2016 Mercedes-Benz E250 Drivetrains

Please Select your Vehicle to See Exact Fit Parts

Essential Drivetrains for 2016 Mercedes-Benz E250s

Valvoline – Valvoline Multi-Vehicle (ATF) Full Synthetic Automatic Transmission Fluid 1 GA, 904891 (Part No.904891)

Valvoline Multi-Vehicle (ATF) Full Synthetic Automatic Transmission Fluid 1 GA, 904891

from

$35.99
Choosing an automatic transmission fluid just got easier. Valvoline Full Synthetic MaxLife Multi-Vehicle ATF, the #1 ATF product, is suitable for use in 95% of ATF vehicles in operation with US registered light duty applications. And now, it€™s also recommended for most belt and chain-driven continuously variable transmissions (CVT). Featuring advanced additives to prevent the major causes of transmission breakdown, it€™s designed to help prevent leaks, reduce wear and tear, and maximize performance €“ all for much longer than conventional fluids. It has improved thermal stability for longer fluid life, better viscosity stability for consistent transmission operation, and frictional enhancements for smooth gear engagements. Whether your vehicle has a CVT or traditional automatic, Valvoline MaxLife Multi-Vehicle ATF is suitable for a broad range of transmissions including Ford, GM, Toyota, Honda, Nissan, Hyundai, Subaru, BMW, Mercedes, Volvo, VW and Audi vehicles. It€™s specifically recommended for use in the following applications: GM DEXRON-II, DEXRON-III, DEXRON-VI, and DEX-CVT; Ford MERCON LV; Toyota/Lexus Type T, T-II, T-IV, WS, CVTF FE, and CVTF TC. For the many miles ahead, trust your transmission with Valvoline, the #1 automatic transmission fluid brand.
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National – National Differential Pinion Seal, 710996 (Part No.710996)

National Differential Pinion Seal, 710996

from

$33.49
National has built a reputation as one of the most respected names in the industry. We have offered premium sealing solutions for more than 75 years. Our design team keeps pace with the industry and provides advanced solutions for today’s vehicles.
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Dorman – Dorman Drive Shaft: Adjustable, 938-265 (Part No.938-265)

Dorman Drive Shaft: Adjustable, 938-265

from

$664.99
Upgrade and simplify your driveshaft replacement with a premium driveshaft that’s delivered fully assembled, dynamically pre-balanced and ready for a fast, hassle-free installation on specified vehicle makes, models and years. Engineered and manufactured in the USA, the driveshaft is manufactured from high-precision, drawn over mandrel (DOM) seamless steel tubing that offers superior concentricity, uniform wall thickness and greater torsional strength and dent resistance than standard welded steel. The assembly includes 100% new-not remanufactured-components, including yokes, CV joints and U-joints. A premium quality driveshaft assembly deserves premium packaging; this product ships in protective foam-in-place packaging to ensure it arrives in the same pristine, install-ready condition in which it left the manufacturing facility.
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Rein – Rein Drive Shaft Support Bearing, BEM0039P (Part No.BEM0039P)

Rein Drive Shaft Support Bearing, BEM0039P

from

$16.99
Rein Drive Shaft Support Bearing, BEM0039P.
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MOOG Driveline Products – MOOG Driveline Products Drive Shaft Coupler, 680 (Part No.680)

MOOG Driveline Products Drive Shaft Coupler, 680

from

$131.99
Designed to restore ride quality and reduce noise, vibration and harshness, MOOG premium driveline couplers are the perfect replacement for worn or deteriorated OE couplers.
See More

Carquest Premium – Carquest CV Axle Assembly, NCV48022 (Part No.NCV48022)

Carquest CV Axle Assembly, NCV48022

from

$188.99
Carquest Premium constant velocity (C.V.) axle shaft assemblies are 100% new units that are designed to meet or exceed OE specifications. Every part number is tested to guarantee a proper fit and reliable performance. Carquest Premium CV axles are assembled with a specially formulated high-temperature moly grease to resist friction and wear of the bearings and joints. Our strict engineering and quality specifications ensure a long-lasting repair that is guaranteed with an industry-leading warranty.
See More

Carquest Premium – Carquest CV Axle Assembly, NCV48068 (Part No.NCV48068)

Carquest CV Axle Assembly, NCV48068

from

$174.99
Carquest Premium constant velocity (C.V.) axle shaft assemblies are 100% new units that are designed to meet or exceed OE specifications. Every part number is tested to guarantee a proper fit and reliable performance. Carquest Premium CV axles are assembled with a specially formulated high-temperature moly grease to resist friction and wear of the bearings and joints. Our strict engineering and quality specifications ensure a long-lasting repair that is guaranteed with an industry-leading warranty.
See More

Carquest Premium – Carquest CV Axle Shaft Assembly, NCV48016 (Part No.NCV48016)

Carquest CV Axle Shaft Assembly, NCV48016

from

$193.99
Carquest Premium constant velocity (C.V.) axle shaft assemblies are 100% new units that are designed to meet or exceed OE specifications. Every part number is tested to guarantee a proper fit and reliable performance. Carquest Premium CV axles are assembled with a specially formulated high-temperature moly grease to resist friction and wear of the bearings and joints. Our strict engineering and quality specifications ensure a long-lasting repair that is guaranteed with an industry-leading warranty.
See More

National – National Axle Differential Seal, 711050 (Part No.711050)

National Axle Differential Seal, 711050

from

$30.49
National has built a reputation as one of the most respected names in the industry. We have offered premium sealing solutions for more than 75 years. Our design team keeps pace with the industry and provides advanced solutions for today’s vehicles.
See More

Rein – Rein Driveshaft Boot, BKD0066R (Part No.BKD0066R)

Rein Driveshaft Boot, BKD0066R

from

$6.99
Boot kits protect a joint in the car that would be destroyed by dirt, sand and other particles if left exposed, even under normal conditions so it’s important that they be properly maintained and in good condition. Rein Automotive provides application specific driveshaft boot kits that come guaranteed to fit the first time.
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Upgrade your 2016 Mercedes-Benz E250 with Top-Quality Drivetrains

When it comes to maintaining or upgrading your 2016 Mercedes-Benz E250, nothing is more important than using high-quality OEM or aftermarket parts that you can trust. Whether you’re repairing damage to your Mercedes-Benz or enhancing its overall performance, Drivetrains are key to keeping your E250 functioning at its best. At Advance Auto Parts, we offer a wide selection of 10 Drivetrains for the 2016 Mercedes-Benz E250, designed to meet your needs without breaking the bank. From Differential replacements to Drive Shafts and Axles upgrades, we’ve got you covered with parts that fit your vehicle perfectly and ensure long-lasting performance.

Affordable Prices and Wide Selection

Shopping for Drivetrains for any vehicle can be a hassle, especially if you’re on a budget. But with Advance Auto Parts, you can find high-quality Drivetrains for your 2016 Mercedes-Benz E250 at great prices. Our Drivetrains inventory for this model ranges from just $6.99 to $664.99, with an average price of $106.86. Our 10 Drivetrains in stock come from 6 trusted brands, so you’re sure to find the right part for your 2016 Mercedes-Benz E250 without overspending.

Explore Related Parts and More

While you’re here, don’t forget to check out other essential categories that go hand in hand with Drivetrain upgrades. Explore related part types like Batteries and Chargers, Oil and Lubricants and more to make sure your 2016 Mercedes-Benz E250 is always ready to roll. We’re committed to providing you with everything you need to keep your E250 in top shape, all in one place. Start shopping confidently below for your 2016 Mercedes-Benz E250!

Best-Selling Differentials for 2016 Mercedes-Benz E250s

Enhance the driving experience in your Mercedes-Benz with 3 quality Differential components, starting at $30.49.

Valvoline – Valvoline Multi-Vehicle (ATF) Full Synthetic Automatic Transmission Fluid 1 GA, 904891 (Part No.904891)

Valvoline Multi-Vehicle (ATF) Full Synthetic Automatic Transmission Fluid 1 GA, 904891

from

$35.99
Choosing an automatic transmission fluid just got easier. Valvoline Full Synthetic MaxLife Multi-Vehicle ATF, the #1 ATF product, is suitable for use in 95% of ATF vehicles in operation with US registered light duty applications. And now, it€™s also recommended for most belt and chain-driven continuously variable transmissions (CVT). Featuring advanced additives to prevent the major causes of transmission breakdown, it€™s designed to help prevent leaks, reduce wear and tear, and maximize performance €“ all for much longer than conventional fluids. It has improved thermal stability for longer fluid life, better viscosity stability for consistent transmission operation, and frictional enhancements for smooth gear engagements. Whether your vehicle has a CVT or traditional automatic, Valvoline MaxLife Multi-Vehicle ATF is suitable for a broad range of transmissions including Ford, GM, Toyota, Honda, Nissan, Hyundai, Subaru, BMW, Mercedes, Volvo, VW and Audi vehicles. It€™s specifically recommended for use in the following applications: GM DEXRON-II, DEXRON-III, DEXRON-VI, and DEX-CVT; Ford MERCON LV; Toyota/Lexus Type T, T-II, T-IV, WS, CVTF FE, and CVTF TC. For the many miles ahead, trust your transmission with Valvoline, the #1 automatic transmission fluid brand.
See More

National – National Differential Pinion Seal, 710996 (Part No.710996)

National Differential Pinion Seal, 710996

from

$33.49
National has built a reputation as one of the most respected names in the industry. We have offered premium sealing solutions for more than 75 years. Our design team keeps pace with the industry and provides advanced solutions for today’s vehicles.
See More

National – National Axle Differential Seal, 711050 (Part No.711050)

National Axle Differential Seal, 711050

from

$30.49
National has built a reputation as one of the most respected names in the industry. We have offered premium sealing solutions for more than 75 years. Our design team keeps pace with the industry and provides advanced solutions for today’s vehicles.
See More

Most Popular 2016 Mercedes-Benz E250 Drive Shafts and Axles

Customize your Mercedes-Benz with 7 Drive Shafts and Axles products like Drive Shaft and Axles, Center Support Bearings, and Drive and Prop Shaft Assemblies, all priced under $664.99.

Rein – Rein Drive Shaft Support Bearing, BEM0039P (Part No.BEM0039P)

Rein Drive Shaft Support Bearing, BEM0039P

from

$16.99
Rein Drive Shaft Support Bearing, BEM0039P.
See More

Rein – Rein Driveshaft Boot, BKD0066R (Part No.BKD0066R)

Rein Driveshaft Boot, BKD0066R

from

$6.99
Boot kits protect a joint in the car that would be destroyed by dirt, sand and other particles if left exposed, even under normal conditions so it’s important that they be properly maintained and in good condition. Rein Automotive provides application specific driveshaft boot kits that come guaranteed to fit the first time.
See More

Dorman – Dorman Drive Shaft: Adjustable, 938-265 (Part No.938-265)

Dorman Drive Shaft: Adjustable, 938-265

from

$664.99
Upgrade and simplify your driveshaft replacement with a premium driveshaft that’s delivered fully assembled, dynamically pre-balanced and ready for a fast, hassle-free installation on specified vehicle makes, models and years. Engineered and manufactured in the USA, the driveshaft is manufactured from high-precision, drawn over mandrel (DOM) seamless steel tubing that offers superior concentricity, uniform wall thickness and greater torsional strength and dent resistance than standard welded steel. The assembly includes 100% new-not remanufactured-components, including yokes, CV joints and U-joints. A premium quality driveshaft assembly deserves premium packaging; this product ships in protective foam-in-place packaging to ensure it arrives in the same pristine, install-ready condition in which it left the manufacturing facility.
See More

Carquest Premium – Carquest CV Axle Shaft Assembly, NCV48016 (Part No.NCV48016)

Carquest CV Axle Shaft Assembly, NCV48016

from

$193.99
Carquest Premium constant velocity (C.V.) axle shaft assemblies are 100% new units that are designed to meet or exceed OE specifications. Every part number is tested to guarantee a proper fit and reliable performance. Carquest Premium CV axles are assembled with a specially formulated high-temperature moly grease to resist friction and wear of the bearings and joints. Our strict engineering and quality specifications ensure a long-lasting repair that is guaranteed with an industry-leading warranty.
See More

Carquest Premium – Carquest CV Axle Assembly, NCV48022 (Part No.NCV48022)

Carquest CV Axle Assembly, NCV48022

from

$188.99
Carquest Premium constant velocity (C.V.) axle shaft assemblies are 100% new units that are designed to meet or exceed OE specifications. Every part number is tested to guarantee a proper fit and reliable performance. Carquest Premium CV axles are assembled with a specially formulated high-temperature moly grease to resist friction and wear of the bearings and joints. Our strict engineering and quality specifications ensure a long-lasting repair that is guaranteed with an industry-leading warranty.
See More

Carquest Premium – Carquest CV Axle Assembly, NCV48068 (Part No.NCV48068)

Carquest CV Axle Assembly, NCV48068

from

$174.99
Carquest Premium constant velocity (C.V.) axle shaft assemblies are 100% new units that are designed to meet or exceed OE specifications. Every part number is tested to guarantee a proper fit and reliable performance. Carquest Premium CV axles are assembled with a specially formulated high-temperature moly grease to resist friction and wear of the bearings and joints. Our strict engineering and quality specifications ensure a long-lasting repair that is guaranteed with an industry-leading warranty.
See More

MOOG Driveline Products – MOOG Driveline Products Drive Shaft Coupler, 680 (Part No.680)

MOOG Driveline Products Drive Shaft Coupler, 680

from

$131.99
Designed to restore ride quality and reduce noise, vibration and harshness, MOOG premium driveline couplers are the perfect replacement for worn or deteriorated OE couplers.
See More

FAQs for 2016 Mercedes-Benz E250 Drivetrains

Which Drivetrains are best-sellers for 2016 Mercedes-Benz E250s?

Out of 10 Drivetrains that fit 2016 Mercedes-Benz E250s, the following parts are the top sellers:

What’s the price range for 2016 Mercedes-Benz E250 Drivetrains?

Drivetrain prices for the 2016 Mercedes-Benz E250 start at $6.99 and go up to $664.99 for the most premium parts.

What’s the average price of a Drivetrain for a 2016 Mercedes-Benz E250?

The average price for Drivetrains for the 2016 Mercedes-Benz E250 is $106.86. Keep in mind the variety of part types within our Drivetrain category so you are likely to find a wide range of prices across a variety of parts and components.

Does Advance Auto Parts sell Drivetrains for other Mercedes-Benz E250 model years?

Yes, we currently carry Drivetrains for 1 model years of Mercedes-Benz E250s between 2014 and 2015. Drivetrains are bought most frequently for the following model years: 2015 and 2014.

What are the cheapest Drivetrains for my 2016 Mercedes-Benz E250?

The cheapest 2016 Mercedes-Benz E250 Drivetrains we carry in stock are:

What types of Drivetrains do you sell for my 2016 Mercedes-Benz E250?

As of 8/2/26, these are some of the most in-demand types of Drivetrains for a 2016 Mercedes-Benz E250:

Can I get help with 2016 Mercedes-Benz E250 Drivetrain orders?

Contact our customer support team, by chat or phone, through the help desk page, where you can find instant answers about Mercedes-Benz Drivetrains and more.

What is your return policy for Mercedes-Benz E250 Drivetrains?

Advance Auto Parts keeps returns simple. For new Mercedes-Benz E250 Drivetrains and accessories, your online orders can be returned, in their original condition, within 45 days. For requirements, see the returns page.