offered premium sealing solutions for more than 75 years. Our design team keeps pace with the industry and provides advanced solutions for today’s vehicles.

Product Features:
  • Design type: spring loaded; multi-lip
  • Temperature range: -30 Deg. F to 325 Deg. F / -34 Deg. C to 163 Deg. C
  • Superior thermal and chemical resistance
  • Good abrasion and dry running capability
  • Delivers quality and reliable performance for every type of repair
See More

Top Picks for 2006 Mercedes-Benz E350 Drive Shafts and Axles

Upgrade Mercedes-Benz E350s with top-quality Drive Shafts and Axles parts, including 11 OEM and aftermarket selections for your 2006 model.

National – Shaft Repair Sleeve (Part No.99139)

Shaft Repair Sleeve

from

$39.99
National® has built a reputation as one of the most respected names in the industry. We have offered premium sealing solutions for more than 75 years. Our design team keeps pace with the industry and provides advanced solutions for today’s vehicles.

Product Features:
  • Designed to repair damaged, grooved or worn shafts
  • Durable stainless steel construction for corrosion-free sealing surface that surpasses most original shaft specifications
  • Ideal for a shaft where indications of seal wear, such as tracks or grooves have developed
  • Ultra-thin construction (0.01/0.25mm wall thickness) allows original seal size to be used with minimal additional lip loading
  • Easy to install with removable flange and installation tool
  • Installation tool reduces sleeve distortion and allows for installation without removal from the shaft
See More

Driveworks – Taper Bearing Set (Part No.S-A-5)

Taper Bearing Set

from

$9.99
Value-priced bearing meets all cataloged application requirements.

Product Features:
  • Brand may vary by location
See More

National – Multi-Purpose Bearing (Part No.A-5)

Multi-Purpose Bearing

from

$17.99
Product Features:
  • CONSISTENT PERFORMANCE: Matched cup and cone components ensure consistent performance
  • PREMIUM MATERIALS: Precision manufactured using premium-grade steel for outstanding durability and performance
  • SMOOTH ROTATION: Crowned raceways and rollers for even load distribution
  • OE-STYLE DESIGN: Engineered to meet OE specifications
  • COMPREHENSIVE COVERAGE: Industry-leading coverage for domestic and import applications
  • RIGOROUS TESTING: Comprehensive testing throughout design and development processes by National engineers for quality you can count on
See More

National – Multi-Purpose Bearing (Part No.106-CC)

Multi-Purpose Bearing

from

$23.99
National Oil Seals & Bearings offer a full line of premium oil seals and bearings.

Product Features:
  • BUILT TO LAST — Advanced heat treatment process for strength
  • PREMIUM MATERIALS — Precision manufactured using premium-grade steel for lasting performance and extended bearing life
  • RELIABLE PERFORMANCE — Element size and quantity are engineered to meet or exceed the load rating of OE bearings
  • COMPREHENSIVE COVERAGE — Industry-leading coverage for domestic and import applications
  • RIGOROUS TESTING — Comprehensive testing throughout design and development processes by National engineers for quality you can count on
See More

Dorman – Drive Shaft Repair Kit – Only Fits Dorman Driveshafts (Part No.932-985)

Drive Shaft Repair Kit - Only Fits Dorman Driveshafts

from

$57.99
This drive shaft repair kit is designed to match the original hardware required to repair the drive shaft on specified vehicles. Made of quality components, this kit is engineered for reliable performance and durability.

Product Features:
  • Direct replacement – this drive shaft repair kit is designed to match the original hardware required to repair the drive shaft on specified vehicle
  • Ideal solution – this kit is a reliable replacement for original components that have failed due to fatigue
  • Durable construction – this kit is made from quality components to ensure reliable performance and a long service life
  • Trustworthy quality – backed by team of product experts in the United States and more than a century of automotive experience
See More

Rein – Drive Shaft Support Bearing (Part No.BEM0039P)

Drive Shaft Support Bearing

from

$15.99
Drive Shaft Support Bearing

Rein – Driveshaft Boot (Part No.BKD0066R)

Driveshaft Boot

from

$6.99
Boot kits protect a joint in the car that would be destroyed by dirt, sand and other particles if left exposed, even under normal conditions so it’s important that they be properly maintained and in good condition. Rein Automotive provides application specific driveshaft boot kits that come guaranteed to fit the first time.
See More

Dorman – Drive Shaft: Greaseable, Adjustable (Part No.976-181)

Drive Shaft: Greaseable, Adjustable

from

$1080.99
Replacing a drive shaft doesn’t have to be complicated. This complete drive shaft assembly is pre-balanced and ready to install with 100% new yokes, tubes, constant velocity (CV) joints and universal joints.

Product Features:
  • Direct replacement – this drive shaft is made to the original equipment dimensions for dependable fit and performance
  • 100% new – this drive shaft is made from all new components so there’s no core charge or return hassle
  • Ready to install – this drive shaft arrives pre-balanced to make installation quick and simple
  • Serviceable construction – non-staked universal joints are designed for future serviceability
See More

Dorman – Drive Shaft: Adjustable (Part No.976-697)

Drive Shaft: Adjustable

from

$837.99
Replacing a drive shaft doesn’t have to be complicated. This complete drive shaft assembly is pre-balanced and ready to install with 100% new yokes, tubes, constant velocity (CV) joints and universal joints.

Product Features:
  • Direct replacement – this drive shaft is made to the original equipment dimensions for dependable fit and performance
  • 100% new – this drive shaft is made from all new components so there’s no core charge or return hassle
  • Ready to install – this drive shaft arrives pre-balanced to make installation quick and simple
  • Serviceable construction – non-staked universal joints are designed for future serviceability
See More

Dorman – One-Piece Steel Driveshaft Assembly (OE Fix) (Part No.936-331)

One-Piece Steel Driveshaft Assembly (OE Fix)

from

$478.99
The original drive shafts on specific vehicles have permanently staked universal joints that make servicing difficult. This Dorman OE FIX front drive shaft makes the U-joints serviceable for simpler maintenance.

Product Features:
  • Ready to install – this drive shaft is shipped pre-assembled and factory balanced to ensure immediate smooth operation
  • All-new manufacturing – made 100% new, not remanufactured, so there’s no core charge or return hassle
  • Quality engineering – designed in the United States and backed by decades of automotive aftermarket experience
  • Simplifies repair – this replacement makes the U-joints serviceable for simpler maintenance
See More

Dorman – Driveshaft Flex Coupler (Part No.935-910)

Driveshaft Flex Coupler

from

$168.99
This drive shaft coupler is designed to match the fit and function of the original coupler on specified vehicles, and is engineered for durability and reliable performance.

Product Features:
  • Direct replacement – this drive shaft coupler is designed to match the fit and function of the original coupler on specified vehicles
  • Restores functionality – reliable replacement for an original coupler that has failed due to wear or damaged due to collision
  • Durable construction – this part is made from quality materials to ensure reliable performance and long service life
  • Trustworthy quality – backed by team of product experts in the United States and more than a century of automotive experience
See More

In-Demand Differentials for 2006 Mercedes-Benz E350s

Select from 7 premium Differentials parts for your 2006 Mercedes-Benz E350, with prices ranging from $9.99 to $39.99.

Valvoline – MaxLife Multi-Vehicle Automatic Transmission Fluid, 1 Gallon (Part No.773775)

MaxLife Multi-Vehicle Automatic Transmission Fluid, 1 Gallon

from

$35.99
Valvoline MaxLife Multi-Vehicle ATF is a full-synthetic formulation with advanced additives to prevent the major causes of transmission breakdown and help extend transmission life.  Developed to help prevent leaks, maximize transmission performance, reduce transmission wear, and maintain smooth shifting longer than conventional fluids. It is suitable for use in a broad range of ATF applications including most Ford, GM, Toyota, Honda, Nissan, Hyundai, BMW, Mercedes, Volvo, VW & Audi. Recommended for use in the following applications: GM DEXRON-II, DEXRON-III, DEXRON-VI, Ford MERCON LV, Toyota/Lexus Type T, T-II, T-IV, WS, Honda/Acura, ATF-Z1, Nissan/Infiniti Matic-D, Matic-J, Matric-K, Matic-S, Hyundai/Kia SP-II, SP-III, SP-IV, SPH-IV, BMW 7045E, ETL 8072B, LA2634, LT71141, Allison C-4, Mercedes Benz NAG-1, Volvo 1161521, 1161540, 97340, 1273.41, and VW/Audi G-052-025-A2, G-052-162-A1. For CVT applications Valvoline recommends Valvoline Full Synthetic CVT Fluid.

Product Features:
  • Formulated with full-synthetic base oils and long life friction modifiers to help improve smooth shifting, eliminate slippage and shudder, prevent clutch wear and improve drivability longer than conventional fluids
  • High-performance seal conditioners maintain and preserve the elasticity of seals to help prevent leaks in high mileage transmissions
  • Developed with anti-wear technology to help improve transmission durability
  • Engineered with a proprietary blend of base oils and advanced additives to provide better oil flow at low temperatures and greater film protection at higher temperatures
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National – Shaft Repair Sleeve (Part No.99177)

Shaft Repair Sleeve

from

$39.99
National has built a reputation as one of the most respected names in the industry. We have offered premium sealing solutions for more than 75 years. Our design team keeps pace with the industry and provides advanced solutions for today’s vehicles.

Product Features:
  • Designed to repair damaged, grooved or worn shafts
  • Durable stainless steel construction for corrosion-free sealing surface that surpasses most original shaft specifications
  • Ideal for a shaft where indications of seal wear, such as tracks or grooves have developed
  • Ultra-thin construction (0.01/0.25mm wall thickness) allows original seal size to be used with minimal additional lip loading
  • Easy to install with removable flange and installation tool
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National – Multi-Purpose Bearing (Part No.A-18)

Multi-Purpose Bearing

from

$17.99
Product Features:
  • CONSISTENT PERFORMANCE: Matched cup and cone components ensure consistent performance
  • PREMIUM MATERIALS: Precision manufactured using premium-grade steel for outstanding durability and performance
  • SMOOTH ROTATION: Crowned raceways and rollers for even load distribution
  • OE-STYLE DESIGN: Engineered to meet OE specifications
  • COMPREHENSIVE COVERAGE: Industry-leading coverage for domestic and import applications
  • RIGOROUS TESTING: Comprehensive testing throughout design and development processes by National engineers for quality you can count on
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National – Bearing Race (Part No.M86610)

Bearing Race

from

$9.99
Manufactured with premium-grade steel, National taper bearing cups feature crowned raceways to ensure even load distribution.

Product Features:
  • PREMIUM MATERIALS – Precision manufactured using premium-grade steel for outstanding durability and performance
  • SMOOTH ROTATION – Crowned raceways for even load distribution
  • OE-STYLE DESIGN – Engineered to meet OE specifications
  • COMPREHENSIVE COVERAGE – Industry-leading coverage for domestic and import applications
  • RIGOROUS TESTING – Comprehensive testing throughout design and development processes by National engineers for quality you can count on
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National – Multi-Purpose Bearing (Part No.206)

Multi-Purpose Bearing

from

$24.99
Product Features:
  • BUILT TO LAST: Advanced heat treatment process for strength
  • PREMIUM MATERIALS: Precision manufactured using premium-grade steel for lasting performance and extended bearing life
  • RELIABLE PERFORMANCE: Element size and quantity are engineered to meet or exceed the load rating of OE bearings
  • COMPREHENSIVE COVERAGE: Industry-leading coverage for domestic and import applications
  • RIGOROUS TESTING: Comprehensive testing throughout design and development processes by National engineers for quality you can count on
See More

Driveworks – Tapered Roller Bearing (Part No.S-32010X)

Tapered Roller Bearing

from

$28.99
Product Features:
  • Brand may vary by location
See More

Driveworks – Camshaft Seal (Part No.S-99139)

Camshaft Seal

from

$23.99
Product Features:
  • Brand may vary by location
See More

Top-Rated Drivetrains Brands For Your 2006 Mercedes-Benz E350

Shop for the best-rated brands offering Drivetrains and other products for your 2006 Mercedes-Benz E350s. Below you’ll find some of our best rated Drivetrains from Valvoline, National, and Driveworks, and more. Drivetrains from these brands that fit a 2006 E350 start at just $9.99 and are rated as high as 4.8 stars. OEM and aftermarket Drivetrains don’t get more top quality, durable, and affordable than from the brands below.

Popular Valvoline 2006 Mercedes-Benz E350 Drivetrains

When it comes to maintaining or upgrading your 2006 Mercedes-Benz E350, using quality Drivetrains is essential to ensure durability and a perfect fit. Valvoline ticks all of those boxes. We offer a wide selection of Valvoline Drivetrains, specifically designed for the 2006 Mercedes-Benz E350. With over 1 Valvoline brand Drivetrains in stock, you’re sure to find what you need. The prices for these top-notch parts start as low as $35.99. Plus, with over 446 customer reviews and an average rating of 4.8 stars, you can trust that our Valvoline Drivetrains will get the job done right. Choose Advance Auto Parts for reliability, quality, and expert-approved parts that keep your vehicle running strong.
MaxLife Multi-Vehicle Automatic Transmission Fluid, 1 Gallon
from $35.99
(446)
MaxLife Multi-Vehicle Automatic Transmission Fluid, 1 Gallon
“Good quality great price”

Popular National 2006 Mercedes-Benz E350 Drivetrains

National auto parts is one of the highest quality Drivetrain brands in the market. Any 2006 Mercedes-Benz E350 owner should feel confident when installing genuine National parts in their vehicle. To ensure the best fit and performance for your 2006 E350, Advance Auto Parts carries a full inventory of 3 National Drivetrains. Plus you will be keeping your Mercedes-Benz in peak condition while saving money because prices on these National Drivetrains range from $17.99 to $39.99, plus, with more than 38 customer reviews and an impressive 4.3 stars average rating, you can be confident the Fram Drivetrains below will deliver on both quality and value.
Shaft Repair Sleeve
from $39.99
(1)
Shaft Repair Sleeve
“used these speedy sleeves on the front axle of my Kubota with the wheel seals,saved me from spending 15 times more on the axle’s, Thank’s”
Shaft Repair Sleeve
from $39.99
(1)
Shaft Repair Sleeve
“Easy to use, too early to tell how long it will last. It did stop the oil leak with a new oil seal on the front crankshaft pulley. 87 mercedes 300td.”
Multi-Purpose Bearing
from $17.99
(36)
Multi-Purpose Bearing
“High quality.”

FAQs for 2006 Mercedes-Benz E350 Drivetrains

Which Drivetrains are best-sellers for 2006 Mercedes-Benz E350s?

Out of 23 Drivetrains that fit 2006 Mercedes-Benz E350s, the following parts are the top sellers:

What’s the price range for 2006 Mercedes-Benz E350 Drivetrains?

Drivetrain prices for the 2006 Mercedes-Benz E350 start at $6.99 and go up to $1,080.99 for the most premium parts.

What’s the average price of a Drivetrain for a 2006 Mercedes-Benz E350?

The average price for Drivetrains for the 2006 Mercedes-Benz E350 is $105.72. Keep in mind the variety of part types within our Drivetrain category so you are likely to find a wide range of prices across a variety of parts and components.

Does Advance Auto Parts sell Drivetrains for other Mercedes-Benz E350 model years?

Yes, we currently carry Drivetrains for 16 model years of Mercedes-Benz E350s between 2007 and 2026. Drivetrains are bought most frequently for the following model years: 2023, 2022, 2021, 2020, 2016, 2015, 2014, 2013, and 2012.

What are the cheapest Drivetrains for my 2006 Mercedes-Benz E350?

The cheapest 2006 Mercedes-Benz E350 Drivetrains we carry in stock are:

What are the top-rated Drivetrains that fit the 2006 Mercedes-Benz E350?

Out of 1,111 reviews by customers, our 2006 Mercedes-Benz E350 Drivetrains have an average customer rating of . These are some of the highest-rated Drivetrain types for the 2006 Mercedes-Benz E350 and their top-rated products:

What types of Drivetrains do you sell for my 2006 Mercedes-Benz E350?

As of 3/1/26, these are some of the most in-demand types of Drivetrains for a 2006 Mercedes-Benz E350:

Can I get help with 2006 Mercedes-Benz E350 Drivetrain orders?

Contact our customer support team, by chat or phone, through the help desk page, where you can find instant answers about Mercedes-Benz Drivetrains and more.

What is your return policy for Mercedes-Benz E350 Drivetrains?

Advance Auto Parts keeps returns simple. For new Mercedes-Benz E350 Drivetrains and accessories, your online orders can be returned, in their original condition, within 45 days. For requirements, see the returns page.