2021 Mercedes-Benz E350 Drivetrains

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Essential Drivetrains for 2021 Mercedes-Benz E350s

Rein – Rein Drive Shaft Support Bearing, BEM0039P (Part No.BEM0039P)

Rein Drive Shaft Support Bearing, BEM0039P

from

$16.99
Rein Drive Shaft Support Bearing, BEM0039P.
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Driveworks – Driveworks Wheel Bearing and Hub Assembly, NT513388 (Part No.NT513388)

Driveworks Wheel Bearing and Hub Assembly, NT513388

from

$336.99
Driveworks wheel hub assemblies are made with high precision through state-of-the-art technology and manufactured with strict quality-control criteria. Every wheel hub assembly is specifically designed to fit the designated applications and may be used as a direct replacement for the original part. Each part is engineered using OE data and measurements to ensure fitment, performance, and longevity.
See More

Rein – Rein Driveshaft Boot, BKD0066R (Part No.BKD0066R)

Rein Driveshaft Boot, BKD0066R

from

$6.99
Boot kits protect a joint in the car that would be destroyed by dirt, sand and other particles if left exposed, even under normal conditions so it’s important that they be properly maintained and in good condition. Rein Automotive provides application specific driveshaft boot kits that come guaranteed to fit the first time.
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Valvoline – Valvoline Extended Protection Full Synthetic Automatic Transmission Fluid ATF 1 QT, 904976 (Part No.904976)

Valvoline Extended Protection Full Synthetic Automatic Transmission Fluid ATF 1 QT, 904976

from

$15.99
Modern transmissions are better than ever, with more gears to help improve fuel efficiency and acceleration. Greater performance calls for greater protection. Valvoline Extended Protection Full Synthetic ATF features our exclusive Dual Defense Additive Technology for two layers of protection against metal-on-metal contact and thermal breakdown, all while minimizing wear on clutch components. In fact, Valvoline Extended Protection Full Synthetic ATF is 45% stronger against breakdown compared to major brand DEX/MERC oxidative PDSC performance. Proven to maximize transmission life, our patented formula keeps your modern vehicle shifting smoothly, mile after mile, with the ultimate protection you can only expect from Valvoline, the #1 ATF brand.
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Valvoline – Valvoline Multi-Vehicle (ATF) Full Synthetic Automatic Transmission Fluid 1 GA, 904891 (Part No.904891)

Valvoline Multi-Vehicle (ATF) Full Synthetic Automatic Transmission Fluid 1 GA, 904891

from

$35.99
Choosing an automatic transmission fluid just got easier. Valvoline Full Synthetic MaxLife Multi-Vehicle ATF, the #1 ATF product, is suitable for use in 95% of ATF vehicles in operation with US registered light duty applications. And now, it€™s also recommended for most belt and chain-driven continuously variable transmissions (CVT). Featuring advanced additives to prevent the major causes of transmission breakdown, it€™s designed to help prevent leaks, reduce wear and tear, and maximize performance €“ all for much longer than conventional fluids. It has improved thermal stability for longer fluid life, better viscosity stability for consistent transmission operation, and frictional enhancements for smooth gear engagements. Whether your vehicle has a CVT or traditional automatic, Valvoline MaxLife Multi-Vehicle ATF is suitable for a broad range of transmissions including Ford, GM, Toyota, Honda, Nissan, Hyundai, Subaru, BMW, Mercedes, Volvo, VW and Audi vehicles. It€™s specifically recommended for use in the following applications: GM DEXRON-II, DEXRON-III, DEXRON-VI, and DEX-CVT; Ford MERCON LV; Toyota/Lexus Type T, T-II, T-IV, WS, CVTF FE, and CVTF TC. For the many miles ahead, trust your transmission with Valvoline, the #1 automatic transmission fluid brand.
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Upgrade your 2021 Mercedes-Benz E350 with Top-Quality Drivetrains

When it comes to maintaining or upgrading your 2021 Mercedes-Benz E350, nothing is more important than using high-quality OEM or aftermarket parts that you can trust. Whether you’re repairing damage to your Mercedes-Benz or enhancing its overall performance, Drivetrains are key to keeping your E350 functioning at its best. At Advance Auto Parts, we offer a wide selection of 5 Drivetrains for the 2021 Mercedes-Benz E350, designed to meet your needs without breaking the bank. From Drive Shafts and Axle replacements to Differentials upgrades, we’ve got you covered with parts that fit your vehicle perfectly and ensure long-lasting performance.

Affordable Prices and Wide Selection

Shopping for Drivetrains for any vehicle can be a hassle, especially if you’re on a budget. But with Advance Auto Parts, you can find high-quality Drivetrains for your 2021 Mercedes-Benz E350 at great prices. Our Drivetrains inventory for this model ranges from just $6.99 to $336.99, with an average price of $54.32. Our 5 Drivetrains in stock come from 3 trusted brands, so you’re sure to find the right part for your 2021 Mercedes-Benz E350 without overspending.

Explore Related Parts and More

While you’re here, don’t forget to check out other essential categories that go hand in hand with Drivetrain upgrades. Explore related part types like Oil and Lubricants, Fluids and Chemicals and more to make sure your 2021 Mercedes-Benz E350 is always ready to roll. We’re committed to providing you with everything you need to keep your E350 in top shape, all in one place. Start shopping confidently below for your 2021 Mercedes-Benz E350!

Best-Selling Drive Shafts and Axles for 2021 Mercedes-Benz E350s

Enhance the driving experience in your Mercedes-Benz with 2 quality Drive Shafts and Axle components, starting at $6.99.

Rein – Rein Drive Shaft Support Bearing, BEM0039P (Part No.BEM0039P)

Rein Drive Shaft Support Bearing, BEM0039P

from

$16.99
Rein Drive Shaft Support Bearing, BEM0039P.
See More

Rein – Rein Driveshaft Boot, BKD0066R (Part No.BKD0066R)

Rein Driveshaft Boot, BKD0066R

from

$6.99
Boot kits protect a joint in the car that would be destroyed by dirt, sand and other particles if left exposed, even under normal conditions so it’s important that they be properly maintained and in good condition. Rein Automotive provides application specific driveshaft boot kits that come guaranteed to fit the first time.
See More

Most Popular 2021 Mercedes-Benz E350 Differentials

Customize your Mercedes-Benz with 2 Differentials products like Differential Oil, all priced under $35.99.

Valvoline – Valvoline Multi-Vehicle (ATF) Full Synthetic Automatic Transmission Fluid 1 GA, 904891 (Part No.904891)

Valvoline Multi-Vehicle (ATF) Full Synthetic Automatic Transmission Fluid 1 GA, 904891

from

$35.99
Choosing an automatic transmission fluid just got easier. Valvoline Full Synthetic MaxLife Multi-Vehicle ATF, the #1 ATF product, is suitable for use in 95% of ATF vehicles in operation with US registered light duty applications. And now, it€™s also recommended for most belt and chain-driven continuously variable transmissions (CVT). Featuring advanced additives to prevent the major causes of transmission breakdown, it€™s designed to help prevent leaks, reduce wear and tear, and maximize performance €“ all for much longer than conventional fluids. It has improved thermal stability for longer fluid life, better viscosity stability for consistent transmission operation, and frictional enhancements for smooth gear engagements. Whether your vehicle has a CVT or traditional automatic, Valvoline MaxLife Multi-Vehicle ATF is suitable for a broad range of transmissions including Ford, GM, Toyota, Honda, Nissan, Hyundai, Subaru, BMW, Mercedes, Volvo, VW and Audi vehicles. It€™s specifically recommended for use in the following applications: GM DEXRON-II, DEXRON-III, DEXRON-VI, and DEX-CVT; Ford MERCON LV; Toyota/Lexus Type T, T-II, T-IV, WS, CVTF FE, and CVTF TC. For the many miles ahead, trust your transmission with Valvoline, the #1 automatic transmission fluid brand.
See More

Valvoline – Valvoline Extended Protection Full Synthetic Automatic Transmission Fluid ATF 1 QT, 904976 (Part No.904976)

Valvoline Extended Protection Full Synthetic Automatic Transmission Fluid ATF 1 QT, 904976

from

$15.99
Modern transmissions are better than ever, with more gears to help improve fuel efficiency and acceleration. Greater performance calls for greater protection. Valvoline Extended Protection Full Synthetic ATF features our exclusive Dual Defense Additive Technology for two layers of protection against metal-on-metal contact and thermal breakdown, all while minimizing wear on clutch components. In fact, Valvoline Extended Protection Full Synthetic ATF is 45% stronger against breakdown compared to major brand DEX/MERC oxidative PDSC performance. Proven to maximize transmission life, our patented formula keeps your modern vehicle shifting smoothly, mile after mile, with the ultimate protection you can only expect from Valvoline, the #1 ATF brand.
See More

Top Picks for 2021 Mercedes-Benz E350 Hubs and Hub Assemblies

Upgrade Mercedes-Benz E350s with top-quality Hubs and Hub Assemblies parts, including 1 OEM and aftermarket selections for your 2021 model.

Driveworks – Driveworks Wheel Bearing and Hub Assembly, NT513388 (Part No.NT513388)

Driveworks Wheel Bearing and Hub Assembly, NT513388

from

$336.99
Driveworks wheel hub assemblies are made with high precision through state-of-the-art technology and manufactured with strict quality-control criteria. Every wheel hub assembly is specifically designed to fit the designated applications and may be used as a direct replacement for the original part. Each part is engineered using OE data and measurements to ensure fitment, performance, and longevity.
See More

FAQs for 2021 Mercedes-Benz E350 Drivetrains

Which Drivetrains are best-sellers for 2021 Mercedes-Benz E350s?

Out of 5 Drivetrains that fit 2021 Mercedes-Benz E350s, the following parts are the top sellers:

What’s the price range for 2021 Mercedes-Benz E350 Drivetrains?

Drivetrain prices for the 2021 Mercedes-Benz E350 start at $6.99 and go up to $336.99 for the most premium parts.

What’s the average price of a Drivetrain for a 2021 Mercedes-Benz E350?

The average price for Drivetrains for the 2021 Mercedes-Benz E350 is $54.32. Keep in mind the variety of part types within our Drivetrain category so you are likely to find a wide range of prices across a variety of parts and components.

Does Advance Auto Parts sell Drivetrains for other Mercedes-Benz E350 model years?

Yes, we currently carry Drivetrains for 16 model years of Mercedes-Benz E350s between 2006 and 2026. Drivetrains are bought most frequently for the following model years: 2023, 2022, 2020, 2016, 2015, 2014, 2013, 2012, and 2011.

What are the cheapest Drivetrains for my 2021 Mercedes-Benz E350?

What types of Drivetrains do you sell for my 2021 Mercedes-Benz E350?

Can I get help with 2021 Mercedes-Benz E350 Drivetrain orders?

Contact our customer support team, by chat or phone, through the help desk page, where you can find instant answers about Mercedes-Benz Drivetrains and more.

What is your return policy for Mercedes-Benz E350 Drivetrains?

Advance Auto Parts keeps returns simple. For new Mercedes-Benz E350 Drivetrains and accessories, your online orders can be returned, in their original condition, within 45 days. For requirements, see the returns page.