2001 GMC Sierra 2500 HD Spark Plugs

Essential 2001 GMC Sierra 2500 HD Spark Plugs

ACDelco – Spark Plug Wire Set (Part No.356F)

Spark Plug Wire Set

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$28.99
ACDelco GM Original Equipment Spark Plug Wires consist of a single wire, encased in an insulating material, connectors, and insulating boots, and are GM-recommended replacements for your vehicle’s original components. The wires transfer high voltage pulses between the voltage source, the distributor, and the spark plug. These original equipment wires have been manufactured to fit your GM vehicle, providing the same performance, durability, and service life you expect from General Motors.

Product Features:
  • Durable to help transfer high voltage pulses without damage
  • GM-recommended replacement part for your GM vehicle’s original factory component
  • Offering the quality, reliability, and durability of GM OE
  • Manufactured to GM OE specification for fit, form, and function
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ACDelco – Specific FitSpark Plug Wire (Part No.349V)

Specific FitSpark Plug Wire

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$19.99
ACDelco GM Original Equipment Spark Plug Wires consist of a single wire, encased in an insulating material, connectors, and insulating boots, and are GM-recommended replacements for your vehicle’s original components. The wires transfer high voltage pulses between the voltage source, the distributor, and the spark plug. These original equipment wires have been manufactured to fit your GM vehicle, providing the same performance, durability, and service life you expect from General Motors.

Product Features:
  • Durable to help transfer high voltage pulses without damage
  • GM-recommended replacement part for your GM vehicle’s original factory component
  • Offering the quality, reliability, and durability of GM OE
  • Manufactured to GM OE specification for fit, form, and function
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ACDelco – Original Equipment Ignition Wire (Part No.F1030575906ACD)

Original Equipment Ignition Wire

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$30.10
Built to match the original equipment in length and fit, ACDelco OES Ignition Wires offer a performance advantage over many aftermarket products.

Product Features:
  • ACDelco ignition wires are designed to be like Original in critical areas such as cable length and diameter, terminal design and insulator position
  • Have broad coverage available for most vehicles on the road today from 1980 to present
  • Provide a high degree of Radio Frequency Interference (RFI) suppression
  • Are designed to offer fit, form and function for optimum performance
  • Kevlar reinforced fiberglass core in select sets for increased strength
  • Core sheathed in radio-static absorbent material for increased RFI suppression
  • Wire-wound, stainless steel alloy conductor for maximum spark delivery and RFI suppression on most applications
  • A layer of conductive heat-resistant latex for added durability
  • Insulating rubber-based compound inner jacket helps minimize voltage drop and enhance durability
  • Thick silicone outer jacket for excellent heat resistance
  • Limited lifetime warranty*
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GM Genuine Parts – Spark Plug Wire (Part No.12716289)

Spark Plug Wire

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$17.99
GM Genuine Parts Genuine GM Spark Plug Wires are designed, engineered, and tested to rigorous standards, and are backed by General Motors. These wires are a single wire encased in an insulating material, and contains connectors and insulating boots. It transfers high voltage pulses between the voltage source, the distributor, and your vehicle’s spark plug. GM Genuine Parts are the true OE parts installed during the production of or validated by General Motors for GM vehicles. Some GM Genuine Parts may have formerly appeared as ACDelco GM Original Equipment (OE).

Product Features:
  • Durable to help transfer high voltage pulses without damage
  • Some GM Genuine Parts may have formerly appeared as ACDelco GM Original Equipment (OE)
  • GM Genuine Parts are designed, engineered and tested to rigorous standards, and are backed by General Motors
  • GM Engineers design and validate OE parts specifically for your Chevrolet, Buick, GMC, or Cadillac vehicle
  • GM regularly updates production and service part designs to integrate new materials and technologies
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ACDelco – Spark Plug Wire (Part No.350R)

Spark Plug Wire

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$24.99
ACDelco GM Original Equipment Spark Plug Wires consist of a single wire, encased in an insulating material, connectors, and insulating boots, and are GM-recommended replacements for your vehicle’s original components. The wires transfer high voltage pulses between the voltage source, the distributor, and the spark plug. These original equipment wires have been manufactured to fit your GM vehicle, providing the same performance, durability, and service life you expect from General Motors.

Product Features:
  • Durable to help transfer high voltage pulses without damage
  • GM-recommended replacement part for your GM vehicle’s original factory component
  • Offering the quality, reliability, and durability of GM OE
  • Manufactured to GM OE specification for fit, form, and function
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DENSO – PT16TT Platinum TT Spark Plug (Part No.4511)

PT16TT Platinum TT Spark Plug

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$5.99
Twin-Tip design enables faster flame propagation for more complete combustion.
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NGK – Iridium IX Spark Plug (Part No.F100089175NGK)

Iridium IX Spark Plug

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$12.74
The NGK Iridium IX offers extreme ignitability, improved throttle response and superior anti fouling properties. The Iridium alloy has extremely high melting point, ensuring high durability and a consistently stable spark that is perfect for today’s high-tech, high-performance engines. NGK’s IX Iridium Series Plugs were Designed Specifically for the Performance Enthusiast Designed specifically for the performance enthusiast.

Product Features:
  • Fine Wire Center Electrode Ensures High Durability and a Consistently Stable Spark
  • Iridium Alloy has an Extremely High Melting Point, Perfect for Today’s High-Tech, High Performance Engines
  • Trivalent Metal Plating Provides Superior Anti-Corrosion and Anti-Seizing Properties
  • Corrugated Ribs Prevent Flashover
  • Pure Alumina Silicate Ceramic Insulator, Provides Superior Strength and Better Heat Transfer
  • Copper Core Aids in Heat Removal
  • Triple Seals Prevent Leakage
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E3 – DiamondFIRE Automotive Spark Plug: More Power, Saves Gas (Part No.E3.44)

DiamondFIRE Automotive Spark Plug: More Power, Saves Gas

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$6.99
The Spark Plugs are the product of years of fundamental research in the combustion field. The unique patented electrode configuration of these new The spark plugs increases the amount of combustion pressure created during each power stroke of an engine, which results in a marked increase in power output, fuel economy, and reduced emissions in all gasoline engines. E3.44 is a 14mm, 0.708 reach plug with a taper seat. It fits domestic applications from the mid-90s. The automotive plugs have three legs securing the Diamond FIRE electrode to the shell. This allows for excellent heat transfer, and helps to create more turbulence in the cylinder. The patented Diamond FIRE side wire is proven to increase power, reduce fuel consumption and improve hydrocarbon emissions in long-term use.

Product Features:
  • E3’s Diamond Fire edge to edge ground electrode provides maximum performance with increased efficiency and a faster more complete burn.
  • Smoother Acceleration & Idle – The faster flame initiated by the The spark plug results in a more complete burn of the ingested fuel charge. More pressure is created against the piston more fuel is put to work
  • Energy – Power output improved up to 6% on average in the typical operating ranges. Results will vary.
  • Efficiency – The “diamond shaped” side wire electrode projects the combustion spark in a way that more quickly ignites the air/fuel mixture, thereby creating a significantly faster and larger flame kernel. The result is that more fuel is put to work durin
  • E3’s patented Diamond Fire Technology provides a cleaner burning combustion, which translates into fuel savings and reduced engine carbon deposits
  • The Spark Plugs are pre-gapped at the factory and cannot be adjusted.
  • Patented Electrode Configuration: The unique patented electrode design of the E3.44 spark plugs increases combustion pressure, resulting in enhanced power output and improved fuel economy.
  • Superior Heat Transfer: The three-leg design securing the Diamond FIRE electrode to the shell ensures excellent heat transfer and creates more turbulence in the cylinder for optimal performance.
  • Compatibility: The E3.44 spark plug is a 14mm, 0.708 reach plug with a taper seat, fitting domestic applications from the mid-90s.
  • Environmental Benefits: By improving combustion efficiency, these spark plugs help reduce emissions, contributing to a cleaner environment.
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Autolite – Copper Spark Plug: Delivers Quick Starts, Good Fuel Economy, Smooth Acceleration (Part No.5245)

Copper Spark Plug: Delivers Quick Starts, Good Fuel Economy, Smooth Acceleration

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$3.49
With over 100 years of engineering expertise and over 11 billion plugs sold, Autolite continues to set the standard in spark plug technology. Designed and engineered in the USA, these spark plugs feature a copper cored center electrode for higher thermal conductivity, a specially engineered high nickel alloy center and ground electrode for extended life, and high alumina ceramic for high dielectric strength. Additionally, the leak-proof, heat-fused internal seal ensures durability, while the multi-rib insulator prevents flash-over, making these plugs a reliable choice for enhancing your vehicle’s performance.

Product Features:
  • Copper cored center electrode for higher thermal conductivity
  • Specially engineered high nickel alloy center and ground electrode for extended life
  • High alumina ceramic for high dielectric strength
  • Leak proof, heat fused internal seal for durability
  • Multi-rib insulator prevents flash-over
  • Quick Starts: The Autolite Copper Spark Plug ensures quick engine starts, enhancing your vehicle’s reliability and performance.
  • Good Fuel Economy: Designed to optimize fuel efficiency, these spark plugs help you save on fuel costs while maintaining excellent engine performance.
  • Smooth Acceleration: Experience smoother acceleration with the high-quality engineering of Autolite Copper Spark Plugs, providing a more responsive driving experience.
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DENSO – Iridium Long-Life Spark Plug: OE Performance, last 100K+ Miles, ZTJ16VR10 (Part No.3539)

Iridium Long-Life Spark Plug:  OE Performance, last 100K+ Miles, ZTJ16VR10

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$9.99
Manufactured to the strictest OE performance, durability and emissions standards.

Product Features:
  • Latest OE technology with DENSO’s patented Iridium Alloy (90% Ir) and fine wire center electrode
  • Platinum ground electrode for extended life
  • DENSO Patented 360 degree laser welding process: Ensuring exceptional quality bond and structural strength with the Iridium Center Electrode
  • Sustained spark performance over 100,000 miles
  • Lasts up to three times as long as conventional plugs
  • Endures extreme temperatures greater than 4,000 degrees F associated with high-performance ignition and special fuel systems
  • Iridium Long Life
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NGK – OE Series V-Power Nickel Spark Plug: V-Groove Tip Design, TR55 (Part No.3951)

OE Series V-Power Nickel Spark Plug: V-Groove Tip Design, TR55

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$4.99
NGK V-Power spark plugs offer reliable performance and improved ignitability over standard nickel plugs. Engineered specifically for OE applications, the special V-cut nickel alloy center electrode and concave ground electrode of NGK’s V-Power spark plug increases ignitability providing quicker starts and smoother idle. NGK’s legendary high grade alumina silicate ceramic creates a stronger insulator for optimal dielectric performance. Trivalent metal plating ensures superior anti-corrosion and anti-seizing properties.

Product Features:
  • ACTUAL OE or EQUIVALENT DESIGN: OEM quality construction nickel alloy center electrode with V-groove provides consistent performance
  • RECOMMENDED USAGE: Best for vehicles with OE nickel alloy plugs, not recommended on vehicles with factory precious metal plugs
  • NGK’s OE CERAMIC TECHNOLOGY: High grade alumina silicate ceramic creates a stronger insulator for optimal dielectric performance
  • SOLID COPPER CORE: 98% pure copper core offers superior heat dissipation, conductivity and ultra wide heat ranges
  • COLD-ROLLED THREADS: Prevents cross-threading and damage to cylinder heads
  • TRIVALENT METAL PLATING: Delivers superior anti-corrosion and anti-seizing properties, ensuring ease of installation and removal
  • Enhanced Ignitability: The V-cut nickel alloy center electrode and concave ground electrode design of NGK V-Power spark plugs provide quicker starts and smoother idle.
  • OE Application Specific: Engineered specifically for Original Equipment (OE) applications, ensuring compatibility and reliable performance.
  • V-Groove Tip Design: The unique V-Groove tip design of the TR55 model enhances ignitability and overall engine performance.
  • Lower Emissions: The NGK Laser Platinum Spark Plug contributes to lower emissions, supporting a cleaner and more environmentally friendly driving experience.
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DENSO – Double Platinum Spark Plug: OE Performance, lasts 60K+ Miles, PTJ16R15 (Part No.5077)

Double Platinum Spark Plug:  OE Performance, lasts 60K+ Miles, PTJ16R15

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$9.49
Manufactured to the strictest OE performance, durability and emissions standards.

Product Features:
  • OE grade platinum on both center and ground electrodes
  • Premium shell construction with machine-rolled threads
  • Superior thermal conductivity
  • Sustained spark performance over 60,000 miles
  • Reduced secondary required voltage, increased ignition efficiency
  • Satisfied customers, reduced shop comebacks
  • Double Platinum
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DENSO – Iridium Power Spark Plug: Maximum Spark Energy, 0.4mm Iridium Tip, IT16 (Part No.5325)

Iridium Power Spark Plug: Maximum Spark Energy, 0.4mm Iridium Tip, IT16

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$11.79
Increased performance with World’s smallest Iridium Center Eletrode (0.4mm).

Product Features:
  • World’s smallest Iridium Center Electrode (0.4mm) for improved spark for maximum combustion
  • Patented 360-degree laser welding assembly process
  • U-groove and taper cut ground electrode to maximize flame propagation.
  • Withstands temperatures greater than 4000° Fahrenheit
  • Burnished nickel plating for high temperature endurance and superior corrosion resistance
  • Wide range of part numbers for thousands of applications, including classic and collector cars
  • Iridium Power
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NGK – V Power Spark Plug (Part No.F100037153NGK)

V Power Spark Plug

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$4.69
The NGK V Power spark plug offers a 90 degree V-Power center copper or platinum electrode that provides performance, improved ignitability, increased fuel economy and lower emissions over standard Spark Plugs. The Trivalent Metal Plating has superior anti-corrosion and anti-seizing properties. NGK’s V-Power Plugs Feature a Unique V-Cut in the Center Electrode that Directs the Spark to the Edge of the Electrode, Helping the Spark Develop More Rapidly, Increasing Ignitability and Reducing Quenching.

Product Features:
  • Lowers ignition system voltage requirements
  • Greater ignitability and performance over conventional spark plugs
  • Corrugated Ribs Prevent Flashover
  • Trivalent Metal Plating has superior anti-corrosion and anti-seizing properties
  • Pure Alumina Silicate Ceramic Insulator, Provides Superior Strength and Better Heat Transfer
  • Increased fuel economy and lower emissions
  • Highly durable against electrical and chemical wear
  • Triple Seals Prevent Leakage Economical performance and improved ignitability over standard NGK Spark Plugs original equipment manufacturer and racer approved.
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DENSO – Iridium Power Spark Plug (Part No.F1000131221ND)

Iridium Power Spark Plug

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$12.52
DENSO Iridium Power spark plugs represent a performance breakthrough. The laser-welded center electrode is only 0.4mm in diameter – the slimmest iridium electrode in the industry. The taper-cut side electrode complements the design, delivering reliable spark energy under the most gruelling pressures and temperatures. DENSO engineers used the power of this miraculous metal to produce an iridium center electrode that is only 0.4mm in diameter. With its superior thermal qualities, this whisker-fine electrode is capable of taking the most extreme heat and punishment. This breakthrough was matched to one of DENSO’s most famous innovations, the patented U-Groove ground electrode. The combination of these two features resulted in the Iridium Power® plug, one of the most advanced and innovative spark plugs on the market.

Product Features:
  • Tapered cut, U-Groove ground electrode
  • 0.4mm iridium center electrode
  • 360-degree laser welding assembly process
  • Required ignition voltage reduced
  • Unsurpassed center electrode durability
  • Available for many performance and power sports applications, including Corvette, Viper, and Harley-Davidson The Iridium Power plug delivers greater spark energy while demanding significantly less secondary required voltage from the ignition system.
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NGK – Ruthenium HX High Ignitability Spark Plug: DFE Tip Design, TR5AHX (Part No.94567)

Ruthenium HX High Ignitability Spark Plug: DFE Tip Design, TR5AHX

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$14.99
NGK Ruthenium HX High Ignitability spark plugs are the best in class plug for todays modern vehicles. Patented Ruthenium technology offers the most advance tip technology and delivers the highest performance and life expectancy. Created from advanced OE technology as a high ignitability plug; Ruthenium HX spark plugs come with patented, specialized OEM DFE and PSPE tip designs. NGK Ruthenium HX High Ignitability spark plugs provide a more complete fuel burn resulting in a quicker throttle response, smoother idle and better cold starts. Ruthenium center electrode provides industry leading durability.

Product Features:
  • HIGH IGNITABILITY DOUBLE FINE ELECTRODE DESIGN: Combines 0.6 millimeter ruthenium center with opposed fine wire platinum ground electrode
  • RUTHENIUM ALLOY CENTER ELECTRODE: NGK’s patented ruthenium technology produces maximum performance, ignitability & durability at high temperatures
  • PLATINUM PIN TYPE GROUND ELECTRODE: Provides more complete fuel burn, quicker throttle response, smoother idle and better cold starts
  • SOLID COPPER CORE: 98% pure copper core offers superior heat dissipation, conductivity and ultra wide heat ranges
  • TRIVALENT METAL PLATING: Delivers superior anti-corrosion and anti-seizing properties, ensuring ease of installation and removal
  • RECOMMENDED USAGE: Modern vehicles using OE DFE type spark plugs or for those seeking an aftermarket plug with the latest OE technology
  • Specialized OEM Tip Designs: Features DFE and PSPE tip designs for enhanced ignitability and efficiency.
  • Industry-Leading Durability: Ruthenium center electrode ensures long-lasting performance and reliability.
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GM Genuine Parts – Spark Plug Wire Heat Shield (Part No.8006)

Spark Plug Wire Heat Shield

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$8.49
ACDelco GM Original Equipment Spark Plug Heat Shields help protect the spark plug insulator and plug wire boot from the heat of the exhaust manifold, and are GM-recommended replacements for your vehicle’s original components. These original equipment heat shields have been manufactured to fit your GM vehicle, providing the same performance, durability, and service life you expect from General Motors.

Product Features:
  • Helps protect spark plug boot from cracking and deteriorating from heat
  • GM-recommended replacement part for your GM vehicle’s original factory component
  • Offering the quality, reliability, and durability of GM OE
  • Manufactured to GM OE specification for fit, form, and function
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2001 GMC Sierra 2500 HD Spark Plugs

Maybe you’re in the middle of a full rebuild of that 2001 GMC Sierra 2500 HD. Maybe you just need a couple of Spark Plugs. Either way, Advance Auto Parts has 52 different Spark Plugs in our inventory ranging from $2.99 to $30.10. That means you can find the exact parts or products you need to keep that 2001 GMC Sierra 2500 HD running smoothly.

Spark Plugs are only as good as their brand. We stock 9 different brands to make sure you have plenty of trusted parts to choose from for your 2001 GMC Sierra 2500 HD. NGK, ACDelco, and Autolite are just some of the brands we stock. Search for brands you know or compare prices and reviews to help you decide!

We know you’ll find the perfect Spark Plugs for your 2001 GMC Sierra 2500 HD, but don’t take our word for it – read our customer ratings and reviews and buy with confidence. Out of the 6,888 reviews in this category, some of the top rated parts include Copper Spark Plug: Delivers Quick Starts, Good Fuel Economy, Smooth Acceleration with 4.7 stars and Iridium IX Spark Plug: Single Iridium Fine Wire, TR55IX with 4.8 stars.

So if you’re in the market for aftermarket Spark Plugs to keep your 2001 GMC Sierra 2500 HD rolling for years to come, look no further. Shop online and have your products shipped direct to your door, or pick up at the nearest Advance Auto Parts location today!

Spark Plugs Brands To Make Your 2001 GMC Sierra 2500 HD Last

Simple repair, complete replacement, or a full rebuild. No matter the job, your 2001 GMC Sierra 2500 HD demands trusted brand parts and products to keep it running. Many trusted brands of Spark Plugs make up Advance Auto Parts’ inventory, and all are ready to help make your Sierra 2500 HD the best it can be. Be sure to browse some of our top Spark Plugs brands and parts.

Popular Motorcraft Spark Plugs

We carry Motorcraft parts in our stock across Spark Plugs categories, plus more. For a 2001 GMC Sierra 2500 HD, our most popular Motorcraft Spark Plugs include:
Spark Plug (AGSF52C)
from $3.29
(1)
Spark Plug (AGSF52C)
Spark Plugs

FAQs for 2001 GMC Sierra 2500 HD Spark Plugs

What are the most purchased Spark Plugs for the 2001 GMC Sierra 2500 HD?

Out of 52 Spark Plugs for the 2001 GMC Sierra 2500 HD, the most popular in our inventory are:
Iridium XP Finewire Spark Plug: Improved Durability, More Focused Ignition
from $9.99
This product is not rated
Iridium XP Finewire Spark Plug: Improved Durability, More Focused Ignition
Spark Plugs

What are the top-rated 2001 GMC Sierra 2500 HD Spark Plugs?

Top-rated Spark Plugs for your 2001 GMC Sierra 2500 HD based on customer reviews/ratings are:
Iridium IX Spark Plug: Single Iridium Fine Wire, TR55IX
from $11.99
(103)
Iridium IX Spark Plug: Single Iridium Fine Wire, TR55IX
“2000 GT Mustang had bad misfire These plugs made the car run like new again.OE plugs just would not last.”
DiamondFIRE Automotive Spark Plug: More Power, Saves Gas
from $7.29
(98)
DiamondFIRE Automotive Spark Plug: More Power, Saves Gas
“These are awesome. They are in my 02 sierra 4.8l. And i have 4mpg better than before.”