2006 Isuzu I-280 Engine Cooling Parts

Keep Your 2006 Isuzu I-280 in Top Shape with Quality Engine Cooling Parts

Whether you’re repairing or upgrading your Engine Cooling Part, using high-quality parts is key to keeping your 2006 Isuzu I-280 looking sharp and performing at its best. At Advance Auto Parts we carry a wide selection of dependable options, including Thermostat and Water Outlet Assemblies, Radiators, and Thermostat and Water Outlet Gaskets. Whether you’re replacing a damaged part or enhancing your truck’s style and protection, you’ll find exactly what you need to get the job done right.

Top-Rated Engine Cooling Parts from Trusted Brands

Looking for a reliable Engine Cooling Part? We’ve got you covered with options from brands you know and trust like Carquest Premium, FELPRO, and Imperial. For example, Carquest Premium Engine Cooling Parts start at just $15.99 with an average 4.4 star rating. FELPRO and Imperial offer similar pricing and quality, backed by strong customer feedback. With over 421 reviews and a solid 4 star average, you can shop with confidence knowing other Isuzu I-280 owners approve.

Competitive Prices and Extensive Inventory

The average price for a 2006 Isuzu I-280 Engine Cooling Part at Advance Auto Parts is around $67.05, with a range that starts at $4.79 and goes up to $288.99. With 29 options in stock from 12 trusted brands, finding the right fit is easy. Popular picks like Adjustable Thermostatic Fan Control, Electric Fan, 12" Diameter, and Engine Coolant Thermostat Gasket start at just $4.79 and offer a great balance of form and function.

Explore Related Parts

While you’re upgrading or replacing your Engine Cooling Part, don’t forget to check out other key components like Blend Doors and Blower Motor and Related Products. At Advance Auto Parts, we’re here to help you keep your 2006 Isuzu I-280 in peak condition, inside and out.

Essential 2006 Isuzu I-280 Engine Cooling Parts

GM Genuine Parts – Engine Coolant Thermostat and Housing Assembly (Part No.15-11073)

Engine Coolant Thermostat and Housing Assembly

from

$112.99
ACDelco GM Original Equipment Engine Coolant Thermostat Housing Assemblies are designed, engineered, and tested to rigorous standards, and are backed by General Motors. ACDelco GM Original Equipment parts are the true OE parts installed during the production of or validated by General Motors for GM vehicles. Some ACDelco GM Original Equipment parts may have formerly appeared as GM Genuine Parts (OE) or ACDelco Professional.

Product Features:
  • Some ACDelco GM Original Equipment parts may have formerly appeared as GM Genuine Parts (OE) or ACDelco Professional
  • ACDelco GM Original Equipment parts are designed, engineered and tested to rigorous standards, and are backed by General Motors.
  • GM Engineers design and validate OE parts specifically for your Chevrolet, Buick, GMC, or Cadillac vehicle
  • GM regularly updates production and service part designs to integrate new materials and technologies
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Carquest Premium – Universal Fan Clutch – 7" Thermal Heavy Duty (Part No.215138)

Universal Fan Clutch - 7" Thermal Heavy Duty

from

$97.99
Product Features:
  • Designed, tested, and built by application
  • OE performance, fit, and appearance
  • Precision machined
  • Out of box installation
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Dorman – Engine Coolant Water Outlet (Part No.902-116)

Engine Coolant Water Outlet

from

$21.99
This replacement engine coolant water outlet is engineered to match the fit and durability of the stock engine coolant water outlet on specified vehicles. It is designed to withstand extreme temperature changes to extend service life.

Product Features:
  • Ideal replacement – this engine coolant water outlet directly replaces the original water outlet on specified vehicle years, makes and models
  • Durable construction – this part is specifically designed to withstand extreme temperature changes and resist cracking and leaking
  • Cost-effective and reliable – offers original manufacturer quality at lower cost than getting replacement at dealer
  • Industry-leading design – professionally engineered by the aftermarket leader in replacement water outlets
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Carquest Premium – Coolant Housing/Water Outlet (Part No.85096)

Coolant Housing/Water Outlet

from

$39.99
We are proud to offer this Carquest product line: Carquest Water Outlets. Our products are engineered and tested to provide years of trouble free operation and designed to be hassle free OE replacement part that meets and/or exceeds OE standards. Backed by over 50 years of mobile temperature control experience, fix it once and fix it right with CARQUST Water Outlets and Thermostat Housings.

Product Features:
  • Meets and/or exceeds OEM standard
  • Direct-fit replacement for ease of installation
  • 100% leak tested
  • Meets and/or exceeds OEM standard
  • 100% leak tested
  • Direct-fit replacement for ease of installation
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Imperial – Thermostatic Fan Control – Adjustable (Part No.226208)

Thermostatic Fan Control - Adjustable

from

$69.99
Our products are engineered and tested to provide years of trouble free operation. Backed by over 50 years of mobile a/c experience, fix it once and fix it right with Imperial.

Product Features:
  • Adjustable thermostatic fan control
  • 160 Deg. F – 210 Deg. F thread-in probe
  • For use with Imperial electric fans
  • Thread-in probe for installation in water jacket or radiator
  • Contains gaskets, O-rings, or seals to properly replace the product
  • Brass construction for accurate temperature sensing
  • Zinc coated terminal to resist corrosion
  • Vehicle specific applications
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Imperial – Thermostatic Fan Control – Preset (Part No.226206)

Thermostatic Fan Control - Preset

from

$46.99
Our products are engineered and tested to provide years of trouble free operation. Backed by over 50 years of mobile a/c experience, fix it once and fix it right with Imperial.

Product Features:
  • Preset thermostatic fan control
  • 185 Deg. F preset
  • For use with Imperial electric fans
  • Probe installs into radiator fins
  • Contains gaskets, O-rings, or seals to properly replace the product
  • Brass construction for accurate temperature sensing
  • Zinc coated terminal to resist corrosion
  • Vehicle specific applications
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Carquest Premium – Radiator Cap Tester Adapter (Part No.12033)

Radiator Cap Tester Adapter

from

$95.99
Tester adapter for the MT-300 cooling system pressure testers. Professional grade test equipment to ensure an automotive cooling system is operating at the correct pressure. Made from high quality materials to ensure durability. Designed to test automotive coolant caps.

Product Features:
  • Machined metal construction
  • Works with MT-300 pressure tester
  • Tests coolant caps
  • Professional quality
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ACDelco – Water Pump Kit (Part No.252-822)

Water Pump Kit

from

$133.99
An ACDelco Professional, premium aftermarket Engine Water Pump circulates coolant through your vehicle’s radiator and engine system to help maintain proper engine temperature and performance. The gaskets, seals, and O-rings packaged with this Professional, premium aftermarket water pump help guarantee that all necessary parts are available for trouble-free installation. ACDelco Professional Water Pumps are a high quality replacement for many vehicles on the road today. This premium aftermarket replacement engine water pump is manufactured to meet your expectations for fit, form, and function.

Product Features:
  • All Makes water pumps fit GM vehicles as well as a wide range of non-GM vehicles
  • Thoroughly tested for reliable, leak-free performance
  • Coated seals support seal longevity and durability
  • Heat-treated shaft assemblies provide superior strength and durability over non-treated assemblies
  • High-quality bearings are permanently sealed and lubricated for greater durability and long life
  • Come with premium, high-quality replacement components needed for trouble-free and accurate installation
  • Uniform wall sections and smooth coolant-flow cavities for efficient operation
  • Cast-iron or aluminum design, depending on vehicle application
See More

Carquest Premium – Engine Water Pump: New, Gasket/Seals Included (Part No.T1231)

Engine Water Pump: New, Gasket/Seals Included

from

$71.99
Carquest Premium drive motor inverter cooler water pumps are 100% new, high-quality parts that meet or exceed original equipment (O.E.) specifications. All components, including the housing, impeller, controller, gaskets, and seals are designed for long-lasting service life. These electric water pumps are supplied with the gaskets or seals necessary for installation. Our Carquest Premium auxiliary water pumps undergo stringent testing to ensure superior performance that we stand behind with an industry-leading warranty.

Product Features:
  • Built to meet or exceed OE fit, form and function
  • All components necessary for installation are supplied with pump
  • 100% tested for reliable performance
  • Follow all enclosed instructions to maximize pump life and validate warranty
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GM Genuine Parts – Engine Coolant Temperature Sensor (Part No.213-4233)

Engine Coolant Temperature Sensor

from

$39.99
ACDelco GM Original Equipment Engine Coolant Temperature Sensors monitor engine temperature, and are GM-recommended replacements for your vehicle’s original components. The engine temperature signal is used by the engine control module to adjust the air/fuel mixture and ignition timing. These original equipment engine coolant temperature sensors have been manufactured to fit your GM vehicle, providing the same performance, durability, and service life you expect from General Motors.

Product Features:
  • Helps keep engine running at proper temperature
  • Alerts vehicle operator of high engine temperature conditions
  • GM-recommended replacement part for your GM vehicle’s original factory component
  • Offering the quality, reliability, and durability of GM OE
  • Manufactured to GM OE specification for fit, form, and function
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Carquest Premium – Coolant Temperature Sensor (Part No.WTC1033)

Coolant Temperature Sensor

from

$39.99
Carquest Premium coolant temperature sensors and switches are designed to perform in harsh engine environments and meet or exceed original equipment (O.E.) specifications. Built by manufacturers that meet IATF 16949 certified framework, an internationally recognized proof of quality in the automotive industry, Carquest Premium coolant temperature sensors and switches undergo extensive validation testing to ensure long-lasting performance and reliability. Carquest Premium coolant temperature sensors and switches are part of our Carquest Vehicle Solutions, which is a full line of engine management and electronics products that help control ignition, fuel delivery and emission systems. Carquest Vehicle Solutions are OE-quality parts designed, engineered and tested by world-class manufacturers to ensure a reliable and long-lasting repair.

Product Features:
  • Designed to meet or exceed OE specifications for fit, form and function
  • 100% factory resistance calibrated to ensure precision tolerances, resulting in extremely accurate temperature for optimal performance
  • OE precision matched thermistor ensuring sensors match OE output resistances across all temperature positions
  • O-rings, seals or thread sealant are included if required
  • Weather-tight connectors prevent leaks and corrosion for longer life
  • Extensive design validation testing and 100% end-of-line tested
  • Carquest Vehicle Solutions Technical Support available from ASE certified technicians: 1-866-687-5413
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Imperial – Electric Fan, 14" Diameter (Part No.226114)

Electric Fan, 14" Diameter

from

$99.99
Our products are engineered and tested to provide years of trouble free operation. Backed by over 50 years of mobile a/c experience, fix it once and fix it right with Imperial.

Product Features:
  • Motors built and tested to quality specifications
  • 14 in. universal fit reversible fan
  • 1250 CFM
  • UNIVERSAL fan, NOT a direct OE replacement. Measure core and verify space.
  • Motors built and tested to quality specifications
  • 14 in. universal fit reversible fan
  • 1250 CFM
  • UNIVERSAL fan, NOT a direct OE replacement. Measure core and verify space.
See More

Imperial – Electric Fan, 12" Diameter (Part No.226112)

Electric Fan, 12" Diameter

from

$108.99
Our products are engineered and tested to provide years of trouble free operation. Backed by over 50 years of mobile a/c experience, fix it once and fix it right with Imperial.

Product Features:
  • Rapid-Cool Thin-Line electric fans
  • 12″ Diameter
  • 800 CFM
  • Use as a pusher or puller fan
  • Motors built and tested to quality specifications
  • 12 in. universal fit reversible fan
  • 800 CFM
  • UNIVERSAL fan, NOT a direct OE replacement. Measure core and verify space.
See More

Motorad – Integrated Thermostat Housing: With Seal, 187 Degrees (Part No.538-187)

Integrated Thermostat Housing: With Seal, 187 Degrees

from

$62.99
Manufactured with OEM quality materials and safety standards by an OE Supplier. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant. Offset design, air relief valve, and OEM style seals included where applicable.

Product Features:
  • High grade stainless steel and copper construction
  • Meets or exceeds OEM standards
  • Consistent and precise response to cooling system needs
  • Original equipment design for worry-free direct fit replacement
  • 100% tested and calibrated
See More

MAHLE Original – Water Pump Gasket (Part No.K31757)

Water Pump Gasket

from

$7.99
MAHLE® gaskets provide world class sealing products trusted by OEMs & Technicians around the globe.

Product Features:
  • All MAHLE gaskets meet or exceed the original equipment specifications providing the finest sealing products available
  • MAHLE gaskets utilizes OE equivalent or better materials in all our gaskets
  • MAHLE gaskets is the leader in Domestic, Asian and European applications
  • The contents of MAHLE gaskets are packaged in shrink wrapped tray, giving you the added security of knowing that you have the right parts, prior to opening the package
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Felpro – Engine Water Pump Gasket (Part No.35704)

Engine Water Pump Gasket

from

$5.79
Fel-Pro gaskets offer 100% vehicle sealing with application-specific materials to give you sealing solutions with the performance and durability professionals trust.

Product Features:
  • Meets or exceeds all original equipment specifications
  • Application specific design
  • Manufactured for the sealing repair environment
  • Validated for fit, form, and function
  • Quality that you can trust
See More

Carquest Premium – Radiator Cap: 15 PSI (Part No.10248)

Radiator Cap: 15 PSI

from

$15.99
Crafted to meet the exact specifications set by Original Equipment Manufacturers (OEM), these products are engineered for effortless installation and removal. Constructed from premium-grade components, incorporating proper relief and vacuum valves, they ensure optimal performance even in the most demanding automotive cooling systems. Rigorously quality-tested, these components provide exceptional, out-of-the-box performance and superior durability to meet or exceed the highest standards of today’s vehicles.

Product Features:
  • Maintains proper cooling system pressure
  • Easy installation and removal
  • 100% tested to ensure proper pressure and longevity
  • Meets all OEM specifications
See More

Carquest Premium – Radiator: With Transmission Oil Cooler (Part No.433859)

Radiator: With Transmission Oil Cooler

from

$288.99
Carquest Premium radiators are designed and engineered for maximum performance, using the highest-grade materials to ensure all radiators meet or exceed original equipment (O.E.) fit, form and function. Carquest Premium radiators are built by manufacturers that meet IATF 16949 certified framework, an internationally recognized proof of quality in the automotive industry. Most modern vehicles use radiators with plastic tanks and our parts are engineered with integrated ribbing to prevent damage during thermal cycling. Carquest Premium radiators are also 100% tested to ensure a durable, leak-free cooling system repair.

Product Features:
  • Thermal tested under real-life temperature simulations
  • High tensile strength aluminum for maximum crimp strength
  • Plastic tanks are engineered with integrated ribbing for added strength to withstand cracks, bowing and distortion during thermal cycles
  • Thermal expansion slots extend core life and reduce failure rates by allowing improved core expansion and contraction during systematic heat cycles
  • Oil cooler designs meet or exceed OE standards, keeping the vehicle¿s engine and transmission performing at optimal conditions
  • OEM grade, premium fittings for transmission or engine oil coolers (where applicable)
See More

KAI – Radiator (Part No.RAD2707)

Radiator

from

$163.99
New Platinum Pro Radiator, 2.8/2.9/3.5/3.7 Liter Engines, Automatic Or Manual Transmission

Product Features:
  • 2.8/2.9/3.5/3.7 Liter Engines, Automatic Or Manual Transmission, Made Of Plastic and Aluminum
  • Meets All Federal Motor Safety Standards
  • No Drilling Needed For Installation
  • No Modifications Needed For Installation
  • Direct Fit Replacement For Your Vehicle
  • Same Form Fit And Function As OE
  • Radiator Cap Not Included
  • Check Out The Large Selection Of Parts Available For Your Vehicle
See More

Victor Reinz – Engine Coolant Thermostat Housing Gasket (Part No.71-14094-00)

Engine Coolant Thermostat Housing Gasket

from

$13.99
Product Features:
  • Choosing Victor Reinz assures getting OE quality parts in gaskets sets that have the coverage, contents, packaging and electronic cataloging to best meet the needs of the aftermarket.
  • Application specific design provides an exceptional fit.
  • Validated for fit, form, and function.
  • Meets or exceeds original equipment specifications.
See More

Felpro – Engine Coolant Thermostat Housing Gasket (Part No.36009)

Engine Coolant Thermostat Housing Gasket

from

$6.99
Fel-Pro gaskets are specifically designed for the repair environment to deliver a reliable seal on even the most troublesome applications. Designed for imperfect sealing surfaces and manufactured with proprietary materials, you can count on Fel-Pro for innovative sealing solutions for the real-world repair environment.

Product Features:
  • Meets or exceeds all original equipment specifications
  • Application specific design
  • Manufactured for the sealing repair environment
  • Validated for fit, form, and function
  • Quality that you can trust
See More

Felpro – Engine Coolant Thermostat Gasket (Part No.35632)

Engine Coolant Thermostat Gasket

from

$4.79
Fel-Pro gaskets offer 100% vehicle sealing with application-specific materials to give you sealing solutions with the performance and durability professionals trust.

Product Features:
  • Meets or exceeds all original equipment specifications
  • Application specific design to ensure a perfect fit
  • Engineered and manufactured specifically for the repair environment
  • Unsurpassed quality you can trust
  • Validated for fit, form, and function
See More

US MOTOR WORKS – Water Pump with Fan Clutch (Part No.MCK1048)

Water Pump with Fan Clutch

from

$97.99
US Motor Works Professional Series Water Pump with Fan Clutch are designed to replace the mechanical components of a cooling system. A proper water pump replacement should include a new fan clutch as the two are connected to the same shaft and work together to move the air and cooling fluid. Replacing one without the other can damage the new part and cause repeat work or engine trouble. This matched set will allow your vehicle continued operation in the demanding environment of today’s engine. All components are brand new and QA inspected for perfect fit and function. Restore your cooling power by installing a US Motor Works Professional Series Water Pump with Fan Clutch.

Product Features:
  • Fan clutch mounts to the water pump and should be replaced at the same time.
  • Matched set for proper water pump or fan clutch replacement
  • Includes mounting hardware, gaskets and accessories as required.
  • Complete mechanical cooling parts replacement
  • Factory tested and 100% new product
  • Meets or exceeds OEM quality
See More

Most Popular Thermostat and Water Outlet Assembly for 2006 Isuzu I-280s

Enhance your 2006 Isuzu I-280 with this popular Thermostat and Water Outlet Assembly we have in stock, for $62.99.

Motorad – Integrated Thermostat Housing: With Seal, 187 Degrees (Part No.538-187)

Integrated Thermostat Housing: With Seal, 187 Degrees

from

$62.99
Manufactured with OEM quality materials and safety standards by an OE Supplier. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant. Offset design, air relief valve, and OEM style seals included where applicable.

Product Features:
  • High grade stainless steel and copper construction
  • Meets or exceeds OEM standards
  • Consistent and precise response to cooling system needs
  • Original equipment design for worry-free direct fit replacement
  • 100% tested and calibrated
See More

Best-Selling 2006 Isuzu I-280 Radiators

Upgrade your I-280 with one of our 2 best-selling Radiators, earning an average 3.5 stars rating across 5 reviews.

Carquest Premium – Radiator: With Transmission Oil Cooler (Part No.433859)

Radiator: With Transmission Oil Cooler

from

$288.99
Carquest Premium radiators are designed and engineered for maximum performance, using the highest-grade materials to ensure all radiators meet or exceed original equipment (O.E.) fit, form and function. Carquest Premium radiators are built by manufacturers that meet IATF 16949 certified framework, an internationally recognized proof of quality in the automotive industry. Most modern vehicles use radiators with plastic tanks and our parts are engineered with integrated ribbing to prevent damage during thermal cycling. Carquest Premium radiators are also 100% tested to ensure a durable, leak-free cooling system repair.

Product Features:
  • Thermal tested under real-life temperature simulations
  • High tensile strength aluminum for maximum crimp strength
  • Plastic tanks are engineered with integrated ribbing for added strength to withstand cracks, bowing and distortion during thermal cycles
  • Thermal expansion slots extend core life and reduce failure rates by allowing improved core expansion and contraction during systematic heat cycles
  • Oil cooler designs meet or exceed OE standards, keeping the vehicle¿s engine and transmission performing at optimal conditions
  • OEM grade, premium fittings for transmission or engine oil coolers (where applicable)
See More

KAI – Radiator (Part No.RAD2707)

Radiator

from

$163.99
New Platinum Pro Radiator, 2.8/2.9/3.5/3.7 Liter Engines, Automatic Or Manual Transmission

Product Features:
  • 2.8/2.9/3.5/3.7 Liter Engines, Automatic Or Manual Transmission, Made Of Plastic and Aluminum
  • Meets All Federal Motor Safety Standards
  • No Drilling Needed For Installation
  • No Modifications Needed For Installation
  • Direct Fit Replacement For Your Vehicle
  • Same Form Fit And Function As OE
  • Radiator Cap Not Included
  • Check Out The Large Selection Of Parts Available For Your Vehicle
See More

Top-Quality Thermostat and Water Outlet Gaskets for 2006 Isuzu I-280s

Choose a high-quality OEM or aftermarket Thermostat and Water Outlet Gasket for Isuzu I-280s and enjoy top-notch performance from $4.79.

Felpro – Engine Coolant Thermostat Gasket (Part No.35632)

Engine Coolant Thermostat Gasket

from

$4.79
Fel-Pro gaskets offer 100% vehicle sealing with application-specific materials to give you sealing solutions with the performance and durability professionals trust.

Product Features:
  • Meets or exceeds all original equipment specifications
  • Application specific design to ensure a perfect fit
  • Engineered and manufactured specifically for the repair environment
  • Unsurpassed quality you can trust
  • Validated for fit, form, and function
See More

Felpro – Engine Coolant Thermostat Housing Gasket (Part No.36009)

Engine Coolant Thermostat Housing Gasket

from

$6.99
Fel-Pro gaskets are specifically designed for the repair environment to deliver a reliable seal on even the most troublesome applications. Designed for imperfect sealing surfaces and manufactured with proprietary materials, you can count on Fel-Pro for innovative sealing solutions for the real-world repair environment.

Product Features:
  • Meets or exceeds all original equipment specifications
  • Application specific design
  • Manufactured for the sealing repair environment
  • Validated for fit, form, and function
  • Quality that you can trust
See More

Our Top Pick for a 2006 Isuzu I-280 Coolant Reservoir Cap

Invest in a durable Coolant Reservoir Cap for your 2006 Isuzu, knowing you’re getting trusted brands and expert craftsmanship.

Carquest Premium – Radiator Cap: 15 PSI (Part No.10248)

Radiator Cap: 15 PSI

from

$15.99
Crafted to meet the exact specifications set by Original Equipment Manufacturers (OEM), these products are engineered for effortless installation and removal. Constructed from premium-grade components, incorporating proper relief and vacuum valves, they ensure optimal performance even in the most demanding automotive cooling systems. Rigorously quality-tested, these components provide exceptional, out-of-the-box performance and superior durability to meet or exceed the highest standards of today’s vehicles.

Product Features:
  • Maintains proper cooling system pressure
  • Easy installation and removal
  • 100% tested to ensure proper pressure and longevity
  • Meets all OEM specifications
See More

Top-Rated Water Pumps for 2006 Isuzu I-280s

Make a smart move for your 2006 Isuzu I-280 with products all priced from $71.99 to $133.99.

Carquest Premium – Engine Water Pump: New, Gasket/Seals Included (Part No.T1231)

Engine Water Pump: New, Gasket/Seals Included

from

$71.99
Carquest Premium drive motor inverter cooler water pumps are 100% new, high-quality parts that meet or exceed original equipment (O.E.) specifications. All components, including the housing, impeller, controller, gaskets, and seals are designed for long-lasting service life. These electric water pumps are supplied with the gaskets or seals necessary for installation. Our Carquest Premium auxiliary water pumps undergo stringent testing to ensure superior performance that we stand behind with an industry-leading warranty.

Product Features:
  • Built to meet or exceed OE fit, form and function
  • All components necessary for installation are supplied with pump
  • 100% tested for reliable performance
  • Follow all enclosed instructions to maximize pump life and validate warranty
See More

ACDelco – Water Pump Kit (Part No.252-822)

Water Pump Kit

from

$133.99
An ACDelco Professional, premium aftermarket Engine Water Pump circulates coolant through your vehicle’s radiator and engine system to help maintain proper engine temperature and performance. The gaskets, seals, and O-rings packaged with this Professional, premium aftermarket water pump help guarantee that all necessary parts are available for trouble-free installation. ACDelco Professional Water Pumps are a high quality replacement for many vehicles on the road today. This premium aftermarket replacement engine water pump is manufactured to meet your expectations for fit, form, and function.

Product Features:
  • All Makes water pumps fit GM vehicles as well as a wide range of non-GM vehicles
  • Thoroughly tested for reliable, leak-free performance
  • Coated seals support seal longevity and durability
  • Heat-treated shaft assemblies provide superior strength and durability over non-treated assemblies
  • High-quality bearings are permanently sealed and lubricated for greater durability and long life
  • Come with premium, high-quality replacement components needed for trouble-free and accurate installation
  • Uniform wall sections and smooth coolant-flow cavities for efficient operation
  • Cast-iron or aluminum design, depending on vehicle application
See More

Top-Rated Engine Cooling Part Brands For Your 2006 Isuzu I-280

When it comes to finding the perfect Engine Cooling Part for your 2006 Isuzu I-280, Advance Auto Parts has you covered with a wide selection of high-quality OEM and aftermarket options from 12 trusted brands. We carry the most popular Engine Cooling Part brands including FELPRO, Carquest Premium, and Imperial, and more, all known for their exceptional customer ratings (average brand rating of 4.6 stars) and competitive prices, as low as $4.79. Purchasing a Engine Cooling Part from us here at Advance Auto Parts is a smart move for both you and your 2006 Isuzu I-280, providing peace of mind with parts that meet or exceed OEM standards.

Popular FELPRO 2006 Isuzu I-280 Engine Cooling Parts

If you’re looking for a top-quality Engine Cooling Part for your 2006 Isuzu I-280, Advance Auto Parts has exactly what you need with our selection of FELPRO Engine Cooling Parts. We have 2 FELPRO Engine Cooling Parts in stock for this fitment, all known for their durability and precision fit. With prices starting at just $4.79 and an average cost of $5.29, you’ll find the perfect Engine Cooling Part for your needs and budget. FELPRO Engine Cooling Parts for the 2006 Isuzu I-280 come highly rated, with over 31 customer reviews and an impressive average rating of 4.6 stars. Choosing a FELPRO Engine Cooling Part from Advance Auto Parts is a smart move to ensure quality and value for your vehicle.
Engine Coolant Thermostat Gasket
from $4.79
(20)
Engine Coolant Thermostat Gasket
“No leaks!”
Engine Water Pump Gasket
from $5.79
(11)
Engine Water Pump Gasket
“Very good”

Top-Quality Carquest Premium 2006 Isuzu I-280 Engine Cooling Parts

For those in search of a high-quality Engine Cooling Part for their 2006 Isuzu I-280, Advance Auto Parts offers a great selection of Carquest Premium Engine Cooling Parts. With 2 Carquest Premium Engine Cooling Parts in stock, you can trust you’re getting top-tier parts designed for durability and a perfect fit. Prices for these Engine Cooling Parts start at just $15.99, with an average price of $43.99, giving you a range of options to suit your budget. Backed by over 237 customer ratings and an average rating of 4.4 stars, Carquest Premium Engine Cooling Parts provide both reliability and excellent performance. Choosing a Carquest Premium Engine Cooling Part from Advance Auto Parts is a smart investment in your vehicle’s performance and longevity.
Radiator Cap: 15 PSI
from $15.99
(59)
Radiator Cap: 15 PSI
“Just what I needed”
Engine Water Pump: New, Gasket/Seals Included
from $71.99
(178)
Engine Water Pump: New, Gasket/Seals Included
“Great service & fast , thank you”

FAQs for 2006 Isuzu I-280 Engine Cooling Parts

What are the best-selling Engine Cooling Parts for 2006 Isuzu I-280s?

Out of 29 Engine Cooling Parts that fit 2006 Isuzu I-280s, the following parts are the top sellers:

What’s the price range for 2006 Isuzu I-280 Engine Cooling Parts?

The prices of Engine Cooling Parts for the 2006 Isuzu I-280 range from $4.79 up to $288.99 for the most premium parts.

What is the average price of an Engine Cooling Part for a 2006 Isuzu I-280?

The average price for Engine Cooling Parts for the 2006 Isuzu I-280 is $67.05. Keep in mind the variety of part types within our Engine Cooling Part category, where you are likely to find a wide range of prices across a variety of parts and components.

What are the cheapest Engine Cooling Parts for my 2006 Isuzu I-280?

The cheapest 2006 Isuzu I-280 Engine Cooling Parts we carry are:

Does Advance Auto Parts sell Engine Cooling Parts for any other 2006 Isuzu models?

Yes. We stock Engine Cooling Parts for 11 other popular 2006 Isuzu models. Some of the most popular are 2006 Ascender Engine Cooling Parts, 2006 NPR Engine Cooling Parts, 2006 I-350 Engine Cooling Parts, 2006 NPR-HD Engine Cooling Parts, and 2006 FTR Engine Cooling Parts.

What are the top-rated Engine Cooling Parts that fit the 2006 Isuzu I-280?

Based on 421 reviews by customers, our 2006 Isuzu I-280 Engine Cooling Parts have an average customer rating of 4 stars. These are the highest-rated categories of Engine Cooling Parts for the 2006 Isuzu I-280 and their top-rated products:

What types of Engine Cooling Parts do you sell for my 2006 Isuzu I-280?

As of 11/2/25, these are some of the most in-demand types of Engine Cooling Parts for a 2006 Isuzu I-280:

Can I get help with 2006 Isuzu I-280 Engine Cooling Part orders?

Contact our customer support team by chat or phone, through the help desk page, where you can find instant answers about Isuzu Engine Cooling Parts and more.

What is your return policy for Isuzu I-280 Engine Cooling Parts?

Advance Auto Parts keeps returns simple. For new Isuzu I-280 Engine Cooling Parts and accessories, your online orders can be returned, in their original condition, within 45 days. For requirements, see the returns page.