2022 Lexus ES350 Cooling and Climate Controls

Essential Cooling and Climate Controls for 2022 Lexus ES350s

DENSO – First Time Fit A/C Conr (Part No.R1030384972ND)

First Time Fit A/C Conr

from

$209.98
Like all DENSO First Time Fit® A/C components, our condensers are designed and manufactured to integrate seamlessly with the vehicle’s original air conditioning system. DENSO condensers match up to OE condensers at every benchmark. Multiflow, subcooling, and the latest Ssrpentine condenser styles are offered to provide the optimum configuration for each application. Premium aluminum construction improves reliability, resisting corrosion to avoid expensive system leaks, while the superior fin wave design offers higher heat transfer and maximum refrigerant condensation. Heat exchanger cores are specially designed to shed airborne material buildup, allowing the A/C system to operate at peak efficiency with minimal maintenance, assuring years of trouble-free service.

Product Features:
  • Zinc diffusion layer improves corrosion resistance
  • Unique fin design to minimize airflow blockage
  • High performance design reduces the required compressor power
  • System Efficiency: Superior fin waves provide a higher heat transfer coefficient and full condensation.
  • Engineered to Perfection: OE quality engineered for unparalleled performance
  • Exact Fit: Condensers install with speed and ease
  • Reduces required compressor power, resulting improved fuel economy
  • Restores A/C performance to as-new condition
  • First Time Fit® assures bolt-in replacement; no brackets or adapters
  • Greater Durability: Pure aluminum construction provides greater resistance for corrosion
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KAI – A/C Condenser (Part No.CND4244)

A/C Condenser

from

$77.99
New Platinum Pro A/C Condenser, ES350 13-15 All/ES350 16-18 Japan Built Models Only

Product Features:
  • ES350 13-15 All/ES350 16-18 Japan Built Models Only, Made Of Aluminum
  • Meets All Federal Motor Safety Standards
  • No Drilling Needed For Installation
  • No Modifications Needed For Installation
  • Direct Fit Replacement For Your Vehicle
  • Same Form Fit And Function As OE
  • Check Out The Large Selection Of Parts Available For Your Vehicle
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Carquest Premium – Engine Water Pump: New, Gasket/Seals Included (Part No.T3130)

Engine Water Pump: New, Gasket/Seals Included

from

$134.99
Carquest Premium drive motor inverter cooler water pumps are 100% new, high-quality parts that meet or exceed original equipment (O.E.) specifications. All components, including the housing, impeller, controller, gaskets, and seals are designed for long-lasting service life. These electric water pumps are supplied with the gaskets or seals necessary for installation. Our Carquest Premium auxiliary water pumps undergo stringent testing to ensure superior performance that we stand behind with an industry-leading warranty.

Product Features:
  • Built to meet or exceed OE fit, form and function
  • All components necessary for installation are supplied with pump
  • 100% tested for reliable performance
  • Follow all enclosed instructions to maximize pump life and validate warranty
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NPW – Water Pump (Part No.G3000848775NPW)

Water Pump

from

$137.16
Water Pump

Carquest Premium – Radiator: With Transmission Oil Cooler (Part No.812919)

Radiator: With Transmission Oil Cooler

from

$271.99
Carquest Premium radiators are designed and engineered for maximum performance, using the highest-grade materials to ensure all radiators meet or exceed original equipment (O.E.) fit, form and function. Carquest Premium radiators are built by manufacturers that meet IATF 16949 certified framework, an internationally recognized proof of quality in the automotive industry. Most modern vehicles use radiators with plastic tanks and our parts are engineered with integrated ribbing to prevent damage during thermal cycling. Carquest Premium radiators are also 100% tested to ensure a durable, leak-free cooling system repair.

Product Features:
  • Thermal tested under real-life temperature simulations
  • High tensile strength aluminum for maximum crimp strength
  • Plastic tanks are engineered with integrated ribbing for added strength to withstand cracks, bowing and distortion during thermal cycles
  • Thermal expansion slots extend core life and reduce failure rates by allowing improved core expansion and contraction during systematic heat cycles
  • Oil cooler designs meet or exceed OE standards, keeping the vehicle¿s engine and transmission performing at optimal conditions
  • OEM grade, premium fittings for transmission or engine oil coolers (where applicable)
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DENSO – Radiator (Part No.G1000232753ND)

Radiator

from

$283.08
Radiator

Carquest Premium – Ambient Air Temperature Sensor (Part No.WTA1121)

Ambient Air Temperature Sensor

from

$43.99
CARQUEST premium engine management products provide the right products for a wide range of domestic and import applications. Delivering the highest performance and durability under demanding conditions.
See More

Carquest Premium – Coolant Temperature Sensor with O-Ring (Part No.WTC2071)

Coolant Temperature Sensor with O-Ring

from

$8.99
Approved materials for increased durability in even the most extreme temperatures. All MotoRad Coolant Temperature Sensors are designed to meet or exceed OEM specifications at our ISO TS16949 manufacturing facilities.

Product Features:
  • 100% factory resistance calibrated to ensure precision tolerances, resulting in extremely accurate temperature for optimal performance
  • Thread Sealant and/or O-ring pre-installed on applicable sensors to ensure leak free performance
  • Brass sensor housing precision machined to meet or exceed OE thermal conductivity
  • OE precision matched thermistor position for correct output parameters
  • Extensive product testing includes salt spray, high/low temperature impact, thermal vibration, durability, static electricity, and micro tension, among other tests, to ensure all sensors meet or exceed OEM specifications.
See More

Sankei Switches – Engine Coolant Temperature Sensor (Part No.C6020243726SAK)

Engine Coolant Temperature Sensor

from

$33.13
The Sankei Switches Engine Coolant Temperature Sensor is a high quality Original Equipment replacement that is manufactured to meet or exceed OE specifications for fit, form, and function.

Product Features:
  • Premium Original Equipment replacement
  • Provides performance and dependability
  • Manufactured to meet OE specifications
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Carquest Premium – OUTLET FLANGE (Part No.CH2093)

OUTLET FLANGE

from

$74.99
OUTLET FLANGE

Sankei Switches – Sankei Switches Radiator Cap (Part No.G101045813SAK)

Sankei Switches Radiator Cap

from

$11.27
The Sankei Switches radiator cap range has been developed to operate within original equipment manufacturer’s specifications. A faulty radiator cap can cause your car to boil-over at a lower temperature. Test or replace the coolant cap when servicing the cooling system.

Product Features:
  • Meets Original Equipment specifications.
  • Made from premium materials.
  • Designed to function on open cooling systems and overflow reservoir type systems.
See More

Carquest Premium – Radiator Cap: 16 PSI (Part No.10242)

Radiator Cap: 16 PSI

from

$14.99
Crafted to meet the exact specifications set by Original Equipment Manufacturers (OEM), these products are engineered for effortless installation and removal. Constructed from premium-grade components, incorporating proper relief and vacuum valves, they ensure optimal performance even in the most demanding automotive cooling systems. Rigorously quality-tested, these components provide exceptional, out-of-the-box performance and superior durability to meet or exceed the highest standards of today’s vehicles.

Product Features:
  • Maintains proper cooling system pressure
  • Easy installation and removal
  • 100% tested to ensure proper pressure and longevity
  • Meets all OEM specifications
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Carquest Premium – COOLANT HOUSING (Part No.CH2096)

COOLANT HOUSING

from

$60.99
COOLANT HOUSING

Carquest Premium – Blower Motor: With Wheel (Part No.76500)

Blower Motor: With Wheel

from

$152.99
Carquest Premium Blower Motors are engineered and tested to provide years of trouble free operation. Backed by over 50 years of mobile A/C experience, fix it once and fix it right with Carquest Premium Blower Motors. Meets or exceeds OE design. Magnetic size and properties compare or exceed OEM. Windings meet or exceed OEM Specifications. Motor RPM equivalent to or exceeds OEM motor.

Product Features:
  • Meets or exceeds OE design and performance
  • Magnetic size and properties compare or exceed OEM
  • Windings meet or exceed OEM specifications
  • Motor RPM equivalent to or exceeds OEM motor
  • Functionally Equivalent to OE Design
  • Each unit is 100% tested for functional performance and operational noise
  • Hermetically Sealed & Thermally Protected Electronics
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Carquest Premium – Blower Motor: With Wheel (Part No.75830)

Blower Motor: With Wheel

from

$144.99
Carquest Premium Blower Motors are engineered and tested to provide years of trouble free operation. Backed by over 50 years of mobile A/C experience, fix it once and fix it right with Carquest Premium Blower Motors. Meets or exceeds OE design. Magnetic size and properties compare or exceed OEM. Windings meet or exceed OEM Specifications. Motor RPM equivalent to or exceeds OEM motor.

Product Features:
  • Meets or exceeds OE design and performance
  • Magnetic size and properties compare or exceed OEM
  • Windings meet or exceed OEM specifications
  • Motor RPM equivalent to or exceeds OEM motor
See More

Carquest Premium – Blower Motor: With Wheel (Part No.76513)

Blower Motor: With Wheel

from

$304.99
Carquest Premium Blower Motors are engineered and tested to provide years of trouble free operation. Backed by over 50 years of mobile A/C experience, fix it once and fix it right with Carquest Premium Blower Motors. Meets or exceeds OE design. Magnetic size and properties compare or exceed OEM. Windings meet or exceed OEM Specifications. Motor RPM equivalent to or exceeds OEM motor.

Product Features:
  • Meets or exceeds OE design and performance
  • Magnetic size and properties compare or exceed OEM
  • Windings meet or exceed OEM specifications
  • Motor RPM equivalent to or exceeds OEM motor
  • Functionally Equivalent to OE Design
  • Magnetic size and properties compare or exceed OEM
  • Hermetically Sealed & Thermally Protected Electronics
See More

Dorman – Coolant Housing/Water Outlet: With Housing, 50 Degree Neck Angle (Part No.902-5932)

Coolant Housing/Water Outlet: With Housing, 50 Degree Neck Angle

from

$38.49
This replacement engine coolant thermostat housing is engineered to match the fit and durability of the stock thermostat housing on specified vehicles. It is designed to withstand extreme temperature changes to extend service life.

Product Features:
  • Ideal replacement – this engine coolant thermostat housing directly replaces the original housing on specified vehicle years, makes and models.
  • Durable construction – this part is specifically designed to withstand extreme temperature changes and resist cracking and leaking.
  • Cost-effective and reliable – offers original manufacturer quality at lower cost than getting replacement at dealer
  • Industry-leading design – professionally engineered by the aftermarket leader in replacement thermostat housings
See More

Carquest Premium – New Compressor (Part No.T168367)

New Compressor

from

$462.99
Carquest Premium A/C compressors are 100% new units that are manufactured to the highest quality to meet or exceed OE specifications.

Product Features:
  • Every unit is 100% function and leak tested
  • Tested for noise, vibration, durability, vacuum decay and pressure decay to ensure no leaks and longer life
  • Very low friction coating used on swash plate to improve durability
  • PTFE coated pistons improve performance and reduce wear
  • Rubber dampened clutch plate ensures smooth clutch engagement and reduces wear
  • Matched high-quality needle-roller bearing ensures low friction and high load capability
  • Limited Lifetime Warranty when following warranty requirements: Flush A/C System, replace accumulator/receiver dryer, replace orifice tube/expansion device, and filling with correct oil and refrigerant
See More

DENSO – First Time Fit Relay (Part No.P2020194560ND)

First Time Fit Relay

from

$25.84
An electrical relay is sort of a magical device: it takes a small electrical signal and uses it to manage a much more powerful current, permitting electrical systems to be both lighter and more dependable at the same time. DENSO has supplied quality relays to the OE automotive world for over 60 years. The very same performance and dependability are available across the replacement aftermarket with DENSO First Time Fit® relays. Engineered to meet the most stringent automaker standards for shock resistance, arcing, and thermal protection, DENSO auto relays feature the lowest return rates in the industry; that equals value for car owners and repair facilities alike

Product Features:
  • Lead-free, solderless construction prevents heat shock and arcing
  • Controlled contact force, self-adjusting air gap increase longevity of the internal parts
  • Industry-standard packaging and footprint
  • Low heat generation
  • Reduced electrical loads
  • Built to last
See More

Carquest Premium – Multi Purpose Relay (Part No.RAA2117)

Multi Purpose Relay

from

$17.79
Carquest premium engine management products provide the right products for a wide range of domestic and import applications. Delivering the highest performance and durability under demanding conditions.
See More

Upgrade your 2022 Lexus ES350 with Top-Quality Cooling and Climate Controls

When it comes to maintaining or upgrading your 2022 Lexus ES350, nothing is more important than using high-quality OEM or aftermarket parts that you can trust. Whether you’re repairing damage to your Lexus or enhancing its overall performance, Cooling and Climate Controls are key to keeping your ES350 functioning at its best. At Advance Auto Parts, we offer a wide selection of 12 Cooling and Climate Controls for the 2022 Lexus ES350, designed to meet your needs without breaking the bank. From Air Conditioning Part replacements to HVAC Electrical Parts upgrades, we’ve got you covered with parts that fit your vehicle perfectly and ensure long-lasting performance.

Affordable Prices and Wide Selection

Shopping for Cooling and Climate Controls for any vehicle can be a hassle, especially if you’re on a budget. But with Advance Auto Parts, you can find high-quality Cooling and Climate Controls for your 2022 Lexus ES350 at great prices. Our Cooling and Climate Controls inventory for this model ranges from just $8.99 to $462.99, with an average price of $127.77. Our 12 Cooling and Climate Controls in stock come from 7 trusted brands, so you’re sure to find the right part for your 2022 Lexus ES350 without overspending.

Explore Related Parts and More

While you’re here, don’t forget to check out other essential categories that go hand in hand with Cooling and Climate Control upgrades. Explore related part types like Batteries and Chargers, Oil and Lubricants and more to make sure your 2022 Lexus ES350 is always ready to roll. We’re committed to providing you with everything you need to keep your ES350 in top shape, all in one place. Start shopping confidently below for your 2022 Lexus ES350!

Best-Selling Air Conditioning Parts for 2022 Lexus ES350s

Enhance the driving experience in your Lexus with 2 quality Air Conditioning Part components, starting at $134.64.

Carquest Premium – New Compressor (Part No.T168367)

New Compressor

from

$462.99
Carquest Premium A/C compressors are 100% new units that are manufactured to the highest quality to meet or exceed OE specifications.

Product Features:
  • Every unit is 100% function and leak tested
  • Tested for noise, vibration, durability, vacuum decay and pressure decay to ensure no leaks and longer life
  • Very low friction coating used on swash plate to improve durability
  • PTFE coated pistons improve performance and reduce wear
  • Rubber dampened clutch plate ensures smooth clutch engagement and reduces wear
  • Matched high-quality needle-roller bearing ensures low friction and high load capability
  • Limited Lifetime Warranty when following warranty requirements: Flush A/C System, replace accumulator/receiver dryer, replace orifice tube/expansion device, and filling with correct oil and refrigerant
See More

Koyo Cooling – A/C Condenser (Part No.R10301364793KCS)

A/C Condenser

from

$134.64
A/C Condenser

Most Popular 2022 Lexus ES350 HVAC Electrical Parts

Customize your Lexus with 1 HVAC Electrical Parts products like Cabin Air Temperature Sensors, all priced under $32.81.

DENSO – Cabin Air Temperatur (Part No.P4028815518ND)

Cabin Air Temperatur

from

$32.81
Cabin Air Temperatur

Top Picks for 2022 Lexus ES350 Engine Cooling Parts

Upgrade Lexus ES350s with top-quality Engine Cooling Parts parts, including 8 OEM and aftermarket selections for your 2022 model.

Sankei Switches – Sankei Switches Radiator Cap (Part No.G101045813SAK)

Sankei Switches Radiator Cap

from

$11.27
The Sankei Switches radiator cap range has been developed to operate within original equipment manufacturer’s specifications. A faulty radiator cap can cause your car to boil-over at a lower temperature. Test or replace the coolant cap when servicing the cooling system.

Product Features:
  • Meets Original Equipment specifications.
  • Made from premium materials.
  • Designed to function on open cooling systems and overflow reservoir type systems.
See More

DENSO – First Time Fit Relay (Part No.P2020194560ND)

First Time Fit Relay

from

$25.84
An electrical relay is sort of a magical device: it takes a small electrical signal and uses it to manage a much more powerful current, permitting electrical systems to be both lighter and more dependable at the same time. DENSO has supplied quality relays to the OE automotive world for over 60 years. The very same performance and dependability are available across the replacement aftermarket with DENSO First Time Fit® relays. Engineered to meet the most stringent automaker standards for shock resistance, arcing, and thermal protection, DENSO auto relays feature the lowest return rates in the industry; that equals value for car owners and repair facilities alike

Product Features:
  • Lead-free, solderless construction prevents heat shock and arcing
  • Controlled contact force, self-adjusting air gap increase longevity of the internal parts
  • Industry-standard packaging and footprint
  • Low heat generation
  • Reduced electrical loads
  • Built to last
See More

Autopart International Inc – RADIATOR (Part No.G10003129218API)

RADIATOR

from

$242.52
RADIATOR

Aisan – Water Pump (Part No.G3000838456ASC)

Water Pump

from

$134.77
Water Pump

Carquest Premium – OUTLET FLANGE (Part No.CH2093)

OUTLET FLANGE

from

$74.99
OUTLET FLANGE

Carquest Premium – COOLANT HOUSING (Part No.CH2096)

COOLANT HOUSING

from

$60.99
COOLANT HOUSING

Dorman – Coolant Housing/Water Outlet: With Housing, 50 Degree Neck Angle (Part No.902-5932)

Coolant Housing/Water Outlet: With Housing, 50 Degree Neck Angle

from

$38.49
This replacement engine coolant thermostat housing is engineered to match the fit and durability of the stock thermostat housing on specified vehicles. It is designed to withstand extreme temperature changes to extend service life.

Product Features:
  • Ideal replacement – this engine coolant thermostat housing directly replaces the original housing on specified vehicle years, makes and models.
  • Durable construction – this part is specifically designed to withstand extreme temperature changes and resist cracking and leaking.
  • Cost-effective and reliable – offers original manufacturer quality at lower cost than getting replacement at dealer
  • Industry-leading design – professionally engineered by the aftermarket leader in replacement thermostat housings
See More

Carquest Premium – Coolant Temperature Sensor with O-Ring (Part No.WTC2071)

Coolant Temperature Sensor with O-Ring

from

$8.99
Approved materials for increased durability in even the most extreme temperatures. All MotoRad Coolant Temperature Sensors are designed to meet or exceed OEM specifications at our ISO TS16949 manufacturing facilities.

Product Features:
  • 100% factory resistance calibrated to ensure precision tolerances, resulting in extremely accurate temperature for optimal performance
  • Thread Sealant and/or O-ring pre-installed on applicable sensors to ensure leak free performance
  • Brass sensor housing precision machined to meet or exceed OE thermal conductivity
  • OE precision matched thermistor position for correct output parameters
  • Extensive product testing includes salt spray, high/low temperature impact, thermal vibration, durability, static electricity, and micro tension, among other tests, to ensure all sensors meet or exceed OEM specifications.
See More

In-Demand Blower Motor and Related Products for 2022 Lexus ES350s

Select from 1 premium Blower Motor and Related Products parts for your 2022 Lexus ES350.

Carquest Premium – Blower Motor: With Wheel (Part No.76513)

Blower Motor: With Wheel

from

$304.99
Carquest Premium Blower Motors are engineered and tested to provide years of trouble free operation. Backed by over 50 years of mobile A/C experience, fix it once and fix it right with Carquest Premium Blower Motors. Meets or exceeds OE design. Magnetic size and properties compare or exceed OEM. Windings meet or exceed OEM Specifications. Motor RPM equivalent to or exceeds OEM motor.

Product Features:
  • Meets or exceeds OE design and performance
  • Magnetic size and properties compare or exceed OEM
  • Windings meet or exceed OEM specifications
  • Motor RPM equivalent to or exceeds OEM motor
  • Functionally Equivalent to OE Design
  • Magnetic size and properties compare or exceed OEM
  • Hermetically Sealed & Thermally Protected Electronics
See More

FAQs for 2022 Lexus ES350 Cooling and Climate Controls

Which Cooling and Climate Controls are best-sellers for 2022 Lexus ES350s?

Out of 12 Cooling and Climate Controls that fit 2022 Lexus ES350s, the following parts are the top sellers:

What’s the price range for 2022 Lexus ES350 Cooling and Climate Controls?

Cooling and Climate Control prices for the 2022 Lexus ES350 start at $8.99 and go up to $462.99 for the most premium parts.

What’s the average price of a Cooling and Climate Control for a 2022 Lexus ES350?

The average price for Cooling and Climate Controls for the 2022 Lexus ES350 is $127.77. Keep in mind the variety of part types within our Cooling and Climate Control category so you are likely to find a wide range of prices across a variety of parts and components.

Does Advance Auto Parts sell Cooling and Climate Controls for other Lexus ES350 model years?

Yes, we currently carry Cooling and Climate Controls for 17 model years of Lexus ES350s between 2007 and 2024. Cooling and Climate Controls are bought most frequently for the following model years: 2023, 2021, 2020, 2019, 2018, 2017, 2016, 2015, and 2014.

What are the cheapest Cooling and Climate Controls for my 2022 Lexus ES350?

The cheapest 2022 Lexus ES350 Cooling and Climate Controls we carry in stock are:

What are the top-rated Cooling and Climate Controls that fit the 2022 Lexus ES350?

Out of 1 reviews by customers, our 2022 Lexus ES350 Cooling and Climate Controls have an average customer rating of . These are some of the highest-rated Cooling and Climate Control types for the 2022 Lexus ES350 and their top-rated products:

What types of Cooling and Climate Controls do you sell for my 2022 Lexus ES350?

As of 2/5/25, these are some of the most in-demand types of Cooling and Climate Controls for a 2022 Lexus ES350:

Can I get help with 2022 Lexus ES350 Cooling and Climate Control orders?

Contact our customer support team, by chat or phone, through the help desk page, where you can find instant answers about Lexus Cooling and Climate Controls and more.

What is your return policy for Lexus ES350 Cooling and Climate Controls?

Advance Auto Parts keeps returns simple. For new Lexus ES350 Cooling and Climate Controls and accessories, your online orders can be returned, in their original condition, within 45 days. For requirements, see the returns page.