2021 GMC Sierra 3500 HD Engine Cooling Parts

Keep Your 2021 GMC Sierra 3500 HD in Top Shape with Quality Engine Cooling Parts

Whether you’re repairing or upgrading your Engine Cooling Part, using high-quality parts is key to keeping your 2021 GMC Sierra 3500 HD looking sharp and performing at its best. At Advance Auto Parts we carry a wide selection of dependable options, including Radiator Caps, Thermostats, and Water Pump Gaskets. Whether you’re replacing a damaged part or enhancing your truck’s style and protection, you’ll find exactly what you need to get the job done right.

Top-Rated Engine Cooling Parts from Trusted Brands

Looking for a reliable Engine Cooling Part? We’ve got you covered with options from brands you know and trust like Carquest Premium, Dorman, and Motorad. For example, Carquest Premium Engine Cooling Parts start at just $21.99 with an average 4.4 star rating. Dorman and Motorad offer similar pricing and quality, backed by strong customer feedback. With over 374 reviews and a solid 5 star average, you can shop with confidence knowing other GMC Sierra 3500 HD owners approve.

Competitive Prices and Extensive Inventory

The average price for a 2021 GMC Sierra 3500 HD Engine Cooling Part at Advance Auto Parts is around $59.58, with a range that starts at $8.99 and goes up to $809.99. With 22 options in stock from 6 trusted brands, finding the right fit is easy. Popular picks like Standard Thermostat: With Seals, 180, 185 Degrees, Radiator Cap: 20 PSI, and Engine Coolant Reservoir Cap: Twist, Plastic, 1 Pack start at just $17.99 and offer a great balance of form and function.

Explore Related Parts

While you’re upgrading or replacing your Engine Cooling Part, don’t forget to check out other key components like Air Conditioning Parts and Blower Motor and Related Products. At Advance Auto Parts, we’re here to help you keep your 2021 GMC Sierra 3500 HD in peak condition, inside and out.

Essential 2021 GMC Sierra 3500 HD Engine Cooling Parts

Dorman – Help – Engine Coolant Reservoir Cap: Twist, Plastic, 1 Pack (Part No.54218)

Engine Coolant Reservoir Cap: Twist, Plastic, 1 Pack

from

$17.99
Cracked or lost the original engine coolant reservoir cap? Replace it seamlessly and effectively with this precisely engineered, direct replacement cap.

Product Features:
  • Direct replacement – this engine coolant reservoir cap directly replaces a cracked or lost original cap
  • Application specific – made to match dimensions of reservoir cap on only certain vehicle years, makes and models
  • Seamless fit – reverse-engineered from the original equipment to fit perfectly
  • Excellent value – a quick, easy replacement that’s less expensive than going back to the dealership
See More

Carquest Premium – Radiator Cap: 15 PSI (Part No.10248)

Radiator Cap: 15 PSI

from

$15.99
Crafted to meet the exact specifications set by Original Equipment Manufacturers (OEM), these products are engineered for effortless installation and removal. Constructed from premium-grade components, incorporating proper relief and vacuum valves, they ensure optimal performance even in the most demanding automotive cooling systems. Rigorously quality-tested, these components provide exceptional, out-of-the-box performance and superior durability to meet or exceed the highest standards of today’s vehicles.

Product Features:
  • Maintains proper cooling system pressure
  • Easy installation and removal
  • 100% tested to ensure proper pressure and longevity
  • Meets all OEM specifications
See More

Felpro – Engine Water Pump Gasket (Part No.36110)

Engine Water Pump Gasket

from

$9.49
Fel-Pro gaskets are specifically designed for the repair environment to deliver a reliable seal on even the most troublesome applications. Designed for imperfect sealing surfaces and manufactured with proprietary materials, you can count on Fel-Pro for innovative sealing solutions for the real-world repair environment.

Product Features:
  • Meets or exceeds all original equipment specifications
  • Application specific design
  • Manufactured for the sealing repair environment
  • Validated for fit, form, and function
  • Quality that you can trust
See More

Felpro – Engine Water Pump Gasket (Part No.35635)

Engine Water Pump Gasket

from

$7.49
Fel-Pro gaskets are specifically designed for the repair environment to deliver a reliable seal on even the most troublesome applications. Designed for imperfect sealing surfaces and manufactured with proprietary materials, you can count on Fel-Pro for innovative sealing solutions for the real-world repair environment.

Product Features:
  • Meets or exceeds all original equipment specifications
  • Application specific design
  • Manufactured for the sealing repair environment
  • Validated for fit, form, and function
  • Quality that you can trust
See More

GM Genuine Parts – Water Inlet Seal (Part No.12587397)

Water Inlet Seal

from

$8.99
GM Genuine Parts Engine Coolant Thermostat Seals are designed, engineered, and tested to rigorous standards, and are backed by General Motors. These seals help close and prevent coolant from leaking out of your vehicle’s cooling system components. GM Genuine Parts are the true OE parts installed during the production of or validated by General Motors for GM vehicles. Some GM Genuine Parts may have formerly appeared as ACDelco GM Original Equipment (OE).

Product Features:
  • Helps close and prevent coolant from leaking out of your vehicle’s cooling system components to maintain the proper engine temperature
  • Some GM Genuine Parts may have formerly appeared as ACDelco GM Original Equipment (OE)
  • GM Genuine Parts are designed, engineered and tested to rigorous standards, and are backed by General Motors
  • GM Engineers design and validate OE parts specifically for your Chevrolet, Buick, GMC, or Cadillac vehicle
  • GM regularly updates production and service part designs to integrate new materials and technologies
See More

Motorad – Coolant Housing/Water Outlet (Part No.CH6007)

Coolant Housing/Water Outlet

from

$81.99
Manufactured to the highest OEM quality standards by an OE Supplier, using proprietary material to stand up to even the most demanding automotive cooling systems. Thermal shock validated and 100% leak tested Meets or exceeds all OEM standards.

Product Features:
  • Easy, one step fit and installation
  • No special tools required
  • Meets or exceeds all OEM standards
See More

Carquest Premium – Coolant Housing/Water Outlet (Part No.85945)

Coolant Housing/Water Outlet

from

$20.99
We are proud to offer this CARQUEST product line: CARQUEST Water Outlets. Our products are engineered and tested to provide years of trouble free operation and designed to be hassle free OE replacement part that meets and/or exceeds OE standards. Backed by over 50 years of mobile temperature control experience, fix it once and fix it right with CARQUST Water Outlets and Thermostat Housings.

Product Features:
  • Meets and/or exceeds OEM standard
  • Includes quality gasket or O-ring to ensure proper seal (where applicable)
  • 100% leak tested
  • Direct-fit replacement for ease of installation
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KAI – Radiator (Part No.RAD13029)

Radiator

from

$232.99
New Platinum Pro Radiator, 34 Inch Core With Engine And Transmission Oil Coolers

Product Features:
  • 34 Inch Core With Engine Oil Cooler And TOC, Without Heavy Duty Cooling, Made Of Plastic and Aluminum
  • Meets All Federal Motor Safety Standards
  • No Drilling Needed For Installation
  • No Modifications Needed For Installation
  • Direct Fit Replacement For Your Vehicle
  • Same Form Fit And Function As OE
  • Radiator Cap Not Included
  • Check Out The Large Selection Of Parts Available For Your Vehicle
See More

CSF Cooling – Core Dimensions 22.75"W X 34" L X 7/8"D, Crossflow, Aluminum (Part No.3798)

Core Dimensions 22.75"W X 34" L X 7/8"D, Crossflow, Aluminum

from

$255.99
CSF Radiators are designed and built to High Performance Standards. Radiators are carefully engineered and Wind Tunnel Tested in laboratory for Cooling Performance Validation. We have over 10,000 different models of Radiators that we manufacture and supply for all the leading brands of vehicles on the road.

Product Features:
  • OEM Specified Plastic Tank-Aluminum Core Construction
  • Tanks Are Made From Virgin Grade Engineered Plastic Resins, Which Are Glass Filled For Added Strength And Durability
  • Gaskets Are Made From Special Grade EPDM Rubber To Withstand Extreme Temperatures Of Up To -120 Degrees Fahrenheit
  • Tubes – Welded Type Or Latest Generation B-Tube Design
  • Fins High Performance Multi-Louvered Design OEM Spec
  • 100 Percent Leak Tested Before Leaving Factory At 150 Percent Of Operating Pressure
  • High Performance Transmission Cooler With Special Built-In Turburlator, When Applicable
  • Drop In Fit
  • All Components Are Installed, Torqued, And Tested On Radiator During Assembly
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Dorman – Water Pump Outlet Pipe (Part No.626-661)

Water Pump Outlet Pipe

from

$82.99
This engine coolant pipe is designed to match the fit and function of the original pipe on specified vehicles. It is engineered to help ensure leak-free coolant transfer when an original pipe has failed from heat or corrosion.

Product Features:
  • Direct replacement – this engine coolant pipe is designed to match the fit and function of the original pipe on specified vehicles
  • Ideal solution – engineered to help ensure leak-free coolant transfer when an original pipe has failed from heat or corrosion
  • Durable construction – designed and manufactured to strict specifications for reliable performance
  • Trustworthy quality – backed by a team of product experts in the United States and more than a century of automotive experience
See More

Carquest Premium – Universal Fan Clutch (Part No.216023)

Universal Fan Clutch

from

$94.99
Product Features:
  • Designed, tested, and built by application
  • OE performance, fit, and appearance
  • Precision machined
  • Out of box installation
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Carquest Premium – Universal Fan Clutch (Part No.216104)

Universal Fan Clutch

from

$417.99
Product Features:
  • Designed, tested, and built by application
  • OE performance, fit, and appearance
  • Precision machined
  • Out of box installation
See More

Felpro – Engine Water Pump Gasket (Part No.36109)

Engine Water Pump Gasket

from

$19.49
Fel-Pro gaskets are specifically designed for the repair environment to deliver a reliable seal on even the most troublesome applications. Designed for imperfect sealing surfaces and manufactured with proprietary materials, you can count on Fel-Pro for innovative sealing solutions for the real-world repair environment.

Product Features:
  • Meets or exceeds all original equipment specifications
  • Application specific design
  • Manufactured for the sealing repair environment
  • Validated for fit, form, and function
  • Quality that you can trust
See More

Carquest Premium – Standard Thermostat: With Seal, 185 Degrees (Part No.14728)

Standard Thermostat: With Seal, 185 Degrees

from

$43.99
Carquest Premium Thermostats are manufactured with OEM quality materials and safety standards by an OE Supplier. This thermostat will meet and exceed the expectations of the OE thermostat to insure the best product for your cooling system. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant. Offset design, air relief valve, and OEM style seals included where applicable.

Product Features:
  • High grade stainless steel and copper construction
  • Meets or exceeds OEM standards
  • Consistent and precise response to cooling system needs
  • Original equipment design for worry-free direct fit replacement
  • 100% tested and calibrated
See More

Carquest Premium – Standard Thermostat: With Seal, 180 Degrees (Part No.14738)

Standard Thermostat: With Seal, 180 Degrees

from

$42.99
Carquest Premium Thermostats are manufactured with OEM quality materials and safety standards by an OE Supplier. This thermostat will meet and exceed the expectations of the OE thermostat to insure the best product for your cooling system. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant. Offset design, air relief valve, and OEM style seals included where applicable.

Product Features:
  • High grade stainless steel and copper construction
  • Meets or exceeds OEM standards
  • Consistent and precise response to cooling system needs
  • Original equipment design for worry-free direct fit replacement
  • 100% tested and calibrated
See More

GM Genuine Parts – Parking Light Relay (Part No.D1777C)

Parking Light Relay

from

$11.49
GM Genuine Parts Wiring Relays are designed, engineered, and tested to rigorous standards, and are backed by General Motors. These relays help connect or disconnect power to a vehicle accessory when it receives a low voltage signal from a switch. GM Genuine Parts are the true OE parts installed during the production of or validated by General Motors for GM vehicles. Some GM Genuine Parts may have formerly appeared as ACDelco GM Original Equipment (OE).

Product Features:
  • Helps connect or disconnect power to vehicle accessories
  • Some GM Genuine Parts may have formerly appeared as ACDelco GM Original Equipment (OE)
  • GM Genuine Parts are designed, engineered and tested to rigorous standards, and are backed by General Motors
  • GM Engineers design and validate OE parts specifically for your Chevrolet, Buick, GMC, or Cadillac vehicle
  • GM regularly updates production and service part designs to integrate new materials and technologies
See More

Carquest Premium – Radiator Cap: 20 PSI (Part No.10271)

Radiator Cap: 20 PSI

from

$21.99
Crafted to meet the exact specifications set by Original Equipment Manufacturers (OEM), these products are engineered for effortless installation and removal. Constructed from premium-grade components, incorporating proper relief and vacuum valves, they ensure optimal performance even in the most demanding automotive cooling systems. Rigorously quality-tested, these components provide exceptional, out-of-the-box performance and superior durability to meet or exceed the highest standards of today’s vehicles.

Product Features:
  • Maintains proper cooling system pressure
  • Easy installation and removal
  • 100% tested to ensure proper pressure and longevity
  • Meets all OEM specifications
See More

Dorman – Clutch Fan Blade: Plastic, Cost Effective and Reliable (Part No.621-106)

Clutch Fan Blade: Plastic, Cost Effective and Reliable

from

$139.99
Replace your damaged cooling fan blade with this direct replacement. This vehicle-specific application is engineered for a perfect fit and is made from quality materials to ensure durability and restore proper cooling system operation.

Product Features:
  • Direct replacement – this engine cooling fan blade fits and functions like the original equipment fan blade
  • Quality construction – manufactured from premium materials for a long service life
  • Excellent value – original equipment quality at a lower price
  • Quality tested – has undergone testing to ensure proper fit and performance
See More

Dorman – Clutch Fan Blade: Plastic, Cost Effective and Reliable (Part No.621-111)

Clutch Fan Blade: Plastic, Cost Effective and Reliable

from

$134.99
Replace your damaged cooling fan blade with this direct replacement. This vehicle-specific application is engineered for a perfect fit and is made from quality materials to ensure durability and restore proper cooling system operation.

Product Features:
  • Direct replacement – this engine cooling fan blade fits and functions like the original equipment fan blade
  • Quality construction – manufactured from premium materials for a long service life
  • Excellent value – original equipment quality at a lower price
  • Quality tested – has undergone testing to ensure proper fit and performance
See More

Dorman – Clutch Fan Blade: Plastic, Cost Effective and Reliable (Part No.621-104)

Clutch Fan Blade: Plastic, Cost Effective and Reliable

from

$71.99
Replace your damaged cooling fan blade with this direct replacement. This vehicle-specific application is engineered for a perfect fit and is made from quality materials to ensure durability and restore proper cooling system operation.

Product Features:
  • Direct replacement – this engine cooling fan blade fits and functions like the original equipment fan blade
  • Quality construction – manufactured from premium materials for a long service life
  • Excellent value – original equipment quality at a lower price
  • Quality tested – has undergone testing to ensure proper fit and performance
See More

ACDelco – Engine Coolant Temperature Sensor (Part No.213-4514)

Engine Coolant Temperature Sensor

from

$38.99
ACDelco Professional Engine Coolant Temperature Sensor is a high quality aftermarket replacement component for one or more of the following vehicle systems: ignition, and/or engine fuel management. This premium aftermarket sensor is manufactured to meet or exceed your expectations for fit, form, and function.

Product Features:
  • Professional, premium aftermarket replacement
  • Provides the performance and dependability you expect from ACDelco
  • Manufactured to meet expectations for fit, form, and function
See More

NTK – Engine Coolant Temperature Sensor (Part No.EF0173)

Engine Coolant Temperature Sensor

from

$34.99
The Engine Coolant Temperature Sensor determines the exact temperature of the engine coolant by sending an analog signal to the ECM to ensure proper air/fuel ratio along with proper operation of the cooling fans and temperature gauge. The Engine Coolant Temperature Sensor may be located on the cylinder head, engine block, thermostat housing or intake manifold. Reasons for replacement include, check engine light illumination, erratic or no temperature gauge operation, erratic or no cooling fan operation, and engine overheating.

Product Features:
  • OE MATCHED: Wires and probe length match OE. Mounting clips included where applicable
  • FASTER RESPONSE TIME: Thermal conductive grease inside brass housing increases sensor response time
  • THE DIFFERENCE: Thread sealant/o-ring installed where applicable. Thermistor placement within the housing matches OE to ensure proper output. Proper thermal conductive grease to provide accurate temperature transfer to the thermistor
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Carquest Premium – Coolant Temperature Sensor 1TS1001 (Part No.WTC1002)

Coolant Temperature Sensor 1TS1001

from

$19.99
Product Features:
  • Designed to meet or exceed OE specifications for fit, form and function
  • 100% factory resistance calibrated to ensure precision tolerances, resulting in extremely accurate temperature for optimal performance
  • OE precision matched thermistor ensuring Carquest sensors match OE output resistances across all temperature positions
  • O-rings, seals or thread sealant are included if required
  • Weather-tight connectors prevent leaks and corrosion for longer life
  • Extensive design validation testing and 100% end-of-line tested
  • Carquest Vehicle Solutions Technical Support available from ASE certified technicians: 1-866-687-5413
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Dorman – Coolant Temperature Sensor (Part No.926-016)

Coolant Temperature Sensor

from

$24.99
This engine coolant temperature sensor is designed to match the fit and function of the original sensor on specified vehicles, and is engineered for durability and reliable performance.

Product Features:
  • Direct replacement – this engine coolant temperature sensor is designed to match the fit and function of the original sensor on specified vehicles
  • Ideal solution – this sensor is a reliable replacement for an original part that has failed due to fatigue or electrical malfunction
  • Durable construction – this sensor is made from quality components to ensure reliable performance and a long service life
  • Trustworthy quality – backed by team of product experts in the United States and more than a century of automotive experience
See More

Carquest Premium – Radiator Cap Tester Adapter (Part No.12033)

Radiator Cap Tester Adapter

from

$95.99
Tester adapter for the MT-300 cooling system pressure testers. Professional grade test equipment to ensure an automotive cooling system is operating at the correct pressure. Made from high quality materials to ensure durability. Designed to test automotive coolant caps.

Product Features:
  • Machined metal construction
  • Works with MT-300 pressure tester
  • Tests coolant caps
  • Professional quality
See More

Most Popular Radiator Cap for 2021 GMC Sierra 3500 HDs

Enhance your 2021 GMC Sierra 3500 HD with this popular Radiator Cap we have in stock, for $21.99.

Carquest Premium – Radiator Cap: 20 PSI (Part No.10271)

Radiator Cap: 20 PSI

from

$21.99
Crafted to meet the exact specifications set by Original Equipment Manufacturers (OEM), these products are engineered for effortless installation and removal. Constructed from premium-grade components, incorporating proper relief and vacuum valves, they ensure optimal performance even in the most demanding automotive cooling systems. Rigorously quality-tested, these components provide exceptional, out-of-the-box performance and superior durability to meet or exceed the highest standards of today’s vehicles.

Product Features:
  • Maintains proper cooling system pressure
  • Easy installation and removal
  • 100% tested to ensure proper pressure and longevity
  • Meets all OEM specifications
See More

Best-Selling 2021 GMC Sierra 3500 HD Thermostats

Upgrade your Sierra 3500 HD with one of our 6 best-selling Thermostats, earning an average 4.5 stars rating across 62 reviews.

Motorad – Standard Thermostat: With Seals, 180, 185 Degrees (Part No.447448)

Standard Thermostat: With Seals, 180, 185 Degrees

from

$46.99
Manufactured with OEM quality materials and safety standards by an OE Supplier. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant. Offset design, air relief valve, and OEM style seals included where applicable.

Product Features:
  • High grade stainless steel and copper construction
  • Meets or exceeds OEM standards
  • Consistent and precise response to cooling system needs
  • Original equipment design for worry-free direct fit replacement
  • 100% tested and calibrated
See More

Carquest Premium – Standard Thermostat: With Seal, 185 Degrees (Part No.14728)

Standard Thermostat: With Seal, 185 Degrees

from

$43.99
Carquest Premium Thermostats are manufactured with OEM quality materials and safety standards by an OE Supplier. This thermostat will meet and exceed the expectations of the OE thermostat to insure the best product for your cooling system. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant. Offset design, air relief valve, and OEM style seals included where applicable.

Product Features:
  • High grade stainless steel and copper construction
  • Meets or exceeds OEM standards
  • Consistent and precise response to cooling system needs
  • Original equipment design for worry-free direct fit replacement
  • 100% tested and calibrated
See More

Carquest Premium – Standard Thermostat: With Seal, 180 Degrees (Part No.14738)

Standard Thermostat: With Seal, 180 Degrees

from

$42.99
Carquest Premium Thermostats are manufactured with OEM quality materials and safety standards by an OE Supplier. This thermostat will meet and exceed the expectations of the OE thermostat to insure the best product for your cooling system. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant. Offset design, air relief valve, and OEM style seals included where applicable.

Product Features:
  • High grade stainless steel and copper construction
  • Meets or exceeds OEM standards
  • Consistent and precise response to cooling system needs
  • Original equipment design for worry-free direct fit replacement
  • 100% tested and calibrated
See More

Carquest Premium – Standard Thermostat: With Seal, 187 Degrees (Part No.15158)

Standard Thermostat: With Seal, 187 Degrees

from

$34.99
Carquest Premium Thermostats are manufactured with OEM quality materials and safety standards by an OE Supplier. This thermostat will meet and exceed the expectations of the OE thermostat to insure the best product for your cooling system. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant. Offset design, air relief valve, and OEM style seals included where applicable.

Product Features:
  • High grade stainless steel and copper construction
  • Meets or exceeds OEM standards
  • Consistent and precise response to cooling system needs
  • Original equipment design for worry-free direct fit replacement
  • 100% tested and calibrated
See More

Motorad UltraStats – UltraStat Thermostat – 187 Degrees (Part No.5523-187)

UltraStat Thermostat - 187 Degrees

from

$60.99
UltraStat Thermostats are the toughest thermostats on the market. All heavy gauge stainless steel construction provides long-life durability, as well as complete corrosion resitance. Exclusive BLVT Valve technology minimizes thermal shock to cooling system components.

Product Features:
  • Heavy gauge stainless steel components offer increased reliability and long-lasting durability
  • Exclusive BLVT Valve Technology minimizes thermal shock to cooling system components
  • Stainless steel thermal element for unmatched corrosion resistance and revolutionary REAX wax mixture provides quicker reaction time
  • AccuSpring Design for stable temperature control and increased cabin comfort
See More

Motorad UltraStats – UltraStat Thermostat – 160 Degrees (Part No.5523-160)

UltraStat Thermostat - 160 Degrees

from

$60.99
UltraStat Thermostats are the toughest thermostats on the market. All heavy gauge stainless steel construction provides long-life durability, as well as complete corrosion resitance. Exclusive BLVT Valve technology minimizes thermal shock to cooling system components.

Product Features:
  • Heavy gauge stainless steel components offer increased reliability and long-lasting durability
  • Exclusive BLVT Valve Technology minimizes thermal shock to cooling system components
  • Stainless steel thermal element for unmatched corrosion resistance and revolutionary REAX wax mixture provides quicker reaction time
  • AccuSpring Design for stable temperature control and increased cabin comfort
See More

Top-Quality Water Pump Gaskets for 2021 GMC Sierra 3500 HDs

Choose a high-quality OEM or aftermarket Water Pump Gasket for GMC Sierra 3500 HDs and enjoy top-notch performance from $9.49.

Felpro – Engine Water Pump Gasket (Part No.36110)

Engine Water Pump Gasket

from

$9.49
Fel-Pro gaskets are specifically designed for the repair environment to deliver a reliable seal on even the most troublesome applications. Designed for imperfect sealing surfaces and manufactured with proprietary materials, you can count on Fel-Pro for innovative sealing solutions for the real-world repair environment.

Product Features:
  • Meets or exceeds all original equipment specifications
  • Application specific design
  • Manufactured for the sealing repair environment
  • Validated for fit, form, and function
  • Quality that you can trust
See More

Our Top Pick for a 2021 GMC Sierra 3500 HD Radiator

Invest in a durable Radiator for your 2021 GMC, knowing you’re getting trusted brands and expert craftsmanship.

Carquest Premium – Radiator (Part No.4113879)

Radiator

from

$809.99
Reach Radiators offer one of the largest product ranges in the aftermarket, covering more than 95% of the popular automotive and light truck applications. Reach Radiators meet or exceed original equipment specifications, ensuring that products fit and perform just as well or better than the original parts, providing you peace of mind.
See More

Top-Rated Coolant Reservoir Caps for 2021 GMC Sierra 3500 HDs

Make a smart move for your 2021 GMC Sierra 3500 HD with products all priced from $17.99.

Dorman – Help – Engine Coolant Reservoir Cap: Twist, Plastic, 1 Pack (Part No.54218)

Engine Coolant Reservoir Cap: Twist, Plastic, 1 Pack

from

$17.99
Cracked or lost the original engine coolant reservoir cap? Replace it seamlessly and effectively with this precisely engineered, direct replacement cap.

Product Features:
  • Direct replacement – this engine coolant reservoir cap directly replaces a cracked or lost original cap
  • Application specific – made to match dimensions of reservoir cap on only certain vehicle years, makes and models
  • Seamless fit – reverse-engineered from the original equipment to fit perfectly
  • Excellent value – a quick, easy replacement that’s less expensive than going back to the dealership
See More

Dorman – Help – Engine Coolant Reservoir Cap: Twist, Plastic, 1 Pack (Part No.54218CD)

Engine Coolant Reservoir Cap: Twist, Plastic, 1 Pack

from

$17.99
Cracked or lost the original engine coolant reservoir cap? Replace it seamlessly and effectively with this precisely engineered, direct replacement cap.

Product Features:
  • Direct replacement – this engine coolant reservoir cap directly replaces a cracked or lost original cap
  • Application specific – made to match dimensions of reservoir cap on only certain vehicle years, makes and models
  • Seamless fit – reverse-engineered from the original equipment to fit perfectly
  • Excellent value – a quick, easy replacement that’s less expensive than going back to the dealership
See More

Top-Rated Engine Cooling Part Brands For Your 2021 GMC Sierra 3500 HD

When it comes to finding the perfect Engine Cooling Part for your 2021 GMC Sierra 3500 HD, Advance Auto Parts has you covered with a wide selection of high-quality OEM and aftermarket options from 6 trusted brands. We carry the most popular Engine Cooling Part brands including Carquest Premium, Motorad, and Dorman, and more, all known for their exceptional customer ratings (average brand rating of 4.4 stars) and competitive prices, as low as $17.99. Purchasing a Engine Cooling Part from us here at Advance Auto Parts is a smart move for both you and your 2021 GMC Sierra 3500 HD, providing peace of mind with parts that meet or exceed OEM standards.

Popular Carquest Premium 2021 GMC Sierra 3500 HD Engine Cooling Parts

If you’re looking for a top-quality Engine Cooling Part for your 2021 GMC Sierra 3500 HD, Advance Auto Parts has exactly what you need with our selection of Carquest Premium Engine Cooling Parts. We have 3 Carquest Premium Engine Cooling Parts in stock for this fitment, all known for their durability and precision fit. With prices starting at just $21.99 and an average cost of $36.32, you’ll find the perfect Engine Cooling Part for your needs and budget. Carquest Premium Engine Cooling Parts for the 2021 GMC Sierra 3500 HD come highly rated, with over 20 customer reviews and an impressive average rating of 4.4 stars. Choosing a Carquest Premium Engine Cooling Part from Advance Auto Parts is a smart move to ensure quality and value for your vehicle.
Radiator Cap: 20 PSI
from $21.99
(6)
Radiator Cap: 20 PSI
“Easy to deal with and great products”
Standard Thermostat: With Seal, 180 Degrees
from $42.99
(7)
Standard Thermostat: With Seal, 180 Degrees
“Put in top block”
Standard Thermostat: With Seal, 185 Degrees
from $43.99
(7)
Standard Thermostat: With Seal, 185 Degrees
“Online purchase is great”

Top-Quality Motorad 2021 GMC Sierra 3500 HD Engine Cooling Parts

For those in search of a high-quality Engine Cooling Part for their 2021 GMC Sierra 3500 HD, Advance Auto Parts offers a great selection of Motorad Engine Cooling Parts. With 1 Motorad Engine Cooling Parts in stock, you can trust you’re getting top-tier parts designed for durability and a perfect fit. Prices for these Engine Cooling Parts start at just $46.99, giving you a range of options to suit your budget. Backed by over 3 customer ratings and an average rating of 4.3 stars, Motorad Engine Cooling Parts provide both reliability and excellent performance. Choosing a Motorad Engine Cooling Part from Advance Auto Parts is a smart investment in your vehicle’s performance and longevity.
Standard Thermostat: With Seals, 180, 185 Degrees
from $46.99
(3)
Standard Thermostat: With Seals, 180, 185 Degrees
“Product was correct! Repair went well”

FAQs for 2021 GMC Sierra 3500 HD Engine Cooling Parts

What are the best-selling Engine Cooling Parts for 2021 GMC Sierra 3500 HDs?

Out of 22 Engine Cooling Parts that fit 2021 GMC Sierra 3500 HDs, the following parts are the top sellers:

What’s the price range for 2021 GMC Sierra 3500 HD Engine Cooling Parts?

The prices of Engine Cooling Parts for the 2021 GMC Sierra 3500 HD range from $8.99 up to $809.99 for the most premium parts.

What is the average price of an Engine Cooling Part for a 2021 GMC Sierra 3500 HD?

The average price for Engine Cooling Parts for the 2021 GMC Sierra 3500 HD is $59.58. Keep in mind the variety of part types within our Engine Cooling Part category, where you are likely to find a wide range of prices across a variety of parts and components.

Does Advance Auto Parts sell Engine Cooling Parts for other GMC Sierra 3500 HD model years?

Yes, we carry Engine Cooling Parts for 18 model years of GMC Sierra 3500 HDs between 2007 and 2026. The following model years are the most popular for Engine Cooling Part purchases: 2023, 2022, 2020, 2019, 2018, 2017, 2016, 2015, and 2014.

What are the cheapest Engine Cooling Parts for my 2021 GMC Sierra 3500 HD?

The cheapest 2021 GMC Sierra 3500 HD Engine Cooling Parts we carry are:

Does Advance Auto Parts sell Engine Cooling Parts for any other 2021 GMC models?

What are the top-rated Engine Cooling Parts that fit the 2021 GMC Sierra 3500 HD?

Based on 374 reviews by customers, our 2021 GMC Sierra 3500 HD Engine Cooling Parts have an average customer rating of 5 stars. These are the highest-rated categories of Engine Cooling Parts for the 2021 GMC Sierra 3500 HD and their top-rated products:

What types of Engine Cooling Parts do you sell for my 2021 GMC Sierra 3500 HD?

As of 11/2/25, these are some of the most in-demand types of Engine Cooling Parts for a 2021 GMC Sierra 3500 HD:

Can I get help with 2021 GMC Sierra 3500 HD Engine Cooling Part orders?

Contact our customer support team by chat or phone, through the help desk page, where you can find instant answers about GMC Engine Cooling Parts and more.

What is your return policy for GMC Sierra 3500 HD Engine Cooling Parts?

Advance Auto Parts keeps returns simple. For new GMC Sierra 3500 HD Engine Cooling Parts and accessories, your online orders can be returned, in their original condition, within 45 days. For requirements, see the returns page.