2006 Peterbilt 378 Fuel and Emissions Systems

Essential Fuel and Emissions Systems for 2006 Peterbilt 378s

Carquest Premium – Fuel/Water Separator: Quality Removal of Water and Contaminants from Fuel System (Part No.86472)

Fuel/Water Separator: Quality Removal of Water and Contaminants from Fuel System

from

$30.99
Carquest Premium Fuel/Water Separator Filters remove water and other impurities from the fuel before it reaches your engine fuel system. These filters effectively separate water from the fuel, preventing corrosion and damage to fuel injectors, pumps and other critical engine components. By keeping the fuel clean and water-free, these filters help ensure optimal combustion, improve engine efficiency, and reduce emissions. Carquest Premium Fuel/Water Separator Filters are designed to meet or exceed the performance requirements of the Original Equipment Manufacturer (OEM).

Product Features:
  • Designed to meet or exceed OE filter performance levels over the entire OE recommended service interval.
  • Contains Standpipe
  • Patent pending drain, metal end caps, which hold media in place
  • Rust resistant can, ensuring no leakage from inside
  • Made in USA
  • Includes Standpipe
  • CAUTION: Furnished D-Ring must be installed on post for seal.
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Carquest Premium – Fuel/Water Separator: Quality Removal of Water and Contaminants from Fuel System (Part No.96064)

Fuel/Water Separator: Quality Removal of Water and Contaminants from Fuel System

from

$35.99
Carquest Premium Fuel/Water Separator Filters remove water and other impurities from the fuel before it reaches your engine fuel system. These filters effectively separate water from the fuel, preventing corrosion and damage to fuel injectors, pumps and other critical engine components. By keeping the fuel clean and water-free, these filters help ensure optimal combustion, improve engine efficiency, and reduce emissions. Carquest Premium Fuel/Water Separator Filters are designed to meet or exceed the performance requirements of the Original Equipment Manufacturer (OEM).

Product Features:
  • Designed to meet or exceed OE filter performance levels over the entire OE recommended service interval.
  • Application engineered media which aids in stripping water in diesel fuels
  • Patent pending drain, metal end caps, which hold media in place
  • Rust resistant can, ensuring no leakage from inside
  • Made in USA
  • CAUTION: Furnished D-Ring must be installed on post for seal.
  • Use with 99185
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Carquest Premium – Fuel/Water Separator: Quality Removal of Water and Contaminants from Fuel System (Part No.86651XE)

Fuel/Water Separator: Quality Removal of Water and Contaminants from Fuel System

from

$45.99
Carquest Premium Fuel/Water Separator Filters remove water and other impurities from the fuel before it reaches your engine fuel system. These filters effectively separate water from the fuel, preventing corrosion and damage to fuel injectors, pumps and other critical engine components. By keeping the fuel clean and water-free, these filters help ensure optimal combustion, improve engine efficiency, and reduce emissions. Carquest Premium Fuel/Water Separator Filters are designed to meet or exceed the performance requirements of the Original Equipment Manufacturer (OEM).

Product Features:
  • Designed to meet or exceed OE filter performance levels over the entire OE recommended service interval.
  • Made in USA
See More

Dorman – HD Solutions – Air Inlet Manifold Pressure Sensor (Part No.904-7033)

Air Inlet Manifold Pressure Sensor

from

$141.99
This manifold absolute pressure sensor is designed to match the function of an original sensor on specified vehicles, and to help accurately monitor manifold pressure when an original sensor has failed from heat or internal component damage.

Product Features:
  • Direct replacement – this manifold absolute pressure sensor is designed to match the fit and function of the original sensor on specified vehicles
  • Ideal solution – engineered to help accurately monitor manifold pressure when an original sensor has failed from heat or internal component damage
  • Durable construction – designed and manufactured to strict specifications for reliable performance
  • Trustworthy quality – backed by a team of product experts in the United States and more than a century of automotive experience
See More

Dorman – HD Solutions – Manifold Absolute Pressure Sensor (Part No.904-7107)

Manifold Absolute Pressure Sensor

from

$158.99
This manifold absolute pressure sensor is designed to match the function of an original sensor on specified vehicles, and to help accurately monitor manifold pressure when an original sensor has failed from heat or internal component damage.

Product Features:
  • Direct replacement – this manifold absolute pressure sensor is designed to match the fit and function of the original sensor on specified vehicles
  • Ideal solution – engineered to help accurately monitor manifold pressure when an original sensor has failed from heat or internal component damage
  • Durable construction – designed and manufactured to strict specifications for reliable performance
  • Trustworthy quality – backed by a team of product experts in the United States and more than a century of automotive experience
See More

Dorman – HD Solutions – Air Inlet Manifold Pressure Sensor (Part No.904-7037)

Air Inlet Manifold Pressure Sensor

from

$211.99
This manifold absolute pressure sensor is designed to match the function of an original sensor on specified vehicles, and to help accurately monitor manifold pressure when an original sensor has failed from heat or internal component damage.

Product Features:
  • Direct replacement – this manifold absolute pressure sensor is designed to match the fit and function of the original sensor on specified vehicles
  • Ideal solution – engineered to help accurately monitor manifold pressure when an original sensor has failed from heat or internal component damage
  • Durable construction – designed and manufactured to strict specifications for reliable performance
  • Trustworthy quality – backed by a team of product experts in the United States and more than a century of automotive experience
See More

Dorman – HD Solutions – Heavy Duty Exhaust Gas Recirculation Valve (Part No.904-5098)

Heavy Duty Exhaust Gas Recirculation Valve

from

$1202.99
This EGR valve is designed to match the fit and function of the original valve on specified vehicles. Made of quality materials, it is engineered for reliable performance and durability.

Product Features:
  • Direct replacement – this EGR valve is designed to match the fit and function of the original valve on specified vehicles
  • Ideal solution – this valve is engineered to withstand extreme heat and carbon buildup, and is a reliable replacement for a failed original EGR valve
  • Durable construction – made from quality components to ensure reliable performance and long service life
  • Quality assured – backed by a team of product engineers based in the United States
See More

Carquest Premium – Fuel/Water Separator: Quality Removal of Water and Contaminants from Fuel System (Part No.86422)

Fuel/Water Separator: Quality Removal of Water and Contaminants from Fuel System

from

$60.99
Carquest Premium Fuel/Water Separator Filters remove water and other impurities from the fuel before it reaches your engine fuel system. These filters effectively separate water from the fuel, preventing corrosion and damage to fuel injectors, pumps and other critical engine components. By keeping the fuel clean and water-free, these filters help ensure optimal combustion, improve engine efficiency, and reduce emissions. Carquest Premium Fuel/Water Separator Filters are designed to meet or exceed the performance requirements of the Original Equipment Manufacturer (OEM).

Product Features:
  • Designed to meet or exceed OE filter performance levels over the entire OE recommended service interval.
  • Contains Sensor Port Thread: M14 x 2.0; Standpipe
  • Includes Standpipe. Sensor Port Thread: M14 x 2.0
  • CAUTION: Furnished D-Ring must be installed on post for seal. NOT Interchangeable with 86604.
See More

Dorman – HD Solutions – Injector O-Ring Kit (Part No.904-8050)

Injector O-Ring Kit

from

$107.99
The components in this fuel injector O-ring kit are designed to match the fit of the original O-rings on specified vehicles. They are engineered to help ensure leak-free connections to the fuel injectors during service or when the rings are damaged.

Product Features:
  • Direct replacements – the components in this fuel injector O-ring kit are designed to match the fit of the original O-rings on specified vehicles
  • Ideal solution – engineered to help ensure leak-free connections to the fuel injectors during service or when the rings are damaged
  • Durable construction – designed and manufactured to strict specifications for reliable performance
  • Trustworthy quality – backed by a team of product experts in the United States and more than a century of automotive experience
See More

Dorman – HD Solutions – Injector O-Ring Kit (Part No.904-8053)

Injector O-Ring Kit

from

$97.99
The components in this fuel injector O-ring kit are designed to match the fit of the original O-rings on specified vehicles. They are engineered to help ensure leak-free connections to the fuel injectors during service or when the rings are damaged.

Product Features:
  • Direct replacements – the components in this fuel injector O-ring kit are designed to match the fit of the original O-rings on specified vehicles
  • Ideal solution – engineered to help ensure leak-free connections to the fuel injectors during service or when the rings are damaged
  • Durable construction – designed and manufactured to strict specifications for reliable performance
  • Trustworthy quality – backed by a team of product experts in the United States and more than a century of automotive experience
See More

Dorman – HD Solutions – Water In Fuel Sensor (Part No.904-7242)

Water In Fuel Sensor

from

$117.99
This replacement water-in-fuel (WiF) sensor matches the function and performance of the original equipment sensor to prevent water damaging a diesel fuel injector. Made of quality materials, it has undergone extensive testing to ensure durability.

Product Features:
  • Ideal replacement – this water-in-fuel (WiF) sensor matches the original equipment sensor’s function and performance
  • Durable construction – this sensor is made of durable materials to withstand exposure to diesel fuel
  • Cost-effective solution – offers original equipment quality at competitive price
  • Quality tested – this part has undergone vehicle try-on and bench testing to ensure a quality fit and long service life
See More

Dorman – HD Solutions – EGR Cooler V-Band Clamp (Part No.904-5154)

EGR Cooler V-Band Clamp

from

$65.99
This exhaust gas recirculation (EGR) cooler clamp is designed to match the fit of the original clamp on specified vehicles and is recommended for replacement during EGR cooler service. It is engineered from stainless steel for reliable service life.

Product Features:
  • Direct replacement – this exhaust gas recirculation (EGR) cooler clamp is designed to match the fit of the original clamp and is recommended for replacement during EGR cooler service
  • Ideal solution – engineered from stainless steel to withstand extreme heat and to resist corrosion
  • Durable construction – designed and manufactured to strict specifications for reliable performance
  • Trustworthy quality – backed by a team of product experts in the United States and more than a century of automotive experience
See More

Upgrade your 2006 Peterbilt 378 with Top-Quality Fuel and Emissions Systems

When it comes to maintaining or upgrading your 2006 Peterbilt 378, nothing is more important than using high-quality OEM or aftermarket parts that you can trust. Whether you’re repairing damage to your Peterbilt or enhancing its overall performance, Fuel and Emissions Systems are key to keeping your 378 functioning at its best. At Advance Auto Parts, we offer a wide selection of 8 Fuel and Emissions Systems for the 2006 Peterbilt 378, designed to meet your needs without breaking the bank. From Exhaust Gas Recirculation (EGR) Part replacements to Fuel Sensors upgrades, we’ve got you covered with parts that fit your vehicle perfectly and ensure long-lasting performance.

Affordable Prices and Wide Selection

Shopping for Fuel and Emissions Systems for any vehicle can be a hassle, especially if you’re on a budget. But with Advance Auto Parts, you can find high-quality Fuel and Emissions Systems for your 2006 Peterbilt 378 at great prices. Our Fuel and Emissions Systems inventory for this model ranges from just $45.99 to $1,202.99, with an average price of $192.37. Our 8 Fuel and Emissions Systems in stock come from 2 trusted brands, so you’re sure to find the right part for your 2006 Peterbilt 378 without overspending.

Explore Related Parts and More

While you’re here, don’t forget to check out other essential categories that go hand in hand with Fuel and Emissions System upgrades. Explore related part types like Batteries and Chargers, Fluids and Chemicals and more to make sure your 2006 Peterbilt 378 is always ready to roll. We’re committed to providing you with everything you need to keep your 378 in top shape, all in one place. Start shopping confidently below for your 2006 Peterbilt 378!

Best-Selling Exhaust Gas Recirculation (EGR) Parts for 2006 Peterbilt 378s

Enhance the driving experience in your Peterbilt with 2 quality Exhaust Gas Recirculation (EGR) Part components, starting at $65.99.

Dorman – HD Solutions – Heavy Duty Exhaust Gas Recirculation Valve (Part No.904-5098)

Heavy Duty Exhaust Gas Recirculation Valve

from

$1202.99
This EGR valve is designed to match the fit and function of the original valve on specified vehicles. Made of quality materials, it is engineered for reliable performance and durability.

Product Features:
  • Direct replacement – this EGR valve is designed to match the fit and function of the original valve on specified vehicles
  • Ideal solution – this valve is engineered to withstand extreme heat and carbon buildup, and is a reliable replacement for a failed original EGR valve
  • Durable construction – made from quality components to ensure reliable performance and long service life
  • Quality assured – backed by a team of product engineers based in the United States
See More

Dorman – HD Solutions – EGR Cooler V-Band Clamp (Part No.904-5154)

EGR Cooler V-Band Clamp

from

$65.99
This exhaust gas recirculation (EGR) cooler clamp is designed to match the fit of the original clamp on specified vehicles and is recommended for replacement during EGR cooler service. It is engineered from stainless steel for reliable service life.

Product Features:
  • Direct replacement – this exhaust gas recirculation (EGR) cooler clamp is designed to match the fit of the original clamp and is recommended for replacement during EGR cooler service
  • Ideal solution – engineered from stainless steel to withstand extreme heat and to resist corrosion
  • Durable construction – designed and manufactured to strict specifications for reliable performance
  • Trustworthy quality – backed by a team of product experts in the United States and more than a century of automotive experience
See More

Most Popular 2006 Peterbilt 378 Fuel Sensors

Customize your Peterbilt with 1 Fuel Sensors products like Water In Fuel Sensors, all priced under $117.99.

Dorman – HD Solutions – Water In Fuel Sensor (Part No.904-7242)

Water In Fuel Sensor

from

$117.99
This replacement water-in-fuel (WiF) sensor matches the function and performance of the original equipment sensor to prevent water damaging a diesel fuel injector. Made of quality materials, it has undergone extensive testing to ensure durability.

Product Features:
  • Ideal replacement – this water-in-fuel (WiF) sensor matches the original equipment sensor’s function and performance
  • Durable construction – this sensor is made of durable materials to withstand exposure to diesel fuel
  • Cost-effective solution – offers original equipment quality at competitive price
  • Quality tested – this part has undergone vehicle try-on and bench testing to ensure a quality fit and long service life
See More

Top Picks for 2006 Peterbilt 378 Fuel Injectors

Upgrade Peterbilt 378s with top-quality Fuel Injectors parts, including 1 OEM and aftermarket selections for your 2006 model.

Dorman – HD Solutions – Injector O-Ring Kit (Part No.904-8053)

Injector O-Ring Kit

from

$97.99
The components in this fuel injector O-ring kit are designed to match the fit of the original O-rings on specified vehicles. They are engineered to help ensure leak-free connections to the fuel injectors during service or when the rings are damaged.

Product Features:
  • Direct replacements – the components in this fuel injector O-ring kit are designed to match the fit of the original O-rings on specified vehicles
  • Ideal solution – engineered to help ensure leak-free connections to the fuel injectors during service or when the rings are damaged
  • Durable construction – designed and manufactured to strict specifications for reliable performance
  • Trustworthy quality – backed by a team of product experts in the United States and more than a century of automotive experience
See More

In-Demand Fuel Pumps for 2006 Peterbilt 378s

Select from 2 premium Fuel Pumps parts for your 2006 Peterbilt 378, with prices ranging from $45.99 to $60.99.

Carquest Premium – Fuel/Water Separator: Quality Removal of Water and Contaminants from Fuel System (Part No.86651XE)

Fuel/Water Separator: Quality Removal of Water and Contaminants from Fuel System

from

$45.99
Carquest Premium Fuel/Water Separator Filters remove water and other impurities from the fuel before it reaches your engine fuel system. These filters effectively separate water from the fuel, preventing corrosion and damage to fuel injectors, pumps and other critical engine components. By keeping the fuel clean and water-free, these filters help ensure optimal combustion, improve engine efficiency, and reduce emissions. Carquest Premium Fuel/Water Separator Filters are designed to meet or exceed the performance requirements of the Original Equipment Manufacturer (OEM).

Product Features:
  • Designed to meet or exceed OE filter performance levels over the entire OE recommended service interval.
  • Made in USA
See More

Carquest Premium – Fuel/Water Separator: Quality Removal of Water and Contaminants from Fuel System (Part No.86422)

Fuel/Water Separator: Quality Removal of Water and Contaminants from Fuel System

from

$60.99
Carquest Premium Fuel/Water Separator Filters remove water and other impurities from the fuel before it reaches your engine fuel system. These filters effectively separate water from the fuel, preventing corrosion and damage to fuel injectors, pumps and other critical engine components. By keeping the fuel clean and water-free, these filters help ensure optimal combustion, improve engine efficiency, and reduce emissions. Carquest Premium Fuel/Water Separator Filters are designed to meet or exceed the performance requirements of the Original Equipment Manufacturer (OEM).

Product Features:
  • Designed to meet or exceed OE filter performance levels over the entire OE recommended service interval.
  • Contains Sensor Port Thread: M14 x 2.0; Standpipe
  • Includes Standpipe. Sensor Port Thread: M14 x 2.0
  • CAUTION: Furnished D-Ring must be installed on post for seal. NOT Interchangeable with 86604.
See More

Most Sold 2006 Peterbilt 378 Air Flow Sensors

Explore our best-selling Peterbilt parts for the 2006 378 among 2 OEM and aftermarket options starting from $158.99.

Dorman – HD Solutions – Air Inlet Manifold Pressure Sensor (Part No.904-7037)

Air Inlet Manifold Pressure Sensor

from

$211.99
This manifold absolute pressure sensor is designed to match the function of an original sensor on specified vehicles, and to help accurately monitor manifold pressure when an original sensor has failed from heat or internal component damage.

Product Features:
  • Direct replacement – this manifold absolute pressure sensor is designed to match the fit and function of the original sensor on specified vehicles
  • Ideal solution – engineered to help accurately monitor manifold pressure when an original sensor has failed from heat or internal component damage
  • Durable construction – designed and manufactured to strict specifications for reliable performance
  • Trustworthy quality – backed by a team of product experts in the United States and more than a century of automotive experience
See More

Dorman – HD Solutions – Manifold Absolute Pressure Sensor (Part No.904-7107)

Manifold Absolute Pressure Sensor

from

$158.99
This manifold absolute pressure sensor is designed to match the function of an original sensor on specified vehicles, and to help accurately monitor manifold pressure when an original sensor has failed from heat or internal component damage.

Product Features:
  • Direct replacement – this manifold absolute pressure sensor is designed to match the fit and function of the original sensor on specified vehicles
  • Ideal solution – engineered to help accurately monitor manifold pressure when an original sensor has failed from heat or internal component damage
  • Durable construction – designed and manufactured to strict specifications for reliable performance
  • Trustworthy quality – backed by a team of product experts in the United States and more than a century of automotive experience
See More

FAQs for 2006 Peterbilt 378 Fuel and Emissions Systems

Which Fuel and Emissions Systems are best-sellers for 2006 Peterbilt 378s?

Out of 8 Fuel and Emissions Systems that fit 2006 Peterbilt 378s, the following parts are the top sellers:

What’s the price range for 2006 Peterbilt 378 Fuel and Emissions Systems?

Fuel and Emissions System prices for the 2006 Peterbilt 378 start at $45.99 and go up to $1,202.99 for the most premium parts.

What’s the average price of a Fuel and Emissions System for a 2006 Peterbilt 378?

The average price for Fuel and Emissions Systems for the 2006 Peterbilt 378 is $192.37. Keep in mind the variety of part types within our Fuel and Emissions System category so you are likely to find a wide range of prices across a variety of parts and components.

Does Advance Auto Parts sell Fuel and Emissions Systems for other Peterbilt 378 model years?

Yes, we currently carry Fuel and Emissions Systems for 18 model years of Peterbilt 378s between 1988 and 2007. Fuel and Emissions Systems are bought most frequently for the following model years: 2007, 2005, 2004, 2003, 2002, 2001, 2000, 1999, and 1998.

What are the cheapest Fuel and Emissions Systems for my 2006 Peterbilt 378?

The cheapest 2006 Peterbilt 378 Fuel and Emissions Systems we carry in stock are:

What types of Fuel and Emissions Systems do you sell for my 2006 Peterbilt 378?

As of 11/2/25, these are some of the most in-demand types of Fuel and Emissions Systems for a 2006 Peterbilt 378:

Can I get help with 2006 Peterbilt 378 Fuel and Emissions System orders?

Contact our customer support team, by chat or phone, through the help desk page, where you can find instant answers about Peterbilt Fuel and Emissions Systems and more.

What is your return policy for Peterbilt 378 Fuel and Emissions Systems?

Advance Auto Parts keeps returns simple. For new Peterbilt 378 Fuel and Emissions Systems and accessories, your online orders can be returned, in their original condition, within 45 days. For requirements, see the returns page.