2021 Chevrolet Silverado 2500 HD Cooling and Climate Controls

Essential Cooling and Climate Controls for 2021 Chevrolet Silverado 2500 HDs

Dorman – Water Pump Outlet Pipe (Part No.626-661)

Water Pump Outlet Pipe

from

$82.99
This engine coolant pipe is designed to match the fit and function of the original pipe on specified vehicles. It is engineered to help ensure leak-free coolant transfer when an original pipe has failed from heat or corrosion..

Product Features:
  • Direct replacement – this engine coolant pipe is designed to match the fit and function of the original pipe on specified vehicles.
  • Ideal solution – engineered to help ensure leak-free coolant transfer when an original pipe has failed from heat or corrosion
  • Durable construction – designed and manufactured to strict specifications for reliable performance
  • Trustworthy quality – backed by a team of product experts in the United States and more than a century of automotive experience
See More

Carquest Premium – A/C New, with Clutch, with 10SE18 Compressor (Part No.T198353)

A/C New, with Clutch, with 10SE18 Compressor

from

$294.99
Carquest New Compressors are designed, manufactured and tested to meet or exceed strict original equipment specifications for superior quality and performance. Each new compressor is tested to provide durable life to the vehicle’s air conditioning system. All new compressor components are assembled using state of the art equipment and techniques to ensure smooth operation. Each part is equipped with a clutch and connector that matches the original equipment part and provides an exact replacement to your vehicle’s part. All compressors are supplied with the necessary gaskets and o-rings for installation.

Product Features:
  • Each new compressor design undergoes rigorous life cycle testing at high RPMs and pressures to ensure that they can withstand years in the harshest conditions.
  • New compressors are designed with utmost precision using 3D coordinate measuring machines to ensure a perfect fit.
  • The production process contains automated controls at every stage that alerts and halts production in case of an error, assuring that the finished product will always be flawless.
  • All new compressors must pass a helium leak test and pump up function test prior to packaging.
  • O-Rings and gaskets necessary for installation are included.
See More

Permatex – Water Pump & Thermostat RTV Silicone Gasket Maker, 0.5 OZ (Part No.22071)

Water Pump & Thermostat RTV Silicone Gasket Maker, 0.5 OZ

from

$6.99
Permatex Water Pump & Thermostat RTV Silicone Gasket Maker is a noncorrosive, sensor-safe RTV silicone gasket material formulated for water pumps and thermostat housings. Permatex Water Pump & Thermostat has the highest water-glycol resistance available in an RTV silicone.

Product Features:
  • Sensor-safe, noncorrosive RTV silicone gasket material
  • Formulated specifically for water pumps and thermostat housings
  • Highest water-glycol resistance available in RTV silicone
  • Superior adhesion and flexibility
  • Can be used as a gasket maker or dressing
See More

ACDelco – 12587397 GM Original Equipment Engine Coolant Water Inlet Seal (Part No.G4030310258ACD)

12587397 GM Original Equipment Engine Coolant Water Inlet Seal

from

$10.84
An ACDelco GM Original Equipment Engine Coolant Water Inlet Seal is a GM-recommended replacement for your vehicle’s original component. It seals and helps prevent coolant from leaking out of cooling system components. This original equipment engine coolant water inlet seal has been manufactured to fit your specific GM vehicle, providing the same performance, durability, and service life you expect from General Motors.

Product Features:
  • Seals and helps prevent coolant from leaking out of cooling system components to maintain the proper engine temperature
  • GM-recommended replacement part for your GM vehicle’s original factory component
  • Offering the quality, reliability, and durability of GM OE
  • Manufactured to GM OE specification for fit, form, and function
See More

GM Genuine Parts – Air Conditioning System Valve Core (Part No.15-1119)

Air Conditioning System Valve Core

from

$10.99
GM Genuine Parts A/C System Valve Cores are designed, engineered, and tested to rigorous standards, and are backed by General Motors. These A/C system valve cores are components of the A/C service valve through which your vehicle’s refrigerant can be accessed and serviced. The valve core is a spring-loaded poppet valve that is opened when the service technician connects the A/C service machine hose couplers. GM Genuine Parts are the true OE parts installed during the production of or validated by General Motors for GM vehicles. Some GM Genuine Parts may have formerly appeared as ACDelco GM Original Equipment (OE).

Product Features:
  • Repair leaking A/C system, restore A/C function
  • Helps restore A/C Function
  • Some GM Genuine Parts may have formerly appeared as ACDelco GM Original Equipment (OE)
  • GM Engineers design and validate OE parts specifically for your Chevrolet, Buick, GMC, or Cadillac vehicle
  • Original equipment parts are designed to work with your GM vehicle safety systems — aftermarket replacement parts may not meet the same OE safety regulations, depending on the part type
  • GM regularly updates production and service part designs to integrate new materials and technologies
See More

Carquest Premium – Blower Motor: With Wheel (Part No.76505)

Blower Motor: With Wheel

from

$129.99
Carquest Premium Blower Motors are engineered and tested to provide years of trouble free operation. Backed by over 50 years of mobile A/C experience, fix it once and fix it right with Carquest Premium Blower Motors. Meets or exceeds OE design. Magnetic size and properties compare or exceed OEM. Windings meet or exceed OEM Specifications. Motor RPM equivalent to or exceeds OEM motor.

Product Features:
  • Meets or exceeds OE design and performance
  • Magnetic size and properties compare or exceed OEM
  • Windings meet or exceed OEM specifications
  • Motor RPM equivalent to or exceeds OEM motor
  • Functionally Equivalent to OE Design
  • Magnetic size and properties compare or exceed OEM
  • Hermetically Sealed & Thermally Protected Electronics
See More

ACDelco – A/C Service Valve (Part No.R1129947779ACD)

A/C Service Valve

from

$13.13
A/C Service Valve

Dorman – Clutch Fan Blade: Plastic, Cost Effective And Reliable (Part No.621-106)

Clutch Fan Blade: Plastic, Cost Effective And Reliable

from

$116.99
Replace your damaged cooling fan blade with this direct replacement. This vehicle-specific application is engineered for a perfect fit and is made from quality materials to ensure durability and restore proper cooling system operation.

Product Features:
  • Direct replacement – this engine cooling fan blade fits and functions like the original equipment fan blade.
  • Quality construction – manufactured from premium materials for a long service life.
  • Excellent value – original equipment quality at a lower price
  • Quality tested – has undergone testing to ensure proper fit and performance
See More

Mahle – Water Pump Gasket (Part No.G3040310278MAH)

Water Pump Gasket

from

$6.65
Water Pump Gasket

ACDelco – GM Original Equipment Engine Cooling Fan Clutch (Part No.G5010206278ACD)

GM Original Equipment Engine Cooling Fan Clutch

from

$683.82
ACDelco GM Original Equipment Engine Cooling Fan Clutches control the speed of the radiator fan based on the temperature of the air after it passes through the radiator fins. This original equipment engine cooling fan clutch is a GM-recommended replacement for your vehicle’s original components and has been manufactured to fit your specific GM vehicle, providing the same performance, durability, and service life you expect from General Motors.

Product Features:
  • Quiets noisy cooling fans with stuck fan clutches, restores fuel economy
  • GM-recommended replacement part for your GM vehicle’s original factory component
  • Offering the quality, reliability, and durability of GM OE
  • Manufactured to GM OE specification for fit, form, and function
See More

GM Genuine Parts – Water Inlet Seal (Part No.12587397)

Water Inlet Seal

from

$8.99
GM Genuine Parts Engine Coolant Thermostat Seals are designed, engineered, and tested to rigorous standards, and are backed by General Motors. These seals help close and prevent coolant from leaking out of your vehicle’s cooling system components. GM Genuine Parts are the true OE parts installed during the production of or validated by General Motors for GM vehicles. Some GM Genuine Parts may have formerly appeared as ACDelco GM Original Equipment (OE).

Product Features:
  • Helps close and prevent coolant from leaking out of your vehicle’s cooling system components to maintain the proper engine temperature
  • Some GM Genuine Parts may have formerly appeared as ACDelco GM Original Equipment (OE)
  • GM Genuine Parts are designed, engineered and tested to rigorous standards, and are backed by General Motors
  • GM Engineers design and validate OE parts specifically for your Chevrolet, Buick, GMC, or Cadillac vehicle
  • GM regularly updates production and service part designs to integrate new materials and technologies
See More

Autopart International Inc – Expansion Tank Cap (Part No.G10402009531API)

Expansion Tank Cap

from

$12.81
Expansion Tank Cap

Carquest Premium – Coolant Housing/Water Outlet (Part No.85945)

Coolant Housing/Water Outlet

from

$20.99
We are proud to offer this CARQUEST product line: CARQUEST Water Outlets. Our products are engineered and tested to provide years of trouble free operation and designed to be hassle free OE replacement part that meets and/or exceeds OE standards. Backed by over 50 years of mobile temperature control experience, fix it once and fix it right with CARQUST Water Outlets and Thermostat Housings.

Product Features:
  • Meets and/or exceeds OEM standard
  • Includes quality gasket or O-ring to ensure proper seal (where applicable)
  • 100% leak tested
  • Direct-fit replacement for ease of installation
See More

ACDelco – GM Original Equipment Oil Cooler Seal (Part No.A6310320812ACD)

GM Original Equipment Oil Cooler Seal

from

$45.26
The ACDelco GM Original Equipment Engine Oil Cooler Seal is a GM-recommended replacement component that provides the same performance, durability, and service life as your factory original equipment.

Product Features:
  • GM-recommended replacement part for your GM vehicle’s original factory component
  • Offering the quality, reliability, and durability of GM OE
  • Manufactured to GM OE specification for fit, form, and function
See More

Dorman – Help – Engine Coolant Reservoir Cap: Twist, Plastic, 1 Pack (Part No.54218)

Engine Coolant Reservoir Cap: Twist, Plastic, 1 Pack

from

$13.99
Cracked or lost the original engine coolant reservoir cap? Replace it seamlessly and effectively with this precisely engineered, direct replacement cap.

Product Features:
  • Direct replacement – this engine coolant reservoir cap directly replaces a cracked or lost original cap.
  • Application specific – made to match dimensions of reservoir cap on only certain vehicle years, makes and models
  • Seamless fit – reverse-engineered from the original equipment to fit perfectly
  • Excellent value – a quick, easy replacement that’s less expensive than going back to the dealership
See More

Carquest Premium – Radiator Cap: 20 PSI (Part No.10271)

Radiator Cap: 20 PSI

from

$19.79
Crafted to meet the exact specifications set by Original Equipment Manufacturers (OEM), these products are engineered for effortless installation and removal. Constructed from premium-grade components, incorporating proper relief and vacuum valves, they ensure optimal performance even in the most demanding automotive cooling systems. Rigorously quality-tested, these components provide exceptional, out-of-the-box performance and superior durability to meet or exceed the highest standards of today’s vehicles.

Product Features:
  • Maintains proper cooling system pressure
  • Easy installation and removal
  • 100% tested to ensure proper pressure and longevity
  • Meets all OEM specifications
See More

Carquest Premium – Standard Thermostat: With Seal, 195 Degrees (Part No.13899)

Standard Thermostat: With Seal, 195 Degrees

from

$7.29
Carquest Premium Thermostats are manufactured with OEM quality materials and safety standards by an OE Supplier. This thermostat will meet and exceed the expectations of the OE thermostat to insure the best product for your cooling system. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant. Offset design, air relief valve, and OEM style seals included where applicable.

Product Features:
  • High grade stainless steel and copper construction
  • Meets or exceeds OEM standards
  • Consistent and precise response to cooling system needs
  • Original equipment design for worry-free direct fit replacement
  • 100% tested and calibrated
See More

Carquest Premium – Standard Thermostat: With Seal, 187 Degrees (Part No.15158)

Standard Thermostat: With Seal, 187 Degrees

from

$38.99
Carquest Premium Thermostats are manufactured with OEM quality materials and safety standards by an OE Supplier. This thermostat will meet and exceed the expectations of the OE thermostat to insure the best product for your cooling system. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant. Offset design, air relief valve, and OEM style seals included where applicable.

Product Features:
  • High grade stainless steel and copper construction
  • Meets or exceeds OEM standards
  • Consistent and precise response to cooling system needs
  • Original equipment design for worry-free direct fit replacement
  • 100% tested and calibrated
See More

Carquest Premium – Coolant Temperature Sensor (Part No.WTC1002)

Coolant Temperature Sensor

from

$20.99
Approved materials for increased durability in even the most extreme temperatures. All MotoRad Coolant Temperature Sensors are designed to meet or exceed OEM specifications at our ISO TS16949 manufacturing facilities.

Product Features:
  • 100% factory resistance calibrated to ensure precision tolerances, resulting in extremely accurate temperature for optimal performance
  • Thread Sealant and/or O-ring pre-installed on applicable sensors to ensure leak free performance
  • Brass sensor housing precision machined to meet or exceed OE thermal conductivity
  • OE precision matched thermistor position for correct output parameters
  • Extensive product testing includes salt spray, high/low temperature impact, thermal vibration, durability, static electricity, and micro tension, among other tests, to ensure all sensors meet or exceed OEM specifications.
See More

Carquest Premium – Coolant Temperature Sensor (Part No.WTC1261)

Coolant Temperature Sensor

from

$28.99
Approved materials for increased durability in even the most extreme temperatures. All MotoRad Coolant Temperature Sensors are designed to meet or exceed OEM specifications at our ISO TS16949 manufacturing facilities.

Product Features:
  • 100% factory resistance calibrated to ensure precision tolerances, resulting in extremely accurate temperature for optimal performance
  • Thread Sealant and/or O-ring pre-installed on applicable sensors to ensure leak free performance
  • Brass sensor housing precision machined to meet or exceed OE thermal conductivity
  • OE precision matched thermistor position for correct output parameters
  • Extensive product testing includes salt spray, high/low temperature impact, thermal vibration, durability, static electricity, and micro tension, among other tests, to ensure all sensors meet or exceed OEM specifications.
See More

GM Genuine Parts – Multi-Purpose Relay (Part No.15016745)

Multi-Purpose Relay

from

$49.49
GM Genuine Parts Wiring Relays are designed, engineered, and tested to rigorous standards, and are backed by General Motors. These relays help connect or disconnect power to a vehicle accessory when it receives a low voltage signal from a switch. GM Genuine Parts are the true OE parts installed during the production of or validated by General Motors for GM vehicles. Some GM Genuine Parts may have formerly appeared as ACDelco GM Original Equipment (OE).

Product Features:
  • Helps connect or disconnect power to vehicle accessories
  • Some GM Genuine Parts may have formerly appeared as ACDelco GM Original Equipment (OE)
  • GM Genuine Parts are designed, engineered and tested to rigorous standards, and are backed by General Motors
  • GM Engineers design and validate OE parts specifically for your Chevrolet, Buick, GMC, or Cadillac vehicle
  • GM regularly updates production and service part designs to integrate new materials and technologies
See More

ACDelco – Relay (Part No.P2020765633ACD)

Relay

from

$16.19
Relay

Dorman – Coolant Housing/Water Outlet: With Water Outlet, 90 Degree Neck Angle (Part No.902-2127)

Coolant Housing/Water Outlet: With Water Outlet, 90 Degree Neck Angle

from

$111.99
This replacement engine coolant thermostat housing is engineered to match the fit and durability of the stock thermostat housing on specified vehicles. It is designed to withstand extreme temperature changes to extend service life.

Product Features:
  • Ideal replacement – this engine coolant thermostat housing directly replaces the original housing on specified vehicle years, makes and models.
  • Durable construction – this part is specifically designed to withstand extreme temperature changes and resist cracking and leaking.
  • Cost-effective and reliable – offers original manufacturer quality at lower cost than getting replacement at dealer
  • Industry-leading design – professionally engineered by the aftermarket leader in replacement thermostat housings
See More

Motorad – Coolant Housing/Water Outlet: (Part No.CH6007)

Coolant Housing/Water Outlet:

from

$78.99
Manufactured with OEM quality materials and safety standards by an OE Supplier. This housing will meet and exceed the expectations of the OE thermostat to insure the best product for your cooling system. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. The construction of this housing is improved over the OE design to fix and update any issues that the OE design may have had.

Product Features:
  • Easy, one step fit and installation
  • No special tools required
  • Meets or exceeds all OEM standards
See More

Delphi – A/C Compressor (Part No.CS20039)

A/C Compressor

from

$274.99
100 years of OE experience, supplier to the world’s top automakers, OE Heritage and knowledge built into every aftermarket part.

Product Features:
  • All Delphi compressors are an exact fit
  • Sealing washers are included (where applicable) with all Delphi compressors and no extra parts to purchase
  • All Delphi compressors are 100% leak tested
  • Delphi compressors are constructed with high-quality corrosion resistant aluminum alloy not often found in aftermarket products
  • Low torque demand results in better engine performance and increased fuel economy
  • All Delphi compressors meet or exceed OE specifications
See More

GM Genuine Parts – Air Conditioning Compressor and Clutch Assembly (Part No.15-22319)

Air Conditioning Compressor and Clutch Assembly

from

$361.99
GM Genuine Parts A/C Compressors are designed, engineered, and tested to rigorous standards, and are backed by General Motors. These compressors pump refrigerant through the system. The compressor is typically engine driven via the accessory belt, and a clutch on the compressor is used to engage and disengage the compressor. Hybrid vehicles are typically equipped with an electric motor driven compressor. The compressor is lubricated by refrigerant oil. GM Genuine Parts are the true OE parts installed during the production of or validated by General Motors for GM vehicles. Some GM Genuine Parts may have formerly appeared as ACDelco GM Original Equipment (OE).

Product Features:
  • Visual and leak-tested to help ensure the component’s quality and durability
  • The oil separator is part of the compressor and removes oil from the refrigerant to help keep system efficiency
  • GM meets an aggressive engineering requirement for compressor clutch durability and corrosion resistance. Together, these help ensure long-term quality and durability
  • Some GM Genuine Parts may have formerly appeared as ACDelco GM Original Equipment (OE)
  • GM Genuine Parts are designed, engineered and tested to rigorous standards, and are backed by General Motors
  • GM Engineers design and validate OE parts specifically for your Chevrolet, Buick, GMC, or Cadillac vehicle
  • GM regularly updates production and service part designs to integrate new materials and technologies
See More

Upgrade your 2021 Chevrolet Silverado 2500 HD with Top-Quality Cooling and Climate Controls

When it comes to maintaining or upgrading your 2021 Chevrolet Silverado 2500 HD, nothing is more important than using high-quality OEM or aftermarket parts that you can trust. Whether you’re repairing damage to your Chevrolet or enhancing its overall performance, Cooling and Climate Controls are key to keeping your Silverado 2500 HD functioning at its best. At Advance Auto Parts, we offer a wide selection of 32 Cooling and Climate Controls for the 2021 Chevrolet Silverado 2500 HD, designed to meet your needs without breaking the bank. From Engine Cooling Part replacements to Blower Motor and Related Products upgrades, we’ve got you covered with parts that fit your vehicle perfectly and ensure long-lasting performance.

Affordable Prices and Wide Selection

Shopping for Cooling and Climate Controls for any vehicle can be a hassle, especially if you’re on a budget. But with Advance Auto Parts, you can find high-quality Cooling and Climate Controls for your 2021 Chevrolet Silverado 2500 HD at great prices. Our Cooling and Climate Controls inventory for this model ranges from just $4.85 to $576.99, with an average price of $60.67. Our 32 Cooling and Climate Controls in stock come from 9 trusted brands, so you’re sure to find the right part for your 2021 Chevrolet Silverado 2500 HD without overspending.

Top Brands and High Customer Satisfaction

Advance Auto Parts takes pride in offering only the best brands in the automotive industry. For your 2021 Chevrolet Silverado 2500 HD, we stock popular OEM and aftermarket Cooling and Climate Controls from top names like Carquest Premium, Motorad, Dorman, and more. Carquest Premium Cooling and Climate Controls start at just $10.99 and boast an impressive 4 stars average rating from customers. Motorad and Dorman also bring quality to the table, with Cooling and Climate Controls available starting at $13.99, and at an average 4 stars rating. With 415 customer reviews and counting, our 2021 Chevrolet Silverado 2500 HD Cooling and Climate Controls have a strong track record of reliability, ensuring you can trust your purchase.

Explore Related Parts and More

While you’re here, don’t forget to check out other essential categories that go hand in hand with Cooling and Climate Control upgrades. Explore related part types like Batteries and Chargers, Oil and Lubricants and more to make sure your 2021 Chevrolet Silverado 2500 HD is always ready to roll. We’re committed to providing you with everything you need to keep your Silverado 2500 HD in top shape, all in one place. Start shopping confidently below for your 2021 Chevrolet Silverado 2500 HD!

Best-Selling Engine Cooling Parts for 2021 Chevrolet Silverado 2500 HDs

Enhance the driving experience in your Chevrolet with 24 quality Engine Cooling Part components, starting at $4.85.

Motorad – Standard Thermostat: With Seals, 180, 185 Degrees (Part No.447448)

Standard Thermostat: With Seals, 180, 185 Degrees

from

$40.99
Manufactured with OEM quality materials and safety standards by an OE Supplier. This thermostat will meet and exceed the expectations of the OE thermostat to insure the best product for your cooling system. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant. Offset design, air relief valve, and OEM style seals included where applicable.

Product Features:
  • High grade stainless steel and copper construction
  • Meets or exceeds OEM standards
  • Consistent and precise response to cooling system needs
  • Original equipment design for worry-free direct fit replacement
  • 100% tested and calibrated
See More

Carquest Premium – Radiator Cap: 20 PSI (Part No.10271)

Radiator Cap: 20 PSI

from

$19.79
Crafted to meet the exact specifications set by Original Equipment Manufacturers (OEM), these products are engineered for effortless installation and removal. Constructed from premium-grade components, incorporating proper relief and vacuum valves, they ensure optimal performance even in the most demanding automotive cooling systems. Rigorously quality-tested, these components provide exceptional, out-of-the-box performance and superior durability to meet or exceed the highest standards of today’s vehicles.

Product Features:
  • Maintains proper cooling system pressure
  • Easy installation and removal
  • 100% tested to ensure proper pressure and longevity
  • Meets all OEM specifications
See More

Dorman – Help – Engine Coolant Reservoir Cap: Twist, Plastic, 1 Pack (Part No.54218)

Engine Coolant Reservoir Cap: Twist, Plastic, 1 Pack

from

$13.99
Cracked or lost the original engine coolant reservoir cap? Replace it seamlessly and effectively with this precisely engineered, direct replacement cap.

Product Features:
  • Direct replacement – this engine coolant reservoir cap directly replaces a cracked or lost original cap.
  • Application specific – made to match dimensions of reservoir cap on only certain vehicle years, makes and models
  • Seamless fit – reverse-engineered from the original equipment to fit perfectly
  • Excellent value – a quick, easy replacement that’s less expensive than going back to the dealership
See More

ACDelco – GM Original Equipment Engine Coolant Thermostat (Part No.G4000310418ACD)

GM Original Equipment Engine Coolant Thermostat

from

$81.39
An ACDelco GM Original Equipment Engine Coolant Thermostat is a temperature controlled valve located in the engine coolant outlet to, or the inlet from, the radiator, and is a GM-recommended replacement for your vehicle’s original component. It controls the flow of coolant through the radiator to enable the engine to reach and maintain its normal operating temperature. This original equipment engine coolant thermostat has been manufactured to fit your specific GM vehicle, providing the same performance, durability, and service life you expect from General Motors.

Product Features:
  • Control the flow of coolant through the radiator to enable the engine to reach and maintain its normal operating temperature
  • GM-recommended replacement part for your GM vehicle’s original factory component
  • Offering the quality, reliability, and durability of GM OE
  • Manufactured to GM OE specification for fit, form, and function
See More

Carquest Premium – Standard Thermostat: With Seal, 185 Degrees (Part No.14728)

Standard Thermostat: With Seal, 185 Degrees

from

$43.99
Carquest Premium Thermostats are manufactured with OEM quality materials and safety standards by an OE Supplier. This thermostat will meet and exceed the expectations of the OE thermostat to insure the best product for your cooling system. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant. Offset design, air relief valve, and OEM style seals included where applicable.

Product Features:
  • High grade stainless steel and copper construction
  • Meets or exceeds OEM standards
  • Consistent and precise response to cooling system needs
  • Original equipment design for worry-free direct fit replacement
  • 100% tested and calibrated
See More

Carquest Premium – Standard Thermostat: With Seal, 180 Degrees (Part No.14738)

Standard Thermostat: With Seal, 180 Degrees

from

$42.99
Carquest Premium Thermostats are manufactured with OEM quality materials and safety standards by an OE Supplier. This thermostat will meet and exceed the expectations of the OE thermostat to insure the best product for your cooling system. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant. Offset design, air relief valve, and OEM style seals included where applicable.

Product Features:
  • High grade stainless steel and copper construction
  • Meets or exceeds OEM standards
  • Consistent and precise response to cooling system needs
  • Original equipment design for worry-free direct fit replacement
  • 100% tested and calibrated
See More

Carquest Premium – Standard Thermostat: With Seal, 187 Degrees (Part No.15158)

Standard Thermostat: With Seal, 187 Degrees

from

$38.99
Carquest Premium Thermostats are manufactured with OEM quality materials and safety standards by an OE Supplier. This thermostat will meet and exceed the expectations of the OE thermostat to insure the best product for your cooling system. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant. Offset design, air relief valve, and OEM style seals included where applicable.

Product Features:
  • High grade stainless steel and copper construction
  • Meets or exceeds OEM standards
  • Consistent and precise response to cooling system needs
  • Original equipment design for worry-free direct fit replacement
  • 100% tested and calibrated
See More

Dorman – Help – Engine Coolant Reservoir Cap: Twist, Plastic, 1 Pack (Part No.54218CD)

Engine Coolant Reservoir Cap: Twist, Plastic, 1 Pack

from

$16.99
Cracked or lost the original engine coolant reservoir cap? Replace it seamlessly and effectively with this precisely engineered, direct replacement cap.

Product Features:
  • Direct replacement – this engine coolant reservoir cap directly replaces a cracked or lost original cap.
  • Application specific – made to match dimensions of reservoir cap on only certain vehicle years, makes and models
  • Seamless fit – reverse-engineered from the original equipment to fit perfectly
  • Excellent value – a quick, easy replacement that’s less expensive than going back to the dealership
See More

ACDelco – GM Original Equipment Expansion Tank Cap (Part No.G1040465619ACD)

GM Original Equipment Expansion Tank Cap

from

$21.02
An ACDelco GM Original Equipment Expansion Tank Cap is a spring loaded cap that seals the radiator filler neck or surge tank, and is a GM-recommended replacement for your vehicle’s original component. It maintains pressure on the cooling system while the engine is operating, which raises the boiling point of the engine coolant. It also replenishes the system with coolant from the expansion tank (if equipped) when the engine cools off. This original equipment radiator cap has been manufactured to fit your specific GM vehicle, providing the same performance, durability, and service life you expect from General Motors. Get the GM quality you know and trust with ACDelco GM Original Equipment Thermostats and Caps. Stay with the brand of parts your General Motors vehicle came with and get peace of mind that the fit, form, and function is up to the high standards and specifications of General Motors. ACDelco GM Original Equipment Thermostats and Caps are engineered for virtually every model of GM car, light duty truck, and sport utility vehicle.

Product Features:
  • Seal and maintain pressure on the cooling system for vehicle safety
  • Raise the boiling point of the engine coolant to maintain efficiency
  • Fit most models of GM vehicles for expanded coverage
  • GM-recommended replacement part for your GM vehicle’s original factory component
  • Offering the quality, reliability, and durability of GM OE
  • Manufactured to GM OE specification for fit, form, and function
See More

Carquest Premium – Coolant Housing/Water Outlet (Part No.85945)

Coolant Housing/Water Outlet

from

$20.99
We are proud to offer this CARQUEST product line: CARQUEST Water Outlets. Our products are engineered and tested to provide years of trouble free operation and designed to be hassle free OE replacement part that meets and/or exceeds OE standards. Backed by over 50 years of mobile temperature control experience, fix it once and fix it right with CARQUST Water Outlets and Thermostat Housings.

Product Features:
  • Meets and/or exceeds OEM standard
  • Includes quality gasket or O-ring to ensure proper seal (where applicable)
  • 100% leak tested
  • Direct-fit replacement for ease of installation
See More

Felpro – Engine Water Pump Gasket (Part No.36110)

Engine Water Pump Gasket

from

$7.49
Fel-Pro gaskets offer 100% vehicle sealing with application-specific materials to give you sealing solutions with the performance and durability professionals trust

Product Features:
  • Meets or exceeds all original equipment specifications
  • Application specific design
  • Manufactured for the sealing repair environment
  • Validated for fit, form, and function
  • Quality that you can trust
See More

Felpro – Engine Water Pump Gasket (Part No.36109)

Engine Water Pump Gasket

from

$19.29
Fel-Pro gaskets offer 100% vehicle sealing with application-specific materials to give you sealing solutions with the performance and durability professionals trust

Product Features:
  • Meets or exceeds all original equipment specifications
  • Application specific design
  • Manufactured for the sealing repair environment
  • Validated for fit, form, and function
  • Quality that you can trust
See More

Mahle – Engine Coolant Thermostat O-Ring (Part No.G4030310258MAH)

Engine Coolant Thermostat O-Ring

from

$7.41
The Mahle Engine Coolant Thermostat O-Ring is a high quality Original Equipment replacement that is manufactured to meet or exceed OE specifications for fit, form, and function.

Product Features:
  • Seals the thermostat housing and helps prevent coolant from leaking from the engine for proper engine temperature
  • Premium Original Equipment replacement
  • Provides performance and dependability
  • Manufactured to meet OE specifications
See More

Dorman – Clutch Fan Blade: Plastic, Cost Effective And Reliable (Part No.621-111)

Clutch Fan Blade: Plastic, Cost Effective And Reliable

from

$112.99
Replace your damaged cooling fan blade with this direct replacement. This vehicle-specific application is engineered for a perfect fit and is made from quality materials to ensure durability and restore proper cooling system operation.

Product Features:
  • Direct replacement – this engine cooling fan blade fits and functions like the original equipment fan blade.
  • Quality construction – manufactured from premium materials for a long service life.
  • Excellent value – original equipment quality at a lower price
  • Quality tested – has undergone testing to ensure proper fit and performance
See More

ACDelco – GM Original Equipment Oil Cooler Seal (Part No.A6310320812ACD)

GM Original Equipment Oil Cooler Seal

from

$45.26
The ACDelco GM Original Equipment Engine Oil Cooler Seal is a GM-recommended replacement component that provides the same performance, durability, and service life as your factory original equipment.

Product Features:
  • GM-recommended replacement part for your GM vehicle’s original factory component
  • Offering the quality, reliability, and durability of GM OE
  • Manufactured to GM OE specification for fit, form, and function
See More

Carquest Premium – Reverse Rotation Severe Duty Thermal Fan Clutch (Part No.46145)

Reverse Rotation Severe Duty Thermal Fan Clutch

from

$128.99
Product Features:
  • Designed, tested, and built by application
  • OE performance, fit, and appearance
  • Precision machined
  • Out of box installation
See More

Dorman – Water Pump Outlet Pipe (Part No.626-661)

Water Pump Outlet Pipe

from

$82.99
This engine coolant pipe is designed to match the fit and function of the original pipe on specified vehicles. It is engineered to help ensure leak-free coolant transfer when an original pipe has failed from heat or corrosion..

Product Features:
  • Direct replacement – this engine coolant pipe is designed to match the fit and function of the original pipe on specified vehicles.
  • Ideal solution – engineered to help ensure leak-free coolant transfer when an original pipe has failed from heat or corrosion
  • Durable construction – designed and manufactured to strict specifications for reliable performance
  • Trustworthy quality – backed by a team of product experts in the United States and more than a century of automotive experience
See More

ACDelco – 15-10595 GM Original Equipment Engine Coolant Water Outlet (Part No.G4010349243ACD)

15-10595 GM Original Equipment Engine Coolant Water Outlet

from

$18.46
ACDelco GM Original Equipment Engine Coolant Water Outlets are housings that connect the radiator hoses to the engine, typically housing the engine coolant thermostat. For certain applications, the water outlet contains threaded holes or ports for sensors and switches. These original equipment engine coolant water outlets are GM-recommended replacements for your vehicle’s original components and have been manufactured to fit your specific GM vehicle, providing the same performance, durability, and service life you expect from General Motors.

Product Features:
  • GM-recommended replacement part for your GM vehicle’s original factory component
  • Offering the quality, reliability, and durability of GM OE
  • Manufactured to GM OE specification for fit, form, and function
See More

Worldpac – THERMOSTAT HOUSING (Part No.G40101697790DOR)

THERMOSTAT HOUSING

from

$16.28
THERMOSTAT HOUSING

Autopart International Inc – Expansion Tank Cap (Part No.G10402009531API)

Expansion Tank Cap

from

$12.81
Expansion Tank Cap

Carquest Premium – Coolant Temperature Sensor (Part No.WTC1276)

Coolant Temperature Sensor

from

$10.99
Approved materials for increased durability in even the most extreme temperatures. All MotoRad Coolant Temperature Sensors are designed to meet or exceed OEM specifications at our ISO TS16949 manufacturing facilities.

Product Features:
  • 100% factory resistance calibrated to ensure precision tolerances, resulting in extremely accurate temperature for optimal performance
  • Thread Sealant and/or O-ring pre-installed on applicable sensors to ensure leak free performance
  • Brass sensor housing precision machined to meet or exceed OE thermal conductivity
  • OE precision matched thermistor position for correct output parameters
  • Extensive product testing includes salt spray, high/low temperature impact, thermal vibration, durability, static electricity, and micro tension, among other tests, to ensure all sensors meet or exceed OEM specifications.
See More

ACDelco – 12587397 GM Original Equipment Engine Coolant Water Inlet Seal (Part No.G4030310258ACD)

12587397 GM Original Equipment Engine Coolant Water Inlet Seal

from

$10.84
An ACDelco GM Original Equipment Engine Coolant Water Inlet Seal is a GM-recommended replacement for your vehicle’s original component. It seals and helps prevent coolant from leaking out of cooling system components. This original equipment engine coolant water inlet seal has been manufactured to fit your specific GM vehicle, providing the same performance, durability, and service life you expect from General Motors.

Product Features:
  • Seals and helps prevent coolant from leaking out of cooling system components to maintain the proper engine temperature
  • GM-recommended replacement part for your GM vehicle’s original factory component
  • Offering the quality, reliability, and durability of GM OE
  • Manufactured to GM OE specification for fit, form, and function
See More

GM Genuine Parts – Water Inlet Seal (Part No.12587397)

Water Inlet Seal

from

$8.99
GM Genuine Parts Engine Coolant Thermostat Seals are designed, engineered, and tested to rigorous standards, and are backed by General Motors. These seals help close and prevent coolant from leaking out of your vehicle’s cooling system components. GM Genuine Parts are the true OE parts installed during the production of or validated by General Motors for GM vehicles. Some GM Genuine Parts may have formerly appeared as ACDelco GM Original Equipment (OE).

Product Features:
  • Helps close and prevent coolant from leaking out of your vehicle’s cooling system components to maintain the proper engine temperature
  • Some GM Genuine Parts may have formerly appeared as ACDelco GM Original Equipment (OE)
  • GM Genuine Parts are designed, engineered and tested to rigorous standards, and are backed by General Motors
  • GM Engineers design and validate OE parts specifically for your Chevrolet, Buick, GMC, or Cadillac vehicle
  • GM regularly updates production and service part designs to integrate new materials and technologies
See More

Mahle – Thermostat Housing G (Part No.G40202287153MAH)

Thermostat Housing G

from

$4.85
Thermostat Housing G

Most Popular 2021 Chevrolet Silverado 2500 HD Blower Motor and Related Products

Customize your Chevrolet with 1 Blower Motor and Related Products products like Blower Motors, all priced under $266.99.

Carquest Premium – Blower Motor: With Wheel (Part No.75158)

Blower Motor: With Wheel

from

$266.99
Carquest Premium Blower Motors are engineered and tested to provide years of trouble free operation. Backed by over 50 years of mobile A/C experience, fix it once and fix it right with Carquest Premium Blower Motors. Meets or exceeds OE design. Magnetic size and properties compare or exceed OEM. Windings meet or exceed OEM Specifications. Motor RPM equivalent to or exceeds OEM motor.

Product Features:
  • Meets or exceeds OE design and performance
  • Magnetic size and properties compare or exceed OEM
  • Windings meet or exceed OEM specifications
  • Motor RPM equivalent to or exceeds OEM motor
  • Meets or exceeds OE design and performance
  • Magnetic size and properties compare or exceed OEM
  • Windings meet or exceed OEM specifications
  • Motor RPM equivalent to or exceeds OEM motor
See More

Top Picks for 2021 Chevrolet Silverado 2500 HD Air Conditioning Parts

Upgrade Chevrolet Silverado 2500 HDs with top-quality Air Conditioning Parts parts, including 7 OEM and aftermarket selections for your 2021 model.

GM Genuine Parts – Air Conditioning System Valve Core (Part No.15-1119)

Air Conditioning System Valve Core

from

$10.99
GM Genuine Parts A/C System Valve Cores are designed, engineered, and tested to rigorous standards, and are backed by General Motors. These A/C system valve cores are components of the A/C service valve through which your vehicle’s refrigerant can be accessed and serviced. The valve core is a spring-loaded poppet valve that is opened when the service technician connects the A/C service machine hose couplers. GM Genuine Parts are the true OE parts installed during the production of or validated by General Motors for GM vehicles. Some GM Genuine Parts may have formerly appeared as ACDelco GM Original Equipment (OE).

Product Features:
  • Repair leaking A/C system, restore A/C function
  • Helps restore A/C Function
  • Some GM Genuine Parts may have formerly appeared as ACDelco GM Original Equipment (OE)
  • GM Engineers design and validate OE parts specifically for your Chevrolet, Buick, GMC, or Cadillac vehicle
  • Original equipment parts are designed to work with your GM vehicle safety systems — aftermarket replacement parts may not meet the same OE safety regulations, depending on the part type
  • GM regularly updates production and service part designs to integrate new materials and technologies
See More

Carquest Premium – A/C New, with Clutch, with 7SAS17F Compressor (Part No.T168305)

A/C New, with Clutch, with 7SAS17F Compressor

from

$576.99
Carquest New Compressors are designed, manufactured and tested to meet or exceed strict original equipment specifications for superior quality and performance. Each new compressor is tested to provide durable life to the vehicle’s air conditioning system. All new compressor components are assembled using state of the art equipment and techniques to ensure smooth operation. Each part is equipped with a clutch and connector that matches the original equipment part and provides an exact replacement to your vehicle’s part. All compressors are supplied with the necessary gaskets and o-rings for installation.

Product Features:
  • Each new compressor design undergoes rigorous life cycle testing at high RPMs and pressures to ensure that they can withstand years in the harshest conditions.
  • New compressors are designed with utmost precision using 3D coordinate measuring machines to ensure a perfect fit.
  • The production process contains automated controls at every stage that alerts and halts production in case of an error, assuring that the finished product will always be flawless.
  • All new compressors must pass a helium leak test and pump up function test prior to packaging.
  • O-Rings and gaskets necessary for installation are included.
See More

Autopart International Inc – A/C Compressor (Part No.R10003199103API)

A/C Compressor

from

$363.02
A/C Compressor

Carquest Premium – New, with Clutch, with 7SAS17A Compressor (Part No.T168343)

New, with Clutch, with 7SAS17A Compressor

from

$284.99
Carquest New Compressors are designed, manufactured and tested to meet or exceed strict original equipment specifications for superior quality and performance. Each new compressor is tested to provide durable life to the vehicle’s air conditioning system. All new compressor components are assembled using state of the art equipment and techniques to ensure smooth operation. Each part is equipped with a clutch and connector that matches the original equipment part and provides an exact replacement to your vehicle’s part. All compressors are supplied with the necessary gaskets and o-rings for installation.

Product Features:
  • Each new compressor design undergoes rigorous life cycle testing at high RPMs and pressures to ensure that they can withstand years in the harshest conditions.
  • New compressors are designed with utmost precision using 3D coordinate measuring machines to ensure a perfect fit.
  • The production process contains automated controls at every stage that alerts and halts production in case of an error, assuring that the finished product will always be flawless.
  • All new compressors must pass a helium leak test and pump up function test prior to packaging.
  • O-Rings and gaskets necessary for installation are included.
See More

ACDelco – Relay (Part No.P2020765633ACD)

Relay

from

$16.19
Relay

GM Genuine Parts – Air Conditioning Line O-Ring (Part No.13579649)

Air Conditioning Line O-Ring

from

$15.99
GM Genuine Parts Rubber-Bonded Sealing Washers are designed, engineered, and tested to rigorous standards, and are backed by General Motors. GM Genuine Parts are the true OE parts installed during the production of or validated by General Motors for GM vehicles. Some GM Genuine Parts may have formerly appeared as ACDelco GM Original Equipment (OE).

Product Features:
  • Some GM Genuine Parts may have formerly appeared as ACDelco GM Original Equipment (OE)
  • GM Engineers design and validate OE parts specifically for your Chevrolet, Buick, GMC, or Cadillac vehicle
  • Original equipment parts are designed to work with your GM vehicle safety systems — aftermarket replacement parts may not meet the same OE safety regulations, depending on the part type
  • GM regularly updates production and service part designs to integrate new materials and technologies
See More

ACDelco – A/C Service Valve (Part No.R1129947779ACD)

A/C Service Valve

from

$13.13
A/C Service Valve

Top-Rated Cooling and Climate Controls Brands For Your 2021 Chevrolet Silverado 2500 HD

Shop for the best-rated brands offering Cooling and Climate Controls and other products for your 2021 Chevrolet Silverado 2500 HDs. Below you’ll find some of our best rated Cooling and Climate Controls from Carquest Premium, Motorad, and Dorman, and more. Cooling and Climate Controls from these brands that fit a 2021 Silverado 2500 HD start at just $10.99 and are rated as high as 4 stars. OEM and aftermarket Cooling and Climate Controls don’t get more top quality, durable, and affordable than from the brands below.

Popular Carquest Premium 2021 Chevrolet Silverado 2500 HD Cooling and Climate Controls

When it comes to maintaining or upgrading your 2021 Chevrolet Silverado 2500 HD, using quality Cooling and Climate Controls is essential to ensure durability and a perfect fit. Carquest Premium ticks all of those boxes. We offer a wide selection of Carquest Premium Cooling and Climate Controls, specifically designed for the 2021 Chevrolet Silverado 2500 HD. With over 10 Carquest Premium brand Cooling and Climate Controls in stock, you’re sure to find what you need. The prices for these top-notch parts start as low as $10.99, with an average price of just $143.57. Plus, with over 65 customer reviews and an average rating of 4 stars, you can trust that our Carquest Premium Cooling and Climate Controls will get the job done right. Choose Advance Auto Parts for reliability, quality, and expert-approved parts that keep your vehicle running strong.

New, with Clutch, with 7SAS17A Compressor
from
$284.99
This product is not rated

New, with Clutch, with 7SAS17A Compressor

“”

Coolant Housing/Water Outlet
from
$20.99
This product is not rated

Coolant Housing/Water Outlet

“”

A/C New, with Clutch, with 7SAS17F Compressor
from
$576.99
This product is not rated

A/C New, with Clutch, with 7SAS17F Compressor

“”

Popular Motorad 2021 Chevrolet Silverado 2500 HD Cooling and Climate Controls

Motorad auto parts is one of the highest quality Cooling and Climate Control brands in the market. Any 2021 Chevrolet Silverado 2500 HD owner should feel confident when installing genuine Motorad parts in their vehicle. To ensure the best fit and performance for your 2021 Silverado 2500 HD, Advance Auto Parts carries a full inventory of 1 Motorad Cooling and Climate Controls. Plus you will be keeping your Chevrolet in peak condition while saving money because prices on these Motorad Cooling and Climate Controls range up to $40.99, plus, with more than 3 customer reviews and an impressive 4 stars average rating, you can be confident the Fram Cooling and Climate Controls below will deliver on both quality and value.

Standard Thermostat: With Seals, 180, 185 Degrees
from
$40.99

(3)

Standard Thermostat: With Seals, 180, 185 Degrees

“Product was correct! Repair went well”

FAQs for 2021 Chevrolet Silverado 2500 HD Cooling and Climate Controls

Which Cooling and Climate Controls are best-sellers for 2021 Chevrolet Silverado 2500 HDs?

Out of 32 Cooling and Climate Controls that fit 2021 Chevrolet Silverado 2500 HDs, the following parts are the top sellers:

What’s the price range for 2021 Chevrolet Silverado 2500 HD Cooling and Climate Controls?

Cooling and Climate Control prices for the 2021 Chevrolet Silverado 2500 HD start at $4.85 and go up to $576.99 for the most premium parts.

What’s the average price of a Cooling and Climate Control for a 2021 Chevrolet Silverado 2500 HD?

The average price for Cooling and Climate Controls for the 2021 Chevrolet Silverado 2500 HD is $60.67. Keep in mind the variety of part types within our Cooling and Climate Control category so you are likely to find a wide range of prices across a variety of parts and components.

Does Advance Auto Parts sell Cooling and Climate Controls for other Chevrolet Silverado 2500 HD model years?

Yes, we currently carry Cooling and Climate Controls for 24 model years of Chevrolet Silverado 2500 HDs between 2001 and 2025. Cooling and Climate Controls are bought most frequently for the following model years: 2023, 2022, 2020, 2019, 2018, 2017, 2016, 2015, and 2014.

What are the cheapest Cooling and Climate Controls for my 2021 Chevrolet Silverado 2500 HD?

The cheapest 2021 Chevrolet Silverado 2500 HD Cooling and Climate Controls we carry in stock are:

What are the top-rated Cooling and Climate Controls that fit the 2021 Chevrolet Silverado 2500 HD?

Out of 415 reviews by customers, our 2021 Chevrolet Silverado 2500 HD Cooling and Climate Controls have an average customer rating of . These are some of the highest-rated Cooling and Climate Control types for the 2021 Chevrolet Silverado 2500 HD and their top-rated products:

What types of Cooling and Climate Controls do you sell for my 2021 Chevrolet Silverado 2500 HD?

As of 2/5/25, these are some of the most in-demand types of Cooling and Climate Controls for a 2021 Chevrolet Silverado 2500 HD:

Can I get help with 2021 Chevrolet Silverado 2500 HD Cooling and Climate Control orders?

Contact our customer support team, by chat or phone, through the help desk page, where you can find instant answers about Chevrolet Cooling and Climate Controls and more.

What is your return policy for Chevrolet Silverado 2500 HD Cooling and Climate Controls?

Advance Auto Parts keeps returns simple. For new Chevrolet Silverado 2500 HD Cooling and Climate Controls and accessories, your online orders can be returned, in their original condition, within 45 days. For requirements, see the returns page.