2021 Lexus IS350 Differentials

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Keep Your 2021 Lexus IS350 in Top Shape with Quality Differentials

Whether you’re repairing or upgrading your Differential, using high-quality parts is key to keeping your 2021 Lexus IS350 looking sharp and performing at its best. At Advance Auto Parts we carry a wide selection of dependable options, including Differential Drain Plugs and Differential Oil. Whether you’re replacing a damaged part or enhancing your truck’s style and protection, you’ll find exactly what you need to get the job done right.

Competitive Prices and Extensive Inventory

The average price for a 2021 Lexus IS350 Differential at Advance Auto Parts is around $18.82, with a range that starts at $8.79 and goes up to $35.99. With 4 options in stock from 2 trusted brands, finding the right fit is easy. Popular picks like Valvoline Extended Protection Full Synthetic Automatic Transmission Fluid ATF 1 QT, 904976, Valvoline Multi-Vehicle (ATF) Full Synthetic Automatic Transmission Fluid 1 GA, 904891, and Dorman Magnetic Differential Plug – Direct replacement (Sold by each), 991-000 start at just $8.79 and offer a great balance of form and function.

Explore Related Parts

While you’re upgrading or replacing your Differential, don’t forget to check out other key components like Drive Shafts and Axles and Spindles. At Advance Auto Parts, we’re here to help you keep your 2021 Lexus IS350 in peak condition, inside and out.

Essential 2021 Lexus IS350 Differentials

Dorman – Dorman Magnetic Differential Plug, 991-000CD (Part No.991-000CD)

Dorman Magnetic Differential Plug, 991-000CD

from

$14.49
This differential oil drain plug is designed to match the fit and function of a missing or damaged original equipment plug on specified vehicles and positions. It is engineered to replace a missing or damaged plug and help ensure a secure seal.
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Dorman – Dorman Magnetic Differential Plug – Direct replacement (Sold by each), 991-000 (Part No.991-000)

Dorman Magnetic Differential Plug - Direct replacement (Sold by each), 991-000

from

$8.79
This differential oil drain plug is designed to match the fit and function of a missing or damaged original equipment plug on specified vehicles and positions. It is engineered to replace a missing or damaged plug and help ensure a secure seal.
See More

Valvoline – Valvoline Extended Protection Full Synthetic Automatic Transmission Fluid ATF 1 QT, 904976 (Part No.904976)

Valvoline Extended Protection Full Synthetic Automatic Transmission Fluid ATF 1 QT, 904976

from

$15.99
Modern transmissions are better than ever, with more gears to help improve fuel efficiency and acceleration. Greater performance calls for greater protection. Valvoline Extended Protection Full Synthetic ATF features our exclusive Dual Defense Additive Technology for two layers of protection against metal-on-metal contact and thermal breakdown, all while minimizing wear on clutch components. In fact, Valvoline Extended Protection Full Synthetic ATF is 45% stronger against breakdown compared to major brand DEX/MERC oxidative PDSC performance. Proven to maximize transmission life, our patented formula keeps your modern vehicle shifting smoothly, mile after mile, with the ultimate protection you can only expect from Valvoline, the #1 ATF brand.
See More

Valvoline – Valvoline Multi-Vehicle (ATF) Full Synthetic Automatic Transmission Fluid 1 GA, 904891 (Part No.904891)

Valvoline Multi-Vehicle (ATF) Full Synthetic Automatic Transmission Fluid 1 GA, 904891

from

$35.99
Choosing an automatic transmission fluid just got easier. Valvoline Full Synthetic MaxLife Multi-Vehicle ATF, the #1 ATF product, is suitable for use in 95% of ATF vehicles in operation with US registered light duty applications. And now, it€™s also recommended for most belt and chain-driven continuously variable transmissions (CVT). Featuring advanced additives to prevent the major causes of transmission breakdown, it€™s designed to help prevent leaks, reduce wear and tear, and maximize performance €“ all for much longer than conventional fluids. It has improved thermal stability for longer fluid life, better viscosity stability for consistent transmission operation, and frictional enhancements for smooth gear engagements. Whether your vehicle has a CVT or traditional automatic, Valvoline MaxLife Multi-Vehicle ATF is suitable for a broad range of transmissions including Ford, GM, Toyota, Honda, Nissan, Hyundai, Subaru, BMW, Mercedes, Volvo, VW and Audi vehicles. It€™s specifically recommended for use in the following applications: GM DEXRON-II, DEXRON-III, DEXRON-VI, and DEX-CVT; Ford MERCON LV; Toyota/Lexus Type T, T-II, T-IV, WS, CVTF FE, and CVTF TC. For the many miles ahead, trust your transmission with Valvoline, the #1 automatic transmission fluid brand.
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Most Popular Differential Drain Plugs for 2021 Lexus IS350s

Enhance your 2021 Lexus IS350 with one of the 2 Differential Drain Plugs we have in stock, starting at just $8.79.

Dorman – Dorman Magnetic Differential Plug, 991-000CD (Part No.991-000CD)

Dorman Magnetic Differential Plug, 991-000CD

from

$14.49
This differential oil drain plug is designed to match the fit and function of a missing or damaged original equipment plug on specified vehicles and positions. It is engineered to replace a missing or damaged plug and help ensure a secure seal.
See More

Dorman – Dorman Magnetic Differential Plug – Direct replacement (Sold by each), 991-000 (Part No.991-000)

Dorman Magnetic Differential Plug - Direct replacement (Sold by each), 991-000

from

$8.79
This differential oil drain plug is designed to match the fit and function of a missing or damaged original equipment plug on specified vehicles and positions. It is engineered to replace a missing or damaged plug and help ensure a secure seal.
See More

Best-Selling 2021 Lexus IS350 Differential Oil

Upgrade your IS350 with one of our 2 best-selling Differential Oil.

Valvoline – Valvoline Multi-Vehicle (ATF) Full Synthetic Automatic Transmission Fluid 1 GA, 904891 (Part No.904891)

Valvoline Multi-Vehicle (ATF) Full Synthetic Automatic Transmission Fluid 1 GA, 904891

from

$35.99
Choosing an automatic transmission fluid just got easier. Valvoline Full Synthetic MaxLife Multi-Vehicle ATF, the #1 ATF product, is suitable for use in 95% of ATF vehicles in operation with US registered light duty applications. And now, it€™s also recommended for most belt and chain-driven continuously variable transmissions (CVT). Featuring advanced additives to prevent the major causes of transmission breakdown, it€™s designed to help prevent leaks, reduce wear and tear, and maximize performance €“ all for much longer than conventional fluids. It has improved thermal stability for longer fluid life, better viscosity stability for consistent transmission operation, and frictional enhancements for smooth gear engagements. Whether your vehicle has a CVT or traditional automatic, Valvoline MaxLife Multi-Vehicle ATF is suitable for a broad range of transmissions including Ford, GM, Toyota, Honda, Nissan, Hyundai, Subaru, BMW, Mercedes, Volvo, VW and Audi vehicles. It€™s specifically recommended for use in the following applications: GM DEXRON-II, DEXRON-III, DEXRON-VI, and DEX-CVT; Ford MERCON LV; Toyota/Lexus Type T, T-II, T-IV, WS, CVTF FE, and CVTF TC. For the many miles ahead, trust your transmission with Valvoline, the #1 automatic transmission fluid brand.
See More

Valvoline – Valvoline Extended Protection Full Synthetic Automatic Transmission Fluid ATF 1 QT, 904976 (Part No.904976)

Valvoline Extended Protection Full Synthetic Automatic Transmission Fluid ATF 1 QT, 904976

from

$15.99
Modern transmissions are better than ever, with more gears to help improve fuel efficiency and acceleration. Greater performance calls for greater protection. Valvoline Extended Protection Full Synthetic ATF features our exclusive Dual Defense Additive Technology for two layers of protection against metal-on-metal contact and thermal breakdown, all while minimizing wear on clutch components. In fact, Valvoline Extended Protection Full Synthetic ATF is 45% stronger against breakdown compared to major brand DEX/MERC oxidative PDSC performance. Proven to maximize transmission life, our patented formula keeps your modern vehicle shifting smoothly, mile after mile, with the ultimate protection you can only expect from Valvoline, the #1 ATF brand.
See More

FAQs for 2021 Lexus IS350 Differentials

What are the best-selling Differentials for 2021 Lexus IS350s?

What’s the price range for 2021 Lexus IS350 Differentials?

The prices of Differentials for the 2021 Lexus IS350 range from $8.79 up to $35.99 for the most premium parts.

What is the average price of a Differential for a 2021 Lexus IS350?

The average price for Differentials for the 2021 Lexus IS350 is $18.82. Keep in mind the variety of part types within our Differential category, where you are likely to find a wide range of prices across a variety of parts and components.

Does Advance Auto Parts sell Differentials for other Lexus IS350 model years?

Yes, we carry Differentials for 19 model years of Lexus IS350s between 2006 and 2026. The following model years are the most popular for Differential purchases: 2023, 2022, 2020, 2019, 2018, 2017, 2016, 2015, and 2014.

What are the cheapest Differentials for my 2021 Lexus IS350?

Does Advance Auto Parts sell Differentials for any other 2021 Lexus models?

Yes. We stock Differentials for 11 other popular 2021 Lexus models. Some of the most popular are 2021 ES350 Differentials, 2021 RX350 Differentials, 2021 GX460 Differentials, 2021 IS300 Differentials, and 2021 RX450h Differentials.

What types of Differentials do you sell for my 2021 Lexus IS350?

As of 8/2/26, these are some of the most in-demand types of Differentials for a 2021 Lexus IS350:

Can I get help with 2021 Lexus IS350 Differential orders?

Contact our customer support team by chat or phone, through the help desk page, where you can find instant answers about Lexus Differentials and more.

What is your return policy for Lexus IS350 Differentials?

Advance Auto Parts keeps returns simple. For new Lexus IS350 Differentials and accessories, your online orders can be returned, in their original condition, within 45 days. For requirements, see the returns page.