2021 Lexus IS350 Engine Coolant and Antifreeze

Your 2021 Lexus IS350 might be the best vehicle you’ve ever owned. Or you may just be struggling to keep it highway-approved. No matter the situation, Advance Auto Parts has the Engine Coolant and Antifreeze you desperately need.

We currently carry 14 Engine Coolant and Antifreeze to choose from for your 2021 Lexus IS350, and our inventory prices range from as little as $10.99 up to $24.99.

On top of low prices, Advance Auto Parts offers 5 different trusted brands of Engine Coolant and Antifreeze for the 2021 Lexus IS350. We only sell parts from trusted brands like Prestone so that you can find quality parts you can count on.

Don’t take our word for it – check out customer ratings and reviews to buy with confidence. We have 287 reviews on our Engine Coolant and Antifreeze for the 2021 Lexus IS350 from previous customers.

Have parts delivered straight to your home, or find the nearest Advance Auto Parts store to check out our Engine Coolant and Antifreeze stock in-person!

Engine Coolant and Antifreeze for Your 2021 Lexus IS350

ZEREX – Asian Vehicle Red 50/50 Ready-to-Use Antifreeze / Coolant, 1 Gallon (Part No.675130)

Asian Vehicle Red 50/50 Ready-to-Use Antifreeze / Coolant, 1 Gallon

from

$22.99
ZEREX Asian Vehicle Antifreeze/Coolant is specifically formulated to meet the requirements of Asian vehicle manufacturers (Toyota®, Lexus®, Scion® and others) requiring a red, silicate free Hybrid Organic Acid Technology (HOAT) with a phosphate additive. This patented formula is designed to replace the original fluid and provides protection from rust, corrosion, boil overs and freezing.

Product Features:
  • Formulated to replace the OEM fluid in Asian make vehicles such as Toyota®, Lexus®, Scion® and others requiring a red, silicate free HOAT antifreeze/coolant
  • Silicate-free, long-life, phosphate Hybrid Organic Acid Technology chemistry
  • The long life formula provides protection for all cooling system metals from rust and corrosion. The silicate free, borate free formula helps protect against harmful scale and deposits
  • Meets the following OEM and industry specifications: JIS K 2234-1994, Hyundai/KIA MS 591-08, Mitsubishi ES-64217, Ford WSS-M97B55-A, ASTM 3306, ASTM D4985, Federal Specification A-A-870A
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Pentosin – Pentofrost A4 HOAT Phosphated Asian 50/50 Prediluted Antifreeze / Coolant – 1 Gallon (Part No.8115209)

Pentofrost A4 HOAT Phosphated Asian 50/50 Prediluted Antifreeze / Coolant - 1 Gallon

from

$24.99
Pentofrost A4 is a phosphated organic acid technology (phosphated OAT); which is categorized as HOAT (hybrid organic acid technology) in the US market. Pentofrost A4 is suitable for all Asian vehicles using pink Antifreeze/Coolant. Pentofrost A4 does not contain any silicate, borate, nitrite or amine containing additives since these may harm your Asian vehicle. Do not mix with other coolants (especially silicated coolants), as this may cause el formation and clog your radiator. Pentofrost A4 is a PRE-DILUTED antifreeze for Asian vehicle applications in water-cooled engines. It contains phosphates and organic salts to protect all materials used in cooling systems for Asian vehicles. Pentofrost A4 is mixable with all phosphated OAT. Meets ASTM D-3306.

Product Features:
  • Manufactured to the OE applications specific formulation.
  • Manufactured to the exact spec of DIN and ASTM D-3306.
  • Protects against corrosion and cavitation.
  • Does not foam.
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Prestone – Antifreeze and Coolant: 50/50 Ready To Use, Universal, Protects Against Corrosion, 1 Gallon (Part No.AF2100)

Antifreeze and Coolant: 50/50 Ready To Use, Universal, Protects Against Corrosion, 1 Gallon

from

$14.99
Prestone All Vehicles antifreeze+coolant (ready to use) is truly designed to work with all vehicles; all makes, models, years & fluid colors. It is designed to work with all new engines while also being backwards compatible improving protection in all older engines. The patented Cor-Guard technology (the best innovation in the category in decades) instantly protects parts from corrosion, buildup, pitting, scaling, rust and other damage. These fluids are specially designed to not only manage the engine temp and protect from freezing up (like competitors), but they also potect the engine from damage. Internal damage can cause engine part failure, leading to expensive repairs and serious inconveniences. Avoid costly repairs and vehicles in the shop with Prestone All Vehicles antifreeze+coolant. This fluid is designed to last 10yrs / 300,000 miles and also to protect the internal parts of the engine for 10yrs / 300,000, offically patented by Prestone.

Product Features:
  • Formulated to work with All Vehicles. Works with all fluid colors; All OAT, POAT, HOAT & IAT.
  • Longer Engine Life Guarantee – 10 Yr., 300,000 mile Extended life formula.
  • Includes patented Prestone CorGuard technology, the best advancement in cooling system parts protection that protects against rust and corrosion of all cooling system metals, including aluminum. Protection for 300,000 miles.
  • Ready to Use formula (prediluted to a 50% Eg & 50% distilled water mix). Perfect for small volume top-off or complete drain and refill of the cooling system
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Prestone – Antifreeze and Coolant: Concentrate, Universal, Protects Against Buildup And Rust, 1 Gallon (Part No.AF2000)

Antifreeze and Coolant: Concentrate, Universal, Protects Against Buildup And Rust, 1 Gallon

from

$17.99
Prestone All Vehicles antifreeze+coolant (concentrate) is truly designed to work with all vehicles; all makes, models, years & fluid colors. It is designed to work with all new engines, while also being backwards compatible improving protection in all old

Product Features:
  • Formulated to work with All Vehicles. Works with all fluid colors; All OAT, POAT, HOAT & IAT.
  • Longer Engine Life Guarantee – 10 Yr., 300,000 mile Extended life formula.
  • Includes patented Prestone CorGuard technology, the best advancement in cooling system parts protection that protects against rust and corrosion of all cooling system metals, including aluminum. Protection for 300,000 miles.
  • Concentrate formula. Must mix with distilled to the desired mix ratio of EG & water. Can be used for top-off, complete drain and refill or flush and refill of the cooling system.
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FRAM – Antifreeze and Coolant: 50/50 Ready To Use, OE North American Gold, 1 Gallon (Part No.F301)

Antifreeze and Coolant: 50/50 Ready To Use, OE North American Gold, 1 Gallon

from

$13.99
Fram Extended Life AMAM Concentrate is compatible with ANY antifreeze/coolant in ANY vehicle with aluminum or other cooling system metals. The formulas have a blend of long-lasting inhibitors to guard against temperature extremes and the effects of rust, corrosion, and premature water pump failure. Prime Concentrate meets or exceeds ASTM D3306 and D4985 for corrosion protection for cars and light duty trucks, while providing reliable freeze-up and boil-over protection.

Product Features:
  • Formulated to work with All Vehicles. Universally works with all fluid colors; All OAT, POAT, HOAT & IAT.
  • 5 Yr., 150,000 mile Extended life formula.
  • Meets or exceeds ASTM D3306 & D4985 for corrosion protection.
  • Concentrated formula. Must mix with high quality (distilled/deionized) water to the desired ratio. Can be used for top-off, complete drain and refill or flush and refill of the cooling system.
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Peak – 10X Antifreeze + Coolant Concentrate for All Vehicles – 1 Gallon (Part No.PKP0B3)

10X Antifreeze + Coolant Concentrate for All Vehicles - 1 Gallon

from

$19.79
PEAK® Antifreeze + Coolant Concentrate is specially engineered to deliver guaranteed superior lifetime protection. Its advanced universal formula contains a proprietary blend of 10X the scale-fighting inhibitors coupled with robust organic additives to fight against the damaging effects of scale deposits and corrosion. PEAK Antifreeze + Coolant is free of 2-EHA, silicate, nitrite, borate, and amines, ensuring maximum cooling system performance for 10+ years/300,000+ miles. It is compatible for use with any color or type of antifreeze/coolant in the system.

Product Features:
  • Specially formulated to deliver Superior Lifetime Protection against damaging scale and corrosion
  • Contains 10X the scale-fighting inhibitors to ensure maximum cooling system performance
  • Provides more than 2X the warranty coverage for 10+ years/300,000+ miles of service
  • Universal formula is compatible with any color or type of antifreeze/coolant
  • Meets the performance requirements of ASTM D3306 and D4985
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FRAM – Antifreeze and Coolant: 50/50 Ready To Use, Universal, Optimizes Engine Temperature, 1 Gallon (Part No.F401)

Antifreeze and Coolant: 50/50 Ready To Use, Universal, Optimizes Engine Temperature, 1 Gallon

from

$10.99
FRAM Extended Life AMAM 50/50 is compatible with ANY antifreeze/coolant in ANY vehicle with aluminum or other cooling system metals. The formulas have a blend of long-lasting inhibitors to guard against temperature extremes and the effects of rust, corrosion, and premature water pump failure. Top-off your cooling system with Prime Extended Life AMAM 50/50, which is a blend of 50% antifreeze and 50% demineralized water. Prime 50/50 meets or exceeds ASTM D3306 and D4985 for corrosion protection for cars and light duty trucks, while providing reliable freeze-up and boil-over protection.

Product Features:
  • Formulated to work with All Vehicles. Universally works with all fluid colors; All OAT, POAT, HOAT & IAT.
  • 5 Yr., 150,000 mile Extended life formula.
  • Meets or exceeds ASTM D3306 & D4985 for corrosion protection.
  • Ready to Use formula (prediluted to a 50% Eg & 50% distilled water mix). Perfect for small volume top-off or complete drain and refill of the cooling system
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Peak – Original Equipment Asian Red/Pink Antifreeze and Coolant: 50/50 Ready To Use, 1 Gallon (Part No.PARB53)

Original Equipment Asian Red/Pink Antifreeze and Coolant: 50/50 Ready To Use, 1 Gallon

from

$19.99
PEAK ORIGINAL EQUIPMENT TECHNOLOGY ANTIFREEZE + COOLANT for ASIAN VEHICLES is a line of premium coolants specifically designed to match the technology and color requirements of Asian vehicles. Each coolant is formulated with the same corrosion inhibitor technology that protected your vehicle straight from the factory. Color cues on the packaging and a list of covered vehicles on the front label make it easy to identify the right match for your specific vehicle. PEAK ORIGINAL EQUIPMENT TECHNOLOGY ANTIFREEZE + COOLANT for ASIAN VEHICLES – RED/PINK is an ethylene glycol-based antifreeze/coolant specifically developed for use in any Asian vehicle requiring a Red or Pink phosphate-enhanced organic acid technology (POAT) formulation. It contains high-quality organic acid corrosion inhibitors and is free of borate, nitrite, silicate and amines chemicals. PEAK ORIGINAL EQUIPMENT TECHNOLOGY ANTIFREEZE + COOLANT for ASIAN VEHICLES – RED/PINK meets the performance requirements of ASTM D3306 and JIS K2234. With a complete flush and fill, PEAK guarantees this coolant will provide service life protection of up to 150,000 miles or 5 years.

Product Features:
  • Matches each Asian vehicle manufacturer’s technology and color requirements
  • Protects all cooling system metals from rust and corrosion
  • Meets the performance requirements of ASTM D3306 and JIS K2234
  • Service life of up to 5 years/150,000 miles with a complete cooling system flush and fill
  • Color-coding and vehicle applications listed on the front simplify selecting the right antifreeze/coolant
  • Available as both concentrate and 50/50 products to do the job right
  • Testing Requirements: For proper freeze and boil over protection, use a traditional refractometer or hydrometer to measure the percentage of ethylene glycol by volume.
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Prestone – Antifreeze and Coolant: 50/50 Ready To Use, Original Equipment Asian Red, 1 Gallon (Part No.AF6200)

Antifreeze and Coolant: 50/50 Ready To Use, Original Equipment Asian Red, 1 Gallon

from

$22.99
Prestone® Asian Vehicles (Red) antifreeze+coolant (AFC) is our MOST ADVANCED TECHNOLOGY specially designed to work with all Toyota, Lexus and Scion vehicles. While ordinary antifreeze coolant only manages 2/3rd the job, the basic freeze and boil points, Prestone’s Superior Protection adds an extra layer that keeps your engine clean from corrosion, rust and buildup. Asian AFC includes our most advanced Cor-Guard® technology, which instantly protects parts from corrosion, buildup, pitting, scaling, rust and other damage compared to ordinary coolants that can’t keep the system clean. Internal damage can cause engine part failure or clogging, leading to expensive repairs and inconveniences. Avoid costly repairs and vehicles in the shop with Prestone Asian Red antifreeze+coolant. Prestone Asian Red AFC Superior Protection guarantee is for 10yrs / 300,000 miles. Year Round Protection – Antifreeze to -34 Deg. F; Antiboil/overheat protection to +265 Deg. F.

Product Features:
  • Specially formulated to work with vehicles using red colored fluid; POAT. All Toyota; All Lexus; All Scion.
  • Superior protection guarantee – 10 Yr., 300,000 mile Extended life formula
  • Includes patented Prestone CorGuard technology, the best advancement in cooling system parts protection that protects against rust and corrosion of all cooling system metals, including aluminum. Protection for 300,000 miles.
  • Ready to Use formula. Perfect for small volume top-off or complete drain and refill of the cooling system.
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Prestone – Antifreeze and Coolant: Concentrate, Universal Platinum, Protects Against Corrosion, 1 Gallon (Part No.AF2500)

Antifreeze and Coolant: Concentrate, Universal Platinum, Protects Against Corrosion, 1 Gallon

from

$22.99
Prestone® Platinum antifreeze+coolant is Prestone’s best universal antifreeze & coolant product. GUARANTEED to work with all vehicles; all makes, models, years & fluid colors. 15+ years, 350,000 miles of protection; the fluid is guaranteed for the life of your vehicle. This advanced product delivers Extreme Protection against both freezing temperatures (-50 Deg. F) and overheating / boiling over of the engine (+268 Deg. F). Prestone Platinum utilizes industry leading protection from engine damaging rust, corrosion, buildup & scale. While ordinary antifreeze coolant only focuses on the basic corrosion coverage, Prestone Platinum goes farther, adding our most advanced cooling sytem protection, allowing the system to run optimally, like when it was new. Internal buildup & corrosion damage can cause engine part failure or clogging, leading to expensive repairs and inconveniences. Prestone Platinum helps you avoid costly repairs and vehicles in the shop. This extended life coolant is guaranteed to work with all new engines and engine technology, while also being backwards compatible, improving protection in all older engines. Prestone Platinum antifreeze+coolant – Year Round Protection.

Product Features:
  • Guaranteed to work with All Vehicles. Universally works with all fluid colors; All OAT, POAT, HOAT & IAT; G05®, G11®, G12®, G12++®, G13®, G30®, G40®, & GG40®. For all engines & engine sizes, new and older engines.
  • 15+ Yr., 350,000 mile Extended life formula. The fluid is guaranteed for the life of your vehicle
  • Includes our most advanced Prestone Cor-Guard® technology, unmatched cooling system parts protection that protects against engine damage; rust, corrosion, scale, build-up and clogging. Protection for 15+yrs / 350,000 miles.
  • Concentrated formula. Must mix with high quality water to the desired ratio. Can be used for top-off, complete drain and refill or flush and refill of the cooling system.
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Prestone – MAX Original Equipment Antifreeze + Coolant: Asian Red/Pink, 50/50 RTU, 1 Gal (Part No.AF6210)

MAX Original Equipment Antifreeze + Coolant: Asian Red/Pink, 50/50 RTU, 1 Gal

from

$20.99
Prestone® MAX antifreeze + coolant uses Advanced Original Equipment Technology to provide MAXIMUM ENGINE PROTECTION for Asian vehicles requiring Red or Pink antifreeze + coolant, guaranteed. Our Advanced Technology formula delivers high performance temperature protection, industry leading protection from engine damaging rust & corrosion and the longest lasting protection in the industry. Trust Prestone – a leading global manufacturer of Original Equipment Antifreeze + Coolant.

Product Features:
  • Can top off or replace any Red or Pink antifreeze + coolant in all Toyota, Lexus & Scion vehicles, guaranteed. 50/50 Ready to Use (RTU) formula.
  • High performance temperature protection from deep winter freezes and scorching summer heat.
  • Industry leading protection from engine damaging rust, corrosion & buildup. Prestone MAX completely stops the formation of rust & corrosion for better engine performance and longer engine life.
  • Prestone Max is guaranteed to protect your vehicle for 15+ years and/or 350,000 miles. It’s the longest fluid life in the industry.
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Prestone – Antifreeze and Coolant: 50/50 Ready To Use, Universal Platinum, 1 Gallon (Part No.AF2550)

Antifreeze and Coolant: 50/50 Ready To Use, Universal Platinum, 1 Gallon

from

$19.99
Prestone® Platinum antifreeze+coolant is Prestone’s best universal antifreeze & coolant product. GUARANTEED to work with all vehicles; all makes, models, years & fluid colors. 15+ years, 350,000 miles of protection; the fluid is guaranteed for the life of your vehicle. This advanced product delivers Extreme Protection against both freezing temperatures (-50 Deg. F) and overheating / boiling over of the engine (+268 Deg. F). Prestone Platinum utilizes industry leading protection from engine damaging rust, corrosion, buildup & scale. While ordinary antifreeze coolant only focuses on the basic corrosion coverage, Prestone Platinum goes farther, adding our most advanced cooling sytem protection, allowing the system to run optimally, like when it was new. Internal buildup & corrosion damage can cause engine part failure or clogging, leading to expensive repairs and inconveniences. Prestone Platinum helps you avoid costly repairs and vehicles in the shop. This extended life coolant is guaranteed to work with all new engines and engine technology, while also being backwards compatible, improving protection in all older engines. Prestone Platinum antifreeze+coolant – Year Round Protection.

Product Features:
  • Guaranteed to work with All Vehicles. Universally works with all fluid colors; All OAT, POAT, HOAT & IAT; G05®, G11®, G12®, G12++®, G13®, G30®, G40®, & GG40®. For all engines & engine sizes, new and older engines.
  • 15+ Yr., 350,000 mile Extended life formula. The fluid is guaranteed for the life of your vehicle
  • Includes our most advanced Prestone Cor-Guard® technology, unmatched cooling system parts protection that protects against engine damage; rust, corrosion, scale, build-up and clogging. Protection for 15+yrs / 350,000 miles.
  • Ready to Use formula – Prediluted 56/54. Perfect for small volume top-off or complete drain and refill of the cooling system
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Prestone – MAX Antifreeze + Coolant: All Vehicles, Concentrate, 1 Gallon (Part No.AF2800)

MAX Antifreeze + Coolant: All Vehicles, Concentrate, 1 Gallon

from

$18.99
All Anitfreeze + Coolants are not the same. Prestone® MAX antifreeze + coolant is GUARANTEED to provide MAXIMUM ENGINE PROTECTION in all Vehicle Makes, Models & Years. It delivers the widest range of temperature protection, industry leading protection from engine damaging rust & corrosion and the longest lasting protection in the industry. Trust Prestone for maximum, year-round engine protection.

Product Features:
  • Can top off or replace all antifreeze + coolant colors and formulations in all Vehcile Makes, Models & Years – Guaranteed.
  • Our patented, advance formula provides extreme temperature protection from the worst of winter deep freezes and scorching summer heat.
  • We deliver industry leading protection from engine damaging rust, corrosion & buildup. Prestone MAX completely stops the formation of rust & corrosion for better engine performance and longer engine life.
  • Prestone Max is guaranteed to protect your vehicle for 15+ years and/or 350,000 miles. It¿s the longest fluid life in the industry.
  • Prestone Max is guaranteed to protect your vehicle for 15+ years and/or 350,000 miles. It┐s the longest fluid life in the industry.
  • This is a Concentrated Formula. Must mix with high quality water to the desired ratio.
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Prestone – MAX Antifreeze + Coolant: All Vehicles, 56/44 Ready to Use, 1 Gallon (Part No.AF2850)

MAX Antifreeze + Coolant: All Vehicles, 56/44 Ready to Use, 1 Gallon

from

$16.99
All Anitfreeze + Coolants are not the same. Prestone® MAX antifreeze + coolant is GUARANTEED to provide MAXIMUM ENGINE PROTECTION in all Vehicle Makes, Models & Years. It delivers the widest range of temperature protection, industry leading protection from engine damaging rust & corrosion and the longest lasting protection in the industry. Trust Prestone for maximum, year-round engine protection.

Product Features:
  • Can top off or replace all antifreeze + coolant colors and formulations in all Vehcile Makes, Models & Years – Guranteed.
  • Our patented, advance formula provides extreme temperature protection from the worst of winter deep freezes and scorching summer heat.
  • We deliver industry leading protection from engine damaging rust, corrosion & buildup. Prestone MAX completely stops the formation of rust & corrosion for better engine performance and longer engine life.
  • Prestone Max is guaranteed to protect your vehicle for 15+ years and/or 350,000 miles. It¿s the longest fluid life in the industry.
  • Prestone Max is guaranteed to protect your vehicle for 15+ years and/or 350,000 miles. It┐s the longest fluid life in the industry.
  • This is a Ready to Use formula – prediluted 56/44.
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FAQs for 2021 Lexus IS350 Engine Coolant and Antifreeze

What are the most popular Engine Coolant and Antifreeze for the 2021 Lexus IS350?

With 5 brands you can trust, our most popular Engine Coolant and Antifreeze for the 2021 Lexus IS350 parts are:
Antifreeze and Coolant: 50/50 Ready To Use, Universal, Protects Against Corrosion, 1 Gallon
from $14.99
This product is not rated
Antifreeze and Coolant: 50/50 Ready To Use, Universal, Protects Against Corrosion, 1 Gallon
Engine Coolant and Antifreeze
Antifreeze and Coolant: Concentrate, Universal, Protects Against Buildup And Rust, 1 Gallon
from $17.99
This product is not rated
Antifreeze and Coolant: Concentrate, Universal, Protects Against Buildup And Rust, 1 Gallon
Engine Coolant and Antifreeze
Asian Vehicle Red 50/50 Ready-to-Use Antifreeze / Coolant, 1 Gallon
from $22.99
(241)
Asian Vehicle Red 50/50 Ready-to-Use Antifreeze / Coolant, 1 Gallon
Engine Coolant and Antifreeze

What are the best aftermarket Engine Coolant and Antifreeze for the 2021 Lexus IS350?

See what past customers had to say about our highest-rated Engine Coolant and Antifreeze for the 2021 Lexus IS350: