2022 GMC Sierra 2500 HD Cooling and Climate Controls

Essential 2022 GMC Sierra 2500 HD Cooling and Climate Controls

ACDelco – GM Original Equipment A/C Compressor, New (Part No.R1000757211ACD)

GM Original Equipment A/C Compressor, New

from

$415.45
ACDelco GM Original Equipment A/C Compressors and Clutches are GM-recommended replacements for your vehicle’s original components. The compressor pumps the refrigerant through the system. The compressor is typically engine driven via the accessory belt, and the clutch on the compressor is used to engage and disengage the compressor. The compressor is lubricated by refrigerant oil. This original equipment compressor and clutch have been manufactured to fit your specific GM vehicle, providing the same performance, durability, and service life you expect from General Motors.

Product Features:
  • 100% visual- and leak-tested to ensure the component’s quality and durability
  • GM-recommended replacement part for your GM vehicle’s original factory component
  • Offering the quality, reliability, and durability of GM OE
  • Manufactured to GM OE specification for fit, form, and function
See More

KAI – A/C Compressor (Part No.ACP010581)

A/C Compressor

from

$349.99
New Standard Replacement A/C Compressor, H6, 4 Groove, V8 Engine

Product Features:
  • H6, 4 Groove, V8 Engine
  • Meets All Federal Motor Safety Standards
  • No Drilling Needed For Installation
  • No Modifications Needed For Installation
  • Direct Fit Replacement For Your Vehicle
  • Same Form Fit And Function As OE
  • Check Out The Large Selection Of Parts Available For Your Vehicle
See More

ACDelco – GM Original Equipment Expansion Tank Cap (Part No.G1040465619ACD)

GM Original Equipment Expansion Tank Cap

from

$17.61
An ACDelco GM Original Equipment Expansion Tank Cap is a spring loaded cap that seals the radiator filler neck or surge tank, and is a GM-recommended replacement for your vehicle’s original component. It maintains pressure on the cooling system while the engine is operating, which raises the boiling point of the engine coolant. It also replenishes the system with coolant from the expansion tank (if equipped) when the engine cools off. This original equipment radiator cap has been manufactured to fit your specific GM vehicle, providing the same performance, durability, and service life you expect from General Motors. Get the GM quality you know and trust with ACDelco GM Original Equipment Thermostats and Caps. Stay with the brand of parts your General Motors vehicle came with and get peace of mind that the fit, form, and function is up to the high standards and specifications of General Motors. ACDelco GM Original Equipment Thermostats and Caps are engineered for virtually every model of GM car, light duty truck, and sport utility vehicle.

Product Features:
  • Seal and maintain pressure on the cooling system for vehicle safety
  • Raise the boiling point of the engine coolant to maintain efficiency
  • Fit most models of GM vehicles for expanded coverage
  • GM-recommended replacement part for your GM vehicle’s original factory component
  • Offering the quality, reliability, and durability of GM OE
  • Manufactured to GM OE specification for fit, form, and function
See More

Carquest Premium – Radiator Cap: 20 PSI (Part No.10271)

Radiator Cap: 20 PSI

from

$19.79
Crafted to meet the exact specifications set by Original Equipment Manufacturers (OEM), these products are engineered for effortless installation and removal. Constructed from premium-grade components, incorporating proper relief and vacuum valves, they ensure optimal performance even in the most demanding automotive cooling systems. Rigorously quality-tested, these components provide exceptional, out-of-the-box performance and superior durability to meet or exceed the highest standards of today’s vehicles.

Product Features:
  • Maintains proper cooling system pressure
  • Easy installation and removal
  • 100% tested to ensure proper pressure and longevity
  • Meets all OEM specifications
See More

Motorad – Standard Thermostat: With Seals, 180, 185 Degrees (Part No.447448)

Standard Thermostat: With Seals, 180, 185 Degrees

from

$40.99
Manufactured with OEM quality materials and safety standards by an OE Supplier. This thermostat will meet and exceed the expectations of the OE thermostat to insure the best product for your cooling system. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant. Offset design, air relief valve, and OEM style seals included where applicable.

Product Features:
  • High grade stainless steel and copper construction
  • Meets or exceeds OEM standards
  • Consistent and precise response to cooling system needs
  • Original equipment design for worry-free direct fit replacement
  • 100% tested and calibrated
See More

Carquest Premium – Standard Thermostat: With Seal, 180 Degrees (Part No.14738)

Standard Thermostat: With Seal, 180 Degrees

from

$42.99
Carquest Premium Thermostats are manufactured with OEM quality materials and safety standards by an OE Supplier. This thermostat will meet and exceed the expectations of the OE thermostat to insure the best product for your cooling system. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant. Offset design, air relief valve, and OEM style seals included where applicable.

Product Features:
  • High grade stainless steel and copper construction
  • Meets or exceeds OEM standards
  • Consistent and precise response to cooling system needs
  • Original equipment design for worry-free direct fit replacement
  • 100% tested and calibrated
See More

ACDelco – 15-10595 GM Original Equipment Engine Coolant Water Outlet (Part No.G4010349243ACD)

15-10595 GM Original Equipment Engine Coolant Water Outlet

from

$17.81
ACDelco GM Original Equipment Engine Coolant Water Outlets are housings that connect the radiator hoses to the engine, typically housing the engine coolant thermostat. For certain applications, the water outlet contains threaded holes or ports for sensors and switches. These original equipment engine coolant water outlets are GM-recommended replacements for your vehicle’s original components and have been manufactured to fit your specific GM vehicle, providing the same performance, durability, and service life you expect from General Motors.

Product Features:
  • GM-recommended replacement part for your GM vehicle’s original factory component
  • Offering the quality, reliability, and durability of GM OE
  • Manufactured to GM OE specification for fit, form, and function
See More

Dorman – Water Pump Outlet Pipe (Part No.626-661)

Water Pump Outlet Pipe

from

$82.99
This engine coolant pipe is designed to match the fit and function of the original pipe on specified vehicles. It is engineered to help ensure leak-free coolant transfer when an original pipe has failed from heat or corrosion..

Product Features:
  • Direct replacement – this engine coolant pipe is designed to match the fit and function of the original pipe on specified vehicles.
  • Ideal solution – engineered to help ensure leak-free coolant transfer when an original pipe has failed from heat or corrosion
  • Durable construction – designed and manufactured to strict specifications for reliable performance
  • Trustworthy quality – backed by a team of product experts in the United States and more than a century of automotive experience
See More

NTK – Engine Coolant Temperature Sensor (Part No.EF0075)

Engine Coolant Temperature Sensor

from

$38.99
The Engine Coolant Temperature Sensor determines the exact temperature of the engine coolant by sending an analog signal to the ECM to censure proper air/fuel ratio along with proper operation of the cooling fan(s) and temperature gauge. The Engine Coolant Temperature Sensor may be located on the cylinder head, engine block, thermostat housing or intake manifold. Reasons for replacement include: check engine light illumination, erratic or no temperature gauge operation, erratic or no cooling fan operation, and engine overheating.

Product Features:
  • OE MATCHED: Wires and probe length match OE. Mounting clip(s) included where applicable
  • FASTER RESPONSE TIME: Thermal conductive grease inside brass housing increases sensor response time
  • THE NTK DIFFERENCE: Thread sealant/o-ring installed where applicable. Thermistor placement within the housing matches OE to ensure proper output. Proper thermal conductive grease to provide accurate temperature transfer to the thermistor
See More

Carquest Premium – Engine Coolant Temperature Sensor (Part No.FTA1002)

Engine Coolant Temperature Sensor

from

$62.99
CARQUEST premium engine management products provide the right products for a wide range of domestic and import applications. Delivering the highest performance and durability under demanding conditions.
See More

Dorman – Coolant Bypass Tube O-Ring Kit (Part No.926-424)

Coolant Bypass Tube O-Ring Kit

from

$19.29
This coolant O-ring kit contains all the necessary O-rings to replace or repair the engine coolant pipe on specified vehicles.

Product Features:
  • Ideal replacement – this coolant O-ring kit matches the factory O-rings to ensure a complete and reliable repair
  • Durable construction – made of quality materials for leak-free service
  • Complete solution – includes all O-rings required to repair or replace specified coolant pipe
  • Quality tested – this part has undergone try-on and material testing to ensure a quality fit and long service life
See More

Felpro – Multi-Purpose O-Ring (Part No.35759)

Multi-Purpose O-Ring

from

$1.79
Fel-Pro gaskets offer 100% vehicle sealing with application-specific materials to give you sealing solutions with the performance and durability professionals trust

Product Features:
  • Meets or exceeds all original equipment specifications
  • Application specific design to ensure a perfect fit
  • Engineered and manufactured specifically for the repair environment
  • Unsurpassed quality you can trust
  • Each Fel-Pro gasket, no matter how small, is engineered to exacting standards with proprietary design, engineering and manufacturing processes
See More

ACDelco – A/C Service Valve (Part No.R1129947779ACD)

A/C Service Valve

from

$13.13
A/C Service Valve

GM Genuine Parts – Air Conditioning System Valve Core (Part No.15-1119)

Air Conditioning System Valve Core

from

$10.99
GM Genuine Parts A/C System Valve Cores are designed, engineered, and tested to rigorous standards, and are backed by General Motors. These A/C system valve cores are components of the A/C service valve through which your vehicle’s refrigerant can be accessed and serviced. The valve core is a spring-loaded poppet valve that is opened when the service technician connects the A/C service machine hose couplers. GM Genuine Parts are the true OE parts installed during the production of or validated by General Motors for GM vehicles. Some GM Genuine Parts may have formerly appeared as ACDelco GM Original Equipment (OE).

Product Features:
  • Repair leaking A/C system, restore A/C function
  • Helps restore A/C Function
  • Some GM Genuine Parts may have formerly appeared as ACDelco GM Original Equipment (OE)
  • GM Engineers design and validate OE parts specifically for your Chevrolet, Buick, GMC, or Cadillac vehicle
  • Original equipment parts are designed to work with your GM vehicle safety systems — aftermarket replacement parts may not meet the same OE safety regulations, depending on the part type
  • GM regularly updates production and service part designs to integrate new materials and technologies
See More

Dorman – Clutch Fan Blade: Plastic, Cost Effective And Reliable (Part No.621-111)

Clutch Fan Blade: Plastic, Cost Effective And Reliable

from

$111.99
Replace your damaged cooling fan blade with this direct replacement. This vehicle-specific application is engineered for a perfect fit and is made from quality materials to ensure durability and restore proper cooling system operation.

Product Features:
  • Direct replacement – this engine cooling fan blade fits and functions like the original equipment fan blade
  • Quality construction – manufactured from premium materials for a long service life
  • Excellent value – original equipment quality at a lower price
  • Quality tested – has undergone testing to ensure proper fit and performance
See More

Dorman – Clutch Fan Blade: Plastic, Cost Effective And Reliable (Part No.621-104)

Clutch Fan Blade: Plastic, Cost Effective And Reliable

from

$61.99
Replace your damaged cooling fan blade with this direct replacement. This vehicle-specific application is engineered for a perfect fit and is made from quality materials to ensure durability and restore proper cooling system operation.

Product Features:
  • Direct replacement – this engine cooling fan blade fits and functions like the original equipment fan blade
  • Quality construction – manufactured from premium materials for a long service life
  • Excellent value – original equipment quality at a lower price
  • Quality tested – has undergone testing to ensure proper fit and performance
See More

GM Genuine Parts – Engine Cooling Fan Clutch (Part No.15-4964)

Engine Cooling Fan Clutch

from

$397.99
GM Genuine Parts Engine Cooling Fan Clutches are designed, engineered, and tested to rigorous standards, and are backed by General Motors. These engine cooling fan clutches control the speed of the radiator fan based on the temperature of the air after it passes through the radiator fins. GM Genuine Parts are the true OE parts installed during the production of or validated by General Motors for GM vehicles. Some GM Genuine Parts may have formerly appeared as ACDelco GM Original Equipment (OE).

Product Features:
  • Helps quiet noisy cooling fans with stuck fan clutches
  • Some GM Genuine Parts may have formerly appeared as ACDelco GM Original Equipment (OE)
  • GM Engineers design and validate OE parts specifically for your Chevrolet, Buick, GMC, or Cadillac vehicle
  • Original equipment parts are designed to work with your GM vehicle safety systems — aftermarket replacement parts may not meet the same OE safety regulations, depending on the part type
  • GM regularly updates production and service part designs to integrate new materials and technologies
See More

Carquest Premium – Universal Fan Clutch (Part No.216090)

Universal Fan Clutch

from

$493.99
Product Features:
  • Designed, tested, and built by application
  • OE performance, fit, and appearance
  • Precision machined
  • Out of box installation
See More

GM Genuine Parts – Water Inlet Seal (Part No.12587397)

Water Inlet Seal

from

$8.99
GM Genuine Parts Engine Coolant Thermostat Seals are designed, engineered, and tested to rigorous standards, and are backed by General Motors. These seals help close and prevent coolant from leaking out of your vehicle’s cooling system components. GM Genuine Parts are the true OE parts installed during the production of or validated by General Motors for GM vehicles. Some GM Genuine Parts may have formerly appeared as ACDelco GM Original Equipment (OE).

Product Features:
  • Helps close and prevent coolant from leaking out of your vehicle’s cooling system components to maintain the proper engine temperature
  • Some GM Genuine Parts may have formerly appeared as ACDelco GM Original Equipment (OE)
  • GM Genuine Parts are designed, engineered and tested to rigorous standards, and are backed by General Motors
  • GM Engineers design and validate OE parts specifically for your Chevrolet, Buick, GMC, or Cadillac vehicle
  • GM regularly updates production and service part designs to integrate new materials and technologies
See More

Carquest Premium – Multi Purpose Relay (Part No.RAA1732)

Multi Purpose Relay

from

$36.49
Carquest premium engine management products provide the right products for a wide range of domestic and import applications. Delivering the highest performance and durability under demanding conditions.
See More

ACDelco – Relay (Part No.P2020765633ACD)

Relay

from

$14.65
Relay

Dorman – Coolant Housing/Water Outlet: With Housing, 25 Degree Neck Angle (Part No.902-2081)

Coolant Housing/Water Outlet: With Housing, 25 Degree Neck Angle

from

$13.99
This replacement engine coolant thermostat housing is engineered to match the fit and durability of the stock thermostat housing on specified vehicles. It is designed to withstand extreme temperature changes to extend service life.

Product Features:
  • Ideal replacement – this engine coolant thermostat housing directly replaces the original housing on specified vehicle years, makes and models
  • Durable construction – this part is specifically designed to withstand extreme temperature changes and resist cracking and leaking
  • Cost-effective and reliable – offers original manufacturer quality at lower cost than getting replacement at dealer
  • Industry-leading design – professionally engineered by the aftermarket leader in replacement thermostat housings
See More

Motorad – Coolant Housing/Water Outlet: (Part No.CH6007)

Coolant Housing/Water Outlet:

from

$78.99
Manufactured with OEM quality materials and safety standards by an OE Supplier. This housing will meet and exceed the expectations of the OE thermostat to insure the best product for your cooling system. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. The construction of this housing is improved over the OE design to fix and update any issues that the OE design may have had.

Product Features:
  • Easy, one step fit and installation
  • No special tools required
  • Meets or exceeds all OEM standards
See More

Carquest Premium – Engine Coolant Thermostat Housing (Part No.85254)

Engine Coolant Thermostat Housing

from

$54.99
High quality OE replacement part with all components needed to complete the job

Product Features:
  • Meets and/or exceeds OEM standard
  • Includes quality gasket or O-ring  to ensure proper seal (where applicable
  • Coated with corrosion and rust inhibitor
  • 100% leak tested
  • Direct-fit replacement for ease of installation
See More

ACDelco – Ambient Temp Sensor (Part No.P4025600368ACD)

Ambient Temp Sensor

from

$12.37
Ambient Temp Sensor

ACDelco – Cabin Air Temp Sen. (Part No.P4119578241ACD)

Cabin Air Temp Sen.

from

$87.86
Cabin Air Temp Sen.

Carquest Premium – Cabin Air Temperature Sensor (Part No.WTA1323)

Cabin Air Temperature Sensor

from

$57.99
CARQUEST premium engine management products provide the right products for a wide range of domestic and import applications. Delivering the highest performance and durability under demanding conditions.
See More

ACDelco – Instrument Panel Air Duct Air Temperature Sensor (Part No.15-5632)

Instrument Panel Air Duct Air Temperature Sensor

from

$9.99
ACDelco GM Original Equipment HVAC Temperature Sensor is a GM-recommended replacement component for one or more of the following vehicle systems: hvac. This original equipment sensor will provide the same performance, durability, and service life you expect from General Motors.

Product Features:
  • GM-recommended replacement part for your GM vehicle’s original factory component
  • Offering the quality, reliability, and durability of GM OE
  • Manufactured to GM OE specification for fit, form, and function
See More

2022 GMC Sierra 2500 HD Cooling and Climate Controls

You count on your 2022 GMC Sierra 2500 HD to run right. That means taking care of it with regular maintenance, necessary repairs, and the right parts. Advance Auto Parts can help with all of that thanks to our extensive inventory of trusted Cooling and Climate Controls. With 23 Cooling and Climate Controls ranging in price from $8.72 to $350.66, you’re sure to find everything you need for your 2022 GMC Sierra 2500 HD.

Brands matter. If you want to shop a specific Cooling and Climate Controls brand, we stock 6 different brands like Carquest Premium, Motorad, and Dorman. 2022 GMC Sierra 2500 HD Cooling and Climate Controls start as low as $8.72!

One of the best ways to find top quality OEM or aftermarket Cooling and Climate Controls is by asking professionals. Short of that, you can shop with confidence thanks to our 231 extensive product reviews on 2022 GMC Sierra 2500 HD Cooling and Climate Controls. Some of the top-rated Cooling and Climate Controls products we carry are Engine Coolant Reservoir Cap: Twist, Plastic, 1 Pack with 5.0 stars.

Did we mention you can order your Cooling and Climate Controls from our online catalog and have them shipped right to your garage? Or, if you feel like seeing the parts first-hand, search for your nearest Advance Auto Parts location above and pick up in-store when you’re ready. Browse our full Cooling and Climate Controls inventory for your 2022 GMC Sierra 2500 HD below to get started!

Top-Rated Cooling and Climate Controls Brands For Your 2022 GMC Sierra 2500 HD

Trusted Cooling and Climate Controls OEM and aftermarket product brands are what Advance Auto Parts specializes in. The brands we work with are sure to keep that 2022 GMC Sierra 2500 HD running right for years to come. In our inventory you’ll find brands like Carquest Premium, Motorad, Dorman, and even more.

Popular ACDelco Cooling and Climate Controls

You’ll find popular ACDelco brand products across Engine Cooling Parts. All are waiting to get your 2022 GMC Sierra 2500 HD back on the road. Some of the top-rated ACDelco products in these categories are:

Top-Rated Carquest Premium Cooling and Climate Controls


If Carquest Premium are what you’re looking for, our inventory holds plenty. We stock Carquest Premium brand Cooling and Climate Controls for your 2022 GMC Sierra 2500 HD, and some of our most reviewed Carquest Premium parts include:
Standard Thermostat: With Seal, 187 Degrees
from $38.99
(45)
Standard Thermostat: With Seal, 187 Degrees
Thermostats
Standard Thermostat: With Seal, 180 Degrees
from $42.99
(7)
Standard Thermostat: With Seal, 180 Degrees
Thermostats
Standard Thermostat: With Seal, 185 Degrees
from $43.99
(7)
Standard Thermostat: With Seal, 185 Degrees
Thermostats

FAQs for 2022 GMC Sierra 2500 HD Cooling and Climate Controls

What are the most purchased Cooling and Climate Controls for the 2022 GMC Sierra 2500 HD?

Out of 23 Cooling and Climate Controls for the 2022 GMC Sierra 2500 HD, the most popular in our inventory are:
Engine Coolant Reservoir Cap: Twist, Plastic, 1 Pack
from $16.99
This product is not rated
Engine Coolant Reservoir Cap: Twist, Plastic, 1 Pack
Coolant Reservoir Caps
Air Conditioning System Valve Core
from $10.99
(6)
Air Conditioning System Valve Core
AC Caps and Valve Core Kits

What are the top-rated 2022 GMC Sierra 2500 HD Cooling and Climate Controls?

Top-rated Cooling and Climate Controls for your 2022 GMC Sierra 2500 HD based on customer reviews/ratings are:
Engine Coolant Reservoir Cap: Twist, Plastic, 1 Pack
from $12.99
(1)
Engine Coolant Reservoir Cap: Twist, Plastic, 1 Pack
“Fits perfect”