2022 Lexus ES250 Drivetrains
Find Your Specific 2022 Lexus ES250 Drivetrains
Below you will find various in-demand Lexus Drivetrains, components and accessories for your 2022 ES250. Advance Auto Parts has popular ES250 parts like Spindles, Differentials, Drive Shafts and Axles and more. You’ll also find aftermarket and OEM Drivetrains for other ES250 model years including
1990,
1991,
2021,
2023,
2024,
2025 and more. Select a category of 2022 Lexus ES250 Drivetrains below and start saving instantly.
Popular 2022 Lexus ES250 Drivetrains Categories
Essential Drivetrains for 2022 Lexus ES250s
National – Drive Axle Shaft Seal (Part No.711096)
from
$11.49
National has built a reputation as one of the most respected names in the industry. We have offered premium sealing solutions for more than 75 years. Our design team keeps pace with the industry and provides advanced solutions for today’s vehicles.
Product Features:
See More
Product Features:
- Design type: spring loaded; multi-lip
- Temperature range: -20 Deg. F to 300 Deg. F / -29 Deg. C to 49 Deg. C
- Resistance to EP lubricants
- Low swell in hydrocarbon fluids
- Delivers quality and reliable performance for every type of repair
Dorman – Standard Spindle Nut M19-1.5 Hex Size 30mm (Part No.615-109.1)
from
$10.49
This spindle nut is designed to match the fit and function of the original part on specified vehicles. Made of quality materials, it is engineered for reliable performance.
Product Features:
See More
Product Features:
- Direct replacement – this spindle nut matches the fit and function of the factory part on specified years, makes and models
- Ideal solution – this nut is a reliable replacement for an original part that is missing or has failed due to fatigue
- Durable construction – this part is made from quality materials to ensure reliable performance and long service life
- Trustworthy quality – backed by team of product experts in the United States and more than a century of automotive experience
Dorman – Spindle Nut M22-1.50 Hex Star Pattern (sold by each) (Part No.615-224)
from
$10.99
This spindle nut is designed to match the fit and function of the original part on specified vehicles. Made of quality materials, it is engineered for reliable performance.
Product Features:
See More
Product Features:
- Direct replacement – this spindle nut matches the fit and function of the factory part on specified years, makes and models
- Ideal solution – this nut is a reliable replacement for an original part that is missing or has failed due to fatigue
- Durable construction – this part is made from quality materials to ensure reliable performance and long service life
- Trustworthy quality – backed by team of product experts in the United States and more than a century of automotive experience
Valvoline – Flex Fill Transmission & Differential Gear Oil: Full Synthetic 75W-90, 1 Quart (Part No.889785)
from
$18.99
We’ve squeezed innovation into every ounce of Valvoline FlexFill SAE 75W-90 Full Synthetic Gear Oil, the ultimate gear protection in hypoid rear differentials and non-synchronized manual transmissions. Our unique new flexible pouch makes getting into the tightest places to lubricate gears easier than ever and with less waste. The superior detergent package-based formulation contains fully synthetic basestocks and special additives that help protect parts from rust and corrosion while providing exceptional high and low temperature protection and excellent thermal stability, especially in demanding driving situations such as towing and off-roading. It contains an extreme pressure additive for better load carrying capacity, wear resistance additives that assist in protecting gear teeth, a limited slip additive for optimal clutch pack performance, and an anti-foaming agent for better lubrication and service life. Valvoline FlexFill SAE 75W-90 Full Synthetic Gear Oil is recommended for use in axle applications requiring factory-fill or drain-and-fill levels for limited slip performance.
Product Features:
See More
Product Features:
- FLEXIBLE POUCH FOR EASIER USE WITH LESS WASTE in tight, hard to reach undercarriage situations.
- EXCEPTIONAL HIGH AND LOW TEMPERATURE PROTECTION ranging from -30F to 300F degrees for dependable coverage year-round
- REDUCES CHATTERING AND PROTECTS GEAR TEETH from oxidation, rust, and wear
- MEETS THE DEMANDS OF CONVENTIONAL AND LIMITED SLIP REAR DIFFERENTIALS where API GL-5 is specified, as well as non-synchronized manual transmissions that require API GL-4 or MT-1 fluid
- MEETS OR EXCEEDS PERFORMANCE REQUIREMENTS for Mack GO-H and GO-J; API GL-5 and API MT-1; MIL-PRF-2105E; and SAE J2360
Valvoline – DEX/MERC ATF Conventional Automatic Transmission Fluid, 1 Quart (Part No.798153)
from
$11.99
Valvoline DEX/MERC ATF is a high-quality transmission fluid formulated to meet the challenging demands of many automatic transmissions. Its responsive low-temperature fluidity is beneficial in both electronic and hydraulic controlled transmissions and transaxles. Recommended for use in the following applications: MERCON*, DEXRON*-III, Ford M2C138-CJ and M2C166-H, Allison C-4 and TES-389, and Caterpillar TO-2.
Product Features:
See More
Product Features:
- Formulated with premium base stocks and advanced additive technology to meet the challenging demands of automatic transmissions
- Enhanced anti-shudder protection for smooth shifting and maximum power transfer
- Developed with anti-wear technology to help improve transmission durability
- Engineered with a proprietary blend of base oils and advanced additives to provide better oil flow at low temperatures and greater film protection at higher temperatures
Royal Purple – High Performance 5W-30 Synthetic Engine Oil, Better Wear Protection, 5 Quart (Part No.51530)
from
$41.99
Royal Purple Motor Oil is a specially formulated multi viscocity oil for use in gasoline and diesel engines of all types from cars and trucks to SUVs, motorcycles and boats. Royal Purple(R) Motor Oil with Synerlec(R) additive technology reduces friction, which results in a 1-3 percent increase in horsepower, lowers operating temperatures, provides superior corrosion protection, improves fuel economy, reduces emissions and extends oil life. A.P.I. Certified.
Product Features:
See More
Product Features:
- Better wear protection
- Increased fuel efficiency
- Better protection of the expensive catalytic emission system
- Improved compatibility with fuels containing ethanol
- Superior corrosion protection
- Meets ILSAC GF-5 and Dexos1 performance requirements
Idemitsu – Type TLS-LV Automatic Transmission Fluid, 1 Quart (Part No.30040096-75000C)
from
$14.49
Formulated to meet the specific requirements of Toyota, Lexus, and Scion vehicles equipped with conventional (non-CVT) transmissions that require the use of Toyota ATF WS. Recommended for service-fill in all Toyota, Lexus, and Scion automatic transmissions where ATF WS is specified. Fuel economy demands and more sophisticated electronic controls have made automatic transmissions not only more complex, but also unique to each vehicle manufacturer. Long gone are the days of having just a couple choices of automatic transmission fluid type. IDEMITSU is the factory fill Automatic Transmission Fluid (ATF) supplier to most Asian imports. IDEMITSU application-specific ATF products match the exact friction materials and performance requirements of each different vehicle model for which they are made.
Product Features:
See More
Product Features:
- Precisely engineered frictional characteristics guarantee smooth shifting and outstanding anti-shudder performance
- Optimized viscosity and advanced friction reducing additive technology provide exceptional fuel economy performance
- Excellent resistance to oxidation and thermal breakdown provide long fluid life and extended protection
- Exceptional wear protection of gears and bearings
- Provides superior deposit control and protects metal surfaces from rust and corrosion
- Excellent seal compatibility and conditioning reduces risk of fluid leaks due to seal shrinkage, hardening and cracking
Upgrade your 2022 Lexus ES250 with Top-Quality Drivetrains
When it comes to maintaining or upgrading your 2022 Lexus ES250, nothing is more important than using high-quality OEM or aftermarket parts that you can trust. Whether you’re repairing damage to your Lexus or enhancing its overall performance, Drivetrains are key to keeping your ES250 functioning at its best. At Advance Auto Parts, we offer a wide selection of 3 Drivetrains for the 2022 Lexus ES250, designed to meet your needs without breaking the bank.
From
Spindle
replacements to
Differentials
upgrades, we’ve got you covered with parts that fit your vehicle perfectly and ensure long-lasting performance.
Affordable Prices and Wide Selection
Shopping for Drivetrains for any vehicle can be a hassle, especially if you’re on a budget. But with Advance Auto Parts, you can find high-quality Drivetrains for your 2022 Lexus ES250 at great prices.
Our Drivetrains inventory for this model
ranges from just $10.99 to $18.99, with
an average price of $13.82.
Our 3 Drivetrains in stock come from 3 trusted brands, so you’re sure to find the right part for your 2022 Lexus ES250 without overspending.
Explore Related Parts and More
While you’re here, don’t forget to check out other essential categories that go hand in hand with Drivetrain upgrades. Explore related part types like Batteries and Chargers, Oil and Lubricants
and more to make sure your 2022 Lexus ES250 is always ready to roll. We’re committed to providing you with everything you need to keep your ES250 in top shape, all in one place.
Start shopping confidently below for your 2022 Lexus ES250!
Best-Selling Spindles for 2022 Lexus ES250s
Enhance the driving experience in your Lexus with 1 quality Spindle components, starting at $10.99.
Dorman – Spindle Nut M22-1.50 Hex Star Pattern (sold by each) (Part No.615-224)
from
$10.99
This spindle nut is designed to match the fit and function of the original part on specified vehicles. Made of quality materials, it is engineered for reliable performance.
Product Features:
See More
Product Features:
- Direct replacement – this spindle nut matches the fit and function of the factory part on specified years, makes and models
- Ideal solution – this nut is a reliable replacement for an original part that is missing or has failed due to fatigue
- Durable construction – this part is made from quality materials to ensure reliable performance and long service life
- Trustworthy quality – backed by team of product experts in the United States and more than a century of automotive experience
Most Popular 2022 Lexus ES250 Differentials
Customize your Lexus with 1 Differentials products
like Differential Oil, all
priced under $18.99.
Valvoline – Flex Fill Transmission & Differential Gear Oil: Full Synthetic 75W-90, 1 Quart (Part No.889785)
from
$18.99
We’ve squeezed innovation into every ounce of Valvoline FlexFill SAE 75W-90 Full Synthetic Gear Oil, the ultimate gear protection in hypoid rear differentials and non-synchronized manual transmissions. Our unique new flexible pouch makes getting into the tightest places to lubricate gears easier than ever and with less waste. The superior detergent package-based formulation contains fully synthetic basestocks and special additives that help protect parts from rust and corrosion while providing exceptional high and low temperature protection and excellent thermal stability, especially in demanding driving situations such as towing and off-roading. It contains an extreme pressure additive for better load carrying capacity, wear resistance additives that assist in protecting gear teeth, a limited slip additive for optimal clutch pack performance, and an anti-foaming agent for better lubrication and service life. Valvoline FlexFill SAE 75W-90 Full Synthetic Gear Oil is recommended for use in axle applications requiring factory-fill or drain-and-fill levels for limited slip performance.
Product Features:
See More
Product Features:
- FLEXIBLE POUCH FOR EASIER USE WITH LESS WASTE in tight, hard to reach undercarriage situations.
- EXCEPTIONAL HIGH AND LOW TEMPERATURE PROTECTION ranging from -30F to 300F degrees for dependable coverage year-round
- REDUCES CHATTERING AND PROTECTS GEAR TEETH from oxidation, rust, and wear
- MEETS THE DEMANDS OF CONVENTIONAL AND LIMITED SLIP REAR DIFFERENTIALS where API GL-5 is specified, as well as non-synchronized manual transmissions that require API GL-4 or MT-1 fluid
- MEETS OR EXCEEDS PERFORMANCE REQUIREMENTS for Mack GO-H and GO-J; API GL-5 and API MT-1; MIL-PRF-2105E; and SAE J2360
Top Picks for 2022 Lexus ES250 Drive Shafts and Axles
Upgrade Lexus ES250s with top-quality Drive Shafts and Axles parts, including 1 OEM and aftermarket selections for your 2022 model.
National – Drive Axle Shaft Seal (Part No.711096)
from
$11.49
National has built a reputation as one of the most respected names in the industry. We have offered premium sealing solutions for more than 75 years. Our design team keeps pace with the industry and provides advanced solutions for today’s vehicles.
Product Features:
See More
Product Features:
- Design type: spring loaded; multi-lip
- Temperature range: -20 Deg. F to 300 Deg. F / -29 Deg. C to 49 Deg. C
- Resistance to EP lubricants
- Low swell in hydrocarbon fluids
- Delivers quality and reliable performance for every type of repair
FAQs for 2022 Lexus ES250 Drivetrains
Which Drivetrains are best-sellers for 2022 Lexus ES250s?
Out of 3 Drivetrains that fit 2022 Lexus ES250s, the following parts are the top sellers:
- Flex Fill Transmission & Differential Gear Oil: Full Synthetic 75W-90, 1 Quart (12507273) – $18.99
- Spindle Nut M22-1.50 Hex Star Pattern (sold by each) (10998725) – $10.99
- Drive Axle Shaft Seal (12091281) – $11.49
What’s the price range for 2022 Lexus ES250 Drivetrains?
Drivetrain prices for the 2022 Lexus ES250 start at $10.99 and go up to $18.99 for the most premium parts.
What’s the average price of a Drivetrain for a 2022 Lexus ES250?
The average price for Drivetrains for the 2022 Lexus ES250 is $13.82. Keep in mind the variety of part types within our Drivetrain category so you are likely to find a wide range of prices across a variety of parts and components.
Does Advance Auto Parts sell Drivetrains for other Lexus ES250 model years?
What are the cheapest Drivetrains for my 2022 Lexus ES250?
The cheapest 2022 Lexus ES250 Drivetrains we carry in stock are:
- Spindle Nut M22-1.50 Hex Star Pattern (sold by each) (10998725) – $10.99
- Drive Axle Shaft Seal (12091281) – $11.49
- Flex Fill Transmission & Differential Gear Oil: Full Synthetic 75W-90, 1 Quart (12507273) – $18.99
What types of Drivetrains do you sell for my 2022 Lexus ES250?
As of 11/2/25, these are some of the most in-demand types of Drivetrains for a 2022 Lexus ES250:
Can I get help with 2022 Lexus ES250 Drivetrain orders?
Contact our customer support team, by chat or phone, through the help desk page, where you can find instant answers about Lexus Drivetrains and more.
What is your return policy for Lexus ES250 Drivetrains?
Advance Auto Parts keeps returns simple. For new Lexus ES250 Drivetrains and accessories, your online orders can be returned, in their original condition, within 45 days. For requirements, see the returns page.
