2021 Mercedes-Benz S500 Cooling and Climate Controls

Essential Cooling and Climate Controls for 2021 Mercedes-Benz S500s

Rein – Radiator Mount (Part No.AVM0699)

Radiator Mount

from

$19.99
Anti-vibration parts dampen vibration harmonics from the engine and drive line components to rest of the vehicle. This in turn reduces vibration and noise which can be felt and heard while the vehicle is in operation. Rein Automotive anti-vibration parts are application specific and match the design and function of the OE parts.

Product Features:
  • Rubber components match the shore hardness of the original equipment bushing to ensure maximum performance and product longevity.
  • Part has a high corrosion resistance for maximum life.
  • Produced with high quality materials to ensure maximum life and a smooth ride.
  • Made by the OE manufacturer.
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Carquest Premium – COOLANT HOUSING (Part No.CH2084)

COOLANT HOUSING

from

$853.99
COOLANT HOUSING

ACM – A/C Evaporator Temperature Sensor (Part No.R1071178654ACM)

A/C Evaporator Temperature Sensor

from

$55.97
ACM is a supplier of Original Equipment quality climate control products.
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ACM – A/C Schrader Valve C (Part No.R1138570550ACM)

A/C Schrader Valve C

from

$2.92
A/C Schrader Valve C

Carquest Premium – A/C Refrigerant Pressure Sensor (Part No.ACA2004)

A/C Refrigerant Pressure Sensor

from

$41.99
The Carquest Premium line of vehicle electronics are designed for OE form, fit and function for both import and domestic vehicles. The A/C Pressure Sensor reports system pressures to the on-board computer, in turn allowing the computer to properly and efficiently control the compressor, fans and system levels. An improperly functioning A/C Pressure Sensor will provide erratic or inaccurate readings to on-board computers severely affecting system performance and function. Without reliable and accurate data from a properly functioning A/C Pressure Sensor, on-board computers are unable to protect the safety of critical components and the system as a whole which can lead to excessive wear and tear on critical components and costly system damage.

Product Features:
  • Designed and manufactured with high quality materials, industry leading electronic components and strict quality controls. Engineered to exceed OE performance and to meet the uncompromising demands of service professionals.
  • Direct fit replacement matches proper OE fit, form, and function and ensures trouble free installation of your A/C Pressure Sensor.
  • All units are helium leak tested on fully automated mass spectrometer equipment before end-of-line testing.
  • All units are tested using automated end-of-line testing equipment that pressurizes the A/C Pressure Sensor and checks full-spectrum functionality and electrical output to ensure each A/C Pressure Sensor meets manufacturing specifications before packaging
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Delphi – Engine Coolant Temperature Sensor (Part No.TS10263)

Engine Coolant Temperature Sensor

from

$32.99
Delphi temperature sensors are built with the latest OE technology; Delphi temperature sensors use durable, one-piece design; Delphi temperature sensors are impervious to electrical noise and interference.

Product Features:
  • Delphi temperature sensors deliver accurate readings and optimal performance
  • Delphi’s one-piece design and automated production process eliminates internal connectors and failure points
  • Each sensor is electrically insulated to eliminate interference from other components in the vehicle
  • Delphi temperature sensors are impervious to electrical noise and interference
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Carquest Premium – Coolant Temperature Sensor with O-Ring and Install Clip (Part No.WTC1122)

Coolant Temperature Sensor with O-Ring and Install Clip

from

$19.99
Approved materials for increased durability in even the most extreme temperatures. All MotoRad Coolant Temperature Sensors are designed to meet or exceed OEM specifications at our ISO TS16949 manufacturing facilities.

Product Features:
  • 100% factory resistance calibrated to ensure precision tolerances, resulting in extremely accurate temperature for optimal performance
  • Thread Sealant and/or O-ring pre-installed on applicable sensors to ensure leak free performance
  • Brass sensor housing precision machined to meet or exceed OE thermal conductivity
  • OE precision matched thermistor position for correct output parameters
  • Extensive product testing includes salt spray, high/low temperature impact, thermal vibration, durability, static electricity, and micro tension, among other tests, to ensure all sensors meet or exceed OEM specifications.
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Rein – Temperature Sensor (Part No.ELC0074)

Temperature Sensor

from

$14.99
Rein Automotive OE temperature sensors are made to factory specifications ensuring proper fit, form and function. The temperature sensor is used to report exhaust temperatures to the vehicle’s ECU. The vehicle uses this information to control engine and emission paramaters. Rein temperature sensors include a vehicle specific connector that fits directly into the factory plug. Our quality temperature sensors aim to provide the professional repair technician and vehicle owner the peace of mind and trust that is expected from an OE component.

Product Features:
  • Direct OE replacemet
  • Designed to meet or exceed factory specifications
  • Made using high quality materials
  • Uses vehicle specific style connector for quick replacement.
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Carquest Premium – Coolant Temperature Sensor with O-Ring (Part No.WTC1075)

Coolant Temperature Sensor with O-Ring

from

$25.99
Approved materials for increased durability in even the most extreme temperatures. All MotoRad Coolant Temperature Sensors are designed to meet or exceed OEM specifications at our ISO TS16949 manufacturing facilities.

Product Features:
  • 100% factory resistance calibrated to ensure precision tolerances, resulting in extremely accurate temperature for optimal performance
  • Thread Sealant and/or O-ring pre-installed on applicable sensors to ensure leak free performance
  • Brass sensor housing precision machined to meet or exceed OE thermal conductivity
  • OE precision matched thermistor position for correct output parameters
  • Extensive product testing includes salt spray, high/low temperature impact, thermal vibration, durability, static electricity, and micro tension, among other tests, to ensure all sensors meet or exceed OEM specifications.
See More

ACM – Air Conditioning Pressure Switch (Part No.R1054445297ACM)

Air Conditioning Pressure Switch

from

$69.77
ACM is a supplier of Original Equipment quality climate control products. 3 pin connector
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Rein – Cap-Expansion Tank (Part No.CPE0026P)

Cap-Expansion Tank

from

$11.49
Rein Automotive OE Quality expansion tank caps are designed to be direct replacements for OE caps. Rein caps are designed to match or exceed the OE materials used and are produced to the highest standards to ensure long service life. Rein Automotive OE quality expansion tank caps keep the coolant system at the proper pressure just like the OE cap.

Product Features:
  • Manufactured to strict engineering standards/specifications in materials and tolerances.
  • Direct fit.
  • Meets or exceeds pressure specifications demanded by the OE manufacturer.
  • Produced by an original equipment supplier.
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Carquest Premium – Engine Coolant Reservoir Cap (Part No.10253)

Engine Coolant Reservoir Cap

from

$19.79
Manufactured to meet all OEM specifications. Designed to be easy to install and remove. Manufactured from high quality components with proper relief and vacuum valves. Quality tested to stand up to even the most demanding automotive cooling systems.

Product Features:
  • Maintains proper cooling system pressure
  • Easy installation and removal
  • 100% tested to ensure proper pressure and longevity
  • Meets all OEM specifications
See More

Rein – Cap-Expansion Tank (Part No.CPE0029P)

Cap-Expansion Tank

from

$29.99
Rein Automotive OE Quality expansion tank caps are designed to be direct replacements for OE caps. Rein caps are designed to match or exceed the OE materials used and are produced to the highest standards to ensure long service life. Rein Automotive OE quality expansion tank caps keep the coolant system at the proper pressure just like the OE cap.

Product Features:
  • Manufactured to strict engineering standards/specifications in materials and tolerances.
  • Direct fit.
  • Meets or exceeds pressure specifications demanded by the OE manufacturer.
  • Produced by an original equipment supplier.
See More

Upgrade your 2021 Mercedes-Benz S500 with Top-Quality Cooling and Climate Controls

When it comes to maintaining or upgrading your 2021 Mercedes-Benz S500, nothing is more important than using high-quality OEM or aftermarket parts that you can trust. Whether you’re repairing damage to your Mercedes-Benz or enhancing its overall performance, Cooling and Climate Controls are key to keeping your S500 functioning at its best. At Advance Auto Parts, we offer a wide selection of 11 Cooling and Climate Controls for the 2021 Mercedes-Benz S500, designed to meet your needs without breaking the bank. From Engine Cooling Part replacements to Air Conditioning Parts upgrades, we’ve got you covered with parts that fit your vehicle perfectly and ensure long-lasting performance.

Affordable Prices and Wide Selection

Shopping for Cooling and Climate Controls for any vehicle can be a hassle, especially if you’re on a budget. But with Advance Auto Parts, you can find high-quality Cooling and Climate Controls for your 2021 Mercedes-Benz S500 at great prices. Our Cooling and Climate Controls inventory for this model ranges from just $2.92 to $853.99, with an average price of $104.57. Our 11 Cooling and Climate Controls in stock come from 4 trusted brands, so you’re sure to find the right part for your 2021 Mercedes-Benz S500 without overspending.

Top Brands and High Customer Satisfaction

Advance Auto Parts takes pride in offering only the best brands in the automotive industry. For your 2021 Mercedes-Benz S500, we stock popular OEM and aftermarket Cooling and Climate Controls from top names like Carquest Premium, and more. Carquest Premium Cooling and Climate Controls start at just $19.79 and boast an impressive 4 stars average rating from customers. With 1 customer reviews and counting, our 2021 Mercedes-Benz S500 Cooling and Climate Controls have a strong track record of reliability, ensuring you can trust your purchase.

Explore Related Parts and More

While you’re here, don’t forget to check out other essential categories that go hand in hand with Cooling and Climate Control upgrades. Explore related part types like Oil and Lubricants, Fluids and Chemicals and more to make sure your 2021 Mercedes-Benz S500 is always ready to roll. We’re committed to providing you with everything you need to keep your S500 in top shape, all in one place. Start shopping confidently below for your 2021 Mercedes-Benz S500!

Best-Selling Engine Cooling Parts for 2021 Mercedes-Benz S500s

Enhance the driving experience in your Mercedes-Benz with 7 quality Engine Cooling Part components, starting at $15.79.

Carquest Premium – Engine Coolant Reservoir Cap (Part No.10253)

Engine Coolant Reservoir Cap

from

$19.79
Manufactured to meet all OEM specifications. Designed to be easy to install and remove. Manufactured from high quality components with proper relief and vacuum valves. Quality tested to stand up to even the most demanding automotive cooling systems.

Product Features:
  • Maintains proper cooling system pressure
  • Easy installation and removal
  • 100% tested to ensure proper pressure and longevity
  • Meets all OEM specifications
See More

Carquest Premium – Coolant Temperature Sensor with O-Ring and Install Clip (Part No.WTC1122)

Coolant Temperature Sensor with O-Ring and Install Clip

from

$19.99
Approved materials for increased durability in even the most extreme temperatures. All MotoRad Coolant Temperature Sensors are designed to meet or exceed OEM specifications at our ISO TS16949 manufacturing facilities.

Product Features:
  • 100% factory resistance calibrated to ensure precision tolerances, resulting in extremely accurate temperature for optimal performance
  • Thread Sealant and/or O-ring pre-installed on applicable sensors to ensure leak free performance
  • Brass sensor housing precision machined to meet or exceed OE thermal conductivity
  • OE precision matched thermistor position for correct output parameters
  • Extensive product testing includes salt spray, high/low temperature impact, thermal vibration, durability, static electricity, and micro tension, among other tests, to ensure all sensors meet or exceed OEM specifications.
See More

Carquest Premium – COOLANT HOUSING (Part No.CH2084)

COOLANT HOUSING

from

$853.99
COOLANT HOUSING

Rein – Cap-Expansion Tank (Part No.CPE0029P)

Cap-Expansion Tank

from

$29.99
Rein Automotive OE Quality expansion tank caps are designed to be direct replacements for OE caps. Rein caps are designed to match or exceed the OE materials used and are produced to the highest standards to ensure long service life. Rein Automotive OE quality expansion tank caps keep the coolant system at the proper pressure just like the OE cap.

Product Features:
  • Manufactured to strict engineering standards/specifications in materials and tolerances.
  • Direct fit.
  • Meets or exceeds pressure specifications demanded by the OE manufacturer.
  • Produced by an original equipment supplier.
See More

Worldpac – EXPANSION TANK CAP (Part No.G10403566322BEH)

EXPANSION TANK CAP

from

$20.03
EXPANSION TANK CAP

Rein – Radiator Mount (Part No.AVM0699)

Radiator Mount

from

$19.99
Anti-vibration parts dampen vibration harmonics from the engine and drive line components to rest of the vehicle. This in turn reduces vibration and noise which can be felt and heard while the vehicle is in operation. Rein Automotive anti-vibration parts are application specific and match the design and function of the OE parts.

Product Features:
  • Rubber components match the shore hardness of the original equipment bushing to ensure maximum performance and product longevity.
  • Part has a high corrosion resistance for maximum life.
  • Produced with high quality materials to ensure maximum life and a smooth ride.
  • Made by the OE manufacturer.
See More

Worldpac – WATER TEMP. SENSOR (Part No.C6020656996FAE)

WATER TEMP. SENSOR

from

$15.79
WATER TEMP. SENSOR

Most Popular 2021 Mercedes-Benz S500 Air Conditioning Parts

Customize your Mercedes-Benz with 4 Air Conditioning Parts products like AC Compressor Pressure Switches, AC Refrigerant Pressure Sensors, and AC Thermal Evaporator Switches, all priced under $69.77.

ACM – Air Conditioning Pressure Switch (Part No.R1054445297ACM)

Air Conditioning Pressure Switch

from

$69.77
ACM is a supplier of Original Equipment quality climate control products. 3 pin connector
See More

ACM – A/C Evaporator Temperature Sensor (Part No.R1071178654ACM)

A/C Evaporator Temperature Sensor

from

$55.97
ACM is a supplier of Original Equipment quality climate control products.
See More

Carquest Premium – A/C Refrigerant Pressure Sensor (Part No.ACA2004)

A/C Refrigerant Pressure Sensor

from

$41.99
The Carquest Premium line of vehicle electronics are designed for OE form, fit and function for both import and domestic vehicles. The A/C Pressure Sensor reports system pressures to the on-board computer, in turn allowing the computer to properly and efficiently control the compressor, fans and system levels. An improperly functioning A/C Pressure Sensor will provide erratic or inaccurate readings to on-board computers severely affecting system performance and function. Without reliable and accurate data from a properly functioning A/C Pressure Sensor, on-board computers are unable to protect the safety of critical components and the system as a whole which can lead to excessive wear and tear on critical components and costly system damage.

Product Features:
  • Designed and manufactured with high quality materials, industry leading electronic components and strict quality controls. Engineered to exceed OE performance and to meet the uncompromising demands of service professionals.
  • Direct fit replacement matches proper OE fit, form, and function and ensures trouble free installation of your A/C Pressure Sensor.
  • All units are helium leak tested on fully automated mass spectrometer equipment before end-of-line testing.
  • All units are tested using automated end-of-line testing equipment that pressurizes the A/C Pressure Sensor and checks full-spectrum functionality and electrical output to ensure each A/C Pressure Sensor meets manufacturing specifications before packaging
See More

ACM – A/C Schrader Valve C (Part No.R1138570550ACM)

A/C Schrader Valve C

from

$2.92
A/C Schrader Valve C

Top-Rated Cooling and Climate Controls Brands For Your 2021 Mercedes-Benz S500

Shop for the best-rated brands offering Cooling and Climate Controls and other products for your 2021 Mercedes-Benz S500s. Below you’ll find some of our best rated Cooling and Climate Controls from Carquest Premium, and more. Cooling and Climate Controls from these brands that fit a 2021 S500 start at just $19.79 and are rated as high as 4 stars. OEM and aftermarket Cooling and Climate Controls don’t get more top quality, durable, and affordable than from the brands below.

Popular Carquest Premium 2021 Mercedes-Benz S500 Cooling and Climate Controls

When it comes to maintaining or upgrading your 2021 Mercedes-Benz S500, using quality Cooling and Climate Controls is essential to ensure durability and a perfect fit. Carquest Premium ticks all of those boxes. We offer a wide selection of Carquest Premium Cooling and Climate Controls, specifically designed for the 2021 Mercedes-Benz S500. With over 4 Carquest Premium brand Cooling and Climate Controls in stock, you’re sure to find what you need. The prices for these top-notch parts start as low as $19.79, with an average price of just $233.94. Plus, with over 1 customer reviews and an average rating of 4 stars, you can trust that our Carquest Premium Cooling and Climate Controls will get the job done right. Choose Advance Auto Parts for reliability, quality, and expert-approved parts that keep your vehicle running strong.

COOLANT HOUSING
from
$853.99
This product is not rated

COOLANT HOUSING

“”

Coolant Temperature Sensor with O-Ring and Install Clip
from
$19.99
This product is not rated

Coolant Temperature Sensor with O-Ring and Install Clip

“”

A/C Refrigerant Pressure Sensor
from
$41.99
This product is not rated

A/C Refrigerant Pressure Sensor

“”

FAQs for 2021 Mercedes-Benz S500 Cooling and Climate Controls

Which Cooling and Climate Controls are best-sellers for 2021 Mercedes-Benz S500s?

Out of 11 Cooling and Climate Controls that fit 2021 Mercedes-Benz S500s, the following parts are the top sellers:

What’s the price range for 2021 Mercedes-Benz S500 Cooling and Climate Controls?

Cooling and Climate Control prices for the 2021 Mercedes-Benz S500 start at $2.92 and go up to $853.99 for the most premium parts.

What’s the average price of a Cooling and Climate Control for a 2021 Mercedes-Benz S500?

The average price for Cooling and Climate Controls for the 2021 Mercedes-Benz S500 is $104.57. Keep in mind the variety of part types within our Cooling and Climate Control category so you are likely to find a wide range of prices across a variety of parts and components.

Does Advance Auto Parts sell Cooling and Climate Controls for other Mercedes-Benz S500 model years?

Yes, we currently carry Cooling and Climate Controls for 16 model years of Mercedes-Benz S500s between 1994 and 2024. Cooling and Climate Controls are bought most frequently for the following model years: 2023, 2022, 2006, 2005, 2004, 2003, 2002, 2001, and 2000.

What are the cheapest Cooling and Climate Controls for my 2021 Mercedes-Benz S500?

The cheapest 2021 Mercedes-Benz S500 Cooling and Climate Controls we carry in stock are:

What are the top-rated Cooling and Climate Controls that fit the 2021 Mercedes-Benz S500?

Out of 1 reviews by customers, our 2021 Mercedes-Benz S500 Cooling and Climate Controls have an average customer rating of . These are some of the highest-rated Cooling and Climate Control types for the 2021 Mercedes-Benz S500 and their top-rated products:

What types of Cooling and Climate Controls do you sell for my 2021 Mercedes-Benz S500?

As of 2/5/25, these are some of the most in-demand types of Cooling and Climate Controls for a 2021 Mercedes-Benz S500:

Can I get help with 2021 Mercedes-Benz S500 Cooling and Climate Control orders?

Contact our customer support team, by chat or phone, through the help desk page, where you can find instant answers about Mercedes-Benz Cooling and Climate Controls and more.

What is your return policy for Mercedes-Benz S500 Cooling and Climate Controls?

Advance Auto Parts keeps returns simple. For new Mercedes-Benz S500 Cooling and Climate Controls and accessories, your online orders can be returned, in their original condition, within 45 days. For requirements, see the returns page.