2000 Mercedes-Benz S500 Engine Cooling Parts

Please Select your Vehicle to See Exact Fit Parts

Keep Your 2000 Mercedes-Benz S500 in Top Shape with Quality Engine Cooling Parts

Whether you’re repairing or upgrading your Engine Cooling Part, using high-quality parts is key to keeping your 2000 Mercedes-Benz S500 looking sharp and performing at its best. At Advance Auto Parts we carry a wide selection of dependable options, including Coolant Reservoir Caps, Coolant Reservoirs, and Radiators. Whether you’re replacing a damaged part or enhancing your truck’s style and protection, you’ll find exactly what you need to get the job done right.

Top-Rated Engine Cooling Parts from Trusted Brands

Looking for a reliable Engine Cooling Part? We’ve got you covered with options from brands you know and trust like Carquest Premium. For example, Carquest Premium Engine Cooling Parts start at just $19.99 with an average 4.4 star rating. With over 24 reviews and a solid 5 star average, you can shop with confidence knowing other Mercedes-Benz S500 owners approve.

Competitive Prices and Extensive Inventory

The average price for a 2000 Mercedes-Benz S500 Engine Cooling Part at Advance Auto Parts is around $90.58, with a range that starts at $7.49 and goes up to $288.99. With 17 options in stock from 4 trusted brands, finding the right fit is easy. Popular picks like Coolant Temperature Sensor 1TS1027, Pressurized Coolant Reservoir: Black and White, Plastic, Original Equipment Replacement, and Radiator start at just $27.99 and offer a great balance of form and function.

Explore Related Parts

While you’re upgrading or replacing your Engine Cooling Part, don’t forget to check out other key components like Blower Motor and Related Products and HVAC Electrical Parts. At Advance Auto Parts, we’re here to help you keep your 2000 Mercedes-Benz S500 in peak condition, inside and out.

Essential 2000 Mercedes-Benz S500 Engine Cooling Parts

Dorman – Help – Radiator Drain Cock Screw-In Type With Washer (Part No.61145)

Radiator Drain Cock Screw-In Type With Washer

from

$7.49
This radiator drain petcock is a direct replacement for the original equipment plug that may have deteriorated or corroded. Made of quality materials, this petcock is engineered to strict standards for durable use over time.

Product Features:
  • Direct replacement – this radiator drain petcock matches the fit and function of the original equipment part
  • Durable construction – this part is made of quality materials for a long service life
  • Saves money – offers original equipment quality at a competitive price
  • Quality assured – this petcock has undergone virtual testing to assure proper fit and function
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Carquest Premium – Engine Cooling Fan Motor Relay (Part No.RAA1978)

Engine Cooling Fan Motor Relay

from

$17.99
Relays are electrical switches used to convert a small electrical load into a circuit capable of handling a high amperage load. Computers and small switches are not designed to carry the higher amperage requirement of a circuit that may have an electric motor, solenoid, or high amperage lighting fixture. Within a relay are contacts that are controlled with electromagnetism, when the circuit switch commands the device on or off, magnetism will pull or release the contact arm closing or opening the contacts within the relay that carry the voltage.

Product Features:
  • Product constructed to meet all design and operating characteristics as intended by the vehicle manufacturer.
  • Computer-Aided Design (CAD), laser scanning and 3D printing – utilizing Fused Deposition Modeling (FDM) and Stereolithography (SLA) – in the part design process ensures speed-to-market and a precise fit guaranteed.
  • Where applicable, robust circuit board design increases durability due to heat, shock, and random electro-magnetic pulses (EMP) and power spikes.
  • Tin plated lead frame prevents corrosion and ensures a reliable terminal connection under adverse ambient conditions.
  • 100% thermo-shock and vibration tested to ensure superior performance in extreme conditions.
  • 100% end-of-line tested to ensure accurate signal output providing product reliability, every time.
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Rein – Cap-Expansion Tank (Part No.CPE0026P)

Cap-Expansion Tank

from

$12.99
Rein Automotive OE Quality expansion tank caps are designed to be direct replacements for OE caps. Rein caps are designed to match or exceed the OE materials used and are produced to the highest standards to ensure long service life. Rein Automotive OE quality expansion tank caps keep the coolant system at the proper pressure just like the OE cap.

Product Features:
  • Manufactured to strict engineering standards/specifications in materials and tolerances.
  • Direct fit.
  • Meets or exceeds pressure specifications demanded by the OE manufacturer.
  • Produced by an original equipment supplier.
See More

Carquest Premium – Standard Reservoir Cap: 21 PSI (Part No.10253)

Standard Reservoir Cap: 21 PSI

from

$19.99
Crafted to meet the exact specifications set by Original Equipment Manufacturers (OEM), these products are engineered for effortless installation and removal. Constructed from premium-grade components, incorporating proper relief and vacuum valves, they ensure optimal performance even in the most demanding automotive cooling systems. Rigorously quality-tested, these components provide exceptional, out-of-the-box performance and superior durability to meet or exceed the highest standards of today’s vehicles.

Product Features:
  • Maintains proper cooling system pressure
  • Easy installation and removal
  • 100% tested to ensure proper pressure and longevity
  • Meets all OEM specifications
See More

Rein – Thermostat Insert 80C (Part No.CTI0019)

Thermostat Insert 80C

from

$17.99
Rein Automotive OE quality thermostat inserts install, fit and perform the way the original manufacturer intended. This ensures a smooth and easy installation, just as one would expect to find with OE quality. These inserts are designed to meet or exceed the OE materials used. Rein thermostats are produced with high-quality metals and components to ensure proper durability and service life. The thermostats are temperature calibrated to have a consistent and precise response suiting cooling system needs. Our quality thermostat inserts aim to provide the profession repair technician and vehicle owner peace of mind and trust that is expected from an OE quality component.

Product Features:
  • Matches original equipment design specifications
  • All gaskets or seals necessary for installation are supplied with thermostats
  • Manufactured to strict engineering standards/specifications in materials and tolerances
  • Thermostat set to 80 degrees Celsius to maintain optimal running temperature
See More

Carquest Premium – Integrated Thermostat Housing: With Seal, 192 Degrees (Part No.14569)

Integrated Thermostat Housing: With Seal, 192 Degrees

from

$49.49
Carquest Premium Integrated Housing Thermostats are manufactured with OEM quality materials and safety standards by an OE Supplier. This integrated thermostat housing will meet and exceed the expectations of the OE thermostat to insure the best product for your cooling system. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant as well as the design and function of the housing. Offset design, air relief valve, and OEM style seals included where applicable.

Product Features:
  • High grade stainless steel and copper construction
  • Meets or exceeds OEM standards
  • Consistent and precise response to cooling system needs
  • Original equipment design for worry-free direct fit replacement
  • 100% tested and calibrated
See More

Dorman – Pressurized Coolant Reservoir: Black and Clear, Plastic, Original Equipment Replacement (Part No.603-983)

Pressurized Coolant Reservoir: Black and Clear, Plastic, Original Equipment Replacement

from

$67.99
This replacement engine coolant reservoir is manufactured from quality materials to withstand the stresses of underhood heat and engine vibration. It is engineered and manufactured to match the fit and function of the original part.

Product Features:
  • Direct replacement – this engine coolant reservoir matches the fit and function of the original part
  • Ideal solution – engineered for a seamless installation
  • Durable construction – manufactured from quality materials to withstand underhood heat and vibration
  • Trustworthy design – backed by 100 years of automotive aftermarket experience
See More

URO Parts – Expansion Tank, Coolant level sensor and cap not included (Part No.2205000049)

Expansion Tank, Coolant level sensor and cap not included

from

$28.99
For European vehicles, A.P.A. manufactures the URO Parts brand of quality replacement parts, which meet or exceed OEM specifications. URO Parts components are ideal for both professional and DIY vehicle repair, and are often the exclusive aftermarket alternative to overpriced ¿Genuine¿ components. By reducing deferred maintenance with URO Parts, you will increase the bottom line of your business. With its URO Premium line, A.P.A. offers problem-solving upgraded components that are superior to failure-prone OEM parts in design and/or materials. A.P.A. is so confident in the longevity and reliability of URO Premium products, . URO Parts also specializes in accurate reproduction parts for classic vehicles, including a huge variety of items that are no longer available from the dealer.

Product Features:
  • Guaranteed fitment
  • Precision-molded to OE dimensions to ensure compatibility with original sensors and connections
  • Quality materials resist engine heat and harsh cooling system environment
  • Factory pressure-tested
See More

Dorman – Pressurized Coolant Reservoir: Black and White, Plastic, Original Equipment Replacement (Part No.603-633)

Pressurized Coolant Reservoir: Black and White, Plastic, Original Equipment Replacement

from

$102.99
This replacement engine coolant reservoir is manufactured from quality materials to withstand the stresses of underhood heat and engine vibration. It is engineered and manufactured to match the fit and function of the original part.

Product Features:
  • Direct replacement – this engine coolant reservoir matches the fit and function of the original part
  • Ideal solution – engineered for a seamless installation
  • Durable construction – manufactured from quality materials to withstand underhood heat and vibration
  • Trustworthy design – backed by 100 years of automotive aftermarket experience
See More

Delphi – Engine Coolant Temperature Sensor (Part No.TS10263)

Engine Coolant Temperature Sensor

from

$32.99
Delphi’s history is one of OE heritage and quality. Our global technical requirements include design specifications and validation testing based on over 100 years of OE experience. Our material selections, material thickness, and material types are built from OE specifications to exceed aftermarket expectations. We put in place strict manufacturing processes to ensure quality control in every part we make. Delphi’s pioneering spirit delivers innovative solutions designed to support the aftermarket in servicing the vehicles of today, and tomorrow.

Product Features:
  • Delphi temperature sensors deliver accurate readings and optimal performance
  • Delphi’s 1 piece design and automated production process eliminates internal connectors and failure points
  • Each sensor is electrically insulated to eliminate interference from other components in the vehicle
  • Delphi temperature sensors are impervious to electrical noise and interference
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Carquest Premium – Coolant Temperature Sensor (Part No.WTC1444)

Coolant Temperature Sensor

from

$70.99
Carquest Premium coolant temperature sensors and switches are designed to perform in harsh engine environments and meet or exceed original equipment (O.E.) specifications. Built by manufacturers that meet IATF 16949 certified framework, an internationally recognized proof of quality in the automotive industry, Carquest Premium coolant temperature sensors and switches undergo extensive validation testing to ensure long-lasting performance and reliability. Carquest Premium coolant temperature sensors and switches are part of our Carquest Vehicle Solutions, which is a full line of engine management and electronics products that help control ignition, fuel delivery and emission systems. Carquest Vehicle Solutions are OE-quality parts designed, engineered and tested by world-class manufacturers to ensure a reliable and long-lasting repair.

Product Features:
  • Designed to meet or exceed OE specifications for fit, form and function
  • 100% factory resistance calibrated to ensure precision tolerances, resulting in extremely accurate temperature for optimal performance
  • OE precision matched thermistor ensuring sensors match OE output resistances across all temperature positions
  • O-rings, seals or thread sealant are included if required
  • Weather-tight connectors prevent leaks and corrosion for longer life
  • Extensive design validation testing and 100% end-of-line tested
  • Carquest Vehicle Solutions Technical Support available from ASE certified technicians: 1-866-687-5413
See More

Carquest Premium – Coolant Temperature Sensor 1TS1049 (Part No.WTC1122)

Coolant Temperature Sensor 1TS1049

from

$21.99
Product Features:
  • Designed to meet or exceed OE specifications for fit, form and function
  • 100% factory resistance calibrated to ensure precision tolerances, resulting in extremely accurate temperature for optimal performance
  • OE precision matched thermistor ensuring Carquest sensors match OE output resistances across all temperature positions
  • O-rings, seals or thread sealant are included if required
  • Weather-tight connectors prevent leaks and corrosion for longer life
  • Extensive design validation testing and 100% end-of-line tested
  • Carquest Vehicle Solutions Technical Support available from ASE certified technicians: 1-866-687-5413
See More

Carquest Premium – Radiator (Part No.431426)

Radiator

from

$289.99
Carquest Premium Radiators offer one of the largest product ranges in the aftermarket, covering more than 95% of the popular automotive and light truck applications. Carquest Premium Radiators meet or exceed original equipment specifications, ensuring that products fit and perform just as well or better than the original parts, providing you peace of mind.

Product Features:
  • Our B-type tubes feature central reinforcement to provide greater tolerance to pressure. Stronger tube design means drastically reduced probability of tube failure.
  • Our deep extrusion header provides a stronger tube to header joint which is more resistant to the effects of vibration and thermal tube expansion, virtually eliminating tube to header leaks.
  • Our fin edges are folded for increased stability and heat disbursement properties.
  • Our included “multi-fit” attachments allow one radiator to cover multiple vehicle applications without sacrificing OE fit. This results in wider vehicle coverage with substantially less inventory.
  • Thermal expansion cuts allow for longer life and reduce failure rates by allowing improved core expansion and contraction during normal heat cycles.
  • We design and manufacture all our radiators to meet or even exceed Original Equipment specifications. We take pride in producing the most reliable replacement parts in the market.
  • We use longer header tabs for increased pressure resistance. This reduces the potential for tank to header leaks.
See More

Carquest Premium – Radiator (Part No.432544)

Radiator

from

$288.99
Carquest Premium Radiators offer one of the largest product ranges in the aftermarket, covering more than 95% of the popular automotive and light truck applications. Carquest Premium Radiators meet or exceed original equipment specifications, ensuring that products fit and perform just as well or better than the original parts, providing you peace of mind.

Product Features:
  • Our B-type tubes feature central reinforcement to provide greater tolerance to pressure. Stronger tube design means drastically reduced probability of tube failure.
  • Our deep extrusion header provides a stronger tube to header joint which is more resistant to the effects of vibration and thermal tube expansion, virtually eliminating tube to header leaks.
  • Our fin edges are folded for increased stability and heat disbursement properties.
  • Our included “multi-fit” attachments allow one radiator to cover multiple vehicle applications without sacrificing OE fit. This results in wider vehicle coverage with substantially less inventory.
  • Thermal expansion cuts allow for longer life and reduce failure rates by allowing improved core expansion and contraction during normal heat cycles.
  • We design and manufacture all our radiators to meet or even exceed Original Equipment specifications. We take pride in producing the most reliable replacement parts in the market.
  • We use longer header tabs for increased pressure resistance. This reduces the potential for tank to header leaks.
See More

Dorman – Radiator Fan Control Module (Part No.902-426)

Radiator Fan Control Module

from

$229.99
This engine cooling fan module is designed to match the fit and function of the original module on specified applications. Made of quality materials, it is engineered for reliable performance and durability.

Product Features:
  • Direct replacement – this engine cooling fan module is designed to match the fit and function of the original module on specified applications
  • Ideal solution – this module is a reliable replacement for an original part that has failed due to fatigue or electrical malfunction
  • Durable construction – this part is made from quality materials to ensure reliable performance and a long service life
  • Trustworthy quality – designed in the United States and backed by more than a century of automotive aftermarket excellence
See More

URO Parts – Water Pump Pulley, Steel pulley (Part No.1122020110)

Water Pump Pulley, Steel pulley

from

$42.99
For European vehicles, A.P.A. manufactures the URO Parts brand of quality replacement parts, which meet or exceed OEM specifications. URO Parts components are ideal for both professional and DIY vehicle repair, and are often the exclusive aftermarket alternative to overpriced ¿Genuine¿ components. By reducing deferred maintenance with URO Parts, you will increase the bottom line of your business. With its URO Premium line, A.P.A. offers problem-solving upgraded components that are superior to failure-prone OEM parts in design and/or materials. A.P.A. is so confident in the longevity and reliability of URO Premium products, . URO Parts also specializes in accurate reproduction parts for classic vehicles, including a huge variety of items that are no longer available from the dealer.

Product Features:
  • Guaranteed Fitment
  • High Quality Materials
  • Manufactured to OE water pump pulley dimensions for proper clearances and belt alignment
  • High-strength alloy or composite pulley construction withstands brutal engine heat and vibration
  • Composite pulleys should be replaced at the same time as the water pump
  • Metal pulleys are protected with a durable corrosion-resistant surface coating
See More

Rein – Coolant Drain Plug (Part No.HWB0114)

Coolant Drain Plug

from

$11.99
Product Features:
  • Ensures proper function of engine cooling system.
  • Designed as direct-fit replacement to ensure trouble-free proper installations.
  • Manufactured to strict engineering standards and specifications in materials and tolerances.
See More

Carquest Premium – Engine Water Pump: New, Gasket/Seals Included (Part No.T5101)

Engine Water Pump: New, Gasket/Seals Included

from

$192.99
This premium water pump uses new high-quality components and is designed to meet or exceed OE specifications. This pump is 100% tested to ensure quality. Bearings, gaskets, seals, impeller, hub and housing are all designed for long-lasting service life. All necessary gaskets and seals are included.

Product Features:
  • 100% tested for reliable performance
  • Durable housing features precisely machined mounting surface for proper sealing and fitment
  • Equipped with weep chamber or similar feature to help prevent unnecessary replacement
  • Included heavy-duty unitized bearings, pressed-on hubs and optimal impeller clearance for a long-lasting water pump
  • All gaskets or seals necessary for water pump are included
  • This pump is driven by the accessory belt and we recommend replacement if nearing service recommendation
  • This pump is driven by the timing chain; see vehicle manufacturer recommendation for replacement of timing components
  • This pump is driven by the timing belt; see vehicle manufacturer recommendation for replacement of timing components
  • Additional Notes: Includes gasket
See More

Carquest Premium – Engine Water Pump: New, Gasket/Seals Included (Part No.T5100)

Engine Water Pump: New, Gasket/Seals Included

from

$189.99
This premium water pump uses new high-quality components and is designed to meet or exceed OE specifications. This pump is 100% tested to ensure quality. Bearings, gaskets, seals, impeller, hub and housing are all designed for long-lasting service life. All necessary gaskets and seals are included.

Product Features:
  • Built to meet or exceed OE fit, form and function
  • All components necessary for installation are supplied with pump
  • 100% tested for reliable performance
  • Follow all enclosed instructions to maximize pump life and validate warranty
  • Additional Notes: Includes gasket
See More

Rein – Water Pump- Metal Impeller (Part No.WPR0017)

Water Pump- Metal Impeller

from

$149.99
Rein Automotive OE quality water pumps are designed to be direct replacements for OE water pumps and water pump assembles. Rein water pumps are made to original casting specifications to ensure proper fitments for easy installation, proper water flow and maximum cooling. Pumps include the necessary OE style gaskets and/or o-rings to replace the old worn out parts. Seals are made from a high quality silicate carbide compound. Bearings of OE design and materials are also used to meet or exceed OEM standards and ensure long service life. Our quality water pumps aim to provide the professional repair technician and vehicle owner the peace of mind and trust that is expected from an OE quality component, and are backed by 4 years and 50,000 mile Limited Warranty. Please read and follow all enclosed instructions to maximize pump life and validate Limited Warranty.

Product Features:
  • Pump is produced with silicon carbide seals providing improved durability and service life
  • Pump uses OE designed bearings by ensuring to extend pumps service life
  • Pumps backed by 4 years and 50,000 mile Limited Warranty
  • Read and follow all enclosed instructions to maximize pump life and to qualify for extended Limited Warranty
See More

Rein – Water Pump- Metal Impeller (Part No.WPR0018)

Water Pump- Metal Impeller

from

$126.99
Rein Automotive OE quality water pumps are designed to be direct replacements for OE water pumps and water pump assembles. Rein water pumps are made to original casting specifications to ensure proper fitments for easy installation, proper water flow and maximum cooling. Pumps include the necessary OE style gaskets and/or o-rings to replace the old worn out parts. Seals are made from a high quality silicate carbide compound. Bearings of OE design and materials are also used to meet or exceed OEM standards and ensure long service life. Our quality water pumps aim to provide the professional repair technician and vehicle owner the peace of mind and trust that is expected from an OE quality component, and are backed by 4 years and 50,000 mile Limited Warranty. Please read and follow all enclosed instructions to maximize pump life and validate Limited Warranty.

Product Features:
  • Pump is produced with silicon carbide seals providing improved durability and service life
  • Pump uses OE designed bearings by ensuring to extend pumps service life
  • Pumps backed by 4 years and 50,000 mile Limited Warranty
  • Read and follow all enclosed instructions to maximize pump life and to qualify for extended Limited Warranty
See More

Most Popular Coolant Reservoir Caps for 2000 Mercedes-Benz S500s

Enhance your 2000 Mercedes-Benz S500 with one of the 2 Coolant Reservoir Caps we have in stock, starting at just $19.99.

Carquest Premium – Standard Reservoir Cap: 21 PSI (Part No.10253)

Standard Reservoir Cap: 21 PSI

from

$19.99
Crafted to meet the exact specifications set by Original Equipment Manufacturers (OEM), these products are engineered for effortless installation and removal. Constructed from premium-grade components, incorporating proper relief and vacuum valves, they ensure optimal performance even in the most demanding automotive cooling systems. Rigorously quality-tested, these components provide exceptional, out-of-the-box performance and superior durability to meet or exceed the highest standards of today’s vehicles.

Product Features:
  • Maintains proper cooling system pressure
  • Easy installation and removal
  • 100% tested to ensure proper pressure and longevity
  • Meets all OEM specifications
See More

Rein – Cap-Expansion Tank (Part No.CPE0029P)

Cap-Expansion Tank

from

$32.99
Rein Automotive OE Quality expansion tank caps are designed to be direct replacements for OE caps. Rein caps are designed to match or exceed the OE materials used and are produced to the highest standards to ensure long service life. Rein Automotive OE quality expansion tank caps keep the coolant system at the proper pressure just like the OE cap.

Product Features:
  • Manufactured to strict engineering standards/specifications in materials and tolerances.
  • Direct fit.
  • Meets or exceeds pressure specifications demanded by the OE manufacturer.
  • Produced by an original equipment supplier.
See More

Best-Selling 2000 Mercedes-Benz S500 Coolant Reservoirs

Upgrade your S500 with one of our 2 best-selling Coolant Reservoirs.

Dorman – Pressurized Coolant Reservoir: Black and White, Plastic, Original Equipment Replacement (Part No.603-633)

Pressurized Coolant Reservoir: Black and White, Plastic, Original Equipment Replacement

from

$102.99
This replacement engine coolant reservoir is manufactured from quality materials to withstand the stresses of underhood heat and engine vibration. It is engineered and manufactured to match the fit and function of the original part.

Product Features:
  • Direct replacement – this engine coolant reservoir matches the fit and function of the original part
  • Ideal solution – engineered for a seamless installation
  • Durable construction – manufactured from quality materials to withstand underhood heat and vibration
  • Trustworthy design – backed by 100 years of automotive aftermarket experience
See More

URO Parts – Expansion Tank, Coolant level sensor and cap not included (Part No.2205000049)

Expansion Tank, Coolant level sensor and cap not included

from

$28.99
For European vehicles, A.P.A. manufactures the URO Parts brand of quality replacement parts, which meet or exceed OEM specifications. URO Parts components are ideal for both professional and DIY vehicle repair, and are often the exclusive aftermarket alternative to overpriced ¿Genuine¿ components. By reducing deferred maintenance with URO Parts, you will increase the bottom line of your business. With its URO Premium line, A.P.A. offers problem-solving upgraded components that are superior to failure-prone OEM parts in design and/or materials. A.P.A. is so confident in the longevity and reliability of URO Premium products, . URO Parts also specializes in accurate reproduction parts for classic vehicles, including a huge variety of items that are no longer available from the dealer.

Product Features:
  • Guaranteed fitment
  • Precision-molded to OE dimensions to ensure compatibility with original sensors and connections
  • Quality materials resist engine heat and harsh cooling system environment
  • Factory pressure-tested
See More

Top-Quality Radiators for 2000 Mercedes-Benz S500s

Choose a high-quality OEM or aftermarket Radiator for Mercedes-Benz S500s and enjoy top-notch performance from $288.99.

Carquest Premium – Radiator (Part No.432544)

Radiator

from

$288.99
Carquest Premium Radiators offer one of the largest product ranges in the aftermarket, covering more than 95% of the popular automotive and light truck applications. Carquest Premium Radiators meet or exceed original equipment specifications, ensuring that products fit and perform just as well or better than the original parts, providing you peace of mind.

Product Features:
  • Our B-type tubes feature central reinforcement to provide greater tolerance to pressure. Stronger tube design means drastically reduced probability of tube failure.
  • Our deep extrusion header provides a stronger tube to header joint which is more resistant to the effects of vibration and thermal tube expansion, virtually eliminating tube to header leaks.
  • Our fin edges are folded for increased stability and heat disbursement properties.
  • Our included “multi-fit” attachments allow one radiator to cover multiple vehicle applications without sacrificing OE fit. This results in wider vehicle coverage with substantially less inventory.
  • Thermal expansion cuts allow for longer life and reduce failure rates by allowing improved core expansion and contraction during normal heat cycles.
  • We design and manufacture all our radiators to meet or even exceed Original Equipment specifications. We take pride in producing the most reliable replacement parts in the market.
  • We use longer header tabs for increased pressure resistance. This reduces the potential for tank to header leaks.
See More

Top Picks for 2000 Mercedes-Benz S500 Water Pumps

Invest in one of our 4 durable Water Pumps for your 2000 Mercedes-Benz, knowing you’re getting trusted brands and expert craftsmanship.

Carquest Premium – Engine Water Pump: New, Gasket/Seals Included (Part No.T5101)

Engine Water Pump: New, Gasket/Seals Included

from

$192.99
This premium water pump uses new high-quality components and is designed to meet or exceed OE specifications. This pump is 100% tested to ensure quality. Bearings, gaskets, seals, impeller, hub and housing are all designed for long-lasting service life. All necessary gaskets and seals are included.

Product Features:
  • 100% tested for reliable performance
  • Durable housing features precisely machined mounting surface for proper sealing and fitment
  • Equipped with weep chamber or similar feature to help prevent unnecessary replacement
  • Included heavy-duty unitized bearings, pressed-on hubs and optimal impeller clearance for a long-lasting water pump
  • All gaskets or seals necessary for water pump are included
  • This pump is driven by the accessory belt and we recommend replacement if nearing service recommendation
  • This pump is driven by the timing chain; see vehicle manufacturer recommendation for replacement of timing components
  • This pump is driven by the timing belt; see vehicle manufacturer recommendation for replacement of timing components
  • Additional Notes: Includes gasket
See More

Carquest Premium – Engine Water Pump: New, Gasket/Seals Included (Part No.T5100)

Engine Water Pump: New, Gasket/Seals Included

from

$189.99
This premium water pump uses new high-quality components and is designed to meet or exceed OE specifications. This pump is 100% tested to ensure quality. Bearings, gaskets, seals, impeller, hub and housing are all designed for long-lasting service life. All necessary gaskets and seals are included.

Product Features:
  • Built to meet or exceed OE fit, form and function
  • All components necessary for installation are supplied with pump
  • 100% tested for reliable performance
  • Follow all enclosed instructions to maximize pump life and validate warranty
  • Additional Notes: Includes gasket
See More

Rein – Water Pump- Metal Impeller (Part No.WPR0018)

Water Pump- Metal Impeller

from

$126.99
Rein Automotive OE quality water pumps are designed to be direct replacements for OE water pumps and water pump assembles. Rein water pumps are made to original casting specifications to ensure proper fitments for easy installation, proper water flow and maximum cooling. Pumps include the necessary OE style gaskets and/or o-rings to replace the old worn out parts. Seals are made from a high quality silicate carbide compound. Bearings of OE design and materials are also used to meet or exceed OEM standards and ensure long service life. Our quality water pumps aim to provide the professional repair technician and vehicle owner the peace of mind and trust that is expected from an OE quality component, and are backed by 4 years and 50,000 mile Limited Warranty. Please read and follow all enclosed instructions to maximize pump life and validate Limited Warranty.

Product Features:
  • Pump is produced with silicon carbide seals providing improved durability and service life
  • Pump uses OE designed bearings by ensuring to extend pumps service life
  • Pumps backed by 4 years and 50,000 mile Limited Warranty
  • Read and follow all enclosed instructions to maximize pump life and to qualify for extended Limited Warranty
See More

Rein – Water Pump- Metal Impeller (Part No.WPR0017)

Water Pump- Metal Impeller

from

$149.99
Rein Automotive OE quality water pumps are designed to be direct replacements for OE water pumps and water pump assembles. Rein water pumps are made to original casting specifications to ensure proper fitments for easy installation, proper water flow and maximum cooling. Pumps include the necessary OE style gaskets and/or o-rings to replace the old worn out parts. Seals are made from a high quality silicate carbide compound. Bearings of OE design and materials are also used to meet or exceed OEM standards and ensure long service life. Our quality water pumps aim to provide the professional repair technician and vehicle owner the peace of mind and trust that is expected from an OE quality component, and are backed by 4 years and 50,000 mile Limited Warranty. Please read and follow all enclosed instructions to maximize pump life and validate Limited Warranty.

Product Features:
  • Pump is produced with silicon carbide seals providing improved durability and service life
  • Pump uses OE designed bearings by ensuring to extend pumps service life
  • Pumps backed by 4 years and 50,000 mile Limited Warranty
  • Read and follow all enclosed instructions to maximize pump life and to qualify for extended Limited Warranty
See More

Our Top-Rated Thermostats for 2000 Mercedes-Benz S500s

Make a smart move for your 2000 Mercedes-Benz S500 with our Thermostat for $49.49.

Carquest Premium – Integrated Thermostat Housing: With Seal, 192 Degrees (Part No.14569)

Integrated Thermostat Housing: With Seal, 192 Degrees

from

$49.49
Carquest Premium Integrated Housing Thermostats are manufactured with OEM quality materials and safety standards by an OE Supplier. This integrated thermostat housing will meet and exceed the expectations of the OE thermostat to insure the best product for your cooling system. Stands up to even the most demanding automotive cooling systems. Manufactured with OEM specifications and processes. Copper case and wax compound assures rapid response to temperature changes in the coolant as well as the design and function of the housing. Offset design, air relief valve, and OEM style seals included where applicable.

Product Features:
  • High grade stainless steel and copper construction
  • Meets or exceeds OEM standards
  • Consistent and precise response to cooling system needs
  • Original equipment design for worry-free direct fit replacement
  • 100% tested and calibrated
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Top-Rated Engine Cooling Part Brands For Your 2000 Mercedes-Benz S500

When it comes to finding the perfect Engine Cooling Part for your 2000 Mercedes-Benz S500, Advance Auto Parts has you covered with a wide selection of high-quality OEM and aftermarket options from 4 trusted brands. We carry the most popular Engine Cooling Part brands including Carquest Premium, and more, all known for their exceptional customer ratings (average brand rating of 4.4 stars) and competitive prices, as low as $19.99. Purchasing a Engine Cooling Part from us here at Advance Auto Parts is a smart move for both you and your 2000 Mercedes-Benz S500, providing peace of mind with parts that meet or exceed OEM standards.

Popular Carquest Premium 2000 Mercedes-Benz S500 Engine Cooling Parts

If you’re looking for a top-quality Engine Cooling Part for your 2000 Mercedes-Benz S500, Advance Auto Parts has exactly what you need with our selection of Carquest Premium Engine Cooling Parts. We have 3 Carquest Premium Engine Cooling Parts in stock for this fitment, all known for their durability and precision fit. With prices starting at just $19.99 and an average cost of $87.49, you’ll find the perfect Engine Cooling Part for your needs and budget. Carquest Premium Engine Cooling Parts for the 2000 Mercedes-Benz S500 come highly rated, with over 7 customer reviews and an impressive average rating of 4.4 stars. Choosing a Carquest Premium Engine Cooling Part from Advance Auto Parts is a smart move to ensure quality and value for your vehicle.
Integrated Thermostat Housing: With Seal, 192 Degrees
from $49.49
(5)
Integrated Thermostat Housing: With Seal, 192 Degrees
“Was boxed as house brand, but actually is a wahler thermostat, a brand I completely trust for my Mercedes. Temp gauge was reading low, and heat was ”
Standard Reservoir Cap: 21 PSI
from $19.99
(1)
Standard Reservoir Cap: 21 PSI
“Works well, looks identical to OEM!”
Engine Water Pump: New, Gasket/Seals Included
from $192.99
(1)
Engine Water Pump: New, Gasket/Seals Included
“Perfect fit”

FAQs for 2000 Mercedes-Benz S500 Engine Cooling Parts

What are the best-selling Engine Cooling Parts for 2000 Mercedes-Benz S500s?

Out of 17 Engine Cooling Parts that fit 2000 Mercedes-Benz S500s, the following parts are the top sellers:

What’s the price range for 2000 Mercedes-Benz S500 Engine Cooling Parts?

The prices of Engine Cooling Parts for the 2000 Mercedes-Benz S500 range from $7.49 up to $288.99 for the most premium parts.

What is the average price of an Engine Cooling Part for a 2000 Mercedes-Benz S500?

The average price for Engine Cooling Parts for the 2000 Mercedes-Benz S500 is $90.58. Keep in mind the variety of part types within our Engine Cooling Part category, where you are likely to find a wide range of prices across a variety of parts and components.

Does Advance Auto Parts sell Engine Cooling Parts for other Mercedes-Benz S500 model years?

Yes, we carry Engine Cooling Parts for 16 model years of Mercedes-Benz S500s between 1994 and 2025. The following model years are the most popular for Engine Cooling Part purchases: 2023, 2022, 2021, 2006, 2005, 2004, 2003, 2002, and 2001.

What are the cheapest Engine Cooling Parts for my 2000 Mercedes-Benz S500?

The cheapest 2000 Mercedes-Benz S500 Engine Cooling Parts we carry are:

Does Advance Auto Parts sell Engine Cooling Parts for any other 2000 Mercedes-Benz models?

Yes. We stock Engine Cooling Parts for 14 other popular 2000 Mercedes-Benz models. Some of the most popular are 2000 E320 Engine Cooling Parts, 2000 SL600 Engine Cooling Parts, 2000 SL500 Engine Cooling Parts, 2000 C230 Engine Cooling Parts, and 2000 ML320 Engine Cooling Parts.

What are the top-rated Engine Cooling Parts that fit the 2000 Mercedes-Benz S500?

The one 2000 Mercedes-Benz S500 Engine Cooling Part we have in stock is the Radiator Drain Cock Screw-In Type With Washer. It costs $7.49.

What types of Engine Cooling Parts do you sell for my 2000 Mercedes-Benz S500?

As of 3/1/26, these are some of the most in-demand types of Engine Cooling Parts for a 2000 Mercedes-Benz S500:

Can I get help with 2000 Mercedes-Benz S500 Engine Cooling Part orders?

Contact our customer support team by chat or phone, through the help desk page, where you can find instant answers about Mercedes-Benz Engine Cooling Parts and more.

What is your return policy for Mercedes-Benz S500 Engine Cooling Parts?

Advance Auto Parts keeps returns simple. For new Mercedes-Benz S500 Engine Cooling Parts and accessories, your online orders can be returned, in their original condition, within 45 days. For requirements, see the returns page.