Lexus IS350 Transmission Fluids

Your One-Stop Shop For Trusted Lexus IS350 Transmission Fluids

If you’re in search of Lexus IS350 Transmission Fluids aftermarket or OEM parts, consider your search over! Advance Auto Parts carries 19 Transmission Fluids from top brands with prices ranging from $8.29 to $1,549.99.

Beyond great prices, we stock trusted brands manufacturing all types of Transmission Fluids for your Lexus IS350.

And don’t forget to read customer reviews across all Transmission Fluids categories in our catalog. Buy with confidence by leveraging past customer experiences of our aftermarket and OEM parts.

At Advance Auto Parts, we don’t think top quality Transmission Fluids have to cost top dollar, and we prove it. Browse our top Lexus IS350 Transmission Fluids below, order online to ship to your home, or head into your nearest Advance Auto Parts location to get started.

Please Select your Vehicle to See Exact Fit Parts

Essential Lexus IS350 Transmission Fluids

Valvoline – High Mileage 0W-20 Synthetic Blend Motor Oil, Prevents Engine Breakdown, 5 Quart (Part No.881149)

High Mileage 0W-20 Synthetic Blend Motor Oil, Prevents Engine Breakdown, 5 Quart

from

$29.99
Maybe you’re spending extra money to top off oil between changes. Or maybe you’re noticing oil leaks in your driveway. Either way, it’s an obvious sign your vehicle needs a high mileage motor oil. If left untreated, the issues could eventually lead to engine breakdown. Other problems with aging engines may be less obvious but can still be just as harmful. After 75,000 miles, your vehicle deserves Valvoline High Mileage Motor Oil with premium seal conditioners seal conditioners to rejuvenate aging seals and prevent oil leaks. Our synthetic blend formula and superior-quality additives protect against engine deposits, wear, friction and extreme heat, the four leading causes of engine failure. Plus, added detergents reduce sludge, corrosion and deposits. Toyota, Ford, Chevy, Dodge, Honda, Hyundai ¿ cars, SUVs, trucks ¿ no matter the make or model, Valvoline High Mileage with MaxLife Technology helps curb contaminants to keep high-mileage engines from burning and consuming oil. Valvoline Synthetic Blend High Mileage with MaxLife Technology, America’s first motor oil to specifically address the needs of higher mileage vehicles.

Product Features:


    Product Features:
    • MaxLife Technology prevents engine breakdown with 40% better wear protection than the industry standard
    • Includes seal conditioners to reduce oil consumption and oil leaks in high mileage engines.
    • Added detergents reduce sludge, corrosion, rust and deposits to help keep motors clean inside and ensure a smooth-running engine.
    • Advanced friction-fighting additives help maximize performance and improve fuel efficiency.
    • Designed to protect against extreme heat, the synthetic blend formula helps maintain engine durability and reliability in high-mileage vehicles.
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Valvoline – Advanced Full Synthetic 0W-20 Engine Oil, Maximizes Engine Life, 1 Quart (Part No.VV916)

Advanced Full Synthetic 0W-20 Engine Oil, Maximizes Engine Life, 1 Quart

from

$11.49
The Valvoline Advanced Full Synthetic 0W-20 Motor Oil is a high-quality engine oil that is designed to maximize the life of your engine. This product is available in a 1-quart size and is formulated with conventional oil composition. The oil class is standard and the SAE oil weight is 0W-20. This engine oil is perfect for those who want to keep their engine running smoothly and efficiently. It is designed to provide superior protection against wear and tear, as well as reduce engine deposits and sludge. With its advanced formula, this motor oil is sure to keep your engine running at its best for years to come. If you want to ensure the longevity of your engine, the Valvoline Advanced Full Synthetic 0W-20 Motor Oil is an excellent choice.

Product Features:
  • ADVANCED PROTECTION AGAINST the four main causes of engine breakdown: wear friction heat and deposits
  • 40% BETTER WEAR PROTECTION vs. industry standard as tested in the Sequence IVB engine test
  • 25% BETTER DEPOSIT PROTECTION with superior engine cleaning detergents as tested in the GMOD engine test
  • EXCEPTIONAL HIGH/LOW TEMPERATURE PROTECTION defends your motor no matter the weather conditions
  • MEETS OR EXCEEDS ALL REQUIREMENTS of ILSAC GF-6A, API SP, API SN with SN PLUS, API SN, GM dexos 1 Gen 3
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Royal Purple – HMX 5W-20 High Mileage Synthetic Motor Oil, Restores Engine Performance, 5 Quart (Part No.17518)

HMX 5W-20 High Mileage Synthetic Motor Oil, Restores Engine Performance, 5 Quart

from

$65.99
Royal Purple HMX SAE 5W-20 High-Mileage Synthetic Motor Oil, 5 quart is specifically designed to minimize wear and restore lost performance in engines with more than 75,000 miles. Formulated with robust zinc/phosphorus anti-wear compounds combined with Royal Purple’s proprietary additive technology Synerlec, HMX is chemically enhanced to revitalize hardened seals, reducing oil consumption common in high-mileage engines. In addition, HMX is fortified with stout detergents to remove engine build-up and deposits, maintain cleanliness and promote engine longevity.

Product Features:
  • Specifically designed to minimize wear and restore lost performance in engines with more than 75,000 miles
  • Formulated with robust zinc/phosphorus anti-wear compounds combined with Royal Purple’s proprietary additive technology
  • HMX is chemically enhanced to revitalize hardened seals, reducing oil consumption common in high-mileage engines
  • Reduces friction and metal-to-metal contact for peak engine performance
  • Also provides outstanding oxidation resistance to safely extend oil drain intervals, and an ionic attraction to metal surfaces, providing protection and minimizing wear at start-up
  • Superior Engine Cleanliness: Fortified with stout detergents, this oil effectively removes engine build-up and deposits, maintaining cleanliness and promoting engine longevity.
  • High-Mileage Protection: Classified as a high-mileage oil, it provides specialized protection for older engines, ensuring they run smoothly and efficiently.
  • Synthetic Composition: With a synthetic oil composition and an SAE weight of 5W-20, it offers excellent performance and protection in a wide range of temperatures.
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Royal Purple – HMX 5W-30 High Mileage Synthetic Motor Oil, Restores Engine Performance, 5 Quart (Part No.11748)

HMX 5W-30 High Mileage Synthetic Motor Oil, Restores Engine Performance, 5 Quart

from

$66.99
Royal Purple HMX SAE 5W-30 High-Mileage Synthetic Motor Oil, 5 quart is specifically designed to minimize wear and restore lost performance in engines with more than 75,000 miles. Formulated with robust zinc/phosphorus anti-wear compounds combined with Royal Purple’s proprietary additive technology Synerlec, HMX is chemically enhanced to revitalize hardened seals, reducing oil consumption common in high-mileage engines. In addition, HMX is fortified with stout detergents to remove engine build-up and deposits, maintain cleanliness and promote engine longevity. 

Product Features:
  • Specifically designed to minimize wear and restore lost performance in engines with more than 75,000 miles
  • Formulated with robust zinc/phosphorus anti-wear compounds combined with Royal Purple’s proprietary additive technology
  • HMX is chemically enhanced to revitalize hardened seals, reducing oil consumption common in high-mileage engines
  • Reduces friction and metal-to-metal contact for peak engine performance
  • Also provides outstanding oxidation resistance to safely extend oil drain intervals, and an ionic attraction to metal surfaces, providing protection and minimizing wear at start-up
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Royal Purple – High Performance 5W-30 Synthetic Motor Oil, Better Wear Protection, 1 Quart (Part No.01530)

High Performance 5W-30 Synthetic Motor Oil, Better Wear Protection, 1 Quart

from

$11.99
High Performance Motor Oil API LICENSED MOTOR OIL Royal Purple High Performance Motor Oil combines premium base oils with proprietary additive technologies to create a high performance synthetic engine oil that optimizes performance and protection. Royal Purple High Performance Motor Oils carry the current API and ILSAC engine oil licenses, as well as the GM dexos1 gasoline engine oil approval. ILSAC GF-6 AND GM DEXOS1 Modern gasoline direct injection (GDI) engines have achieved levels of power and fuel economy never before possible in passenger car engines. As a result, smaller engines operate at much higher loads across all engine speeds. This has caused increased wear in critical areas of the engine, and created a destructive phenomenon called low-speed pre-ignition (LSPI). The unique, state-of-the-art additive technology in Royal Purple High Performance engine oils is designed specifically to address these issues, and help engines maintain performance and reliability.

Product Features:
  • Better Wear Protection
  • Increased Protection against Low Speed Pre-Ignition
  • Increased Fuel Efficiency
  • Better Protection for Vehicle Exhaust Emissions Equipment
  • Improved Compatibility with Fuels Containing Ethanol
  • Superior Corrosion Protection
  • Made in USA
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Royal Purple – HMX 5W-30 High Mileage Synthetic Oil, Restores Lost Performance, 1 Quart (Part No.11744)

HMX 5W-30 High Mileage Synthetic Oil, Restores Lost Performance, 1 Quart

from

$1549.99
Royal Purple HMX SAE 5W-30 High-Mileage Synthetic Motor Oil, 1 quart is specifically designed to minimize wear and restore lost performance in engines with more than 75,000 miles. Formulated with robust zinc/phosphorus anti-wear compounds combined with Royal Purple’s proprietary additive technology Synerlec, HMX is chemically enhanced to revitalize hardened seals, reducing oil consumption common in high-mileage engines. In addition, HMX is fortified with stout detergents to remove engine build-up and deposits, maintain cleanliness and promote engine longevity.

Product Features:
  • Specifically designed to minimize wear and restore lost performance in engines with more than 75,000 miles
  • Formulated with robust zinc/phosphorus anti-wear compounds combined with royal purple’s proprietary additive technology
  • Hmx is chemically enhanced to revitalize hardened seals, reducing oil consumption common in high-mileage engines
  • Reduces friction and metal-to-metal contact for peak engine performance
  • Also provides outstanding oxidation resistance to safely extend oil drain intervals, and an ionic attraction to metal surfaces, providing protection and minimizing wear at start-up
  • High-Mileage Formula: Specifically designed for engines with more than 75,000 miles, this full synthetic engine oil helps minimize wear and restore lost performance.
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Valvoline – Advanced Full Synthetic 5W-30 Motor Oil, Maximizes Engine Life, 5 Quart (Part No.881164)

Advanced Full Synthetic 5W-30 Motor Oil, Maximizes Engine Life, 5 Quart

from

$36.99
Today’s advanced engine technology requires advanced protection. Valvoline Advanced Full Synthetic, the motor oil designed to protect today’s sophisticated engines, contains premium anti-wear additives, superior antioxidants and extra detergents. It protects 40% better against wear, resists oil breakdown 10-times better, and defends 25% more against deposits than industry standards for maximum performance and engine longevity. And with an exceptional range of temperature protection your engine will ready for extreme weather. Valvoline invented motor oil 150 years ago, and we’ve been reinventing it ever since. Get Valvoline Advanced Full Synthetic and give your engine the advanced protection proven to maximize engine life.

Product Features:
  • ADVANCED PROTECTION AGAINST the four main causes of engine breakdown: wear friction heat and deposits
  • 40% BETTER WEAR PROTECTION vs. industry standard as tested in the Sequence IVB engine test
  • 25% BETTER DEPOSIT PROTECTION with superior engine cleaning detergents as tested in the GMOD engine test
  • EXCEPTIONAL HIGH/LOW TEMPERATURE PROTECTION defends your motor no matter the weather conditions
  • MEETS OR EXCEEDS ALL REQUIREMENTS of ILSAC GF-6A, API SP, API SN with SN PLUS, API SN, GM dexos 1 Gen 3
  • Enhanced Oil Stability: Resists oil breakdown 10-times better than industry standards, providing consistent performance and reliability.
  • Premium Additives: Contains premium anti-wear additives, superior antioxidants, and extra detergents for maximum performance and engine longevity.
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Valvoline – MaxLife 5W-30 Synthetic Blend Motor Oil, Prevents Engine Breakdown, 1 Quart (Part No.VV1556)

MaxLife 5W-30 Synthetic Blend Motor Oil, Prevents Engine Breakdown, 1 Quart

from

$8.29
75,000 miles is more than a mile marker. It’s a signal that your engine is ready for greater protection. That’s when you need Valvoline High Mileage with MaxLife Technology Motor Oil. Its exclusive formula is proven to maximize engine life in cars, trucks, and SUVs with over 75,000 miles. Our mixture is specially developed with a unique combination of synthetic and premium conventional oils to protect your high-mileage motor against wear, friction, heat, and deposits – the four major causes of engine breakdown and expensive repairs. Anti-wear additives defend critical engine components, advanced friction-fighting agents reduce heat and abrasion, added detergents clean the inside of your engine, and premium seal conditioners handle aging seals to prevent leaks. It fights sludge, corrosion and rust that can rob your engine of horsepower, fuel efficiency & longevity. From extreme temperatures and cold starts to stop-and-go traffic and frequent short trips, viscosity modifiers make sure the oil flows more easily, coats more completely, and resists thermal breakdown under even the most intense driving conditions. Its unique mixture curbs contaminants to keep high-mileage engines from burning and consuming oil that can foul spark plugs, creating higher emissions and causing your motor to run roughly.

Product Features:
  • MAXLIFE TECHNOLOGY PREVENTS engine breakdown with 40% better wear protection than the industry standard.
  • REFRESH AGING SEALS AND PREVENT LEAKS with seal conditioners
  • REDUCE SLUDGE, DEPOSITS, CORROSION, AND RUST with added detergents – keep motors clean inside
  • ENHANCED FRICTION PERFORMANCE HELPS MAXIMIZE POWER with advanced friction-fighting agents
  • MEETS OR EXCEEDS ALL REQUIREMENTS of ILSAC GF-6A, API SP, API SN with SN PLUS, API SN
  • MaxLife Technology: Valvoline High Mileage with MaxLife Technology is specially formulated to maximize engine life in vehicles with over 75,000 miles, providing superior protection against wear, friction, heat, and deposits.
  • Synthetic Blend Composition: This motor oil features a unique combination of synthetic and premium conventional oils, ensuring optimal performance and protection for high-mileage engines.
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Mobil 1 – Full Synthetic ATF: Automatic Transmission Fluid, Outperforms Conventional ATFs, 1 Quart (Part No.25201)

Full Synthetic ATF: Automatic Transmission Fluid, Outperforms Conventional ATFs, 1 Quart

from

$11.99
Mobil 1 Synthetic ATF is a multi-vehicle, fully synthetic automatic transmission fluid that helps to improve overall transmission durability and cleanliness. Has exceptional thermal and oxidation stability and long-term frictional properties that help to improve and extend transmission efficiency, smooth shifting performance, and fuel economy. Mobil 1 ATF provides excellent low-temperature fluidity to promote reliable lubrication at temperatures down to -51C, and exceptional shear stability to help supports viscosity retention under the most severe heavy-duty, high-temperature operating conditions. Compatible with mineral ATF fluids and all common seal materials to help provide excellent leakage control and reduce concern in top-off emergencies. Meets or exceeds the requirements of JASO 1-A and Ford MERCON V. For more information, visit us at Mobil.US.

Product Features:
  • Mobil 1 Synthetic ATF is a multi-vehicle automatic transmission fluid that helps to improve overall transmission durability and cleanliness
  • Exceptional thermal and oxidation stability to improve and extend transmission efficiency, smooth shifting performance, and fuel economy
  • Excellent high and low-temperature fluidity to help support viscosity retention under extreme, heavy-duty operating conditions
  • Compatible with mineral ATF fluids and all common seal materials to help provide excellent leakage control
  • Meets or exceeds the requirements of JASO 1-A and Ford MERCON V
  • Manufacturer Part Number: 112980
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FRAM – FRAM Full Synthetic Dexron VI Automatic Transmission Fluid, 1 Gallon (Part No.F426-1G)

FRAM Full Synthetic Dexron VI Automatic Transmission Fluid, 1 Gallon

from

$32.99
FRAM DEXRON-VI FULL SYNTHETIC ATF represents the latest technology in full synthetic automatic transmission fluids. This product is designed for the newest generation of highly efficient transmissions now being installed in most vehicles, and is DEXRON-VI licensed by GM and meets JASO 1A performance requirements. It is a fuel efficient choice for older models as well, such as those currently using DEXRON-III. FRAM DEXRON-VI FULL SYNTHETIC ATF is recommended for use in all GM DEXRON applications and in transmissions applications calling for Toyota WS, Nissan  Matic J and Matic S, Ford part numbers XT-10-QLV and XT-6-QSP, Honda Z-1 and DW 1, and Hyundai SP-VI. Check owner’s manual for specific recommendations.

Product Features:
  • Outstanding resistance to oxidative and thermal breakdown.
  • Exceptional low temperature fluidity.
  • Excellent anti-wear properties.
  • Excellent gear shift quality throughout service life.
  • Always Refer To Your Vehicles Operating Manual To Select The Correct Grade Fluid For Your Transmission
  • Transmission Fluids Also Applicable In Power Steering Units; Check Owners’ Manual
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Pentosin – Pentosin Atf 1 Lv 5L (Part No.1088206)

Pentosin Atf 1 Lv 5L

from

$55.99
Pentosin ATF 1 LV Automatic Transmission Fluid is suitable for all MB 5

Product Features:
  • Formulated anti-wear chemistry and friction modifiers guarantee stable friction performance in modern transmissions.
  • ATF 1 surpasses all Dexron III quality level requirements.
  • Meets ZF TE 11B specification standards.
  • A fully synthetic high performance ATF for life-time application in automatic gear boxes.
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ATP – Auto Trans Fluid (Part No.AT-216)

Auto Trans Fluid

from

$23.49
Product Features:
  • Fully Synthetic
  • Advance transmission protection from standard to sever duty
  • Resist thermal breakdown, oxidation, varnish and sludge
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FRAM – FRAM Full Synthetic Dexron VI Automatic Transmission Fluid, 1 Quart (Part No.F426)

FRAM Full Synthetic Dexron VI Automatic Transmission Fluid, 1 Quart

from

$11.99
FRAM DEXRON-VI FULL SYNTHETIC ATF represents the latest technology in full synthetic automatic transmission fluids. This product is designed for the newest generation of highly efficient transmissions now being installed in most vehicles, and is DEXRON-VI licensed by GM and meets JASO 1A performance requirements. It is a fuel efficient choice for older models as well, such as those currently using DEXRON-III. FRAM DEXRON-VI FULL SYNTHETIC ATF is recommended for use in all GM DEXRON applications and in transmissions applications calling for Toyota WS, Nissan  Matic J and Matic S, Ford part numbers XT-10-QLV and XT-6-QSP, Honda Z-1 and DW 1, and Hyundai SP-VI. Check owner’s manual for specific recommendations.

Product Features:
  • Outstanding resistance to oxidative and thermal breakdown.
  • Exceptional low temperature fluidity.
  • Excellent anti-wear properties.
  • Excellent gear shift quality throughout service life.
  • Always Refer To Your Vehicles Operating Manual To Select The Correct Grade Fluid For Your Transmission
  • Transmission Fluids Also Applicable In Power Steering Units; Check Owners’ Manual
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Transmission Fluids Brands You Can Trust For Your Lexus IS350

6 trusted brands of Transmission Fluids line our shelves, ready to help keep your Lexus IS350 running smooth. Below are some of the most popular brands and their top Transmission Fluids offerings:

Top Lexus IS350 Transmission Fluids from Valvoline

Your Lexus IS350 will be purring again thanks to Valvoline brand Transmission Fluids available for online order or in-store pick up. Popular Valvoline parts include:

Most Purchased Lexus IS350 Transmission Fluids from Mobil 1

When you buy the most frequently purchased Mobil 1 brand Transmission Fluids, you can be confident it will be the right part for your Lexus IS350. Here are the Mobil 1 Transmission Fluids Advanced Auto customers buy the most:
Advanced Full Synthetic Engine Oil 5W-30, Extends Engine Life, 5 Quart
from $37.99
(1809)
Advanced Full Synthetic Engine Oil 5W-30, Extends Engine Life, 5 Quart
Manual Transmission Fluids
FRAM Full Synthetic Dexron VI Automatic Transmission Fluid, 1 Gallon
from $32.99
This product is not rated
FRAM Full Synthetic Dexron VI Automatic Transmission Fluid, 1 Gallon
Automatic Transmission Fluids

FAQs for Lexus IS350 Transmission Fluids

What are the most purchased Transmission Fluids for the Lexus IS350?

Out of 19 Transmission Fluids for the Lexus IS350, the most popular in our inventory are:
Advanced Full Synthetic Engine Oil 5W-30, Extends Engine Life, 5 Quart
from $37.99
(1809)
Advanced Full Synthetic Engine Oil 5W-30, Extends Engine Life, 5 Quart
Manual Transmission Fluids
FRAM Full Synthetic Dexron VI Automatic Transmission Fluid, 1 Gallon
from $32.99
This product is not rated
FRAM Full Synthetic Dexron VI Automatic Transmission Fluid, 1 Gallon
Automatic Transmission Fluids
FRAM Full Synthetic Dexron VI Automatic Transmission Fluid, 1 Quart
from $11.99
This product is not rated
FRAM Full Synthetic Dexron VI Automatic Transmission Fluid, 1 Quart
Automatic Transmission Fluids

What are the top-rated Lexus IS350 Transmission Fluids?

Top-rated Transmission Fluids for your Lexus IS350 based on customer reviews/ratings are:
Full Synthetic ATF: Automatic Transmission Fluid, Outperforms Conventional ATFs, 1 Quart
from $11.99
(58)
Full Synthetic ATF: Automatic Transmission Fluid, Outperforms Conventional ATFs, 1 Quart
“I changed out my Audi factory fluid at 80K miles. I know have 170 K with Mobil 1 ATF. Audi wanted to use their fluid but have had great success with M”