2012 Mercedes-Benz E350 Engine Cooling Parts

Please Select your Vehicle to See Exact Fit Parts

Keep Your 2012 Mercedes-Benz E350 in Top Shape with Quality Engine Cooling Parts

Whether you’re repairing or upgrading your Engine Cooling Part, using high-quality parts is key to keeping your 2012 Mercedes-Benz E350 looking sharp and performing at its best. At Advance Auto Parts we carry a wide selection of dependable options, including Thermostat and Water Outlet Assemblies, Radiators, and Water Pumps. Whether you’re replacing a damaged part or enhancing your truck’s style and protection, you’ll find exactly what you need to get the job done right.

Top-Rated Engine Cooling Parts from Trusted Brands

Looking for a reliable Engine Cooling Part? We’ve got you covered with options from brands you know and trust like Carquest Premium. For example, Carquest Premium Engine Cooling Parts start at just $19.99 with an average 4.4 star rating. With over 6 reviews and a solid 5 star average, you can shop with confidence knowing other Mercedes-Benz E350 owners approve.

Competitive Prices and Extensive Inventory

The average price for a 2012 Mercedes-Benz E350 Engine Cooling Part at Advance Auto Parts is around $147.20, with a range that starts at $4.99 and goes up to $513.99. With 21 options in stock from 5 trusted brands, finding the right fit is easy. Popular picks like Coolant Temperature Sensor 1TS1049, Integrated Thermostat Housing: With Seal, 189 Degrees, and Radiator start at just $21.99 and offer a great balance of form and function.

Explore Related Parts

While you’re upgrading or replacing your Engine Cooling Part, don’t forget to check out other key components like Blower Motor and Related Products and HVAC Electrical Parts. At Advance Auto Parts, we’re here to help you keep your 2012 Mercedes-Benz E350 in peak condition, inside and out.

Essential 2012 Mercedes-Benz E350 Engine Cooling Parts

KAI – Radiator (Part No.RAD2868)

Radiator

from

$169.99
New Platinum Pro Radiator, 3.2 And 3.5 Liter Engines, Without PZEV Emissions Package

Product Features:
  • 3.2 And 3.5 Liter Engines, Without PZEV Emissions Package, Made Of Plastic and Aluminum
  • Meets All Federal Motor Safety Standards
  • No Drilling Needed For Installation
  • No Modifications Needed For Installation
  • Direct Fit Replacement For Your Vehicle
  • Same Form Fit And Function As OE
  • Warranty: 5 Year, Limited
  • Radiator Cap Not Included
  • Check Out The Large Selection Of Parts Available For Your Vehicle
See More

Carquest Premium – Radiator (Part No.812868)

Radiator

from

$249.99
Carquest Premium Radiators offer one of the largest product ranges in the aftermarket, covering more than 95% of the popular automotive and light truck applications. Carquest Premium Radiators meet or exceed original equipment specifications, ensuring that products fit and perform just as well or better than the original parts, providing you peace of mind.

Product Features:
  • Our B-type tubes feature central reinforcement to provide greater tolerance to pressure. Stronger tube design means drastically reduced probability of tube failure.
  • Our deep extrusion header provides a stronger tube to header joint which is more resistant to the effects of vibration and thermal tube expansion, virtually eliminating tube to header leaks.
  • Our fin edges are folded for increased stability and heat disbursement properties.
  • Our included “multi-fit” attachments allow one radiator to cover multiple vehicle applications without sacrificing OE fit. This results in wider vehicle coverage with substantially less inventory.
  • Thermal expansion cuts allow for longer life and reduce failure rates by allowing improved core expansion and contraction during normal heat cycles.
  • We design and manufacture all our radiators to meet or even exceed Original Equipment specifications. We take pride in producing the most reliable replacement parts in the market.
  • We use longer header tabs for increased pressure resistance. This reduces the potential for tank to header leaks.
See More

Rein – Thermostat Assembly 100C (Part No.CTA0020)

Thermostat Assembly 100C

from

$148.99
Rein Automotive OE quality thermostat assemblies install, fit and perform the way the original manufacturer intended. These assemblies are designed to meet or exceed the OE materials used. Rein thermostat housings are constructed of metal or plastic based on vehicle specific factory requirements. The housings are constructed from molds cast directly from the OEM parts to meet the strict tolerances of the vehicle’s factory specifications. This ensures a smooth and easy installation, just as one would expect to find with OE quality. Rein thermostats are produced with high-quality metals and components to ensure proper durability and service life. The thermostats are temperature calibrated to have a consistent and precise response suiting cooling system needs. Our quality thermostat assemblies aim to provide the profession repair technician and vehicle owner the peace of mind and trust that is expected from an OE quality component.

Product Features:
  • Matches original equipment design specifications
  • All gaskets or seals necessary for installation are supplied with thermostats
  • Manufactured to strict engineering standards/specifications in materials and tolerances
  • Thermostat set to 100 degrees Celsius to maintain optimal running temperature
See More

Motorad – Integrated Thermostat Housing: With Seal, 189 Degrees (Part No.623-189)

Integrated Thermostat Housing: With Seal, 189 Degrees

from

$61.99
Manufactured with OEM quality materials and safety standards by an OE Supplier. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant. Offset design, air relief valve, and OEM style seals included where applicable

Product Features:


    Product Features:
    • High grade stainless steel and copper construction
    • Meets or exceeds OEM standards
    • Consistent and precise response to cooling system needs
    • Original equipment design for worry-free direct fit replacement
    • 100% tested and calibrated
See More

Rein – Radiator Mount (Part No.AVM0699)

Radiator Mount

from

$22.99
Anti-vibration parts dampen vibration harmonics from the engine and drive line components to rest of the vehicle. This in turn reduces vibration and noise which can be felt and heard while the vehicle is in operation. Rein Automotive anti-vibration parts are application specific and match the design and function of the OE parts.

Product Features:
  • Rubber components match the shore hardness of the original equipment bushing to ensure maximum performance and product longevity.
  • Part has a high corrosion resistance for maximum life.
  • Produced with high quality materials to ensure maximum life and a smooth ride.
  • Made by the OE manufacturer.
See More

Dorman – RAD MOUNT BUSHING (Part No.927-245)

RAD MOUNT BUSHING

from

$17.99
RAD MOUNT BUSHING

Dorman – Auxiliary Coolant Pump (Part No.902-065)

Auxiliary Coolant Pump

from

$215.99
This engine auxiliary water pump is designed to match the fit and function of the original pump on specified applications, and is engineered for reliable performance and durability.

Product Features:
  • Direct replacement – this engine auxiliary water pump is designed to match the fit and function of the original pump on specified applications
  • Restores functionality – reliable replacement for an original pump that has failed to provide sufficient water flow
  • Durable construction – this part is made from quality materials to ensure reliable performance and long service life
  • Trustworthy quality – backed by team of product experts in the United States and more than a century of automotive experience
See More

Carquest Premium – Engine Auxiliary Water Pump_New (Part No.T1395)

Engine Auxiliary Water Pump_New

from

$499.99
This new pump is 100% tested to ensure the highest quality. Each unit is built to meet or exceed all OE specifications and is validated for fit, form, and function. Application specific design to ensure a perfect fit and correct operation for unsurpassed quality.

Product Features:
  • Electric water pump
  • Specialized for vehicles using supplemented cooling for the engine or components
  • Plastic housing
  • All components necessary for installation are supplied with pump
See More

URO Parts – Thermostat Assembly w/o temp sensor (Part No.2762000515)

Thermostat Assembly w/o temp sensor

from

$73.99
For European vehicles, A.P.A. manufactures the URO Parts brand of quality replacement parts, which meet or exceed OEM specifications. URO Parts components are ideal for both professional and DIY vehicle repair, and are often the exclusive aftermarket alternative to overpriced ¿Genuine¿ components. By reducing deferred maintenance with URO Parts, you will increase the bottom line of your business. With its URO Premium line, A.P.A. offers problem-solving upgraded components that are superior to failure-prone OEM parts in design and/or materials. A.P.A. is so confident in the longevity and reliability of URO Premium products, . URO Parts also specializes in accurate reproduction parts for classic vehicles, including a huge variety of items that are no longer available from the dealer.

Product Features:
  • Guaranteed fitment
  • High-flow OE-style design for optimal engine cooling performance
  • Thermostat housing assembly is manufactured to factory housing dimensions for easy bolt-on installation and reliable hose connections
  • Includes temperature sensor where applicable
  • High-quality alloy or composite material is temperature-stable to resist warping or cracking that can lead to coolant leakage
See More

Carquest Premium – Standard Reservoir Cap: 21 PSI (Part No.10253)

Standard Reservoir Cap: 21 PSI

from

$19.99
Crafted to meet the exact specifications set by Original Equipment Manufacturers (OEM), these products are engineered for effortless installation and removal. Constructed from premium-grade components, incorporating proper relief and vacuum valves, they ensure optimal performance even in the most demanding automotive cooling systems. Rigorously quality-tested, these components provide exceptional, out-of-the-box performance and superior durability to meet or exceed the highest standards of today’s vehicles.

Product Features:
  • Maintains proper cooling system pressure
  • Easy installation and removal
  • 100% tested to ensure proper pressure and longevity
  • Meets all OEM specifications
See More

Rein – Cap-Expansion Tank (Part No.CPE0029P)

Cap-Expansion Tank

from

$32.99
Rein Automotive OE Quality expansion tank caps are designed to be direct replacements for OE caps. Rein caps are designed to match or exceed the OE materials used and are produced to the highest standards to ensure long service life. Rein Automotive OE quality expansion tank caps keep the coolant system at the proper pressure just like the OE cap.

Product Features:
  • Manufactured to strict engineering standards/specifications in materials and tolerances.
  • Direct fit.
  • Meets or exceeds pressure specifications demanded by the OE manufacturer.
  • Produced by an original equipment supplier.
See More

Motorad – Integrated Thermostat Housing: With Sensor, With Gasket, 212 Degrees (Part No.668-212)

Integrated Thermostat Housing: With Sensor, With Gasket, 212 Degrees

from

$117.99
Manufactured with OEM quality materials and safety standards by an OE Supplier. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant. Offset design, air relief valve, and OEM style seals included where applicable.

Product Features:
  • High grade stainless steel and copper construction
  • Meets or exceeds OEM standards
  • Consistent and precise response to cooling system needs
  • Original equipment design for worry-free direct fit replacement
  • 100% tested and calibrated
See More

Dorman – Thermostat Assembly: Includes Gasket, Housing, and Thermostat (Part No.902-5183)

Thermostat Assembly: Includes Gasket, Housing, and Thermostat

from

$45.99
This replacement engine coolant thermostat housing is engineered to match the fit and durability of the stock thermostat housing on specified vehicles. It is designed to withstand extreme temperature changes to extend service life.

Product Features:
  • Ideal replacement – this engine coolant thermostat housing directly replaces the original housing on specified vehicle years, makes and models
  • Durable construction – this part is specifically designed to withstand extreme temperature changes and resist cracking and leaking
  • Cost-effective and reliable – offers original manufacturer quality at lower cost than getting replacement at dealer
  • Industry-leading design – professionally engineered by the aftermarket leader in replacement thermostat housings
See More

Dorman – Thermostat Assembly: Includes Housing, Gasket, and Sensor, 212 Degrees (Part No.902-5912)

Thermostat Assembly: Includes Housing, Gasket, and Sensor, 212 Degrees

from

$192.99
This replacement engine coolant thermostat housing is engineered to match the fit and durability of the stock thermostat housing on specified vehicles. It is designed to withstand extreme temperature changes to extend service life.

Product Features:
  • Ideal replacement – this engine coolant thermostat housing directly replaces the original housing on specified vehicle years, makes and models
  • Durable construction – this part is specifically designed to withstand extreme temperature changes and resist cracking and leaking
  • Cost-effective and reliable – offers original manufacturer quality at lower cost than getting replacement at dealer
  • Industry-leading design – professionally engineered by the aftermarket leader in replacement thermostat housings
See More

Carquest Premium – Coolant Temperature Sensor 1TS1049 (Part No.WTC1122)

Coolant Temperature Sensor 1TS1049

from

$21.99
Product Features:
  • Designed to meet or exceed OE specifications for fit, form and function
  • 100% factory resistance calibrated to ensure precision tolerances, resulting in extremely accurate temperature for optimal performance
  • OE precision matched thermistor ensuring Carquest sensors match OE output resistances across all temperature positions
  • O-rings, seals or thread sealant are included if required
  • Weather-tight connectors prevent leaks and corrosion for longer life
  • Extensive design validation testing and 100% end-of-line tested
  • Carquest Vehicle Solutions Technical Support available from ASE certified technicians: 1-866-687-5413
See More

URO Parts – EAC Temperature Sensor (Part No.221905560080)

EAC Temperature Sensor

from

$119.99
For European vehicles, A.P.A. manufactures the URO Parts brand of quality replacement parts, which meet or exceed OEM specifications. URO Parts components are ideal for both professional and DIY vehicle repair, and are often the exclusive aftermarket alternative to overpriced ¿Genuine¿ components. By reducing deferred maintenance with URO Parts, you will increase the bottom line of your business. With its URO Premium line, A.P.A. offers problem-solving upgraded components that are superior to failure-prone OEM parts in design and/or materials. A.P.A. is so confident in the longevity and reliability of URO Premium products, . URO Parts also specializes in accurate reproduction parts for classic vehicles, including a huge variety of items that are no longer available from the dealer.

Product Features:
  • Guaranteed fitment
  • Direct-fit OE replacement design restores proper factory cooling fan sensor function
  • Easy plug-and-play connection
  • Manufactured using high-quality materials to withstand intense engine compartment and cooling system heat
  • Alloy conductors minimize electrical resistance for accurate operation
  • Designed and tested for reliability and long life
See More

Carquest Premium – Engine Water Pump: New (Part No.T3124)

Engine Water Pump: New

from

$265.99
The Carquest New Water Pump features all new, original equipment-quality components for proper fit and long-life performance. Each pump includes heavy-duty unitized bearings, pressed-on hubs, precision machined housings, unitized seals and optimal impeller clearance, plus all new water pumps are 100% factory tested to assure the highest quality product. Each unit is built to meet or exceed all Original Equipment specifications and is validated for fit, form, and function. Also, application specific design to ensure a perfect fit and correct operation for unsurpassed quality that you can trust.

Product Features:
  • 100% tested for reliable performance
  • Durable housing features precisely machined mounting surface for proper sealing and fitment
  • Equipped with weep chamber or similar feature to help prevent unnecessary replacement
  • Included heavy-duty unitized bearings, pressed-on hubs and optimal impeller clearance for a long-lasting water pump
  • All gaskets or seals necessary for water pump are included
  • This pump is driven by the accessory belt and we recommend replacement if nearing service recommendation
  • Additional Notes: Includes gasket
See More

Carquest Premium – Engine Auxiliary Water Pump_New (Part No.T1380)

Engine Auxiliary Water Pump_New

from

$247.99
This new pump is 100% tested to ensure the highest quality. Each unit is built to meet or exceed all OE specifications and is validated for fit, form, and function. Application specific design to ensure a perfect fit and correct operation for unsurpassed quality.

Product Features:
  • Electric water pump
  • Specialized for vehicles using supplemented cooling for the engine or components
  • Plastic housing
  • All components necessary for installation are supplied with pump
See More

Carquest Premium – Engine Water Pump: New, Gasket/Seals Included (Part No.T3128)

Engine Water Pump: New, Gasket/Seals Included

from

$204.99
This premium water pump uses new high-quality components and is designed to meet or exceed OE specifications. This pump is 100% tested to ensure quality. Bearings, gaskets, seals, impeller, hub and housing are all designed for long-lasting service life. All necessary gaskets and seals are included.

Product Features:
  • 100% tested for reliable performance
  • Durable housing features precisely machined mounting surface for proper sealing and fitment
  • Equipped with weep chamber or similar feature to help prevent unnecessary replacement
  • Included heavy-duty unitized bearings, pressed-on hubs and optimal impeller clearance for a long-lasting water pump
  • All gaskets or seals necessary for water pump are included
  • This pump is driven by the accessory belt and we recommend replacement if nearing service recommendation
  • This pump is driven by the timing chain; see vehicle manufacturer recommendation for replacement of timing components
  • This pump is driven by the timing belt; see vehicle manufacturer recommendation for replacement of timing components
  • Additional Notes: Includes gasket
See More

Carquest Premium – Engine Water Pump: New (Part No.T2288)

Engine Water Pump: New

from

$179.99
This premium water pump uses new high-quality components and is designed to meet or exceed OE specifications. This pump is 100% tested to ensure quality. Bearings, gaskets, seals, impeller, hub and housing are all designed for long-lasting service life. All necessary gaskets and seals are included.

Product Features:
  • 100% tested for reliable performance
  • Durable housing features precisely machined mounting surface for proper sealing and fitment
  • Equipped with weep chamber or similar feature to help prevent unnecessary replacement
  • Included heavy-duty unitized bearings, pressed-on hubs and optimal impeller clearance for a long-lasting water pump
  • All gaskets or seals necessary for water pump are included
  • This pump is driven by the accessory belt and we recommend replacement if nearing service recommendation
  • This pump is driven by the timing chain; see vehicle manufacturer recommendation for replacement of timing components
  • This pump is driven by the timing belt; see vehicle manufacturer recommendation for replacement of timing components
  • Additional Notes: Includes gasket
See More

Rein – Expansion Tank (Part No.EPT0029)

Expansion Tank

from

$63.99
Rein Automotive OE quality expansion tanks, install, fit and perform the way the original manufacturer intended. These tanks are designed to match or exceed the OE materials used and are produced from virgin plastic with no regrind to prevent cracking from heat cycles and ensure the plastic is durable and will have a long service life.

Product Features:
  • Produced from virgin plastic meeting/exceeding OE specifications and ensuring long life
  • Resistant to cracking and wear from heat cycles preventing coolant loss
  • Direct fitment allows easy installation
  • Manufactured to strict engineering standards/specifications in materials and tolerances
See More

Rein – Expansion Tank (Part No.EPT0132)

Expansion Tank

from

$63.99
Rein Automotive OE quality expansion tanks, install, fit and perform the way the original manufacturer intended. These tanks are designed to match or exceed the OE materials used and are produced from virgin plastic with no regrind to prevent cracking from heat cycles and ensure the plastic is durable and will have a long service life.

Product Features:
  • Produced from virgin plastic meeting/exceeding OE specifications and ensuring long life
  • Resistant to cracking and wear from heat cycles preventing coolant loss
  • Direct fitment allows easy installation
  • Manufactured to strict engineering standards/specifications in materials and tolerances
See More

Dorman – Pressurized Coolant Reservoir: Black and Clear, Plastic, Original Equipment Replacement (Part No.603-257)

Pressurized Coolant Reservoir: Black and Clear, Plastic, Original Equipment Replacement

from

$65.99
This replacement engine coolant reservoir is manufactured from quality materials to withstand the stresses of underhood heat and engine vibration. It is engineered and manufactured to match the fit and function of the original part.

Product Features:
  • Direct replacement – this engine coolant reservoir matches the fit and function of the original part
  • Ideal solution – engineered for a seamless installation
  • Durable construction – manufactured from quality materials to withstand underhood heat and vibration
  • Trustworthy design – backed by 100 years of automotive aftermarket experience
See More

URO Parts – Expansion Tank (Part No.2045000749)

Expansion Tank

from

$23.99
For European vehicles, A.P.A. manufactures the URO Parts brand of quality replacement parts, which meet or exceed OEM specifications. URO Parts components are ideal for both professional and DIY vehicle repair, and are often the exclusive aftermarket alternative to overpriced ¿Genuine¿ components. By reducing deferred maintenance with URO Parts, you will increase the bottom line of your business. With its URO Premium line, A.P.A. offers problem-solving upgraded components that are superior to failure-prone OEM parts in design and/or materials. A.P.A. is so confident in the longevity and reliability of URO Premium products, . URO Parts also specializes in accurate reproduction parts for classic vehicles, including a huge variety of items that are no longer available from the dealer.

Product Features:
  • Guaranteed fitment
  • Precision-molded to OE dimensions to ensure compatibility with original sensors and connections
  • Quality materials resist engine heat and harsh cooling system environment
  • Factory pressure-tested
See More

Dorman – Radiator Fan Assembly: Single, with Controller, Cost Effective and Reliable (Part No.621-373)

Radiator Fan Assembly: Single, with Controller, Cost Effective and Reliable

from

$513.99
This engine cooling fan assembly is precision-engineered to match the fit and performance of the stock radiator fan on specific vehicle years, makes and models. It has been rigorously tested to ensure it cools as effectively as the original part.

Product Features:
  • Ideal replacement – this engine cooling fan assembly was precision-engineered to match the fit and performance of the stock radiator fan assembly on specific vehicles
  • Complete package – assembly is designed with the same materials and components as the original part
  • Quality assured – motors are tested in laboratory settings to ensure performance
  • Cost effective and reliable – trustworthy manufacturing for far less than same part at the dealership
See More

Most Popular Thermostat and Water Outlet Assemblies for 2012 Mercedes-Benz E350s

Enhance your 2012 Mercedes-Benz E350 with one of the 2 Thermostat and Water Outlet Assemblies we have in stock, starting at just $45.99.

Motorad – Integrated Thermostat Housing: With Sensor, Spring Clip, Seal, 212 Degrees (Part No.785-212)

Integrated Thermostat Housing: With Sensor, Spring Clip, Seal, 212 Degrees

from

$263.99
Manufactured with OEM quality materials and safety standards by an OE Supplier. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant.

Product Features:
  • High grade stainless steel and copper construction
  • Meets or exceeds OEM standards
  • Consistent and precise response to cooling system needs
  • Original equipment design for worry-free direct fit replacement
  • 100% tested and calibrated
See More

Dorman – Thermostat Assembly: Includes Gasket, Housing, and Thermostat (Part No.902-5183)

Thermostat Assembly: Includes Gasket, Housing, and Thermostat

from

$45.99
This replacement engine coolant thermostat housing is engineered to match the fit and durability of the stock thermostat housing on specified vehicles. It is designed to withstand extreme temperature changes to extend service life.

Product Features:
  • Ideal replacement – this engine coolant thermostat housing directly replaces the original housing on specified vehicle years, makes and models
  • Durable construction – this part is specifically designed to withstand extreme temperature changes and resist cracking and leaking
  • Cost-effective and reliable – offers original manufacturer quality at lower cost than getting replacement at dealer
  • Industry-leading design – professionally engineered by the aftermarket leader in replacement thermostat housings
See More

Best-Selling 2012 Mercedes-Benz E350 Radiator

Upgrade your E350 with our best-selling Radiator.

Carquest Premium – Radiator (Part No.813162)

Radiator

from

$276.99
Carquest Premium Radiators offer one of the largest product ranges in the aftermarket, covering more than 95% of the popular automotive and light truck applications. Carquest Premium Radiators meet or exceed original equipment specifications, ensuring that products fit and perform just as well or better than the original parts, providing you peace of mind.

Product Features:
  • Our B-type tubes feature central reinforcement to provide greater tolerance to pressure. Stronger tube design means drastically reduced probability of tube failure.
  • Our deep extrusion header provides a stronger tube to header joint which is more resistant to the effects of vibration and thermal tube expansion, virtually eliminating tube to header leaks.
  • Our fin edges are folded for increased stability and heat disbursement properties.
  • Our included “multi-fit” attachments allow one radiator to cover multiple vehicle applications without sacrificing OE fit. This results in wider vehicle coverage with substantially less inventory.
  • Thermal expansion cuts allow for longer life and reduce failure rates by allowing improved core expansion and contraction during normal heat cycles.
  • We design and manufacture all our radiators to meet or even exceed Original Equipment specifications. We take pride in producing the most reliable replacement parts in the market.
  • We use longer header tabs for increased pressure resistance. This reduces the potential for tank to header leaks.
See More

Top-Quality Water Pumps for 2012 Mercedes-Benz E350s

Choose a high-quality OEM or aftermarket Water Pump for Mercedes-Benz E350s and enjoy top-notch performance from $179.99.

Carquest Premium – Engine Water Pump: New (Part No.T2288)

Engine Water Pump: New

from

$179.99
This premium water pump uses new high-quality components and is designed to meet or exceed OE specifications. This pump is 100% tested to ensure quality. Bearings, gaskets, seals, impeller, hub and housing are all designed for long-lasting service life. All necessary gaskets and seals are included.

Product Features:
  • 100% tested for reliable performance
  • Durable housing features precisely machined mounting surface for proper sealing and fitment
  • Equipped with weep chamber or similar feature to help prevent unnecessary replacement
  • Included heavy-duty unitized bearings, pressed-on hubs and optimal impeller clearance for a long-lasting water pump
  • All gaskets or seals necessary for water pump are included
  • This pump is driven by the accessory belt and we recommend replacement if nearing service recommendation
  • This pump is driven by the timing chain; see vehicle manufacturer recommendation for replacement of timing components
  • This pump is driven by the timing belt; see vehicle manufacturer recommendation for replacement of timing components
  • Additional Notes: Includes gasket
See More

Carquest Premium – Engine Auxiliary Water Pump_New (Part No.T1380)

Engine Auxiliary Water Pump_New

from

$247.99
This new pump is 100% tested to ensure the highest quality. Each unit is built to meet or exceed all OE specifications and is validated for fit, form, and function. Application specific design to ensure a perfect fit and correct operation for unsurpassed quality.

Product Features:
  • Electric water pump
  • Specialized for vehicles using supplemented cooling for the engine or components
  • Plastic housing
  • All components necessary for installation are supplied with pump
See More

Top Picks for 2012 Mercedes-Benz E350 Coolant Reservoirs

Invest in one of our 3 durable Coolant Reservoirs for your 2012 Mercedes-Benz, knowing you’re getting trusted brands and expert craftsmanship.

Dorman – Pressurized Coolant Reservoir: Black and Clear, Plastic, Original Equipment Replacement (Part No.603-257)

Pressurized Coolant Reservoir: Black and Clear, Plastic, Original Equipment Replacement

from

$65.99
This replacement engine coolant reservoir is manufactured from quality materials to withstand the stresses of underhood heat and engine vibration. It is engineered and manufactured to match the fit and function of the original part.

Product Features:
  • Direct replacement – this engine coolant reservoir matches the fit and function of the original part
  • Ideal solution – engineered for a seamless installation
  • Durable construction – manufactured from quality materials to withstand underhood heat and vibration
  • Trustworthy design – backed by 100 years of automotive aftermarket experience
See More

Rein – Expansion Tank (Part No.EPT0029)

Expansion Tank

from

$63.99
Rein Automotive OE quality expansion tanks, install, fit and perform the way the original manufacturer intended. These tanks are designed to match or exceed the OE materials used and are produced from virgin plastic with no regrind to prevent cracking from heat cycles and ensure the plastic is durable and will have a long service life.

Product Features:
  • Produced from virgin plastic meeting/exceeding OE specifications and ensuring long life
  • Resistant to cracking and wear from heat cycles preventing coolant loss
  • Direct fitment allows easy installation
  • Manufactured to strict engineering standards/specifications in materials and tolerances
See More

URO Parts – Expansion Tank (Part No.2045000749)

Expansion Tank

from

$23.99
For European vehicles, A.P.A. manufactures the URO Parts brand of quality replacement parts, which meet or exceed OEM specifications. URO Parts components are ideal for both professional and DIY vehicle repair, and are often the exclusive aftermarket alternative to overpriced ¿Genuine¿ components. By reducing deferred maintenance with URO Parts, you will increase the bottom line of your business. With its URO Premium line, A.P.A. offers problem-solving upgraded components that are superior to failure-prone OEM parts in design and/or materials. A.P.A. is so confident in the longevity and reliability of URO Premium products, . URO Parts also specializes in accurate reproduction parts for classic vehicles, including a huge variety of items that are no longer available from the dealer.

Product Features:
  • Guaranteed fitment
  • Precision-molded to OE dimensions to ensure compatibility with original sensors and connections
  • Quality materials resist engine heat and harsh cooling system environment
  • Factory pressure-tested
See More

Thermostats for 2012 Mercedes-Benz E350s

Make a smart move for your 2012 Mercedes-Benz E350 with products all priced from $61.99 to $262.99.

Motorad – Integrated Thermostat Housing: With Seal, 189 Degrees (Part No.623-189)

Integrated Thermostat Housing: With Seal, 189 Degrees

from

$61.99
Manufactured with OEM quality materials and safety standards by an OE Supplier. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant. Offset design, air relief valve, and OEM style seals included where applicable

Product Features:


Product Features:
  • High grade stainless steel and copper construction
  • Meets or exceeds OEM standards
  • Consistent and precise response to cooling system needs
  • Original equipment design for worry-free direct fit replacement
  • 100% tested and calibrated
See More

Motorad – Integrated Thermostat Housing: With Sensor, With Seal, 217 Degrees (Part No.785-217)

Integrated Thermostat Housing: With Sensor, With Seal, 217 Degrees

from

$262.99
Manufactured with OEM quality materials and safety standards by an OE Supplier. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant.

Product Features:
  • High grade stainless steel and copper construction
  • Meets or exceeds OEM standards
  • Consistent and precise response to cooling system needs
  • Original equipment design for worry-free direct fit replacement
  • 100% tested and calibrated
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Top-Rated Engine Cooling Part Brands For Your 2012 Mercedes-Benz E350

When it comes to finding the perfect Engine Cooling Part for your 2012 Mercedes-Benz E350, Advance Auto Parts has you covered with a wide selection of high-quality OEM and aftermarket options from 5 trusted brands. We carry the most popular Engine Cooling Part brands including Carquest Premium, and more, all known for their exceptional customer ratings (average brand rating of 4.4 stars) and competitive prices, as low as $19.99. Purchasing a Engine Cooling Part from us here at Advance Auto Parts is a smart move for both you and your 2012 Mercedes-Benz E350, providing peace of mind with parts that meet or exceed OEM standards.

Popular Carquest Premium 2012 Mercedes-Benz E350 Engine Cooling Parts

If you’re looking for a top-quality Engine Cooling Part for your 2012 Mercedes-Benz E350, Advance Auto Parts has exactly what you need with our selection of Carquest Premium Engine Cooling Parts. We have 1 Carquest Premium Engine Cooling Parts in stock for this fitment, all known for their durability and precision fit. With prices starting at just $19.99, you’ll find the perfect Engine Cooling Part for your needs and budget. Carquest Premium Engine Cooling Parts for the 2012 Mercedes-Benz E350 come highly rated, with over 1 customer reviews and an impressive average rating of 4.4 stars. Choosing a Carquest Premium Engine Cooling Part from Advance Auto Parts is a smart move to ensure quality and value for your vehicle.
Standard Reservoir Cap: 21 PSI
from $19.99
(1)
Standard Reservoir Cap: 21 PSI
“Works well, looks identical to OEM!”

FAQs for 2012 Mercedes-Benz E350 Engine Cooling Parts

What are the best-selling Engine Cooling Parts for 2012 Mercedes-Benz E350s?

Out of 21 Engine Cooling Parts that fit 2012 Mercedes-Benz E350s, the following parts are the top sellers:

What’s the price range for 2012 Mercedes-Benz E350 Engine Cooling Parts?

The prices of Engine Cooling Parts for the 2012 Mercedes-Benz E350 range from $4.99 up to $513.99 for the most premium parts.

What is the average price of an Engine Cooling Part for a 2012 Mercedes-Benz E350?

The average price for Engine Cooling Parts for the 2012 Mercedes-Benz E350 is $147.20. Keep in mind the variety of part types within our Engine Cooling Part category, where you are likely to find a wide range of prices across a variety of parts and components.

Does Advance Auto Parts sell Engine Cooling Parts for other Mercedes-Benz E350 model years?

Yes, we carry Engine Cooling Parts for 15 model years of Mercedes-Benz E350s between 2006 and 2025. The following model years are the most popular for Engine Cooling Part purchases: 2023, 2022, 2021, 2020, 2016, 2015, 2014, 2013, and 2011.

What are the cheapest Engine Cooling Parts for my 2012 Mercedes-Benz E350?

The cheapest 2012 Mercedes-Benz E350 Engine Cooling Parts we carry are:

Does Advance Auto Parts sell Engine Cooling Parts for any other 2012 Mercedes-Benz models?

Yes. We stock Engine Cooling Parts for 34 other popular 2012 Mercedes-Benz models. Some of the most popular are 2012 SLK55 AMG Engine Cooling Parts, 2012 SLK350 Engine Cooling Parts, 2012 S600 Engine Cooling Parts, 2012 C350 Engine Cooling Parts, and 2012 E550 Engine Cooling Parts.

What types of Engine Cooling Parts do you sell for my 2012 Mercedes-Benz E350?

As of 3/1/26, these are some of the most in-demand types of Engine Cooling Parts for a 2012 Mercedes-Benz E350:

Can I get help with 2012 Mercedes-Benz E350 Engine Cooling Part orders?

Contact our customer support team by chat or phone, through the help desk page, where you can find instant answers about Mercedes-Benz Engine Cooling Parts and more.

What is your return policy for Mercedes-Benz E350 Engine Cooling Parts?

Advance Auto Parts keeps returns simple. For new Mercedes-Benz E350 Engine Cooling Parts and accessories, your online orders can be returned, in their original condition, within 45 days. For requirements, see the returns page.