2021 Lexus RX450h Cooling and Climate Controls

Essential Cooling and Climate Controls for 2021 Lexus RX450hs

AISIN – Inverter Cooler Water Pump (Part No.G7010436120ASC)

Inverter Cooler Water Pump

from

$306.71
Inverter Cooler Water Pump

Carquest Premium – Radiator (Part No.813625)

Radiator

from

$358.99
Carquest Premium radiators are designed and engineered for maximum performance, using the highest-grade materials to ensure all radiators meet or exceed original equipment (O.E.) fit, form and function. Carquest Premium radiators are built by manufacturers that meet IATF 16949 certified framework, an internationally recognized proof of quality in the automotive industry. Most modern vehicles use radiators with plastic tanks and our parts are engineered with integrated ribbing to prevent damage during thermal cycling. Carquest Premium radiators are also 100% tested to ensure a durable, leak-free cooling system repair.

Product Features:
  • Thermal tested under real-life temperature simulations
  • High tensile strength aluminum for maximum crimp strength
  • Plastic tanks are engineeredáwith integrated ribbingáfor addedástrength to withstand cracks, bowing and distortion during thermal cycles
  • Thermal expansion slots extend core life and reduce failure rates by allowing improved core expansion and contraction during systematic heat cycles
See More

Carquest Premium – Radiator Cap: 16 PSI (Part No.10242)

Radiator Cap: 16 PSI

from

$14.99
Crafted to meet the exact specifications set by Original Equipment Manufacturers (OEM), these products are engineered for effortless installation and removal. Constructed from premium-grade components, incorporating proper relief and vacuum valves, they ensure optimal performance even in the most demanding automotive cooling systems. Rigorously quality-tested, these components provide exceptional, out-of-the-box performance and superior durability to meet or exceed the highest standards of today’s vehicles.

Product Features:
  • Maintains proper cooling system pressure
  • Easy installation and removal
  • 100% tested to ensure proper pressure and longevity
  • Meets all OEM specifications
See More

Sankei Switches – Sankei Switches Radiator Cap (Part No.G101045813SAK)

Sankei Switches Radiator Cap

from

$11.27
The Sankei Switches radiator cap range has been developed to operate within original equipment manufacturer’s specifications. A faulty radiator cap can cause your car to boil-over at a lower temperature. Test or replace the coolant cap when servicing the cooling system.

Product Features:
  • Meets Original Equipment specifications.
  • Made from premium materials.
  • Designed to function on open cooling systems and overflow reservoir type systems.
See More

KAI – A/C Evaporator Core (Part No.EVA010733)

A/C Evaporator Core

from

$146.99
New Standard Replacement A/C Evaporator Core

Product Features:
  • Made Of Aluminum
  • Meets All Federal Motor Safety Standards
  • No Drilling Needed For Installation
  • No Modifications Needed For Installation
  • Direct Fit Replacement For Your Vehicle
  • Same Form Fit And Function As OE
  • Check Out The Large Selection Of Parts Available For Your Vehicle
See More

Carquest Premium – A/C Evaporator Parallel Flow (Part No.T54852)

A/C Evaporator Parallel Flow

from

$139.99
Carquest Evaporators are designed to remove heat from the air inside the passenger compartment of a vehicle resulting in cooler air temperatures. They are manufactured to meet or exceed original equipment specifications and are designed to easily fit into the engine compartment.

Product Features:
  • The design and manufacture of the evaporators result in uniform refrigerant distribution with optimal flow for improved performance and maximum heat transfer.
  • The evaporators are constructed to offer a lightweight, compact design that will fit easily within the engine compartment.
  • The surface treatment on each part ensures optimum water drainage to prevent mold and odors in the system.
  • The evaporators are 100% tested to meet or exceed original equipment specifications. Each part is helium tested to ensure no leaks.
  • O-Rings and gaskets necessary for installation are included.
See More

Carquest Premium – Blower Motor: With Wheel (Part No.75830)

Blower Motor: With Wheel

from

$144.99
Carquest Premium Blower Motors are engineered and tested to provide years of trouble free operation. Backed by over 50 years of mobile A/C experience, fix it once and fix it right with Carquest Premium Blower Motors. Meets or exceeds OE design. Magnetic size and properties compare or exceed OEM. Windings meet or exceed OEM Specifications. Motor RPM equivalent to or exceeds OEM motor.

Product Features:
  • Meets or exceeds OE design and performance
  • Magnetic size and properties compare or exceed OEM
  • Windings meet or exceed OEM specifications
  • Motor RPM equivalent to or exceeds OEM motor
See More

Carquest Premium – Blower Motor: With Wheel (Part No.76501)

Blower Motor: With Wheel

from

$161.99
Carquest Premium Blower Motors are engineered and tested to provide years of trouble free operation. Backed by over 50 years of mobile A/C experience, fix it once and fix it right with Carquest Premium Blower Motors. Meets or exceeds OE design. Magnetic size and properties compare or exceed OEM. Windings meet or exceed OEM Specifications. Motor RPM equivalent to or exceeds OEM motor.

Product Features:
  • Meets or exceeds OE design and performance
  • Magnetic size and properties compare or exceed OEM
  • Windings meet or exceed OEM specifications
  • Motor RPM equivalent to or exceeds OEM motor
  • Functionally Equivalent to OE Design
  • Each unit is 100% tested for functional performance and operational noise
  • Hermetically Sealed & Thermally Protected Electronics
See More

Carquest Premium – Multi Purpose Relay (Part No.RAA2117)

Multi Purpose Relay

from

$17.79
Carquest premium engine management products provide the right products for a wide range of domestic and import applications. Delivering the highest performance and durability under demanding conditions.
See More

DENSO – First Time Fit Relay (Part No.P2020194560ND)

First Time Fit Relay

from

$25.84
An electrical relay is sort of a magical device: it takes a small electrical signal and uses it to manage a much more powerful current, permitting electrical systems to be both lighter and more dependable at the same time. DENSO has supplied quality relays to the OE automotive world for over 60 years. The very same performance and dependability are available across the replacement aftermarket with DENSO First Time Fit® relays. Engineered to meet the most stringent automaker standards for shock resistance, arcing, and thermal protection, DENSO auto relays feature the lowest return rates in the industry; that equals value for car owners and repair facilities alike

Product Features:
  • Lead-free, solderless construction prevents heat shock and arcing
  • Controlled contact force, self-adjusting air gap increase longevity of the internal parts
  • Industry-standard packaging and footprint
  • Low heat generation
  • Reduced electrical loads
  • Built to last
See More

Factory Air – Coolant Temp Sensor Switch (Part No.36424)

Coolant Temp Sensor Switch

from

$34.05
High quality OE replacement part with all components needed to complete the job

Product Features:
  • Contains gaskets, O-rings, or seals to properly replace the product
  • Brass construction for accurate temperature sensing
  • Color coded for easy identification
  • Zinc coated terminal to resist corrosion
See More

Carquest Premium – Coolant Temperature Sensor with O-Ring (Part No.WTC2071)

Coolant Temperature Sensor with O-Ring

from

$8.99
Approved materials for increased durability in even the most extreme temperatures. All MotoRad Coolant Temperature Sensors are designed to meet or exceed OEM specifications at our ISO TS16949 manufacturing facilities.

Product Features:
  • 100% factory resistance calibrated to ensure precision tolerances, resulting in extremely accurate temperature for optimal performance
  • Thread Sealant and/or O-ring pre-installed on applicable sensors to ensure leak free performance
  • Brass sensor housing precision machined to meet or exceed OE thermal conductivity
  • OE precision matched thermistor position for correct output parameters
  • Extensive product testing includes salt spray, high/low temperature impact, thermal vibration, durability, static electricity, and micro tension, among other tests, to ensure all sensors meet or exceed OEM specifications.
See More

Felpro – Engine Coolant Thermostat Seal (Part No.35445)

Engine Coolant Thermostat Seal

from

$5.49
Fel-Pro gaskets offer 100% vehicle sealing with application-specific materials to give you sealing solutions with the performance and durability professionals trust

Product Features:
  • Meets or exceeds all original equipment specifications
  • Application specific design to ensure a perfect fit
  • Engineered and manufactured specifically for the repair environment
  • Unsurpassed quality you can trust
  • Validated for fit, form, and function
See More

Felpro – Engine Coolant Outlet Gasket (Part No.35801)

Engine Coolant Outlet Gasket

from

$3.99
Fel-Pro gaskets offer 100% vehicle sealing with application-specific materials to give you sealing solutions with the performance and durability professionals trust

Product Features:
  • Meets or exceeds all original equipment specifications
  • Application specific design to ensure a perfect fit
  • Engineered and manufactured specifically for the repair environment
  • Unsurpassed quality you can trust
  • Validated for fit, form, and function
See More

Carquest Premium – Ambient Air Temperature Sensor (Part No.WTA1121)

Ambient Air Temperature Sensor

from

$43.99
CARQUEST premium engine management products provide the right products for a wide range of domestic and import applications. Delivering the highest performance and durability under demanding conditions.
See More

Metrix – Drier Desiccant Element (Part No.R1043187264MTX)

Drier Desiccant Element

from

$9.99
Drier Desiccant Element

DENSO – First Time Fit Drier Desiccant Element (Part No.R1043393863ND)

First Time Fit Drier Desiccant Element

from

$46.28
The Denso Drier Desiccant Element is a high quality Original Equipment replacement that is manufactured to meet or exceed OE specifications for fit, form, and function.

Product Features:
  • Premium Original Equipment replacement
  • Provides performance and dependability
  • Manufactured to meet OE specifications
See More

Carquest Premium – Engine Coolant Reservoir Cap (Part No.10254)

Engine Coolant Reservoir Cap

from

$9.49
Manufactured to meet all OEM specifications. Designed to be easy to install and remove. Manufactured from high quality components with proper relief and vacuum valves. Quality tested to stand up to even the most demanding automotive cooling systems.

Product Features:
  • Maintains proper cooling system pressure
  • Easy installation and removal
  • 100% tested to ensure proper pressure and longevity
  • Meets all OEM specifications
See More

Carquest Premium – Radiator Cap Tester Adapter (Part No.12024)

Radiator Cap Tester Adapter

from

$16.49
Tester adapter for the MT-300 cooling system pressure testers. Professional grade test equipment to ensure an automotive cooling system is operating at the correct pressure. Made from high quality materials to ensure durability. Designed to test automotive coolant caps.

Product Features:
  • Machined metal construction
  • Works with MT-300 pressure tester
  • Tests coolant caps
  • Professional quality
See More

Carquest Premium – A/C Refrigerant Pressure Sensor (Part No.ACA1745)

A/C Refrigerant Pressure Sensor

from

$83.99
The Carquest Premium line of vehicle electronics are designed for OE form, fit and function for both import and domestic vehicles. The A/C Pressure Sensor reports system pressures to the on-board computer, in turn allowing the computer to properly and efficiently control the compressor, fans and system levels. An improperly functioning A/C Pressure Sensor will provide erratic or inaccurate readings to on-board computers severely affecting system performance and function. Without reliable and accurate data from a properly functioning A/C Pressure Sensor, on-board computers are unable to protect the safety of critical components and the system as a whole which can lead to excessive wear and tear on critical components and costly system damage.

Product Features:
  • Designed and manufactured with high quality materials, industry leading electronic components and strict quality controls. Engineered to exceed OE performance and to meet the uncompromising demands of service professionals.
  • Direct fit replacement matches proper OE fit, form, and function and ensures trouble free installation of your A/C Pressure Sensor.
  • All units are helium leak tested on fully automated mass spectrometer equipment before end-of-line testing.
  • All units are tested using automated end-of-line testing equipment that pressurizes the A/C Pressure Sensor and checks full-spectrum functionality and electrical output to ensure each A/C Pressure Sensor meets manufacturing specifications before packaging
See More

Santech – A/C Pressure Switch (Part No.R1054261110SII)

A/C Pressure Switch

from

$44.70
A/C Pressure Switch

Felpro – Engine Coolant Thermostat Housing Gasket (Part No.35809)

Engine Coolant Thermostat Housing Gasket

from

$5.49
Fel-Pro gaskets offer 100% vehicle sealing with application-specific materials to give you sealing solutions with the performance and durability professionals trust

Product Features:
  • Meets or exceeds all original equipment specifications
  • Application specific design
  • Validated for fit, form, and function
  • Quality that you can trust
  • Each Fel-Pro gasket, no matter how small, is engineered to exacting standards with proprietary design, engineering and manufacturing processes
See More

Stant – THERMOSTAT SEAL (Part No.27286)

THERMOSTAT SEAL

from

$1.49
THERMOSTAT SEAL

Koyo Cooling – Koyo Cooling Radiator (Part No.G1000935601KCS)

Koyo Cooling Radiator

from

$251.78
Plastic Tank / Aluminum Core Radiator Koyo radiators are available in plastic tank and aluminum core. The Nocolok brazing line keeps the highest quality standards, bringing you superior products you can rely on. The Koyo Cooling radiator has been engineered to the highest standards and incorporates application specific mounting locations for all fan shrouds, inlet-outlet hoses and top-bottom mounting pins, ensuring quick and pain-free installs.

Product Features:
  • All Aluminum Core and Plastic Tank
  • OE Style mounting brackets and hose connections
  • Integrated transmission oil cooler when applicable
  • Compact and lightweight
See More

Koyo Cooling – Radiator (Part No.G1000657093KCS)

Radiator

from

$314.12
Radiator

Carquest Premium – Radiator (Part No.813355)

Radiator

from

$189.99
Carquest Premium radiators are designed and engineered for maximum performance, using the highest-grade materials to ensure all radiators meet or exceed original equipment (O.E.) fit, form and function. Carquest Premium radiators are built by manufacturers that meet IATF 16949 certified framework, an internationally recognized proof of quality in the automotive industry. Most modern vehicles use radiators with plastic tanks and our parts are engineered with integrated ribbing to prevent damage during thermal cycling. Carquest Premium radiators are also 100% tested to ensure a durable, leak-free cooling system repair.

Product Features:
  • Thermal tested under real-life temperature simulations
  • High tensile strength aluminum for maximum crimp strength
  • Plastic tanks are engineeredáwith integrated ribbingáfor addedástrength to withstand cracks, bowing and distortion during thermal cycles
  • Thermal expansion slots extend core life and reduce failure rates by allowing improved core expansion and contraction during systematic heat cycles
See More

Carquest Premium – Radiator: With Transmission Oil Cooler (Part No.813207)

Radiator: With Transmission Oil Cooler

from

$294.99
Carquest Premium radiators are designed and engineered for maximum performance, using the highest-grade materials to ensure all radiators meet or exceed original equipment (O.E.) fit, form and function. Carquest Premium radiators are built by manufacturers that meet IATF 16949 certified framework, an internationally recognized proof of quality in the automotive industry. Most modern vehicles use radiators with plastic tanks and our parts are engineered with integrated ribbing to prevent damage during thermal cycling. Carquest Premium radiators are also 100% tested to ensure a durable, leak-free cooling system repair.

Product Features:
  • Thermal tested under real-life temperature simulations
  • High tensile strength aluminum for maximum crimp strength
  • Plastic tanks are engineeredáwith integrated ribbingáfor addedástrength to withstand cracks, bowing and distortion during thermal cycles
  • Thermal expansion slots extend core life and reduce failure rates by allowing improved core expansion and contraction during systematic heat cycles
See More

Carquest Premium – Radiator: With Transmission Oil Cooler (Part No.813596)

Radiator: With Transmission Oil Cooler

from

$259.99
Carquest Premium radiators are designed and engineered for maximum performance, using the highest-grade materials to ensure all radiators meet or exceed original equipment (O.E.) fit, form and function. Carquest Premium radiators are built by manufacturers that meet IATF 16949 certified framework, an internationally recognized proof of quality in the automotive industry. Most modern vehicles use radiators with plastic tanks and our parts are engineered with integrated ribbing to prevent damage during thermal cycling. Carquest Premium radiators are also 100% tested to ensure a durable, leak-free cooling system repair.

Product Features:
  • Thermal tested under real-life temperature simulations
  • High tensile strength aluminum for maximum crimp strength
  • Plastic tanks are engineeredáwith integrated ribbingáfor addedástrength to withstand cracks, bowing and distortion during thermal cycles
  • Thermal expansion slots extend core life and reduce failure rates by allowing improved core expansion and contraction during systematic heat cycles
See More

Upgrade your 2021 Lexus RX450h with Top-Quality Cooling and Climate Controls

When it comes to maintaining or upgrading your 2021 Lexus RX450h, nothing is more important than using high-quality OEM or aftermarket parts that you can trust. Whether you’re repairing damage to your Lexus or enhancing its overall performance, Cooling and Climate Controls are key to keeping your RX450h functioning at its best. At Advance Auto Parts, we offer a wide selection of 23 Cooling and Climate Controls for the 2021 Lexus RX450h, designed to meet your needs without breaking the bank. From HVAC Electrical Part replacements to Blower Motor and Related Products upgrades, we’ve got you covered with parts that fit your vehicle perfectly and ensure long-lasting performance.

Affordable Prices and Wide Selection

Shopping for Cooling and Climate Controls for any vehicle can be a hassle, especially if you’re on a budget. But with Advance Auto Parts, you can find high-quality Cooling and Climate Controls for your 2021 Lexus RX450h at great prices. Our Cooling and Climate Controls inventory for this model ranges from just $5.49 to $358.99, with an average price of $86.22. Our 23 Cooling and Climate Controls in stock come from 10 trusted brands, so you’re sure to find the right part for your 2021 Lexus RX450h without overspending.

Top Brands and High Customer Satisfaction

Advance Auto Parts takes pride in offering only the best brands in the automotive industry. For your 2021 Lexus RX450h, we stock popular OEM and aftermarket Cooling and Climate Controls from top names like FELPRO Carquest Premium, and more. FELPRO Cooling and Climate Controls start at just $5.49 and boast an impressive 5 stars average rating from customers. With 444 customer reviews and counting, our 2021 Lexus RX450h Cooling and Climate Controls have a strong track record of reliability, ensuring you can trust your purchase.

Explore Related Parts and More

While you’re here, don’t forget to check out other essential categories that go hand in hand with Cooling and Climate Control upgrades. Explore related part types like Batteries and Chargers, Oil and Lubricants and more to make sure your 2021 Lexus RX450h is always ready to roll. We’re committed to providing you with everything you need to keep your RX450h in top shape, all in one place. Start shopping confidently below for your 2021 Lexus RX450h!

Best-Selling HVAC Electrical Parts for 2021 Lexus RX450hs

Enhance the driving experience in your Lexus with 1 quality HVAC Electrical Part components, starting at $32.81.

DENSO – Cabin Air Temperatur (Part No.P4028815518ND)

Cabin Air Temperatur

from

$32.81
Cabin Air Temperatur

Most Popular 2021 Lexus RX450h Blower Motor and Related Products

Customize your Lexus with 2 Blower Motor and Related Products products like Blower Motors, all priced under $304.99.

Carquest Premium – Blower Motor: With Wheel (Part No.76513)

Blower Motor: With Wheel

from

$304.99
Carquest Premium Blower Motors are engineered and tested to provide years of trouble free operation. Backed by over 50 years of mobile A/C experience, fix it once and fix it right with Carquest Premium Blower Motors. Meets or exceeds OE design. Magnetic size and properties compare or exceed OEM. Windings meet or exceed OEM Specifications. Motor RPM equivalent to or exceeds OEM motor.

Product Features:
  • Meets or exceeds OE design and performance
  • Magnetic size and properties compare or exceed OEM
  • Windings meet or exceed OEM specifications
  • Motor RPM equivalent to or exceeds OEM motor
  • Functionally Equivalent to OE Design
  • Magnetic size and properties compare or exceed OEM
  • Hermetically Sealed & Thermally Protected Electronics
See More

Carquest Premium – Blower Motor: With Wheel (Part No.75076)

Blower Motor: With Wheel

from

$123.99
Carquest Premium Blower Motors are engineered and tested to provide years of trouble free operation. Backed by over 50 years of mobile A/C experience, fix it once and fix it right with Carquest Premium Blower Motors. Meets or exceeds OE design. Magnetic size and properties compare or exceed OEM. Windings meet or exceed OEM Specifications. Motor RPM equivalent to or exceeds OEM motor.

Product Features:
  • Meets or exceeds OE design and performance
  • Magnetic size and properties compare or exceed OEM
  • Windings meet or exceed OEM specifications
  • Motor RPM equivalent to or exceeds OEM motor
See More

Top Picks for 2021 Lexus RX450h Engine Cooling Parts

Upgrade Lexus RX450hs with top-quality Engine Cooling Parts parts, including 14 OEM and aftermarket selections for your 2021 model.

Felpro – Engine Coolant Thermostat Seal (Part No.35445)

Engine Coolant Thermostat Seal

from

$5.49
Fel-Pro gaskets offer 100% vehicle sealing with application-specific materials to give you sealing solutions with the performance and durability professionals trust

Product Features:
  • Meets or exceeds all original equipment specifications
  • Application specific design to ensure a perfect fit
  • Engineered and manufactured specifically for the repair environment
  • Unsurpassed quality you can trust
  • Validated for fit, form, and function
See More

Sankei Switches – Sankei Switches Radiator Cap (Part No.G101045813SAK)

Sankei Switches Radiator Cap

from

$11.27
The Sankei Switches radiator cap range has been developed to operate within original equipment manufacturer’s specifications. A faulty radiator cap can cause your car to boil-over at a lower temperature. Test or replace the coolant cap when servicing the cooling system.

Product Features:
  • Meets Original Equipment specifications.
  • Made from premium materials.
  • Designed to function on open cooling systems and overflow reservoir type systems.
See More

Felpro – Engine Coolant Thermostat Housing Gasket (Part No.35809)

Engine Coolant Thermostat Housing Gasket

from

$5.49
Fel-Pro gaskets offer 100% vehicle sealing with application-specific materials to give you sealing solutions with the performance and durability professionals trust

Product Features:
  • Meets or exceeds all original equipment specifications
  • Application specific design
  • Validated for fit, form, and function
  • Quality that you can trust
  • Each Fel-Pro gasket, no matter how small, is engineered to exacting standards with proprietary design, engineering and manufacturing processes
See More

Carquest Premium – Radiator Cap: 16 PSI (Part No.10242)

Radiator Cap: 16 PSI

from

$14.99
Crafted to meet the exact specifications set by Original Equipment Manufacturers (OEM), these products are engineered for effortless installation and removal. Constructed from premium-grade components, incorporating proper relief and vacuum valves, they ensure optimal performance even in the most demanding automotive cooling systems. Rigorously quality-tested, these components provide exceptional, out-of-the-box performance and superior durability to meet or exceed the highest standards of today’s vehicles.

Product Features:
  • Maintains proper cooling system pressure
  • Easy installation and removal
  • 100% tested to ensure proper pressure and longevity
  • Meets all OEM specifications
See More

Carquest Premium – Engine Coolant Reservoir Cap (Part No.10254)

Engine Coolant Reservoir Cap

from

$9.49
Manufactured to meet all OEM specifications. Designed to be easy to install and remove. Manufactured from high quality components with proper relief and vacuum valves. Quality tested to stand up to even the most demanding automotive cooling systems.

Product Features:
  • Maintains proper cooling system pressure
  • Easy installation and removal
  • 100% tested to ensure proper pressure and longevity
  • Meets all OEM specifications
See More

Carquest Premium – Radiator Cap Tester Adapter (Part No.12024)

Radiator Cap Tester Adapter

from

$16.49
Tester adapter for the MT-300 cooling system pressure testers. Professional grade test equipment to ensure an automotive cooling system is operating at the correct pressure. Made from high quality materials to ensure durability. Designed to test automotive coolant caps.

Product Features:
  • Machined metal construction
  • Works with MT-300 pressure tester
  • Tests coolant caps
  • Professional quality
See More

DENSO – First Time Fit Relay (Part No.P2020194560ND)

First Time Fit Relay

from

$25.84
An electrical relay is sort of a magical device: it takes a small electrical signal and uses it to manage a much more powerful current, permitting electrical systems to be both lighter and more dependable at the same time. DENSO has supplied quality relays to the OE automotive world for over 60 years. The very same performance and dependability are available across the replacement aftermarket with DENSO First Time Fit® relays. Engineered to meet the most stringent automaker standards for shock resistance, arcing, and thermal protection, DENSO auto relays feature the lowest return rates in the industry; that equals value for car owners and repair facilities alike

Product Features:
  • Lead-free, solderless construction prevents heat shock and arcing
  • Controlled contact force, self-adjusting air gap increase longevity of the internal parts
  • Industry-standard packaging and footprint
  • Low heat generation
  • Reduced electrical loads
  • Built to last
See More

Original Equipment – Expansion Tank Cap (Part No.G10402381532OEA)

Expansion Tank Cap

from

$18.49
Expansion Tank Cap

Carquest Premium – Radiator (Part No.813625)

Radiator

from

$358.99
Carquest Premium radiators are designed and engineered for maximum performance, using the highest-grade materials to ensure all radiators meet or exceed original equipment (O.E.) fit, form and function. Carquest Premium radiators are built by manufacturers that meet IATF 16949 certified framework, an internationally recognized proof of quality in the automotive industry. Most modern vehicles use radiators with plastic tanks and our parts are engineered with integrated ribbing to prevent damage during thermal cycling. Carquest Premium radiators are also 100% tested to ensure a durable, leak-free cooling system repair.

Product Features:
  • Thermal tested under real-life temperature simulations
  • High tensile strength aluminum for maximum crimp strength
  • Plastic tanks are engineeredáwith integrated ribbingáfor addedástrength to withstand cracks, bowing and distortion during thermal cycles
  • Thermal expansion slots extend core life and reduce failure rates by allowing improved core expansion and contraction during systematic heat cycles
See More

Koyo Cooling – Radiator (Part No.G1000657093KCS)

Radiator

from

$314.12
Radiator

Carquest Premium – Radiator: With Transmission Oil Cooler (Part No.813596)

Radiator: With Transmission Oil Cooler

from

$259.99
Carquest Premium radiators are designed and engineered for maximum performance, using the highest-grade materials to ensure all radiators meet or exceed original equipment (O.E.) fit, form and function. Carquest Premium radiators are built by manufacturers that meet IATF 16949 certified framework, an internationally recognized proof of quality in the automotive industry. Most modern vehicles use radiators with plastic tanks and our parts are engineered with integrated ribbing to prevent damage during thermal cycling. Carquest Premium radiators are also 100% tested to ensure a durable, leak-free cooling system repair.

Product Features:
  • Thermal tested under real-life temperature simulations
  • High tensile strength aluminum for maximum crimp strength
  • Plastic tanks are engineeredáwith integrated ribbingáfor addedástrength to withstand cracks, bowing and distortion during thermal cycles
  • Thermal expansion slots extend core life and reduce failure rates by allowing improved core expansion and contraction during systematic heat cycles
See More

Aisan – Water Pump (Part No.G3000838456ASC)

Water Pump

from

$134.77
Water Pump

Carquest Premium – Coolant Temperature Sensor with O-Ring (Part No.WTC2071)

Coolant Temperature Sensor with O-Ring

from

$8.99
Approved materials for increased durability in even the most extreme temperatures. All MotoRad Coolant Temperature Sensors are designed to meet or exceed OEM specifications at our ISO TS16949 manufacturing facilities.

Product Features:
  • 100% factory resistance calibrated to ensure precision tolerances, resulting in extremely accurate temperature for optimal performance
  • Thread Sealant and/or O-ring pre-installed on applicable sensors to ensure leak free performance
  • Brass sensor housing precision machined to meet or exceed OE thermal conductivity
  • OE precision matched thermistor position for correct output parameters
  • Extensive product testing includes salt spray, high/low temperature impact, thermal vibration, durability, static electricity, and micro tension, among other tests, to ensure all sensors meet or exceed OEM specifications.
See More

Autopart International Inc – Radiator Cap (Part No.G10101936436API)

Radiator Cap

from

$7.98
Radiator Cap

In-Demand Air Conditioning Parts for 2021 Lexus RX450hs

Select from 6 premium Air Conditioning Parts parts for your 2021 Lexus RX450h, with prices ranging from $9.99 to $124.99.

DENSO – First Time Fit Drier Desiccant Element (Part No.R1043393863ND)

First Time Fit Drier Desiccant Element

from

$46.28
The Denso Drier Desiccant Element is a high quality Original Equipment replacement that is manufactured to meet or exceed OE specifications for fit, form, and function.

Product Features:
  • Premium Original Equipment replacement
  • Provides performance and dependability
  • Manufactured to meet OE specifications
See More

Carquest Premium – A/C Refrigerant Pressure Sensor (Part No.ACA1745)

A/C Refrigerant Pressure Sensor

from

$83.99
The Carquest Premium line of vehicle electronics are designed for OE form, fit and function for both import and domestic vehicles. The A/C Pressure Sensor reports system pressures to the on-board computer, in turn allowing the computer to properly and efficiently control the compressor, fans and system levels. An improperly functioning A/C Pressure Sensor will provide erratic or inaccurate readings to on-board computers severely affecting system performance and function. Without reliable and accurate data from a properly functioning A/C Pressure Sensor, on-board computers are unable to protect the safety of critical components and the system as a whole which can lead to excessive wear and tear on critical components and costly system damage.

Product Features:
  • Designed and manufactured with high quality materials, industry leading electronic components and strict quality controls. Engineered to exceed OE performance and to meet the uncompromising demands of service professionals.
  • Direct fit replacement matches proper OE fit, form, and function and ensures trouble free installation of your A/C Pressure Sensor.
  • All units are helium leak tested on fully automated mass spectrometer equipment before end-of-line testing.
  • All units are tested using automated end-of-line testing equipment that pressurizes the A/C Pressure Sensor and checks full-spectrum functionality and electrical output to ensure each A/C Pressure Sensor meets manufacturing specifications before packaging
See More

Carquest Premium – A/C Evaporator Parallel Flow (Part No.T64025)

A/C Evaporator Parallel Flow

from

$124.99
Carquest Evaporators are designed to remove heat from the air inside the passenger compartment of a vehicle resulting in cooler air temperatures. They are manufactured to meet or exceed original equipment specifications and are designed to easily fit into the engine compartment.

Product Features:
  • The design and manufacture of the evaporators result in uniform refrigerant distribution with optimal flow for improved performance and maximum heat transfer.
  • The evaporators are constructed to offer a lightweight, compact design that will fit easily within the engine compartment.
  • The surface treatment on each part ensures optimum water drainage to prevent mold and odors in the system.
  • The evaporators are 100% tested to meet or exceed original equipment specifications. Each part is helium tested to ensure no leaks.
  • O-Rings and gaskets necessary for installation are included.
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Santech – A/C Pressure Switch (Part No.R1054261110SII)

A/C Pressure Switch

from

$44.70
A/C Pressure Switch

Carquest Premium – A/C Desiccant Bag Kit (Part No.T83261)

A/C Desiccant Bag Kit

from

$18.99
Carquest Accumulators and Receiver Driers are designed to store, filter and dry the air conditioning refrigerant to provide proper performance and durability for the air conditioning system. They are manufactured to meet or exceed original equipment specifications.

Product Features:
  • All parts meet or exceed original equipment standards for moisture absorption, pressure and temperature resistance, air tightness, vibration resistance, corrosiveness, and pulse pressure.
  • Desiccant is 100% tested and assembled in a controlled environment to ensure performance meets or exceeds original equipment standards.
  • All accumulators and receiver driers are helium leak tested prior to packaging.
  • O-Rings necessary for installation are included.
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Metrix – Drier Desiccant Element (Part No.R1043187264MTX)

Drier Desiccant Element

from

$9.99
Drier Desiccant Element

Top-Rated Cooling and Climate Controls Brands For Your 2021 Lexus RX450h

Shop for the best-rated brands offering Cooling and Climate Controls and other products for your 2021 Lexus RX450hs. Below you’ll find some of our best rated Cooling and Climate Controls from FELPRO and Carquest Premium, and more. Cooling and Climate Controls from these brands that fit a 2021 RX450h start at just $5.49 and are rated as high as 5 stars. OEM and aftermarket Cooling and Climate Controls don’t get more top quality, durable, and affordable than from the brands below.

Popular FELPRO 2021 Lexus RX450h Cooling and Climate Controls

When it comes to maintaining or upgrading your 2021 Lexus RX450h, using quality Cooling and Climate Controls is essential to ensure durability and a perfect fit. FELPRO ticks all of those boxes. We offer a wide selection of FELPRO Cooling and Climate Controls, specifically designed for the 2021 Lexus RX450h. With over 2 FELPRO brand Cooling and Climate Controls in stock, you’re sure to find what you need. The prices for these top-notch parts start as low as $5.49. Plus, with over 79 customer reviews and an average rating of 5 stars, you can trust that our FELPRO Cooling and Climate Controls will get the job done right. Choose Advance Auto Parts for reliability, quality, and expert-approved parts that keep your vehicle running strong.

Engine Coolant Thermostat Seal
from
$5.49

(76)

Engine Coolant Thermostat Seal

“quality product.”

Engine Coolant Thermostat Housing Gasket
from
$5.49

(3)

Engine Coolant Thermostat Housing Gasket

“Just what I needed”

Popular Carquest Premium 2021 Lexus RX450h Cooling and Climate Controls

Carquest Premium auto parts is one of the highest quality Cooling and Climate Control brands in the market. Any 2021 Lexus RX450h owner should feel confident when installing genuine Carquest Premium parts in their vehicle. To ensure the best fit and performance for your 2021 RX450h, Advance Auto Parts carries a full inventory of 11 Carquest Premium Cooling and Climate Controls. Plus you will be keeping your Lexus in peak condition while saving money because prices on these Carquest Premium Cooling and Climate Controls range from $8.99 to $358.99, plus, with more than 142 customer reviews and an impressive 4 stars average rating, you can be confident the Fram Cooling and Climate Controls below will deliver on both quality and value.

Blower Motor: With Wheel
from
$304.99
This product is not rated

Blower Motor: With Wheel

“”

Radiator
from
$358.99
This product is not rated

Radiator

“”

A/C Refrigerant Pressure Sensor
from
$83.99
This product is not rated

A/C Refrigerant Pressure Sensor

“”

FAQs for 2021 Lexus RX450h Cooling and Climate Controls

Which Cooling and Climate Controls are best-sellers for 2021 Lexus RX450hs?

Out of 23 Cooling and Climate Controls that fit 2021 Lexus RX450hs, the following parts are the top sellers:

What’s the price range for 2021 Lexus RX450h Cooling and Climate Controls?

Cooling and Climate Control prices for the 2021 Lexus RX450h start at $5.49 and go up to $358.99 for the most premium parts.

What’s the average price of a Cooling and Climate Control for a 2021 Lexus RX450h?

The average price for Cooling and Climate Controls for the 2021 Lexus RX450h is $86.22. Keep in mind the variety of part types within our Cooling and Climate Control category so you are likely to find a wide range of prices across a variety of parts and components.

Does Advance Auto Parts sell Cooling and Climate Controls for other Lexus RX450h model years?

Yes, we currently carry Cooling and Climate Controls for 12 model years of Lexus RX450hs between 2010 and 2022. Cooling and Climate Controls are bought most frequently for the following model years: 2022, 2020, 2019, 2018, 2017, 2016, 2015, 2014, and 2013.

What are the cheapest Cooling and Climate Controls for my 2021 Lexus RX450h?

The cheapest 2021 Lexus RX450h Cooling and Climate Controls we carry in stock are:

What are the top-rated Cooling and Climate Controls that fit the 2021 Lexus RX450h?

Out of 444 reviews by customers, our 2021 Lexus RX450h Cooling and Climate Controls have an average customer rating of . These are some of the highest-rated Cooling and Climate Control types for the 2021 Lexus RX450h and their top-rated products:

What types of Cooling and Climate Controls do you sell for my 2021 Lexus RX450h?

As of 2/5/25, these are some of the most in-demand types of Cooling and Climate Controls for a 2021 Lexus RX450h:

Can I get help with 2021 Lexus RX450h Cooling and Climate Control orders?

Contact our customer support team, by chat or phone, through the help desk page, where you can find instant answers about Lexus Cooling and Climate Controls and more.

What is your return policy for Lexus RX450h Cooling and Climate Controls?

Advance Auto Parts keeps returns simple. For new Lexus RX450h Cooling and Climate Controls and accessories, your online orders can be returned, in their original condition, within 45 days. For requirements, see the returns page.